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https://www.readbyqxmd.com/read/28918113/regulation-of-mitochondrial-bioenergetics-by-the-non-canonical-roles-of-mitochondrial-dynamics-proteins-in-the-heart
#1
REVIEW
Wang Wang, Celia Fernandez-Sanz, Shey-Shing Sheu
Recent advancement in mitochondrial research has significantly extended our knowledge on the role and regulation of mitochondria in health and disease. One important breakthrough is the delineation of how mitochondrial morphological changes, termed mitochondrial dynamics, are coupled to the bioenergetics and signaling functions of mitochondria. In general, it is believed that fusion leads to an increased mitochondrial respiration efficiency and resistance to stress-induced dysfunction while fission does the contrary...
September 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28915963/hepcidin-and-metallothioneins-as-molecular-base-for-sex-dependent-differences-in-clinical-course-of-experimental-autoimmune-encephalomyelitis-in-chronic-iron-overload
#2
Božena Ćurko-Cofek, Tanja Grubić Kezele, Vesna Barac-Latas
Multiple sclerosis is a chronic demyelinating disease of the central nervous system characterised by inflammatory and degenerative changes. It is considered that disease arises from the influence of environmental factors on genetically susceptible individuals. Recent researches, using magnetic resonance imaging, connected iron deposits in different brain regions with demyelinating process in multiple sclerosis patients. Although iron is an essential trace element important for many biological functions it could be harmful because iron excess can induce the production of reactive oxygen species, development of oxidative stress and lipid peroxidation which leads to demyelination...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28912641/toll-like-receptor-2-a-novel-therapeutic-target-for-ischemic-white-matter-injury-and-oligodendrocyte-death
#3
REVIEW
Jun Young Choi, Byung Gon Kim
Despite paramount clinical significance of white matter stroke, there is a paucity of researches on the pathomechanism of ischemic white matter damage and accompanying oligodendrocyte (OL) death. Therefore, a large gap exists between clinical needs and laboratory researches in this disease entity. Recent works have started to elucidate cellular and molecular basis of white matter injury under ischemic stress. In this paper, we briefly introduce white matter stroke from a clinical point of view and review pathophysiology of ischemic white matter injury characterized by OL death and demyelination...
August 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28912115/system-wide-inpatient-portal%C3%A2-implementation-survey-of-health-care-team-perceptions
#4
Jennifer L Hefner, Cynthia J Sieck, Daniel M Walker, Timothy R Huerta, Ann Scheck McAlearney
BACKGROUND: Inpatient portals, a new type of patient portal tailored specifically to the hospital setting, can allow patients to access up-to-date health information and exchange secure communications with their care team. As such, inpatient portals present an opportunity for patients to increase engagement in their care during a time of acute crisis that emphasizes focus on a patient's health. While there is a large body of research on patient portals in the outpatient setting, questions are being raised specifically about inpatient portals, such as how they will be incorporated into the flow of patient care in hectic, stressed, team-based hospital settings...
September 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28900732/plant-stand-p-loop-ntpases-a-current-perspective-of-genome-distribution-evolution-and-function-plant-stand-p-loop-ntpases-genomic-organization-evolution-and-molecular-mechanism-models-contribute-broadly-to-plant-pathogen-defense
#5
REVIEW
Preeti Arya, Vishal Acharya
STAND P-loop NTPase is the common weapon used by plant and other organisms from all three kingdoms of life to defend themselves against pathogen invasion. The purpose of this study is to review comprehensively the latest finding of plant STAND P-loop NTPase related to their genomic distribution, evolution, and their mechanism of action. Earlier, the plant STAND P-loop NTPase known to be comprised of only NBS-LRRs/AP-ATPase/NB-ARC ATPase. However, recent finding suggests that genome of early green plants comprised of two types of STAND P-loop NTPases: (1) mammalian NACHT NTPases and (2) NBS-LRRs...
September 12, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28892625/platinum-binds-proteins-in-the-endoplasmic-reticulum-of-s-cerevisiae-and-induces-er-stress
#6
Rachael M Cunningham, Victoria J DeRose
Pt(II)-based anticancer drugs are widely used in the treatment of a variety of cancers, but their clinical efficacy is hindered by undesirable side effects and resistance. While much research has focused on Pt(II) drug interactions with DNA, there is increasing interest in proteins as alternative targets and contributors to cytotoxic and resistance mechanisms. Here we describe a chemical proteomic method for isolation and identification of cellular protein targets of platinum compounds using Pt(II) reagents that have been modified for participation in the 1,3 dipolar cycloaddition "click" reaction...
September 11, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28891950/impact-of-silicon-in-plant-biomass-production-focus-on-bast-fibres-hypotheses-and-perspectives
#7
REVIEW
Marie Luyckx, Jean-Francois Hausman, Stanley Lutts, Gea Guerriero
Silicon (Si) is an abundant element which, when supplied to plants, confers increased vigor and resistance to exogenous stresses, as well as enhanced stem mechanical strength. Plant species vary in their ability to take Si up and to accumulate it under the form of silicon dioxide (SiO₂) in their tissues: emblematic of this is the example of Poales, among which there is rice, a high Si accumulator. Monocots usually accumulate more Si than dicots; however, the impact that Si has on dicots, notably on economically important dicots, is a subject requiring further study and scientific efforts...
