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Canine Cruciate ligament

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https://www.readbyqxmd.com/read/29459502/innovative-intra-articular-prosthetic-technique-for-cranial-cruciate-ligament-reconstruction-in-dogs-a-cadaveric-study
#1
Luca Omini, Stefano Martin, Adolfo Maria Tambella
The purpose of this study was to describe and assess the feasibility of a new intra-articular approach in the treatment of cranial cruciate ligament deficiency in dogs using an artificial ligament and a new bone-anchor system. Twelve canine cadavers weighting 26 to 45 kg were used in this ex-vivo study. Special tibial and femoral screws, two helicoils, and a high resistance artificial fiber compose the implant. Surgery was performed using the mean cranio-lateral approach to the stifle joint. Helicoil and tibial screw, connected to the fiber, were inserted in the center of the tibial insertion area of the cranial cruciate ligament...
February 20, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29440589/intraobserver-and-interobserver-agreement-on-the-radiographical-diagnosis-of-canine-cranial-cruciate-ligament-rupture
#2
Evelien Bogaerts, Elke Van der Vekens, Geert Verhoeven, Hilde de Rooster, Bernadette Van Ryssen, Yves Samoy, Ingrid Putcuyps, Johan Van Tilburg, Nausikaa Devriendt, Frederik Weekers, Mileva Bertal, Blandine Houdellier, Stephanie Scheemaeker, Jeroen Versteken, Maryline Lamerand, Laurien Feenstra, Luc Peelman, Filip Van Nieuwerburgh, Jimmy H Saunders, Bart J G Broeckx
Even though radiography is one of the most frequently used imaging techniques for orthopaedic disorders, it has been demonstrated that the interpretation can vary between assessors. As such, the purpose of this study was to examine the intraobserver and interobserver agreement and the influence of level of expertise on the interpretation of radiographs of the stifle in dogs with and without cranial cruciate ligament rupture (CCLR). Sixteen observers, divided in four groups according to their level of experience, evaluated 30 radiographs (15 cases with CCLR and 15 control stifles) twice...
February 9, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29230875/kinetics-of-plasma-cell-free-dna-and-creatine-kinase-in-a-canine-model-of-tissue-injury
#3
I J Wilson, R K Burchell, A J Worth, S E Burton, K R Gedye, K J Clark, K R Crosse, M Jack, T F Odom, S J De Grey, K M S McGlade, S C Tomlin, N Lopez-Villalobos, A Gal
BACKGROUND: Cell-free DNA (cfDNA) comprises short, double-stranded circulating DNA sequences released from damaged cells. In people, cfDNA concentrations correlate well with disease severity and tissue damage. No reports are available regarding cfDNA kinetics in dogs. OBJECTIVES/HYPOTHESIS: Cell-free DNA will have a short biological half-life and would be able to stratify mild, moderate, and severe tissue injury. Our study aims were to determine the kinetics and biological half-life of cfDNA and to contrast them with those of creatine kinase (CK)...
December 12, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29202502/variation-in-the-quantity-of-elastic-fibres-with-degeneration-in-canine-cranial-cruciate-ligaments-from-labrador-retrievers
#4
Kinley D Smith, Kei Hayashi, Dylan N Clements, Peter D Clegg, John F Innes, Eithne J Comerford
Objectives This study aims to quantify numbers of elastic fibres in cranial cruciate ligaments from a dog breed at high risk of cranial cruciate ligament disease. Methods Macroscopically normal cranial cruciate ligaments were harvested from six Labrador retrievers. Sequential histological sections were assessed for extracellular matrix degeneration (haematoxylin and eosin stain) and elastic fibre staining (Miller's stain). Elastic fibres were semi-quantified using previously published scoring systems. Each section was scored twice by two observers...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29125013/diagnostic-value-of-combined-serum-marker-changes-and-quantitative-mri-evaluation-of-cartilage-volume-of-tibial-plateau-in-a-surgically-induced-osteoarthritis-dog-model
#5
Jiangdong Ren, Jinsai Ma, Xiaogang Zhang, Abdusami Aimaiti, Maimaitiming Saiyiti, Yuming Chen, Li Cao
Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29094513/accuracy-of-3-tesla-magnetic-resonance-imaging-using-detection-of-fiber-loss-and-a-visual-analog-scale-for-diagnosing-partial-and-complete-cranial-cruciate-ligament-ruptures-in-dogs
#6
Constance G Fazio, Peter Muir, Susan L Schaefer, Kenneth R Waller
Canine cranial cruciate ligament rupture is often bilateral and asymmetrical, ranging from partial to complete rupture. The purpose of our diagnostic accuracy study was to assess the accuracy of 3 Tesla magnetic resonance imaging (MRI) detection of fiber loss and use of a visual analog scale in the diagnosis of complete versus partial cranial cruciate ligament rupture in 28 clinical dogs with unilateral complete rupture and contralateral partial rupture. Three Tesla MRI was performed on 56 stifles using sagittal sequences (T2-weighted fast spin echo with fat saturation, proton density fast spin echo, and T2-weighted 3D fast spin echo CUBE)...
