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https://www.readbyqxmd.com/read/29320427/peptide-mediated-liposome-fusion-the-effect-of-anchor-positioning
#1
Niek S A Crone, Dirk Minnee, Alexander Kros, Aimee L Boyle
A minimal model system for membrane fusion, comprising two complementary peptides dubbed "E" and "K" joined to a cholesterol anchor via a polyethyleneglycol spacer, has previously been developed in our group. This system promotes the fusion of large unilamellar vesicles and facilitates liposome-cell fusion both in vitro and in vivo. Whilst several aspects of the system have previously been investigated to provide an insight as to how fusion is facilitated, anchor positioning has not yet been considered. In this study, the effects of placing the anchor at either the N-terminus or in the center of the peptide are investigated using a combination of circular dichroism spectroscopy, dynamic light scattering, and fluorescence assays...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29302173/in-women-s-eyes-key-barriers-to-women-s-access-to-hiv-treatment-and-a-rights-based-approach-to-their-sustained-well-being
#2
Luisa Orza, Emily Bass, Emma Bell, E Tyler Crone, Nazneen Damji, Sophie Dilmitis, Liz Tremlett, Nasra Aidarus, Jacqui Stevenson, Souhaila Bensaid, Calorine Kenkem, Gracia Violeta Ross, Elena Kudravtseva, Alice Welbourn
There is rightly a huge global effort to enable women living with HIV to have long productive lives, through treatment access. However, many women living with HIV experience violence against women (VAW), in both domestic and health care settings. The ways in which VAW might prevent treatment access and adherence for women has not to date been reviewed coherently at the global level, from women's own perspectives. Meanwhile, funding for global health care, including HIV treatment, is shrinking. To optimize women's health and know how best to optimize facilitators and minimize barriers to access and adherence, especially in this shrinking funding context, we need to understand more about these issues from women's own perspectives...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29280185/neural-perspectives-on-cognitive-control-development-during-childhood-and-adolescence-should-take-into-account-how-the-obesity-affects-brain-development
#3
Irene Esteban-Cornejo, Francisco B Ortega, Andrés Catena
Cognitive control comprises working memory, inhibition, cognitive flexibility and error monitoring and is closely tied to the development of the prefrontal cortex. The fact that the prefrontal cortex is important for cognitive control has been consistently shown among adults (1). Crone and Steinbeis explored new ways of categorising developmental progressions in cognitive control during childhood and adolescence (1). They revealed that the functional development of the dorsolateral prefrontal cortex supports the development of deliberative processes, whereas the medial prefrontal cortex supports the development of internalised decisions (1)...
December 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29277104/the-importance-of-the-hawthorne-effect-on-psychological-outcomes-unveiled-in-a-randomized-controlled-trial-of-diabetes-technology
#4
Mary B Abraham, Jennifer A Nicholas, Michael Crone, Trang T Ly, Elizabeth A Davis, Timothy W Jones
No abstract text is available yet for this article.
December 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29259158/increased-striatal-activity-in-adolescence-benefits-learning
#5
S Peters, E A Crone
Adolescence is associated with enhanced striatal activity in response to rewards. This has been linked to increased risk-taking behavior and negative health outcomes. However, striatal activity is also important for learning, yet it is unknown whether heightened striatal responses in adolescence also benefit cognitive learning performance. In this longitudinal fMRI study (736 scans spanning 5 years in participants ages 8-29), we investigate whether adolescents show enhanced striatal activity during feedback learning, and whether this enhanced activity is associated with better learning performance...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29247963/ecog-high-gamma-modulation-versus-electrical-stimulation-for-presurgical-language-mapping
#6
Ravindra Arya, Paul S Horn, Nathan E Crone
OBJECTIVE: This meta-analysis compared diagnostic validity of electrocorticographic (ECoG) high-γ modulation (HGM) with electrical stimulation mapping (ESM) for presurgical language localization. METHODS: From a structured literature search, studies with electrode level data comparing ECoG HGM and ESM for language localization were included in the meta-analysis. Outcomes included global measures of diagnostic validity: area under the summary receiver operating characteristic (SROC) curve (AUC), and diagnostic odds ratio (DOR); as well as pooled estimates of sensitivity and specificity...
