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https://www.readbyqxmd.com/read/28929108/different-cellular-response-of-human-mesothelial-cell-met-5a-to-short-term-and-long-term-multiwalled-carbon-nanotubes-exposure
#1
Li Ju, Wei Wu, Min Yu, Jianlin Lou, Hao Wu, Xianhong Yin, Zhenyu Jia, Yun Xiao, Lijin Zhu, Jun Yang
Despite being a commercially important product, multiwalled carbon nanotubes (MWCNTs) continue to raise concerns over human health due to their structural similarity to asbestos. Indeed, exposure to MWCNT has been shown to induce lung cancer and even mesothelioma, but contradictory results also exist. To clarify the potentially carcinogenic effects of rigid and rod-like MWCNT and to elucidate the underlying mechanisms, the effects of MWCNT on human mesothelial cell MeT-5A were examined throughout 3 months of continuous exposure, including cytotoxicity, genotoxicity, and cell motility...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28926737/people-planet-and-profit-unintended-consequences-of-legacy-building-materials
#2
REVIEW
Anthony T Zimmer, HakSoo Ha
Although an explosion of new building materials are being introduced into today's market, adequate up-front research into their chemical and physical properties as well as their potential health and environmental consequences is lacking. History has provided us with several examples where building materials were broadly deployed into society only to find that health and environmental problems resulted in unintended sustainability consequences. In the following paper, we use lead and asbestos as legacy building materials to show their similar historical trends and sustainability consequences...
September 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28915695/evaluation-of-intracavitary-administration-of-curcumin-for-the-treatment-of-sarcomatoid-mesothelioma
#3
Daniel L Pouliquen, Béatrice Nawrocki-Raby, Joëlle Nader, Stéphanie Blandin, Myriam Robard, Philippe Birembaut, Marc Grégoire
A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration. The M5-T1 cell line, selected from a collection established from F344 rats induced with asbestos, produces tumors within three weeks, with extended metastasis in normal tissues, after intraperitoneal inoculation in syngeneic rats. The optimal concentration/time conditions for killing M5-T1 cells with curcumin were first determined in vitro...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914691/time-trends-and-spatial-patterns-in-the-mesothelioma-incidence-in-slovenia-1961-2014
#4
Vesna Zadnik, Maja Primic Zakelj, Katja Jarm, Tina Zagar
We aimed to explore the temporal and spatial variations in mesothelioma incidence in Slovenia for the last 50 years and, among these, to evaluate the consequences of asbestos usage. The incidence data from the population-based Cancer Registry of Republic of Slovenia for the period 1961-2014 were analysed. The data of asbestos imported to Slovenia were used as a proxy for asbestos exposure in manufacturing areas. Log-linear joinpoint regression and age-period-cohort Poisson models were used in the time-trend analysis...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28913871/experimental-asbestos-studies-in-the-uk-1912-1950
#5
Morris Greenberg
The asbestos industry originated in the UK in the 1870s. By 1898, asbestos had many applications and was reported to be one of the four leading causes of severe occupational disease. In 1912, the UK government sponsored an experimental study that reported that exposure to asbestos produced no more than a modicum of pulmonary fibrosis in guinea pigs. In the 1930s, the newly established Medical Research Council, with assistance from industry, sponsored a study of the effects of exposing animals to asbestos by injection (intratracheal and subcutaneous) and by inhalation in the factory environment...
September 14, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28910456/identification-of-alk-rearrangements-in-malignant-peritoneal-mesothelioma
#6
Yin P Hung, Fei Dong, Jaclyn C Watkins, Valentina Nardi, Raphael Bueno, Paola Dal Cin, John J Godleski, Christopher P Crum, Lucian R Chirieac
Importance: Malignant peritoneal mesothelioma is a rare, aggressive tumor arising from the peritoneal lining, induced by asbestos, therapeutic radiation, or germline mutations. Nevertheless, the molecular features remain largely unknown. Objective: To investigate anaplastic lymphoma kinase (ALK) rearrangements in a large series of peritoneal mesothelioma and characterize the mutational landscape of these tumors. Design, Setting, and Participants: We studied 88 consecutive patients (39 men, 49 women; median age 61, range 17-84 years) with peritoneal mesotheliomas diagnosed at a single institution between 2005 and 2015...
