keyword
https://read.qxmd.com/read/38535998/targeting-mitochondrial-dysfunction-using-methylene-blue-or-mitoquinone-to-improve-skeletal-aging
#21
JOURNAL ARTICLE
Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, Shoshana Yakar
Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in vitro and in vivo settings. Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive oxygen species. To investigate the effect of long-term administration of MB on skeletal morphology, we administered MB to aged (18 months old) female C57BL/J6 mice, as well as to adult male and female mice with a genetically diverse background (UM-HET3)...
March 25, 2024: Aging
https://read.qxmd.com/read/38535961/investigation-of-the-association-between-air-pollution-and-non-alcoholic-fatty-liver-disease-in-the-european-population-a-mendelian-randomization-study
#22
JOURNAL ARTICLE
Jing Yang, Yaqi Zhang, Yin Yuan, Zhongyang Xie, Lanjuan Li
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver disease worldwide. At the same time, the relationship between air pollution and the likelihood of developing NAFLD has been a subject of debate due to conflicting findings in previous observational research. Our objective was to examine the potential correlation between air pollutant levels and the risk of NAFLD in the European population by employing a two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided the summary statistics for various air pollution indicators (PM2...
March 21, 2024: Toxics
https://read.qxmd.com/read/38535959/single-nucleotide-polymorphisms-associated-with-mercury-levels-and-neurological-symptoms-an-overview
#23
REVIEW
Jamila Alessandra Perini, Jessica Vilarinho Cardoso, Alana de Oliveira Knesse, Felipe Oliveira Pessoa-Silva, Ana Claudia Santiago de Vasconcellos, Daniel Escorsim Machado, Paulo Cesar Basta
Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations...
March 20, 2024: Toxics
https://read.qxmd.com/read/38535857/molecular-detection-of-candidatus-anaplasma-camelii-in-naturally-infected-dromedary-camels-camelus-dromedarius-in-abu-dhabi-emirate-united-arab-emirates-2019-2023
#24
JOURNAL ARTICLE
Hassan Zackaria Ali Ishag, Shameem Habeeba, El Tigani Ahmed El Tigani-Asil, Mohd Farouk Yuosf, Zulaikha Mohamed Abdel Hameed Al Hammadi, Abraham Nii Okai Commey, Hashel Talal Aboud Amer Bin Hraiz, Asma Abdi Mohamed Shah, Abdelmalik Ibrahim Khalafalla
The recent emergence of anaplasmosis in camels has raised global interest in the pathogenicity and zoonotic potential of the pathogen causing it and the role of camels as reservoir hosts. In the United Arab Emirates (UAE), molecular studies and genetic characterization of camel-associated Anaplasma species are limited. This study aimed to characterize molecularly Anaplasmataceae strains circulating in dromedary camels in the UAE. Two hundred eighty-seven whole-blood samples collected from dromedary camels across regions of the Abu Dhabi Emirate were received between 2019 and 2023 at the Abu Dhabi Agriculture and Food Safety Authority (ADAFSA) veterinary laboratories for routine diagnosis of anaplasmosis...
March 7, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535849/comparative-analysis-of-the-ovary-transcriptome-among-wanyue-black-and-yorkshire-gilts-using-rna-seq
#25
JOURNAL ARTICLE
Huibin Zhang, Shuo Chen, Yangguang Liu, Fan Xie, Haoyu Wen, Shiming Zhao, Xianrui Zheng, Yueyun Ding, Zongjun Yin, Xiaodong Zhang
Pubertal genetic variations between the indigenous Chinese Wanyue Black pig breed and the imported Yorkshire breed significantly impact their reproductive capacity. In order to identify the differentially expressed genes, gene networks, and metabolic pathways in ovary transcriptome of gilts, the serum hormone levels were analyzed by ELISA, and RNA-seq was performed to analyze ovarian genes. Our results reveal higher estradiol (E2) levels in Wanyue black gilts compared to Yorkshire gilts, while Yorkshire gilts exhibit elevated progesterone (P4) and GnRH levels...
March 4, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535607/metagenomic-detection-and-genetic-characterization-of-human-sapoviruses-among-children-with-acute-flaccid-paralysis-in-nigeria
#26
JOURNAL ARTICLE
Uwem Etop George, Temitope O C Faleye, Lander De Coninck, Sheriff Tunde Agbaje, Ijeoma Maryjoy Ifeorah, Bernard Anyebe Onoja, Elijah Igbekele Oni, Adebowale Oluseyi Olayinka, Toluwani Goodnews Ajileye, Arthur Obinna Oragwa, Toluwanimi Emmanuel Akinleye, Bolutife Olubukola Popoola, Oluwadamilola Gideon Osasona, Olaitan Titilola Olayinka, Oluwadamilola Adefunke George, Ahmed Iluoreh Muhammad, Isaac Komolafe, Adekunle Johnson Adeniji, Jelle Matthijnssens, Moses Olubusuyi Adewumi
Using a metagenomic sequencing approach on stool samples from children with Acute Flaccid Paralysis (AFP), we describe the genetic diversity of Sapoviruses (SaVs) in children in Nigeria. We identified six complete genome sequences and two partial genome sequences. Several SaV genogroups and genotypes were detected, including GII (GII.4 and GII.8), GIV (GIV.1), and GI (GI.2 and GI.7). To our knowledge, this is the first description of SaV infections and complete genomes from Nigeria. Pairwise identity and phylogenetic analysis showed that the Nigerian SaVs were related to previously documented gastroenteritis outbreaks with associated strains from China and Japan...