November 1, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29064569/a-modified-maquet-tibial-tuberosity-advancement-technique-for-treatment-of-canine-cranial-cruciate-ligament-disease-short-term-outcome-and-complications
#7
Lauren M Retallack, R Mark Daye
OBJECTIVE: To describe and report the outcomes of a novel modified Maquet-tibial tuberosity advancement (mTTA) technique in dogs with naturally occurring cranial cruciate ligament (CCL) rupture, compared to a traditional tibial tuberosity advancement (tTTA) technique. STUDY DESIGN: Descriptive report and retrospective clinical cohort study. SAMPLE POPULATION: Dogs (n = 70) treated via tibial tuberosity advancement (TTA). METHODS: Medical records (2013-2015) of dogs treated for CCL rupture via TTA were reviewed for: signalment, findings on physical examination, procedure (tTTA or mTTA), radiographs, complications, and outcome...
October 24, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28974260/in-vitro-characterization-of-canine-multipotent-stromal-cells-isolated-from-synovium-bone-marrow-and-adipose-tissue-a-donor-matched-comparative-study
#8
Robert N Bearden, Shannon S Huggins, Kevin J Cummings, Roger Smith, Carl A Gregory, William B Saunders
BACKGROUND: The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived from synovium, bone marrow, and adipose tissue using a donor-matched study design and a comprehensive series of in-vitro characterization, differentiation, and immunomodulation assays...
October 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#9
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na(18)F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28720297/comparison-of-tibial-anatomical-mechanical-axis-angle-between-predisposed-dogs-and-dogs-at-low-risk-for-cranial-cruciate-ligament-rupture
#10
COMPARATIVE STUDY
L Guénégo, M Payot, P Charru, P Verwaerde
The purpose of this prospective, radiographic, descriptive study was to compare measurements of tibial anatomical-mechanical axis angle (AMA-angle), tibial plateau angle (TPA), relative tibial tuberosity width (rTTW) and Z-angle from mediolateral radiographs of the tibia between two canine breeds (72 dogs) not predisposed to cranial cruciate ligament rupture (CCLR) and those from a consecutive series of 185 large dogs and 17 West Highland white terriers (WHWT) diagnosed with unilateral, surgically confirmed CCLR...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28654381/preclinical-multimodal-molecular-imaging-using-18-f-fdg-pet-ct-and-mri-in-a-phase-i-study-of-a-knee-osteoarthritis-in-in-vivo-canine-model
#11
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent (18)F-fluoro-d-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28642867/evaluation-of-the-effect-of-a-single-intra-articular-injection-of-allogeneic-neonatal-mesenchymal-stromal-cells-compared-to-oral-non-steroidal-anti-inflammatory-treatment-on-the-postoperative-musculoskeletal-status-and-gait-of-dogs-over-a-6-month-period-after
#12
Mathieu Taroni, Quentin Cabon, Marine Fèbre, Thibaut Cachon, Nathalie Saulnier, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert, Eric Viguier
OBJECTIVE: Compare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs). STUDY DESIGN: Prospective, double-blinded, randomized, controlled, monocentric clinical study...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28393962/surgical-stabilization-of-concomitant-canine-medial-patellar-luxation-and-cranial-cruciate-ligament-disease-effect-of-fixation-method-on-postoperative-complication-rate-and-clinical-outcome
#13
Albane H Fauron, Mieghan Bruce, Daniel R James, Mark A Owen, Karen L Perry
OBJECTIVES: To compare complication rates and outcomes between cases of concomitant cranial cruciate ligament (CrCL) disease and medial patellar luxation (MPL) treated using extracapsular stabilization and tibial tuberosity transposition (ECS+TTT) and tibial tuberosity transposition and advancement (TTTA). METHODS: In a multicentre retrospective study, records from four referral hospitals were reviewed for dogs with concomitant CrCL pathology and MPL treated using ECS+TTT or TTTA...
May 22, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28369965/canine-cranial-cruciate-ligament-deficient-stifle-biomechanics-associated-with-extra-articular-stabilization-predicted-using-a-computer-model
#14
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE: To evaluate lateral fabellotibial suture (LFTS) and TightRope CCL (TR) extra-articular stabilization biomechanics in the cranial cruciate ligament (CrCL)-deficient canine stifle joint during the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Healthy 33-kg Golden Retriever. METHODS: LFTS and TR were implemented in a previously developed 3-D quasi-static rigid body CrCL-deficient canine pelvic limb computer model simulating the stance phase of gait...
