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https://www.readbyqxmd.com/read/28428105/microcarcinoid-arising-in-patients-with-long-standing-ulcerative-colitis-histological-analysis
#1
Sachie Kanada, Akira Sugita, Tetuo Mikami, Kenichi Ohashi, Hiroyuki Hayashi
Some case reports of neuroendocrine tumors (NETs) and neuroendocrine carcinoma (NEC) associated with ulcerative colitis (UC) have been published. Most NET cases are small lesions corresponding to microcarcinoids (MCs). However, published case reports have presented findings of MCs as single-case reports. Thus, the frequency of MCs is still unclear. In this study, we described the clinical and morphological features of 14 cases of UC-associated MC and estimated the frequency of MC. Consecutive patients with UC who underwent complete removal of the large intestine were assessed, and 135 patients were selected...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28425943/beneficial-effect-of-voluntary-exercise-on-experimental-colitis-in-mice-fed-a-high-fat-diet-the-role-of-irisin-adiponectin-and-proinflammatory-biomarkers
#2
Agnieszka Irena Mazur-Bialy, Jan Bilski, Dagmara Wojcik, Bartosz Brzozowski, Marcin Surmiak, Magdalena Hubalewska-Mazgaj, Anna Chmura, Marcin Magierowski, Katarzyna Magierowska, Tomasz Mach, Tomasz Brzozowski
Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn's disease and ulcerative colitis. Although the aetiology of IBD is unknown, several factors coming from the adipose tissue and skeletal muscles, such as cytokines, adipokines and myokines, were suggested in the pathogenesis of ulcerative colitis; however, it has not been extensively studied whether voluntary exercise can ameliorate that disorder. We explored the effect of moderate exercise (i...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28420140/oleuropein-decreases-cyclooxygenase-2-and-interleukin-17-expression-and-attenuates-inflammatory-damage-in-colonic-samples-from-ulcerative-colitis-patients
#3
Tiziana Larussa, Manuela Oliverio, Evelina Suraci, Marta Greco, Roberta Placida, Serena Gervasi, Raffaella Marasco, Maria Imeneo, Donatella Paolino, Luigi Tucci, Elio Gulletta, Massimo Fresta, Antonio Procopio, Francesco Luzza
Oleuropein (OLE) is the major phenolic secoiridoid of olive tree leaves, and its antioxidant and anti-inflammatory activities have been demonstrated in in vitro and in vivo animal models. The aim of this study was to investigate the activity of OLE in the colonic mucosa from patients with ulcerative colitis (UC). Biopsies obtained during colonoscopy from 14 patients with active UC were immediately placed in an organ culture chamber and challenged with lipopolysaccharide from Escherichia coli (EC-LPS) at 1 μg/mL in the presence or absence of 3 mM OLE...
April 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28373409/activation-of-tgf-%C3%AE-activated-kinase-1-promotes-colon-mucosal-pathogenesis-in-inflammatory-bowel-disease
#4
Zhiwei Liu, Fansheng Kong, Jefferson E Vallance, Eleana Harmel-Laws, Surya Amarachintha, Kris A Steinbrecher, Michael J Rosen, Sandip Bhattacharyya
The etiology and mechanisms for inflammatory bowel disease (IBD) are incompletely known. Determination of new, clinically important mechanisms for intestinal inflammation is imperative for developing effective therapies to treat IBD We sought to define a widespread mechanism for colon mucosal inflammation via the activation of TGF-β activated Kinase 1 (TAK1), a central regulator of cellular inflammatory actions. Activation of TAK1 and the downstream inflammatory signaling mediators was determined in pediatric patients with ulcerative colitis (UC) or Crohn's disease (CD) as well as in DSS-induced and spontaneous IBD in mice...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28361841/effects-of-humanin-on-experimental-colitis-induced-by-2-4-6-trinitrobenzene-sulphonic-acid-in-rats
#5
Fatma A Gultekin, Ali U Emre, Sevim K Celik, Figen Barut, Ufuk Tali, Demet Sumer, Ummuhani O Turkcu
BACKGROUND/AIM: The excessive apoptosis of intestinal epithelial cells (IECs) partly accounts for the development of colonic inflammation and eventually results in ulcerative colitis (UC). Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. The present study aimed to investigate the effects of glysin variant of humanin (HNG) on 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats...
