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https://www.readbyqxmd.com/read/27873145/use-of-refrigerant-spray-of-a-propane-butane-isobutane-gas-mixture-in-the-management-of-keratocystic-odontogenic-tumors-a-preliminary-study
#1
Eduardo Luis de Souza Cruz, Ana Karla da Silva Tabosa, Aline Semblano Carreira Falcão, Talita Tartari, Lucas Machado de Menezes, Edmar Tavares da Costa, José Thiers Carneiro Júnior
PURPOSE: Keratocystic odontogenic tumor (KCOT) is an aggressive benign tumor and the management by complete enucleation followed by cryotherapy maintains the inorganic bone matrix, resulting in better repair and reduces the rates of recurrence. A refrigerant spray with a propane/butane/isobutane gas mixture has been pointed to as an alternative to liquid nitrogen, because the device is easy to handle and contain within the cavity, providing better control and lower risk of injury to the adjacent soft tissue...
November 21, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27853924/retrospective-analysis-of-nonendodontic-periapical-lesions-misdiagnosed-as-endodontic-apical-periodontitis-lesions-in-a-population-of-taiwanese-patients
#2
Hsun-Yu Huang, Yuk-Kwan Chen, Edward Cheng-Chuan Ko, Fu-Hsiung Chuang, Ping-Ho Chen, Ching-Yi Chen, Wen-Chen Wang
OBJECTIVE: We aimed to evaluate nonendodontic periapical lesions clinically misdiagnosed as endodontic periapical pathoses in a population of Taiwanese patients. MATERIALS AND METHODS: Cases (2000-2014) of histopathological diagnoses of nonendodontic periapical lesions were retrieved from all cases with a clinical diagnosis of radicular cyst, apical granuloma, or apical periodontitis in the institution. These cases were regarded as misdiagnosed nonendodontic periapical lesions, of which the types and frequencies, in addition to the demographic data, were determined...
November 16, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27847737/treatment-of-nevoid-basal-cell-carcinoma-syndrome-a-case-report
#3
Dong-Uk Seo, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is characterized by various embryological deformities and carcinoma formation. It is caused by PTCHI gene mutations and is autosomal dominantly inherited. Some of the main symptoms of NBCCS are multiple basal cell carcinomas, multiple keratocystic odontogenic tumors (KCOTs) of the mandible, hyperkeratosis of the palmar and plantar, skeletal deformity, calcification of the falx cerebri, and facial defomity. Recurrent KCOT is the main symptom of NBCCS and is present in approximately 90% of patients...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27833347/treatment-of-keratocystic-odontogenic-tumours-a-prospective-study-of-30-cases
#4
Ashish Gupta, Pankaj Bansal, Rahul Sharma, Sneha D Sharma
AIM: This prospective study aimed at presenting different treatment modalities and its association with the recurrence rate of KCOT. MATERIAL AND METHOD: The study was conducted on 30 patients diagnosed with KCOT between March 2009 and 2012. The patients were followed up for a period of at least 1 year. The clinical, radiographic and demographic data were recorded and four different treatment modalities were followed to assess the recurrence of the tumour. RESULTS: In the study, KCOT showed male predominance with a male: female ratio of 23:7...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27747382/clinicopathological-and-cell-proliferation-evaluation-of-ameloblastomas-and-keratocystic-odontogenic-tumors-a-10%C3%A2-year-retrospective-study
#5
Leorik Pereira da Silva, Marianna Sampaio Serpa, Thalita Santana, George João Ferreira do Nascimento, Emanuel Sávio de Souza Andrade, Ana Paula Veras Sobral
Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs...
