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https://www.readbyqxmd.com/read/27739555/evaluation-of-the-relationship-of-tibiofemoral-kinematics-before-and-after-total-knee-replacement-in-an-in-vitro-model-of-cranial-cruciate-deficiency-in-the-dog
#1
Rebecca N Howie, Timothy L Foutz, Curtis C Cathcart, Jeff S Burmeister, Steve C Budsberg
OBJECTIVE: To investigate the relationship between tibiofemoral kinematics before and after total knee replacement (TKR) in vitro. ANIMALS: Eight canine hemipelves. METHODS: A modified Oxford Knee Rig was used to place cadaveric limbs through a range of passive motion allowing the kinematics of the stifle to be evaluated. Four measurements were performed: a control stage, followed by a cranial cruciate transection stage, then following TKR with the musculature intact stage, and finally TKR with removal of limb musculature stage...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27648746/does-anterior-cruciate-ligament-innervation-matter-for-joint-function-and-development-of-osteoarthritis
#2
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27558513/a-one-health-overview-facilitating-advances-in-comparative-medicine-and-translational-research
#3
Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N Bryan, David T Curiel, Hans Rindt, Carol Reinero, Carolyn J Henry, Philip J Bergman, Nicola J Mason, Josephine S Gnanandarajah, Julie B Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne Paterson, Daniel O'Connor, Laura S Treml, James P Stannard, James L Cook, Marc Jacobs, Gerald J Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew Skaff, Amado S Guloy, Harlen D Hays, Amy K LeBlanc, Joan R Coates, Martin L Katz, Leslie A Lyons, Gayle C Johnson, Gary S Johnson, Dennis P O'Brien, Dongsheng Duan, James P Calvet, Barbara Gandolfi, David A Baron, Mark L Weiss, Debra A Webster, Francis N Karanu, Edward J Robb, Robert J Harman
A1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J...
August 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27544345/prosthetic-joint-infection-caused-by-pasteurella-multocida-a-case-series-and-review-of-literature
#4
Estelle Honnorat, Piseth Seng, Hélène Savini, Pierre-Olivier Pinelli, Fabrice Simon, Andreas Stein
BACKGROUND: Pasteurella multocida is a well-recognized zoonotic agent following dog or cat bites or scratches. Nevertheless, prosthetic joint infection caused by P. multocida are rarely reported. METHOD: We report here a series of six cases of prosthetic joint infection caused by P. multocida managed at a referral centre for the treatment of bone and joint infection in southern France. We also reviewed the 26 cases reported in literature. RESULTS: The mean age of our cases was 74 years [±8...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27525982/functional-outcome-measures-in-a-surgical-model-of-hip-osteoarthritis-in-dogs
#5
Dianne Little, Stephen Johnson, Jonathan Hash, Steven A Olson, Bradley T Estes, Franklin T Moutos, B Duncan X Lascelles, Farshid Guilak
BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27445744/emotional-availability-modulates-electrophysiological-correlates-of-executive-functions-in-preschool-children
#6
Henriette Schneider-Hassloff, Annabel Zwönitzer, Anne K Künster, Carmen Mayer, Ute Ziegenhain, Markus Kiefer
Executive functions (EFs) - a set of cognitive control abilities - mediate resilience to stress and are associated with academic achievement and health throughout life. They are crucially linked to prefrontal cortex function as well as to other cortical and subcortical brain functions, which are maturing throughout childhood at different rates. Recent behavioral research suggested that children's EFs were related to parenting quality and child attachment security, but the neural correlates of these associations are unknown...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27432274/elevated-synovial-fluid-concentration-of-adenosine-triphosphate-in-dogs-with-osteoarthritis-or-sodium-urate-induced-synovitis-of-the-stifle
#7
Bryan T Torres, David A Jimenez, Steven C Budsberg
Adenosine triphosphate has been shown to stimulate nociceptive nerve terminals in joints. Elevated synovial fluid adenosine triphosphate concentrations as well as a correlation between synovial fluid adenosine triphosphate concentrations and osteoarthritic knee pain has been demonstrated in humans, but not yet in dogs. This study documented elevated synovial fluid adenosine triphosphate concentrations in the stifles of dogs with secondary osteoarthritis and urate-induced synovitis, as compared to normal stifles...
July 19, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27358284/fresh-osteochondral-allograft-versus-autograft-twelve-month-results-in-isolated-canine-knee-defects
#8
Eric C McCarty, Ryan R Fader, Justin J Mitchell, R Edward Glenn, Hollis G Potter, Kurt P Spindler
BACKGROUND: Osteochondral autografts and allografts have been widely used in the treatment of isolated grade 4 articular cartilage lesions of the knee. However, there is a paucity of literature regarding the basic science investigating the direct comparison between fresh osteochondral allografts to autografts. HYPOTHESIS: At 12 months, fresh osteochondral allografts are equal to autografts with respect to function, bony incorporation into host bone, and chondrocyte viability...
