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https://www.readbyqxmd.com/read/28416538/susceptibility-testing-of-common-and-uncommon-aspergillus-species-against-posaconazole-and-other-mold-active-antifungal-azoles-using-the-sensititre-method
#1
Enrica Mello, Brunella Posteraro, Antonietta Vella, Elena De Carolis, Riccardo Torelli, Tiziana D'Inzeo, Paul E Verweij, Maurizio Sanguinetti
We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28414857/association-of-external-cephalic-version-before-term-with-late-preterm-birth
#2
Kristie L Poole, Sarah D McDonald, Lauren E Griffith, Eileen K Hutton
While evidence suggests that beginning an external cephalic version (ECV) before term (34(0/7) to 36(6/7) ) compared to after term may be associated with an increase in late preterm birth (34(0/7) to 36(6/7) weeks), it remains unknown what might account for this risk. The objective of the present study is to further investigate the association between ECV before term and late preterm birth MATERIAL AND METHODS: Secondary analysis of data collected from the international, multicenter Early ECV trials. We evaluated the relation between ECV exposure and late preterm birth (34(0/7) to 36(6/7) weeks), as well as if additional risk factors for preterm birth (e...
April 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28412435/cmr-derived-extracellular-volume-fraction-as-a-marker%C3%A2-for-myocardial-fibrosis-the-importance-of-coexisting-myocardial-inflammation
#3
Julia Anna Lurz, Christian Luecke, David Lang, Christian Besler, Karl-Philipp Rommel, Karin Klingel, Reinhard Kandolf, Volker Adams, Katharina Schöne, Gerhard Hindricks, Gerhard Schuler, Axel Linke, Holger Thiele, Matthias Gutberlet, Philipp Lurz
OBJECTIVES: The aim of the present study was to evaluate whether extracellular volume fraction (ECV) can reliably inform on the extent of diffuse fibrosis in the simultaneous presence of myocardial inflammation, which has not been verified to date. BACKGROUND: Diffuse myocardial fibrosis is associated with unfavorable outcome in patients with cardiomyopathy, and is of prognostic relevance. Assessment of ECV bears promise for being a noninvasive surrogate parameter, but it may be altered by other pathologies...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28382028/notable-increasing-trend-in-azole-non-susceptible-candida-tropicalis-causing-invasive-candidiasis-in-china-august-2009-to-july-2014-molecular-epidemiology-and-clinical-azole-consumption
#4
Xin Fan, Meng Xiao, Kang Liao, Timothy Kudinha, He Wang, Li Zhang, Xin Hou, Fanrong Kong, Ying-Chun Xu
Objectives: To report the notable increasing trends of C. tropicalis antifungal resistance in the past 5 years, and explore molecular epidemiology, and the relationship between clinical azoles consumption and increased resistance rate. Methods: Between August 2009 and July 2014, 507 non-duplicated C. tropicalis isolates causing invasive candidiasis were collected from 10 hospitals in China. The in vitro antifungal susceptibility of nine common agents was determined by Sensititre YeastOne™ using current available species-specific clinical breakpoint (CBPs) or epidemiological cut-off values (ECVs)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28380246/matched-cohort-study-of-external-cephalic-version-in-women-with-previous-cesarean-delivery
#5
Anish Keepanasseril, Keerthana Anand, S Soundara Raghavan
OBJECTIVE: To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. METHODS: A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included...
April 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28373647/fibrosis-quantification-in-hypertensive-heart-disease-with-lvh-and-non-lvh-findings-from-t1-mapping-and-contrast-free-cardiac-diffusion-weighted-imaging
#6
Lian-Ming Wu, Rui Wu, Yang-Rongzheng Ou, Bing-Hua Chen, Qiu-Ying Yao, Qing Lu, Jiani Hu, Meng Jiang, Dong-Aolei An, Jian-Rong Xu
This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28364177/magnetic-resonance-imaging-for-characterizing-myocardial-diseases
#7
REVIEW
Maythem Saeed, Hui Liu, Chang-Hong Liang, Mark W Wilson
The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases. It provides information on myocardial structure/orientation, perfusion, function and viability in diseases related to cardiomyopathy. The standard cardiac magnetic resonance imaging (MRI) sequences can reveal insight on left ventricular (LV) mass, volumes and regional contractile function in all types of cardiomyopathy diseases...