October 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27723645/keratocystic-odontogenic-tumor-with-ossification-and-calcification-a-case-report-with-unusual-histological-findings
#6
Swati Shrikant Gotmare, Avinash Tamgadge, Treville Pereira, Anusha Shetty
The keratocystic odontogenic tumor (KCOT), formerly known as odontogenic keratocyst, is a benign developmental odontogenic tumor with many distinguishing clinical and histologic features. Hard tissue deposits, which usually take the form of dystrophic calcifications, cartilaginous tissue, or dentinoid, are uncommon findings in the connective tissue capsule of the KCOT. We report a case of a 33-year-old female with KCOT showing osseous tissue and calcified deposits close to its epithelial lining, which is an extremely rare occurrence...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27627864/immunohistochemical-analysis-of-myofibroblasts-tgf-%C3%AE-1-and-ifn-%C3%AE-in-epithelial-odontogenic-lesions
#7
Pedro Paulo de Andrade Santos, Cassiano Francisco Weege Nonaka, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
AIM: To investigate the presence of myofibroblasts (MFBs) in epithelial odontogenic lesions by immunohistochemistry and to correlate the findings with tumor aggressiveness, as well as to analyze the expression of TGF-β1 and IFN-γ during the differentiation of these cells. METHODS AND RESULTS: Twenty solid ameloblastomas (SAs), 10 unicystic ameloblastomas (UAs), 20 keratocystic odontogenic tumors (KCOTs), and 20 adenomatoid odontogenic tumors (AOTs) were selected...
September 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27607111/endoscope-assisted-enucleation-of-mandibular-odontogenic-keratocyst-tumors
#8
Antonio Romano, Giovanni D A Orabona, Vincenzo Abbate, Fabio Maglitto, Domenico Solari, Giorgio Iaconetta, Luigi Califano
The keratocyst odontogenic tumor (KCOT) represents a rare and benign but locally aggressive developmental cystic lesion usually affecting the posterior aspect of the mandible bone, the treatment of which has always been raising debate, since Philipsen first described it as a distinct pathological entity in 1956.Recent studies have proposed the use of endoscope-assisted surgical technique, due to the possibility given by the endoscope of improving the effectiveness of the treatment of these lesions thanks to a better visualization of operative field and though a better understanding of the pathology...
September 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27601810/immunohistochemical-evaluation-of-myofibroblasts-in-odontogenic-cysts-and-tumors-a-comparative-study
#9
Deepa Syamala, Rakesh Suresh, Mahija Janardhanan, Vindhya Savithri, Prem P Anand, Amrutha Jose
CONTEXT: Myofibroblasts are fibroblasts with smooth muscle-like features characterized by the presence of a contractile apparatus and found in the connective tissue stroma of normal tissues such as blood vessels and lymph nodes. They are now thought to play a role in the synthesis and reorganization of extracellular matrix, which could contribute to the aggressive biologic behavior of the lesions. AIMS: To compare the mean number of stromal myofibroblasts in dentigerous cysts (DCs), keratocystic odontogenic tumor (KCOT) and ameloblastoma; and to derive a correlation between the stromal myofibroblasts and the known biologic behavior of the lesions...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27501963/orthokeratinized-odontogenic-cyst-with-an-associated-keratocystic-odontogenic-tumor-component-and-ghost-cell-keratinization-and-calcifications-in-a-patient-with-gardner-syndrome
#10
Prokopios P Argyris, Ioannis G Koutlas
Gardner syndrome (GS) is caused by mutations in the APC and besides adenomatous colorectal polyps includes such manifestations as osteomas, epidermoid cysts (ECs) and occasionally multiple pilomatricomas. More than 50 % of ECs in patients with GS exhibit pilomatricoma-like ghost cell keratinization. The latter may be explained by the fact that the development of both GS and pilomatricoma is driven by activation of the Wnt/β-catenin signaling pathway. A 62-year-old, Caucasian male with history of GS presented with a unilocular, mixed radiopaque/radiolucent mandibular lesion causing divergence and external root resorption of involved teeth...
