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https://www.readbyqxmd.com/read/28898569/altered-task-related-modulation-of-long-range-connectivity-in-children-with-autism
#1
Ajay S Pillai, Danielle McAuliffe, Balaji M Lakshmanan, Stewart H Mostofsky, Nathan E Crone, Joshua B Ewen
Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task...
September 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28875060/assessment-of-the-drug-drug-interaction-potential-between-theacrine-and-caffeine-in-humans
#2
Hui He, Dejian Ma, Laura Brooks Crone, Matthew Butawan, Bernd Meibohm, Richard J Bloomer, Charles R Yates
Objective: Theacrine, a methylurate class purine alkaloid, triggers diverse pharmacologic responses, including psychostimulatory activity by modulation of adenosinergic and dopaminergic pathways. In a double-blind, placebo-controlled study, theacrine increased energy, concentration, and mood, while reducing fatigue. Because caffeine, a methylxanthine purine alkaloid, is frequently coadministered with theacrine, we sought to determine if a pharmacokinetic and/or pharmacodynamic interaction existed between theacrine and caffeine...
September 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28819107/medial-prefrontal-cortical-thinning-mediates-shifts-in-other-regarding-preferences-during-adolescence
#3
Sunhae Sul, Berna Güroğlu, Eveline A Crone, Luke J Chang
Adolescence is a time of significant cortical changes in the 'social brain', a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801920/restoration-of-thalamo-cortical-connectivity-after-brain-injury-recovery-of-consciousness-complex-behavior-or-passage-of-time
#4
Julia S Crone, Branden J Bio, Paul M Vespa, Evan S Lutkenhoff, Martin M Monti
In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to the return of complex cognitive function in general or simply the temporal evolution of post-injury pathophysiological events. To test whether the restoration of thalamo-cortical connectivity is specific to consciousness, 20 moderate-to-severe brain injury patients (from a recruited sample of 42) underwent resting-state functional magnetic resonance imaging within a week after injury and again six months later...
August 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28800634/utilizing-the-r-v-marcus-g-langseth-s-streamer-to-measure-the-acoustic-radiation-of-its-seismic-source-in-the-shallow-waters-of-new-jersey-s-continental-shelf
#5
Timothy J Crone, Maya Tolstoy, James C Gibson, Gregory Mountain
Shallow water marine seismic surveys are necessary to understand a range of Earth processes in coastal environments, including those that represent major hazards to society such as earthquakes, tsunamis, and sea-level rise. Predicting the acoustic radiation of seismic sources in shallow water, which is required for compliance with regulations designed to limit impacts on protected marine species, is a significant challenge in this environment because of variable reflectivity due to local geology, and the susceptibility of relatively small bathymetric features to focus or shadow acoustic energy...
2017: PloS One
https://www.readbyqxmd.com/read/28774583/language-and-motor-function-thresholds-during-pediatric-extra-operative-electrical-cortical-stimulation-brain-mapping
#6
Alonso Zea Vera, Gewalin Aungaroon, Paul S Horn, Anna W Byars, Hansel M Greiner, Jeffrey R Tenney, Todd M Arthur, Nathan E Crone, Katherine D Holland, Francesco T Mangano, Ravindra Arya
OBJECTIVE: To examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS). METHODS: ECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses. RESULTS: In 122 patients (age 11.9±5.4years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3...
July 18, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28759780/neural-correlates-of-evaluating-self-and-close-other-in-physical-academic-and-prosocial-domains
#7
R van der Cruijsen, S Peters, E A Crone
Behavioral studies showed that self-concept can be distinguished into different domains, but few neuroimaging studies have investigated either domain-specific or valence-specific activity. Here, we investigated whether evaluating self- and mother-traits in three domains (physical, academic, prosocial) relies on similar or distinct brain regions. Additionally, we explored the topical discussion in the literature on whether vmPFC activity during self-evaluations is induced by valence or importance of traits. Participants evaluated themselves and their mothers on positive and negative traits in three domains...
July 28, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28740531/a-case-report-hypercalcemia-due-to-vitamin-supplementation-in-a-patient-with-neurofibromatosis
#8
Michael Crone, Kelly Fogarty
A 54-year-old female with history of neurofibromatosis who presented with severe hypercalcemia and renal failure secondary to over supplementation of calcium and vitamin D.
