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https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#1
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28087013/the-case-nephrotic-syndrome-with-corneal-opacities
#2
Abdullah Ozkok, Yesim Onal, Isin Kilicaslan, Seyhun Solakoglu, Huseyin Bayramlar, Ali Riza Odabas
No abstract text is available yet for this article.
February 2017: Kidney International
https://www.readbyqxmd.com/read/28086913/correction-of-irregular-and-induced-regular-corneal-astigmatism-with-toric-iol-after-posterior-segment-surgery-a-case-series
#3
Bence L Kolozsvári, Gergely Losonczy, Dorottya Pásztor, Mariann Fodor
BACKGROUND: Toric intraocular lens (IOL) implantation can be an effective method for correcting corneal astigmatism in patients with vitreoretinal diseases and cataract. Our purpose is to report the outcome of toric IOL implantation in two cases - a patient with scleral-buckle-induced regular corneal astigmatism and a patient with keratoconus following pars plana vitrectomy. As far as we are aware, there are no reported cases of toric IOL implantation in a vitrectomized eye with keratoconus nor of toric IOL implantation in patients with scleral-buckle-induced regular corneal astigmatism...
January 13, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28081301/ethanol-induces-platelet-apoptosis
#4
Lei Liu, Mengxing Chen, Lili Zhao, Qing Zhao, Renping Hu, Jie Zhu, Rong Yan, Kesheng Dai
BACKGROUND: Alcohol abuse incurs severe medical conditions, such as thrombocytopenia and hemorrhage, but the pathogenesis is not totally understood. Alcohol has been reported to induce apoptosis in eukaryotic cells, such as hepatocyte, nerve cell, corneal fibroblasts. However, it is still unclear whether alcohol induces platelet apoptosis. METHODS: Washed human platelets were pretreated with ethanol (EtOH), and apoptotic events and platelet function were detected...
January 12, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28081172/influence-of-corneal-opacity-on-intraocular-pressure-assessment-in-patients-with-lysosomal-storage-diseases
#5
Joanna Wasielica-Poslednik, Giuseppe Politino, Irene Schmidtmann, Katrin Lorenz, Katharina Bell, Norbert Pfeiffer, Susanne Pitz
AIMS: To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS: 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively included into this study. Outcome measures: Goldmann applanation tonometry (GAT); palpatory assessment of IOP; Goldmann-correlated intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH) assessed by Ocular Response Analyzer (ORA); central corneal thickness (CCT) and density assessed with Pentacam...
2017: PloS One
https://www.readbyqxmd.com/read/28081151/human-lacrimal-gland-gene-expression
#6
Vinay Kumar Aakalu, Sowmya Parameswaran, Mark Maienschein-Cline, Neil Bahroos, Dhara Shah, Marwan Ali, Subramanian Krishnakumar
BACKGROUND: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development...
2017: PloS One
https://www.readbyqxmd.com/read/28080168/corneal-melt-after-boston-keratoprosthesis-clinical-presentation-management-outcomes-and-risk-factor-analysis
#7
Soumaya Bouhout, Marie-Claude Robert, Sousans Deli, Mona Harissi-Dagher
PURPOSE: To determine the presentation, risk factors, and outcomes of keratolysis after Boston type I keratoprosthesis (B-KPro). METHODS: Retrospective chart review. RESULTS: A total of 16 (14%) of the 110 eyes (96 patients) which underwent B-KPro implantation developed keratolysis at an average 20 ± 11 months. Retroprosthetic membrane (RPM), infectious keratitis, and corneal dellen were identified in 31%, 25%, and 13% of corneal melts, respectively...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28079814/predictive-role-of-corneal-q-value-differences-between-nasal-temporal-and-superior-inferior-quadrants-in-orthokeratology-lens-decentration
#8
Juan Li, Cheng Yang, Wenjuan Xie, Guanrong Zhang, Xue Li, Shujun Wang, Xiaohong Yang, Jin Zeng
BACKGROUND: To investigate the association between pretreatment corneal parameters and orthokeratology lens decentration. METHODS: This retrospective study included a total of 108 eyes in 60 myopia patients, who were divided into a lens-decentration and a control group. Various pretreatment corneal parameters were analyzed by receiver operating characteristic curves (ROC curves), including corneal horizontal and vertical curvatures, diopter, corneal eccentricity (E-value), asphericity (Q-value), diameter, and astigmatism, to establish a reliable predictive model for orthokeratology lens decentration...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079694/eventual-endothelial-failure-after-initial-corneal-cleaning-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#9
Takahiko Hayashi, Itaru Oyakawa, Naoko Kato
No abstract text is available yet for this article.
