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https://www.readbyqxmd.com/read/28077133/t1-and-t2-mapping-for-evaluation-of-myocardial-involvement-in-patients-with-anca-associated-vasculitides
#1
Simon Greulich, Agnes Mayr, Daniel Kitterer, Joerg Latus, Joerg Henes, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting with no or nonspecific symptoms, normal ECG, and preserved left-ventricular ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due to myocardial involvement, a reliable diagnostic tool is warranted. In contrast to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic processes, recent mapping techniques are able to detect even subtle, diffuse inflammatory or fibrotic processes...
January 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28069273/does-antiarrhythmic-drugs-premedication-improve-electrical-cardioversion-success-in-persistent-atrial-fibrillation
#2
Elisabetta Toso, Mario Iannaccone, Domenico Caponi, Francesco Rotondi, Antonio Santoro, Cristina Gallo, Marco Scaglione, Fiorenzo Gaita
AIMS: Aim of this study is to evaluate the impact of antiarrhythmic drugs (AADs) administration for at least one month before ECV on the acute and long term success rate of the procedure. METHODS: 1313 consecutive persistent AF patients were enrolled in 3 different centers (Turin, Asti and Avellino): 692 patients received AADs before and after ECV (group A), 621 patients were treated only after the procedure, at discharge (group B). Primary end point was the restoration and maintenance of sinus rhythm acutely and at a long-term follow up...
December 29, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28058227/magnetic-resonance-imaging-of-the-transplanted-pediatric-heart-as-a-potential-predictor-of-rejection
#3
Steven C Greenway, Frederic Dallaire, Paul F Kantor, Anne I Dipchand, Rajiv R Chaturvedi, Monali Warade, Eugenie Riesenkampff, Shi-Joon Yoo, Lars Grosse-Wortmann
AIM: To evaluate cardiac magnetic resonance imaging (CMR) as a non-invasive tool to detect acute cellular rejection (ACR) in children after heart transplant (HT). METHODS: Thirty pediatric HT recipients underwent CMR at the time of surveillance endomyocardial biopsy (EMB) and results were compared to 14 non-transplant controls. Biventricular volumes, ejection fractions (EFs), T2-weighted signal intensities, native T1 times, extracellular volumes (ECVs) and presence of late gadolinium enhancement (LGE) were compared between patients and controls and between patients with International Society of Heart and Lung Transplantation (ISHLT) grade ≥ 2R rejection and those with grade 0/1R...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28042730/sex-age-and-time-to-cardioversion-risk-factors-for-cardioversion-of-acute-atrial-fibrillation-from-the-fincv-study
#4
Aissa Bah, Ilpo Nuotio, Toni Grönberg, Antti Ylitalo, K E Juhani Airaksinen, Juha E K Hartikainen
BACKGROUND: Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in anticoagulant-naive patients with acute AF. METHODS AND RESULTS: The primary outcome was a TEC within 30 days following ECV. Patients were divided into three age groups and time to cardioversion into <12 h and ≥12 h in 4715 ECVs...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/28040512/extracellular-vesicles-of-the-blood-brain-barrier-role-in-the-hiv-1-associated-amyloid-beta-pathology
#5
Ibolya E András, Ana Leda, Marta Garcia Contreras, Luc Bertrand, Minseon Park, Marta Skowronska, Michal Toborek
HIV-infected brains are characterized by increased amyloid beta (Aβ) deposition. It is believed that the blood-brain barrier (BBB) is critical for Aβ homeostasis and contributes to Aβ accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in Aβ pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced Aβ pathology in the brain...
