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https://www.readbyqxmd.com/read/28231267/accuracy-of-optical-biometry-combined-with-placido-disc-corneal-topography-for-intraocular-lens-power-calculation
#1
Giacomo Savini, Kenneth J Hoffer, Piero Barboni, Nicole Balducci, Domenico Schiano-Lomoriello, Pietro Ducoli
PURPOSE: To investigate the accuracy of a new optical biometer for intraocular lens (IOL) power calculation in eyes undergoing cataract surgery. METHODS: Consecutive eyes of patients undergoing cataract surgery with the same IOL model were enrolled in a prospective cohort study. Axial length (AL) and corneal power were measured with an optical biometer based on optical low-coherence interferometry and Placido-disc corneal topography. IOL power was calculated with the Hoffer Q, Holladay 1 and SRK/T formulas...
2017: PloS One
https://www.readbyqxmd.com/read/28230557/comparison-of-the-conventional-dresden-protocol-and-accelerated-protocol-with-higher-ultraviolet-intensity-in-corneal-collagen-cross-linking-for-keratoconus
#2
Moonjung Choi, Jiwon Kim, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To compare the accelerated corneal cross-linking (CXL) protocol and the conventional Dresden protocol in patients with keratoconus in terms of visual acuity, keratometric values, and topographic parameters. METHODS: Twenty-eight eyes of 25 patients with primary keratoconus were divided into 2 groups; 15 eyes in group 1 received CXL under the standard Dresden protocol (3 mW/cm for 30 min, dose 5.4 J/cm) and 13 eyes in group 2 were treated with the accelerated protocol (30 mW/cm for 3 min 40 s, dose 6...
February 22, 2017: Cornea
https://www.readbyqxmd.com/read/28228410/prediction-of-the-true-iol-position
#3
Sverker Norrby, Rolf Bergman, Nino Hirnschall, Yutaro Nishi, Oliver Findl
PURPOSE: To develop algorithms for preoperative estimation of the true postoperative intraocular lens (IOL) position to be used for IOL power calculation. SETTING: Moorfields Eye Hospital NHS Foundation Trust, London, UK. METHODS: Fifty patients were implanted randomly with a 3-piece IOL model in one eye and a 1-piece model in the other eye. Preoperatively, the IOLMaster was used to determine axial length, anterior chamber depth and mean corneal radius...
February 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28228409/clinical-and-demographic-study-of-microsporidial-keratoconjunctivitis-in-south-india-a-3-year-study-2013-2015
#4
Rohan Agashe, Naveen Radhakrishnan, Sayali Pradhan, Muthiah Srinivasan, Venkatesh N Prajna, Prajna Lalitha
AIM: To study the demographic profile, clinical features, treatment outcome and ocular morbidity of smear-positive microsporidial keratoconjunctivitis. METHODS: Retrospective case series of all patients with clinical features of microsporidial keratoconjunctivitis and who were smear positive for the same on Gram stain from January 2013 to December 2015. Demographic data, predisposing factors, microbiological investigations, clinical course and visual outcome were analysed...
February 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28228349/identification-of-prdm-genes-in-human-corneal-endothelium
#5
Kostadin Rolev, G O'Donovan Dominic, Christiana Georgiou, Rajan Madhavan, Alexandra Chittka
Corneal endothelial cells (CECs) are essential for maintaining corneal stromal hydration and ensuring its transparency, which is necessary for normal vision. Dysfunction of CECs leads to stromal decompensation, loss of transparency and corneal blindness. Corneal endothelium has low proliferative potential compared to surface epithelial cells leading to poor regeneration of CEC following injury or age related decline in cellular density. The mechanisms which control proliferation and differentiation of neural crest derived CEC progenitors are yet to be clearly elucidated...
