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https://www.readbyqxmd.com/read/28345684/-analysis-of-changes-in-radiographic-lung-image-and-lung-ventilation-disorders-in-workers-occupationally-exposed-to-chrysotile-in-the-past
#1
Elżbieta Cwynar, Beata Świątkowska, Jarosław Tomczyk
BACKGROUND: The adverse health effects of occupational exposure to asbestos dust may occur several years after first exposure. The objective of the study was to assess the relationship between lesions in the respiratory system and the factors contributing to occupational exposure to asbestos described in the first medical examination as well as to analyze the factors responsible for the progression of these changes in further medical tests. MATERIAL AND METHODS: The study group comprised 591 former workers of asbestos processing plant "Gambit" in Lubawka...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28344849/developing-asbestos-job-exposure-matrix-using-occupation-and-industry-specific-exposure-data-1984-2008-in-republic-of-korea
#2
Sangjun Choi, Dongmug Kang, Donguk Park, Hyunhee Lee, Bongkyoo Choi
BACKGROUND: The goal of this study is to develop a general population job-exposure matrix (GPJEM) on asbestos to estimate occupational asbestos exposure levels in the Republic of Korea. METHODS: Three Korean domestic quantitative exposure datasets collected from 1984 to 2008 were used to build the GPJEM. Exposure groups in collected data were reclassified based on the current Korean Standard Industrial Classification (9(th) edition) and the Korean Standard Classification of Occupations code (6(th) edition) that is in accordance to international standards...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28344838/establishing-a-policy-framework-for-the-primary-prevention-of-occupational-cancer-a-proposal-based-on-a-prospective-health-policy-analysis
#3
Amanda Veglia, Manisha Pahwa, Paul A Demers
BACKGROUND: Despite our knowledge of the causes of cancer, millions of workers are involuntarily exposed to a wide range of known and suspected carcinogens in the workplace. To address this issue from a policy perspective, we developed a policy framework based on a prospective health policy analysis. Use of the framework was demonstrated for developing policies to prevent cancers associated with diesel engine exhaust (DEE), asbestos, and shift work, three occupational carcinogens with global reach and large cancer impact...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28343162/mesothelin-promoter-variants-are-associated-with-increased-soluble-mesothelin-related-peptide-levels-in-asbestos-exposed-individuals
#4
Chiara De Santi, Perla Pucci, Alessandra Bonotti, Ombretta Melaiu, Monica Cipollini, Roberto Silvestri, Veronika Vymetalkova, Elisa Barone, Elisa Paolicchi, Alda Corrado, Irene Lepori, Irene Dell'Anno, Lucia Pellè, Pavel Vodicka, Luciano Mutti, Rudy Foddis, Alfonso Cristaudo, Federica Gemignani, Stefano Landi
BACKGROUND: Soluble mesothelin-related peptide (SMRP) is a promising diagnostic biomarker for malignant pleural mesothelioma (MPM), but various confounders hinder its usefulness in surveillance programmes. We previously showed that a single nucleotide polymorphism (SNP) within the 3'untranslated region (3'UTR) of the mesothelin (MSLN) gene could affect the levels of SMRP. OBJECTIVES: To focus on SNPs located within MSLN promoter as possible critical genetic variables in determining SMRP levels...
March 25, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28341208/geometry-of-carbon-nanotubes-and-mechanisms-of-phagocytosis-and-toxic-effects
#5
Vasyl Michael Harik
A review of in vivo and in vitro toxicological studies of the potential toxic effects of carbon nanotubes is presented along with the analysis of experimental data and a hypothesis about the nanotube-asbestos similarity. Developments of the structure-activity paradigm have been reviewed along with the size effects and the classification of carbon nanotubes into eleven distinct classes (e.g., the high aspect ratio nanotubes, thick multi-wall nanotubes and short nanotubes). Scaling analysis of similarities between different classes of carbon nanotubes and asbestos fibers in the context of their potential toxicity and the efficiency of phagocytosis has been reviewed...