August 8, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27475695/keratocystic-odontogenic-tumor-a-biopsy-service-s-experience-with-104-solitary-multiple-and-recurrent-lesions
#11
I-O Bello
BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple and recurrent KCOT in a Saudi Arabian population. MATERIAL AND METHODS: Biopsy request forms, pathology records and archival materials (all histological slides) of 104 cases of KCOT from 75 patients were retrieved...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27448602/mutiple-keratocystic-odontogenic-tumors-kcot-in-a-patient-with-gorlin-syndrome-a-case-report-with-late-presentation-and-absence-of-skin-manifestations
#12
Atif Ali Hashmi, Muhammad Muzzammil Edhi, Naveen Faridi, Mervyn Hosein, Mehmood Khan
BACKGROUND: Gorlin syndrome is a rare autosomal dominant syndrome characterized by multiple basal cell carcinomas, keratocystic odontogenic tumors (KOT) and falx cerebral calcifications, which occur due to mutation in PTCH gene. CASE PRESENTATION: A 36 year old Asian patient presented with jaw swelling and pain. Radiographic examination revealed six cysts in maxilla and mandible which were excised and histologically were compatable with keratocystic odontogenic tumors...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27398171/cd166-expression-in-dentigerous-cyst-keratocystic-odontogenic-tumor-and-ameloblastoma
#13
Azadeh Andisheh-Tadbir, Ali Gorgizadeh
BACKGROUND: CD166 is a glycoprotein of an immunoglobulin super family of adhesion molecules that has been associated with aggressive characteristics and high recurrence rate of tumors. Different odontogenic lesions exhibit considerable histological variation and different clinical behavior. In an attempt to clarify the mechanisms underlying this different behavior, the present study investigates the immunohistochemical expression of CD166 in these lesions. MATERIAL AND METHODS: In this study 69 formalin-fixed, paraffin embedded tissue blocks of odontogenic lesion consist of 15 unicystic ameloblastoma (UA), 17 solid ameloblastoma (SA), 18 keratocystic odontogenic tumors (KCOT), and 19 dentigerous cysts (DC) were reviewed by immunohistochemistry for CD166 staining...
July 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27391520/recurrent-keratocystic-odontogenic-tumor-after-effective-decompression
#14
Qian Zhang, Wei Li, Fangkai Han, Xiaofeng Huang, Xudong Yang
Keratocystic odontogenic tumor (KCOT) has potential aggressive and infiltrative behavior. Decompression has been widely preferred for large KCOTs due to safety and lower recurrence rates. However, KCOT is still likely to recur even after effective decompression. Here, we present a rare and interesting case of recurrent KCOT after effective decompression with adjunctive enucleation. Redecompression was then performed again, and the effect was still satisfactory on long-term follow-up.
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27391504/the-clinical-features-and-expression-of-bcl-2-cyclin-d1-p53-and-proliferating-cell-nuclear-antigen-in-syndromic-and-nonsyndromic-keratocystic-odontogenic-tumor
#15
Norliwati Ibrahim, Abdul Jabar Nazimi, Abdul Jalil Ajura, Rifqah Nordin, Zarina Abdul Latiff, Roszalina Ramli
UNLABELLED: The aim of this study was to describe the clinical features and expression of bcl-2, cyclin D1, p53, and proliferating cell nuclear antigen (PCNA) antibodies in syndromic (nevoid basal cell carcinoma syndrome [NBCCS]) and nonsyndromic patients diagnosed with keratocystic odontogenic tumor (KCOT). METHODS: This descriptive study comprised 5 patients of KCOT associated with NBCCS and 8 patients of nonsyndromic type treated in the Department of Oral Maxillofacial Surgery, Universiti Kebangsaan Malaysia Medical Centre between years 1998 and 2011...
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27381451/expression-of-astrocyte-elevated-gene-1-protein-in-ameloblastomas-keratocystic-odontogenic-tumors-and-dentigerous-cysts
#16
Yu-Hsueh Wu, Julia Yu-Fong Chang, Chih-Huang Tseng, Chun-Pin Chiang, Yi-Ping Wang
BACKGROUND: Benign epithelial odontogenic tumors such as ameloblastoma and keratocystic odontogenic tumor (KCOT) may exhibit an aggressive clinical course reminiscent of malignancies. Recent studies have indicated that astrocyte elevated gene-1 (AEG-1) is highly expressed in a variety of malignant neoplasms and its overexpression is associated with tumor invasion, metastasis, and poor survival. However, the role of AEG-1 in odontogenic tumors and cysts is still undiscovered. METHODS: Immunohistochemical staining of AEG-1 was performed in 42 cases of ameloblastoma, 29 cases of KCOT, and 19 cases of dentigerous cyst...
