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hippocampal sparing ,cranial irradiation

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https://www.readbyqxmd.com/read/28581401/prospective-study-of-hippocampal-sparing-prophylactic-cranial-irradiation-in-limited-stage-small-cell-lung-cancer
#1
Kristin J Redmond, Russell K Hales, Heather Anderson-Keightly, Xian C Zhou, Megan Kummerlowe, Haris I Sair, Mario Duhon, Lawrence Kleinberg, Gary L Rosner, Tracy Vannorsdall
PURPOSE: To prospectively evaluate cognitive function and intracranial failure patterns after hippocampal-sparing prophylactic cranial irradiation (PCI) for limited-stage small cell lung cancer (SCLC). METHODS AND MATERIALS: Adults with limited-stage SCLC, achieving a complete response to chemoradiotherapy and no brain metastases, were eligible. Patients received PCI 25 Gy/10 fractions, with a mean hippocampal dose limited to <8 Gy and ≥90% of the brain receiving 90% of the prescription...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28510808/development-of-a-contouring-guide-in-three-different-head-set-ups-for-hippocampal-sparing-radiotherapy-a-practical-approach
#2
Saide Di Biase, Marianna Trignani, Luciana Caravatta, Paul Ioan Voicu, Clelia Di Carlo, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Valentina Panara, Domenico Genovesi
BACKGROUNDS: Irradiation of the hippocampus plays a role in neurocognitive toxicity. Its delineation is complex and in practice different head position can vary hippocampus morphology on axial images; so atlas in a single standard position can result ineffective to describe different hippocampal morphologies in different head set-up. The purpose of our study was to develop a guide based on magnetic resonance imaging for hippocampus delineation in three different head set-ups. MATERIALS AND METHODS: Three patients were selected to elaborate our guide...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28340924/hippocampal-sparing-whole-brain-radiotherapy-for-lung-cancer
#3
REVIEW
Ren Zhao, Wei Kong, Jun Shang, Hong Zhe, Yan-Yang Wang
Brain metastases occur in 20% to 40% of lung cancer patients. Whole-brain radiotherapy (WBRT) has long been considered the treatment of choice for many patients with lung cancer, because of its wide availability, ease of delivery, and effectiveness in prolonging survival. However, WBRT is also associated with several side effects, such as decline in memory and other cognitive functions. There exists significant preclinical and clinical evidence that radiation-induced injury to the hippocampus correlates with neurocognitive decline of patients who receive WBRT...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28182655/regional-analysis-of-volumes-and-reproducibilities-of-automatic-and-manual-hippocampal-segmentations
#4
Fabian Bartel, Hugo Vrenken, Fetsje Bijma, Frederik Barkhof, Marcel van Herk, Jan C de Munck
PURPOSE: Precise and reproducible hippocampus outlining is important to quantify hippocampal atrophy caused by neurodegenerative diseases and to spare the hippocampus in whole brain radiation therapy when performing prophylactic cranial irradiation or treating brain metastases. This study aimed to quantify systematic differences between methods by comparing regional volume and outline reproducibility of manual, FSL-FIRST and FreeSurfer hippocampus segmentations. MATERIALS AND METHODS: This study used a dataset from ADNI (Alzheimer's Disease Neuroimaging Initiative), including 20 healthy controls, 40 patients with mild cognitive impairment (MCI), and 20 patients with Alzheimer's disease (AD)...
2017: PloS One
https://www.readbyqxmd.com/read/27675962/a-prospective-study-of-hippocampal-sparing-prophylactic-cranial-irradiation-pci-in-limited-stage-small-cell-lung-cancer-sclc
#5
K J Redmond, R K Hales, X C Zhou, M Kummerlowe, H Sair, M Duhon, L R Kleinberg, G Rosner, T Vannorsdall
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26674923/incidence-and-relapse-risk-of-intracranial-metastases-within-the-perihippocampal-region-in-314-patients-with-breast-cancer
#6
Bing Sun, Zhou Huang, Shikai Wu, Ge Shen, Lei Cha, Xiangying Meng, Lijuan Ding, Junliang Wang, Santai Song
PURPOSE: The safe prerequisite of hippocampal-sparing whole brain radiotherapy (HS-WBRT) for patients with breast cancer is unclear. This study investigated the risk and relapse of perihippocampal (PH) metastases in breast cancer. METHODS: Consecutive breast cancer patients with brain metastasis (BM) were reviewed. Metastases and hippocampi were contoured in cranial magnetic resonance imaging (MRI). The closest distance from metastasis to hippocampus was calculated...
