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Canine Cruciate ligament

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https://www.readbyqxmd.com/read/29573740/posturography-and-dynamic-pedobarography-in-lame-dogs-with-elbow-dysplasia-and-cranial-cruciate-ligament-rupture
#1
José M Carrillo, Maria E Manera, Mónica Rubio, Joaquin Sopena, Angelo Santana, José M Vilar
BACKGROUND: The usefulness of studying posture and its modifications due to locomotor deficiencies of multiple origins has been widely proven in humans. To assess its suitability in the canine species, static posturography and dynamic pedobarography were performed on lame dogs affected with unilateral elbow dysplasia and cranial cruciate ligament rupture by using a pressure platform. With this objective, statokinesiograms and stabilograms, the percentage of pressure distribution between limbs, paw area, mean pressure, and peak pressure, were obtained from lame and sound dogs...
March 24, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29554150/effect-of-leukocyte-reduced-platelet-rich-plasma-on-osteoarthritis-caused-by-cranial-cruciate-ligament-rupture-a-canine-gait-analysis-model
#2
José M Vilar, Maria E Manera, Angelo Santana, Giuseppe Spinella, Oliver Rodriguez, Mónica Rubio, José M Carrillo, Joaquín Sopena, Miguel Batista
The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals...
2018: PloS One
https://www.readbyqxmd.com/read/29525232/why-owners-choose-an-orthosis-over-stifle-surgery-for-canine-cranial-cruciate-ligament-deficiency
#3
Gina E Bertocci, Nathan P Brown, Patrice M Mich
The objective of this study was to describe the patient population of dogs with cranial cruciate ligament (CrCL) deficiency that were prescribed a stifle orthosis. A total of 215 client-owned dogs with previously diagnosed CrCL deficiency were prescribed a stifle orthosis at a veterinary pain management and mobility clinic. Patient intake data collected included dog signalment, chief medical complaint, home environment and activity description, medical and surgical history, and diagnosing veterinarian. An orthopedic examination was conducted to assess pelvic limb function and determine pelvic limb morphologic measures...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29504855/assessment-of-the-effects-of-diet-and-physical-rehabilitation-on-radiographic-findings-and-markers-of-synovial-inflammation-in-dogs-following-tibial-plateau-leveling-osteotomy
#4
Valentine D Verpaalen, Wendy I Baltzer, Sarah Smith-Ostrin, Jennifer J Warnock, Bernadette Stang, Craig G Ruaux
OBJECTIVE To determine the effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy and arthroscopic surgery for treatment of cranial cruciate ligament disease. DESIGN Randomized, prospective clinical trial. ANIMALS 48 dogs with unilateral cranial cruciate ligament disease. PROCEDURES Dogs were randomly assigned to receive a dry omega-3 fatty acid and protein-enriched dog food formulated to support joint health (test food [TF]), a dry food formulated for adult canine maintenance (control food [CF]), TF plus rehabilitation, or CF plus rehabilitation after surgery...
March 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29498035/variations-in-internal-structure-composition-and-protein-distribution-between-intra-and-extra-articular-knee-ligaments-and-tendons
#5
Yalda A Kharaz, Elizabeth G Canty-Laird, Simon R Tew, Eithne J Comerford
Tendons and ligaments play key roles in the musculoskeletal system in both man and animals. Both tissues can undergo traumatic injury, age-related degeneration and chronic disease, causing discomfort, pain and increased susceptibility to wider degenerative joint disease. To date, tendon and ligament ultrastructural biology is relatively under-studied in healthy, non-diseased tissues. This information is essential to understand the pathology of these tissues with regard to function-related injury and to assist with the future development of tissue-engineered tendon and ligament structures...
March 2, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29459502/innovative-intra-articular-prosthetic-technique-for-cranial-cruciate-ligament-reconstruction-in-dogs-a-cadaveric-study
#6
Luca Omini, Stefano Martin, Adolfo Maria Tambella
The purpose of this study was to describe and assess the feasibility of a new intra-articular approach in the treatment of cranial cruciate ligament deficiency in dogs using an artificial ligament and a new bone-anchor system. Twelve canine cadavers weighting 26 to 45 kg were used in this ex-vivo study. Special tibial and femoral screws, two helicoils, and a high resistance artificial fiber compose the implant. Surgery was performed using the mean cranio-lateral approach to the stifle joint. Helicoil and tibial screw, connected to the fiber, were inserted in the center of the tibial insertion area of the cranial cruciate ligament...