September 9, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28889049/the-potential-impact-of-biochemical-mediators-on-telomere-attrition-in-major-depressive-disorder-and-implications-for-future-study-designs-a-narrative-review
#8
REVIEW
Andrei Manoliu, Oliver G Bosch, Janis Brakowski, Annette B Brühl, Erich Seifritz
BACKGROUND: Major depressive disorder (MDD) has been proposed to represent a "disease of premature aging", which is associated with certain biomarkers of cellular ageing and numerous other age-related diseases. Over the last decade, telomere length (TL) arose as a surrogate for cellular aging. Recent data suggests that TL might be reduced in patients with MDD, however, results are still inconclusive. This might be explained by the lack of assessment of potential biochemical mediators that are directly associated with telomere shortening and frequently observed in patients with MDD...
August 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28882157/symptom-management-in-complex-post-traumatic-stress-disorder-icd-11-view-and-experience-of-patients-and-their-relatives-a-mixed-methods-approach-research-proposal
#9
Manuel P Stadtmann, Andreas Maercker, Jochen Binder, Wilfried Schnepp
OBJECTIVE: Using the framework of IDC-11, complex post-traumatic stress disorder will be diagnosed using the core criteria of a post-traumatic stress disorder and the presence of at least one symptom from the following three domains: symptoms of emotional dysregulation, negative self-concept, and problems in interpersonal relationships. In the literature, these symptoms are discussed as a common reason for seeking treatment. The symptoms can influence and impair the quality of life. This article describes a mixed methods study with a sequential exploratory design...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28881851/the-involvement-of-darpp-32-in-the-pathophysiology-of-schizophrenia
#10
REVIEW
Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
Schizophrenia is one of the most devastating heterogeneous psychiatric disorders. The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia based on neurochemical evidences of elevated brain striatal dopamine synthesis capacity and increased dopamine release in response to stress. Dopamine and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000 (DARPP-32) is a cytosolic protein highly enriched in the medium spiny neurons of the neostriatum, considered as the most important integrator between the cortical input and the basal ganglia, and associated with motor control...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874589/dual-role-of-mitochondria-in-producing-melatonin-and-driving-gpcr-signaling-to-block-cytochrome-c-release
#11
Yalikun Suofu, Wei Li, Frédéric G Jean-Alphonse, Jiaoying Jia, Nicolas K Khattar, Jiatong Li, Sergei V Baranov, Daniela Leronni, Amanda C Mihalik, Yanqing He, Erika Cecon, Vanessa L Wehbi, JinHo Kim, Brianna E Heath, Oxana V Baranova, Xiaomin Wang, Matthew J Gable, Eric S Kretz, Giulietta Di Benedetto, Timothy R Lezon, Lisa M Ferrando, Timothy M Larkin, Mara Sullivan, Svitlana Yablonska, Jingjing Wang, M Beth Minnigh, Gérald Guillaumet, Franck Suzenet, R Mark Richardson, Samuel M Poloyac, Donna B Stolz, Ralf Jockers, Paula A Witt-Enderby, Diane L Carlisle, Jean-Pierre Vilardaga, Robert M Friedlander
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT1), its associated G protein, and β-arrestins are on and within neuronal mitochondria. We discovered that the ligand melatonin is exclusively synthesized in the mitochondrial matrix and released by the organelle activating the mitochondrial MT1 signal-transduction pathway inhibiting stress-mediated cytochrome c release and caspase activation...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28874054/critical-view-on-mesenchymal-stromal-cells-in-regenerative-medicine
#12
Agnieszka Langrzyk, Witold Norbert Nowak, Jacek Stepniewski, Agnieszka Jazwa, Urszula Florczyk, Alicja Jozkowicz, Jozef Dulak
The belief in the potency of stem cells has resulted in the medical applications of numerous cell types for organ repair, often with the low adherence to methodological stringency. Such uncritical enthusiasm is mainly presented in the approaches employing so-called mesenchymal stem cells (MSC), originally isolated from the bone marrow, then from other sources like adipose tissue or placenta, which are used for the treatment of numerous, unrelated condition. However, it should be stressed that such clinical applications of MSC were based on unsubstantiated belief that MSC can efficiently differentiate into multiple cell types, not only osteoblasts, chondrocytes and adipose cells...
September 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28871355/negative-mood-states-or-dysfunctional-cognitions-their-independent-and-interactional-effects-in-influencing-severity-of-gambling-among-chinese-problem-gamblers-in-hong-kong
#13
Daniel Fu Keung Wong, Xiao Yu Zhuang, Alun Jackson, Nicki Dowling, Herman Hay Ming Lo
Gambling-related cognitions and negative psychological states have been proposed as major factors in the initiation and maintenance of problem gambling (PG). While there are a substantial number of studies supporting the role of cognitive dysfunctions in the initiation and maintenance of PG, very few empirical studies have explored the specific role of negative psychological states in influencing PG behaviours. In addition, very few studies have examined the interaction effects of cognitive dysfunctions and negative psychological states in exerting influence on PG behaviours...
