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https://www.readbyqxmd.com/read/28933328/-local-application-of-tranexamic-acid-in-total-hip-arthroplasty-decreases-blood-loss-and-consumption-of-blood-transfusion
#1
J Lošťák, J Gallo, M Večeřa, J Špička, K Langová
PURPOSE OF THE STUDY The primary aim of our study was to identify the effects of local application of tranexamic acid (TXA, Exacyl) on the amount of postoperative blood loss and blood transfusion requirement in primary total hip arthroplasty. We also recorded the levels of postoperative haemoglobin and its drop in early period after surgery. In each patient, we monitored in detail the incidence of early complications (haematoma, wound exudate). Lastly, the economic aspect of TXA administration was also taken into account...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28922709/non-drainage-versus-drainage-in-tourniquet-free-knee-arthroplasty-a-prospective-trial
#2
Kai Zhou, Haoyang Wang, Jinglong Li, Duan Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: It is still unknown whether drainage is necessary and non-drainage is safe and acceptable after tourniquet-free total knee arthroplasty (TKA). We aim to investigate whether non-drainage use is accepted in TKA that is performed without a tourniquet. METHODS: Clinical data of 80 adult patients who did or did not receive drainage in our centres from August 2015 to December 2015 were prospective investigated. RESULTS: The drainage group exhibited reduced hidden blood loss (47...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28844914/comparison-of-the-total-and-hidden-blood-loss-in-patients-undergoing-open-and-minimally-invasive-transforaminal-lumbar-interbody-fusion
#3
Hui Zhang, Ze-Xin Chen, Ze-Ming Sun, Chao Jiang, Wen-Fei Ni, Yan Lin, Yao-Sen Wu
PURPOSE: This study examined the volume of hidden blood loss (HBL) and compared perioperative blood loss between minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) and open transforaminal lumbar interbody fusion (O-TLIF). METHODS: Forty-eight patients who were treated with MI-TLIF and 59 patients treated with O-TLIF were enrolled in this study. Patient's height, weight, and preoperative and postoperative hematocrit (Hct) were recorded and used to calculate total blood loss (TBL) according to Gross's formula...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28810918/tranexamic-acid-reduces-hidden-blood-loss-in-the-treatment-of-intertrochanteric-fractures-with-pfna-a-single-center-randomized-controlled-trial
#4
Jinlai Lei, Binfei Zhang, Yuxuan Cong, Yan Zhuang, Xing Wei, Yahui Fu, Wei Wei, Pengfei Wang, Shiming Wen, Hai Huang, Hu Wang, Shuang Han, Shuguang Liu, Kun Zhang
BACKGROUND: Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture. METHODS: A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i...
August 15, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28741030/hidden-and-overall-haemorrhage-following-minimally-invasive-and-open-transforaminal-lumbar-interbody-fusion
#5
Yang Yang, Liangming Zhang, Bin Liu, Mao Pang, Peigen Xie, Zihao Chen, Wenbin Wu, Feng Feng, Limin Rong
BACKGROUND: Hidden haemorrhage has been proved to be significant in joint surgery. However, when referring to lumbar interbody fusion, it is often ignored because of its invisibility. This randomized controlled study aimed to calculate and compare hidden haemorrhage following minimally invasive and open transforaminal lumbar interbody fusion (MIS-TLIF and open TLIF). Meanwhile, its clinical significance was also analyzed. MATERIALS AND METHODS: A total of 41 patients were included in this study, then they were randomized to receive MIS-TLIF or open TLIF, 21 and 20, respectively...