December 29, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28027767/t1-mapping-cardiovascular-magnetic-resonance-imaging-to-detect-myocarditis-impact-of-slice-orientation-on-the-diagnostic-performance
#6
Sebastian Bohnen, Ulf K Radunski, Gunnar K Lund, Enver Tahir, Maxim Avanesov, Christian Stehning, Bernhard Schnackenburg, Gerhard Adam, Stefan Blankenberg, Kai Muellerleile
BACKGROUND: T1 mapping is a promising diagnostic tool to improve the diagnostic accuracy of cardiovascular magnetic resonance (CMR) in patients with suspected myocarditis. However, there are currently no data on the potential influence of slice orientation on the diagnostic performance of CMR. Thus, we compared the diagnostic performance of global myocardial T1 and extracellular volume (ECV) values to differentiate patients with myocarditis from healthy individuals between different slice orientations...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28017305/predicting-unsuccessful-electrical-cardioversion-for-acute-atrial-fibrillation-from-the-af-cvs-score
#7
Samuli Jaakkola, Gregory Y H Lip, Fausto Biancari, Ilpo Nuotio, Juha E K Hartikainen, Antti Ylitalo, K E Juhani Airaksinen
Electrical cardioversion (ECV) is the standard treatment for acute atrial fibrillation (AF), but identification of patients with increased risk of ECV failure or early AF recurrence is of importance for rational clinical decision-making. The objective of this study was to derive and validate a clinical risk stratification tool for identifying patients at high risk for unsuccessful outcome after ECV for acute AF. Data on 2,868 patients undergoing 5,713 ECVs of acute AF in 3 Finnish hospitals from 2003 through 2010 (the FinCV study data) were included in the analysis...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28008358/impact-of-microvascular-obstruction-on-semiautomated-techniques-for-quantifying-acute-and-chronic-myocardial-infarction-by-cardiovascular-magnetic-resonance
#8
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Shane Weinmann, Alex Sirker, Anna S Herrey, Charlotte Manisty, James C Moon, Derek J Hausenloy
AIMS: The four most promising semiautomated techniques (5-SD, 6-SD, Otsu and the full width half maximum (FWHM)) were compared in paired acute and follow-up cardiovascular magnetic resonance (CMR), taking into account the impact of microvascular obstruction (MVO) and using automated extracellular volume fraction (ECV) maps for reference. Furthermore, their performances on the acute scan were compared against manual myocardial infarct (MI) size to predict adverse left ventricular (LV) remodelling (≥20% increase in end-diastolic volume)...
2016: Open Heart
https://www.readbyqxmd.com/read/28003137/a-feasible-and-automatic-free-tool-for-t1-and-ecv-mapping
#9
Luisa Altabella, Cristian Borrazzo, Marco Carnì, Nicola Galea, Marco Francone, Andrea Fiorelli, Elisabetta Di Castro, Carlo Catalano, Iacopo Carbone
PURPOSE: Cardiac magnetic resonance (CMR) is a useful non-invasive tool for characterizing tissues and detecting myocardial fibrosis and edema. Estimation of extracellular volume fraction (ECV) using T1 sequences is emerging as an accurate biomarker in cardiac diseases associated with diffuse fibrosis. In this study, automatic software for T1 and ECV map generation consisting of an executable file was developed and validated using phantom and human data. METHODS: T1 mapping was performed in phantoms and 30 subjects (22 patients and 8 healthy subjects) on a 1...
December 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27993845/establishing-genotypic-cutoff-values-to-measure-antimicrobial-resistance-in-salmonella
#10
Gregory H Tyson, Shaohua Zhao, Cong Li, Sherry Ayers, Jonathan L Sabo, Claudia Lam, Ron A Miller, Patrick F McDermott
Whole-genome sequencing (WGS) has transformed our understanding of antimicrobial resistance, helping us to better identify and track the genetic mechanisms underlying phenotypic resistance. Previous studies have demonstrated high correlations between phenotypic resistance and the presence of known resistance determinants. However, there has never been a large-scale assessment of how well resistance genotypes correspond to specific minimum inhibitory concentrations (MICs). We performed antimicrobial susceptibility testing and WGS of 1,738 nontyphoidal Salmonella strains to correlate over 20,000 MICs with resistance determinants...
