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Lara M Wierenga, Marieke G N Bos, Elisabeth Schreuders, Ferdi Vd Kamp, Jiska S Peper, Christian K Tamnes, Eveline A Crone
The onset of adolescence in humans is marked by hormonal changes that give rise to secondary sexual characteristics, noted as puberty. It has, however, proven challenging to unravel to what extent pubertal changes may have organizing effects on the brain beyond chronological age, as reported in animal studies. The present longitudinal study aimed to characterize the unique effects of age and puberty on subcortical brain volumes and included three waves of data collection at two-year intervals and 680 T1-weighted MRI scans of 271 participants (54% females) aged between 8 and 29 years old...
March 8, 2018: Psychoneuroendocrinology
Elisabeth Schreuders, Barbara R Braams, Neeltje E Blankenstein, Jiska S Peper, Berna Güroğlu, Eveline A Crone
It was examined how ventral striatum responses to rewards develop across adolescence and early adulthood and how individual differences in state- and trait-level reward sensitivity are related to these changes. Participants (aged 8-29 years) were tested across three waves separated by 2 years (693 functional MRI scans) in an accelerated longitudinal design. The results confirmed an adolescent peak in reward-related ventral striatum, specifically nucleus accumbens, activity. In early to mid-adolescence, increases in reward activation were related to trait-level reward drive...
March 13, 2018: Child Development
Stacie Craft DeFreitas, Travis Crone, Martha DeLeon, Anna Ajayi
Mental health stigma occurs when people have negative thoughts and beliefs of those with mental health illnesses or mental health treatment. Mental health stigma is related to an assortment of negative outcomes including discrimination in housing and employment, reduced usage of mental health services, and poor mental health outcomes. These implications may be particularly salient for ethnic minorities such as African Americans and Latinos who already suffer from other types of discrimination. This study examines perceived and personal mental health stigma in African American and Latino college students from a nontraditional university to help elucidate factors related to the development of mental health stigma...
2018: Frontiers in Public Health
Michelle Achterberg, Anna C K van Duijvenvoorde, Mara van der Meulen, Marian J Bakermans-Kranenburg, Eveline A Crone
Middle childhood marks an important phase for developing and maintaining social relations. At the same time, this phase is marked by a gap in our knowledge of the genetic and environmental influences on brain responses to social feedback and their relation to behavioral aggression. In a large developmental twin sample (509 7- to 9-year-olds), the heritability and neural underpinnings of behavioral aggression following social evaluation were investigated, using the Social Network Aggression Task (SNAT). Participants viewed pictures of peers that gave positive, neutral, or negative feedback to the participant's profile...
March 12, 2018: Human Brain Mapping
Andrik I Becht, Marieke G N Bos, Stefanie A Nelemans, Sabine Peters, Wilma A M Vollebergh, Susan J T Branje, Wim H J Meeus, Eveline A Crone
This multimethod multisample longitudinal study examined how neurological substrates associated with goal directedness and information seeking are related to adolescents' identity. Self-reported data on goal-directedness were collected across three biannual waves in Study 1. Identity was measured one wave later. Study 1 design and measurements were repeated in Study 2 and extended with structural brain data (nucleus accumbens [NAcc] and prefrontal cortex gray matter volume [PFC]), collected across three biannual waves...
March 8, 2018: Child Development
Eveline A Crone, Elly A Konijn
The current generation of adolescents grows up in a media-saturated world. However, it is unclear how media influences the maturational trajectories of brain regions involved in social interactions. Here we review the neural development in adolescence and show how neuroscience can provide a deeper understanding of developmental sensitivities related to adolescents' media use. We argue that adolescents are highly sensitive to acceptance and rejection through social media, and that their heightened emotional sensitivity and protracted development of reflective processing and cognitive control may make them specifically reactive to emotion-arousing media...
February 21, 2018: Nature Communications
Diane M Crone, Rachel C Sumner, Colin M Baker, Elizabeth A Loughren, Samantha Hughes, David V B James
Background: Arts for health interventions are an accepted option for medical management of mental wellbeing in health care. Updated findings are presented from a prospective longitudinal follow-up (observational) design study of an arts on referral programme in UK general practice, over a 7-year period (2009-2016). Methods: Primary care process and mental wellbeing outcomes were investigated, including progress through the intervention, changes in mental wellbeing, and factors associated with those outcomes...
