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Christian Borgo, Gabriella Milan, Francesca Favaretto, Fabio Stasi, Roberto Fabris, Valentina Salizzato, Luca Cesaro, Anna Belligoli, Marta Sanna, Mirto Foletto, Luca Prevedello, Vincenzo Vindigni, Romeo Bardini, Arianna Donella-Deana, Roberto Vettor
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal muscle and its acute inhibition impairs glucose tolerance...
December 14, 2017: Scientific Reports
Joanna A Zielińska, Morgan W Mitchell
We demonstrate a nonlinear optical resonator that tunes itself onto resonance with an input beam. In a monolithic Fabry-Perot cavity implemented in rubidium-doped periodically poled potassium titanyl phosphate, an intensity-dependent refractive index produces line pulling by multiple free-spectral ranges (FSRs). In this condition, the cavity passively maintains optical resonance in the face of FSR-scale excursions of the drive laser frequency: when one resonant operating point becomes unstable, the resonator rapidly transitions to another resonant operating point...
December 15, 2017: Optics Letters
Qingzhong Huang, Qiang Liu, Jinsong Xia
We have proposed and studied a novel channel add-drop filter (ADF) based on a single Fabry-Perot resonator. The resonator consists of two mode-conversion Bragg grating reflectors separated by a wide waveguide that laterally coupled to two narrow waveguides. It behaves like a traveling-wave resonator where fields are coupled to the buses in one direction. Compact and narrowband ADFs are achieved with dropping efficiencies higher than 95%, as shown by the three-dimensional finite-difference time-domain simulations...
December 15, 2017: Optics Letters
Baptiste Fix, Julien Jaeck, Patrick Bouchon, Sébastien Héron, Benjamin Vest, Riad Haïdar
Fabry-Perot (FP)-like resonances have been widely described in nanoantennas. In the original FP resonator, a third mirror can be added, resulting in a multimirror interferometer. However, in the case of a combination of nanoantennas, it has been reported that each cavity behaves independently. Here, we evidence the interferences between two FP absorbing nanoantennas through a common mirror, which has a strong impact on the optical behavior. While the resonance wavelength is only slightly shifted, the level of absorption reaches nearly 100%...
December 15, 2017: Optics Letters
Wenjing Li, Qing Wang, Yalong Wang, Yalan Wang, Chunqing Gao
We demonstrate a tunable single-longitudinal-mode Ho:YAG laser pumped by a 1.13 μm diode. With two intracavity Fabry-Perot etalons, the maximum single-longitudinal-mode output power of 102 mW at 2129.6 nm is obtained. The wavelength is tuned from 2119.7 to 2131.5 nm by precisely rotating two etalons. The measured beam quality factors M2 are 1.29 and 1.28 in the x and y directions, respectively.
December 10, 2017: Applied Optics
Peijian Huang, Ning Wang, Junying Li, Yong Zhu, Jie Zhang
Measuring the radial collision force between the steam generator tube (SGT) and the tube support plate (TSP) is essential to assess the fretting damage of the SGT. In order to measure the radial collision force, a novel miniaturized force sensor based on fiber Fabry-Perot (F-P) was designed, and the principle and characteristics of the sensor were analyzed in detail. Then, the F-P force sensor was successfully fabricated and calibrated, and the overall dimensions of the encapsulated fiber F-P sensor were 17 mm × 5 mm × 3 mm (L × W × H)...
December 13, 2017: Sensors
Raphael Schiffmann, Caren Swift, Nathan McNeill, Elfrida R Benjamin, Jeffrey P Castelli, Jay Barth, Lawrence Sweetman, Xuan Wang, Xiaoyang Wu
PurposeTo test the hypothesis that undiagnosed patients with Fabry disease exist among patients affected by common heart disease.MethodsGlobotriaosylceramide in random whole urine using tandem mass spectroscopy, α-galactosidase A activity in dried blood spots, and next-generation sequencing of pooled or individual genomic DNA samples supplemented by Sanger sequencing.ResultsWe tested 2,256 consecutive patients: 852 women (median age 65 years (19-95)) and 1,404 men (median age 65 years (21-92)). The primary diagnoses were coronary artery disease (n = 994), arrhythmia (n = 607), cardiomyopathy (n = 138), and valvular disease (n = 568)...
