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https://www.readbyqxmd.com/read/29900517/mesenchymal-stem-cells-in-osteotomy-repair-after-tibial-tuberosity-advancement-in-dogs-with-cranial-cruciate-ligament-injury
#1
Clarissa Rocha Dos Santos, Richard da Rocha Filgueiras, Patrícia Furtado Malard, Andre Rodrigues da Cunha Barreto-Vianna, Kaique Nogueira, Carolina da Silva Leite, Eduardo Maurício Mendes de Lima
BACKGROUND: The cranial cruciate ligament rupture (CCLR) is the most commonly encountered orthopedic condition in dogs. Among the various techniques to treat this condition, tibial tuberosity advancement (TTA) has been used to obtain rapid recovery of the affected knee. The objective of this study was to evaluate the viability of the use of mesenchymal stem cells (MSC) implanted in the osteotomy site obtained by TTA in nine dogs diagnosed with CCLR. METHODS: The MSC were isolated from the adipose tissue of the dogs and cultured for eight days, the animals were divided into two groups...
June 14, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29895307/kinematic-adaptions-to-induced-short-term-pelvic-limb-lameness-in-trotting-dogs
#2
Birte Goldner, Stefanie Fischer, Ingo Nolte, Nadja Schilling
BACKGROUND: Lameness due to paw injuries is common in the clinical practice. Although many studies investigated gait adaptations to diseases or injuries, mainly of the hip and knee, our understanding of the biomechanical coping mechanisms that lame dogs utilize is limited. Therefore, this study evaluated the kinematic changes associated with an induced, load-bearing pelvic limb lameness in healthy dogs trotting on a treadmill. Kinematic analysis included spatio-temporal comparisons of limb, joint and segment angles of all limbs...
June 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29861739/evaluation-of-the-curative-effect-of-umbilical-cord-mesenchymal-stem-cell-therapy-for-knee-arthritis-in-dogs-using-imaging-technology
#3
Bei-Ying Zhang, Bing-Yun Wang, Shao-Chuan Li, Dong-Zhang Luo, Xiaoshu Zhan, Sheng-Feng Chen, Zhi-Sheng Chen, Can-Ying Liu, Hui-Qin Ji, Yin-Shan Bai, Dong-Sheng Li, Yang He
Objective: The aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs. Methods: Eight dogs were evenly assigned to two groups. The canine model of knee osteoarthritis was established by surgical manipulation of knee articular cartilage on these eight dogs. UC-MSCs were isolated from umbilical cord Wharton's jelly by 0.1% type collagenase I and identified by immunofluorescence staining and adipogenic and osteogenic differentiation in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29852514/intra-articular-biocompatibility-of-multistranded-long-chain-polyethylene-suture-tape-in-a-canine-acl-model
#4
Patrick A Smith, Chantelle C Bozynski, Keiichi Kuroki, Sarah M Henrich, Coen A Wijdicks, James L Cook
The purpose of this study was to assess intra-articular use of a nonabsorbable braided suture tape for its biocompatibility when implanted adjacent to the native anterior cruciate ligament (ACL) in a canine model. Establishing biocompatibility of suture tape in the knee is an important foundational step for clinicians considering use of suture tape augmentation for ACL reconstruction or repair. The study hypothesis was that a nonabsorbable braided suture tape would be biocompatible in the knee with no resultant adverse functional consequences, and no significant intra-articular synovial reactions or articular cartilage degeneration attributable to direct exposure to the suture tape, whether intact or transected...
May 31, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29748965/subchondroplasty-for-the-treatment-of-post-traumatic-bone-marrow-lesions-of-the-medial-femoral-condyle-in-a-pre-clinical-canine-model
#5
Olubusola A Brimmo, Chantelle C Bozynski, Cristi R Cook, Keiichi Kuroki, Seth L Sherman, Ferris M Pfeiffer, Aaron M Stoker, James L Cook
This study characterizes long-term outcomes associated with subchondroplasty (SCP) treatment for impact-induced subchondral bone marrow lesions (BML) using a validated pre-clinical canine model. With IACUC approval, purpose-bred research hounds (n = 16) underwent arthroscopic impact injury (40N) to both medial femoral condyles. At 3 months, functional assessments, arthroscopy and MRI were performed and knees (n = 32) were randomly assigned to SCP (3 mL fluoroscopically guided percutaneous injection of AccuFill BSM into BML bone defects) or sham injection (Control)...
