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https://www.readbyqxmd.com/read/29458206/mucoadhesive-self-emulsifying-delivery-systems-for-ocular-administration-of-econazole
#1
Ibrahim A Elbahwy, Noemi Lupo, Hany M Ibrahim, Hatem R Ismael, Alaa A Kasem, Cagri Caliskan, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Development of mucoadhesive self-emulsifying drug delivery systems (SEDDS) providing a prolonged ocular residence time for poorly soluble active pharmaceutical ingredient. METHODS: L-Cysteine was covalently linked to 6-mercaptonicotinamide. The obtained ligand, Cysteine-6- mercaptonicotinamide (Cys-6-MNA) was attached to Eudragit® L100-55 via a carbodiimide mediated amide bond formation. The resulting entirely S-protected thiolated Eudragit® L100-55 was characterized regarding the degree of modification as well as stability toward oxidation in the presence of strong oxidizing agent (H2 O2 )...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458037/distinguishing-keratoconic-eyes-and-healthy-eyes-using-ultrahigh-resolution-uhr-oct-based-corneal-epithelium-thickness-mapping
#2
Niklas Pircher, Florian Schwarzhans, Stephan Holzer, Jan Lammer, Doreen Schmidl, Ahmed M Bata, Renè M Werkmeister, Gerald Seidel, Gerhard Garhöfer, Andreas Gschließer, Leopold Schmetterer, Gerald Schmidinger
PURPOSE: Discovering new predictive parameters in the diagnostics of Keratoconus (KC) has high priority. Aim of this trial was to find differences in epithelial thickness (ET) maps of eyes with KC and healthy eyes. DESIGN: Institutional cross-sectional study. METHODS: In this study 40 keratoconic eyes and 76 healthy eyes were scanned using a custom-built ultrahigh resolution OCT. Automated segmentation ET-maps with 17 subsectors were calculated (central, temporal inferior, temporal superior, nasal inferior and nasal superior area)...
February 16, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29456812/preparation-and-evaluation-of-pcl-peg-pcl-micelles-as-potential-nanocarriers-for-ocular-delivery-of-dexamethasone
#3
Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Roya Salehi, Mitra Jelvehgari
Objectives: Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble drugs. Materials and Methods: The PCL-PEG-PCL copolymers were synthesized via the ring opening polymerization of ε-caprolactone in the presence of PEG...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456673/full-thickness-conjunctival-flap-covering-surgery-combined-with-amniotic-membrane-transplantation-for-severe-fungal-keratitis
#4
Jing Zhong, Bowen Wang, Saiqun Li, Yuqing Deng, Haixiang Huang, Ling Chen, Jin Yuan
Fungal keratitis is a severe and common ocular infectious disease. The present study evaluated the efficiency of full-thickness conjunctival flap covering surgery with amniotic membrane transplantation (FCCS + AMT) as a transitional surgery for severe fungal keratitis. A total of 17 patients with severe fungal keratitis without corneal perforation underwent FCCS + AMT between January 2010 and December 2015. The pathogenic factors, preoperative diagnosis and postoperative prognosis of FCCS + AMT at 3 months were evaluated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29453698/corneal-collagen-cross-linking-for-the-management-of-mycotic-keratitis
#5
Elif Erdem, Ibrahim Inan Harbiyeli, Hazal Boral, Macit Ilkit, Meltem Yagmur, Reha Ersoz
PURPOSE: To evaluate the efficiency of corneal collagen cross-linking (CXL) in addition to topical voriconazole in cases with mycotic keratitis. DESIGN: Retrospective case series in a tertiary university hospital. PARTICIPANTS: CXL was performed on 13 patients with mycotic keratitis who presented poor or no response to topical voriconazole treatment. METHODS: The clinical features, symptoms, treatment results and complications were recorded retrospectively...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29453401/endothelial-smoothened-dependent-hedgehog-signaling-is-not-required-for-sonic-hedgehog-induced-angiogenesis-or-ischemic-tissue-repair
#6
Rajesh Gupta, Alexander R Mackie, Sol Misener, Lijun Liu, Douglas W Losordo, Raj Kishore
Sonic Hedgehog (Shh) signaling induces neovascularization and angiogenesis. It is not known whether the hedgehog signaling pathway in endothelial cells is essential to angiogenesis. Smoothened (Smo) transduces hedgehog signaling across the cell membrane. This study assessed whether endothelial Smoothened-dependent Shh signaling is required for Shh-mediated angiogenesis and ischemic tissue repair. Endothelial-specific smoothened knockout mice, eSmo Null were created using Cre-lox recombination system. eSmo Null mice had no observable phenotype at baseline and showed normal cardiac function...