October 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Toti Paolo, Barone Antonio, Marconcini Simone, Menchini-Fabris Giovanni Battista, Martuscelli Ranieri, Covani Ugo
OBJECTIVES: The aim of the study was to introduce a mathematical method to estimate the correct pose of a blade by evaluating the radiographic features obtained from a single two-dimensional image. METHODS: Blade-form implant bed preparation was performed using the piezosurgery device, and placement was attained with the use of magnetic mallet. The pose determination of the blade was described by means of three consecutive rotations defined by three angles of orientation (triplet φ, θ and Ψ)...
December 11, 2017: Dento Maxillo Facial Radiology
Irmgard Streitlein-Böhme, Wilhelm Niebling, Götz Fabry, Klaus Böhme
Introduction: An oral exam (30-60 minutes) is administered at the end of every post-graduate medical specialty program or is required to attain additional specialized qualifications. In both undergraduate and post-graduate medical education oral exams are not considered to be very objective or reliable. To improve the quality of exams in medical specialties, the Regional Medical Association for South Baden (Bezirksärztekammer Südbaden) decided in 2013 to offer a training program for head examiners and others responsible for administering exams in medical specialties...
2017: GMS Journal for Medical Education
Ran Ditcovski, Tal Ellenbogen
We use numerical simulations to study the effects of nanowire geometry on the emission spectra of nanowire-based lasers. The studied nanowire lasers are made from gallium-nitride and the simulations are performed using finite difference time domain method. We show that changes in the diameter of the nanowire lasers also change the effective refractive index of their optical guided modes, which allows control over their Fabry-Perot spectrum. In addition, we show that evanescent coupling of two vertically standing nanowire lasers, having different cross section sizes, leads to a Vernier effect, which results in single mode emission from the small footprint coupled lasers system...
November 27, 2017: Optics Express
Kunjian Cao, Yi Liu, Shiliang Qu
A compact and robust fiber temperature sensor based on a hermetically-sealed liquid-filling Fabry-Perot (FP) cavity was fabricated by low-cost but efficient processes, including fusion splicing, liquid injection, and fused tapering. Owing to the high thermal optical coefficient (TOC) of the ethanol, the optical path difference (OPD) in the FP cavity varied strongly with temperature, which consequently induced a drastic wavelength shift of the reflection spectrum. Meanwhile, the low freezing point of the ethanol caused the fiber sensor to have the ability of detecting the sub-zero temperatures...
November 27, 2017: Optics Express
Jian Zhou, Yonggang Wu, Zihuan Xia, Xuefei Qin, Zongyi Zhang
Single nanowire solar cells show great promise for next-generation photovoltaics and for powering nanoscale devices. Here, we present a detailed study of light absorption in a single standing semiconductor-dielectric core-shell nanowire (CSNW). We find that the CSNW structure can not only concentrate the incident light into the structure, but also confine most of the concentrated light to the semiconductor core region, which boosts remarkably the light absorption cross-section of the semiconductor core. The CSNW can support multiple higher-order HE modes, as well as Fabry-Pérot (F-P) resonance, compared to the bare nanowire (BNW)...
November 27, 2017: Optics Express
Jinlong Zhang, Han Wu, Hongfei Jiao, Sven Schröder, Marcus Trost, Zhanshan Wang, Xinbin Cheng
Light scattering in quarter-wave high-reflection (QWHR) coatings with fully correlated interfaces was reduced by adding Fabry-Perot (FP) cavity structures on top of the multilayer. The properly designed FP cavity can induce destructive interference for fully correlated interfaces and reduce the scattering loss. Compared to QWHR coatings, adding one FP cavity could decrease the scattering at the near specular angles, and two FP cavities have the potential to reduce light scattering in a broad angular range. A low-scattering HR (LSHR) coating using two FP cavities has been realized to suppress light scattering...
December 1, 2017: Optics Letters
Sergiy Suntsov, Christian E Rüter, Tom Schipkowski, Detlef Kip
We report on a fiber-integrated refractive index sensor based on a Fabry-Perot micro-resonator fabricated using simple diamond blade dicing of a single-mode step-index fiber. The performance of the device has been tested for the refractive index measurements of sucrose solutions as well as in air. The device shows a sensitivity of 1160 nm/RIU (refractive index unit) at a wavelength of 1.55 μm and a temperature cross-sensitivity of less than 10-7  RIU/°C. Based on evaluation of the broadband reflection spectra, refractive index steps of 10-5 of the solutions were accurately measured...
