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https://www.readbyqxmd.com/read/29149883/serum-concentrations-of-krebs-von-den-lungen-6-surfactant-protein-d-and-matrix-metalloproteinase-2-as-diagnostic-biomarkers-in-patients-with-asbestosis-and-silicosis-a-case-control-study
#1
Changjiang Xue, Na Wu, Xue Li, Meihua Qiu, Xuqin Du, Qiao Ye
BACKGROUND: Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases. METHODS: The serum concentrations of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and matrix metalloproteinase-2 (MMP-2), MMP-7, and MMP-9 were measured in 43 patients with asbestosis, 45 patients with silicosis, 40 dust-exposed workers (DEWs) without pneumoconiosis, and 45 healthy controls (HCs)...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29137208/asbestos-ban-in-italy-a-major-milestone-not-the-final-cut
#2
Daniela Marsili, Alessia Angelini, Caterina Bruno, Marisa Corfiati, Alessandro Marinaccio, Stefano Silvestri, Amerigo Zona, Pietro Comba
Background and history: Italy was the main asbestos producer and one of the greatest consumers in 20th century Europe until the asbestos ban was introduced in 1992. Asbestos exposure affected the population in a wide range of working environments, namely mining and marketing of asbestos, asbestos cement production, shipyards and textile industries. This also determined a widespread environmental asbestos exposure affecting the surrounding communities. Methods: To investigate the drivers and difficulties of the process leading to the asbestos ban and its subsequent implementation, we focused on stakeholder involvement, environmental health policies, capacity building and communication...
November 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29133597/occupational-exposure-to-asbestos-and-risk-of-cholangiocarcinoma-a-population-based-case-control-study-in-four-nordic-countries
#3
Andrea Farioli, Kurt Straif, Giovanni Brandi, Stefania Curti, Kristina Kjaerheim, Jan Ivar Martinsen, Pär Sparen, Laufey Tryggvadottir, Elisabete Weiderpass, Guido Biasco, Francesco Saverio Violante, Stefano Mattioli, Eero Pukkala
OBJECTIVES: To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). METHODS: We conducted a case-control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29131723/comment-on-mesothelioma-from-asbestos-exposures-epidemiologic-patterns-and-impact-in-the-united-states-by-r-a-lemen-journal-of-toxicology-and-environmental-health-part-b-2016-19-250-265
#4
Corrado Magnani, Dario Mirabelli, Benedetto Terracini
No abstract text is available yet for this article.
November 13, 2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29129428/traffic-related-distribution-of-antimony-in-roadside-soils
#5
Corinna Földi, Simon Sauermann, Reiner Dohrmann, Tim Mansfeldt
Vehicular emissions have become one of the main source of pollution of urban soils; this highlights the need for more detailed research on various traffic-related emissions and related distribution patterns. Since the banning of asbestos in the European Union, its substitution with antimony (Sb) in brake linings has led to increased inputs of this toxic metalloid to environmental compartments. The objective of this study was to provide detailed information about the spatial distribution patterns of Sb and to assess its mobility and bioavailability...
November 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29129162/mesothelioma-in-australia-a-review
#6
Arthur Bill W Musk, Nicholas de Klerk, Fraser J Brims
The incidence of malignant mesothelioma in Australia is among the highest in the world as a result of widespread use of asbestos by industry and in construction throughout the 20th century. The risk of developing malignant mesothelioma after asbestos exposure is dose-related; a transient, low dose exposure confers a correspondingly very low risk of disease. Malignant mesothelioma is a heterogeneous disease, partly explaining the limited role of biomarkers in screening and diagnosis. The prognosis remains poor, and early advice on medico-legal compensation and a collaborative team approach to managing malignant mesothelioma are both essential...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29124998/evaluation-of-the-presence-of-asbestos-in-cosmetic-talcum-products
#7
Jennifer S Pierce, Alexander S Riordan, Eric W Miller, Shannon H Gaffney, Dana M Hollins