January 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26654128/hippocampal-dosimetry-correlates-with-the-change-in-neurocognitive-function-after-hippocampal-sparing-during-whole-brain-radiotherapy-a-prospective-study
#7
Ping-Fang Tsai, Chi-Cheng Yang, Chi-Cheng Chuang, Ting-Yi Huang, Yi-Ming Wu, Ping-Ching Pai, Chen-Kan Tseng, Tung-Ho Wu, Yi-Liang Shen, Shinn-Yn Lin
BACKGROUND: Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the preservation of NCFs. Our study aims to investigate the hippocampal dosimetry and to demonstrate the correlation between hippocampal dosimetry and neurocognitive outcomes in patients receiving hippocampal sparing during WBRT (HS-WBRT)...
December 10, 2015: Radiation Oncology
https://www.readbyqxmd.com/read/26128112/su-e-t-449-hippocampal-sparing-radiotherapy-using-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#8
S Moon, D Kim, W Chung, M Yoon
PURPOSE: The hippocampus sparing during the cranial irradiation has become interesting because it may mitigate radiation-induced neurocognitive toxicity. Herein we report our preliminary study for sparing the hippocampus with and without tilling condition for patient with brain metastases. METHODS: Ten patients previously treated with whole brain were reviewed. Five patients tilted the head to around 30 degrees and others were treated without tilting. Treatment plans of linear accelerator (Linac)-based volumetric modulated arc therapy (VMAT) and intensity modulated radiotherapy (IMRT) were generated for prescription dose of 30 Gy in 15 fractions...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26119727/neurocognitive-effects-following-cranial-irradiation-for-brain-metastases
#9
REVIEW
M B Pinkham, P Sanghera, G K Wall, B D Dawson, G A Whitfield
About 90% of patients with brain metastases have impaired neurocognitive function at diagnosis and up to two-thirds will show further declines within 2-6 months of whole brain radiotherapy. Distinguishing treatment effects from progressive disease can be challenging because the prognosis remains poor in many patients. Omitting whole brain radiotherapy after local therapy in good prognosis patients improves verbal memory at 4 months, but the effect of higher intracranial recurrence and salvage therapy rates on neurocognitive function beyond this time point is unknown...
November 2015: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/25994802/evaluating-the-impact-of-hippocampal-sparing-during-whole-brain-radiotherapy-on-neurocognitive-functions-a-preliminary-report-of-a-prospective-phase-ii-study
#10
Shinn-Yn Lin, Chi-Cheng Yang, Yi-Ming Wu, Chen-Kan Tseng, Kuo-Chen Wei, Yi-Chuan Chu, Hsiang-Yao Hsieh, Tung-Ho Wu, Ping-Ching Pai, Peng-Wei Hsu, Chi-Cheng Chuang
BACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study...
September 2015: Biomedical Journal
https://www.readbyqxmd.com/read/25752392/risk-of-hippocampal-metastases-in-small-cell-lung-cancer-patients-at-presentation-and-after-cranial-irradiation-a-safety-profile-study-for-hippocampal-sparing-during-prophylactic-or-therapeutic-cranial-irradiation
#11
Vijayananda Kundapur, Tasha Ellchuk, Shahid Ahmed, Vinai Gondi
PURPOSE: Neurocognitive impairment (NI) in patients with small cell lung cancer (SCLC) after whole brain radiation treatment (WBRT) is a significant cause of morbidity. Hippocampal avoidance (HA) during WBRT may mitigate or prevent NI in such patients. However, this has not been tested in SCLC patients. The estimated risk of metastases in the HA region (HM) in patients with SCLC at diagnosis or after WBRT is unknown. Our study aimed to determine the risk of HM in patients with SCLC and to assess correlated clinical factors...