July 6, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27274347/the-role-of-vascular-endothelial-growth-factor-in-proliferation-of-odontogenic-cysts-and-tumors-an-immunohistochemical-study
#17
Bhavana Gupta, Shaleen Chandra, Anil Singh, Kunal Sah, Vineet Raj, Vivek Gupta
BACKGROUND: Vascular endothelial growth factor (VEGF) is capable of initiating angiogenesis in blood vessels and may act as mitogenic agent for epithelium of odontogenic cysts and tumors. This study was conducted to evaluate the role of epithelial VEGF expression in odontogenic cysts and ameloblastoma and its correlation with argyrophilic nucleolar organizer region counts to assess its role in their biological behavior. MATERIALS AND METHODS: In this retrospective cross-sectional study, 45 histologically confirmed cases, 15 cases of each of keratocystic odontogenic tumors (KCOTs), dentigerous cysts, and ameloblastomas were examined for immunohistochemical expression for epithelial VEGF, and argyrophilic nucleolar organizer regions (AgNORs) (used as secondary marker in this study) staining was done for comparing the proliferative capacity with VEGF...
May 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27195205/keratocystic-odontogenic-tumors-related-to-gorlin-goltz-syndrome-a-clinicopathological-study
#18
Mohammed Israr Ul Khaliq, Ajaz A Shah, Irshad Ahmad, Shahid Hasan, Sagar S Jangam, Farah, Anwar
BACKGROUND: Assess clinicopathological features of patients with keratocystic odontogenic tumor (KCOT) associated with Gorlin-Goltz syndrome in our institution from 2004 to 2015. METHOD: After histopathological analyses of KCOT related to Gorlin-Goltz syndrome, 7 patients were assessed. These patients presented a total of 15 primary and 2 recurrent KCOT. RESULTS: All patients presented a multiple KCOT, and 13 lesions were located in mandible (77%) and 4 (23%) in maxilla...
May 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27185307/application-of-diffusion-kurtosis-imaging-to-odontogenic-lesions-analysis-of-the-cystic-component
#19
Junichiro Sakamoto, Ami Kuribayashi, Shinya Kotaki, Mamiko Fujikura, Shin Nakamura, Tohru Kurabayashi
PURPOSE: To assess the feasibility of applying diffusion kurtosis imaging (DKI) to common odontogenic lesions and to compare its diagnostic ability versus that of the apparent diffusion coefficient (ADC) for differentiating keratocystic odontogenic tumors (KCOTs) from odontogenic cysts. MATERIALS AND METHODS: Altogether, 35 odontogenic lesions were studied: 24 odontogenic cysts, six KCOTs, and five ameloblastomas. The diffusion coefficient (D) and excessive kurtosis (K) were obtained from diffusion-weighted images at b-values of 0, 500, 1000, and 1500 s/mm(2) on 3T magnetic resonance imaging (MRI)...
December 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27134450/immunohistochemical-expression-of-vascular-endothelial-growth-factor-in-keratocystic-odontogenic-tumor-dentigerous-cyst-and-radicular-cyst-a-comparative-study
#20
Nidhi Khajuria, Rashmi Metgud, Smitha Naik, Sahul Lerra, Priya Tiwari, Mamta, Payal Katakwar, Anirudh Tak
BACKGROUND: Cyst and tumors arise from tissue remains of odontogenesis, these interactions have been considered to play an important role in the tumorigenesis of odontogenic lesions. The connective tissue stroma has an essential role in the preservation of epithelial tissues and minor alterations in the epithelium are followed by corresponding changes in the stroma, such as angiogenesis. Vascular endothelial growth factor (VEGF) is considered the first factor which maintains its position as the most critical driver of vascular formation and is required to initiate the formation of immature vessels, with this aim, present study was executed to evaluate VEGF expression in kertocystic odontogenic tumor, dentigerous cyst and radicular cyst (RC)...
January 2016: Indian Journal of Dentistry
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