Talc has been used for over a century in a variety of cosmetic products. While pure cosmetic talc (free of asbestos) is not considered a risk factor for mesothelioma, it has been recently suggested that inhalation of cosmetic talc containing trace levels of asbestos is a risk factor for mesothelioma. Bulk analyses of cosmetic talcum products were performed in the 1960s and 1970s, however, the analytical methods used at that time were incapable of determining whether asbestos minerals were present in the asbestiform versus non-asbestiform habit...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29124996/a-30-year-mortality-and-respiratory-morbidity-study-of-refractory-ceramic-fiber-workers
#8
Grace LeMasters, James E Lockey, Timothy J Hilbert, Linda S Levin, Jeff W Burkle, Ralph Shipley, Charles Perme, Cristopher A Meyer, Carol H Rice
AIM: Report mortality (n = 1119), cancer incidence (n = 1207) and radiographic (n = 1451) findings from a 30-year investigation of current and former refractory ceramic fiber (RCF) workers. METHODS: Cause of death, health and work histories, radiographs and spirometry were collected. Mortality and cancer incidence were analyzed. Logistic regression analysis investigated the associations of latency and cumulative fiber exposure (CFE) on radiographic changes...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29113949/dysregulated-expression-of-the-microrna-mir-137-and-its-target-yb-1-contribute-to-the-invasive-characteristics-of-malignant-pleural-mesothelioma
#9
Thomas G Johnson, Karin Schelch, Yuen Y Cheng, Marissa Williams, Kadir H Sarun, Michaela B Kirschner, Steven Kao, Anthony Linton, Sonja Klebe, Brian C McCaughan, Ruby Cy Lin, Christine Pirker, Walter Berger, Annette Lasham, Nico van Zandwijk, Glen Reid
BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterised by frequent chromosomal deletions of tumour suppressors, including microRNAs. MiR-137 plays a tumour suppressor role in other cancers, so the aim of this study was to characterise it and its target Y-box binding protein-1 (YB-1) in MPM. BASIC PROCEDURES: Expression, methylation and copy number status of miR-137 and its host gene MIR137HG were assessed by PCR...
November 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29113529/pleuroparenchymal-fibroelastosis-with-long-history-of-asbestos-and-silicon-exposure
#10
Liyan Xu, Negar Rassaei, Carla Caruso
Pleuroparenchymal fibroelastosis (PPFE) is an uncommon interstitial lung disease. PPFE is characterized by fibroelastosis involving the pleura and subjacent parenchyma with a predominantly upper lobe distribution. While different possible environmental and familial etiologies have been postulated in the literature, the etiology of this disease remains essentially unclear and most cases are considered as idiopathic. In this report, we describe a rare case of PPFE with multiple lung lobe involvements and prolonged asbestos and silica exposure...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112873/mesothelioma-identical-routes-to-malignancy-from%C3%A2-asbestos-and-carbon-nanotubes
#11
Jennifer Port, Daniel J Murphy
Exposure of laboratory mice to carbon nanotubes mimics exposure to asbestos, from initial and chronic inflammation, through loss of the same tumour-suppressor pathways and eventual sporadic development of malignant mesothelioma. Fibres of a similar nature may pose significant health risks to humans.
November 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29112861/long-fiber-carbon-nanotubes-replicate-asbestos-induced-mesothelioma-with-disruption-of-the-tumor-suppressor-gene-cdkn2a-ink4a-arf
#12
Tatyana Chernova, Fiona A Murphy, Sara Galavotti, Xiao-Ming Sun, Ian R Powley, Stefano Grosso, Anja Schinwald, Joaquin Zacarias-Cabeza, Kate M Dudek, David Dinsdale, John Le Quesne, Jonathan Bennett, Apostolos Nakas, Peter Greaves, Craig A Poland, Ken Donaldson, Martin Bushell, Anne E Willis, Marion MacFarlane
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown. Moreover, late diagnosis means that mesothelioma research is commonly focused on end-stage disease. Although disruption of the CDKN2A (INK4A/ARF) locus has been reported in end-stage disease, information is lacking on the status of this key tumor suppressor gene in pleural lesions preceding mesothelioma...
November 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29111984/asbestos-exposures-mesothelioma-incidence-and-mortality-and-awareness-by-general-practitioners-in-the-molise-region-central-italy
#13
Giancarlo Ripabelli, Manuela Tamburro, Domiziana Di Tella, Francesco Carrozza, Michela Lucia Sammarco
OBJECTIVE: To evaluate environmental asbestos sources, mesothelioma incidence and mortality, awareness on asbestos-related diseases (ARD) by general practitioners (GPs) in Molise Region. METHODS: The contaminated sites in three towns were identified by census; mesothelioma incidence (2000-2012) and mortality (2003-2013) was achieved from local registries; GPs were interviewed on practiced population's exposures and ARD diagnosis. RESULTS: 54...