December 19, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27992875/calf-resistivity-values-in-chronic-kidney-disease-in-a-caucasian-population
#11
Eric Seibert, Stephan G Müller, Johanna Pattmöller, Peter Kotanko, Fansan Zhu, Nathan W Levin, Roman Fiedler, Martin K Kuhlmann, Matthias Girndt
BACKGROUND: Continuous intradialytic calf bioimpedance spectroscopy (cBIS) allows assessment of changes in calf extracellular fluid volume (ECV) to determine dry weight (DW) in hemodialysis patients. During dialysis, calf ECV decreases until excessive ECV has been removed and normalized resistivity ρN,5 rises to values comparable to those of a normal population (cBIS-DW). It is not clear whether chronic kidney disease (CKD) itself influences ρN,5 and whether normal values depend on race and ethnicity...
December 20, 2016: Nephron
https://www.readbyqxmd.com/read/27974408/interstitial-fibrosis-functional-status-and-outcomes-in-heart-failure-with-preserved-ejection-fraction-insights-from-a-prospective-cardiac-magnetic-resonance-imaging-study
#12
Franz Duca, Andreas A Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L Schwaiger, Beatrice A Marzluf, Diana Bonderman, Julia Mascherbauer
BACKGROUND: Myocardial extracellular volume (ECV) accumulation is one of the key pathophysiologic features of heart failure with preserved ejection fraction (HFpEF). Our aims were to (1) measure ECV by cardiac magnetic resonance T1 mapping using the modified Look-Locker inversion recovery (MOLLI) sequence, (2) validate MOLLI-ECV against histology, and (3) investigate the relationship between MOLLI-ECV and prognosis in HFpEF. METHODS AND RESULTS: One-hundred seventeen consecutive HFpEF patients underwent cardiac magnetic resonance imaging, coronary angiography, and invasive hemodynamic assessments at baseline...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27955698/histologic-validation-of-myocardial-fibrosis-measured-by-t1-mapping-a-systematic-review-and-meta-analysis
#13
Kai-Yue Diao, Zhi-Gang Yang, Hua-Yan Xu, Xi Liu, Qin Zhang, Ke Shi, Li Jiang, Lin-Jun Xie, Ling-Yi Wen, Ying-Kun Guo
BACKGROUND: Myocardial fibrosis is being increasingly recognised as a common final pathway of a wide range of diseases. Thus, the development of an accurate and convenient method to evaluate myocardial fibrosis is of major importance. Although T1 mapping is a potential alternative for myocardial biopsy, validation studies are limited to small numbers and vary regarding technical facets, and include only a restricted number of disease. A systematic review and meta-analysis was conducted to objectively and comprehensively evaluate the performance of T1 mapping on the quantification of myocardial fibrosis using cardiovascular magnetic resonance (CMR)...
December 12, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27931223/pattern-and-prognostic-value-of-cardiac-involvement-in-patients-with-late-onset-pompe-disease-a-comprehensive-cardiovascular-magnetic-resonance-approach
#14
Matthias Boentert, Anca Florian, Bianca Dräger, Peter Young, Ali Yilmaz
BACKGROUND: Pompe disease is an autosomal recessive disorder caused by deficiency of the lysosomal α-1,4-glucosidase leading to accumulation of glycogen in target tissues with progressive organ failure. While the early infantile-onset form is characterized by early severe hypertrophic cardiomyopathy with cardiac and respiratory failure, clinically relevant cardiomyopathy seems to be uncommon in patients with late-onset Pompe disease, and the prevalence and nature of myocardial abnormalities are still to be clarified...
December 7, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27930530/a-randomized-trial-of-remifentanil-for-analgesia-in-external-cephalic-version-for-breech-presentation
#15
Xiaohua Liu, Aiqin Xue
BACKGROUND: Although external cephalic version (ECV) can be effective for correcting the fetus in a cephalic presentation, it may be painful for the mother. This study aimed to evaluate the efficacy and safety of remifentanil for pain relief during ECV in China. METHODS: In all, 152 Chinese parturients with singleton breech presentation were randomly divided into 2 groups, each with 76 patients. All 152 patients were assigned to receive either remifentanil (infused at 0...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27923261/value-of-cardiac-t1-mapping-and-ecv-quantification-in-duchenne-muscular-dystrophy-dmd-case%C3%A2-report-typical-imaging-findings-and-review%C3%A2-of-the-literature
#16
Fritz Christian Roller, Sebastian Harth, Gabriele Anja Krombach
No abstract text is available yet for this article.
