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https://www.readbyqxmd.com/read/28549845/tomographic-analysis-of-anterior-posterior-and-total-corneal-refractive-power-changes-after-femtosecond-laser-assisted-keratotomy
#1
Franziska Löffler, Myriam Böhm, Michael Herzog, Kerstin Petermann, Thomas Kohnen
PURPOSE: To analyze the effect of penetrating femtosecond laser-assisted keratotomy (pFLAK) during laser lens surgery on anterior, posterior corneal astigmatism and total corneal refractive power (TCRP) astigmatism (CAant, CApost, CATCRP) measured with Scheimpflug tomography. DESIGN: Prospective, interventional case series. METHODS: This institutional study included 27 eyes of 23 patients (65 ± 8 years) with low to moderate CATCRP determined with Scheimpflug tomography (Pentacam HR) after penetrating femtosecond laser-assisted keratotomy (pFLAK) and laser lens surgery...
May 23, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28549842/mitochondrial-dysfunction-and-oxidative-stress-in-corneal-disease
#2
Neeru A Vallabh, Vito Romano, Colin E Willoughby
The cornea is the anterior transparent surface and the main refracting structure of the eye. Mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of inherited (e.g. Kearns Sayre Syndrome) and acquired corneal diseases (e.g. keratoconus and Fuchs endothelial corneal dystrophy). Both antioxidants and reactive oxygen species are found in the healthy cornea. There is increasing evidence of imbalance in the oxidative balance and mitochondrial function in the cornea in disease states...
May 23, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28549348/ocular-toxicities-associated-with-targeted-anticancer-agents-an-analysis-of-clinical-data-with-management-suggestions
#3
Chen Fu, Dan S Gombos, Jared Lee, Goldy C George, Kenneth Hess, Andrew Whyte, David S Hong
Ocular toxicities are among the most common adverse events resulting from targeted anticancer agents and are becoming increasingly relevant in the management of patients on these agents. The purpose of this study is to provide a framework for management of these challenging toxicities based on objective data from FDA labels and from analysis of the literature. All oncologic drugs approved by the FDA up to March 14, 2015, were screened for inclusion. A total of 16 drugs (12 small-molecule drugs and 4 monoclonal antibodies) were analyzed for ocular toxicity profiles based on evidence of ocular toxicity...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549095/klf4-plays-an-essential-role-in-corneal-epithelial-homeostasis-by-promoting-epithelial-cell-fate-and-suppressing-epithelial-mesenchymal-transition
#4
Anil Tiwari, Chelsea L Loughner, Sudha Swamynathan, Shivalingappa K Swamynathan
Purpose: The purpose of this study was to test the hypothesis that KLF4 promotes corneal epithelial (CE) cell fate by suppressing the epithelial-mesenchymal transition (EMT), using spatiotemporally regulated CE-specific ablation of Klf4 in Klf4Δ/ΔCE (Klf4LoxP/LoxP/Krt12rtTA/rtTA/Tet-O-Cre) mice. Methods: CE-specific ablation of Klf4 was achieved by feeding Klf4Δ/ΔCE mice with doxycycline chow. The wild-type (WT; normal chow-fed littermates) and the Klf4Δ/ΔCE histology was compared by hematoxylin and eosin-stained sections; EMT marker expression was quantified by quantitative PCR, immunoblots, and immunofluorescent staining; and wound healing rate was measured by CE debridement using Algerbrush...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28548209/improved-sampling-and-analysis-of-images-in-corneal-confocal-microscopy
#5
E L Schaldemose, F I Fontain, P Karlsson, J R Nyengaard
INTRODUCTION: Corneal confocal microscopy (CCM) is a noninvasive clinical method to analyse and quantify corneal nerve fibres in vivo. Although the CCM technique is in constant progress, there are methodological limitations in terms of sampling of images and objectivity of the nerve quantification. The aim of this study was to present a randomized sampling method of the CCM images and to develop an adjusted area-dependent image analysis. Furthermore, a manual nerve fibre analysis method was compared to a fully automated method...