February 20, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29440589/intraobserver-and-interobserver-agreement-on-the-radiographical-diagnosis-of-canine-cranial-cruciate-ligament-rupture
#7
Evelien Bogaerts, Elke Van der Vekens, Geert Verhoeven, Hilde de Rooster, Bernadette Van Ryssen, Yves Samoy, Ingrid Putcuyps, Johan Van Tilburg, Nausikaa Devriendt, Frederik Weekers, Mileva Bertal, Blandine Houdellier, Stephanie Scheemaeker, Jeroen Versteken, Maryline Lamerand, Laurien Feenstra, Luc Peelman, Filip Van Nieuwerburgh, Jimmy H Saunders, Bart J G Broeckx
Even though radiography is one of the most frequently used imaging techniques for orthopaedic disorders, it has been demonstrated that the interpretation can vary between assessors. As such, the purpose of this study was to examine the intraobserver and interobserver agreement and the influence of level of expertise on the interpretation of radiographs of the stifle in dogs with and without cranial cruciate ligament rupture (CCLR). Sixteen observers, divided in four groups according to their level of experience, evaluated 30 radiographs (15 cases with CCLR and 15 control stifles) twice...
February 9, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29230875/kinetics-of-plasma-cell-free-dna-and-creatine-kinase-in-a-canine-model-of-tissue-injury
#8
I J Wilson, R K Burchell, A J Worth, S E Burton, K R Gedye, K J Clark, K R Crosse, M Jack, T F Odom, S J De Grey, K M S McGlade, S C Tomlin, N Lopez-Villalobos, A Gal
BACKGROUND: Cell-free DNA (cfDNA) comprises short, double-stranded circulating DNA sequences released from damaged cells. In people, cfDNA concentrations correlate well with disease severity and tissue damage. No reports are available regarding cfDNA kinetics in dogs. OBJECTIVES/HYPOTHESIS: Cell-free DNA will have a short biological half-life and would be able to stratify mild, moderate, and severe tissue injury. Our study aims were to determine the kinetics and biological half-life of cfDNA and to contrast them with those of creatine kinase (CK)...
January 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29202502/variation-in-the-quantity-of-elastic-fibres-with-degeneration-in-canine-cranial-cruciate-ligaments-from-labrador-retrievers
#9
Kinley D Smith, Kei Hayashi, Dylan N Clements, Peter D Clegg, John F Innes, Eithne J Comerford
Objectives  This study aims to quantify numbers of elastic fibres in cranial cruciate ligaments from a dog breed at high risk of cranial cruciate ligament disease. Methods  Macroscopically normal cranial cruciate ligaments were harvested from six Labrador retrievers. Sequential histological sections were assessed for extracellular matrix degeneration (haematoxylin and eosin stain) and elastic fibre staining (Miller's stain). Elastic fibres were semi-quantified using previously published scoring systems...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29125013/diagnostic-value-of-combined-serum-marker-changes-and-quantitative-mri-evaluation-of-cartilage-volume-of-tibial-plateau-in-a-surgically-induced-osteoarthritis-dog-model
#10
Jiangdong Ren, Jinsai Ma, Xiaogang Zhang, Abdusami Aimaiti, Maimaitiming Saiyiti, Yuming Chen, Li Cao
Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29094513/accuracy-of-3-tesla-magnetic-resonance-imaging-using-detection-of-fiber-loss-and-a-visual-analog-scale-for-diagnosing-partial-and-complete-cranial-cruciate-ligament-ruptures-in-dogs
#11
Constance G Fazio, Peter Muir, Susan L Schaefer, Kenneth R Waller
Canine cranial cruciate ligament rupture is often bilateral and asymmetrical, ranging from partial to complete rupture. The purpose of our diagnostic accuracy study was to assess the accuracy of 3 Tesla magnetic resonance imaging (MRI) detection of fiber loss and use of a visual analog scale in the diagnosis of complete versus partial cranial cruciate ligament rupture in 28 clinical dogs with unilateral complete rupture and contralateral partial rupture. Three Tesla MRI was performed on 56 stifles using sagittal sequences (T2-weighted fast spin echo with fat saturation, proton density fast spin echo, and T2-weighted 3D fast spin echo CUBE)...
January 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29064569/a-modified-maquet-tibial-tuberosity-advancement-technique-for-treatment-of-canine-cranial-cruciate-ligament-disease-short-term-outcome-and-complications
#12
Lauren M Retallack, R Mark Daye
OBJECTIVE: To describe and report the outcomes of a novel modified Maquet-tibial tuberosity advancement (mTTA) technique in dogs with naturally occurring cranial cruciate ligament (CCL) rupture, compared to a traditional tibial tuberosity advancement (tTTA) technique. STUDY DESIGN: Descriptive report and retrospective clinical cohort study. SAMPLE POPULATION: Dogs (n = 70) treated via tibial tuberosity advancement (TTA). METHODS: Medical records (2013-2015) of dogs treated for CCL rupture via TTA were reviewed for: signalment, findings on physical examination, procedure (tTTA or mTTA), radiographs, complications, and outcome...
