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Canine Cruciate ligament

Rebecca N Howie, Timothy L Foutz, Curtis C Cathcart, Jeff S Burmeister, Steve C Budsberg
OBJECTIVE: To investigate the relationship between tibiofemoral kinematics before and after total knee replacement (TKR) in vitro. ANIMALS: Eight canine hemipelves. METHODS: A modified Oxford Knee Rig was used to place cadaveric limbs through a range of passive motion allowing the kinematics of the stifle to be evaluated. Four measurements were performed: a control stage, followed by a cranial cruciate transection stage, then following TKR with the musculature intact stage, and finally TKR with removal of limb musculature stage...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Matthew D Barnhart, Karl Maritato, Kemal Schankereli, Harry Wotton, Steven Naber
OBJECTIVE: Evaluate the short-term outcomes of a novel synthetic ligament for treatment of naturally occurring canine cranial cruciate ligament disease. STUDY DESIGN: Prospective clinical study. ANIMALS: Dogs with unilateral cranial cruciate ligament disease (n = 50). METHODS: Patient parameters evaluated included a five-point lameness score, evaluation of craniocaudal stifle instability and radiographic findings over 24 weeks...
October 6, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
Nick S Rappa, Robert M Radasch
This study classified and determined the post-operative complication rate associated with stabilization of cranial (CCL) ligament deficient stifles in small- to medium-sized dogs with the Arthrex Canine Cranial Cruciate Ligament Repair Anchor System (CCLRAS). Eighty-five medical records from 2009 to 2012 from 1 institution were evaluated. Complications were classified according to previously proposed definitions for orthopedic studies in veterinary medicine. Fifty-two owners were contacted by telephone at least 6 months after surgery and given a questionnaire to classify complications related to the implant...
August 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Joakim Testuz, Judith Howard, Antonio Pozzi, Ulrich Rytz, Christiane Krudewig, David Spreng, Simone Forterre
OBJECTIVE: To evaluate the usefulness of laser Doppler flowmetry (LDF) to measure surface blood flow in canine cruciate ligaments, compare measurements in different sites of intact and partially ruptured canine cranial cruciate ligaments (CrCL) and intact caudal cruciate ligaments (CaCL), and investigate any association between surface blood flow in partially ruptured CrCL and synovitis or duration of clinical signs. STUDY DESIGN: Case-controlled clinical study...
September 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Veronica J Barkowski, Neil A Embleton
OBJECTIVE: To describe the surgical technique, clinical efficacy, and complications using the Simitri Stable in Stride(®) extracapsular articulating implant (EAI) to treat naturally occurring stifle instability due to cranial cruciate ligament (CrCL) insufficiency. STUDY DESIGN: Prospective case series. ANIMALS: Client-owned dogs with CrCL-deficient stifles (n=60 dogs; 66 stifles). METHODS: An EAI was applied to the medial aspect of the distal femur and proximal tibia after stifle exploration and treatment of joint pathology...
August 2016: Veterinary Surgery: VS
Kwan Kim, Haebeom Lee, Guillaume R Ragetly
OBJECTIVE: To investigate the feasibility of medial meniscal release (MMR) during stifle arthroscopy in toy breed dogs with and without a joint distractor. STUDY DESIGN: Experimental cadaveric study. SAMPLE POPULATION: Stifles (n = 40) from 20 canine cadavers (1.8-5.1 kg). METHODS: Paired stifles were randomly assigned to the joint distractor group and the control group (n = 20 each). All stifles underwent arthroscopic transection of the cranial cruciate ligament followed by a release of the caudomedial meniscotibial ligament...
July 2016: Veterinary Surgery: VS
Shinji Yasukawa, Kazuya Edamura, Koji Tanegashima, Hirotaka Kai, Go Higuchi, Momoyo Nagasawa, Kenji Teshima, Kazushi Asano, Tomohiro Nakayama
The prevalences of displacement and deformity of the medial and lateral fabellae in dogs were investigated. This was a retrospective epidemiologic study. Radiographs of canine stifle joints (1022 limbs, 534 dogs) were obtained. The images were taken at the Nihon University Animal Medical Center and three private animal hospitals from January 2003 to July 2012. The position and morphology of the medial or lateral fabella were evaluated on the radiographs. The prevalence of displacement of the medial and lateral fabellae was 1...