March 21, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28339042/immunomodulatory-effects-in-workers-exposed-to-naturally-occurring-asbestos-fibers
#6
Caterina Ledda, Chiara Costa, Serena Matera, Beatrice Puglisi, Valentina Costanzo, Massimo Bracci, Concettina Fenga, Venerando Rapisarda, Carla Loreto
Natural asbestiform fibers are defined 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337371/combinational-therapy-of-crizotinib-and-afatinib-for-malignant-pleural-mesothelioma
#7
Liyan Huang, Muyan Cai, Xu Zhang, Fang Wang, Likun Chen, Meng Xu, Ke Yang, Zhen Chen, Xiaokun Wang, Liwu Fu
Malignant pleural mesothelioma (MPM) is a relative rare but highly aggressive neoplasm which is associated with asbestos exposure in most patients. The majority of patients are diagnosed in advanced stages so patients neither benefit from chemotherapy (e.g. pemetrexed-platinum combination) nor from surgery. It has been reported that cellular-mesenchymal to epithelial transition factor (MET) and epidermal growth factor receptor (EGFR) were critical for MPM cell proliferation. Moreover, targeting MET and EGFR drugs have gained promising results on anti-tumor therapy...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28335760/midkine-is-a-potential-novel-marker-for-malignant-mesothelioma-with-different-prognostic-and-diagnostic-values-from-mesothelin
#8
Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima, Masatoshi Tagawa, Muzaffer Metintas
BACKGROUND: We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. METHODS: Serum mesothelin and midkine levels were determined with an enzyme-linked immunosorbent assay. We examined specimens from 95 Turkish cases with malignant pleural mesothelioma, 56 metastatic cancers to pleura, 27 other types of benign pleural diseases and 20 benign asbestos pleurisy...
March 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28332562/new-insights-on-the-biomineralisation-process-developing-in-human-lungs-around-inhaled-asbestos-fibres
#9
Fabrizio Bardelli, Giulia Veronesi, Silvana Capella, Donata Bellis, Laurent Charlet, Alessia Cedola, Elena Belluso
Once penetrated into the lungs of exposed people, asbestos induces an in vivo biomineralisation process that leads to the formation of a ferruginous coating embedding the fibres. The ensemble of the fibre and the coating is referred to as asbestos body and is believed to be responsible for the high toxicological outcome of asbestos. Lung tissue of two individuals subjected to prolonged occupational exposure to crocidolite asbestos was investigated using synchrotron radiation micro-probe tools. The distribution of K and of elements heavier than Fe (Zn, Cu, As, and Ba) in the asbestos bodies was observed for the first time...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28328293/history-of-knowledge-and-evolution-of-occupational-health-and-regulatory-aspects-of-asbestos-exposure-science-1900-1975
#10
Christy A Barlow, Jennifer Sahmel, Dennis J Paustenbach, John L Henshaw
The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health hazard, it was not until the mid-1950s that the carcinogenic nature of asbestos began to be characterized and widespread concern followed...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28322788/a-recombinant-polypeptide-of-the-megakaryocyte-potentiating-factor-is-a-potential-biomarker-in-plasma-for-the-detection-of-mesothelioma
#11
Irina Raiko, Hans-Peter Rihs, Jan Gleichenhagen, Ingrid Sander, Jens Kollmeier, Martin Lehnert, Thomas Brüning, Georg Johnen
Malignant mesothelioma (MM) is a fatal disease mostly associated with asbestos exposure and difficult to detect by non-invasive methods. This study aimed to use recombinant fragments of the megakaryocyte potentiating factor (MPF) for the development of cost-effective MPF ELISAs. Three polypeptides spanning the MPF region (MPF1-148, MPF 34-288, MPF/MSLN254-400) were produced in E.coli as maltose-binding protein hybrids. After isolation, Factor Xa digest, and purification, the polypeptides were used for the generation of rabbit antibodies and development of ELISAs...