March 19, 2024: Pathogens
https://read.qxmd.com/read/38535419/unveiling-the-chaos-in-postural-control-in-adults-with-achondroplasia
#27
JOURNAL ARTICLE
Inês Alves, Maria António Castro, Sofia Tavares, Orlando Fernandes
BACKGROUND: Achondroplasia is a rare genetic skeletal condition characterized by disproportionate short stature. There is limited evidence on postural control in adults with achondroplasia and how lower limb lengthening (intervention) interacts with body dynamics. This study investigated sway variability during quiet standing in adults with achondroplasia with natural growth (N) and with lower limb lengthening (LL). METHODS: Sixteen adults performed bilateral/unilateral standing tasks...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535335/isobaric-tags-for-relative-and-absolute-quantitation-based-proteomics-analysis-revealed-proteins-involved-in-drought-response-during-the-germination-stage-in-faba-bean
#28
JOURNAL ARTICLE
Changyan Liu, Fangwen Yang, Li Li, Xuesong Han, Hongwei Chen, Aihua Sha, Chunhai Jiao
The faba bean, a significant cool-season edible legume crop, is susceptible to drought during the germination stage. Research regarding the genetic regulation of drought tolerance throughout this stage in the faba bean is limited. The differentially expressed proteins (DEPs) in faba beans between the drought-tolerant variety C105 and the drought-sensitive variant E1 during seed germination were identified in this work, accomplished through isobaric tags for relative and absolute quantitation (iTRAQ) analysis...
March 21, 2024: Metabolites
https://read.qxmd.com/read/38535317/integrative-multiomics-approach-to-skin-the-sinergy-between-individualised-medicine-and-futuristic-precision-skin-care
#29
REVIEW
Angelica Dessì, Roberta Pintus, Vassilios Fanos, Alice Bosco
The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut-brain-skin axis, especially associated with the modulation of neurotransmitters by the microbiota...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535219/chromosome-level-assembly-and-comparative-genomic-analysis-of-suillus-bovinus-provides-insights-into-the-mechanism-of-mycorrhizal-symbiosis
#30
JOURNAL ARTICLE
Jinhua Zhang, Mengya An, Yanliu Chen, Shengkun Wang, Junfeng Liang
Suillus bovinus is a wild edible ectomycorrhizal fungus with important economic and ecological value, which often forms an ectomycorrhiza with pine trees. We know little about the mechanisms associated with the metabolism and symbiosis of S. bovinus and its effects on the nutritional value. In this study, the whole-genome sequencing of S. bovinus was performed using Illumina, HiFi, and Hi-C technologies, and the sequencing data were subjected to genome assembly, gene prediction, and functional annotation to obtain a high-quality chromosome-level genome of S...
March 13, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535155/immunogenetic-background-of-chronic-lymphoproliferative-disorders-in-romanian-patients-case-control-study
#31
JOURNAL ARTICLE
Maria Tizu, Bogdan Calenic, Ion Maruntelu, Andreea Mirela Caragea, Adriana Talangescu, Larisa Ursu, Corina Rotarescu, Mariana Surugiu, Alexandra Elena Constantinescu, Ileana Constantinescu
BACKGROUND AND OBJECTIVES: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurrence and evolution of these pathologies are the HLA genes. The aim of this study is to analyze, for the first time, possible associations between chronic lymphoproliferative diseases and certain HLA alleles in the Romanian population. MATERIALS AND METHODS: This study included 38 patients with chronic lymphoproliferative disorders, diagnosed between 2021 and 2022 at Fundeni Clinical Institute, Bucharest, Romania, and 50 healthy controls...
February 23, 2024: Medical Sciences: Open Access Journal
https://read.qxmd.com/read/38535114/early-atherosclerosis-in-familial-hypercholesterolemia-patients-significance-of-vascular-markers-for-risk-stratification
#32
JOURNAL ARTICLE
Urte Aliosaitiene, Zaneta Petrulioniene, Egidija Rinkuniene, Antanas Mainelis, Jurate Barysiene, Urte Smailyte, Vaida Sileikiene, Aleksandras Laucevicius
BACKGROUND: Familial hypercholesterolemia (FH) is a genetic disorder that manifests as impaired low-density lipoprotein cholesterol (LDL-C) metabolism, resulting in lifelong exposure to high cholesterol levels and increased risk of cardiovascular disease (CVD). There is heterogeneity in cardiovascular risk for FH patients, so risk stratification is of utmost importance. The aim of this study was to evaluate the impact of increases in LDL-C and the impact of other CVD risk factors on vascular markers in the FH patient population...
