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https://www.readbyqxmd.com/read/28202791/establishment-and-use-of-epidemiological-cutoff-values-for-molds-and-yeasts-using-the-clinical-and-laboratory-standards-institute-m57-standard
#1
Shawn R Lockhart, Mahmoud A Ghannoum, Barbara D Alexander
Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values and clinical outcome data. For many fungus/antifungal combinations this data will never be available. For these combinations Epidemiological Cutoff Values (ECVs) provide a methodology to categorize isolates as either wild type or non-wild type. This review defines ECVs, explains how they are generated using the CLSI methodology in standard M57, and describes how they can be used in clinical practice...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28183646/zwitterionic-phosphorylcholine-grafted-chitosan-nanofiber-preparation-characterization-and-in-vitro-cell-adhesion-behavior
#2
Burcu Oktay, Nilhan Kayaman-Apohan, Mediha Süleymanoğlu, Serap Erdem-Kuruca
In this study, zwitterionic phosphorylcholine grafted electrospun chitosan fiber was accomplished in three steps: (1) Azide groups on the chitosan were regioselectively replaced with hydroxyl side group and then the product was electrospun. (2) Chitosan based macroinitiator was prepared using an azide-alkyne click reaction from azide-functionalized electrospun chitosan fiber. (3) Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) was grafted onto the electrospun chitosan fiber by atom transfer radical polymerization (ATRP) in order to enhance cellular viability and proliferation of 3T3, ECV and Saos...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28179611/asymptomatic-cocaine-abuse%C3%A3-myocardial-tissue-characterization-using-cardiac-biomarkers-and-cardiovascular-magnetic-resonance-imaging
#3
Ulf K Radunski, Ulrike Fuger, Sebastian Bohnen, Gunnar K Lund, Christian Stehning, Tanja Zeller, Enver Tahir, Maxim Avanesov, Gerhard Adam, Stefan Blankenberg, Jens Reimer, Kai Muellerleile
BACKGROUND: Use of cocaine is widespread and associated with several cardiovascular diseases. Recent CMR studies indicate frequent myocardial scar/fibrosis in asymptomatic cocaine abusers (CA).Methods and Results:This study used a combination of advanced CMR tissue characterization techniques, including late gadolinium enhancement (LGE) for focal, and extracellular volume (ECV) imaging for diffuse myocardial injury/fibrosis, with circulating biomarkers for a comprehensive characterization of myocardial injury...
February 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28143545/histological-validation-of-cardiovascular-magnetic-resonance-t1-mapping-markers-of-myocardial-fibrosis-in-paediatric-heart-transplant-recipients
#4
Seiko Ide, Eugenie Riesenkampff, David A Chiasson, Anne I Dipchand, Paul F Kantor, Rajiv R Chaturvedi, Shi-Joon Yoo, Lars Grosse-Wortmann
BACKGROUND: Adverse fibrotic remodeling is detrimental to myocardial health and a reliable method for monitoring the development of fibrotic remodeling may be desirable during the follow-up of patients after heart transplantation (HTx). Quantification of diffuse myocardial fibrosis with cardiovascular magnetic resonance (CMR) has been increasingly applied and validated histologically in adult patients with heart disease. However, comparisons of CMR findings with histological fibrosis burden in children are lacking...
February 1, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28131122/obstetric-and-anesthetic-approaches-to-external-cephalic-version
#5
REVIEW
Stephanie Lim, Jennifer Lucero
Breech presentation is the most common abnormal fetal presentation and complicates approximately 3% to 4% of all pregnancies. External cephalic version (ECV) should be recommended to women with a breech singleton pregnancy, if there is no maternal or fetal contraindication. ECV increases the chance of cephalic presentation at the onset of labor and decreases the rate of cesarean delivery by almost 40%. The success rate of ECV is approximately 60%. Review of the risks and benefits for performing an ECV and for both the timing of ECV and the number of attempts should be should be discussed with the patient...
