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A B Kon'kova-Reidman
AIM: To study the semiotics of neurological lesions in patients with tick-borne encephalitis, Ixodes tick-borne borreliosis (ITBB) and mixed infection (MI), their immunopathogenesis, and the possibilities of current pathogenetic pharmacological correction. SUBJECTS AND METHODS: A total of 220 patients with tick-borne encephalitis, ITBB, and MI concurrent with the syndromes of central nervous system lesions were examined. The immunological studies encompassed the examination of mononuclear cells in the cerebrospinal fluid (CSF), the population and subpopulation composition of lymphocytes, and nitroxidergic processes in the serum and CSF from the total level of final stable nitric oxide metabolites...
2016: Terapevticheskiĭ Arkhiv
J Cymerys, A Słońska, M Chodkowski, M Przybylski, M W Bańbura
Adenoviral infections of the central nervous system are rare, but they are characteristic for their high mortality rate. People with impaired immunity and children are particularly vulnerable. A few reports of neuroinfections caused by adenoviruses are found in literature. In this study the tropism of the human adenoviruses type 4, 5, 7 to primary cultures of murine neurons and the influence of infection on the neuron morphology and actin cytoskeleton was examined. The A549 non-small-cell lung cancer cell line was used as a reference line...
2016: Acta Virologica
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
Jana Elsterova, Martin Palus, Jana Sirmarova, Jan Kopecky, Hans Helmut Niller, Daniel Ruzek
Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing antibodies in two IVIG lots originating from the same manufacturer, and tested their ability to treat a lethal TBEV-infection in a mouse model...
November 18, 2016: Ticks and Tick-borne Diseases
Elena Nikolaevna Krotkova, Innesa Vladimirovna Babaeva, Michail Bogutskiy, Vladimir Maksimovich Tsyrkunov
THE PURPOSE OF THE STUDY: to present epidemiological features and clinical manifestations of TBE in patients residing in Grodno region. MATERIALS AND METHODS: A retrospective analysis of 124 case histories of patients with TBE in “Grodno Regional Infectious Clinical Hospital” in 2010 – 2014. RESULTS: Epidemiological features of tick-borne encephalitis are the prevalence of the transmission mechanism of contamination (57.3%), involvement of residents of Grodno and Grodno region (54...
2016: Przegla̧d Epidemiologiczny
Tomáš Macháček, Lucie Panská, Hana Dvořáková, Petr Horák
BACKGROUND: Helminth neuroinfections represent a serious health problem, but host immune mechanisms in the nervous tissue often remain undiscovered. This study aims at in vitro characterization of the response of murine astrocytes and microglia exposed to Trichobilharzia regenti which is a neuropathogenic schistosome migrating through the central nervous system of vertebrate hosts. Trichobilharzia regenti infects birds and mammals in which it may cause severe neuromotor impairment. This study was focused on astrocytes and microglia as these are immunocompetent cells of the nervous tissue and their activation was recently observed in T...
November 14, 2016: Parasites & Vectors
Adelina Stoyanova, Ivanka Nikolova, Gerhard Pürstinger, Georgi Dobrikov, Vladimir Dimitrov, Stefan Philipov, Angel S Galabov
BACKGROUND: Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist, mainly due to the development of drug resistance. We investigated the combination effects of enterovirus replication inhibitors in order to limit this process. In previous studies, we showed the efficacy of consecutive alternating administration of the triple combinations disoxaril/guanidine/oxoglaucine and pleconaril/guanidine/oxoglaucine against coxsackievirus B1 infection in newborn mice...
November 4, 2016: Antiviral Chemistry & Chemotherapy
M Ishwarya, R T Narendhirakannan
Neurological disorders are diseases of the brain, the spine, and the nerves that connect them. There are more than 600 diseases of the nervous system, such as brain tumors, epilepsy, Parkinson's disease, and stroke as well as less familiar ones such as frontotemporal dementia, Alzheimer's disease, and other dementias; cerebrovascular diseases including stroke, migraine, and other headache disorders; multiple sclerosis; neuroinfections; brain tumors; traumatic disorders of the nervous system such as brain trauma; and neurological disorders as a result of malnutrition...
