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Murray M Finkelstein
No abstract text is available yet for this article.
October 21, 2016: Laryngoscope
Nurhan Sahin, Ayse Nur Akatli, Muhammet Reha Celik, Hakkı Ulutas, Emine Turkmen Samdanci, Cemil Colak
Pleural Malignant Mesothelioma (MM) is a fatal disease that has been associated with asbestos exposure. Differential diagnosis between the pleural infiltration of pulmonary carcinomas and MM is rather difficult particularly for epitheloid type mesothelioma.We aimed to investigate the utility of CD90, a cancer stem cell marker, in the differential diagnosis of MM and lung carcinoma, its prognostic significance and compare its value with that of Calretinin. Ninety pathology specimens including MM (n:30), pulmonary adenocarcinoma (n:30) and pulmonary squamous cell carcinoma (n:30) were used in this study...
October 19, 2016: Pathology Oncology Research: POR
Valeria Ascoli, Ilaria Cozzi, Simona Vatrano, Stefania Izzo, Jessica Giorcelli, Elisa Romeo, Caterina Carnovale-Scalzo, Lucia Rosalba Grillo, Francesco Facciolo, Paolo Visca, Mauro Papotti, Luisella Righi
Familial malignant mesothelioma clusters are ideal candidates to explore BAP1 genomic status as a predisposing risk factor. We report data on BAP1 analysis in four families with multiple mesothelioma cases to investigate possible BAP1 alterations associated with an inherited cancer syndrome. We also recorded family history of cancer and assessed asbestos exposure. By genomic direct sequencing, we found no evidence of a BAP1 germline mutation in tumor DNA samples (one mesothelioma per family: n = 3 epithelioid; n = 1 biphasic)...
September 2016: Cancer Genetics
B Mrinakova, K Kajo, M Ondrusova, J Simo, D Ondrus
Paratesticular malignant mesothelioma is an extremely rare type of mesothelioma with only a limited number of reported cases. Its clinical differentiation is challenging, and its diagnosis is almost exclusively accidental. The major risk factor is exposure to asbestos, typically with a long latency between exposure and diagnosis. The current study presents the clinical data of two patients diagnosed with paratesticular malignant mesothelioma. We evaluated a large spectrum of risk factors in the patients histories...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Bruce Armstrong, Tim Driscoll
There has been much recent commentary about the 'third wave' of asbestos-related disease, arising particularly from exposures of people repairing, renovating or demolishing buildings that contain asbestos. The presence and extent of a third wave, however, are difficult to assess, and the extent and risk of both occupational and nonoccupational third-wave exposures are largely unmeasured. Moreover, we lack information on the extent of deterioration of in situ asbestos, and its significance for ambient and third-wave exposures...
April 15, 2016: Public Health Research & Practice
Dong-Mug Kang, Jong-Eun Kim, Ju-Young Kim, Hyun-Hee Lee, Young-Sik Hwang, Young-Ki Kim, Yong-Jin Lee
BACKGROUND: Because of the long asbestos-related disease latencies (10-50 years), detection, diagnosis, and epidemiologic studies require asbestos exposure history. However, environmental asbestos exposure source (EAES) data are lacking. OBJECTIVES: To survey the available data for past EAES and supplement these data with interviews. METHODS: We constructed an EAES database using a literature review and interviews of experts, former traders, and workers...
October 11, 2016: International Journal of Occupational and Environmental Health
Ahmed Elsadek Fakhr, Maha Kamal Gohar, Amal Hassan Atta
Fecal contamination of drinking water is a major health problem which accounts for many cases of diarrhea mainly in infants and foreigners. This contamination is a complex interaction of many parameters. Antibiotic resistance among bacterial isolates complicates the problem. The study was done to identify fecal contamination of drinking water by Diarrheagenic Antibiotic-Resistant Escherichia coli in Zagazig city and to trace reasons for such contamination, three hundred potable water samples were investigated for E...
2016: International Journal of Microbiology
Yasuo Morimoto, Norihiro Kobayashi
We reported the evaluations of the carcinogenicity of fluoro-edinite, silicon carbide, and carbon nanotubes performed by IARC working group in October 2014. For carbon nanotubes (CNTs), multi-walled carbon nanotube (MWCNT)-7 was classified as Group 2B, and MWCNTs without MWCNT-7 and single-walled carbon nanotubes (SWCNTs) were classified as not classifiable in terms of their carcinogenicity to humans. There is sufficient evidence of carcinogenicity for MWCNT-7 in experimental animals, limited evidence for other MWCNTs, and inadequate evidence for SWCNTs...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Toshiaki Sasaki, Masumi Asakura, Chigusa Ishioka, Tatsuya Kasai, Taku Katagiri, Shoji Fukushima
OBJECTIVES: IARC has classified one type of multi-walled carbon nanotubes (MWCNTs), MWNT-7, as possibly carcinogenic to humans (Group 2B); however, other types of MWCNT were categorized as not classifiable as to their carcinogenicity to humans (Group 3). In vitro chromosomal aberration assays of MWNT-7 showed polyploid formation but not structural abnormalities. This study investigated the influence of the shape and size of MWCNT on in vitro induction of chromosomal aberrations. METHODS: Microscopic analysis and viable cell counting were used to assay for chromosomal aberrations and cytotoxicity induced in a Chinese hamster lung cell line (CHL/IU) exposed to different MWCNTs...
October 7, 2016: Journal of Occupational Health
Jay Champlin, Rachael Edwards, Sudhakar Pipavath
Occupational lung diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and asbestos-related diseases as well as many immune-mediated and airway-centric diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis...