July 24, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28723749/effects-of-sealing-the-intramedullary-femoral-canal-in-total-knee-arthroplasty-a-randomized-study
#6
RANDOMIZED CONTROLLED TRIAL
Xu Li, Xiang-Bei Qi, Xue Han, Wei Wang, Jian-Ning Liu, Ji-Chao Guo, Zhi-Yong Li
BACKGROUND: This study investigates the clinical effects of sealing the femoral canal by intramedullary alignment instrumentation in total knee arthroplasty (TKA). METHODS: One hundred twenty consecutive patients with knee osteoarthritis, who underwent unilateral TKA, were enrolled in the study and equally randomized into 2 groups: the sealing group and the control group. In the sealing group, the femoral canal was sealed with autogenous bone and cement using intramedullary alignment instrumentation, while the femoral hole was left open for patients in the control group...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28697863/intra-articular-application-is-more-effective-than-intravenous-application-of-tranexamic-acid-in-total-knee-arthroplasty-a-prospective-randomized-controlled-trial
#7
Jin Wang, Qiaojie Wang, Xianlong Zhang, Qi Wang
BACKGROUND: The optimal administration route of tranexamic acid (TXA) in total knee arthroplasty (TKA), and the effect of TXA on hidden blood loss and total blood loss are undetermined. The purpose of this study was to compare the effectiveness of intravenous versus intra-articular application of tranexamic acid in patients undergoing knee arthroplasty. METHODS: A total of 150 patients undergoing primary unilateral total knee arthroplasty were randomly distributed to 3 groups (IV, intra-articular, and control group; each 50 patients) and administrated TXA (1 g IV and 50 mL intra-articular saline, 1 g intra-articularly and 50 mL intra-articular saline, and 0 g and 50 mL intra-articular saline, respectively)...
June 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28693817/investigation-of-perioperative-hidden-blood-loss-of-unstable-intertrochanteric-fracture-in-the-elderly-treated-with-different-intramedullary-fixations
#8
Xu Yang, Qiang Wu, Xin Wang
OBJECTIVE: Our aim was to investigate perioperative hidden blood loss (PHBL) of unstable intertrochanteric fracture (UIF) in the elderly treated with different intramedullary fixations. PATIENTS AND METHODS: 120 consecutive elderly patients with UIF treated by intramedullary nails between January 2013 and September 2016 were enrolled in the retrospective study, including 52 patients (mean age 79.6±6.3) for the Third generation Gamma Nail (TGN), 51 patients (mean age 79...
June 24, 2017: Injury
https://www.readbyqxmd.com/read/28567578/the-efficacy-and-safety-of-multiple-dose-intravenous-tranexamic-acid-on-blood-loss-following-total-knee-arthroplasty-a-randomized-controlled-trial
#9
Yiting Lei, Jinwei Xie, Bin Xu, Xiaowei Xie, Qiang Huang, Fuxing Pei
PURPOSE: To assess the efficacy and safety of multiple-dose intravenous tranexamic acid (IV-TXA) on blood loss following total knee arthroplasty (TKA). METHODS: One hundred fifty nine patients received one bolus of IV-TXA before skin incision and two boluses three and six hours later (group A), or another bolus nine hours later (group B), or another two boluses nine and 12 hours later (group C). The primary outcomes were total blood loss (TBL), hidden blood loss (HBL), and maximum haemoglobin (Hb) drop...