September 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27255741/notochordal-cell-conditioned-medium-nccm-regenerates-end-stage-human-osteoarthritic-articular-chondrocytes-and-promotes-a-healthy-phenotype
#9
Sebastian Müller, Lina Acevedo, Xiaomei Wang, M Zia Karim, Ajay Matta, Arne Mehrkens, Stefan Schaeren, Sandra Feliciano, Marcel Jakob, Ivan Martin, Andrea Barbero, W Mark Erwin
BACKGROUND: Notochordal cell conditioned medium (NCCM) derived from non-chondrodystrophic dogs has pro-anabolic and anti-catabolic effects upon nucleus pulposus (NP) cells. Here, for the first time, we assessed the ability of NCCM to influence the production of extracellular matrix and inflammatory proteins by healthy and osteoarthritic human chondrocytes within engineered cartilage tissues. We hypothesized that, similar to its action on NP cells, NCCM exerts metabolic and anti-catabolic effects on human articular chondrocytes and has the potential to significantly counteract inflammatory mediators...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27102292/evaluation-of-a-silver-impregnated-coating-to-inhibit-colonization-of-orthopaedic-implants-by-biofilm-forming-methicillin-resistant-staphylococcus-pseudintermedius
#10
Mohammed A Azab, Matthew J Allen, Joshua B Daniels
OBJECTIVES: To evaluate the in vitro antibacterial activity of a silver-impregnated coating against a biofilm-forming strain of methicillin-resistant Staphylococcus pseudintermedius (MRSP). METHODS: A clinical MRSP isolate sourced from a failed canine knee implant was evaluated for biofilm production and used in the present study. Using a standard test method and a clinically approved titanium substrate, the antimicrobial activity of a novel silver plasma coating was determined at two times: five minutes after inoculation of the specimens (T0) and after 24 hours of incubation (T24)...
July 19, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27080933/determination-of-joint-loads-using-new-sensate-scaffolds-for-regenerating-large-cartilage-defects-in-the-knee
#11
John A Szivek, John T Ruth, Greg J Heden, Michael A Martinez, Nicklaus H Diggins, Karl H Wenger
Two complete unicondylar surface replacement scaffold designs to support tissue-engineered cartilage growth that utilized adult endogenous stem cells were 3D printed and tested in a dog stifle model. Integrated rosette strain gauges were calibrated and used to determine shear loading within stifle joints for up to 12 months. An activity index that compared extent of daily activity with tissue formation showed differences in the extent and quality of new tissue with the most active animal having the most new tissue formation...
April 15, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27049029/comparative-lipidomic-analysis-of-synovial-fluid-in-human-and-canine-osteoarthritis
#12
M K Kosinska, S C Mastbergen, G Liebisch, J Wilhelm, R B Dettmeyer, B Ishaque, M Rickert, G Schmitz, F P Lafeber, J Steinmeyer
OBJECTIVE: The lipid profile of synovial fluid (SF) is related to the health status of joints. The early stages of human osteoarthritis (OA) are poorly understood, which larger animals are expected to be able to model closely. This study examined whether the canine groove model of OA represents early OA in humans based on the changes in the lipid species profile in SF. Furthermore, the SF lipidomes of humans and dogs were compared to determine how closely canine lipid species profiles reflect the human lipidome...
August 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/26920431/importance-of-donor-chondrocyte-viability-for-osteochondral-allografts
#13
James L Cook, James P Stannard, Aaron M Stoker, Chantelle C Bozynski, Keiichi Kuroki, Cristi R Cook, Ferris M Pfeiffer
BACKGROUND: Osteochondral allograft (OCA) transplantation provides a biological treatment option for functional restoration of large articular cartilage defects in multiple joints. While successful outcomes after OCA transplantation have been linked to viable donor chondrocytes, the importance of donor cell viability has not been comprehensively validated. PURPOSE: To use a canine model to determine the importance of donor chondrocyte viability at the time of implantation with respect to functional success of femoral condylar OCAs based on radiographic, gross, cell viability, histologic, biochemical, and biomechanical outcome measures...
May 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26867692/hyaluronic-acid-versus-saline-intra-articular-injections-for-amelioration-of-chronic-knee-osteoarthritis-a-canine-model
#14
Troy D Pashuck, Keiichi Kuroki, Cristi R Cook, Aaron M Stoker, James L Cook
The objective of this study was to assess the safety and efficacy of intra-articular injections of hyaluronic acid (HA) versus saline for symptomatic treatment of osteoarthritis (OA). Twenty-five adult purpose-bred dogs underwent meniscal release of one knee. Clinical, arthroscopic and radiographic signs of OA were confirmed in all dogs prior to treatment. Dogs were randomized into 5 groups: HA-1 (n = 5), HA-3 (n = 5), HA-5 (n = 5), Saline-1 (n = 5) and Saline-3 (n = 5). Each dog received intra-articular injections of the respective substance into the affected knee at the pre-determined time points...
