keyword
https://read.qxmd.com/read/38508375/-not-available
#1
JOURNAL ARTICLE
V Martin Gorgojo, S Burguet Girona, S Muñoz Donat
INTRODUCTION AND AIM: Minimally invasive surgery (MIS) of the spine prevents the collapse of osteoporotic vertebral fractures (OVF) with lower complication and bleeding rates than open surgery. However, the possibility of hidden blood loss (HBL) has been recently described, referring to the loss of blood diffused into tissues and lost through hemolysis. This study aimed to estimate the postoperative impact of HBL in patients undergoing MIS for OVF. MATERIALS AND METHODS: This was a retrospective study of a series of patients who had MIS for OVF...
March 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/38500931/type-b-aortic-dissection-masquerading-as-acute-pyelonephritis-think-beyond-measures
#2
Anas Ibraheem, Abdullah Abdullah, Kumari Priyam, Rebin Fakhruddin
Aortic dissection (AD) is a life-threatening medical emergency with a high mortality rate if misdiagnosed; therefore, an urgent and precise diagnosis is crucial for prompt treatment. This article presents a rare case report of AD with an atypical clinical presentation that led to delayed diagnosis and a complicated clinical course. Herein, we aim to contribute to the existing literature by providing insights into the varied presentations of AD and offering valuable lessons for clinicians faced with similar diagnostic scenarios...
February 2024: Curēus
https://read.qxmd.com/read/38429175/intramedullary-administration-of-tranexamic-acid-reduces-bleeding-in-proximal-femoral-nail-antirotation-surgery-for-intertrochanteric-fractures-in-elderly-individuals-a-randomized-controlled-trial
#3
JOURNAL ARTICLE
Xiang-Ping Luo, Jian Peng, Ling Zhou, Hao Liao, Xiao-Chun Jiang, Xiong Tang, Dun Tang, Chao Liu, Jian-Hui Liu
PURPOSE: Intertrochanteric fractures undergoing proximal femoral nail antirotation (PFNA) surgery are associated with significant hidden blood loss. This study aimed to explore whether intramedullary administration of tranexamic acid (TXA) can reduce bleeding in PFNA surgery for intertrochanteric fractures in elderly individuals. METHODS: A randomized controlled trial was conducted from January 2019 to December 2022. Patients aged over 60 years with intertrochanteric fractures who underwent intramedullary fixation surgery with PFNA were eligible for inclusion and grouped according to random numbers...
January 29, 2024: Chinese Journal of Traumatology
https://read.qxmd.com/read/38401515/supramolecular-assembly-of-micellar-aggregates-is-the-basis-of-low-endotoxin-recovery-ler-in-a-drug-formulation-that-can-be-resolved-by-a-whole-blood-assay
#4
JOURNAL ARTICLE
Andra B Schromm, Wilmar Correa, Nicolas Gisch, Frank Steiniger, Walter Richter, Guillermo Martinez-de-Tejada, Klaus Brandenburg, Friedrich von Wintzingerode
Lipopolysaccharide (LPS, endotoxin) is ubiquitous and represents a harmful contaminant of pharmaceutical compounds, recombinant biologicals and drug products. The pyrogen can induce severe immune responses and pathology in vitro and in vivo. Health authorities require strict control of endotoxin in parenteral drugs. However, for research and pre-clinical compound analysis, endotoxin testing is not a required quality control, which may cause potential drawbacks in the translational pipeline. Endotoxin testing is usually performed by the Limulus amebocyte lysate (LAL) assay, which is hampered by the so-called low endotoxin recovery (LER) effect when certain drug formulations are tested...
February 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38384164/risk-factors-of-hidden-blood-loss-in-unilateral-biportal-endoscopic-surgery-for-patients-with-lumbar-spinal-stenosis
#5
JOURNAL ARTICLE
Sheng Guo, Zhiyong Yu, Chenglong Wang, Mingqiang Zhong, Rui Wang, Yechang Hu, Chunling Wang, Sen Li
OBJECTIVE: Unilateral biportal endoscopic (UBE) surgery has recently been used as a minimally invasive procedure for the treatment of lumbar spinal stenosis and is associated with less perioperative blood loss. However, perioperative hidden blood loss (HBL) may be neglected during UBE. This study aimed to examine the volume of HBL and discuss the influential risk factors for HBL during unilateral biportal endoscopic surgery. METHODS: From January 2022 to August 2022, 51 patients underwent percutaneous unilateral biportal endoscopic surgery for lumbar spinal stenosis at the Department of Spinal Surgery of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University and were enrolled in this study...