September 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28905283/chrysotile-effects-on-the-expression-of-anti-oncogene-p53-and-p16-and-oncogene-c-jun-and-c-fos-in-wistar-rats-lung-tissues
#7
Yan Cui, Yuchan Wang, Jianjun Deng, Gongli Hu, Faqin Dong, Qingbi Zhang
Chrysotile is the most widely used form of asbestos worldwide. China is the world's largest consumer and second largest producer of chrysotile. The carcinogenicity of chrysotile has been extensively documented, and accumulative evidence has shown that chrysotile is capable of causing lung cancer and other forms of cancer. However, molecular mechanisms underlying the tumorigenic effects of chrysotile remained poorly understood. To explore the carcinogenicity of chrysotile, Wistar rats were administered by intratracheal instillation (by an artificial route of administration) for 0, 0...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28898889/chrysotile-causes-human-bronchial-epithelial-cell-apoptosis-in-response-to-the-fas-mediated-apoptosis-pathway
#8
Min Zhang, Junqiang Chen, Zhaoqiang Jiang, Lijin Zhu, Wei Wu, Yun Xiao, Kun Chen
AIMS: Asbestos is harmful to human health. However, the pathogenicity of chrysotile is a controversial matter. This study aimed to investigate the apoptosis of a human bronchial epithelial cell line (BEAS-2B) exposed to chrysotile that may function in part through the Fas death receptor pathway. METHODS: Cultured human BEAS-2B cells were treated with chrysotile and cell viability was evaluated by CCK-8 assay. The induction of cell apoptosis was evaluated by FACS analysis...
September 13, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28894485/asbestos-and-the-lung-highlights-of-a-detrimental-relationship
#9
Marianthi Iliopoulou, Clementine Bostantzoglou, Raffaella Nenna, Vasileios S Skouras
Novel aspects of the pathogenesis of asbestos-related diseases are still coming to light http://ow.ly/EPDa30e8JqK.
September 2017: Breathe
https://www.readbyqxmd.com/read/28893249/assessment-of-the-potential-respiratory-hazard-of-volcanic-ash-from-future-icelandic-eruptions-a-study-of-archived-basaltic-to-rhyolitic-ash-samples
#10
David E Damby, Claire J Horwell, Gudrun Larsen, Thorvaldur Thordarson, Maura Tomatis, Bice Fubini, Ken Donaldson
BACKGROUND: The eruptions of Eyjafjallajökull (2010) and Grímsvötn (2011), Iceland, triggered immediate, international consideration of the respiratory health hazard of inhaling volcanic ash, and prompted the need to estimate the potential hazard posed by future eruptions of Iceland's volcanoes to Icelandic and Northern European populations. METHODS: A physicochemical characterization and toxicological assessment was conducted on a suite of archived ash samples spanning the spectrum of past eruptions (basaltic to rhyolitic magmatic composition) of Icelandic volcanoes following a protocol specifically designed by the International Volcanic Health Hazard Network...
September 11, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28884745/clinicopathologic-and-genetic-characteristics-of-young-patients-with-pleural-diffuse-malignant-mesothelioma
#11
Marina Vivero, Raphael Bueno, Lucian R Chirieac
Pleural diffuse malignant mesothelioma typically presents during the seventh decade of life and has poor prognosis. Recent epidemiologic studies have shown differences between young and older mesothelioma patients, but the biology of pleural mesothelioma in young patients is poorly understood. We studied the clinicopathologic and genetic characteristics in pleural mesothelioma patients aged 35 years and younger. Thirty-six consecutive pleural mesothelioma patients aged 35 years and younger were compared with 48 older patients...
September 8, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28884469/cancer-of-the-esophagus-and-asbestos-exposure
#12
Bénédicte Clin, Isabelle Thaon, Mathilde Boulanger, Patrick Brochard, Soizick Chamming's, Antoine Gislard, Aude Lacourt, Amandine Luc, Guy Ogier, Christophe Paris, Jean-Claude Pairon
BACKGROUND: Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program). METHODS: A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos...
September 7, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28881848/biomarkers-for-early-diagnosis-of-malignant-mesothelioma-do-we-need-another-moonshot
#13
REVIEW
Sabrina Lagniau, Kevin Lamote, Jan P van Meerbeeck, Karim Y Vermaelen
Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection will result in better patient management and outcome. Many efforts have already been made to find suitable biomarkers in blood and pleural effusions, but have not yet resulted in a valid and reproducible diagnostic one. In this review, we will highlight the strengths and shortcomings of blood and fluid based biomarkers and highlight the potential of breath analysis as a non-invasive screening tool for MPM...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877715/exploring-efficacy-and-safety-of-oral-pirfenidone-for-progressive-non-ipf-lung-fibrosis-relief-a-randomized-double-blind-placebo-controlled-parallel-group-multi-center-phase-ii-trial
#14
Jürgen Behr, Petra Neuser, Antje Prasse, Michael Kreuter, Klaus Rabe, Carmen Schade-Brittinger, Jasmin Wagner, Andreas Günther
BACKGROUND: Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF) and offers a beneficial risk-benefit profile. However, there are several other, progressive fibrotic lung diseases, in which conventional anti-inflammatory therapy is not sufficiently effective and antifibrotic therapies may offer a novel treatment option. METHODS/DESIGN: We designed a study protocol for inclusion of patients with progressive fibrotic lung disease despite conventional anti-inflammatory therapy (EudraCT 2014-000861-32)...