February 11, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/26865768/impact-of-10-weeks-of-yoga-practice-on-flexibility-and-balance-of-college-athletes
#15
M Jay Polsgrove, Brandon M Eggleston, Roch J Lockyer
BACKGROUND: With clearer evidence of its benefits, coaches, and athletes may better see that yoga has a role in optimizing performance. AIMS: To determine the impact of yoga on male college athletes (N = 26). METHODS: Over a 10-week period, a yoga group (YG) of athletes (n = 14) took part in biweekly yoga sessions; while a nonyoga group (NYG) of athletes (n = 12) took part in no additional yoga activity. Performance measures were obtained immediately before and after this period...
January 2016: International Journal of Yoga
https://www.readbyqxmd.com/read/26853947/suspensory-versus-interference-screw-fixation-for-arthroscopic-anterior-cruciate-ligament-reconstruction-in-a-translational-large-animal-model
#16
Patrick A Smith, James P Stannard, Ferris M Pfeiffer, Keiichi Kuroki, Chantelle C Bozynski, James L Cook
PURPOSE: To compare all-inside cortical-button suspensory fixation in sockets versus interference screw fixation in tunnels with respect to clinical, histologic, and biomechanical assessments of all-soft tissue (AST) tendon autografts used for anterior cruciate ligament (ACL) reconstruction in a canine model. METHODS: By use of a validated "hybrid" double-bundle ACL reconstruction technique (reconstruction of the anteromedial bundle with preservation of the native posterolateral bundle), dogs were randomly assigned to undergo either suspensory fixation in sockets (n = 6) or interference screw fixation in tunnels (n = 6)...
June 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/26713594/acute-management-of-anterior-cruciate-ligament-injuries-using-novel-canine-models
#17
Chantelle C Bozynski, James P Stannard, Pat Smith, Bryan T Hanypsiak, Keiichi Kuroki, Aaron Stoker, Cristi Cook, James L Cook
The objective of this study was to compare treatment options for acute management of anterior cruciate ligament (ACL) injuries using preclinical models. Twenty-seven adult purpose-bred research hounds underwent knee surgery (sham control, exposed ACL, or partial-tear ACL) and were assessed over the following 8 weeks. Dogs were randomized into three treatment groups: standard of care (i.e., rest and nonsteroidal anti-inflammatory drugs [NSAIDs]), washout, or leukoreduced platelet-rich plasma (PRP) so that a total of nine dogs received each treatment...
December 29, 2015: Journal of Knee Surgery
https://www.readbyqxmd.com/read/26568857/leukocyte-and-platelet-rich-plasma-l-prp-versus-leukocyte-and-platelet-rich-fibrin-l-prf-for-articular-cartilage-repair-of-the-knee-a-comparative-evaluation-in-an-animal-model
#18
Davoud Kazemi, Ashraf Fakhrjou
BACKGROUND: Articular cartilage injuries of the knee are among the most debilitating injuries leading to osteoarthritis due to limited regenerative capability of cartilaginous tissue. The use of platelet concentrates containing necessary growth factors for cartilage healing has recently emerged as a new treatment method. OBJECTIVES: The efficacy of two types of different platelet concentrates were compared in the treatment of acute articular cartilage injuries of the knee in an animal model...
October 2015: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/26403590/multiple-injections-of-leukoreduced-platelet-rich-plasma-reduce-pain-and-functional-impairment-in-a-canine-model-of-acl-and-meniscal-deficiency
#19
James L Cook, Patrick A Smith, Chantelle C Bozynski, Keiichi Kuroki, Cristi R Cook, Aaron M Stoker, Ferris M Pfeiffer
Platelet rich plasma (PRP) is used to treat many musculoskeletal disorders. We used a canine model to determine the effects of multiple intra-articular injections of leukoreduced PRP (ACP) on anterior cruciate ligament healing, meniscal healing, and progression of osteoarthritis (OA). With Animal Care and Use Committee (ACUC) approval, 12 dogs underwent partial ACL transection and meniscal release in one knee. At weeks 1, 2, 3, 6, and 8 after insult, dogs were treated with intra-articular injections (2 ml) of either ACP (n = 6) or saline (n = 6)...
April 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/26286930/vascular-pythiosis-of-the-lower-extremity-in-northern-thailand-ten-years-experience
#20
Termpong Reanpang, Saritphat Orrapin, Saranat Orrapin, Supapong Arworn, Thanate Kattipatanapong, Tanop Srisuwan, Nongnuch Vanittanakom, Suree P Lekawanvijit, Kittipan Rerkasem
Pythiosis is a disease caused by Pythium insidiosum, a fungus-like organism. P. insidiosum is pathogenic in mammals, particularly in horses, dogs, and humans. Human pythiosis can be classified into 4 types: (1) cutaneous/subcutaneous, (2) ocular, (3) vascular, and (4) disseminated pythiosis. Vascular pythiosis is a rare disease but a serious limb- and life-threatening infection. We reviewed 22 cases over a 10-year period in Maharaj Nakorn Chiang Mai/Chiang Mai University Hospital. The survival rate was around 63...
September 2015: International Journal of Lower Extremity Wounds
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