February 16, 2018: European Journal of Public Health
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016). Its manifestation is complex and as such, the disorder is recognized as influencing adherence to prescribed medication, service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psycho-educational group therapy on a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
Ravindra Arya, J Adam Wilson, Hisako Fujiwara, Jennifer Vannest, Anna W Byars, Leonid Rozhkov, James L Leach, Hansel M Greiner, Jason Buroker, Craig Scholle, Paul S Horn, Nathan E Crone, Douglas F Rose, Francesco T Mangano, Katherine D Holland
OBJECTIVE: This prospective study compared the topography of high-gamma modulation (HGM) during a story-listening task requiring negligible patient cooperation, with the conventional electrical stimulation mapping (ESM) using a picture-naming task, for presurgical language localization in pediatric drug-resistant epilepsy. METHODS: Patients undergoing extraoperative monitoring with subdural electrodes were included. Electrocorticographic signals were recorded during quiet baseline and a story-listening task...
February 20, 2018: Epilepsia
Sarah A Kelley, Shenandoah Robinson, Nathan E Crone, Bruno P Soares
INTRODUCTION: Bottom-of-sulcus focal cortical dysplasias are an under recognized, surgically treatable cause of focal epilepsy. Resection can dramatically reduce the seizure burden for children with refractory epilepsy, or eliminate seizures altogether. MATERIAL AND METHODS: We report the case and present the results of multimodality evaluation of a 15-year-old young man who presented with long-standing partial epilepsy affecting his right leg, which over the years became refractory to therapy...
February 14, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Melissa M Norberg, Cassandra Crone, Cathy Kwok, Jessica R Grisham
Background and aims Most individuals with hoarding disorder (HD) are prone to excessively acquiring new possessions. Understanding the factors that contribute to this collecting behavior will allow us to develop better treatment approaches for HD. The aim of this study was to test our assumption that an anxious attachment style is associated with a tendency to anthropomorphize comforting objects and an inability to tolerate distress, which in turn leads to excessive acquisition. Methods A total of 361 participants with subclinical to clinical acquisition problems (77...
February 15, 2018: Journal of Behavioral Addictions
John Guinane, Rosie Crone
BACKGROUND: Faecal incontinence significantly affects a patient's quality of life, and limited research has been conducted into effective interventions that are specific to residential aged care. Australian and New Zealand prevalence data indicate a general faecal incontinence rate of 12-13% in older adults and up to 50% in residential aged care. OBJECTIVE: The objective of this article is to describe the suggested initial investigation and management of faecal incontinence in older adults residing in residential aged care...
January 2018: Aust J Gen Pract
Sarah Cashman, Xin Ma, Janet Mosley, Jay Garland, Brian Crone, Xiaobo Xue
This study calculated the energy and greenhouse gas life cycle and cost profiles of transitional aerobic membrane bioreactors (AeMBR) and anaerobic membrane bioreactors (AnMBR). Membrane bioreactors (MBR) represent a promising technology for decentralized wastewater treatment and can produce recycled water to displace potable water. Energy recovery is possible with methane generated from AnMBRs. Scenarios for these technologies were investigated for different scale systems serving various population densities under a number of climate conditions with multiple methane recovery options...
January 12, 2018: Bioresource Technology
N E Blankenstein, E Schreuders, J S Peper, E A Crone, A C K van Duijvenvoorde
Although many neuroimaging studies have investigated adolescent risk taking, few studies have dissociated between decision-making under risk (known probabilities) and ambiguity (unknown probabilities). Furthermore, which brain regions are sensitive to individual differences in task-related and self-reported risk taking remains elusive. We presented 198 adolescents (11-24 years, an age-range in which individual differences in risk taking are prominent) with an fMRI paradigm that separated decision-making (choosing to gamble or not) and reward outcome processing (gains, no gains) under risky and ambiguous conditions, and related this to task-related and self-reported risk taking...