March 31, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28347204/the-effect-of-echis-coloratus-venom-on-biochemical-and-molecular-markers-of-the-antioxidant-capacity-in-human-fibroblasts
#8
Hazem K Ghneim
This study was undertaken to examine the activities and levels of major antioxidants/oxidants in cultured human fibroblasts incubated with a sublethal dose of Echis coloratus venom (EcV). Glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) activities and gene expression levels as well as reduced glutathione (GSH) levels, and the concurrent hydrogen peroxide (H2O2), superoxide anions (SOA), lipid peroxides (LPO) and oxidized glutathione (GSSG) generation rates were assayed in fibroblast cultures and sonicates incubated with 0...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28341414/myocardial-extracellular-volume-is-not-associated-with-malignant-ventricular-arrhythmias-in-high-risk-hypertrophic-cardiomyopathy
#9
Jesús G Mirelis, Javier Sánchez-González, Esther Zorio, Tomas Ripoll-Vera, Rafael Salguero-Bodes, David Filgueiras-Rama, Esther González-López, María Gallego-Delgado, Rodrigo Fernández-Jiménez, María Jesús Soleto, Juana Núñez, Gonzalo Pizarro, Javier Sanz, Valentín Fuster, Pablo García-Pavía, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Myocardial interstitial fibrosis, a hallmark of hypertrophic cardiomyopathy (HCM), has been proposed as an arrhythmic substrate. Fibrosis is associated with increased extracellular volume (ECV), which can be quantified by computed tomography (CT). We aimed to analyze the association between CT-determined ECV and malignant ventricular arrhythmias. METHODS: A retrospective case-control observational study was conducted in HCM patients with implantable cardioverter-defibrillator, undergoing a CT-protocol with continuous iodine contrast infusion to determine equilibrium ECV...
March 21, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28338005/the-association-between-diffuse-myocardial-fibrosis-on-cardiac-magnetic-resonance-t1-mapping-and-myocardial-dysfunction-in-diabetic-rabbits
#10
Mu Zeng, Yingyan Qiao, Zhaoying Wen, Jun Liu, Enhua Xiao, Changlian Tan, Yibin Xie, Jing An, Zishu Zhang, Zhanming Fan, Debiao Li
The objective of this study was to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfunction. Thirty-six New Zealand white rabbits were classified into two groups: a control group (n = 18) and an alloxan-induced diabetes mellitus (DM) group (n = 18). For all rabbits, conventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T1 mapping were performed; all of the rabbits were then sacrificed for Masson's staining. The extracellular volume (ECV) was calculated from pre- and post-contrast T1 values and compared with myocardial function measured by echocardiography using Pearson's correlation...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28329275/tissue-characterization-by-t1-and-t2-mapping-cardiovascular-magnetic-resonance-imaging-to-monitor-myocardial-inflammation-in-healing-myocarditis
#11
S Bohnen, U K Radunski, G K Lund, F Ojeda, Y Looft, M Senel, L Radziwolek, M Avanesov, E Tahir, C Stehning, B Schnackenburg, G Adam, S Blankenberg, K Muellerleile
Aims: Monitoring disease activity in myocarditis is important for tailored therapeutic strategies. This study evaluated the ability of T1 and T2 mapping cardiovascular magnetic resonance (CMR) to monitor the course of myocardial inflammation in healing myocarditis. Methods and results: Forty-eight patients with strictly defined acute myocarditis underwent CMR at 1.5 T in the acute stage, at 3-months (n = 39), and at 12-months follow-up (FU) (n = 21). Normal values were obtained in a control group of 27 healthy subjects...
March 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28328052/a-century-of-changing-views-on-ecv
#12
Philip J Steer
No abstract text is available yet for this article.
April 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28296735/remifentanil-analgesia-during-external-cephalic-version-for-breech-presentation-in-nulliparous-women-at-term-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Zhi-Hong Wang, Yi Yang, Gui-Ping Xu
BACKGROUND: The aim of the study was to assess the efficacy and safety of remifentanil for pain relief during external cephalic version (ECV) for breech presentation in nulliparous women at term. METHODS: A total of 144 nulliparous women with singleton breech presentation were randomly divided into the intervention group and the placebo group, with 72 subjects in each group. The subjects in the intervention group received remifentanil (infused at 0.1 μg kg min with demand boluses of 0...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28279119/amnioinfusion-for-women-with-a-singleton-breech-presentation-and-a-previous-failed-external-cephalic-version-a-randomized-controlled-trial
#14
Caroline Diguisto, Norbert Winer, Celine Descriaud, Elsa Tavernier, Victoire Weymuller, Bruno Giraudeau, Franck Perrotin
Purpose Our trial aimed to assess the effectiveness of amnioinfusion for a second attempt at external cephalic version (ECV). Material and methods This open randomized controlled trial was planned with a sequential design. Women at a term ≥ 36 weeks of gestation with a singleton fetus in breech presentation and a first unsuccessful ECV were recruited in two level-3 maternity units. They were randomly allocated to transabdominal amnioinfusion with a 500-mL saline solution under ultrasound surveillance or no amnioinfusion before the second ECV attempt...
March 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28268091/automatic-quantification-of-the-myocardial-extracellular-volume-by-cardiac-computed-tomography-synthetic-ecv-by-cct
#15
Thomas A Treibel, Marianna Fontana, Jennifer A Steeden, Arthur Nasis, Jason Yeung, Steven K White, Sri Sivarajan, Shonit Punwani, Francesca Pugliese, Stuart A Taylor, James C Moon, Steve Bandula
BACKGROUND: The quantification of extracellular volume fraction (ECV) by Cardiac Computed Tomography (CCT) can identify changes in the myocardial interstitium due to fibrosis or infiltration. Current methodologies require laboratory blood hematocrit (Hct) measurement - which complicates the technique. The attenuation of blood (HUblood) is known to change with anemia. We hypothesized that the relationship between Hct and HUblood could be calibrated to rapidly generate a synthetic ECV without formally measuring Hct...
