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https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#1
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29781568/diastolic-dysfunction-is-associated-with-exercise-impairment-in-patients-with-sickle-cell-anemia
#2
Tarek Alsaied, Omar Niss, Adam W Powell, Robert J Fleck, James F Cnota, Clifford Chin, Punam Malik, Charles T Quinn, Michael D Taylor
BACKGROUND: Left ventricular diastolic dysfunction (DD) is an independent risk factor for mortality in sickle cell anemia (SCA) and is associated with increased extracellular volume (ECV) on cardiac MRI (CMR). Exercise impairment is common in SCA, but its causes and prognostic value are not well understood. OBJECTIVE: To study the effects of DD and ECV on cardiopulmonary exercise test (CPET) in patients with SCA. METHODS AND RESULTS: As part of a prospective study to characterize the cardiomyopathy of SCA (NCT02410811), 20 children and adults with SCA underwent CMR, echocardiography, and cycle ergometer CPET (age range 8-43 years)...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29739912/early-cerebral-vein-after-endovascular-ischemic-stroke-treatment-predicts-symptomatic-reperfusion-hemorrhage
#3
Samuel C D Cartmell, Robyn L Ball, Rajani Kaimal, Nicholas A Telischak, Michael P Marks, Huy M Do, Robert L Dodd, Gregory W Albers, Maarten G Lansberg, Jeremy J Heit
BACKGROUND AND PURPOSE: Parenchymal hemorrhage (PH) after endovascular mechanical thrombectomy in acute ischemic stroke leads to worse outcomes. Better clinical and imaging biomarkers of symptomatic reperfusion PH are needed to identify patients at risk. We identified clinical and imaging predictors of reperfusion PH after endovascular mechanical thrombectomy with attention to early cerebral veins (ECVs) on postreperfusion digital subtraction angiography. METHODS: We performed a retrospective cohort study of consecutive acute ischemic stroke patients undergoing endovascular mechanical thrombectomy at our neurovascular referral center...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29728953/electrocardiography-based-prediction-of-hypertrophy-pattern-and-fibrosis-amount-in-hypertrophic-cardiomyopathy-comparative-study-with-cardiac-magnetic-resonance-imaging
#4
Chul Hwan Park, Hyemoon Chung, Yoonjung Kim, Jong-Youn Kim, Pil-Ki Min, Kyung-A Lee, Young Won Yoon, Tae Hoon Kim, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Although, cardiac magnetic resonance imaging (CMR) is a gold standard for risk stratification of hypertrophic cardiomyopathy (HCM), is limited in some situations. We sought to evaluate the predictive power of quantitative electrocardiography in assessing hypertrophy pattern and fibrosis in HCM. Eighty-eight patients with HCM were studied. Voltage of R-S-T waves, number of fragmented QRS (fQRS) complexes, and T wave morphology were measured by 12-lead electrocardiography. Sixteen segmental thickness, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV), and T2, left ventricular (LV) mass and %LGE were measured by CMR...
May 4, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29714035/myocardial-extracellular-volume-quantified-by-magnetic-resonance-is-increased-in-cirrhosis-and-related-to-poor-outcome
#5
Signe Wiese, Jens Hove, Silje Mo, Rajeshwar P Mookerjee, Claus L Petersen, Marianne K Vester-Andersen, Naja D Mygind, Jens P Goetze, Andreas Kjaer, Flemming Bendtsen, Søren Møller
BACKGROUND & AIMS: The underlying pathogenesis of cirrhotic cardiomyopathy is unclear. Structural myocardial changes including diffuse fibrosis may be involved and can be accurately assessed by cardiac MRI (CMR) with quantification of the extracellular volume (ECV).This is the first application of this technique in patients with cirrhosis. We aimed to investigate the presence of diffuse myocardial fibrosis and to determine the relation to disease severity, cardiac function, and outcome...