May 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29713636/the-pathobiology-of-the-meniscus-a-comparison-between-the-human-and-dog
#6
REVIEW
Olga Krupkova, Lucas Smolders, Karin Wuertz-Kozak, James Cook, Antonio Pozzi
Serious knee pain and related disability have an annual prevalence of approximately 25% on those over the age of 55 years. As curative treatments for the common knee problems are not available to date, knee pathologies typically progress and often lead to osteoarthritis (OA). While the roles that the meniscus plays in knee biomechanics are well characterized, biological mechanisms underlying meniscus pathophysiology and roles in knee pain and OA progression are not fully clear. Experimental treatments for knee disorders that are successful in animal models often produce unsatisfactory results in humans due to species differences or the inability to fully replicate disease progression in experimental animals...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29702719/evaluation-of-a-novel-degradable-synthetic-biomaterial-patch-for-augmentation-of-tendon-healing-in-a-large-animal-model
#7
Wayne K Gersoff, Chantelle C Bozynski, Cristi R Cook, Ferris M Pfeiffer, Keiichi Kuroki, James L Cook
Tendon injury is common in sports. The standard of care (SOC) for tendon repair is surgical treatment. However, restored tendons often lack complete strength and functionality, and surgical repair is often unsuccessful. This controlled laboratory study investigates the healing of an Artelon patch (AP)-augmented tendon versus tendon repair alone in a preclinical canine patellar tendon defect model. Full-thickness proximal and distal flap defects were created in the patella tendons of eight purpose-bred research mongrel dogs...
April 27, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29679952/injuries-to-cyclists-due-to-a-dog-bicycle-interaction
#8
Randall T Loder, Alan P Yaacoub
BACKGROUND:  Both dogs and bicycles are common in our society and thus a dog-bicycle interaction resulting in an injury to a cyclist is possible. It was the purpose of this study to investigate such injuries. METHODS:  The National Electronic Injury Surveillance System (NEISS) data for the 10-year period from 2006 through 2015 associated with bicycles were accessed. Injuries involving dogs were identified and the mechanism of injury determined. Due to the stratified and weighted nature of the NEISS data, statistical analyses were performed with SUDAAN 10 software (RTI International, Research Triangle Park, North Carolina, United States)...
May 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29560390/diagnosis-of-streptococcus-canis-periprosthetic-joint-infection-the-utility-of-next-generation-sequencing
#9
Majd Tarabichi, Abtin Alvand, Noam Shohat, Karan Goswami, Javad Parvizi
A 62-year-old man who had undergone a primary knee arthroplasty 3 years earlier, presented to the emergency department with an infected prosthesis. He underwent prosthesis resection. All cultures failed to identify the infecting organism. Analysis of the intraoperative samples by next-generation sequencing revealed Streptococcus canis (an organism that resides in the oral cavity of dogs). It was later discovered that the patient had sustained a dog scratch injury several days earlier. The patient reports that his dog had licked the scratch...
March 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/29514315/chemical-neurolysis-of-the-genicular-nerves-for-chronic-knee-pain-reviving-an-old-dog-and-an-old-trick
#10
David R Walega, Zachary L McCormick
No abstract text is available yet for this article.
March 5, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29290418/effect-of-high-intensity-perturbations-during-core-specific-sensorimotor-exercises-on-trunk-muscle-activation
#11
Juliane Mueller, Miralem Hadzic, Hendrik Mugele, Josefine Stoll, Steffen Mueller, Frank Mayer
Core-specific sensorimotor exercises are proven to enhance neuromuscular activity of the trunk. However, the influence of high-intensity perturbations on training efficiency is unclear within this context. Sixteen participants (29±2yrs; 175±8cm; 69±13kg) were prepared with a 12-lead bilateral trunk EMG. Warm-up on a dynamometer was followed by maximum voluntary isometric trunk (flex/ext) contraction (MVC). Next, participants performed four conditions for a one-legged stance with hip abduction on a stable surface (HA) repeated randomly on an unstable surface (HAP), on a stable surface with perturbation (HA+P), and on an unstable surface with perturbation (HAP+P)...
March 21, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29216707/-femur-fracture-in-a-patient-with-dog-leg-deformity-secondary-to-arthrogryposis-description-of-a-unique-osteosynthesis-method
#12
I Auñón-Martín, V Jiménez-Díaz, J Zorrilla-Sánchez De Neira, A Capel-Agúndez
The concept of arthrogryposis encompasses several conditions that share the presence of multiple congenital contractures. The knee is frequently involved and is an important cause of morbidity in these patients. Flexion contractures of the knee are the most common ones and have a worse prognosis than extension contractures. Different approaches are available to treat flexion contractures of the knee. Distal femoral extension osteotomy effectively corrects fixed flexion, but may lead to residual deformity. This iatrogenic deformity disrupts the anterior convexity of the femoral shaft and leads to serious problems in the subsequent management of orthopedic conditions...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29202501/assessment-of-t2-relaxation-times-for-normal-canine-knee-articular-cartilage-by-t2-mapping-using-1-5-t-magnetic-resonance-imaging
#13
COMPARATIVE STUDY
Asami Matsui, Miki Shimizu, Brian Beale, Fumitaka Takahashi, Sinya Yamaguchi
Objectives  This study aims to assess and compare the T2 relaxation times for articular cartilage of normal canine stifle joints in four regions by T2 mapping using a 1.5-T magnetic resonance imaging (MRI). Methods   In vivo prospective study: 20 hindlimbs (left and right) from 10 normal healthy beagle dogs ( n  = 20). The region of interest (ROI) was subdivided into medial and lateral condyles of femoral cartilage (MF and LF, respectively) and medial and lateral condyles of tibial cartilage (MT and LT, respectively)...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29125013/diagnostic-value-of-combined-serum-marker-changes-and-quantitative-mri-evaluation-of-cartilage-volume-of-tibial-plateau-in-a-surgically-induced-osteoarthritis-dog-model
#14
Jiangdong Ren, Jinsai Ma, Xiaogang Zhang, Abdusami Aimaiti, Maimaitiming Saiyiti, Yuming Chen, Li Cao
Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29110674/characterization-of-endocannabinoids-and-related-acylethanolamides-in-the-synovial-fluid-of-dogs-with-osteoarthritis-a-pilot-study
#15
Carmela Valastro, Debora Campanile, Mariarosaria Marinaro, Delia Franchini, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo, Antonio Di Bello
BACKGROUND: Cannabis-based drugs have been shown to be effective in inflammatory diseases. A number of endocannabinoids including N- arachidonoylethanolamide (anandamide, AEA) and 2-arachidonyl glycerol (2-AG) with activity at the cannabinoid receptors (CBR) CBR1 and CBR2, have been identified. Other structurally related endogenous fatty acid compounds such as oleoylethanolamide (OEA) and palmitoyl ethanolamide (PEA) have been identified in biological tissues. These compounds do not bind to CBR but might be involved in facilitating the actions of directly acting endocannabinoids and thus are commonly termed "entourage" compounds due to their ability to modulate the endocannabinoid system...