April 1, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28345997/evaluation-of-a-new-method-to-determine-the-tibial-tuberosity-advancement-distance-required-to-reduce-the-patellar-tendon-tibial-plateau-angle-to-90%C3%A2-with-the-modified-maquet-technique-in-dogs
#15
Paul Pillard, Veronique Livet, Quentin Cabon, Camille Bismuth, Juliette Sonet, Denise Remy, Didier Fau, Claude Carozzo, Eric Viguier, Thibaut Cachon
OBJECTIVE To assess use of a new radiographic method to determine the distance by which the tibial tuberosity should be advanced to reduce the patellar tendon-tibial plateau angle (PTA) to 90° by means of the modified Maquet technique (MMT) in dogs. SAMPLE 24 pelvic limbs from 12 adult medium-sized to large-breed canine cadavers. PROCEDURES Radiographs of stifle joints at 135° extension in true lateral position were used to determine tibial tuberosity advancement distances for use in the MMT. A method was devised to incorporate the planned osteotomy axis; distal patellar translations of 0, 3, 5, or 10 mm; and advancement cage implant application level along the osteotomy site in advancement planning measurements...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28345412/effect-of-glucosamine-sulfate-on-osteoarthritis-in-the-cruciate-deficient-canine-model-of-osteoarthritis
#16
Wolfram Wenz, Christian Hornung, Christopher Cramer, Malte Schroeder, Michael Hoffmann
Objective Osteoarthritis (OA) is a major cause of musculoskeletal pain and disability worldwide. The investigation of disease-modifying treatment options for OA has become an important aspect of orthopedic care. To assess the effect of intra-articular and oral glucosamine sulfate (GS) versus placebo on osteoarthritis in a canine model. Materials In this randomized, placebo-controlled, double-blinded study, OA was induced by anterior cruciate ligament transection (ACLT) according to the Pond-Nuki model in 32 canines...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28094860/tta-rapid-in-the-treatment-of-the-canine-cruciate-deficient-stifle-short-and-medium-term-outcome
#17
S J Butterworth, D M Kydd
OBJECTIVES: To evaluate complications, short- and medium-term outcomes following treatment of lameness associated with cranial cruciate ligament insufficiency in dogs using the "TTA-Rapid" technique. METHODS: Patient records from two veterinary clinics were retrospectively examined to collect data from cases treated over a period of 21 months. An owner postal questionnaire using a clinical metrology instrument (Liverpool Osteoarthritis in Dogs) evaluated medium-term outcome of at least six months...
January 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28090443/topographical-and-depth-dependent-glycosaminoglycan-concentration-in-canine-medial-tibial-cartilage-3-weeks-after-anterior-cruciate-ligament-transection-surgery-a-microscopic-imaging-study
#18
Daniel Mittelstaedt, David Kahn, Yang Xia
BACKGROUND: Medical imaging has become an invaluable tool to diagnose damage to cartilage. Depletion of glycosaminoglycans (GAG) has been shown to be one of the early signs of cartilage degradation. In order to investigate the topographical changes in GAG concentration caused by the anterior cruciate ligament transection (ACLT) surgery in a canine model, microscopic magnetic resonance imaging (µMRI) and microscopic computed tomography (µCT) were used to measure the GAG concentration with correlation from a biochemical assay, inductively coupled plasma optical emission spectroscopy (ICP-OES), to understand where the topographical and depth-dependent changes in the GAG concentration occur...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28075493/joint-stability-after-canine-cranial-cruciate-ligament-graft-reconstruction-varies-among-femoral-fixation-sites
#19
Louisa K Ho-Eckart, Masahiro Seki, Lindsey M Luizza, Michael T Kearney, Mandi J Lopez
OBJECTIVE: To quantify stability in cranial cruciate ligament (CrCL) deficient canine stifles with hamstring grafts affixed at 3 femoral locations. STUDY DESIGN: Canine stifle motion study using a multi-cohort, repeated measures design. SAMPLE POPULATION: 27 canine cadaver stifles. METHODS: Hamstring grafts (HG) were affixed at the gracilis-semitendinosus insertion and on the lateral femur (1) proximal trochlear ridge (TR), (2) craniodistal to fabella (F), or (3) condyle center (CC)...
February 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28068982/effect-of-proximal-translation-of-the-osteotomized-tibial-tuberosity-during-tibial-tuberosity-advancement-on-patellar-position-and-patellar-ligament-angle
#20
Jack D Neville-Towle, Mariano Makara, Kenneth A Johnson, Katja Voss
BACKGROUND: Cranial cruciate ligament insufficiency is a common orthopaedic problem in canine patients. This cadaveric and radiographic study was performed with the aim of determining the effect of proximal translation of the tibial tuberosity during tibial tuberosity advancement (TTA) on patellar position (PP) and patellar ligament angle (PLA). RESULTS: Disarticulated left hind limb specimens harvested from medium to large breed canine cadavers (n = 6) were used for this study...
January 9, 2017: BMC Veterinary Research
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