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https://www.readbyqxmd.com/read/28204826/pathway-deviation-based-biomarker-and-multi-effect-target-identification-in-asbestos-related-squamous-cell-carcinoma-of-the-lung
#1
Jiang Du, Lin Zhang
Asbestos-related lung carcinoma is one of the most devastating occupational cancers, and effective techniques for early diagnosis are still lacking. In the present study, a systematic approach was applied to detect a potential biomarker for asbestos-related lung cancer (ARLC); in particular asbestos-related squamous cell carcinoma (ARLC-SCC). Microarray data (GSE23822) were retrieved from the Gene Expression Omnibus database, including 26 ARLC-SCCs and 30 non-asbestos-related squamous cell lung carcinomas (NARLC-SCCs)...
February 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28204714/long-term-epidemiological-observation-of-asbestos-related-diseases-in-poland-1970-2015
#2
B Świątkowska, N Szeszenia-Dąbrowska
No abstract text is available yet for this article.
February 15, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28199862/effect-of-accelerating-voltage-on-beam-damage-of-asbestos-fibers-in-the-transmission-electron-microscope-tem
#3
Joannie Martin, Martin Beauparlant, Sébastien Sauvé, Gilles L'Espérance
Transmission electron microscopy (TEM) is a powerful and efficient tool for the analysis of asbestos fibers. Although this analysis technique is common and several standard methods exist for asbestos analysis, questions remain about the optimal conditions to be used. Because asbestos fibers are relatively sensitive to the electron beam, it is important to better understand the phenomena of damage in order to avoid them. This study specifically investigates the effect of the acceleration voltage on damage to four different types of asbestos fibers: chrysotile, amosite, crocidolite and anthophyllite...
January 25, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28197633/pim1-knockdown-inhibits-cell-proliferation-and-invasion-of-mesothelioma-cells
#4
Amany Sayed Mawas, Vishwa Jeet Amatya, Rui Suzuki, Kei Kushitani, Mouchira M Mohi El-Din, Yukio Takeshima
Malignant mesothelioma is a major asbestos-related cancer with prolonged time lapse from the first exposure of asbestos to the development of mesothelioma. Most of mesothelioma patients show very poor prognosis, thus, an urgent improvement of its treatment is required by development of novel therapeutic strategies. RNA interference (RNAi) is a powerful tool in post-genomic research and cancer therapy through inhibition of gene expression. In the present study, we analyzed the function of PIM1 on mesothelioma cell lines with its knockdown by siRNA transfection...
January 26, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28197626/kdm6a-and-kdm6b-altered-expression-in-malignant-pleural-mesothelioma
#5
Sian Cregan, Maeve Breslin, Gerard Roche, Sigrid Wennstedt, Lauren MacDonagh, Cinaria Albadri, Yun Gao, Kenneth J O'Byrne, Sinead Cuffe, Stephen P Finn, Steven G Gray
Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The current standard of care for patients suffering from MPM is a combination of cisplatin and pemetrexed (or alternatively cisplatin and raltitrexed). Most patients, however, die within 24 months of diagnosis. New therapies are therefore urgently required for this disease. Inflammation is thought to be a key element in the pathogenesis of MPM, and recently Kdm6 family members (Kdm6a and Kdm6b) have been identified as playing important roles in inflammatory processes...
February 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28194083/asbestos-induced-lung-disease-in-small-scale-clutch-manufacturing-workers
#6
Dipti Gothi, Tanushree Gahlot, Ram B Sah, Mayank Saxena, U C Ojha, Anand K Verma, Sonam Spalgais
BACKGROUND: The crocidolite variety of asbestos is banned. However, chrysotile, which is not prohibited, is still used in developing countries in making products such as clutch plate. Fourteen workers from a small-scale clutch plate-manufacturing factory were analyzed for asbestos-induced lung disease as one of their colleagues had expired due to asbestosis. AIMS: This study was conducted to evaluate the awareness of workers, the prevalence and type of asbestos-induced lung disease, and the sensitivity and specificity of diffusion test...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28191281/switching-off-malignant-mesothelioma-exploiting-the-hypoxic-microenvironment
#7
REVIEW
Noushin Nabavi, Kevin L Bennewith, Andrew Churg, Yuzhuo Wang, Colin C Collins, Luciano Mutti
Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity. The relative unspecific symptoms of mesotheliomas, misdiagnoses, and lack of precise targeted therapies call for a more critical assessment of this disease. In the present review, we categorize commonly identified genomic aberrations of mesotheliomas into their canonical pathways and discuss targeting these pathways in the context of tumor hypoxia, a hallmark of cancer known to render solid tumors more resistant to radiation and most chemo-therapy...