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28729952/nano-sized-zeolites-as-modulators-of-thiacloprid-toxicity-on-chironomus-riparius
#9
Carla S Lorenz, Anna-Jorina Wicht, Leyla Guluzada, Barbara Crone, Uwe Karst, Hwa Jun Lee, Rita Triebskorn, Stefan B Haderlein, Carolin Huhn, Heinz-R Köhler
This study investigated whether zeolites of different size (Y30 (nano-sized) and H-Beta(OH)-III (forming large aggregates/agglomerates composed of 50 nm small primary particles)) exerted acute toxicity on larvae of the non-biting midge, Chironomus riparius, and whether such zeolites are able to modulate the toxicity of a common insecticide, thiacloprid, by means of adsorption of a dissolved toxicant. We conducted acute toxicity tests with fourth instar larvae of C. riparius. In these tests, larvae were exposed to zeolites or thiacloprid solely, or to mixtures of both compounds...
2017: PeerJ
https://www.readbyqxmd.com/read/28709987/the-neural-correlates-of-dealing-with-social-exclusion-in-childhood
#10
Mara van der Meulen, Nikolaus Steinbeis, Michelle Achterberg, Elisabeth Bilo, Bianca G van den Bulk, Marinus H van IJzendoorn, Eveline A Crone
Observing social exclusion can be a distressing experience for children that can be followed by concerns for self-inclusion (self-concerns), as well as prosocial behavior to help others in distress (other-concerns). Indeed, behavioral studies have shown that observed social exclusion elicits prosocial compensating behavior in children, but motivations for the compensation of social exclusion are not well understood. To distinguish between self-concerns and other-concerns when observing social exclusion in childhood, participants (aged 7-10) played a four-player Prosocial Cyberball Game in which they could toss a ball to three other players...
July 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28690513/feature-selection-methods-for-zero-shot-learning-of-neural-activity
#11
Carlos A Caceres, Matthew J Roos, Kyle M Rupp, Griffin Milsap, Nathan E Crone, Michael E Wolmetz, Christopher R Ratto
Dimensionality poses a serious challenge when making predictions from human neuroimaging data. Across imaging modalities, large pools of potential neural features (e.g., responses from particular voxels, electrodes, and temporal windows) have to be related to typically limited sets of stimuli and samples. In recent years, zero-shot prediction models have been introduced for mapping between neural signals and semantic attributes, which allows for classification of stimulus classes not explicitly included in the training set...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28686139/neural-mechanisms-underlying-risk-and-ambiguity-attitudes
#12
Neeltje E Blankenstein, Jiska S Peper, Eveline A Crone, Anna C K van Duijvenvoorde
Individual differences in attitudes to risk (a taste for risk, known probabilities) and ambiguity (a tolerance for uncertainty, unknown probabilities) differentially influence risky decision-making. However, it is not well understood whether risk and ambiguity are coded differently within individuals. Here, we tested whether individual differences in risk and ambiguity attitudes were reflected in distinct neural correlates during choice and outcome processing of risky and ambiguous gambles. To these ends, we developed a neuroimaging task in which participants ( N = 50) chose between a sure gain and a gamble, which was either risky or ambiguous, and presented decision outcomes (gains, no gains)...
July 7, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28629759/development-holds-the-key-to-understanding-the-interplay-of-nature-versus-nurture-in-shaping-the-individual
#13
EDITORIAL
Nikolaus Steinbeis, Eveline Crone, Sarah-Jayne Blakemore, Kathrin Cohen Kadosh
No abstract text is available yet for this article.
June 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28622530/brain-network-dynamics-in-the-human-articulatory-loop
#14
Masaaki Nishida, Anna Korzeniewska, Nathan E Crone, Goichiro Toyoda, Yasuo Nakai, Noa Ofen, Erik C Brown, Eishi Asano
OBJECTIVE: The articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation. METHODS: We measured high-gamma activity70-110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming...