March 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28126898/atosiban-versus-fenoterol-as-a-uterine-relaxant-for-external-cephalic-version-randomised-controlled-trial
#6
Joost Velzel, Floortje Vlemmix, Brent C Opmeer, Jan F M Molkenboer, Corine J Verhoeven, Mariëlle G van Pampus, Dimitri N M Papatsonis, Joke M J Bais, Karlijn C Vollebregt, Liesbeth van der Esch, Joris A M Van der Post, Ben Willem Mol, Marjolein Kok
OBJECTIVE:  To compare the effectiveness of the oxytocin receptor antagonist atosiban with the beta mimetic fenoterol as uterine relaxants in women undergoing external cephalic version (ECV) for breech presentation. DESIGN:  Multicentre, open label, randomised controlled trial. SETTING:  Eight hospitals in the Netherlands, August 2009 to May 2014. PARTICIPANTS:  830 women with a singleton fetus in breech presentation and a gestational age of more than 34 weeks were randomly allocated in a 1:1 ratio to either 6...
January 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28111363/diffuse-myocardial-fibrosis-reduces-electrocardiographic-voltage-measures-of-left-ventricular-hypertrophy-independent-of-left-ventricular-mass
#7
Maren Maanja, Björn Wieslander, Todd T Schlegel, Ljuba Bacharova, Hussein Abu Daya, Yaron Fridman, Timothy C Wong, Erik B Schelbert, Martin Ugander
BACKGROUND: Myocardial fibrosis quantified by myocardial extracellular volume fraction (ECV) and left ventricular mass (LVM) index (LVMI) measured by cardiovascular magnetic resonance might represent independent and opposing contributors to ECG voltage measures of left ventricular hypertrophy (LVH). Diffuse myocardial fibrosis can occur in LVH and interfere with ECG voltage measures. This phenomenon could explain the decreased sensitivity of LVH detectable by ECG, a fundamental diagnostic tool in cardiology...
January 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28108873/does-employment-related-resilience-affect-the-relationship-between-childhood-adversity-community-violence-and-depression
#8
Seth L Welles, Falguni Patel, Mariana Chilton
Depression is a barrier to employment among low-income caregivers receiving Temporary Assistance for Needy Families (TANF), and adverse childhood experiences (ACEs) and exposure to community violence (ECV) are often associated with depression. Using baseline data of 103 TANF caregivers of young children of the Building Wealth and Health Network Randomized Controlled Trial Pilot, this study investigated associations of two forms of employment-related resilience-self-efficacy and employment hope-with exposure to adversity/violence and depression, measured by the Center for Epidemiologic Studies Depression (CES-D) short form...
January 20, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28100174/prediction-of-ineffective-elective-cardioversion-of-atrial-fibrillation-a-retrospective-multi-center-patient-cohort-study
#9
Tapio Hellman, Tuomas Kiviniemi, Tuija Vasankari, Ilpo Nuotio, Fausto Biancari, Aissa Bah, Juha Hartikainen, Marianne Mäkäräinen, K E Juhani Airaksinen
BACKGROUND: Elective cardioversion (ECV) of atrial fibrillation (AF) is a standard procedure to restore sinus rhythm. However, predictors for ineffective ECV (failure of ECV or recurrence of AF within 30 days) are unknown. METHODS: We investigated 1998 ECVs performed for AF lasting >48 h in 1,342 patients in a retrospective multi-center study. Follow-up data were collected from 30 days after ECV. RESULTS: Median number of cardioversions was one per patient with a range of 1-10...
