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https://www.readbyqxmd.com/read/29290418/effect-of-high-intensity-perturbations-during-core-specific-sensorimotor-exercises-on-trunk-muscle-activation
#1
Juliane Mueller, Miralem Hadzic, Hendrik Mugele, Josefine Stoll, Steffen Mueller, Frank Mayer
Core-specific sensorimotor exercises are proven to enhance neuromuscular activity of the trunk. However, the influence of high-intensity perturbations on training efficiency is unclear within this context. Sixteen participants (29±2yrs; 175±8cm; 69±13kg) were prepared with a 12-lead bilateral trunk EMG. Warm-up on a dynamometer was followed by maximum voluntary isometric trunk (flex/ext) contraction (MVC). Next, participants performed four conditions for a one-legged stance with hip abduction on a stable surface (HA) repeated randomly on an unstable surface (HAP), on a stable surface with perturbation (HA+P), and on an unstable surface with perturbation (HAP+P)...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29216707/-femur-fracture-in-a-patient-with-dog-leg-deformity-secondary-to-arthrogryposis-description-of-a-unique-osteosynthesis-method
#2
I Auñón-Martín, V Jiménez-Díaz, J Zorrilla-Sánchez De Neira, A Capel-Agúndez
The concept of arthrogryposis encompasses several conditions that share the presence of multiple congenital contractures. The knee is frequently involved and is an important cause of morbidity in these patients. Flexion contractures of the knee are the most common ones and have a worse prognosis than extension contractures. Different approaches are available to treat flexion contractures of the knee. Distal femoral extension osteotomy effectively corrects fixed flexion, but may lead to residual deformity. This iatrogenic deformity disrupts the anterior convexity of the femoral shaft and leads to serious problems in the subsequent management of orthopedic conditions...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29202501/assessment-of-t2-relaxation-times-for-normal-canine-knee-articular-cartilage-by-t2-mapping-using-1-5-t-magnetic-resonance-imaging
#3
Asami Matsui, Miki Shimizu, Brian Beale, Fumitaka Takahashi, Sinya Yamaguchi
Objectives This study aims to assess and compare the T2 relaxation times for articular cartilage of normal canine stifle joints in four regions by T2 mapping using a 1.5-T magnetic resonance imaging (MRI). Methods In vivo prospective study: 20 hindlimbs (left and right) from 10 normal healthy beagle dogs (n = 20). The region of interest (ROI) was subdivided into medial and lateral condyles of femoral cartilage (MF and LF, respectively) and medial and lateral condyles of tibial cartilage (MT and LT, respectively)...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29125013/diagnostic-value-of-combined-serum-marker-changes-and-quantitative-mri-evaluation-of-cartilage-volume-of-tibial-plateau-in-a-surgically-induced-osteoarthritis-dog-model
#4
Jiangdong Ren, Jinsai Ma, Xiaogang Zhang, Abdusami Aimaiti, Maimaitiming Saiyiti, Yuming Chen, Li Cao
Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29110674/characterization-of-endocannabinoids-and-related-acylethanolamides-in-the-synovial-fluid-of-dogs-with-osteoarthritis-a-pilot-study
#5
Carmela Valastro, Debora Campanile, Mariarosaria Marinaro, Delia Franchini, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo, Antonio Di Bello
BACKGROUND: Cannabis-based drugs have been shown to be effective in inflammatory diseases. A number of endocannabinoids including N- arachidonoylethanolamide (anandamide, AEA) and 2-arachidonyl glycerol (2-AG) with activity at the cannabinoid receptors (CBR) CBR1 and CBR2, have been identified. Other structurally related endogenous fatty acid compounds such as oleoylethanolamide (OEA) and palmitoyl ethanolamide (PEA) have been identified in biological tissues. These compounds do not bind to CBR but might be involved in facilitating the actions of directly acting endocannabinoids and thus are commonly termed "entourage" compounds due to their ability to modulate the endocannabinoid system...