January 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/27899132/cardiac-t1-mapping-and-extracellular-volume-ecv-in-clinical-practice-a-comprehensive-review
#17
REVIEW
Philip Haaf, Pankaj Garg, Daniel R Messroghli, David A Broadbent, John P Greenwood, Sven Plein
Cardiovascular Magnetic Resonance is increasingly used to differentiate the aetiology of cardiomyopathies. Late Gadolinium Enhancement (LGE) is the reference standard for non-invasive imaging of myocardial scar and focal fibrosis and is valuable in the differential diagnosis of ischaemic versus non-ischaemic cardiomyopathy. Diffuse fibrosis may go undetected on LGE imaging. Tissue characterisation with parametric mapping methods has the potential to detect and quantify both focal and diffuse alterations in myocardial structure not assessable by LGE...
November 30, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27878700/performance-of-native-and-contrast-enhanced-t1-mapping-to-detect-myocardial-damage-in-patients-with-suspected-myocarditis-a-head-to-head-comparison-of-different-cardiovascular-magnetic-resonance-techniques
#18
Jonathan Nadjiri, Hanna Nieberler, Eva Hendrich, Andreas Greiser, Albrecht Will, Stefan Martinoff, Martin Hadamitzky
Myocardial T1 mapping is a novel technique that has proven to be superior to standard imaging for differentiation between healthy individuals in acute myocarditis. Aim of this study was comparison of T1 mapping with a clinical biomarker. We retrospectively investigated 171 patients undergoing cardiovascular magnetic resonance (CMR) examination with suspected myocarditis by performing native and contrast enhanced T1-mapping. Additionally, T2w and T1w images and late gadolinium enhancement sequences (LGE) were utilized for myocardial evaluation; Lake Louise Criteria comprise T1w, T2w and LGE imaging in a score...
November 23, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27861208/left-ventricular-myocardial-fibrosis-atrophy-and-impaired-contractility-in-patients-with-pulmonary-arterial-hypertension-and-a-preserved-left-ventricular-function-a-cardiac-magnetic-resonance-study
#19
Rami Homsi, Julian A Luetkens, Dirk Skowasch, Carmen Pizarro, Alois M Sprinkart, Juergen Gieseke, Julia Meyer Zur Heide Gen Meyer-Arend, Hans H Schild, Claas P Naehle
PURPOSE: Using a cardiac magnetic resonance (CMR) approach we investigated left ventricular (LV) myocardial changes associated with pulmonary arterial hypertension (PAH) by strain analysis and mapping techniques. MATERIALS AND METHODS: Seventeen patients with PAH (9 men; mean age, 64.2±13.6 y) and 20 controls (10 men, 63.2±10.5 y) were examined using CMR at 1.5 T. Native LV T1-relaxation times (T1) and extracellular volume fraction (ECV) were assessed using a MOLLI sequence, T2-relaxation times (T2) by means of a gradient spin-echo sequence, and LV longitudinal strain (LVS) and right ventricular (RV) longitudinal strain (RVS) by means of CMR feature tracking...
January 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27855705/myocardial-t1-mapping-at-3t-using-saturation-recovery-reference-values-precision-and-comparison-with-molli
#20
Sebastian Weingärtner, Nadja M Meßner, Johannes Budjan, Dirk Loßnitzer, Uwe Mattler, Theano Papavassiliu, Frank G Zöllner, Lothar R Schad
BACKGROUND: Myocardial T1-mapping recently emerged as a promising quantitative method for non-invasive tissue characterization in numerous cardiomyopathies. Commonly performed with an inversion-recovery (IR) magnetization preparation at 1.5T, the application at 3T has gained due to increased quantification precision. Alternatively, saturation-recovery (SR) T1-mapping has recently been introduced at 1.5T for improved accuracy. Thus, the purpose of this study is to investigate the robustness and precision of SR T1-mapping at 3T and to establish accurate reference values for native T1-times and extracellular volume fraction (ECV) of healthy myocardium...
November 18, 2016: Journal of Cardiovascular Magnetic Resonance
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