February 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29453224/simple-limbal-epithelial-transplantation-slet-in-failed-cultivated-limbal-epithelial-transplantation-clet-for-unilateral-chronic-ocular-burns
#7
Sayan Basu, Sashwanthi Mohan, Swapnil Bhalekar, Vivek Singh, Virender Sangwan
AIMS: Cultivated limbal epithelial transplantation (CLET) fails in around 20%-30% of cases. This study aimed to report the clinical outcomes of autologous simple limbal epithelial transplantation (SLET) in eyes with recurrent unilateral limbal stem cell deficiency (LSCD) due to failure of CLET. METHODS: This was a prospective case series which included 30 eyes of 30 patients who underwent SLET between 2010 and 2016 after failure of one (n=24) or two (n=6) previous CLET procedures for chronic unilateral ocular burns...
February 16, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29453060/effect-of-selenium-on-penaeus-monodon-and-perna-viridis-enzyme-activities-and-histopathological-responses
#8
Avula Nagarjuna, Panneerselvam Karthikeyan, Dhandapani Mohan, Shambanagouda Rudragouda Marigoudar
The study was carried out to evaluate enzyme activities and histopathological changes due to the effect of acute and chronic definitive toxicity of selenium (Se) on the post larvae (PL) of giant tiger shrimp (Penaeus monodon), and green mussel (Perna viridis). The 96-h Median Lethal concentration (LC 50 ) for the PL of shrimp was 3.36 mg L -1 and the chronic value for the long-term survival endpoint in a 21-d exposure was 0.10 mg L -1 . The green mussel 96-h LC 50 was 28.41 mg L -1 and the chronic value for the long-term survival endpoint in a 30-d exposure was 3...
February 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29452891/effect-of-topical-application-of-2-lidocaine-gel-on-corneal-sensitivity-of-clinically-normal-equine-eyes
#9
Alain Regnier, Iris Berton, Didier Concordet, Jean-Yves Douet
OBJECTIVE: To assess the degree and duration of corneal anaesthesia provided by topical application of a non-ophthalmic 2% lidocaine gel in horses. STUDY DESIGN: Experimental, 'blinded', randomized prospective study. ANIMALS: Twelve adult horses without relevant ocular abnormalities. METHODS: Baseline corneal touch threshold (CTT) measurements were obtained bilaterally by use of a Cochet-Bonnet aesthesiometer just prior to topical treatment...
September 15, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29452886/shifting-the-igf-axis-an-age-related-decline-in-human-tear-igf-1-correlates-with-clinical-signs-of-dry-eye
#10
Roshni Patel, Meifang Zhu, Danielle M Robertson
OBJECTIVE: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1. DESIGN: Tear levels of IGF-1 were measured in 41 healthy, human volunteers without any reported symptoms of dry eye...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452534/co-culture-of-human-bone-marrow-mesenchymal-stem-cells-and-macrophages-attenuates-lipopolysaccharide-induced-inflammation-in-human-corneal-epithelial-cells
#11
Won-Yong Jeong, Ji-Hye Kim, Chan-Wha Kim
Dry eye syndrome (DES) is considered as an ocular surface inflammatory disease. Previous studies have shown inflammation plays an important role in the progression and onset of DES. Co-culture of human bone marrow mesenchymal stem cells (HBMSCs) and macrophages showed immunomodulatory effects via regulation of cytokine regulation. Thus, the aim of this study was to investigate the effect of the interaction of these cells on in vitro DES model. The conditioned media (CM) from macrophages, HBMSCs, and HBMSCs + macrophages were treated to human corneal epithelial cells, which showed significant reduction in IL-1α and IL-1β expression levels in HBMSCs + macrophages group...
February 16, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29452452/-effectivity-and-safety-of-a-modified-tip-design-in-torsional-phacoemulsification
#12
Sabine Schmidt, Sophie Hubich, Jan Markus Vetter, Christopher Wirbelauer
BACKGROUND: Torsional mode phacoemulsification results in more effective fragmentation of the nucleus due to a different movement of the phacotip. In this clinical study, we investigated the influence of a modified tip design and active fluidics on the efficacy of phacoemulsification and safety for the corneal endothelium. MATERIAL AND METHODS: We conducted a prospective randomized 2 : 1 study in which 40 patients were operated on with the mini-flared Kelman Tip using the Infiniti ® System (group 1), and 20 patients were operated on with the Intrepid ® Balanced Tip and the Centurion ® System...
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29452448/-fulminant-panendophthalmitis-from-streptococcus-pneumoniae-after-removal-of-corneal-suture
#13
Helga Reinshagen, Heinrich Gerding
No abstract text is available yet for this article.
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29452107/trabecular-meshwork-morphogenesis-a-comparative-analysis-of-wildtype-and-anterior-segment-dysgenesis-mouse-models
#14
Rebecca L Rausch, Richard T Libby, Amy E Kiernan
The trabecular meshwork (TM), a tissue residing in the iridocorneal angle of the eye, is the primary site of aqueous humor outflow and often develops abnormally in children with anterior segment dysgenesis (ASD). However, the cellular mechanisms underlying both normal and pathophysiological TM formation are poorly understood. Here, we improve the characterization of TM development via morphological and molecular analyses. We first assessed the TM of wild-type C57BL/6J mice at multiple time points throughout development (E15...