December 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29227494/the-crucial-role-of-a-spacer-material-on-the-efficiency-of-charge-transfer-processes-in-organic-donor-acceptor-junction-solar-cells
#7
Reed Nieman, Hsinhan Tsai, Wanyi Nie, Adelia J A Aquino, Aditya D Mohite, Sergei Tretiak, Hao Li, Hans Lischka
Organic photovoltaic donor-acceptor junction devices composed of π-conjugated polymer electron donors (D) and fullerene electron acceptors (A) show greatly increased performance when a spacer material is inserted between the two layers (W. Y. Nie, G. Gupta, B. K. Crone, F. L. Liu, D. L. Smith, P. P. Ruden, C. Y. Kuo, H. Tsai, H. L. Wang, H. Li, S. Tretiak and A. D. Mohite, Adv. Sci., 2015, 2, 1500024.). For instance, experimental results reveal significant improvement of photocurrent when a terthiophene oligomer derivative is inserted in between π-conjugated poly(3-hexylthiophene-2,5-diyl) (P3HT) donor and C60 acceptor...
December 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29197726/the-neural-signature-of-self-concept-development-in-adolescence-the-role-of-domain-and-valence-distinctions
#8
R van der Cruijsen, S Peters, L P E van der Aar, E A Crone
Neuroimaging studies in adults showed that cortical midline regions including medial prefrontal cortex (mPFC) and posterior parietal cortex (PPC) are important in self-evaluations. The goals of this study were to investigate the contribution of these regions to self-evaluations in late childhood, adolescence, and early adulthood, and to examine whether these differed per domain (academic, physical and prosocial) and valence (positive versus negative). Also, we tested whether this activation changes across adolescence...
November 22, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29174388/smokers-identity-and-quit-advice-in-general-practice-general-practitioners-need-to-focus-more-on-female-smokers
#9
Eline Meijer, Marjolein E A Verbiest, Niels H Chavannes, Ad A Kaptein, Willem J J Assendelft, Margreet Scharloo, Mathilde R Crone
OBJECTIVE: We examined smoker and non-smoker self-identities among smokers visiting their general practitioner (GP) for other reasons than smoking cessation counselling. We determined whether identity impacted on patients' appreciation of GP-initiated conversations about smoking and quit advice, and subsequent quit attempts, and examined the role of gender. METHODS: Secondary analyses of a cluster-randomised controlled trial in which baseline and 12-month follow-up data were collected among 527 daily (n=450) and non-daily smokers (n=77)...
November 17, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29164716/mechanism-matters-the-cause-of-fluctuations-in-boom-bust-populations-governs-optimal-habitat-restoration-strategy
#10
Gina K Himes Boor, Cheryl B Schultz, Elizabeth E Crone, William F Morris
Many populations exhibit boom-bust dynamics in which abundance fluctuates dramatically over time. Past research has focused on identifying whether the cause of fluctuations is primarily exogenous, e.g., environmental stochasticity coupled with weak density dependence, or endogenous, e.g., over-compensatory density dependence. Far fewer studies have addressed whether the mechanism responsible for boom-bust dynamics matters with respect to at-risk species management. Here, we ask whether the best strategy for restoring habitat across a landscape differs under exogenously versus endogenously driven boom-bust dynamics...
November 21, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29122043/physical-activity-promotion-by-health-practitioners-a-distance-learning-training-component-to-improve-knowledge-and-counseling
#11
Alex A Florindo, Douglas R Andrade, Paulo H Guerra, Jorge Mota, Diane Crone, Ana C C N Mafra, Mario M Bracco
Aim To report an evaluation of health professionals' participation in a distance-learning physical activity training course developed in a low socio-economic region of São Paulo city, Brazil. BACKGROUND: In countries with public universal health systems, physical activity promotion in primary health care settings can reap results, particularly given that such interventions have the potential to reach a large percentage of the population. However, few studies proposed physical activity training for health professionals in low- and middle-income countries...
November 10, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29045836/arc-requires-psd95-for-assembly-into-postsynaptic-complexes-involved-with-neural-dysfunction-and-intelligence
#12
Esperanza Fernández, Mark O Collins, René A W Frank, Fei Zhu, Maksym V Kopanitsa, Jess Nithianantharajah, Sarah A Lemprière, David Fricker, Kathryn A Elsegood, Catherine L McLaughlin, Mike D R Croning, Colin Mclean, J Douglas Armstrong, W David Hill, Ian J Deary, Giulia Cencelli, Claudia Bagni, Menachem Fromer, Shaun M Purcell, Andrew J Pocklington, Jyoti S Choudhary, Noboru H Komiyama, Seth G N Grant
Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition. We applied an integrated proteomic and genetic strategy by targeting a tandem affinity purification (TAP) tag and Venus fluorescent protein into the endogenous Arc gene in mice. This allowed biochemical and proteomic characterization of native complexes in wild-type and knockout mice. We identified many Arc-interacting proteins, of which PSD95 was the most abundant...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29029719/erratum-to-not-just-guess-work-tips-for-observation-brainstorming-and-prototyping-vasc-interv-radiol-20-2017-94-100
#13
Ryan Crone
No abstract text is available yet for this article.