May 26, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28546941/role-of-corneal-collagen-fibrils-in-corneal-disorders-and-related-pathological-conditions
#6
REVIEW
Hong-Yan Zhou, Yan Cao, Jie Wu, Wen-Song Zhang
The cornea is a soft tissue located at the front of the eye with the principal function of transmitting and refracting light rays to precisely sense visual information. Corneal shape, refraction, and stromal stiffness are to a large part determined by corneal fibrils, the arrangements of which define the corneal cells and their functional behaviour. However, the modality and alignment of native corneal collagen lamellae are altered in various corneal pathological states such as infection, injury, keratoconus, corneal scar formation, and keratoprosthesis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546932/removal-of-intraocular-foreign-body-in-anterior-chamber-angle-with-prism-contact-lens-and-23-gauge-foreign-body-forceps
#7
Yan-Ming Huang, Hua Yan, Jin-Hong Cai, Hai-Bo Li
AIM: To introduce a novel approach in removal of anterior chamber angle foreign body (ACFB) using a prism contact lens and 23-gauge foreign body forceps. METHODS: Data of 42 eyes of 42 patients who had undergone removal of ACFB using a prism contact lens and 23-gauge foreign body forceps from January 2008 to October 2013 were collected and analyzed. Twenty eyes in group A received the conventional approach by using toothed forceps through corneal limbus incision, and 22 eyes in group B underwent the novel method through the opposite corneal limbus incision...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546927/safety-of-hydroimplantation-in-cataract-surgery-in-patients-with-pseudoexfoliation-syndrome
#8
Tevfik Oğurel, Reyhan Oğurel, Zafer Onaran, Kemal Örnek
AIM: To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome. METHODS: This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens (IOL). Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1 (n=50), and hydroxypropylmethylcellulose (Eyevisc, Biotech, India) was used in group 2 (n=50)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546926/iontophoresis-assisted-corneal-crosslinking-using-0-1-riboflavin-for-progressive-keratoconus
#9
Hong-Zhen Jia, Xu Pang, Zheng-Jun Fan, Na Li, Gang Li, Xiu-Jun Peng
AIM: To report the clinical results of iontophoresis-assisted epithelium-on corneal crosslinking (I-CXL) using 0.1% riboflavin in distilled water for progressive keratoconus. METHODS: In this prospective clinical study, we examined 94 eyes of 75 patients with progressive keratoconus who were treated with I-CXL using 0.1% riboflavin in distilled water. Best correct visual acuity (BCVA), Scheimpflug tomography, corneal topography, anterior segment optical coherence tomography, intraocular pressure, and endothelial cell density were evaluated at baseline and 1, 3, 6, 12, and 24mo after I-CXL...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546925/comparison-of-corneal-biomechanics-in-sj%C3%A3-gren-s-syndrome-and-non-sj%C3%A3-gren-s-syndrome-dry-eyes-by-scheimpflug-based-device
#10
Qin Long, Jing-Yi Wang, Dong Xu, Ying Li
AIM: To compare the corneal biomechanics of Sjögren's syndrome (SS) and non-SS dry eyes with Corneal Visualization Scheimpflug Technology (CorVis ST). METHODS: Corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time (TBUT) and corneal staining score (CSS) were detected in 34 eyes of 34 dry eye patients with SS (SSDE group) and 34 dry eye subjects without SS (NSSDE group) using CorVis ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546919/cell-viability-and-extracellular-matrix-synthesis-in-a-co-culture-system-of-corneal-stromal-cells-and-adipose-derived-mesenchymal-stem-cells
#11
Ting Shen, Jiang Shen, Qing-Qing Zheng, Qiu-Shi Li, Hai-Lan Zhao, Lei Cui, Chao-Yang Hong
AIM: To investigate the impact of adipose-derived mesenchymal stem cells (ADSCs) on cell viability and extracellular matrix (ECM) synthesis of corneal stromal cells (CSCs). METHODS: ADSCs and CSCs were obtained from the corneas of New Zealand white rabbits and indirectly co-cultured in vitro. The proliferative capacity of CSCs in the different groups was assessed by CCK-8 assays. Annexin V-fluorescein isothiocyanate (FITC)/proliferation indices (PI) assays were used to detect the apoptosis of CSCs...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546880/kingella-kingae-keratitis-in-a-child-with-underlying-vernal-keratoconjunctivitis
#12
Salim Nurul-Laila, Khai-Siang Chai, Ahmad Tajudin Liza-Sharmini, Ismail Shatriah
Kingella kingae had rarely been reported as a causative organism for corneal ulcer and had not been described before in vernal keratoconjunctivitis (VKC). Generally regarded as commensals of respiratory tract particularly in young children, it had however been isolated from the corneal ulcer scraping of both adult and children. We report a case of bacterial ulcer with isolation of Kingella kingae from the corneal scraping in a young child with underlying VKC.