January 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28096723/myocardial-t1-and-t2-mapping-techniques-and-clinical-applications
#10
REVIEW
Pan Ki Kim, Yoo Jin Hong, Dong Jin Im, Young Joo Suh, Chul Hwan Park, Jin Young Kim, Suyon Chang, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi
Cardiac magnetic resonance (CMR) imaging is widely used in various medical fields related to cardiovascular diseases. Rapid technological innovations in magnetic resonance imaging in recent times have resulted in the development of new techniques for CMR imaging. T1 and T2 image mapping sequences enable the direct quantification of T1, T2, and extracellular volume fraction (ECV) values of the myocardium, leading to the progressive integration of these sequences into routine CMR settings. Currently, T1, T2, and ECV values are being recognized as not only robust biomarkers for diagnosis of cardiomyopathies, but also predictive factors for treatment monitoring and prognosis...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28077133/t1-and-t2-mapping-for-evaluation-of-myocardial-involvement-in-patients-with-anca-associated-vasculitides
#11
Simon Greulich, Agnes Mayr, Daniel Kitterer, Joerg Latus, Joerg Henes, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting with no or nonspecific symptoms, normal ECG, and preserved left-ventricular ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due to myocardial involvement, a reliable diagnostic tool is warranted. In contrast to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic processes, recent mapping techniques are able to detect even subtle, diffuse inflammatory or fibrotic processes...
January 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28069273/does-antiarrhythmic-drugs-premedication-improve-electrical-cardioversion-success-in-persistent-atrial-fibrillation
#12
Elisabetta Toso, Mario Iannaccone, Domenico Caponi, Francesco Rotondi, Antonio Santoro, Cristina Gallo, Marco Scaglione, Fiorenzo Gaita
AIMS: Aim of this study is to evaluate the impact of antiarrhythmic drugs (AADs) administration for at least one month before ECV on the acute and long term success rate of the procedure. METHODS: 1313 consecutive persistent AF patients were enrolled in 3 different centers (Turin, Asti and Avellino): 692 patients received AADs before and after ECV (group A), 621 patients were treated only after the procedure, at discharge (group B). Primary end point was the restoration and maintenance of sinus rhythm acutely and at a long-term follow up...
December 29, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28058227/magnetic-resonance-imaging-of-the-transplanted-pediatric-heart-as-a-potential-predictor-of-rejection
#13
Steven C Greenway, Frederic Dallaire, Paul F Kantor, Anne I Dipchand, Rajiv R Chaturvedi, Monali Warade, Eugenie Riesenkampff, Shi-Joon Yoo, Lars Grosse-Wortmann
AIM: To evaluate cardiac magnetic resonance imaging (CMR) as a non-invasive tool to detect acute cellular rejection (ACR) in children after heart transplant (HT). METHODS: Thirty pediatric HT recipients underwent CMR at the time of surveillance endomyocardial biopsy (EMB) and results were compared to 14 non-transplant controls. Biventricular volumes, ejection fractions (EFs), T2-weighted signal intensities, native T1 times, extracellular volumes (ECVs) and presence of late gadolinium enhancement (LGE) were compared between patients and controls and between patients with International Society of Heart and Lung Transplantation (ISHLT) grade ≥ 2R rejection and those with grade 0/1R...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28042730/sex-age-and-time-to-cardioversion-risk-factors-for-cardioversion-of-acute-atrial-fibrillation-from-the-fincv-study
#14
Aissa Bah, Ilpo Nuotio, Toni Grönberg, Antti Ylitalo, K E Juhani Airaksinen, Juha E K Hartikainen
BACKGROUND: Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in anticoagulant-naive patients with acute AF. METHODS AND RESULTS: The primary outcome was a TEC within 30 days following ECV. Patients were divided into three age groups and time to cardioversion into <12 h and ≥12 h in 4715 ECVs...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/28040512/extracellular-vesicles-of-the-blood-brain-barrier-role-in-the-hiv-1-associated-amyloid-beta-pathology
#15
Ibolya E András, Ana Leda, Marta Garcia Contreras, Luc Bertrand, Minseon Park, Marta Skowronska, Michal Toborek
HIV-infected brains are characterized by increased amyloid beta (Aβ) deposition. It is believed that the blood-brain barrier (BBB) is critical for Aβ homeostasis and contributes to Aβ accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in Aβ pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced Aβ pathology in the brain...