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28079691/lutein-and-brilliant-blue-based-dye-for-donor-preparation-and-transplantation-in-descemet-membrane-endothelial-keratoplasty
#10
Sebastian Siebelmann, Mario Matthaei, Robert Hörster, Claus Cursiefen, Björn Bachmann
PURPOSE: Trypan blue (TB) is used for visualization of the endothelium-Descemet membrane graft during Descemet membrane endothelial keratoplasty (DMEK). However, TB is assumed to have a dose-dependent toxic effect on the corneal endothelium. We retrospectively compared a lutein/zeaxanthin and Brilliant Blue (LZ/BB)-based dye for preparation and transplantation of the graft in DMEK to TB. METHODS: In 20 patients, a dye composed of 1% LZ /0.025% BB was used, and in 22 patients, 0...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28079690/noncontact-evaluation-of-corneal-grafts-swept-source-fourier-domain-oct-versus-high-resolution-scheimpflug-imaging
#11
Eszter Szalai, Gábor Németh, Ziad Hassan, László Módis
PURPOSE: To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain anterior segment optical coherence tomography (SS-OCT) in comparison with a high-resolution Scheimpflug camera. METHODS: Keratometry (K) and elevation data of the anterior and posterior corneal surfaces, central corneal thickness, and anterior chamber depth were determined in 56 postkeratoplasty eyes (mean age: 59...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28079590/the-evaluation-of-corneal-fragility-after-uva-riboflavin-crosslinking
#12
Zhiwei Li, Yumeng Wang, Yanyun Xu, Vishal Jhanji, Chunxiao Zhang, Guoying Mu
PURPOSE: To evaluate the fragility of cornea after UVA/riboflavin crosslinking (CXL). METHODS: Sixty New Zealand rabbits received UVA/riboflavin crosslinking treatment (wavelength 365 nm, irradiance 3.0 mW/cm, and total dose 5.4 J/cm) on right eyes. Animals were sacrificed before and immediately after treatment (day 0), day 1, 3, 7, and 28 after treatment. A 4×10 mm corneal strip for biomechanical evaluation was harvested after sacrifice. The corneal fragility was evaluated by measurement of elongation rate, whereby the elongation rate equals elongation length/baseline length...
January 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28079022/lifitegrast-for-the-treatment-of-dry-eye-disease-results-of-a-phase-iii-randomized-double-masked-placebo-controlled-trial-opus-3
#13
Edward J Holland, Jodi Luchs, Paul M Karpecki, Kelly K Nichols, Mitchell A Jackson, Kenneth Sall, Joseph Tauber, Monica Roy, Aparna Raychaudhuri, Amir Shojaei
PURPOSE: Lifitegrast is a lymphocyte function-associated antigen-1 antagonist developed to reduce inflammation in dry eye disease (DED). We report the results of OPUS-3 (NCT02284516), a phase III study evaluating the efficacy and safety of lifitegrast versus placebo in participants with DED. DESIGN: Twelve-week, phase III, randomized, double-masked, multicenter, placebo-controlled study. PARTICIPANTS: Adults aged ≥18 years with Schirmer tear test (without anesthesia) ≥1 and ≤10 mm, corneal fluorescein staining score ≥2...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28078849/effects-of-carbomer-eye-drops-in-combination-with-orthokeratology-lens-in-treating-adolescent-myopia
#14
Y H Shi, L T Zhou, C X Zhang, Y Z Li, J Z Zhang, H M Zhou, Y G Li, T Liu, L L Zhang, L N Sun, Z Chen
To investigate the effects of carbomer eye drops (CED) during long-time wearing of overnight orthokeratology lens of adolescents with myopia, 260 teenagers with myopia treated in the Henan Provincial People’s Hospital from June 2012 to August 2014 and followed-up for more than 2 years were enrolled. All the patients underwent regular fitting of orthokeratology lens. They were divided into a CED (Vidisic) group (130 cases, 260 eyes treated with CED) and rewetting drops (RD) (Baushe and Lomb) group (130 cases, 260 eyes treated with RD)...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28076565/effect-of-corneal-biomechanical-properties-on-surgically-induced-astigmatism-and-higher-order-aberrations-after-cataract-surgery
#15
Mustafa Koç, Çağrı İlhan, Yaran Koban, Kemal Özülken, İrfan Durukan, Pelin Yılmazbaş
Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28074638/clinical-management-of-candida-albicans-keratomycosis-in-a-bottlenose-dolphin-tursiops-truncatus
#16
Claire A Simeone, John P Traversi, Jenny M Meegan, Carolina LeBert, Carmen M H Colitz, Eric D Jensen
OBJECTIVE: Corneal ulceration secondary to trauma commonly affects marine mammals, often with opportunistic secondary bacterial or fungal infections. This report characterizes the combined use of auriculopalpebral and ophthalmic nerve blocks, adipose-derived stem cells, and subconjunctival injections for successful treatment of corneal trauma and infection in dolphins. ANIMAL STUDIED: An 11-year-old, female bottlenose dolphin (Tursiops truncatus) presented with bilateral diffuse corneal opacities, which progressed to keratomycosis caused by Candida albicans...