November 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29106743/quantifying-meniscal-kinematics-in-dogs
#6
Brian H Park, Scott A Banks, Antonio Pozzi
The dog has been used extensively as an experimental model to study meniscal treatments such as meniscectomy, meniscal repair, transplantation and regeneration. However, there is very little information on meniscal kinematics in the dog. This study used MR imaging to quantify in vitro meniscal kinematics in loaded dog knees in four distinct poses: extension, flexion, internal and external rotation. A new method was used to track the meniscal poses along the convex and posteriorly tilted tibial plateau. Meniscal displacements were large, displacing 13...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29105014/determination-of-knee-cartilage-volume-and-surface-area-in-beagle-dogs-a-pilot-study
#7
Aad Dhollander, Amanda Malone, James Price, Alan Getgood
BACKGROUND: The objective of this study was to determine the cartilage volume and surface area of male and female Beagle dog knees using 3D (3 dimensional) reconstructed MRI images. METHODS: Six Beagle Dogs (Canis familiaris) (3 males and 3 females) of 10-18 months old and weighing between 7.2 and 17.1 kg underwent a MRI evaluation of both knees. The data acquired allowed a 3D reconstruction of the knee and measurement of the cartilage volume and surface area. RESULTS: Mean knee cartilage volume (averaged over the right and left knees) of animals between 7...
November 6, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28979852/benefits-of-ilizarov-automated-bone-distraction-for-nerves-and-articular-cartilage-in-experimental-leg-lengthening
#8
Nathalia Shchudlo, Tatyana Varsegova, Tatyana Stupina, Michael Shchudlo, Marat Saifutdinov, Andrey Yemanov
AIM: To determine peculiarities of tissue responses to manual and automated Ilizarov bone distraction in nerves and articular cartilage. METHODS: Twenty-nine dogs were divided in two experimental groups: Group M - leg lengthening with manual distraction (1 mm/d in 4 steps), Group A - automated distraction (1 mm/d in 60 steps) and intact group. Animals were euthanized at the end of distraction, at 30(th) day of fixation in apparatus and 30 d after the fixator removal...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28711819/differentiation-potential-of-synoviocytes-derived-from-joints-with-cranial-cruciate-ligament-rupture-and-medial-patella-luxation-in-dogs
#9
H M Suranji Wijekoon, Kazuhide Toyota, Sangho Kim, Jing Fang, Eugene C Bwalya, Kenji Hosoya, Masahiro Okumura
The objective of this study was to assess the differentiation capability of synoviocytes derived from dogs with inflammatory joint conditions. Cranial cruciate ligament ruptured (CCLr) (n=12) and medial patella luxated (MPL) (n=10) knee joints of the dogs were used to collect the synovial membrane (SM). Synoviocytes were enzymatically released from the SM and analyzed by flow cytometry for specific cellular markers (CD44 and CD90) of mesenchymal stem cells (MSCs), while doing histopathology from another part of SM sections...
July 9, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28677167/anterior-femoral-bow-and-possible-effect-on-the-stifle-joint-a-comparison-between-humans-and-dogs
#10
M K Ocal, S S Sabanci, M Cobanoglu, M Enercan
The aim of the study was to compare the anterior bow of the femur between dogs and humans in terms of the possible impact on the stifle joint. The femoral radiographs obtained retrospectively were used to determine the angles and positions of the anterior bow in both dogs (n = 135) and humans (n = 57). Descriptive statistics and Pearson's correlation analysis were used for the statistical analyses of the variables. The mean anterior bow angle (ABA) was 18.3 ± 2.02° and 4.88 ± 1.24° in dogs and humans, respectively...
July 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28669642/compound-posterior-cruciate-ligament-and-popliteal-artery-injury-due-to-dog-bite-a-case-report
#11
Yashwant Singh Tanwar, Atin Jaiswal, Hitesh Lal, Ashok Rajput
Injuries due to dog bites are a common occurrence and are mostly trivial. Severe dog bite injuries requiring hospitalization and complex reconstructive procedures are more common in children. We present the case of a five year old child with popliteal artery thrombosis and compound Posterior Cruciate ligament injury due to a dog bite. The child was managed by immediate thrombectomy, meticulous debridement and knee spanning external fixation followed by Skin Grafting. At one year post surgery range of motion was 10-110°, with no distal neurovascular deficit and no sign of instability...
June 29, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28654381/preclinical-multimodal-molecular-imaging-using-18-f-fdg-pet-ct-and-mri-in-a-phase-i-study-of-a-knee-osteoarthritis-in-in-vivo-canine-model
#12
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent (18)F-fluoro-d-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28427489/effects-of-structural-changes-in-subchondral-bone-on-articular-cartilage-in-a-beagle-dog-model
#13
Dong Yan, Tong Xi Liu, Bao Yue Liu, Ling Wang, Zhan Hua Qian, Xiao Guang Cheng, Kun Cheng Li
OBJECTIVE: Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. METHODS: Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group (n = 12) and a bone cement group (n = 12). Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side...