February 2016: Japanese Journal of Veterinary Research
Yalda A Kharaz, Simon R Tew, Mandy Peffers, Elizabeth G Canty-Laird, Eithne Comerford
Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age-related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis. Tissue engineering represents an attractive therapeutic approach to treating T/L injury but it is hampered by our poor understanding of the defining characteristics of the two tissues. The present study aimed to determine differences in the proteomic profile between native T/Ls and tissue engineered (TE) T/L constructs...
May 2016: Proteomics
Gina E Bertocci, Nathan P Brown, Neil A Embleton, Veronica J Barkowski
OBJECTIVE: To evaluate the influence of the Simitri Stable in Stride™ extracapsular articulating implant (EAI) on canine stifle biomechanics in the cranial cruciate ligament (CrCL)-deficient stifle using a 3-dimensional (3D) quasi-static rigid body canine pelvic limb computer model simulating the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Five-year-old neutered male golden retriever (33 kg). METHODS: The EAI was implemented in a previously developed 3D CrCL-deficient canine pelvic limb computer simulation model...
April 2016: Veterinary Surgery: VS
Kohei Murakami, Shingo Maeda, Tomohiro Yonezawa, Naoaki Matsuki
The activity of matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fluids (SF) sampled from dogs with joint disorders was investigated by gelatin zymography and densitometry. Pro-MMP-2 showed similar activity levels in dogs with idiopathic polyarthritis (IPA; n=17) or canine rheumatoid arthritis (cRA; n=4), and healthy controls (n=10). However, dogs with cranial cruciate ligament rupture (CCLR; n=5) presented significantly higher pro-MMP-2 activity than IPA and healthy dogs. Meanwhile, dogs with IPA exhibited significantly higher activity of pro- and active MMP-9 than other groups...
July 1, 2016: Journal of Veterinary Medical Science
Ji Hyun Lee, Farid Badar, John Matyas, Xianggui Qu, Yang Xia
OBJECTIVE: Our aim was to determine topographical variations in zonal properties of articular cartilage over the medial tibia in an experimental osteoarthritis (OA) model using 7-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: An anterior cruciate ligament (ACL)-transection canine model was subjected to study at 8 (six) and 12 (seven) weeks after the surgery. Each medial tibia was divided into five topographical locations. For each specimen, T2 relaxation (at 0° and 55°) was quantified at microscopic resolution...
August 2016: Magma
Patrick A Smith, James P Stannard, Ferris M Pfeiffer, Keiichi Kuroki, Chantelle C Bozynski, James L Cook
PURPOSE: To compare all-inside cortical-button suspensory fixation in sockets versus interference screw fixation in tunnels with respect to clinical, histologic, and biomechanical assessments of all-soft tissue (AST) tendon autografts used for anterior cruciate ligament (ACL) reconstruction in a canine model. METHODS: By use of a validated "hybrid" double-bundle ACL reconstruction technique (reconstruction of the anteromedial bundle with preservation of the native posterolateral bundle), dogs were randomly assigned to undergo either suspensory fixation in sockets (n = 6) or interference screw fixation in tunnels (n = 6)...
June 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Molly Racette, Habib Al saleh, Kenneth R Waller, Jason A Bleedorn, Ronald P McCabe, Ray Vanderby, Mark D Markel, Sabrina H Brounts, Walter F Block, Peter Muir
Estimation of cranial cruciate ligament (CrCL) structural properties in client-owned dogs with incipient cruciate rupture would be advantageous. The objective of this study was to determine whether magnetic resonance imaging (MRI) measurement of normal CrCL volume in an ex-vivo canine model predicts structural properties. Stifles from eight dogs underwent 3.0 Tesla 3D MRI. CrCL volume and normalized median grayscale values were determined using 3D Fast Spin Echo (FSE) Cube and Vastly under-sampled Isotropic PRojection (VIPR)-alternative repetition time (aTR) sequences...