February 21, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38375731/bibliometric-analysis-of-transforaminal-lumbar-interbody-fusion-in-lumbar-spine-surgery
#6
JOURNAL ARTICLE
Y-X Hu, R Yang, S-M Liu, H Wang
OBJECTIVE: The objective of this study is to conduct a bibliometric analysis to examine the current condition, areas of interest, and rising trends of transforaminal lumbar interbody fusion in lumbar spine surgery (TLIF), as well as its importance in associated research domains. MATERIALS AND METHODS: An extensive collection of academic papers on the use of TLIF was obtained from the Web of Science between January 1, 2000, and November 5, 2023. Then, using a variety of tools like HisCite, VOSviewer, CiteSpace, and the bibliometrix package, a bibliometric study was carried out...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38333318/hidden-blood-loss-in-three-different-endoscopic-spinal-procedures-for-lumbar-disc-herniation
#7
JOURNAL ARTICLE
Haoxiang Zhuang, Jiayi Li, Sijia Guo, Ning An, Zihan Fan, Haining Tan, Jisheng Lin, Nan Su, Yong Yang, Qi Fei, Hai Meng
PURPOSE: This study compared hidden blood loss (HBL) among three different endoscopic spinal procedures and investigated its risk factors. PATIENTS AND METHODS: This single-centre retrospective analysis collected data from consecutive hospitalized patients with single-segment lumbar disc herniation (LDH) undergoing unilateral biportal endoscopic discectomy (UBE), percutaneous endoscopic transforaminal discectomy (PETD), or percutaneous endoscopic interlaminar discectomy (PEID) from December 2020 to October 2022...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38313391/unveiling-the-silent-link-normal-tension-glaucoma-s-enigmatic-bond-with-cardiac-blood-flow
#8
REVIEW
Prasanna Venkatesh Ramesh, Arvind Kumar Morya, Ajanya K Aradhya, Pavithra Pannerselvam, Sai Thaejesvi Gopalakrishnan, Shruthy Vaishali Ramesh, Aji Kunnath Devadas, Navaneeth Krishna
This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma (NTG), a condition that continues to baffle clinicians and researchers alike. NTG, characterized by optic nerve damage and visual field loss despite normal intraocular pressure, has long puzzled clinicians. One emerging perspective suggests that alterations in ocular blood flow, particularly within the optic nerve head, may play a pivotal role in its pathogenesis. While NTG shares commonalities with its high-tension counterpart, its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of exploration...
January 26, 2024: World Journal of Cardiology
https://read.qxmd.com/read/38290563/the-hidden-risks-of-perioperative-transfusions-in-traumatic-lower-extremity-free-flap-reconstruction
#9
JOURNAL ARTICLE
Kylie Swiekatowski, Arvind Manisundaram, Delani Woods, Jackson C Green, Mohin A Bhadkamkar, Yuewei Wu-Fienberg
BACKGROUND: Blood transfusions have been associated with surgical complications; however, these studies are not specific to lower extremity (LE) reconstruction. We evaluated the effect of perioperative packed red blood cell (PRBC) transfusions on LE free flap outcomes in trauma patients. METHODS: Patients undergoing LE free flap reconstruction following acute injuries from 2016-2021 were retrospectively analyzed. The perioperative period for transfusions was defined as ±3 days from the procedure...
January 30, 2024: Journal of Reconstructive Microsurgery
https://read.qxmd.com/read/38280078/recombinant-antibody-fragments-for-immunotherapy-of-parkinson-s-disease
#10
REVIEW
Karen Manoutcharian, Goar Gevorkian
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Multiple genetic and environmental factors leading to progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SN) and consequent depletion of dopamine were described. Current clinical approaches, such as dopamine replacement or deep brain stimulation using surgically implanted probes, provide symptomatic relief but cannot modify disease progression. Therefore, disease-modifying therapeutic tools are urgently needed...
