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https://www.readbyqxmd.com/read/28749105/compensation-for-asbestos-related-diseases-in-japan-utilization-of-standard-classifications-of-industry-and-occupations
#1
Kittisak Sawanyawisuth, Sugio Furuya, Eun-Kee Park, Jun-Pyo Myong, Juan Pablo Ramos-Bonilla, Odgerel Chimed Ochir, Ken Takahashi
Background: Asbestos-related diseases (ARD) are occupational hazards with high mortality rates. To identify asbestos exposure by previous occupation is the main issue for ARD compensation for workers. This study aimed to identify risk groups by applying standard classifications of industries and occupations to a national database of compensated ARD victims in Japan. Methods: We identified occupations that carry a risk of asbestos exposure according to the International Standard Industrial Classification of All Economic Activities (ISIC)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28744908/lung-cancer-in-a-patient-with-predominantly-short-tremolite-fibers-in-his-lung
#2
Norihiko Kohyama, Masaaki Fujiki, Takumi Kishimoto, Kenji Morinaga
The carcinogenicity of short tremolite fibers in human has not been cleared and has been argued hitherto. A lung cancer patient had worked at a gabbro quarry. Particles isolated from the excised lung parenchyma of the patient were measured for asbestos bodies (ABs) and asbestos fibers (AFs). The concentrations of ABs were 3964 AB/g dry lung, and AFs were 5.60 × 106 fibers/g dry lung (>5 um in length) and 22.5 × 106 fibers/g dry lung (>1 um in length). AFs were mostly tremolite fibers and under 7 um in length (mean length 4...
July 26, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28741519/cancer-prevention-lessons-learned-and-future-directions
#3
REVIEW
Barbara K Dunn, Barnett S Kramer
In this review, we address selected areas that are central to the state-of-the-art of cancer prevention science. The emphasis on prevention as a viable and critical approach to decreasing cancer mortality has gained traction in recent years, evidenced by its inclusion in the US Vice President's Cancer Initiative (also termed 'Moonshot'). Cancer prevention occurs by arresting, slowing down, or reversing the carcinogenic process before invasion into surrounding tissue or by avoiding or blocking causative exposure...
December 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28738894/occupational-exposure-to-chlorinated-solvents-and-risk-of-head-and-neck-cancer-in-men-a-population-based-case-control-study-in-france
#4
Christine Barul, Aurore Fayossé, Matthieu Carton, Corinne Pilorget, Anne-Sophie Woronoff, Isabelle Stücker, Danièle Luce
BACKGROUND: Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk. METHODS: We analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France)...
July 24, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28727529/-ain-t-necessarily-so-the-brake-industry-s-impact-on-asbestos-regulation-in-the-1970s
#5
David Rosner, Gerald Markowitz
Canada is proposing a ban on asbestos, and the US Environmental Protection Agency has listed it among the first 10 materials it is investigating under the new Toxic Substances Control Act revisions. However, this effort is currently running up against enormous industry and political opposition. Here, we detail the activities in the early 1970s of the Friction Materials Standards Institute, an industry trade association, to stifle earlier attempts to regulate asbestos use in brake linings, one of the oldest and most obvious sources of asbestos exposure to mechanics, among others...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28726176/quality-assessment-and-public-health-status-of-harvested-rainwater-in-a-peri-urban-community-in-edo-state-of-nigeria
#6
Isoken H Igbinosa, Isoken T Aighewi
The harvested rainwater is an alternative water source in communities where there is limited or scarcity of water distribution system. However, contamination of roof-harvested rainwater is of immense concern to the general public health. Therefore, this study was initiated to assess the levels of physicochemical quality and heavy metal concentrations in the harvested rainwater from Oluku communities in Benin City, Edo State, Nigeria. The roof-harvested rainwater samples were collected from 20 independent different residential households in Oluku communities, between April 2015 and September 2015...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28724330/immunotherapy-advances-for-mesothelioma-treatment
#7
Emyr Bakker, Alice Guazzelli, Firozeh Ashtiani, Constantinos Demonacos, Marija Krstic-Demonacos, Luciano Mutti
Mesothelioma is a rare type of cancer that is strongly tied to asbestos exposure. Despite application of different modalities such as chemotherapy, radiotherapy and surgery, patient prognosis remains very poor and therapies are ineffective. Much research currently focuses on the application of novel approaches such as immunotherapy towards this disease. Areas Covered: The types, stages and aetiology of mesothelioma are detailed, followed by a discussion of the current treatment options such as radiotherapy, surgery, and chemotherapy...