January 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28974260/in-vitro-characterization-of-canine-multipotent-stromal-cells-isolated-from-synovium-bone-marrow-and-adipose-tissue-a-donor-matched-comparative-study
#13
Robert N Bearden, Shannon S Huggins, Kevin J Cummings, Roger Smith, Carl A Gregory, William B Saunders
BACKGROUND: The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived from synovium, bone marrow, and adipose tissue using a donor-matched study design and a comprehensive series of in-vitro characterization, differentiation, and immunomodulation assays...
October 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#14
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na(18)F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28720297/comparison-of-tibial-anatomical-mechanical-axis-angle-between-predisposed-dogs-and-dogs-at-low-risk-for-cranial-cruciate-ligament-rupture
#15
COMPARATIVE STUDY
L Guénégo, M Payot, P Charru, P Verwaerde
The purpose of this prospective, radiographic, descriptive study was to compare measurements of tibial anatomical-mechanical axis angle (AMA-angle), tibial plateau angle (TPA), relative tibial tuberosity width (rTTW) and Z-angle from mediolateral radiographs of the tibia between two canine breeds (72 dogs) not predisposed to cranial cruciate ligament rupture (CCLR) and those from a consecutive series of 185 large dogs and 17 West Highland white terriers (WHWT) diagnosed with unilateral, surgically confirmed CCLR...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28654381/preclinical-multimodal-molecular-imaging-using-18-f-fdg-pet-ct-and-mri-in-a-phase-i-study-of-a-knee-osteoarthritis-in-in-vivo-canine-model
#16
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent (18)F-fluoro-d-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28642867/evaluation-of-the-effect-of-a-single-intra-articular-injection-of-allogeneic-neonatal-mesenchymal-stromal-cells-compared-to-oral-non-steroidal-anti-inflammatory-treatment-on-the-postoperative-musculoskeletal-status-and-gait-of-dogs-over-a-6-month-period-after
#17
Mathieu Taroni, Quentin Cabon, Marine Fèbre, Thibaut Cachon, Nathalie Saulnier, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert, Eric Viguier
OBJECTIVE: Compare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs). STUDY DESIGN: Prospective, double-blinded, randomized, controlled, monocentric clinical study...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28393962/surgical-stabilization-of-concomitant-canine-medial-patellar-luxation-and-cranial-cruciate-ligament-disease-effect-of-fixation-method-on-postoperative-complication-rate-and-clinical-outcome
#18
Albane H Fauron, Mieghan Bruce, Daniel R James, Mark A Owen, Karen L Perry
OBJECTIVES: To compare complication rates and outcomes between cases of concomitant cranial cruciate ligament (CrCL) disease and medial patellar luxation (MPL) treated using extracapsular stabilization and tibial tuberosity transposition (ECS+TTT) and tibial tuberosity transposition and advancement (TTTA). METHODS: In a multicentre retrospective study, records from four referral hospitals were reviewed for dogs with concomitant CrCL pathology and MPL treated using ECS+TTT or TTTA...
May 22, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28369965/canine-cranial-cruciate-ligament-deficient-stifle-biomechanics-associated-with-extra-articular-stabilization-predicted-using-a-computer-model
#19
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE: To evaluate lateral fabellotibial suture (LFTS) and TightRope CCL (TR) extra-articular stabilization biomechanics in the cranial cruciate ligament (CrCL)-deficient canine stifle joint during the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Healthy 33-kg Golden Retriever. METHODS: LFTS and TR were implemented in a previously developed 3-D quasi-static rigid body CrCL-deficient canine pelvic limb computer model simulating the stance phase of gait...
July 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28345997/evaluation-of-a-new-method-to-determine-the-tibial-tuberosity-advancement-distance-required-to-reduce-the-patellar-tendon-tibial-plateau-angle-to-90%C3%A2-with-the-modified-maquet-technique-in-dogs
#20
Paul Pillard, Veronique Livet, Quentin Cabon, Camille Bismuth, Juliette Sonet, Denise Remy, Didier Fau, Claude Carozzo, Eric Viguier, Thibaut Cachon
OBJECTIVE To assess use of a new radiographic method to determine the distance by which the tibial tuberosity should be advanced to reduce the patellar tendon-tibial plateau angle (PTA) to 90° by means of the modified Maquet technique (MMT) in dogs. SAMPLE 24 pelvic limbs from 12 adult medium-sized to large-breed canine cadavers. PROCEDURES Radiographs of stifle joints at 135° extension in true lateral position were used to determine tibial tuberosity advancement distances for use in the MMT. A method was devised to incorporate the planned osteotomy axis; distal patellar translations of 0, 3, 5, or 10 mm; and advancement cage implant application level along the osteotomy site in advancement planning measurements...
April 2017: American Journal of Veterinary Research
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