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28546694/cannula-associated-ocular-injuries-during-cataract-surgery-a-preventable-intraoperative-complication
#13
Darren Shu Jeng Ting, Chrisjan Dees, Christine Ellerton
Although rare, inadvertently dislodged cannula can occur during cataract surgery. We report two cases of cannula-associated ocular injury during stromal hydration of the main corneal incision despite the use of Luer-lock syringes. Case 1 suffered from an initially occult intraocular injury which led to a delayed presentation of vitreous prolapsing into the anterior chamber, presumed posterior capsular rupture, vitreous hemorrhage, and multiple retinal tears, which required a three-port pars plana vitrectomy and cryotherapy...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546691/toxic-anterior-segment-syndrome-outbreak-after-cataract-surgery-triggered-by-viscoelastic-substance
#14
AyşeGül Koçak Altıntaş, Meryem Yaşar Ciritoğlu, Özlem BeyazyıldıZ, Çiğdem Ülkü Can, Sibel Polat
PURPOSE: The purpose of this study is to present toxic anterior segment syndrome (TASS) outbreak at our clinic and discuss possible causes of TASS. MATERIALS AND METHODS: Thirty-four eyes of 34 patients developed TASS in a consecutive 2 weeks period were included in this study. Both anterior segment and fundus examinations were performed before and after uncomplicated cataract surgery. During the follow-up period, clinical features and all possible causes were evaluated including perioperative products and processing such as sterilization technique of surgical instruments, irrigating solutions, drugs, viscoelastic substance (VES), and intraocular lens...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546690/update-on-the-epidemiology-and-antibiotic-resistance-of-ocular-infections
#15
Darlene Miller
PURPOSE: The purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. METHODS: Trends in frequency and antibiotic-nonsusceptible profiles during an 11 year-period (2005-2015) were evaluated and compared with the 5-year Antibiotic Resistance Monitoring in Ocular Microorganism (ARMOR) study. RESULTS: Trends in the current review confirmed the continued high rates of fluoroquinolone nonsusceptbility circulating among ocular methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, methicillin-resistant S...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546688/collagen-cross-linking-for-microbial-keratitis
#16
Prashant Garg, Sujata Das, Aravind Roy
Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546470/ocular-changes-over-60-minutes-in-supine-and-prone-postures
#17
Allison P Anderson, Gautam Babu, Jacob G Swan, Scott D Phillips, Darin A Knaus, Christine M Toutain-Kidd, Michael E Zegans, Abigail M Fellows, Jiang Gui, Jay C Buckey
Some astronauts are returning from long duration spaceflight with structural ocular and visual changes. We investigated both the transient and sustained effects of changes in the direction of the gravity vector acting on the eye using changes in body posture. Intraocular pressure (IOP-Perkins tonometer), ocular geometry (axial length, corneal thickness, and aqueous depth-noncontact biometer), and the choroidal (volume and subfoveal thickness optical coherence tomography) was measured in 10 subjects (5M, 5F)...
May 25, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28546303/intraocular-minocycline-for-the-treatment-of-ocular-pythiosis
#18
Fátima Ros Castellar, Carmen Sobrino Jiménez, Almudena Del Hierro Zarzuelo, Alicia Herrero Ambrosio, Ana Boto de Los Bueis
PURPOSE: A case of ocular pythiosis successfully treated with surgery and intraocular and oral minocycline is reported. SUMMARY: A 30-year-old man who wore corrective contact lenses traveled to Brazil and Colombia where he swam in salt and fresh waters while wearing contact lenses. He sought treatment at an emergency department after 2 weeks of suffering with a painful corneal ulcer, redness, and loss of vision in his right eye that had been treated at other centers with ophthalmic moxifloxacin for 10 days and with fortified topical antibiotics (amikacin and vancomycin) for 2 days...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28545510/effect-of-bone-marrow-derived-mesenchymal-stem-cells-and-stem-cell-supernatant-on-equine-corneal-wound-healing-in-vitro
#19
Amanda B Sherman, Brian C Gilger, Alix K Berglund, Lauren V Schnabel
BACKGROUND: We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. METHODS: Bone marrow aspirates and eyes were collected from normal, euthanized horses with subsequent isolation and culture of BM-MSCs and corneal stromal cells. Corneal stromal cells were culture-expanded in the culture well of transwell plates and then treated with an autologous BM-MSC suspension (dose: 2...
May 25, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28545414/the-observation-during-small-incision-lenticule-extraction-for-myopia-with-corneal-opacity
#20
Shaowei Zhang, Haipeng Xu, Ke Zheng, Jing Zhao, Weijun Jian, Meiyan Li, Xingtao Zhou
BACKGROUND: To evaluate the feasibility and efficacy of small incision lenticule extraction (SMILE) in the treatment of myopia with corneal opacity. METHODS: To evaluate the treatment of myopia with corneal opacity, 9 patients (4 males, 5 females) who underwent SMILE were enrolled in this prospective clinical study. One eye of each patient was treated. The results of laser scanning and lenticule extraction were observed during the surgery, and the surgical videos were again reviewed after surgery...
May 25, 2017: BMC Ophthalmology
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