November 3, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29102973/parenchymal-asbestosis-due-to-primary-asbestos-exposure-among-ship-breaking-workers-report-of-the-first-cases-from-bangladesh
#14
Venkiteswaran Muralidhar, Md Faizul Ahasan, Ahad Mahmud Khan
We report for the first time asbestosis among ship-breaking workers of Sitakunda in Bangladesh who were exposed to asbestos during ship-based and beach-based operations for at least 10 years. Asbestosis was present among 35% of workers. Years of work (>20) and forced vital capacity (<80% of predicted) were significantly associated with the disease. Currently, global ship-breaking operations are mainly concentrated in the Indian subcontinent, and Bangladesh has the majority share. Ninety per cent of domestic steel is produced in the ship-breaking operations in Bangladesh and is an important contributor to the economy...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29101355/particles-of-different-sizes-and-shapes-induce-neutrophil-necroptosis-followed-by-the-release-of-neutrophil-extracellular-trap-like-chromatin
#15
Jyaysi Desai, Orestes Foresto-Neto, Mohsen Honarpisheh, Stefanie Steiger, Daigo Nakazawa, Bastian Popper, Eva Miriam Buhl, Peter Boor, Shrikant R Mulay, Hans-Joachim Anders
The human body is exposed to a wide range of particles of industrial, environmental or internal origin such as asbestos, alum, silica or crystals of urate, calcium phosphate, calcium oxalate, cystine or cholesterol. Phagocytic clearance of such particles involves neutrophils and macrophages. Here we report that neutrophils encountering such particles of diverse sizes and shapes undergo necrotic cell death, a process associated with the formation of neutrophil extracellular trap (NET)-like extracellular DNA...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100460/targeting-microrna-to-improve-diagnostic-and-therapeutic-approaches-for-malignant-mesothelioma
#16
REVIEW
Kimberly A Birnie, Cecilia M Prêle, Philip J Thompson, Bahareh Badrian, Steven E Mutsaers
Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099505/histological-findings-and-lung-dust-analysis-as-the-basis-for-occupational-disease-compensation-in-asbestos-related-lung-cancer-in-germany
#17
Inke Sabine Feder, Anja Theile, Andrea Tannapfel
OBJECTIVES: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. MATERIAL AND METHODS: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings...
November 2, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29089634/surface-reactivity-of-amphibole-asbestos-a-comparison-between-crocidolite-and-tremolite
#18
Giovanni B Andreozzi, Alessandro Pacella, Ingrid Corazzari, Maura Tomatis, Francesco Turci
Among asbestos minerals, fibrous riebeckite (crocidolite) and tremolite share the amphibole structure but largely differ in terms of their iron content and oxidation state. In asbestos toxicology, iron-generated free radicals are largely held as one of the causes of asbestos malignant effect. With the aim of clarifying i) the relationship between Fe occurrence and asbestos surface reactivity, and ii) how free-radical generation is modulated by surface modifications of the minerals, UICC crocidolite and fibrous tremolite from Maryland were leached from 1 day to 1 month in an oxidative medium buffered at pH 7...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29084128/the-effects-of-improving-the-mesothelioma-surveillance-network-on-sensitivity-timeliness-in-reporting-and-asbestos-exposure-assessment
#19
Lucia Mangone, Enza Di Felice, Cinzia Storchi, Antonio Romanelli, Serena Broccoli, Massimo Vicentini, Paolo Giorgi Rossi
BACKGROUND: In Italy, Mesothelioma Registries (MRs) have been established by law for the epidemiological surveillance of occupational cancers. MRs collect information about asbestos exposure of incident cases, through interviews. In the Emilia-Romagna region, MR was implemented in 1996 and extended its network of health professionals who report suspected mesothelioma in 2001 and 2007. OBJECTIVES: This study evaluated the impact of the extension of the network on MR sensitivity and timeliness...
October 27, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29083343/forensic-epidemiology-in-italy-principles-and-practice
#20
Valentina Chiesa, Anna Odone, Carlo Signorelli
Forensic epidemiology (FE) implies the use of epidemiological data in the processes and the involvement of epidemiologists in judicial proceedings. FE is essential for the assessment of causal association between the exposure to specific agents and the occurrence of diseases. In this paper we describe FE principles and applications in the Italian context as in recent years FE emerged increasingly as well as the need of experienced and trained epidemiological experts able to navigate legal proceedings. In the literature, the principles of FE have been widely described by different authors, among them: Kennet Rothman who introduced the definition of cause, Sir Austin Bradford Hill who proposed an analytic framework to assess the causal association, and recently by Sana Loue who described the actual legislation and application of FE in the United States...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
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