November 2016: Genes & Cancer
https://www.readbyqxmd.com/read/28188891/3-2-deoxy-%C3%AE-d-erythro-pentafuranosyl-pyrimido-1-2-%C3%AE-purin-10-3h-one-deoxyguanosine-adducts-of-workers-exposed-to-asbestos-fibers
#8
Stefano Bonassi, Filippo Cellai, Armelle Munnia, Donatella Ugolini, Alfonso Cristaudo, Monica Neri, Mirta Milić, Alessandra Bonotti, Roger W Giese, Marco E M Peluso
Asbestos is the commercial name for a group of silicate minerals naturally occurring in the environment and widely used in the industry. Asbestos exposure has been associated with pulmonary fibrosis, mesothelioma, and malignancies, which may appear after a period of latency of 20-40 years. Mechanisms involved in the carcinogenic effects of asbestos are still not fully elucidated, although the oxidative stress theory suggests that phagocytic cells produce large amounts of reactive oxygen species, due to their inability to digest asbestos fiber...
February 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28188606/costs-of-productivity-loss-due-to-occupational-cancer-in-canada-estimation-using-claims-data-from-workers-compensation-boards
#9
W Dominika Wranik, Adam Muir, Min Hu
INTRODUCTION: Cancer is a leading cause of illness globally, yet our understanding of the financial implications of cancer caused by working conditions and environments is limited. The goal of this study is to estimate the costs of productivity losses due to occupational cancer in Canada, and to evaluate the factors associated with these costs. METHODS: Two sources of data are used: (i) Individual level administrative claims data from the Workers Compensation Board of Nova Scotia; and (ii) provincial aggregated cancer claims statistics from the Association of Workers Compensation Boards of Canada...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28186988/hmgb1-targeting-by-ethyl-pyruvate-suppresses-malignant-phenotype-of-human-mesothelioma
#10
Laura Pellegrini, Jiaming Xue, David Larson, Sandra Pastorino, Sandro Jube, Kelly H Forest, Zeyana Salim Saad-Jube, Andrea Napolitano, Ian Pagano, Vishal S Negi, Marco E Bianchi, Paul Morris, Harvey I Pass, Giovanni Gaudino, Michele Carbone, Haining Yang
Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression. Moreover, we demonstrated that targeting HMGB1 inhibited MM cell growth and motility in vitro, reduced tumor growth in vivo, and prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester of pyruvic acid, has been shown to be an effective HMGB1 inhibitor in inflammation-related diseases and several cancers...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28183202/mesothelial-cell-autoantibodies-upregulate-transcription-factors-associated-with-fibrosis
#11
John Gilmer, Tanner Harding, Linda Woods, Brad Black, Raja Flores, Jean Pfau
Amphibole asbestos exposure is associated with the production of mesothelial cell autoantibodies (MCAA). These MCAA have been linked with pleural fibrotic disease in the asbestos exposed community of Libby, Montana, and induce collagen deposition by cultured mesothelial cells. However, the exact intracellular mechanism by which these autoantibodies cause an increase in collagen deposition remains unknown. This study sought to gain insight into the transcription factors involved in the collagen production after human mesothelial cells are exposed to MCAA...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28183200/spirometry-a-predictor-of-lung-cancer-among-asbestos-workers
#12
Beata Świątkowska, Neonila Szeszenia-Dąbrowska
OBJECTIVE: The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS: In order to identify a group of individuals with the highest risk of lung cancer incidence based on lung function levels of FEV1% predicted value, we examined 6882 subjects enrolled in the health surveillance program for asbestos related diseases over the years 2000-2014...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28177948/silicosis-and-autoimmunity
#13
Suni Lee, Hiroaki Hayashi, Hidenori Mastuzaki, Naoko Kumagai-Takei, Takemi Otsuki
PURPOSE OF REVIEW: Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. RECENT FINDINGS: With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown...
February 7, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28168071/two-case-reports-of-benign-testicular-mesothelioma-and-review-of-the-literature
#14
Cristobal Ramirez Sevilla, Carme Admella Salvador, Josep Feliu Canaleta, Juan Llopis Manzanera, Miguel Angel Barranco Sanz, Juan Antoni Romero Martin, Sergi Bernal Salguero
Mesothelioma is usually diagnosed in people over the age of 50 with large history of asbestos-related exposure. It is frequently located in pleural cavity, peritoneum, and pericardium. At the testicles the mesothelioma had been reported first in 1957 like a malignant non-germ-cells tumor. The objective is to present two case reports of benign testicular mesothelioma and review of the literature.