March 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28027767/t1-mapping-cardiovascular-magnetic-resonance-imaging-to-detect-myocarditis-impact-of-slice-orientation-on-the-diagnostic-performance
#16
Sebastian Bohnen, Ulf K Radunski, Gunnar K Lund, Enver Tahir, Maxim Avanesov, Christian Stehning, Bernhard Schnackenburg, Gerhard Adam, Stefan Blankenberg, Kai Muellerleile
BACKGROUND: T1 mapping is a promising diagnostic tool to improve the diagnostic accuracy of cardiovascular magnetic resonance (CMR) in patients with suspected myocarditis. However, there are currently no data on the potential influence of slice orientation on the diagnostic performance of CMR. Thus, we compared the diagnostic performance of global myocardial T1 and extracellular volume (ECV) values to differentiate patients with myocarditis from healthy individuals between different slice orientations...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28017305/predicting-unsuccessful-electrical-cardioversion-for-acute-atrial-fibrillation-from-the-af-cvs-score
#17
Samuli Jaakkola, Gregory Y H Lip, Fausto Biancari, Ilpo Nuotio, Juha E K Hartikainen, Antti Ylitalo, K E Juhani Airaksinen
Electrical cardioversion (ECV) is the standard treatment for acute atrial fibrillation (AF), but identification of patients with increased risk of ECV failure or early AF recurrence is of importance for rational clinical decision-making. The objective of this study was to derive and validate a clinical risk stratification tool for identifying patients at high risk for unsuccessful outcome after ECV for acute AF. Data on 2,868 patients undergoing 5,713 ECVs of acute AF in 3 Finnish hospitals from 2003 through 2010 (the FinCV study data) were included in the analysis...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28008358/impact-of-microvascular-obstruction-on-semiautomated-techniques-for-quantifying-acute-and-chronic-myocardial-infarction-by-cardiovascular-magnetic-resonance
#18
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Shane Weinmann, Alex Sirker, Anna S Herrey, Charlotte Manisty, James C Moon, Derek J Hausenloy
AIMS: The four most promising semiautomated techniques (5-SD, 6-SD, Otsu and the full width half maximum (FWHM)) were compared in paired acute and follow-up cardiovascular magnetic resonance (CMR), taking into account the impact of microvascular obstruction (MVO) and using automated extracellular volume fraction (ECV) maps for reference. Furthermore, their performances on the acute scan were compared against manual myocardial infarct (MI) size to predict adverse left ventricular (LV) remodelling (≥20% increase in end-diastolic volume)...
2016: Open Heart
https://www.readbyqxmd.com/read/28003137/a-feasible-and-automatic-free-tool-for-t1-and-ecv-mapping
#19
Luisa Altabella, Cristian Borrazzo, Marco Carnì, Nicola Galea, Marco Francone, Andrea Fiorelli, Elisabetta Di Castro, Carlo Catalano, Iacopo Carbone
PURPOSE: Cardiac magnetic resonance (CMR) is a useful non-invasive tool for characterizing tissues and detecting myocardial fibrosis and edema. Estimation of extracellular volume fraction (ECV) using T1 sequences is emerging as an accurate biomarker in cardiac diseases associated with diffuse fibrosis. In this study, automatic software for T1 and ECV map generation consisting of an executable file was developed and validated using phantom and human data. METHODS: T1 mapping was performed in phantoms and 30 subjects (22 patients and 8 healthy subjects) on a 1...
January 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/27993845/establishing-genotypic-cutoff-values-to-measure-antimicrobial-resistance-in-salmonella
#20
Gregory H Tyson, Shaohua Zhao, Cong Li, Sherry Ayers, Jonathan L Sabo, Claudia Lam, Ron A Miller, Patrick F McDermott
Whole-genome sequencing (WGS) has transformed our understanding of antimicrobial resistance, helping us to better identify and track the genetic mechanisms underlying phenotypic resistance. Previous studies have demonstrated high correlations between phenotypic resistance and the presence of known resistance determinants. However, there has never been a large-scale assessment of how well resistance genotypes correspond to specific minimum inhibitory concentrations (MICs). We performed antimicrobial susceptibility testing and WGS of 1,738 nontyphoidal Salmonella strains to correlate over 20,000 MICs with resistance determinants...
December 19, 2016: Antimicrobial Agents and Chemotherapy
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