March 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25687977/the-influences-of-whole-brain-radiotherapy-on-social-cognition-and-association-with-hippocampal-and-frontal-dosimetry
#12
Erhan Yuksek, Seda Eroz, Ahmet Yassa, Dilara Akturk, Fagan Zakirov, Funda Engin Akcam, Murat Emul
The influence of brain radiotherapy on neurocognition is a major concern. Social cognition is a mental process in the meaning of social interaction and the recognition of facial emotion is a domain of social cognition. Thus, we aimed to investigate the early effect of whole brain radiotherapy on facial emotion recognition ability. Thirteen patients with various brain tumors in the study. Beck depression and anxiety inventory and the facial emotion recognition test by using a set of photographs were performed at the beginning and post radiotherapy...
December 2015: Psychiatric Quarterly
https://www.readbyqxmd.com/read/24935286/why-and-how-to-spare-the-hippocampus-during-brain-radiotherapy-the-developing-role-of-hippocampal-avoidance-in-cranial-radiotherapy
#13
REVIEW
Tomas Kazda, Radim Jancalek, Petr Pospisil, Ondrej Sevela, Tomas Prochazka, Miroslav Vrzal, Petr Burkon, Marek Slavik, Ludmila Hynkova, Pavel Slampa, Nadia N Laack
The goal of this review is to summarize the rationale for and feasibility of hippocampal sparing techniques during brain irradiation. Radiotherapy is the most effective non-surgical treatment of brain tumors and with the improvement in overall survival for these patients over the last few decades, there is an effort to minimize potential adverse effects leading to possible worsening in quality of life, especially worsening of neurocognitive function. The hippocampus and associated limbic system have long been known to be important in memory formation and pre-clinical models show loss of hippocampal stem cells with radiation as well as changes in architecture and function of mature neurons...
2014: Radiation Oncology
https://www.readbyqxmd.com/read/24446074/persistent-changes-in-neuronal-structure-and-synaptic-plasticity-caused-by-proton-irradiation
#14
Vipan K Parihar, Junaid Pasha, Katherine K Tran, Brianna M Craver, Munjal M Acharya, Charles L Limoli
Cranial radiotherapy is used routinely to control the growth of primary and secondary brain tumors, but often results in serious and debilitating cognitive dysfunction. In part due to the beneficial dose depth distributions that may spare normal tissue damage, the use of protons to treat CNS and other tumor types is rapidly gaining popularity. Astronauts exposed to lower doses of protons in the space radiation environment are also at risk for developing adverse CNS complications. To explore the consequences of whole body proton irradiation, mice were subjected to 0...
March 2015: Brain Structure & Function
https://www.readbyqxmd.com/read/24112545/whole-brain-helical-tomotherapy-with-integrated-boost-for-brain-metastases-in-patients-with-malignant-melanoma-a-randomized-trial
#15
RANDOMIZED CONTROLLED TRIAL
Henrik Hauswald, Gregor Habl, David Krug, Denise Kehle, Stephanie E Combs, Justo Lorenzo Bermejo, Jürgen Debus, Florian Sterzing
BACKGROUND: Patients with malignant melanoma may develop brain metastases during the course of the disease, requiring radiotherapeutic treatment. In patients with 1-3 brain metastases, radiosurgery has been established as a treatment option besides surgery. For patients with 4 or more brain metastases, whole brain radiotherapy is considered the standard treatment. In certain patients with brain metastases, radiation treatment using whole brain helical Tomotherapy with integrated boost and hippocampal-sparing may improve prognosis of these patients...