September 4, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28871267/how-the-depletion-in-mineral-major-elements-affects-grapevine-vitis-vinifera-l-primary-cell-wall
#14
REVIEW
Luís F Goulao, João C Fernandes, Sara Amâncio
The noteworthy fine remodeling that plant cell walls (CWs) undergo to adapt to developmental, physiological and environmental cues and the observation that its composition and dynamics differ between species represents an opportunity to couple crop species agronomic studies with research on CW modifications. Vitis vinifera is one of the most important crops from an economic point-of-view due to the high value of the fruit, predominantly for winemaking. The availability of some information related to this species' CWs allows researching its responses to imposed conditions that affect the plant's development...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28864709/early-interventions-for-the-prevention-of-post-traumatic-stress-symptoms-in-survivors-of-critical-illness-protocol-for-a-systematic-review
#15
Lindsey J Glaspey, Michael B Roberts, Anthony Mazzarelli, Stephen Trzeciak, Brian W Roberts
INTRODUCTION: Post-traumatic stress disorder (PTSD) is being increasingly reported among survivors of critical illness and injury. Previous work has demonstrated that PTSD reduces patient quality of life and ability to return to work, as well as increases healthcare costs. As such, identifying interventions aimed at preventing the development of critical illness-related PTSD could have an important public health impact. The objective of this systematic review is to collate the world's literature on early interventions aimed at preventing PTSD among survivors of critical illness...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28858985/beyond-solicitousness-a-comprehensive-review-on-informal-pain-related-social-support
#16
Sónia F Bernardes, Paula Forgeron, Karine Fournier, Jessica Reszel
Adults with chronic pain cite social support (SS) as an important resource. Research has mostly focused on general SS or pain-specific solicitousness, resulting in a limited understanding of the role of SS in pain experiences. Drawing on SS theoretical models, this review aimed to understand how pain-related SS has been conceptualized and measured and how its relationship with pain experiences has been investigated. Arksey and O´Malley's scoping review framework guided the study. A database search (2000-2015) was conducted in PsycINFO, CINAHL, MEDLINE, EMBASE using a combination of subject headings/keywords on pain and SS; 3864 citations were screened; 101 full texts were assessed for eligibility; references of 52 papers were hand searched...
August 3, 2017: Pain
https://www.readbyqxmd.com/read/28858536/serotonin-and-brain-function-a-tale-of-two-receptors
#17
R L Carhart-Harris, D J Nutt
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-HT1A and 5-HT2A receptors. We propose that passive coping (i.e. tolerating a source of stress) is mediated by postsynaptic 5-HT1AR signalling and characterised by stress moderation...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28827278/early-childhood-health-in-bielefeld-germany-babi-study-study-protocol-of-a-social-epidemiological-birth-cohort
#18
Jacob Spallek, Angelique Grosser, Chantal Höller-Holtrichter, Ina-Merle Doyle, Jürgen Breckenkamp, Oliver Razum
INTRODUCTION: The heterogeneity among the German population is increasing. Sociodemographic differentials (eg, in education and migrant status) have been associated with health disparities. Life course studies show that a considerable part of these disparities is determined by exposures during pregnancy and early childhood. The BaBi study was established in 2012 to investigate the production of health disparities from foetal life to childhood in the city of Bielefeld, Germany. METHODS AND ANALYSIS: Between 2013 and 2016, detailed information on socioeconomic characteristics, migration background, lifestyle factors, environmental factors, healthcare use, and health status of 995 newborns, including 24 twins, and their families was collected using standardised instruments...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28818262/brain-derived-neurotrophic-factor-mediates-cognitive-improvements-following-acute-exercise
#19
Andrew Borror
The mechanisms causing improved cognition following acute exercise are poorly understood. This article proposes that brain-derived neurotrophic factor (BDNF) is the main factor contributing to improved cognition following exercise. Additionally, it argues that cerebral blood flow (CBF) and oxidative stress explain the release of BDNF from cerebral endothelial cells. One way to test these hypotheses is to block endothelial function and measure the effect on BDNF levels and cognitive performance. The CBF and oxidative stress can also be examined in relationship to BDNF using a multiple linear regression...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28816203/using-mindfulness-to-reduce-the-health-effects-of-community-reaction-to-aircraft-noise
#20
REVIEW
Andrew J Hede
AIM: This paper investigates whether mindfulness-based interventions might ameliorate the detrimental health effects of aircraft noise on residential communities. REVIEW: Numerous empirical studies over the past 50 years have demonstrated the increasing negative impact of aircraft noise on residents worldwide. However, extensive database searches have revealed no published studies on psychological interventions that reduce residents' reactivity to environmental noise...
July 2017: Noise & Health
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