August 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28614733/impact-of-capillary-flow-hydrodynamics-on-carrier-mediated-transport-of-opioid-derivatives-at-the-blood-brain-barrier-based-on-ph-dependent-michaelis-menten-and-crone-renkin-analyses
#15
Siti R Yusof, N Joan Abbott, Alex Avdeef
Most studies of blood-brain barrier (BBB) permeability and transport are conducted at a single pH, but more detailed information can be revealed by using multiple pH values. A pH-dependent biophysical model was applied to the mechanistic analysis of published pH-dependent BBB luminal uptake data from three opioid derivatives in rat: pentazocine (Suzuki et al., 2002a, 2002b), naloxone (Suzuki et al., 2010a), and oxycodone (Okura et al., 2008). Two types of data were processed: in situ brain perfusion (ISBP) and brain uptake index (BUI)...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28611713/assessing-empathy-across-childhood-and-adolescence-validation-of-the-empathy-questionnaire-for-children-and-adolescents-emque-ca
#16
Sandy Overgaauw, Carolien Rieffe, Evelien Broekhof, Eveline A Crone, Berna Güroğlu
Empathy plays a crucial role in healthy social functioning and in maintaining positive social relationships. In this study, 1250 children and adolescents (10-15 year olds) completed the newly developed Empathy Questionnaire for Children and Adolescents (EmQue-CA) that was tested on reliability, construct validity, convergent validity, and concurrent validity. The EmQue-CA aims to assess empathy using the following scales: affective empathy, cognitive empathy, and intention to comfort. A Principal Components Analysis, which was directly tested with a Confirmatory Factor Analysis, confirmed the proposed three-factor model resulting in 14 final items...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28604821/correction-nano-sized-al2o3-reduces-acute-toxic-effects-of-thiacloprid-on-the-non-biting-midge-chironomus-riparius
#17
Carla S Lorenz, Anna-J Wicht, Leyla Guluzada, Leilei Luo, Leonie Jäger, Barbara Crone, Uwe Karst, Rita Triebskorn, Yucang Liang, Reiner Anwander, Stefan B Haderlein, Carolin Huhn, Heinz-R Köhler
[This corrects the article DOI: 10.1371/journal.pone.0176356.].
2017: PloS One
https://www.readbyqxmd.com/read/28553915/-oesophageal-vascular-ectasia-in-a-patient-with-anaemia
#18
Vera Crone, Lasse Bremholm
This case report describes the findings of oesophageal vascular ectasia (OVE) in a patient with known gastric antral vascular ectasia, who presented with anaemia. OVE is a very rare endoscopic finding and therefore a diagnostic challenge. An 85-year-old male was admitted due to anaemia. He went through a gastroscopic examination where severe OVE changes were seen, along with newfound oesophageal varices. There was no need for treating the OVE, but the findings coupled with the knowledge of the varices led to the diagnosis of portal thrombosis...
May 22, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28536516/multi-regional-adaptation-in-human-auditory-association-cortex
#19
Urszula Malinowska, Nathan E Crone, Frederick A Lenz, Mackenzie Cervenka, Dana Boatman-Reich
In auditory cortex, neural responses decrease with stimulus repetition, known as adaptation. Adaptation is thought to facilitate detection of novel sounds and improve perception in noisy environments. Although it is well established that adaptation occurs in primary auditory cortex, it is not known whether adaptation also occurs in higher auditory areas involved in processing complex sounds, such as speech. Resolving this issue is important for understanding the neural bases of adaptation and to avoid potential post-operative deficits after temporal lobe surgery for treatment of focal epilepsy...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28533406/spatiotemporal-dynamics-of-word-retrieval-in-speech-production-revealed-by-cortical-high-frequency-band-activity
#20
Stephanie K Riès, Rummit K Dhillon, Alex Clarke, David King-Stephens, Kenneth D Laxer, Peter B Weber, Rachel A Kuperman, Kurtis I Auguste, Peter Brunner, Gerwin Schalk, Jack J Lin, Josef Parvizi, Nathan E Crone, Nina F Dronkers, Robert T Knight
Word retrieval is core to language production and relies on complementary processes: the rapid activation of lexical and conceptual representations and word selection, which chooses the correct word among semantically related competitors. Lexical and conceptual activation is measured by semantic priming. In contrast, word selection is indexed by semantic interference and is hampered in semantically homogeneous (HOM) contexts. We examined the spatiotemporal dynamics of these complementary processes in a picture naming task with blocks of semantically heterogeneous (HET) or HOM stimuli...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
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