September 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28870698/asbestos-insights-from-women
#15
Deborah H Yates
No abstract text is available yet for this article.
September 1, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28870655/comparative-health-effects-in-mice-of-libby-amphibole-asbestos-and-a-fibrous-amphibole-from-arizona
#16
Jean C Pfau, Brenda Buck, Rodney V Metcalf, Zoie Kaupish, Caleb Stair, Maria Rodriguez, Deborah E Keil
This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards...
September 7, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28870611/safety-and-activity-of-microrna-loaded-minicells-in-patients-with-recurrent-malignant-pleural-mesothelioma-a-first-in-man-phase-1-open-label-dose-escalation-study
#17
Nico van Zandwijk, Nick Pavlakis, Steven C Kao, Anthony Linton, Michael J Boyer, Stephen Clarke, Yennie Huynh, Agata Chrzanowska, Michael J Fulham, Dale L Bailey, Wendy A Cooper, Leonard Kritharides, Lloyd Ridley, Scott T Pattison, Jennifer MacDiarmid, Himanshu Brahmbhatt, Glen Reid
BACKGROUND: TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed tumour growth in preclinical models of malignant pleural mesothelioma. We aimed to assess the safety, optimal dosing, and activity of TargomiRs in patients with malignant pleural mesothelioma. METHODS: In this first-in-man, open-label, dose-escalation phase 1 trial at three major cancer centres in Sydney (NSW, Australia), we recruited adults (aged ≥18 years) with a confirmed diagnosis of malignant pleural mesothelioma, measurable disease, radiological signs of progression after previous chemotherapy, Eastern Cooperative Oncology Group performance status of 0 or 1, life expectancy of 3 months or more, immunohistochemical evidence of tumour EGFR expression, and adequate bone marrow, liver, and renal function...
September 1, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28866609/estimation-of-the-global-burden-of-mesothelioma-deaths-from-incomplete-national-mortality-data
#18
Chimed-Ochir Odgerel, Ken Takahashi, Tom Sorahan, Tim Driscoll, Christina Fitzmaurice, Makoto Yoko-O, Kittisak Sawanyawisuth, Sugio Furuya, Fumihiro Tanaka, Seichi Horie, Nico van Zandwijk, Jukka Takala
BACKGROUND: Mesothelioma is increasingly recognised as a global health issue and the assessment of its global burden is warranted. OBJECTIVES: To descriptively analyse national mortality data and to use reported and estimated data to calculate the global burden of mesothelioma deaths. METHODS: For the study period of 1994 to 2014, we grouped 230 countries into 59 countries with quality mesothelioma mortality data suitable to be used for reference rates, 45 countries with poor quality data and 126 countries with no data, based on the availability of data in the WHO Mortality Database...
September 2, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28863339/treatments-of-asbestos-containing-wastes
#19
REVIEW
D Spasiano, F Pirozzi
Since the second half of the twentieth century, many studies have indicated inhalation of asbestos fibers as the main cause of deadly diseases including fibrosis and cancer. Consequently, since the beginning of the 80s, many countries started banning production and use of asbestos containing products (ACP), although still present in private and public buildings. Due to some extraordinary catastrophic events and/or the aging of these products, people's health and environmental risk associated with the inhalation of asbestos fibers keeps being high even in those countries where it was banned...
August 29, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28863229/ambient-asbestos-fiber-concentrations-and-long-term-trends-in-pleural-mesothelioma-incidence-between-urban-and-rural-areas-in-the-united-states-1973-2012
#20
Meghan E Glynn, Kara A Keeton, Shannon H Gaffney, Jennifer Sahmel
Over the past 40 years, measured ambient asbestos concentrations in the United States have been higher in urban versus rural areas. The purpose of this study was to determine whether variations in ambient asbestos concentrations have influenced pleural mesothelioma risk in females (who generally lacked historic occupational asbestos exposure relative to males). Male pleural mesothelioma incidence trends were analyzed to provide perspective for female trends. Annual age-adjusted incidence rates from 1973 to 2012 were obtained from the SEER 9, 13, and 18 databases for urban and rural locations, and standardized rate ratios were calculated...
September 1, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
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