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28166467/mortality-among-coast-guard-shipyard-workers-a-retrospective-cohort-study-of-specific-exposures
#15
Jennifer Rusiecki, Patricia Stewart, Dara Lee, Melannie Alexander, Srmena Krstev, Debra Silverman, Aaron Blair
In a previous analysis of a cohort of shipyard workers, we found excess mortality from all causes, lung cancer, and mesothelioma for longer work durations and in specific occupations. Here, we expand the previous analyses by evaluating mortality associated with five chemical exposures: asbestos, solvents, lead, oils/greases, and wood dust. Data were gathered retrospectively for 4,702 workers employed at the Coast Guard Shipyard, Baltimore, MD (1950-1964). The cohort was traced through 2001 for vital status...
February 6, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#16
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28159026/design-and-validation-of-a-self-administered-questionnaire-as-an-aid-to-detection-of-occupational-exposure-to-lung-carcinogens
#17
C Pélissier, V Dutertre, P Fournel, I Gendre, J Michel Vergnon, J Kalecinski, F Tinquaut, L Fontana, F Chauvin
OBJECTIVE: Ten to thirty percent of lung cancer is thought to be of occupational origin. Lung cancer is under-declared as an occupational disease in Europe, and most declarations of occupational disease concern asbestos. The purpose of this study was to design and validate a short, sensitive self-administered questionnaire, as an aid for physicians in detecting occupational exposure to asbestos and other lung carcinogens in order to remedy occupational lung cancer under-declaration. STUDY DESIGN: Cross-sectional study...
February 2017: Public Health
https://www.readbyqxmd.com/read/28153512/paclitaxel-releasing-mesenchymal-stromal-cells-inhibit-in-vitro-proliferation-of-human-mesothelioma-cells
#18
Francesco Petrella, Valentina Coccè, Carla Masia, Martina Milani, Emanuela Omodeo Salè, Giulio Alessandri, Eugenio Parati, Francesca Sisto, Francesca Pentimalli, Anna T Brini, Augusto Pessina, Lorenzo Spaggiari
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare fatal asbestos-related malignancy originating in the mesothelial cells of the pleura. A platinum-based doublet containing a third-generation antifolate is the front-line standard of care whilst there are no approved second-line treatments for MPM which remains a disease setting to test the efficacy of new therapeutic agents. METHODS: Bone marrow mesenchymal stromal cells (BM-MSCs) were loaded with pemetrexed (PMX) and paclitaxel (PTX) according to a standardized procedure...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28152992/absence-of-multiplicative-interactions-between-occupational-lung-carcinogens-and-tobacco-smoking-a-systematic-review-involving-asbestos-crystalline-silica-and-diesel-engine-exhaust-emissions
#19
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Patrick Brochard, Fleur Delva, Aude Lacourt
BACKGROUND: Tobacco smoking is the main cause of lung cancer, but it is not the sole causal factor. Significant proportions of workers are smokers and exposed to occupational lung carcinogens. This study aims to systematically review the statistical interaction between occupational lung carcinogens and tobacco smoking, in particular asbestos, crystalline silica and diesel engine exhaust emissions. METHODS: Articles were identified using Scopus, PubMed, and Web of Science, and were limited to those published in English or French, without limitation of time...
February 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28151477/tissue-transglutaminase-tg2-enables-survival-of-human-malignant-pleural-mesothelioma-cells-in-hypoxia
#20
Sara Zonca, Giulia Pinton, Zhuo Wang, Maria Felicia Soluri, Daniela Tavian, Martin Griffin, Daniele Sblattero, Laura Moro
Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to environmental/occupational exposure to asbestos, characterized by the presence of significant areas of hypoxia. In this study, we firstly explored the expression and the role of transglutaminase 2 (TG2) in MPM cell adaptation to hypoxia. We demonstrated that cells derived from biphasic MPM express the full-length TG2 variant at higher levels than cells derived from epithelioid MPM and normal mesothelium. We observed a significant induction of TG2 expression and activity when cells from biphasic MPM were grown as a monolayer in chronic hypoxia or packed in spheroids, where the presence of a hypoxic core was demonstrated...
February 2, 2017: Cell Death & Disease
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