2016: Advances in Neurobiology
Takatsugu Abe, Tomohiro Kawaguchi, Miki Fujimura, Teiji Tominaga
A 69-year-old woman presented with anorexia, fever, and vomiting. The patient was not a compromised host. She was finally diagnosed with <i>Listeria</i> meningitis and treated with ampicillin and gentamicin. However, her condition worsened over time. Non-contrast head CT showed ventricular dilatation. As a result, continuous right ventricular drainage was performed. Non-contrast MRI revealed hydrocephalus due to stenosis of the fourth ventricle. She underwent endoscopic third ventriculostomy(ETV)to improve cerebrospinal fluid circulation...
September 2016: No Shinkei Geka. Neurological Surgery
D Pícha, L Moravcová, D Smíšková
The study evaluates the clinical significance of CXCL13 (leukocyte chemoattractant synthesized in CSF ) in Lyme neuroborreliosis (LNB) and other aseptic CNS infections. 244 patients with symptoms of neuroinfection and/or LNB were divided into groups: A - patients with LNB-positive antibodies in serum and CSF (96) or CSF only (14); B - patients with aseptic non-borrelial neuroinfections (82); C - negative controls (52). Group A was divided into A1-A4 according to pleocytosis in CSF and AIIgG positivity. The highest CSF CXCL13 concentrations (max...
September 15, 2016: Journal of the Neurological Sciences
L Krbková, J Bednářová, Z Čermáková
BACKGROUND: The purpose of the study was to evaluate new 3rd-generation test kits, EIA Borrelia recombinant IgM and IgG (TestLine, Brno, Czech Republic), in serum and cerebrospinal fluid (CSF) of children with Lyme neuroborreliosis. METHODS: Comparison of three tests was used: the whole-cell EIA from Borrelia garinii (EIA 1) was compared with the EIA using recombinant antigens (EIA 2) and immunoblot. In total, 364 samples of serum and CSF were examined. Eighty-six paired sera and CSF samples were evaluated in the first group of children with Lyme neuroborreliosis...
December 0: Epidemiologie, Mikrobiologie, Imunologie
Angel S Galabov, Ivanka Nikolova, Ralitsa Vassileva-Pencheva, Adelina Stoyanova
Human enteroviruses distributed worldwide are causative agents of a broad spectrum of diseases with extremely high morbidity, including a series of severe illnesses of the central nervous system, heart, endocrine pancreas, skeleton muscles, etc., as well as the common cold contributing to the development of chronic respiratory diseases, including the chronic obstructive pulmonary disease. The above mentioned diseases along with the significantly high morbidity and mortality in children, as well as in the high-risk populations (immunodeficiencies, neonates) definitely formulate the chemotherapy as the main tool for the control of enterovirus infections...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Dawid Szpecht, Dagmara Frydryszak, Norbert Miszczyk, Marta Szymankiewicz, Janusz Gadzinowski
INTRODUCTION: Intraventricular hemorrhage (IVH) is mostly documented in premature infants, and the younger the gestational age, the more often it occurs. IVH is very rarely reported in full-term neonates. CASE REPORT: Retrospective analysis was performed in 35939 full-term neonates, who were born in the Clinical Hospital of Gynecology and Obstetrics at the University of Medical Sciences in Poznań. Clinical data were retrieved from their medical records. We report a case series of 2 term newborns, who developed severe IVH grade 3 and 4 with no evidence of asphyxia, neuroinfection, TORCH infections, coagulation disorders and trombocytopenia, metabolic disorders, arteriovenous malformations, and selected genetic abnormalities (factor V Leiden 1601G > A polymorphism and MTHFR 677C > T; 1298A > C polymorphisms)...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Anna Moniuszko-Malinowska, Piotr Czupryna, Justyna Dunaj, Joanna Zajkowska, Agnieszka Siemieniako, Sławomir Pancewicz
In recent years emergence of new infectious diseases and the growing spread of pathogens to new areas is observed. Most of these pathogens are zoonotic viruses and their transmission route is from animals to humans and vice versa. These so called emerging and re-emerging pathogens that were present previously only in Africa and Asia are becoming a threat to European countries. These include, e.g. West Nile virus and USUTU virus. The aim of the study is to present the clinical course of infections caused by WVN and USUTU, diagnostic and therapeutic possibilities and, above all, the current epidemiological situation of these infections in the world...