March 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28321148/circulating-mir-132-3p-as-a-candidate-diagnostic-biomarker-for-malignant-mesothelioma
#12
Daniel G Weber, Katarzyna Gawrych, Swaantje Casjens, Alexander Brik, Martin Lehnert, Dirk Taeger, Beate Pesch, Jens Kollmeier, Torsten T Bauer, Georg Johnen, Thomas Brüning
The use of circulating microRNAs as biomarkers has opened new opportunities for diagnosis of cancer because microRNAs exhibit tumor-specific expression profiles. The aim of this study was the identification of circulating microRNAs in human plasma as potential biomarkers for the diagnosis of malignant mesothelioma. For discovery, TaqMan Low Density Array Human MicroRNA Cards were used to analyze 377 microRNAs in plasma samples from 21 mesothelioma patients and 21 asbestos-exposed controls. For verification, individual TaqMan microRNA assays were used for quantitative real-time PCR in plasma samples from 22 mesothelioma patients and 44 asbestos-exposed controls...
2017: Disease Markers
https://www.readbyqxmd.com/read/28283033/resting-and-feeding-preferences-of-anopheles-stephensi-in-an-urban-setting-perennial-for-malaria
#13
Shalu Thomas, Sangamithra Ravishankaran, N A Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B Thomas, Alex Eapen
BACKGROUND: The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present at low levels. The urban ecotype of malaria prevails in Chennai with perennial transmission despite vector surveillance by the Urban Malaria Scheme (UMS) of the National Vector Borne Disease Control Programme (NVBDCP). Understanding the feeding and resting preferences, together with the transmission potential of adult vectors in the area is essential in effective planning and execution of improved vector control measures...
March 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28281141/oxidative-potential-op-and-mineralogy-of-iron-ore-particulate-matter-at-the-gol-e-gohar-mining-and-industrial-facility-iran
#14
Naghmeh Soltani, Behnam Keshavarzi, Armin Sorooshian, Farid Moore, Christina Dunster, Ana Oliete Dominguez, Frank J Kelly, Prakash Dhakal, Mohamad Reza Ahmadi, Sina Asadi
Concentrations of total suspended particulate matter, particulate matter with aerodynamic diameter <2.5 μm (PM2.5), particulate matter <10 μm (PM10), and fallout dust were measured at the Iranian Gol-E-Gohar Mining and Industrial Facility. Samples were characterized in terms of mineralogy, morphology, and oxidative potential. Results show that indoor samples exceeded the 24-h PM2.5 and PM10 mass concentration limits (35 and 150 µg m(-3), respectively) set by the US National Ambient Air Quality Standards...
March 9, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28279517/recommendations-for-the-diagnosis-and-management-of-asbestos-related-pleural-and-pulmonary-disease
#15
Carmen Diego Roza, M Jesús Cruz Carmona, Ramón Fernández Álvarez, Jaume Ferrer Sancho, Belén Marín Martínez, Cristina Martínez González, José Antonio Rodríguez Portal, Fernando Romero Valero, Victoria Villena Garrido
Asbestos is the term used for a set of mineral silicates that tend to break up into fibers. Its use has been associated with numerous diseases affecting the lung and pleura in particular, all of which are characterized by their long period of latency. Asbestos, moreover, has been recognized by the WHO as a Group IA carcinogen since 1987 and its use was banned in Spain in 2002. The publication in 2013 of the 3rd edition of the specific asbestos health monitoring protocol, together with the development of new diagnostic techniques, prompted the SEPAR EROM group to sponsor publication of guidelines, which review the clinical, radiological and functional aspects of the different asbestos-related diseases...