March 13, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534951/ductal-adenocarcinoma-of-the-prostate-with-novel-genetic-alterations-characterized-by-next-generation-sequencing
#33
Alexandra Zara Rozalen, Jose Manuel Martin, Rithika Rajendran, Maneesh Jain, Victor E Nava
Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy...
March 19, 2024: Current Oncology
https://read.qxmd.com/read/38534789/genetic-insights-into-the-extremely-dwarf-hibiscus-syriacus-var-micranthus-complete-chloroplast-genome-analysis-and-development-of-a-novel-dcaps-marker
#34
JOURNAL ARTICLE
Soon-Ho Kwon, Hae-Yun Kwon, Hanna Shin
This study explored the chloroplast (cp) genomes of three Hibiscus syriacus (HS) specimens endemic to Korea possessing unique ornamental and conservation values: the dwarf H. syriacus var. micranthus (HSVM), renowned for its small stature and breeding potential; HS 'Tamra', a cultivar from Korea's southernmost islands, noteworthy for its distinctive beauty; and HS Natural Monument no. 521 (N.M.521), a specimen of significant lifespan and height. Given the scarcity of evolutionary studies on these specimens, we assembled and analyzed their cp genomes...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534785/cellular-organelle-related-transcriptomic-profile-abnormalities-in-neuronopathic-types-of-mucopolysaccharidosis-a-comparison-with-other-neurodegenerative-diseases
#35
JOURNAL ARTICLE
Karolina Wiśniewska, Lidia Gaffke, Magdalena Żabińska, Grzegorz Węgrzyn, Karolina Pierzynowska
Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) degradation. As a result, GAGs accumulate in lysosomes, impairing the proper functioning of entire cells and tissues. There are 14 types/subtypes of MPS, which are differentiated by the kind(s) of accumulated GAG(s) and the type of a non-functional lysosomal enzyme. Some of these types (severe forms of MPS types I and II, MPS III, and MPS VII) are characterized by extensive central nervous system disorders...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534779/autosomal-recessive-rod-cone-dystrophy-with-mild-extra-ocular-manifestations-due-to-a-splice-affecting-variant-in-bbs9
#36
Iris Deitch, Sofia Itskov, Daan Panneman, Aasem Abu Shtaya, Tal Saban, Yael Goldberg, Miriam Ehrenberg, Frans P M Cremers, Susanne Roosing, Tamar Ben-Yosef
Bardet-Biedl syndrome (BBS), one of the most common forms of syndromic inherited retinal diseases (IRDs), is characterized by the combination of retinal degeneration with additional extra-ocular manifestations, including obesity, intellectual disability, kidney disease, polydactyly and other skeletal abnormalities. We observed an Israeli patient with autosomal recessive apparently non-syndromic rod-cone dystrophy (RCD). Extra-ocular findings were limited to epilepsy and dental problems. Genetic analysis with a single molecule molecular inversion probes-based panel that targets the exons and splice sites of 113 genes associated with retinitis pigmentosa and Leber congenital amaurosis revealed a homozygous rare missense variant in the BBS9 gene (c...
March 18, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534778/genetic-and-environmental-factors-in-autoimmune-thyroid-disease-exploring-associations-with-selenium-levels-and-novel-loci-in-a-latvian-cohort
#37
JOURNAL ARTICLE
Sabine Upmale-Engela, Ieva Vaivode, Raitis Peculis, Helena Litvina, Tatjana Zake, Andrejs Skesters, Deniss Gogins, Vita Rovite, Ilze Konrade
The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production...
March 17, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534763/unveiling-the-ovarian-cell-characteristics-and-molecular-mechanism-of-prolificacy-in-goats-via-single-nucleus-transcriptomics-data-analysis
#38
JOURNAL ARTICLE
Sanbao Zhang, Yirong Wei, Xiaotong Gao, Ying Song, Yanna Huang, Qinyang Jiang
Increases in litter size, which are influenced by ovulation, are responsible for between 74% and 96% of the economic value of genetic progress, which influences selection. For the selection and breeding of highly prolific goats, genetic mechanisms underlying variations in litter size should be elucidated. Here, we used single-nucleus RNA sequencing to analyze 44,605 single nuclei from the ovaries of polytocous and monotocous goats during the follicular phase. Utilizing known reference marker genes, we identified 10 ovarian cell types characterized by distinct gene expression profiles, transcription factor networks, and reciprocal interaction signatures...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#39
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534745/subjective-cognitive-decline-and-genetic-propensity-for-dementia-beyond-apolipoprotein-%C3%AE%C2%B5-4-a-systematic-review
#40
REVIEW
Stefanos N Sampatakakis, Maria Roma, Nikolaos Scarmeas
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially. Therefore, we aimed to summarize existing data regarding genetic factors related to SCD, beyond APOE ε4, in order to improve our current understanding of SCD...
March 2, 2024: Current Issues in Molecular Biology
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