February 2, 2018: NeuroImage
Brigitte Tenhumberg, Elizabeth E Crone, Satu Ramula, Andrew J Tyre
Temperature and precipitation determine the conditions where plant species can occur. Despite their significance, to date, surprisingly few demographic field studies have considered the effects of abiotic drivers. This is problematic because anticipating the effect of global climate change on plant population viability requires understanding how weather variables affect population dynamics. One possible reason for omitting the effect of weather variables in demographic studies is the difficulty in detecting tight associations between vital rates and environmental drivers...
January 30, 2018: Ecology
Kiyohide Usami, Griffin W Milsap, Anna Korzeniewska, Maxwell J Collard, Yujing Wang, Ronald P Lesser, William S Anderson, Nathan E Crone
Any given area in human cortex may receive input from multiple, functionally heterogeneous areas, potentially representing different processing threads. Alpha (8-13 Hz) and beta oscillations (13-20 Hz) have been hypothesized by other investigators to gate local cortical processing, but their influence on cortical responses to input from other cortical areas is unknown. To study this, we measured the effect of local oscillatory power and phase on cortical responses elicited by single-pulse electrical stimulation (SPES) at distant cortical sites, in awake human subjects implanted with intracranial electrodes for epilepsy surgery...
January 24, 2018: Cerebral Cortex
Damien L Crone, Stefan Bode, Carsten Murawski, Simon M Laham
A major obstacle for the design of rigorous, reproducible studies in moral psychology is the lack of suitable stimulus sets. Here, we present the Socio-Moral Image Database (SMID), the largest standardized moral stimulus set assembled to date, containing 2,941 freely available photographic images, representing a wide range of morally (and affectively) positive, negative and neutral content. The SMID was validated with over 820,525 individual judgments from 2,716 participants, with normative ratings currently available for all images on affective valence and arousal, moral wrongness, and relevance to each of the five moral values posited by Moral Foundations Theory...
2018: PloS One
Niek S A Crone, Dirk Minnee, Alexander Kros, Aimee L Boyle
A minimal model system for membrane fusion, comprising two complementary peptides dubbed "E" and "K" joined to a cholesterol anchor via a polyethyleneglycol spacer, has previously been developed in our group. This system promotes the fusion of large unilamellar vesicles and facilitates liposome-cell fusion both in vitro and in vivo. Whilst several aspects of the system have previously been investigated to provide an insight as to how fusion is facilitated, anchor positioning has not yet been considered. In this study, the effects of placing the anchor at either the N-terminus or in the center of the peptide are investigated using a combination of circular dichroism spectroscopy, dynamic light scattering, and fluorescence assays...
January 10, 2018: International Journal of Molecular Sciences
Luisa Orza, Emily Bass, Emma Bell, E Tyler Crone, Nazneen Damji, Sophie Dilmitis, Liz Tremlett, Nasra Aidarus, Jacqui Stevenson, Souhaila Bensaid, Calorine Kenkem, Gracia Violeta Ross, Elena Kudravtseva, Alice Welbourn
There is rightly a huge global effort to enable women living with HIV to have long productive lives, through treatment access. However, many women living with HIV experience violence against women (VAW), in both domestic and health care settings. The ways in which VAW might prevent treatment access and adherence for women has not to date been reviewed coherently at the global level, from women's own perspectives. Meanwhile, funding for global health care, including HIV treatment, is shrinking. To optimize women's health and know how best to optimize facilitators and minimize barriers to access and adherence, especially in this shrinking funding context, we need to understand more about these issues from women's own perspectives...
December 2017: Health and Human Rights
Irene Esteban-Cornejo, Francisco B Ortega, Andrés Catena
Cognitive control comprises working memory, inhibition, cognitive flexibility and error monitoring and is closely tied to the development of the prefrontal cortex. The fact that the prefrontal cortex is important for cognitive control has been consistently shown among adults (1). Crone and Steinbeis explored new ways of categorising developmental progressions in cognitive control during childhood and adolescence (1). They revealed that the functional development of the dorsolateral prefrontal cortex supports the development of deliberative processes, whereas the medial prefrontal cortex supports the development of internalised decisions (1)...
December 27, 2017: Acta Paediatrica
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