May 31, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28565865/alterations-of-caspr2-and-nav1-6-on-myelinated-axon-damage-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#10
Weihua Liang, Weiwei Zhang, Shifu Zhao, Hua Liang, Jinli Zhang, Luyan Wang
Myelinated axons require the correct localization of key proteins that are essential for nerve conduction and cognitive function. Little is known regarding the altered expression of contactin-associated protein 2 (Caspr2) at the juxtaparanodal regions and Nav1.6 at the node of Ranvier in response to chronic cerebral hypoperfusion (CCH). The aim of the present study was to examine the alterations in the key protein of myelinated axons and the potential mechanisms that may follow CCH. We established a rat model of CCH by controllable partial narrowing of bilateral common carotid arteries...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28538384/efficacy-and-safety-of-intravenous-tranexamic-acid-administration-in-patients-undergoing-hip-fracture-surgery-for-hemostasis-a-meta-analysis
#11
Pei Zhang, Jinshan He, Yongchao Fang, Pengtao Chen, Yuan Liang, Jingcheng Wang
BACKGROUND: Patients undergoing hip fracture surgery frequently require blood transfusion. Tranexamic acid (TXA) has been widely used to decrease blood loss and transfusion rates in joint replacement surgery. Therefore, we conducted a meta-analysis to evaluate efficacy and safety of intravenous TXA administration in patients suffering from hip fractures. METHODS: Electronic databases were searched before December 2016 by 2 independent reviewers, including Cochrane Library, EMBASE, PubMed, Web of Science, the Chinese Biomedical Literature database, and the China National Knowledge Infrastructure databases...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28501110/arachidonic-acid-causes-hidden-blood-loss-like-red-blood-cell-damage-through-oxidative-stress-reactions
#12
Tao Yuan, Yu Cong, Jia Meng, Hong Qian, Wei Ye, Wen-Shuang Sun, Jian-Ning Zhao, Ni-Rong Bao
BACKGROUND: Hidden blood loss (HBL) often occurs in the prosthetic replacement for joint, but the mechanism is still not clear. MATERIALS AND METHODS: This study tried to establish an animal model of HBL by injecting arachidonic acid (AA) into the Sprague-Dawley rats. Different concentrations of AA were injected into the tail veins of the rats, and blood samples were collected before and after administration at 24, 48, and 72 h. A complete blood count was obtained by to find the hemoglobin (Hb) and red blood cell (RBC) count changes...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28416833/-diagnosis-and-treatment-for-the-basicervical-fractures-of-the-trochanteric-region
#13
T C Zhang, Z S Zhang, F Zhou, Y Tian, H Q Ji, Y Guo, Y Lv, Z W Yang, G J Hou
OBJECTIVE: To evaluate the rate of basicervical fractures and document their diagnosis and treatment. METHODS: From January 2005 to May 2016, 28 basicervical fractures of the 832 trochanteric fractures were collected and evaluated. The patients were treated with multiple screws, dynamic hip screw (DHS), intramedullary nail. Via the operation time, postoperative hospitalization, loss of blood duration the operation, hidden blood loss, total blood loss, mean union time and the final follow-up Harris hip score, the characteristics of different internal fixations were compared and analyzed...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28400664/enhanced-recovery-protocol-and-hidden-blood-loss-in-patients-undergoing-total-knee-arthroplasty
#14
Rohit Dhawan, Harshadkumar Rajgor, Rathan Yarlagadda, John John, Niall M Graham
BACKGROUND: Perioperative blood loss and postoperative pain following total knee arthroplasty prevent early mobilisation of patients. The Enhanced Recovery Protocol (ERP) followed for patients in our institute aims at reducing post operative pain, blood loss and length of stay. MATERIALS AND METHODS: 50 consecutive patients that underwent ERP following total knee arthroplasty with another group of 70 patients that underwent the same surgery without ERP were compared in terms of hidden blood loss and length of hospital stay...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28378211/intra-articular-versus-intravenous-tranexamic-acid-application-in-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#15
Bobin Mi, Guohui Liu, Wu Zhou, Huijuan Lv, Yi Liu, Kun Zha, Qipeng Wu, Jing Liu
BACKGROUND: The purpose of this meta-analysis was to compare the blood loss and complications of intra-articular (IA) with intravenous (IV) tranexamic acid (TXA) for total knee arthroplasty (TKA). METHODS: A comprehensive search of studies was conducted to identify related articles in Pubmed, Embase, Cochrane central Register of Controlled Trials, springerLink, OVID and the Research published from January 1980 to September 2016. All studies that compared IA TXA with IV TXA application on TKA were included...