April 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29702304/the-factor-structure-of-the-short-form-of-the-wisconsin-schizotypy-scales
#6
Antonio Preti, Rosanna Scanu, Tamara Muratore, Giustino Claudetti, Andrea Cao, Rossana Scerman, Marta Carrus, Carlotta Cadoni, Antonio Manca, Giovanni D'Errico, Augusto Contu, Donatella R Petretto
The Chapman psychosis-proneness scales-also known as Wisconsin schizotypy scales (WSS)-are among the most used tools to measure schizotypy. The factor structure of the short-form WSS was investigated in a mixed sample of patients with chronic mental disorders and of healthy subjects from the general population. One hundred patients with a chronic mental disorder were enrolled over a 6-month period. For each patient, two controls of same sex and similar age (±5 years) were enrolled; 131 accepted to take part in the study...
April 19, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29681243/association-between-myocardial-extracellular-volume-and-strain-analysis-through-cardiovascular-magnetic-resonance-with-histological-myocardial-fibrosis-in-patients-awaiting-heart-transplantation
#7
Yue Cui, Yukun Cao, Jing Song, Nianguo Dong, Xiangchuang Kong, Jing Wang, Yating Yuan, Xiaolei Zhu, Xu Yan, Andreas Greiser, Heshui Shi, Ping Han
BACKGROUND: Cardiovascular magnetic resonance (CMR)-derived extracellular volume (ECV) and tissue tracking strain analyses are proposed as non-invasive methods for quantifying myocardial fibrosis and deformation. This study sought (1) to histologically validate myocardial ECV against the collagen volume fraction (CVF) measured from tissue samples of patients undergoing heart transplantation and (2) to detect the correlations between myocardial systolic strain and the myocardial ECV and histological CVF in patients undergoing heart transplantation...
April 23, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29679446/salt-is-not-only-sodium-how-extracellular-fluid-volume-homeostasis-depends-on-chloride-recovery-by-the-kidneys
#8
EDITORIAL
Boye L Jensen
The Acta Physiologica Prize winners Grill et al.1 address a fundamental issue in renal and circulatory physiology, namely how the kidneys accomplish maintenance of extracellular fluid volume (ECV) by conservation of the freely filtered solutes Na+ and Cl-. In an elegant comprehensive investigation in mice, they show that the chloride channel ClC-K2 is necessary for ECV homeostasis. The study sheds light on how the human kidneys regain 20 moles or 0.5 kg of chloride ions per day. Maintenance of ECV is essential for effective circulating volume, constant perfusion pressure and adequate organ perfusion...
April 20, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29657146/absence-of-fibrosis-and-inflammation-by-cardiac-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients-with-low-to-moderate-disease-activity
#9
William Bradham, Michelle J Ormseth, Comfort Elumogo, Srikanth Palanisamy, Chia-Ying Liu, Mark A Lawson, Jonathan H Soslow, Nadine Kawel-Boehm, David A Bluemke, C Michael Stein
OBJECTIVE: The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, function, and fibrosis. METHODS: We performed 1.5-T cMRI in 59 patients with RA and 56 controls frequency-matched for age, race, and sex, and compared cMRI indices of structure, function, and fibrosis [late gadolinium enhancement (LGE), native T1 mapping, and extracellular volume (ECV)] using Mann-Whitney U tests and linear regression, adjusting for age, race, and sex...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29628507/%C3%AE-np73-enhances-hif-1%C3%AE-protein-stability-through-repression-of-the-ecv-complex
#10
Marina Stantic, Johanna Wolfsberger, Habib A M Sakil, Margareta T Wilhelm
Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows for metabolic adaptations. HIF-1α protein levels are tightly regulated through ubiquitin-mediated proteosomal degradation; however, high levels of HIF-1α is a common feature in many solid tumors and is thought to enhance cancer cell proliferation, migration, and survival. Here, we report that the oncogenic p73 isoform, ∆Np73, increases HIF-1α protein stability...