July 20, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28722770/asbestos-associated-genome-wide-dna-methylation-changes-in-lung-cancer
#8
Eeva Kettunen, Hector Hernandez-Vargas, Marie-Pierre Cros, Geoffroy Durand, Florence Le Calvez-Kelm, Kristina Stuopelyte, Sonata Jarmalaite, Kaisa Salmenkivi, Sisko Anttila, Henrik Wolff, Zdenko Herceg, Kirsti Husgafvel-Pursiainen
Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Illumina HumanMethylation450K BeadChip) of lung cancer tissue and paired normal lung from 28 asbestos-exposed or non-exposed patients, mostly smokers, revealed distinctive DNA methylation changes...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28713671/diagnostic-and-prognostic-biomarkers-for-malignant-mesothelioma-an-update
#9
REVIEW
Zhongjian Chen, Giovanni Gaudino, Harvey I Pass, Michele Carbone, Haining Yang
Malignant mesothelioma (MM) is an aggressive and lethal cancer, mostly related to inhalation of asbestos and erionite fibers. MM is associated with poor prognosis, because of its resistance to current therapies, even if higher survival occurs in patients diagnosed and treated when at stage I of the disease. However, these do not exceed 5% of the total number of cases, due to the inadequacy of the existing biomarkers for early and accurate diagnosis. Therefore, new effective biomarkers are needed for MM detection at earlier stages and to develop tailored therapies...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28713670/in-vitro-experimental-models-of-mesothelioma-revisited
#10
REVIEW
Anand Singh, Nathanael Pruett, Chuong D Hoang
Malignant pleural mesothelioma (MPM) is a biologically unusual, highly aggressive cancer that defies current multimodality treatments. Epidemiologic data suggest that this malignancy has not abated despite increasingly strict environmental regulations on asbestos, the putative causative agent for sporadic cases. An incomplete understanding of all the factors mechanistically driving mesothelioma is largely responsible for the current lack of curative treatments. Many approaches have been employed to ascertain the step-by-step molecular events involved in mesothelioma oncogenesis including in vitro, small animal in vivo, and human experimental models; though clearly defined, druggable mechanisms still are elusive...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28706912/diagnosis-and-prognosis-review-of-biomarkers-for-mesothelioma
#11
REVIEW
Huan H Sun, Allen Vaynblat, Harvey I Pass
Malignant pleural mesothelioma (MPM) is an aggressive disease arising in pleural cell lining and is associated with asbestos exposure. Today, there is a rising incidence of MPM reaching 3,000 annual cases nationally, primarily from the large population occupationally exposed to asbestos between 1940 and 1980. With a prolonged latency period, presenting clinically 10 to 40 years after exposure, MPM is often diagnosed in late stages and presents median survival time of less than 12 months. There is a serious need for improvement in prognostic and diagnostic tools for MPM...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706907/the-cappadocia-mesothelioma-epidemic-its-influence-in-turkey-and-abroad
#12
REVIEW
Salih A Emri
The epidemic of mesothelioma in Cappadocia, Turkey, is unprecedented in medical history. In three Cappadocian villages, Karain, Tuzkoy and "old" Sarihidir, about 50% of all deaths (including neonatal deaths and traffic fatalities) have been caused by mesothelioma. No other epidemic in medical history has caused such a high incidence of death. This is even more unusual when considering that (I) epidemics are caused by infectious agents, not cancer, and (II) mesothelioma is a rare cancer. World-wide mesothelioma incidence varies between 1/10(6) in areas with no asbestos industry to about 10-30/10(6) in areas with asbestos industry...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706906/mesothelioma-recent-highlights
#13
REVIEW
Michele Carbone, Haining Yang
Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. These discoveries are: (I) the critical role of chronic inflammation in promoting mesothelioma growth, driven by the release of high mobility group box protein-1 (HMGB1) following asbestos deposition in tissues and its potential role as a biomarker to identify asbestos exposed individuals and mesothelioma patients; (II) the discovery that inherited heterozygous germline mutations of the deubiquitylase BRCA-associated protein 1 (BAP1) cause a high incidence of mesothelioma in some families; and that (III) germline BAP1 mutations lower the threshold of asbestos required to cause mesothelioma in mice, evidence of gene X environment interaction...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706904/malignant-peritoneal-mesothelioma-a-review
#14
REVIEW
Joseph Kim, Shanel Bhagwandin, Daniel M Labow
Mesothelioma is a malignancy of serosal membranes. It is most commonly encountered in the visceral pleura with the second most common location in the peritoneum. The diagnosis is very rare and has been linked to toxic exposure to industrial pollutants, especially asbestos. Malignant peritoneal mesothelioma (MPM) commonly presents with diffuse, extensive spread throughout the abdomen with rare metastatic spread beyond the abdominal cavity. Due to its rarity and nonspecific symptoms, it is usually diagnosed late when the disease burden is extensive...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706903/overview-of-treatment-related-complications-in-malignant-pleural-mesothelioma
#15
REVIEW
David J Murphy, Ritu R Gill
Malignant pleural mesothelioma (MPM) is an aggressive malignant neoplasm of the pleura related to asbestos exposure. Despite recent advances in therapy for MPM, the prognosis remains poor, with considerable treatment associated morbidity. Radiological assessment plays a central role in the timely identification and subsequent management of treatment related complications in MPM. This review highlights common and uncommon complications associated with and encountered in the post treatment phase.