July 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28358861/pcr-diagnosis-of-tick-borne-pathogens-in-maharashtra-state-india-indicates-fitness-cost-associated-with-carrier-infections-is-greater-for-crossbreed-than-native-cattle-breeds
#16
Sunil W Kolte, Stephen D Larcombe, Suresh G Jadhao, Swapnil P Magar, Ganesh Warthi, Nitin V Kurkure, Elizabeth J Glass, Brian R Shiels
Tick-borne pathogens (TBP) are responsible for significant economic losses to cattle production, globally. This is particularly true in countries like India where TBP constrain rearing of high yielding Bos taurus, as they show susceptibility to acute tick borne disease (TBD), most notably tropical theileriosis caused by Theileria annulata. This has led to a programme of cross breeding Bos taurus (Holstein-Friesian or Jersey) with native Bos indicus (numerous) breeds to generate cattle that are more resistant to disease...
2017: PloS One
https://www.readbyqxmd.com/read/28336258/a-comparison-of-combined-intravenous-and-topical-administration-of-tranexamic-acid-with-intravenous-tranexamic-acid-alone-for-blood-loss-reduction-after-total-hip-arthroplasty-a-meta-analysis
#17
REVIEW
Xiangcheng Liu, Jinglong Liu, Ganghe Sun
BACKGROUND: The optimal dose and protocol of tranexamic acid (TXA) for reducing blood loss in total hip arthroplasty (THA) is controversial. Intravenous TXA (IV-TXA) and combined IV-TXA with topical TXA are the two common protocol after THA. A meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of combined IV and topical TXA with IV-TXA alone in reducing blood loss after THA. METHODS: PubMed, Medline, Embase, Web of Science, the Cochrane Library, China Wanfang database and Google database were searched from the inception to February 2017 to identify RCTs that comparing combined IV and topical TXA with IV-TXA alone for patients prepared for primary THA...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28331889/unsupervised-labeling-of-glomerular-boundaries-using-gabor-filters-and-statistical-testing-in-renal-histology
#18
Brandon Ginley, John E Tomaszewski, Rabi Yacoub, Feng Chen, Pinaki Sarder
The glomerulus is the blood filtering unit of the kidney. Each human kidney contains [Formula: see text] glomeruli. Several renal conditions originate from structural damage to glomerular microcompartments, such as proteinuria, the excessive loss of blood proteins into urine. The gold standard for evaluating structural damage in renal pathology is histopathological and immunofluorescence examination of needle biopsies under a light microscope. This method is limited by qualitative or semiquantitative manual scoring approaches to the evaluation of glomerular structural features...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28330800/tourniquet-and-closed-suction-drains-in-total-knee-arthroplasty-no-beneficial-effects-on-bleeding-management-and-knee-function-at-a-higher-cost
#19
D Yin, J Delisle, A Banica, A Senay, P Ranger, G Y Laflamme, J Jun, J Fernandes
BACKGROUND: Blood loss is a major concern in total knee arthroplasty (TKA) along with postoperative knee function. The present study explores the impact of tourniquet (T) and closed-suction drains (D) on these parameters in TKA. MATERIALS AND METHODS: A prospective study was conducted on 111 patients admitted for TKA. Subjects were divided into three groups: 36 in group T+D+, 42 in T-D+ and 33 in T-D- (where T+: prolonged tourniquet use, T-: cementation-only tourniquet, D+: closed-suction drain use, and D-: no drain)...
June 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28319822/comparison-of-intravenous-versus-topical-tranexamic-acid-in-primary-total-hip-and-knee-arthroplasty-an-updated-meta-analysis
#20
REVIEW
Jinwei Xie, Qinsheng Hu, Qiang Huang, Jun Ma, Yiting Lei, Fuxing Pei
BACKGROUND: The appropriate route for administering tranexamic acid in primary total hip (THA) and knee arthroplasty (TKA) remains controversial. The purpose of this meta-analysis was to compare the efficacy and safety of topical or intravenous tranexamic acid. METHODS: PubMed, EMBASE, and the Cochrane Library databases were systematically searched for randomized controlled trials (RCTs) comparing topical and intravenous tranexamic acid following primary THA or TKA...
May 2017: Thrombosis Research
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