March 2016: Veterinary Journal
Sungho Yun, Sae-Kwang Ku, Young-Sam Kwon
BACKGROUND: The purpose of this study is to investigate the clinical effects of platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cell (MSC) as the fundamental treatment of osteoarthritis (OA). METHODS: Twenty four Beagle dogs were used as cranial cruciate ligament transection models. The dogs were divided into four groups (n = 6) according to the intra-articular injection materials: the control group with phosphate-buffered saline (PBS), the PRP group with PRP, the MSC group with MSCs emerged in PBS, and the MSC and PRP co-treatment (MP) group with MSCs and PRP...
2016: Journal of Orthopaedic Surgery and Research
Chantelle C Bozynski, James P Stannard, Pat Smith, Bryan T Hanypsiak, Keiichi Kuroki, Aaron Stoker, Cristi Cook, James L Cook
The objective of this study was to compare treatment options for acute management of anterior cruciate ligament (ACL) injuries using preclinical models. Twenty-seven adult purpose-bred research hounds underwent knee surgery (sham control, exposed ACL, or partial-tear ACL) and were assessed over the following 8 weeks. Dogs were randomized into three treatment groups: standard of care (i.e., rest and nonsteroidal anti-inflammatory drugs [NSAIDs]), washout, or leukoreduced platelet-rich plasma (PRP) so that a total of nine dogs received each treatment...
December 29, 2015: Journal of Knee Surgery
B Berger, J Knebel, S Steigmeier-Raith, S Reese, A Meyer-Lindenberg
OBJECTIVE: Cranial cruciate ligament rupture is the most frequently occurring disease of the canine stifle. After introduction of corrective osteotomies of the proximal tibia as surgical treatment option in medium, large and giant breeds, the tibial plateau leveling osteotomy (TPLO) evolved into one of the favorite procedures. In the past small breed dogs have usually been treated by extra-articular stabilization techniques. TPLO has recently become an accepted treatment method in these breeds as well as, and is nowadays used with increasing frequency...
2015: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE To investigate the influence of 4 biomechanical parameters on canine cranial cruciate ligament (CrCL)-intact and -deficient stifle joints. SAMPLE Data for computer simulations of a healthy 5-year-old 33-kg neutered male Golden Retriever in a previously developed 3-D rigid body pelvic limb computer model simulating the stance phase during walking. PROCEDURES Canine stifle joint biomechanics were assessed when biomechanical parameters (CrCL stiffness, CrCL prestrain, body weight, and stifle joint friction coefficient) were altered in the pelvic limb computer simulation model...
November 2015: American Journal of Veterinary Research
D J F von Pfeil, J Sung, J Barry, K Hayashi, M R Edwards
OBJECTIVE: To evaluate whether doxycycline administered to dogs with unilateral cranial cruciate ligament rupture (Uni-CCLR) would decrease the risk of contralateral-CCLR (Co-CCLR). To evaluate predictors for Co-CCLR survival. To evaluate if a predisposition of Labrador Retrievers to Co-CCLR exists when compared to other breeds. METHODS: In this prospective randomized controlled clinical trial, 69 client-owned dogs with Uni-CCLR were randomly assigned to a doxycycline (group-D: 7...
2015: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
James L Cook, Patrick A Smith, Chantelle C Bozynski, Keiichi Kuroki, Cristi R Cook, Aaron M Stoker, Ferris M Pfeiffer
Platelet rich plasma (PRP) is used to treat many musculoskeletal disorders. We used a canine model to determine the effects of multiple intra-articular injections of leukoreduced PRP (ACP) on anterior cruciate ligament healing, meniscal healing, and progression of osteoarthritis (OA). With Animal Care and Use Committee (ACUC) approval, 12 dogs underwent partial ACL transection and meniscal release in one knee. At weeks 1, 2, 3, 6, and 8 after insult, dogs were treated with intra-articular injections (2 ml) of either ACP (n = 6) or saline (n = 6)...
April 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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