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706902/environmental-asbestos-exposure-and-risk-of-mesothelioma
#16
REVIEW
Curtis W Noonan
Mesothelioma is commonly considered an occupational disease occurring as a result of asbestos exposure in the workplace. Several avenues for environmental asbestos exposures have been described and may be associated with asbestos related disease, including mesothelioma. Worker take-home asbestos, or para-occupational exposure, has been well documented and is the most commonly reported pathway for asbestos exposure among mesothelioma cases that do not have history of occupational asbestos exposure. Observational studies have evaluated several communities with elevated mesothelioma incidence and environmental exposures attributed to local asbestos-related industries...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28704762/combined-inhibition-of-cdk4-6-and-pi3k-akt-mtor-pathways-induces-a-synergistic-anti-tumor-effect-in-malignant-pleural-mesothelioma-cells
#17
Mara A Bonelli, Graziana Digiacomo, Claudia Fumarola, Roberta Alfieri, Federico Quaini, Angela Falco, Denise Madeddu, Silvia La Monica, Daniele Cretella, Andrea Ravelli, Paola Ulivi, Michela Tebaldi, Daniele Calistri, Angelo Delmonte, Luca Ampollini, Paolo Carbognani, Marcello Tiseo, Andrea Cavazzoni, Pier Giorgio Petronini
Malignant pleural mesothelioma (MPM) is a progressive malignancy associated to the exposure of asbestos fibers. The most frequently inactivated tumor suppressor gene in MPM is CDKN2A/ARF, encoding for the cell cycle inhibitors p16(INK4a) and p14(ARF), deleted in about 70% of MPM cases. Considering the high frequency of alterations of this gene, we tested in MPM cells the efficacy of palbociclib (PD-0332991), a highly selective inhibitor of cyclin-dependent kinase (CDK) 4/6. The analyses were performed on a panel of MPM cell lines and on two primary culture cells from pleural effusion of patients with MPM...
July 10, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28697481/childhood-exposure-to-libby-amphibole-asbestos-and-respiratory-health-in-young-adults
#18
Patrick H Ryan, Carol H Rice, James E Lockey, Brad Black, Jeff Burkle, Timothy J Hilbert, Linda Levin, Cole Brokamp, Roy McKay, Christopher Wolfe, Grace K LeMasters
OBJECTIVES: Vermiculite ore containing Libby amphibole asbestos (LAA) was mined in Libby, MT, from the 1920s-1990. Recreational and residential areas in Libby were contaminated with LAA. This objective of this study was to characterize childhood exposure to LAA and investigate its association with respiratory health during young adulthood. METHODS: Young adults who resided in Libby prior to age 18 completed a health and activity questionnaire, pulmonary function testing, chest x-ray and HRCT scan...
July 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28691999/mortality-of-talc-miners-and-millers-from-val-chisone-northern-italy-an-updated-cohort-study
#19
Enrico Pira, Maurizio Coggiola, Catalina Ciocan, Canzio Romano, Carlo La Vecchia, Claudio Pelucchi, Paolo Boffetta
OBJECTIVE: The aim of this study was to update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. METHODS: We analyzed the mortality during 1946 to 2013 of 1722 male workers in an asbestos-free talc mine (1166 miners and 556 millers) employed during 1946 to 1995. RESULTS: The overall standardized mortality ratio (SMR) was 1.24 [95% confidence interval (95% CI) 1.17 to 1.32]; no deaths were observed from pleural cancer; mortality from lung cancer was not increased...
July 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28687356/germline-mutations-in-dna-repair-genes-predispose-asbestos-exposed-patients-to-malignant-pleural-mesothelioma
#20
Marta Betti, Elisabetta Casalone, Daniela Ferrante, Anna Aspesi, Giulia Morleo, Alessandra Biasi, Marika Sculco, Giuseppe Mancuso, Simonetta Guarrera, Luisella Righi, Federica Grosso, Roberta Libener, Mansueto Pavesi, Narciso Mariani, Caterina Casadio, Renzo Boldorini, Dario Mirabelli, Barbara Pasini, Corrado Magnani, Giuseppe Matullo, Irma Dianzani
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos exposure. An inherited predisposition has been suggested to explain multiple cases in the same family and the observation that not all individuals highly exposed to asbestos develop the tumor. Germline mutations in BAP1 are responsible for a rare cancer predisposition syndrome that includes predisposition to mesothelioma. We hypothesized that other genes involved in hereditary cancer syndromes could be responsible for the inherited mesothelioma predisposition...
July 4, 2017: Cancer Letters
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