April 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29617988/myocardial-native-t1-and-extracellular-volume-with-healthy-ageing-and-gender
#11
Stefania Rosmini, Heerajnarain Bulluck, Gabriella Captur, Thomas A Treibel, Amna Abdel-Gadir, Anish N Bhuva, Veronica Culotta, Ahmed Merghani, Marianna Fontana, Viviana Maestrini, Anna S Herrey, Kelvin Chow, Richard B Thompson, Stefan K Piechnik, Peter Kellman, Charlotte Manisty, James C Moon
Aims: To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges. Methods and results: Ninety-four healthy volunteers with no a history or symptoms of cardiovascular disease or diabetes underwent cardiovascular magnetic resonance at 1.5 T. Mid-ventricular short axis native and post-contrast T1 maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), MOdified Look-Locker Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] and saturation recovery single-shot acquisition (SASHA) were acquired and ECV by these three techniques were derived for the mid anteroseptum...
March 30, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29615835/the-effect-of-electronic-cigarette-and-tobacco-smoke-exposure-on-copd-bronchial-epithelial-cell-inflammatory-responses
#12
Andrew Higham, Declan Bostock, George Booth, Josiah V Dungwa, Dave Singh
Background: Electronic cigarettes (e-cigs) are used to help smoking cessation. However, these devices contain harmful chemicals, and there are safety concerns. We have investigated the effects of e-cigs on the inflammatory response and viability of COPD bronchial epithelial cells (BECs). Methods: BECs from COPD patients and controls were exposed to e-cig vapor extract (ECVE) and the levels of interleukin (IL)-6, C-X-C motif ligand 8 (CXCL8), and lactate dehydrogenase release were measured...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29613847/myocardial-extracellular-volume-fraction-and-change-in-hematocrit-level-mr-evaluation-by-using-t1-mapping-in-an-experimental-model-of-anemia
#13
Pan Ki Kim, Yoo Jin Hong, Hajime Sakuma, Ashish Chawla, Jeffrey Kihyun Park, Chul Hwan Park, Donghyun Hong, Kyunghwa Han, Ji Yeon Lee, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Byoung Wook Choi
Purpose To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material-enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study...
April 3, 2018: Radiology
https://www.readbyqxmd.com/read/29609898/real-time-pathophysiologic-correlates-of-left-atrial-appendage-thrombus-in-patients-who-underwent-transesophageal-guided-electrical-cardioversion-for-atrial-fibrillation
#14
Rowlens M Melduni, Bernard J Gersh, Waldemar E Wysokinski, Naser M Ammash, Paul A Friedman, David O Hodge, Krishnaswamy Chandrasekaran, Jae K Oh, Hon-Chi Lee
Although current guidelines advocate using the CHA2 DS2 -VASc score to assess the risk of stroke in patients with atrial fibrillation (AF), compared with transesophageal echocardiography (TEE), its ability to predict left atrial appendage thrombus (LAAT) is limited. We studied 3,324 consecutive patients with sustained AF from our prospective registry of patients who underwent first-time TEE-guided electrical cardioversion (ECV) from May 2000 through March 2012. The association of CHA2 DS2 -VASc score or TEE risk factors with the occurrence of LAAT was analyzed...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29605901/right-ventricular-septomarginal-trabeculation-hypertrophy-is-associated-with-disease-severity-in-patients-with-pulmonary-arterial-hypertension
#15
Yang Dong, Jiayu Sun, Dan Yang, Juan He, Wei Cheng, Ke Wan, Hong Liu, Andreas Greiser, Xiaoyue Zhou, Yuchi Han, Yucheng Chen
To characterize the morphological change in the right ventricle (RV) of patients with pulmonary artery hypertension (PAH) and further explore the correlation between septomarginal trabeculation (SMT) and right ventricular (RV) function, myocardial fibrosis, and exercise capacity in patients with PAH. Sixty untreated PAH patients were prospectively included from May 2016 to April 2017. All patients underwent comprehensive clinical evaluation and cardiac magnetic resonance (CMR). The area and diameter of the basal segment of SMT, and the mass of SMT were measured on cine SSFP images...