November 2016: Radiologic Clinics of North America
Ilaria Bononi, Manola Comar, Andrea Puozzo, Mariarita Stendardo, Piera Boschetto, Sara Orecchia, Roberta Libener, Roberto Guaschino, Silvia Pietrobon, Manuela Ferracin, Massimo Negrini, Fernanda Martini, Massimo Bovenzi, Mauro Tognon
Malignant pleural mesothelioma (MPM), a fatal cancer, is an occupational disease mostly affecting workers ex-exposed to asbestos fibers. The asbestos, a cancerogenic mineral of different chemical composition, was widely employed in western Countries in industrial manufactures of different types. MPM may arise after a long latency period, up to five decades. MPM is resistant to conventional chemo- and radio-therapies. Altogether, these data indicate that the identification of new and specific markers are of a paramount importance for an early diagnosis and treatment of MPM...
October 3, 2016: Oncotarget
Rosemary J Korda, Mark S Clements, Bruce K Armstrong, Susan M Trevenar, Elizabeth B Chalker, Leah A Newman, Martyn D Kirk
OBJECTIVES: Inhalation of asbestos fibres is the predominant cause of malignant mesothelioma. Domestic exposure to asbestos is a major community concern in the Australian Capital Territory (ACT) because of loose-fill asbestos home insulation. Little is known about how trends in mesothelioma rates in the ACT compare with those elsewhere. The objective of this study was to describe trends in mesothelioma rates in the ACT and compare them with those for the rest of Australia. METHODS: We used de-identified data from the ACT Cancer Registry (1982- 2014), and the Western Australia (WA) Cancer Registry and the Australian Cancer Database (1982-2011)...
September 30, 2016: Public Health Research & Practice
A Abelmann, M E Glynn, J S Pierce, P K Scott, D J Paustenbach
No abstract text is available yet for this article.
October 6, 2016: Inhalation Toxicology
Jeffrey L Levin, Alina Rouk, Sara Shepherd, George A Hurst, Jerry W McLarty
The Tyler asbestos plant produced pipe insulation from 1954 to 1972 and exclusively used amosite asbestos. There were 1130 former workers of this plant during the period of operation. A death certificate mortality analysis was published regarding this plant in 1998 for the period through 1993. This study represents an update of the mortality analysis with additional certificates collected for deaths occurring through 2011.Searches of the National Death Index database were conducted in 2004 and again in 2013...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Richard A Lemen
Mesothelioma, a rare tumor, is highly correlated with asbestos exposure. Mesothelioma, similar to all asbestos-related diseases, is dose/intensity dependent to some degree, and studies showed the risk of mesothelioma rises with cumulative exposures. Multiple processes occur in an individual before mesothelioma occurs. The impact of mesothelioma in the United States has been continuous over the last half century, claiming between 2,000 and 3,000 lives each year. Mesothelioma is a preventable tumor that is more frequently reported as associated with asbestos exposure among men than women...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Philip M Cook, Joseph Swintek, Timothy D Dawson, David Chapman, Mathew A Etterson, Dale Hoff
Cancer potencies of mineral and synthetic elongated particle mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. An extensive rat intrapleural dose characterization data set with a wide variety of elongated particles physicochemical properties facilitated statistical analyses of pleural mesothelioma response data combined from several studies for evaluation of alternative dose-response models...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Pascal Andujar, Aude Lacourt, Patrick Brochard, Jean-Claude Pairon, Marie-Claude Jaurand, Didier Jean
Despite the reduction of global asbestos consumption and production due to the ban or restriction of asbestos uses in more than 50 countries since the 1970s, malignant mesothelioma remains a disease of concern. Asbestos is still used, imported, and exported in several countries, and the number of mesothelioma deaths may be expected to increase in the next decades in these countries. Asbestos exposure is the main risk factor for malignant pleural mesothelioma, but other types of exposures are linked to the occurrence of this type of cancer...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
David Larson, Amy Powers, Jean-Paul Ambrosi, Mika Tanji, Andrea Napolitano, Erin G Flores, Francine Baumann, Laura Pellegrini, Cormac J Jennings, Brenda J Buck, Brett T McLaurin, Doug Merkler, Cleo Robinson, Paul Morris, Meral Dogan, A Umran Dogan, Harvey I Pass, Sandra Pastorino, Michele Carbone, Haining Yang
Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure to carcinogenic fibers was causing the development of MM. Palygorskite, a fibrous silicate mineral with a history of possible carcinogenicity, is abundant in southern Nevada. In this study, our aim was to determine whether palygorskite was contributing to the development of MM in southern Nevada...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Matthew J Soeberg, James Leigh, Nico van Zandwijk
Australia is known to have had the highest per-capita asbestos consumption level of any nation, reaching a peak in the 1970s. Although crocidolite was effectively banned in the late 1960s, and amosite use ceased in the mid 1980s, a complete asbestos ban was not implemented until 2003. This resulted in an epidemic of asbestos-related disease, which has only now reached its peak. Between 1982 and 2011, 13,036 individuals were newly diagnosed with malignant mesothelioma, with 690 diagnosed in 2011. A further 778 cases were identified between 1945 and 1981 from retrospective searches and the first 2 years of the Australian Mesothelioma Program...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Francine Baumann, Michele Carbone
Despite predictions of decline in mesothelioma following the ban of asbestos in most industrial countries, the incidence is still increasing globally, particularly in women. Because occupational exposure to asbestos is the main cause of mesothelioma, it occurs four- to eightfold more frequently in men than women, at a median age of 74 years. When mesothelioma is due to an environmental exposure, the M:F sex ratio is 1:1 and the median age at diagnosis is ~60 years. Studying environmental risk of mesothelioma is challenging because of the long latency period and small numbers, and because this type of exposure is involuntary and unknown...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
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