February 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28247214/accuracy-of-computer-aided-diagnosis-based-on-narrow-band-imaging-endocytoscopy-for-diagnosing-colorectal-lesions-comparison-with-experts
#16
Masashi Misawa, Shin-Ei Kudo, Yuichi Mori, Kenichi Takeda, Yasuharu Maeda, Shinichi Kataoka, Hiroki Nakamura, Toyoki Kudo, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Toshiyuki Baba, Fumio Ishida, Haruhiro Inoue, Yukitaka Nimura, Msahiro Oda, Kensaku Mori
PURPOSE: Real-time characterization of colorectal lesions during colonoscopy is important for reducing medical costs, given that the need for a pathological diagnosis can be omitted if the accuracy of the diagnostic modality is sufficiently high. However, it is sometimes difficult for community-based gastroenterologists to achieve the required level of diagnostic accuracy. In this regard, we developed a computer-aided diagnosis (CAD) system based on endocytoscopy (EC) to evaluate cellular, glandular, and vessel structure atypia in vivo...
February 28, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28240638/measurement-of-myocardial-extracellular-volume-fraction-from-iodine-density-images-using-single-source-dual-energy-computed-tomography-a-feasibility-study
#17
Yasutoshi Ohta, Shinichiro Kitao, Tomomi Watanabe, Natsuko Mukai, Junichi Kishimoto, Kazuhiro Yamamoto, Toshihide Ogawa
OBJECTIVE: The aims of this study were to develop and validate an iodine density method for the quantification of myocardial extracellular volume (ECV) fraction using single-source, dual-energy computed tomography. METHODS: Extracellular volume measurements were carried out in 40 subjects (20 patients with heart failure, 20 control subjects) using single-source, dual-energy computed tomography. Subtraction-derived ECVs (subECVs) were computed by subtracting precontrast from delayed images...
February 24, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28238321/-cord-accident-after-external-cephalic-version-reality-or-mostly-myth
#18
J Boujenah, C Fleury, I Pharisien, A Benbara, A Tigaizin, A Bricou, L Carbillon
OBJECTIVES: To study the occurrence of cords accident (nuchal cords, prolapse, and braces) after external cephalic version according to its failure or success. METHODS: Retrospective study between 1998-2015 comparing in the cord accident diagnosed at delivery (by midwife or doctors according to mode of delivery): Patients with attempt ECV: Group 1 cephalic presentation after successful ECV with trial of labor, and Group 2 failed ECV followed by elective cesarean or trial of labor...
January 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28217222/non-vitamin-k-antagonist-oral-anticoagulants-versus-warfarin-for-cardioversion-of-atrial-fibrillation-in-clinical-practice-a-single-center-experience
#19
Naoki Shibata, Itsuro Morishima, Kenji Okumura, Yasuhiro Morita, Kensuke Takagi, Ruka Yoshida, Hiroaki Nagai, Toshiro Tomomatsu, Yoshihiro Ikai, Kazushi Terada, Kazuhito Tsuzuki, Hideyuki Tsuboi, Takahito Sone, Toyoaki Murohara
BACKGROUND: Anticoagulation therapy with the vitamin K antagonist (VKA) warfarin has been demonstrated to reduce thromboembolic risk after electrical cardioversion (ECV). However, data concerning ECV with non-VKA oral anticoagulants (NOACs) is limited. The objective of this study was to determine the efficacy and safety of NOACs in patients undergoing ECV in a real-world clinical practice at a single center in Japan. METHODS: We retrospectively analyzed the data of 406 consecutive patients who underwent ECV for atrial fibrillation (AF) or flutter under anticoagulation with one of the three NOACs (n=149) or with a VKA (n=257)...
February 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28215181/effect-of-cellular-and-extracellular-pathology-assessed-by-t1-mapping-on-regional-contractile-function-in-hypertrophic-cardiomyopathy
#20
Peter P Swoboda, Adam K McDiarmid, Bara Erhayiem, Graham R Law, Pankaj Garg, David A Broadbent, David P Ripley, Tarique A Musa, Laura E Dobson, James R Foley, Graham J Fent, Stephen P Page, John P Greenwood, Sven Plein
BACKGROUND: Regional contractile dysfunction is a frequent finding in hypertrophic cardiomyopathy (HCM). We aimed to investigate the contribution of different tissue characteristics in HCM to regional contractile dysfunction. METHODS: We prospectively recruited 50 patients with HCM who underwent cardiovascular magnetic resonance (CMR) studies at 3.0 T including cine imaging, T1 mapping and late gadolinium enhancement (LGE) imaging. For each segment of the American Heart Association model segment thickness, native T1, extracellular volume (ECV), presence of LGE and regional strain (by feature tracking and tissue tagging) were assessed...
February 20, 2017: Journal of Cardiovascular Magnetic Resonance
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