November 20, 2017: Applied Optics
Yung-Hsiu Lu, Po-Hsun Huang, Li-Yun Wang, Ting-Rong Hsu, Hsing-Yuan Li, Pi-Chang Lee, Yu-Ping Hsieh, Sheng-Che Hung, Yu-Chen Wang, Sheng-Kai Chang, Ya-Ting Lee, Ping-Hsun Ho, Hui-Chen Ho, Dau-Ming Niu
Many female carriers of Fabry disease are likely to develop severe morbidity and mortality. However, by our own estimation, around 80% of female newborns are missed by our current enzyme-based screening approach. Our team's aim was to develop an improved cost-effective screening method that is able to detect Fabry disease among female newborns. In Taiwan, based on a database of 916,000 newborns, ~98% of Fabry patients carry mutations out of a pool of only 21 pathogenic mutations. An Agena iPLEX platform was designed to detect these 21 pathogenic mutations using only a single-assay panel...
November 15, 2017: Journal of Human Genetics
Qixin He, Minhan Lou, Chuantao Zheng, Weilin Ye, Yiding Wang, Frank K Tittel
A Pound-Drever-Hall (PDH)-based mode-locked cavity-enhanced sensor system was developed using a distributed feedback diode laser centered at 1.53 µm as the laser source. Laser temperature scanning, bias control of the piezoelectric ceramic transducer (PZT) and proportional-integral-derivative (PID) feedback control of diode laser current were used to repetitively lock the laser modes to the cavity modes. A gas absorption spectrum was obtained by using a series of absorption data from the discrete mode-locked points...
December 2, 2017: Sensors
Yu-Cheng Chen, Xiaotian Tan, Qihan Sun, Qiushu Chen, Wenjie Wang, Xudong Fan
Detection of nuclear biomarkers such as nucleic acids and nuclear proteins is critical for early-stage cancer diagnosis and prognosis. Conventional methods relying on morphological assessment of cell nuclei in histopathology slides may be subjective, whereas colorimetric immunohistochemical and fluorescence-based imaging are limited by strong light absorption, broad-emission bands and low contrast. Here, we describe the development and use of a scanning laser-emission-based microscope that maps lasing emissions from nuclear biomarkers in human tissues...
2017: Nature Biomedical Engineering
Toshiyuki Yano, Ryo Takahashi, Tomohisa Yamashita, Nobutaka Nagano, Aki Ishikawa, Akihiro Sakurai, Hiroki Maruyama, Tetsuji Miura
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
Mario H Cardiel, Enrique R Soriano, Eloisa Silva Dutra de Oliveira Bonfá, Graciela S Alarcón, Ariel Izcovich, Mary Carmen Amigo Castañeda, Leonor A Barile-Fabris, Margarita Duarte, Graciela Espada, Mercedes A García, Roger A Levy, Loreto Massardo, Emilia I Sato, Gloria Vásquez, Eduardo M Acevedo-Vásquez, Luis J Catoggio, Rosa Chacón-Díaz, Claudio M Galarza Maldonado, Antonio J Iglesias Gamarra, José F Molina Restrepo, Oscar Neira, Clovis A Silva, Andrea Vargas Peña, Bernardo A Pons-Estel
No abstract text is available yet for this article.
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Yang Du, Yizheng Chen, Chen Zhu, Yiyang Zhuang, Jie Huang
We report, for the first time, a low cost, compact, and novel mechanically designed extrinsic Fabry-Perot interferometer (EFPI)-based optical fiber sensor with a strain amplification mechanism for strain measurement. The fundamental design principle includes a buckled beam with a coated gold layer, mounted on two grips. A Fabry-Perot cavity is produced between the buckled beam and the endface of a single mode fiber (SMF). A ceramic ferrule is applied for supporting and orienting the SMF. The principal sensor elements are packaged and protected by two designed metal shells...
November 2017: Review of Scientific Instruments
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