February 19, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28226749/automatic-estimation-of-corneal-nerves-focused-tortuosities
#6
Pedro Guimaraes, Jeff Wigdahl, Alfredo Ruggeri, Pedro Guimaraes, Jeff Wigdahl, Alfredo Ruggeri, Alfredo Ruggeri, Jeff Wigdahl, Pedro Guimaraes
The correlation between corneal nerve tortuosity and pathology has been shown multiple times. However, because there isn't any defacto definition of tortuosity, reproducibility is poor. Indeed, many studies still rely on the manual observation and judgment of tortuosity. Recently, two distinct forms of corneal nerve tortuosity have been identified, describing either short-range or long-range directional changes. In this study we were able to develop automatic corneal nerve tortuosity measurements that correctly and independently represent these two tortuosity definitions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226740/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#7
F Scarpa, A Ruggeri, F Scarpa, A Ruggeri, A Ruggeri, F Scarpa
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226738/automatic-anterior-chamber-angle-structure-segmentation-in-as-oct-image-based-on-label-transfer
#8
Huazhu Fu, Yanwu Xu, Damon Wing Kee Wong, Jiang Liu, Mani Baskaran, Shamira A Perera, Tin Aung, Huazhu Fu, Yanwu Xu, Damon Wing Kee Wong, Jiang Liu, Mani Baskaran, Shamira A Perera, Tin Aung, Mani Baskaran, Tin Aung, Huazhu Fu, Yanwu Xu, Damon Wing Kee Wong, Jiang Liu, Shamira A Perera
The anterior chamber angle (ACA) plays an important role for diagnosis and treatment of angle-closure glaucoma. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging is qualitative and quantitative assessment for the ACA structure. In this paper, we propose a novel fully automatic segmentation method for anterior chamber angle structure in AS-OCT. In our method, the initial labels are obtained by using label transfer from the AS-OCT reference dataset. Then, these labels are refined and utilized as the landmarks to support the structure segmentation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226245/subconjunctival-injectable-dendrimer-dexamethasone-gel-for-the-treatment-of-corneal-inflammation
#9
Uri Soiberman, Siva P Kambhampati, Tony Wu, Manoj K Mishra, Yumin Oh, Rishi Sharma, Jiangxia Wang, Abdul Elah Al Towerki, Samuel Yiu, Walter J Stark, Rangaramanujam M Kannan
Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids...
February 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28225492/clinical-application-of-ticl-implantation-for-ametropia-following-deep-anterior-lamellar-keratoplasty-for-keratoconus-a-consort-compliant-article
#10
Qin Qin, Liping Yang, Zifang He, Zhenping Huang
BACKGROUND: This study aimed to investigate the clinical application of phakic toric intraocular collamer lens (TICL) implantation in treating ametropia following deep anterior lamellar keratoplasty (DALK) for patients with keratoconus, especially the effectiveness and safety of high astigmatism and indications of TICL implantation after corneal transplantation. METHODS: Using the self-controlled case series observation approach, 9 patients with ametropia (9 eyes) who underwent DALK surgery for keratoconus 1...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28224301/surgical-outcomes-of-perforated-and-unperforated-corneal-descemetocele
#11
Evin Singar Ozdemir, Ayse Burcu, Zuleyha Yalnız Akkaya, Firdevs Ornek
OBJECTIVE: To compare the surgical outcomes of amniotic membrane transplantation (AMT) and penetrating keratoplasty (PK) in perforated and non-perforated corneal descemetocele. METHOD: In this study, we retrospectively examined 48 eyes of 48 patients operated with AMT, and 32 eyes of 32 patients operated with PK for perforated and non-perforated descemetocele. RESULTS: There were no significant differences between the two groups with regard to age, sex, laterality, follow-up duration, cause of descemetocele, and localization (p > 0...
February 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28224218/-morphometric-characterization-of-the-subbasal-nerve-plexus-detection-and-analysis-of-networks-of-nerve-fibers
#12
K Winter, P Scheibe, R F Guthoff, S Allgeier, O Stachs
Confocal laser scanning microscopy is a versatile tool in medical research and enables noninvasive in vivo imaging of the corneal subbasal nerve plexus. The aim of this work is to provide a structured overview about the detection and quantification of nerve fibers of the subbasal nerve plexus from images acquired by confocal laser scanning microscopy. Relevant steps are explained and potential factors influencing the quality of the results are pointed out. Information obtained from the quantification of subbasal nerve fiber structure can be potentially used as clinical parameters in the context of diagnostics and therapy control of diabetic neuropathy...
February 21, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28223875/toxic-keratitis-after-use-of-wrongly-labeled-non-ophthalmic-medication
#13
Mohammad A Al-Amry, Nada Al-Abdan, Saleh A Al-Othaimeen
We present a 24-year-old female with trauma to her right eye. The patient was prescribed topical Tobramicin-dexamethasone eye drops but the pharmacy dispensed diclofenac diethyl amine ointment. The patient presented to the emergency room with lid edema, conjunctival injection and a corneal epithelial defect and toxic keratitis. The patient was successfully managed with copious irrigation, bandage contact lens and topical antibiotic therapy.