November 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29106743/quantifying-meniscal-kinematics-in-dogs
#16
Brian H Park, Scott A Banks, Antonio Pozzi
The dog has been used extensively as an experimental model to study meniscal treatments such as meniscectomy, meniscal repair, transplantation, and regeneration. However, there is very little information on meniscal kinematics in the dog. This study used MR imaging to quantify in vitro meniscal kinematics in loaded dog knees in four distinct poses: extension, flexion, internal, and external rotation. A new method was used to track the meniscal poses along the convex and posteriorly tilted tibial plateau. Meniscal displacements were large, displacing 13...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29105014/determination-of-knee-cartilage-volume-and-surface-area-in-beagle-dogs-a-pilot-study
#17
Aad Dhollander, Amanda Malone, James Price, Alan Getgood
BACKGROUND: The objective of this study was to determine the cartilage volume and surface area of male and female Beagle dog knees using 3D (3 dimensional) reconstructed MRI images. METHODS: Six Beagle Dogs (Canis familiaris) (3 males and 3 females) of 10-18 months old and weighing between 7.2 and 17.1 kg underwent a MRI evaluation of both knees. The data acquired allowed a 3D reconstruction of the knee and measurement of the cartilage volume and surface area. RESULTS: Mean knee cartilage volume (averaged over the right and left knees) of animals between 7...
November 6, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28979852/benefits-of-ilizarov-automated-bone-distraction-for-nerves-and-articular-cartilage-in-experimental-leg-lengthening
#18
Nathalia Shchudlo, Tatyana Varsegova, Tatyana Stupina, Michael Shchudlo, Marat Saifutdinov, Andrey Yemanov
AIM: To determine peculiarities of tissue responses to manual and automated Ilizarov bone distraction in nerves and articular cartilage. METHODS: Twenty-nine dogs were divided in two experimental groups: Group M - leg lengthening with manual distraction (1 mm/d in 4 steps), Group A - automated distraction (1 mm/d in 60 steps) and intact group. Animals were euthanized at the end of distraction, at 30(th) day of fixation in apparatus and 30 d after the fixator removal...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28711819/differentiation-potential-of-synoviocytes-derived-from-joints-with-cranial-cruciate-ligament-rupture-and-medial-patella-luxation-in-dogs
#19
H M Suranji Wijekoon, Kazuhide Toyota, Sangho Kim, Jing Fang, Eugene C Bwalya, Kenji Hosoya, Masahiro Okumura
The objective of this study was to assess the differentiation capability of synoviocytes derived from dogs with inflammatory joint conditions. Cranial cruciate ligament ruptured (CCLr) (n=12) and medial patella luxated (MPL) (n=10) knee joints of the dogs were used to collect the synovial membrane (SM). Synoviocytes were enzymatically released from the SM and analyzed by flow cytometry for specific cellular markers (CD44 and CD90) of mesenchymal stem cells (MSCs), while doing histopathology from another part of SM sections...
October 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28677167/anterior-femoral-bow-and-possible-effect-on-the-stifle-joint-a-comparison-between-humans-and-dogs
#20
COMPARATIVE STUDY
M K Ocal, S S Sabanci, M Cobanoglu, M Enercan
The aim of the study was to compare the anterior bow of the femur between dogs and humans in terms of the possible impact on the stifle joint. The femoral radiographs obtained retrospectively were used to determine the angles and positions of the anterior bow in both dogs (n = 135) and humans (n = 57). Descriptive statistics and Pearson's correlation analysis were used for the statistical analyses of the variables. The mean anterior bow angle (ABA) was 18.3 ± 2.02° and 4.88 ± 1.24° in dogs and humans, respectively...
August 2017: Anatomia, Histologia, Embryologia
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