2013: Radiation Oncology
https://www.readbyqxmd.com/read/24100152/estimation-of-intracranial-failure-risk-following-hippocampal-sparing-whole-brain-radiotherapy
#16
Saskia Harth, Yasser Abo-Madyan, Lei Zheng, Kerstin Siebenlist, Carsten Herskind, Frederik Wenz, Frank A Giordano
PURPOSE: To estimate the risk of undertreatment in hippocampal-sparing whole brain radiotherapy (HS-WBRT). METHODS: Eight hundred and fifty six metastases were contoured together with the hippocampi in cranial MRIs of 100 patients. For each metastasis, the distance to the closest hippocampus was calculated. Treatment plans for 10 patients were calculated and linear dose profiles were established. For SCLC and NSCLC, dose-response curves were created based on data from studies on prophylactic cranial irradiation, allowing estimating the risk for intracranial failure...
October 2013: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/24048959/treatment-of-brain-metastases-in-lung-cancer-strategies-to-avoid-reduce-late-complications-of-whole-brain-radiation-therapy
#17
REVIEW
Mark G Shaw, David L Ball
Brain metastases occur in 20-40 % of lung cancer patients. The use of whole brain radiation therapy (WBRT) has been shown to ameliorate many neurological symptoms, facilitate corticosteroid reduction, enhance quality of life (QOL), and prolong survival. The acute and early delayed side effects of WBRT are generally mild and inconsequential, whereas late complications often are progressive, irreversible, and may have a profound effect on neurocognitive function and QOL. Nevertheless, WBRT remains the cornerstone for treatment of multiple brain metastases due to its efficacy and the paucity of other treatment options...
December 2013: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/24011597/-the-role-of-whole-brain-radiotherapy-with-hippocampal-sparing
#18
G Truc, É Martin, C Mirjolet, J Chamois, A Petitfils, G Créhange
Hippocampi plays a fundamental role in immediate or long-term memory and the spatial learning. This structure is rarely involved by metastasis and their irradiation is at the origin of some impairment of the neurocognitive function. Sparing hippocampi during whole brain radiation therapy becomes possible with volumetric modulated arc therapy (VMAT) or with helical tomotherapy. The delineation of the structures should be performed after coregistration of gadolinium-enhanced T1-weighted MR-images with the planning...
October 2013: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/23322748/association-between-radiation-dose-to-neuronal-progenitor-cell-niches-and-temporal-lobes-and-performance-on-neuropsychological-testing-in-children-a-prospective-study
#19
Kristin J Redmond, E Mark Mahone, Stephanie Terezakis, Omar Ishaq, Eric Ford, Todd McNutt, Lawrence Kleinberg, Kenneth J Cohen, Moody Wharam, Alena Horska
BACKGROUND: Neurocognitive toxicity from radiation therapy (RT) for brain tumors may be related to damage to neural progenitor cells that reside in the subventricular zone and hippocampus. This prospective study examines the relationship between RT dose to neural progenitor cell niches, temporal lobes, and cerebrum and neurocognitive dysfunction following cranial irradiation. METHODS: Standardized assessments of motor speed/dexterity, verbal memory, visual perception, vocabulary, and visuospatial working memory were conducted in 19 pediatric patients receiving cranial RT and 55 controls at baseline and 6, 15, and 27 months following completion of RT...
March 2013: Neuro-oncology
https://www.readbyqxmd.com/read/23312272/hippocampal-dosimetry-predicts-neurocognitive-function-impairment-after-fractionated-stereotactic-radiotherapy-for-benign-or-low-grade-adult-brain-tumors
#20
Vinai Gondi, Bruce P Hermann, Minesh P Mehta, Wolfgang A Tomé
PURPOSE: To prospectively evaluate the association between hippocampal dose and long-term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors treated with fractionated stereotactic radiotherapy (FSRT). METHODS AND MATERIALS: Adult patients with benign or low-grade adult brain tumors were treated with FSRT per institutional practice. No attempt was made to spare the hippocampus. NCF testing was conducted at baseline and 18 months follow-up, on a prospective clinical trial...
February 1, 2013: International Journal of Radiation Oncology, Biology, Physics
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