2016: Przegla̧d Epidemiologiczny
Beata Kuklińska, Anna Moniuszko-Malinowska, Robert Mróz, Sławomir Pancewicz, Joanna Zajkowska
Introduction. The diagnosis of lung cancer may still be difficult due to the fact that the first symptoms very often mimic symptoms of other diseases. Case Presentation. In this paper we present two cases, in which initial diagnosis of neuroinfection delayed proper diagnosis. Conclusion. Based on our experience we concluded that neurological symptoms in the area endemic for tick-borne diseases suggesting neuroinfection require careful differential diagnosis. Moreover, neurological symptoms in heavy smokers may be associated with metastases of lung cancer...
2016: Case Reports in Infectious Diseases
Marta Nesteruk, Anna Kurdyła, Tomasz Nesteruk, Małgorzata Dorobek
Posterior reversible encephalopathy syndrome (PRES) is a set of neurological symptoms including impaired consciousness, cognitive disorders, seizures, blurred vision, dizziness and headache. The symptoms are closely related to the location of pathological changes in the brain; bilateral occipitto-parietal region is most often affected. Both focal neurological symptoms and encephalopathy are usually transient. We present the case of 64-year-old woman with PRES. She suffered from many internal diseases and was admitted to the hospital due to impaired consciousness, speech disorders, balance disorders...
April 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Rashmi Kumar, Anirban Basu, Subrata Sinha, Manoj Das, Piyush Tripathi, Amita Jain, Chandrakanta Kumar, Virendra Atam, Saima Khan, Amit Shanker Singh
BACKGROUND: Acute encephalitis syndrome (AES) is a public health problem in India. Neuroinfections are believed to be the most important etiology. Minocycline is a semisythetic tetracycline having excellent penetration into cerebrospinal fluid, established neuroprotective and antiviral properties besides action on nonviral causes of AES. It has been shown to be effective in animal model of Japanese encephalitis (JE). A randomized, controlled trial of nasogastric/oral minocycline in JE and AES at a single centre in Uttar Pradesh, northern India, was therefore conducted...
2016: BMC Infectious Diseases
Solène Debaisieux, Vesela Encheva, Probir Chakravarty, Ambrosius P Snijders, Giampietro Schiavo
Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. Neurotrophins and their receptors are conveyed via fast axonal retrograde transport of signaling endosomes to the soma, where they elicit transcriptional responses. Despite the essential roles of signaling endosomes in neuronal differentiation and survival, little is known about their molecular identity, dynamics, and regulation. Gaining a better mechanistic understanding of these organelles and their kinetics is crucial, given the growing evidence linking vesicular trafficking deficits to neurodegeneration...
February 2016: Molecular & Cellular Proteomics: MCP
Piotr Czupryna, Anna Moniuszko-Malinowska, Sławomir Pancewicz, Adam Garkowski, Joanna Gościk, Agnieszka Siemieniako, Joanna Zajkowska
PURPOSE: We evaluated the clinical picture of patients hospitalized with Lyme disease (LD). Additionally, we analyzed the possible cause of sudden rise in LD incidence in Poland. MATERIALS AND METHODS: We retrospectively analyzed medical documentation of patients admitted to the Department of Infectious Diseases and Neuroinfections, Medical University in Bialystok in 2013 with suspicion of LD. The collected data featured patients' age, gender, occupation, symptoms, clinical form of LD and final diagnosis...
March 2016: Advances in Medical Sciences
Katarzyna Chwiejczak, Marcin Wołowiec, Iwona Grabska-Liberek
This is a case report of a 53-year-old man, who presented in the Department of Ophthalmology with signs of orbital cellulitis on the right side, which developed over a few days following an injury. Computed tomography revealed inflammatory infiltration of the orbital soft tissues, penetrating to the sella turcica. Orbital swab and blood cultures revealed the presence of Enterobacter and Peptostreptococcus spp. as well as Stenotrophomonas maltophilia, respectively. Review of the literature relevant to the presented case was performed based on the PubMed databasesearch, using the following keywords: intraorbital foreign body, orbital cellulitis, neuroinfection, Stenotrophomonas maltophiia...
2015: Klinika Oczna
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