January 27, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/38230362/cricothyrotomy-in-acute-upper-gastrointestinal-bleed-a-difficult-airway-simulation-case-for-anesthesiology-residents
#11
JOURNAL ARTICLE
Corinna J Yu, Frank Rigueiro, Kevin Backfish-White, Johnny Cartwright, Christopher Moore, Sally A Mitchell, Tanna Boyer
INTRODUCTION: Patients with acute upper gastrointestinal bleeding may have challenging airways. This simulation teaches anesthesiology residents the skill of cricothyrotomy as a surgical last resort while managing acute bleeding in the airway. METHODS: The simulation involved a 55-year-old patient with history of alcohol abuse admitted to the ICU with hematemesis and acute blood loss for esophagogastroduodenoscopy in the ICU setting. The mannequin had tubing in the posterior oropharynx connected to a pressurized bag of simulated blood hidden from view...
2024: MedEdPORTAL Publications
https://read.qxmd.com/read/38228759/hidden-blood-loss-and-bleeding-characteristics-in-children-with-congenital-scoliosis-undergoing-spinal-osteotomies
#12
JOURNAL ARTICLE
Arimatias Raitio, Susanna Heiskanen, Venla Soini, Linda Helenius, Johanna Syvänen, Ilkka Helenius
PURPOSE: Spinal osteotomies are often essential in the treatment of congenital scoliosis. Risk factors for bleeding in these patients needing extracavitatory approaches, especially hidden blood loss, are sparsely investigated. We aimed to investigate the bleeding characteristics and hidden blood loss in paediatric patients undergoing spinal osteotomies for congenital scoliosis. METHODS: A retrospective analysis identified all patients with congenital scoliosis were retrospectively identified from the prospectively collected spine register from 2010 to 2022...
January 17, 2024: International Orthopaedics
https://read.qxmd.com/read/38225834/-evaluation-of-early-effectiveness-of-local-infiltration-anesthesia-with-compound-betamethasone-in-total-knee-arthroplasty
#13
JOURNAL ARTICLE
Yuhang Zheng, Yang Li, Hua Tian
OBJECTIVE: To evaluate the early effectiveness of local infiltration anesthesia (LIA) with compound betamethasone in total knee arthroplasty (TKA). METHODS: The clinical data of 102 patients with knee osteoarthritis who were treated by TKA and met the selection criteria between May 2022 and March 2023 were retrospectively analyzed. They were divided into control group and study group according to whether LIA preparation was added with compound betamethasone, with 51 cases in each group...
January 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38223134/risk-factors-analysis-and-nomogram-model-establishment-of-hidden-blood-loss-in-overweight-and-obese-elderly-patients-after-total-hip-arthroplasty
#14
JOURNAL ARTICLE
Yu Sun, Haixiang Miao, Han Gong, Yaxin Zhang, Weishi Hong
BACKGROUND: Total hip arthroplasty (THA) has become the first-choice treatment for elderly patients with end-stage hip disease. The high amount of hidden blood loss (HBL) in overweight and obese patients after THA not only affects rapid recovery, but also results in a greater economic burden. We aimed to identify risk factors that contribute to elevated HBL in overweight and obese patients after THA by retrospective analysis, and establish a nomogram prediction model for massive HBL in overweight and obese patients after THA...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38129119/a-comparison-of-hidden-blood-loss-between-multilevel-posterior-lumbar-interbody-fusion-and-lateral-lumbar-interbody-fusion-in-adult-spinal-deformity-patients
#15
JOURNAL ARTICLE
Hayato Kinoshita, Eiji Abe, Takashi Kobayashi, Michio Hongo, Yuji Kasukawa, Kazuma Kikuchi, Daisuke Kudo, Ryota Kimura, Naohisa Miyakoshi
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: This study aimed to compare transfusion and blood loss volumes, particularly hidden blood loss volume, in adult spinal deformity patients undergoing lateral lumbar interbody fusion (LLIF) and posterior lumbar interbody fusion (PLIF). Corrective surgery for adults with spinal deformity patients can be performed via the traditional posterior approach (PLIF) or minimally invasive lateral approach (LLIF). LLIF is associated with longer or comparable operation times and lower intraoperative blood loss...