March 31, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29601139/myocardial-fibrosis-evaluated-by-diffusion-weighted-imaging-and-its-relationship-to-3d-contractile-function-in-patients-with-hypertrophic-cardiomyopathy
#16
Rui Wu, Dong-Aolei An, Ruo-Yang Shi, Bing-Hua Chen, Meng Jiang, Andrew Bacyinski, Tong-Tong Han, Jiani Hu, Jian-Rong Xu, Lian-Ming Wu
BACKGROUND: Previous studies have shown that diffusion-weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy. PURPOSE: To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM). STUDY TYPE: Prospective. POPULATION: A total of 45 HCM patients and 20 controls...
March 30, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29600485/diffuse-fibrosis-is-common-in-the-left-but-not-in-the-right-ventricle-in-patients-with-transposition-of-the-great-arteries-late-after-atrial-switch-operation
#17
Nerejda Shehu, Christian Meierhofer, Daniel Messroghli, Naira Mkrtchyan, Stefan Martinoff, Peter Ewert, Heiko Stern
In adult patients with transposition of the great arteries (TGA) late after atrial switch operation (AtSO), each of the ventricles is faced with a profoundly different pressure regimen from the one they are meant to support in normal conditions. The extent of diffuse fibrosis of the right ventricle (RV) and left ventricle (LV) in these patients remains incompletely investigated. Aim of this study was to quantify the degree of fibrosis of the unloaded LV and of the overloaded RV by determining the myocardial extracellular volume (ECV) with non-invasive techniques as T1 mapping...
March 29, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29592837/a-proposal-of-antifungal-epidemiological-cut-off-values-against-histoplasma-capsulatum-var-capsulatum-based-on-the-susceptibility-of-isolates-from-hiv-infected-patients-with-disseminated-histoplasmosis-in-northeastern-brazil
#18
Raimunda Sâmia Nogueira Brilhante, Glaucia Morgana de Melo Guedes, Maria Lucilene Queiroz da Silva, Débora Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
Epidemiological cutoff values (ECV) have been used as a tool to detect the acquisition of resistance mechanisms to antifungal drugs. In this context, the objective of this study was to determine the epidemiological cutoff values for classic antifungals against Histoplasma capsulatum var. capsulatum isolates from HIV-infected patients with the diagnosis of disseminated histoplasmosis. Initially, the minimum inhibitory concentrations (MIC) for amphotericin B, itraconazole, fluconazole, voriconazole and caspofungin against 138 isolates of H...
March 25, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29588504/saturation-recovery-myocardial-t-1-mapping-during-systole-accurate-and-robust-quantification-in-the-presence-of-arrhythmia
#19
Nadja M Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R Schad, Sebastian Weingärtner, Frank G Zöllner
Myocardial T1 -mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T1 -mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T1 -mapping method was modified to enable imaging during systole...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29569353/cardioversion-of-persistent-atrial-fibrillation-is-associated-with-a-24-hour-relapse-gap-observations-from-prolonged-postcardioversion-rhythm-monitoring
#20
Bob Weijs, Ione Limantoro, Tammo Delhaas, Cees B de Vos, Yuri Blaauw, Richard P M Houben, Sander Verheule, Ronny Pisters, Harry J G M Crijns
BACKGROUND: Many recurrences occur after electrical cardioversion (ECV) of atrial fibrillation (AF). Assessment of extent of remodeling and continuous prolonged rhythm monitoring might reveal actionable recurrence mechanisms. HYPOTHESIS: After ECV of AF specific patterns of arrhythmia recurrence can be distinguished. METHODS: All patients who underwent successful ECV due to persistent AF were included. Tissue velocity echocardiography during AF was performed before ECV to study atrial fibrillatory cycle length and fibrillatory velocity...
March 22, 2018: Clinical Cardiology
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