September 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28960629/a-multisample-study-of-longitudinal-changes-in-brain-network-architecture-in-4-13-year-old-children
#14
Lara M Wierenga, Martijn P van den Heuvel, Bob Oranje, Jay N Giedd, Sarah Durston, Jiska S Peper, Timothy T Brown, Eveline A Crone
Recent advances in human neuroimaging research have revealed that white-matter connectivity can be described in terms of an integrated network, which is the basis of the human connectome. However, the developmental changes of this connectome in childhood are not well understood. This study made use of two independent longitudinal diffusion-weighted imaging data sets to characterize developmental changes in the connectome by estimating age-related changes in fractional anisotropy (FA) for reconstructed fibers (edges) between 68 cortical regions...
September 28, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28898569/altered-task-related-modulation-of-long-range-connectivity-in-children-with-autism
#15
Ajay S Pillai, Danielle McAuliffe, Balaji M Lakshmanan, Stewart H Mostofsky, Nathan E Crone, Joshua B Ewen
Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task...
September 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28875060/assessment-of-the-drug-drug-interaction-potential-between-theacrine-and-caffeine-in-humans
#16
Hui He, Dejian Ma, Laura Brooks Crone, Matthew Butawan, Bernd Meibohm, Richard J Bloomer, Charles R Yates
Objective: Theacrine, a methylurate class purine alkaloid, triggers diverse pharmacologic responses, including psychostimulatory activity by modulation of adenosinergic and dopaminergic pathways. In a double-blind, placebo-controlled study, theacrine increased energy, concentration, and mood, while reducing fatigue. Because caffeine, a methylxanthine purine alkaloid, is frequently coadministered with theacrine, we sought to determine if a pharmacokinetic and/or pharmacodynamic interaction existed between theacrine and caffeine...
September 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28819107/medial-prefrontal-cortical-thinning-mediates-shifts-in-other-regarding-preferences-during-adolescence
#17
Sunhae Sul, Berna Güroğlu, Eveline A Crone, Luke J Chang
Adolescence is a time of significant cortical changes in the 'social brain', a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801920/restoration-of-thalamo-cortical-connectivity-after-brain-injury-recovery-of-consciousness-complex-behavior-or-passage-of-time
#18
Julia S Crone, Branden J Bio, Paul M Vespa, Evan S Lutkenhoff, Martin M Monti
In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to the return of complex cognitive function in general or simply the temporal evolution of post-injury pathophysiological events. To test whether the restoration of thalamo-cortical connectivity is specific to consciousness, 20 moderate-to-severe brain injury patients (from a recruited sample of 42) underwent resting-state functional magnetic resonance imaging within a week after injury and again six months later...
August 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28800634/utilizing-the-r-v-marcus-g-langseth-s-streamer-to-measure-the-acoustic-radiation-of-its-seismic-source-in-the-shallow-waters-of-new-jersey-s-continental-shelf
#19
Timothy J Crone, Maya Tolstoy, James C Gibson, Gregory Mountain
Shallow water marine seismic surveys are necessary to understand a range of Earth processes in coastal environments, including those that represent major hazards to society such as earthquakes, tsunamis, and sea-level rise. Predicting the acoustic radiation of seismic sources in shallow water, which is required for compliance with regulations designed to limit impacts on protected marine species, is a significant challenge in this environment because of variable reflectivity due to local geology, and the susceptibility of relatively small bathymetric features to focus or shadow acoustic energy...
2017: PloS One
https://www.readbyqxmd.com/read/28774583/language-and-motor-function-thresholds-during-pediatric-extra-operative-electrical-cortical-stimulation-brain-mapping
#20
Alonso Zea Vera, Gewalin Aungaroon, Paul S Horn, Anna W Byars, Hansel M Greiner, Jeffrey R Tenney, Todd M Arthur, Nathan E Crone, Katherine D Holland, Francesco T Mangano, Ravindra Arya
OBJECTIVE: To examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS). METHODS: ECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses. RESULTS: In 122 patients (age 11.9±5.4years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3...
October 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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