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28223775/a-comparison-of-three-different-corneal-marking-methods-used-to-determine-cyclotorsion-in-the-horizontal-meridian
#14
Hung-Yuan Lin, Yi-Ting Fang, Ya-Jung Chuang, Justin N Karlin, Hsin-Yang Chen, Szu-Yuan Lin, Pi-Jung Lin, Ming Chen
During toric intraocular lens (IOL) implantation, surgeons must take particular care to ensure that inaccurate preoperative measurement and intraoperative misalignment do not cause unexpected postoperative residual astigmatism. This retrospective, comparative case series study aimed to analyze the rotational deviation, or cyclotorsion, of three corneal marking methods: VERION digital marker (VDM; reference), horizontal slit beam marking (HSBM), and subjective direct visual marking (SDVM) on the table (using a bevel knife tip)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28223334/corneal-surface-glycosylation-is-modulated-by-il-1r-and-pseudomonas-aeruginosa-challenge-but-is-insufficient-for-inhibiting-bacterial-binding
#15
Amber L Jolly, Paresh Agarwal, Matteo M E Metruccio, David R Spiciarich, David J Evans, Carolyn R Bertozzi, Suzanne M J Fleiszig
Cell surface glycosylation is thought to be involved in barrier function against microbes at mucosal surfaces. Previously we showed that the epithelium of healthy mouse corneas becomes vulnerable to P. aeruginosa adhesion if it lacks the innate defense protein MyD88 (myeloid differentiation primary response gene 88), or after superficial injury by blotting with tissue paper. Here we explored their effect on corneal surface glycosylation using a metabolic label, tetra-acetylated N-azidoacetylgalactosamine (Ac4GalNAz)...
February 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28222481/effect-of-diquafosol-three-per-cent-ophthalmic-solution-on-tear-film-and-corneal-aberrations-after-cataract-surgery
#16
Hun Lee, Sang Myung Kim, Seonghee Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
BACKGROUND: The aim was to evaluate the effect of diquafosol on tear film parameters and corneal aberrations after cataract surgery. METHODS: This retrospective, comparative, observational case series included patients who underwent cataract surgery with or without peri-operative use of diquafosol three per cent ophthalmic solution. Patients in group I (31 eyes) were treated with diquafosol three per cent ophthalmic solution six times a day from one week before surgery to three months after surgery...
February 21, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28222145/cataract-surgery-causes-biomechanical-alterations-to-the-eye-detectable-by-corvis-st-tonometry
#17
Yoshitake Kato, Shunsuke Nakakura, Ryo Asaoka, Kanae Matsuya, Yuki Fujio, Yoshiaki Kiuchi
PURPOSE: Modern cataract surgery is generally considered to bring about modest and sustained intraocular pressure (IOP) reduction. However, the pathophysiological mechanism for this remains unclear. Moreover, a change in ocular biomechanical properties after surgery can affect the measurement of IOP. The aim of the study is to investigate ocular biomechanics, before and following cataract surgery, using Corvis ST tonometry (CST). PATIENTS AND METHODS: Fifty-nine eyes of 59 patients with cataract were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28221291/ophthalmic-manifestations-of-facial-dog-bites-in-children
#18
Emily M Bratton, Liliya Golas, Leslie A Wei, Brett W Davies, Vikram D Durairaj
PURPOSE: To characterize ophthalmic manifestations and periocular injuries of pediatric facial dog bites. METHODS: A retrospective review of all children younger than 18 years who sought medical attention after a dog bite to the face between January 1, 2003 and May 22, 2014 was performed at a large tertiary pediatric hospital. Data on type and location of injury, surgical intervention, and complications were collected. RESULTS: A total of 1,989 children aged 0...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28220849/the-long-term-anterior-segment-configuration-after-pediatric-cataract-surgery-and-the-association-with-secondary-glaucoma
#19
Ding Chen, Xian-Hui Gong, He Xie, Xue-Ning Zhu, Jin Li, Yun-E Zhao
Secondary glaucoma constitutes major sight-threatening complication of pediatric cataract surgery, yet the etiology remains unclear. The purpose of this study was to investigate the long-term anterior segment configuration and the association with secondary glaucoma in pediatric pseudophakia. Ultrasound biomicroscopy (UBM) was performed on 40 eyes of 26 children underwent pediatric cataract surgery and intraocular lens (IOL) implantation. The anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), central corneal thickness (CCT), structural abnormities, IOL position, IOP, and incidence of glaucoma were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220743/analysis-of-mutations-causing-familial-hypercholesterolaemia-in-black-south-african-patients-of-different-ancestr
#20
U K Ibe, R Whittall, S E Humphries, G Pilcher, F Raal
BACKGROUND: Familial hypercholesterolaemia (FH) is usually caused by mutations in three genes (LDLR, APOB and PCSK9). OBJECTIVE: To identify the spectrum of FH-causing mutations in black South African (SA) patients. METHODS: DNA samples of 16 unrelated South African FH patients with elevated low-density lipoprotein cholesterol levels, tendon xanthomas and corneal arcus (3 clinically homozygous FH and 13 heterozygous FH) of ethnic African origin were screened for mutations in the LDLR (coding region, promoter and intron/exon boundaries), APOB (part of exon 26) and PCSK9 genes (exon 7), using high-resolution melting...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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