March 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28145055/manipulated-changes-in-limb-mass-and-rotational-inertia-in-trotting-dogs-canis-lupus-familiaris-and-their-effect-on-limb-kinematics
#14
Brandon M Kilbourne, David R Carrier
While the mass distribution of limbs is known to influence the metabolic energy consumed during locomotion, it remains unknown how the mass distribution of limbs may influence overall limb kinematics and whether the influence of limb mass distribution on limb kinematics differs between fore- and hindlimbs. To examine limb mass distribution's influence upon fore- and hindlimb kinematics, temporal stride parameters and swing phase joint kinematics were recorded from four dogs trotting on a treadmill with 0.5% and 1...
December 2016: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
https://www.readbyqxmd.com/read/28024306/a-canine-arthroscopic-anterior-cruciate-ligament-reconstruction-model-for-study-of-synthetic-augmentation-of-tendon-allografts
#15
James L Cook, Pat Smith, James P Stannard, Ferris Pfeiffer, Keiichi Kuroki, Chantelle C Bozynski, Cristi Cook
Novel graft types, fixation methods, and means for augmenting anterior cruciate ligament (ACL) reconstructions require preclinical validation prior to safe and effective clinical application. The objective of this study was to describe and validate a translational canine model for all-inside arthroscopic complete ACL reconstruction using a quadriceps tendon allograft with internal brace (QTIB). With institutional approval, adult research hounds underwent complete transection of the native ACL followed by all-inside ACL reconstruction using the novel QTIB construct with suspensory fixation (n = 10)...
September 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27739555/evaluation-of-the-relationship-of-tibiofemoral-kinematics-before-and-after-total-knee-replacement-in-an-in-vitro-model-of-cranial-cruciate-deficiency-in-the-dog
#16
Rebecca N Howie, Timothy L Foutz, Curtis C Cathcart, Jeff S Burmeister, Steve C Budsberg
OBJECTIVE: To investigate the relationship between tibiofemoral kinematics before and after total knee replacement (TKR) in vitro. ANIMALS: Eight canine hemipelves. METHODS: A modified Oxford Knee Rig was used to place cadaveric limbs through a range of passive motion allowing the kinematics of the stifle to be evaluated. Four measurements were performed: a control stage, followed by a cranial cruciate transection stage, then following TKR with the musculature intact stage, and finally TKR with removal of limb musculature stage...
November 23, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27648746/does-anterior-cruciate-ligament-innervation-matter-for-joint-function-and-development-of-osteoarthritis
#17
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
May 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27558513/a-one-health-overview-facilitating-advances-in-comparative-medicine-and-translational-research
#18
Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N Bryan, David T Curiel, Hans Rindt, Carol Reinero, Carolyn J Henry, Philip J Bergman, Nicola J Mason, Josephine S Gnanandarajah, Julie B Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne Paterson, Daniel O'Connor, Laura S Treml, James P Stannard, James L Cook, Marc Jacobs, Gerald J Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew Skaff, Amado S Guloy, Harlen D Hays, Amy K LeBlanc, Joan R Coates, Martin L Katz, Leslie A Lyons, Gayle C Johnson, Gary S Johnson, Dennis P O'Brien, Dongsheng Duan, James P Calvet, Barbara Gandolfi, David A Baron, Mark L Weiss, Debra A Webster, Francis N Karanu, Edward J Robb, Robert J Harman
A1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J...
August 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27544345/prosthetic-joint-infection-caused-by-pasteurella-multocida-a-case-series-and-review-of-literature
#19
REVIEW
Estelle Honnorat, Piseth Seng, Hélène Savini, Pierre-Olivier Pinelli, Fabrice Simon, Andreas Stein
BACKGROUND: Pasteurella multocida is a well-recognized zoonotic agent following dog or cat bites or scratches. Nevertheless, prosthetic joint infection caused by P. multocida are rarely reported. METHOD: We report here a series of six cases of prosthetic joint infection caused by P. multocida managed at a referral centre for the treatment of bone and joint infection in southern France. We also reviewed the 26 cases reported in literature. RESULTS: The mean age of our cases was 74 years [±8...
August 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27525982/functional-outcome-measures-in-a-surgical-model-of-hip-osteoarthritis-in-dogs
#20
Dianne Little, Stephen Johnson, Jonathan Hash, Steven A Olson, Bradley T Estes, Franklin T Moutos, B Duncan X Lascelles, Farshid Guilak
BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis...
December 2016: Journal of Experimental Orthopaedics
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