February 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29451997/poly-lactic-co-glycolic-acid-as-a-slow-release-drug-carrying-matrix-for-methotrexate-coated-onto-intraocular-lenses-to-conquer-posterior-capsule-opacification
#15
Stefan A Kassumeh, Christian M Wertheimer, Annabel von Studnitz, Anna Hillenmayer, Claudia Priglinger, Armin Wolf, Wolfgang J Mayer, Daniel Teupser, Lesca M Holdt, Siegfried G Priglinger, Kirsten H Eibl-Lindner
PURPOSE: Posterior capsule opacification (PCO) still represents the main long-term complication of cataract surgery. Research into pharmacologic PCO prophylaxis is extensive. One promising candidate drug is methotrexate (MTX). Our aim is to determine the in vitro feasibility of MTX-loaded poly(lactic-co-glycolic) (PLGA) biomatrices sprayed on intraocular lenses (IOLs) as a drug-delivery implant. METHODS: Hydrophilic and hydrophobic acrylic IOLs were spray-coated with MTX-loaded PLGA...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451741/non-invasive-optical-method-for-real-time-assessment-of-intracorneal-riboflavin-concentration-and-efficacy-of-corneal-cross-linking
#16
Giuseppe Lombardo, Valentina Villari, Norberto Liborio Micali, Nancy Leone, Cristina Labate, Maria Penelope De Santo, Marco Lombardo
Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV-A corneal cross-linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo-oxidated by UV-A light for generating additional cross-linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported a UV-A theranostic prototype device for performing corneal cross-linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29451275/cenegermin-for-the-treatment-of-neurotrophic-keratitis
#17
M Sacchetti, A Bruscolini, A Lambiase
The trigeminal nerve provides corneal sensitivity and trophic supply to corneal tissues. The impairment of corneal innervation leads to development of neurotrophic keratitis (NK). NK is a rare, degenerative corneal disease characterized by corneal hypo/anesthesia and development of nonhealing corneal epithelial defects and ulcers. NK is a challenging condition with high medical need due to the lack of approved treatments that can restore corneal integrity. Current treatment of NK aims at stimulating corneal healing and preventing disease progression...
November 2017: Drugs of Today
https://www.readbyqxmd.com/read/29450621/ngf-protects-corneal-retinal-and-cutaneous-tissues-cells-from-phototoxic-effect-of-uv-exposure
#18
Maria Luisa Rocco, Bijorn Omar Balzamino, Luigi Aloe, Alessandra Micera
PURPOSE: Based on evidence that nerve growth factor (NGF) exerts healing action on damaged corneal, retinal, and cutaneous tissues, the present study sought to assess whether topical NGF application can prevent and/or protect epithelial cells from deleterious effects of ultraviolet (UV) radiation. METHODS: Eyes from 40 young-adult Sprague Dawley rats and cutaneous tissues from 36 adult nude mice were exposed to UVA/B lamp for 60 min, either alone or in the presence of murine NGF...
February 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29450545/use-of-the-posterior-anterior-corneal-curvature-radii-ratio-to-improve-the-accuracy-of-intraocular-lens-power-calculation-eom-s-adjustment-method
#19
Mingue Kim, Youngsub Eom, Hwa Lee, Young-Woo Suh, Jong Suk Song, Hyo Myung Kim
Purpose: To evaluate the accuracy of IOL power calculation using adjusted corneal power according to the posterior/anterior corneal curvature radii ratio. Methods: Nine hundred twenty-eight eyes from 928 reference subjects and 158 eyes from 158 cataract patients who underwent phacoemulsification surgery were enrolled. Adjusted corneal power of cataract patients was calculated using the fictitious refractive index that was obtained from the geometric mean posterior/anterior corneal curvature radii ratio of reference subjects and adjusted anterior and predicted posterior corneal curvature radii from conventional keratometry (K) using the posterior/anterior corneal curvature radii ratio...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29450541/induction-of-ocular-complement-activation-by-inflammatory-stimuli-and-intraocular-inhibition-of-complement-factor-d-in-animal-models
#20
Maura A Crowley, Omar Delgado, Adrian Will-Orrego, Natasha M Buchanan, Karen Anderson, Bruce D Jaffee, Thaddeus P Dryja, Sha-Mei Liao
Purpose: Genome-wide association studies suggest a role for the complement system in age-related macular degeneration (AMD). We characterized ocular complement activation and evaluated a complement factor D (FD) neutralizing antibody. Methods: Mice were treated with toll-like receptor (TLR) ligands, intravitreal injection (IVT), or corneal debridement. Levels of complement proteins and mRNA were measured. A FD neutralizing antibody was administered IVT into eyes of rabbits that were challenged with LPS (lipopolysaccharide) administered intravenously...
February 1, 2018: Investigative Ophthalmology & Visual Science
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