March 6, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28276807/asbestos-ingestion-and-gastrointestinal-cancer-a-possible-underestimated-hazard
#16
Agostino Di Ciaula
The presence of asbestos fibres (AFs) in drinking water could be linked with gastrointestinal cancers. However, it is not regulated in several countries due to conflicting evidence. Areas covered: Some reports mainly associated AF ingestion with gastric and colorectal cancer. Experimental evidence suggested a role for timing and extent of exposure, and showed that ingested AFs induce toxic effects on the stomach, ileum and colon, histological alterations and negative effects at a molecular level, cross the placenta and enter foetal organs (including the liver), and seem able to act as a co-carcinogen agent...
March 6, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28272659/non-hodgkin-lymphoma-and-pleural-mesothelioma-in-a-person-exposed-to-asbestos
#17
Claudio Bianchi, Tommaso Bianchi
Non-Hodgkin lymphoma and pleural mesothelioma may co-exist in the same patient. A large cell non-Hodgkin lymphoma of the inguinal lymph nodes was diagnosed in a 73-year-old woman. The patient was treated by chemotherapy. She did not receive radiotherapy. The patient had been exposed to asbestos having worked in a cotton mill and in a distillery. Four years after the diagnosis of lymphoma, she presented with a left pleural effusion. Large biopsies of the pleura showed a malignant mesothelioma, biphasic type, and pleural plaques...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28261155/environmental-factors-impacting-bone-relevant-chemokines
#18
Justin T Smith, Andrew D Schneider, Karina M Katchko, Chawon Yun, Erin L Hsu
Chemokines play an important role in normal bone physiology and the pathophysiology of many bone diseases. The recent increased focus on the individual roles of this class of proteins in the context of bone has shown that members of the two major chemokine subfamilies-CC and CXC-support or promote the formation of new bone and the remodeling of existing bone in response to a myriad of stimuli. These chemotactic molecules are crucial in orchestrating appropriate cellular homing, osteoblastogenesis, and osteoclastogenesis during normal bone repair...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28258190/sirt3-deficiency-promotes-lung-fibrosis-by-augmenting-alveolar-epithelial-cell-mitochondrial-dna-damage-and-apoptosis
#19
Renea P Jablonski, Seok-Jo Kim, Paul Cheresh, David B Williams, Luisa Morales-Nebreda, Yuan Cheng, Anjana Yeldandi, Sangeeta Bhorade, Annie Pardo, Moises Selman, Karen Ridge, David Gius, G R Scott Budinger, David W Kamp
Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pulmonary fibrosis and asbestosis. Sirtuin 3 (SIRT3) detoxifies mitochondrial reactive oxygen species, in part, by deacetylating manganese superoxide dismutase (MnSOD) and mitochondrial 8-oxoguanine DNA glycosylase. We reasoned that SIRT3 deficiency occurs in fibrotic lungs and thereby augments AEC mtDNA damage and apoptosis. Human lungs were assessed by using immunohistochemistry for SIRT3 activity via acetylated MnSOD(K68) Murine AEC SIRT3 and cleaved caspase-9 (CC-9) expression were assayed by immunoblotting with or without SIRT3 enforced expression or silencing...
March 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28253224/malignant-mesothelioma-mortality-united-states-1999-2015
#20
Jacek M Mazurek, Girija Syamlal, John M Wood, Scott A Hendricks, Ainsley Weston
Malignant mesothelioma is a neoplasm associated with occupational and environmental inhalation exposure to asbestos* fibers and other elongate mineral particles (EMPs) (1-3). Patients have a median survival of approximately 1 year from the time of diagnosis (1). The latency period from first causative exposure to malignant mesothelioma development typically ranges from 20 to 40 years but can be as long as 71 years (2,3). Hazardous occupational exposures to asbestos fibers and other EMPs have occurred in a variety of industrial operations, including mining and milling, manufacturing, shipbuilding and repair, and construction (3)...
March 3, 2017: MMWR. Morbidity and Mortality Weekly Report
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