December 21, 2023: Global Spine Journal
https://read.qxmd.com/read/38126886/whole-course-intraperitoneal-robot-assisted-choledochal-cyst-excision-with-a-hidden-incision-in-children-under-1-year-old
#16
JOURNAL ARTICLE
Yingquan Zhuo, Xianwu Yang, Jun Du, Hua Jiang, Xu Sun, Guangtang Chen, Kunfeng He, Wengqi Zhang, Jun Liao, Huajian Gu
Background: Whole-course intraperitoneal robot-assisted choledochal cyst resection in children under 1 year of age is controversial due to its technical challenges. Current Pfannenstiel incision is widely used in adults for its cosmetic effects but is rarely used in children. Materials and Methods: We conducted a prospective, single-center study to assess the feasibility, safety, and cosmesis of whole-course intraperitoneal robot-assisted choledochal cyst resection with Pfannenstiel incision in children under 1 year of age...
December 21, 2023: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38108164/controlled-hypotension-technology-can-improve-patient-recovery-in-the-early-postoperative-period-after-total-knee-arthroplasty-a-prospective-randomized-controlled-clinical-study
#17
RANDOMIZED CONTROLLED TRIAL
Xinglong Li, Jiawei Liu, Hongliang Wang, Ya Ding
OBJECTIVES: The study aimed to analyze the application of controlled hypotension and tourniquets in total knee arthroplasty (TKA) to evaluate their early postoperative period effects in TKA. PATIENTS AND METHODS: A total of 183 patients (43 males, 140 females; mean age: 67.8±6.4 years; range, 50 to 84 years) with knee osteoarthritis who needed TKA were recruited for this prospective, randomized controlled clinical study between August 2022 and May 2023. The study included a tourniquet group (group T, 94 patients) and a controlled hypotension group (group H, 89 patients)...
January 1, 2024: Joint diseases and related surgery
https://read.qxmd.com/read/38101535/hidden-blood-loss-in-minimally-invasive-surgery-for-osteoporotic-vertebral-fractures
#18
JOURNAL ARTICLE
Victor Martin-Gorgojo, Sara Burguet Girona, Sonia Muñoz Donat
INTRODUCTION AND AIM: Minimally invasive surgery (MIS) of the spine prevents the collapse of osteoporotic vertebral fractures (OVF) with lower complication and bleeding rates than open surgery. However, the possibility of hidden blood loss (HBL) has been recently described, referring to the loss of blood diffused into tissues and lost through hemolysis. This study aimed to estimate the postoperative impact of HBL in patients undergoing MIS for OVF. MATERIALS AND METHODS: This was a retrospective study of a series of patients who had MIS for OVF...
December 13, 2023: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/38062270/a-comparative-study-on-hemostasis-effect-of-different-application-methods-and-time-of-tranexamic-acid-in-total-hip-arthroplasty
#19
JOURNAL ARTICLE
Wenjun Zhou, Hui Lv, Huan Zhang, Yong Ding, Jiawei Zhou, Huan Tong, Junkai Cui
OBJECTIVES: To analyze the hemostatic effect of different application methods and time of tranexamic acid (TXA) on primary unilateral total hip arthroplasty. METHODS: A total of 126 patients with primary unilateral total hip replacement admitted between January 2019 and January 2021 were recruited. The patients were divided into three groups (42 people in each group) by random number table method. In group I, 2.0 g TXA was perfused locally into the hip joint cavity through the drainage tube for 2 h...
December 7, 2023: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38058509/blood-loss-in-primary-unilateral-total-knee-arthroplasty-with-limited-tourniquet-application-a-randomized-controlled-trial
#20
JOURNAL ARTICLE
Doried Diri, Hakam Alasaad, Sedra Abou Ali Mhana, Hussain Muhammed, Jaber Ibrahim
BACKGROUND: Tourniquet application in total knee arthroplasty (TKA) has many benefits and may have a role in the incidence of perioperative complications. Our aims were to examine the safety of applying a tourniquet for a limited amount of time during primary unilateral TKA (specifically, during cementation and final component fixation only) and to compare perioperative complications between the limited-application group and the full-application group. METHODS: We conducted a randomized controlled study of 62 patients undergoing primary unilateral TKA...
2023: JB & JS Open Access
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