January 11, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28073689/corneo-scleral-contact-lens-in-a-piggyback-system-for-keratoconus-a-case-report
#17
Esteban Porcar, Juan Carlos Montalt, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: We describe a case of fitting a corneo-scleral contact lens with a multi-aspheric geometry design (MAGD CScL) on top of a daily silicone hydrogel lens (piggyback system) for keratoconus management. METHODS: A 48-year-old man using soft toric contact lenses required an improvement in the unsatisfactory quality of his vision. He presented with bilateral asymmetric keratoconus with high myopia in the right eye (RE) and severe myopia in the left eye (LE). In addition, he had low vision in his LE because of a maculopathy...
January 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28072756/rapid-testing-for-creutzfeldt-jakob-disease-in-donors-of-cornea
#18
Luisa Gregori, Arthur Serer, Kristy L McDowell, Juraj Cervenak, David M Asher
BACKGROUND: Creutzfeldt-Jakob disease (CJD) has been accidentally transmitted by contaminated corneal transplants. Eye donors are not ordinarily tested for CJD, in part because an easy test is not available. We propose a relatively simple postmortem procedure to collect brain samples without performing full autopsy and show that a test currently marketed for veterinary diagnosis would offer an effective screening test. METHODS: We selected 6 brains from confirmed cases of human sporadic CJD and sampled each in triplicate (18 specimens), 28 control brains of individuals with non-CJD neurodegenerative diseases and 10 normal brains...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28070965/the-consequences-of-avian-ocular-trauma-histopathological-evidence-and-implications-of-acute-and-chronic-disease
#19
Bret A Moore, Leandro B C Teixeira, William E Sponsel, Richard R Dubielzig
OBJECTIVE: To present a description and categorization of the histopathological lesions in avian ocular trauma. ANIMAL STUDIED: Seventy-five birds diagnosed with ocular trauma at to the Comparative Ocular Pathology Laboratory of Wisconsin. PROCEDURES: Histological slides were reviewed, and the type of trauma was classified by cause into either (i) blunt trauma or (ii) penetrating trauma and by duration into (i) acute or (ii) chronic. RESULTS: Blunt trauma was the most common source of trauma, and the most frequent lesions were observed in the retina (91%), with 71% of retinas having a tear or detachment and 46% of retinas showing chronic degenerative changes...
January 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28069498/poly-glycerol-sebacate-poly-%C3%AE%C2%B5-caprolactone-blend-nanofibrous-scaffold-as-intrinsic-bio-and-immunocompatible-system-for-corneal-repair
#20
Sahar Salehi, Marta Czugala, Piotr Stafiej, Mohammadhossein Fathi, Thomas Bahners, Jochen S Gutmann, Bernhard B Singer, Thomas A Fuchsluger
: A major challenge in corneal tissue engineering and lamellar corneal transplantation is to develop synthetic scaffolds able to simulate the optical and mechanical properties of the native cornea. As a carrier, the graft scaffolds should provide the basis for anchorage, repair and regeneration. Although quite a number of scaffolds have been engineered to date, they have not been able to simultaneously recapitulate chemical, mechanical, and structural properties of the corneal extracellular matrix (ECM)...
January 6, 2017: Acta Biomaterialia
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