March 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28351778/the-effect-of-theophylline-on-acetic-acid-induced-ulcerative-colitis-in-rats
#6
Masoumeh Ghasemi-Pirbaluti, Ehsan Motaghi, Ali Najafi, Mohammad Javad Hosseini
BACKGROUND: Ulcerative colitis is a relapsing inflammatory disorder of the colon. There is a need to explore the new treatments for this disorder. Theophylline, a competitive inhibitor of phosphodiesterase, is shown to have anti-inflammatory properties. However, the effect of theophylline on ulcerative colitis has not yet been investigated. The present study evaluated the effect of theophylline on acetic acid induced ulcerative colitis in rats. MATERIALS AND METHODS: Colitis was induced by instillation of 2ml of acetic acid solution (3%)...
March 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28350750/family-history-comorbidity-smoking-and-other-risk-factors-in-microscopic-colitis-a-case-control-study
#7
Anna Wickbom, Nils Nyhlin, Scott M Montgomery, Johan Bohr, Curt Tysk
OBJECTIVES: Data on heredity, risk factors and comorbidity in microscopic colitis, encompassing collagenous colitis (CC) and lymphocytic colitis (LC), are limited. AIM: The aim was to carry out a case-control study of family history, childhood circumstances, educational level, marital status, smoking and comorbidity in microscopic colitis. METHODS: A postal questionnaire was sent in 2008-2009 to microscopic colitis patients resident in Sweden and three population-based controls per patient, matched for age, sex and municipality...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28347506/antidepressant-associated-microscopic-colitis-a-case-report-and-literature-review
#8
Thomas G Salter, Mark D Williams
No abstract text is available yet for this article.
January 19, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28337639/the-impact-of-mangiferin-from-belamcanda-chinensis-on-experimental-colitis-in-rats
#9
Marta Szandruk, Anna Merwid-Ląd, Adam Szeląg
BACKGROUND: Inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)] constitutes an important clinical problem. The pathogenesis of IBD remains unclear. It is believed that immune dysfunction, inflammatory mediators and oxidative damage play crucial roles in development of IBD. The condition is clinically associated with symptoms ranging from mild to severe during relapses, depending on the affected segment of the gastrointestinal tract. Bloody diarrhea with mucus, abdominal pain, weight loss and anemia are initial symptoms of both CD and UC...
March 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28328627/extended-release-multimatrix-budesonide-for-microscopic-colitis
#10
Amrit K Kamboj, Thomas G Cotter, S Bradley Hicks, William J Tremaine, Edward V Loftus, Darrell S Pardi
No abstract text is available yet for this article.
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28300788/protective-effect-of-protocatechuic-acid-on-tnbs-induced-colitis-in-mice-is-associated-with-modulation-of-the-sphk-s1p-signaling-pathway
#11
Irene Crespo, Beatriz San-Miguel, José Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González-Gallego
(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS. PCA (30 or 60 mg/kg body wt) was given intraperitoneally daily for five days; (3) Results: Administration of PCA prevented the macroscopic and microscopic damage to the colonic mucosa, the decrease in body weight gain and the increase in myeloperoxidase activity induced by TNBS...
March 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28275312/clinical-and-immunologic-effects-of-faecal-microbiota-transplantation-in-a-patient-with-collagenous-colitis
#12
Sezin Günaltay, Lech Rademacher, Elisabeth Hultgren Hörnquist, Johan Bohr
One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28267639/evaluation-of-anti-inflammatory-effect-of-silver-coated-glass-beads-in-mice-with-experimentally-induced-colitis-as-a-new-type-of-treatment-in-inflammatory-bowel-disease
#13
Krzysztof Siczek, Hubert Zatorski, Anna Chmielowiec-Korzeniowska, Radzisław Kordek, Leszek Tymczyna, Jakub Fichna
BACKGROUND: Recent studies point at the anti-inflammatory action of silver through induction of apoptosis of inflammatory cells via oxidative stress, promotion of wound healing as well as antimicrobial effect. Our aim was to design a new formulation based on silver and validate its anti-inflammatory activity in the mouse models of colitis. METHODS: Silver-coated glass beads were prepared using a magnetron sputtering method and a standard magnetron sputtering gun equipped with pure silver target...
January 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28265892/current-approach-to-the-evaluation-and-management-of-microscopic-colitis
#14
REVIEW
Thomas G Cotter, Darrell S Pardi
PURPOSE OF REVIEW: Microscopic colitis is a common cause of chronic watery diarrhea, particularly in the elderly. The accompanying symptoms, which include abdominal pain and fatigue, can markedly impair patients' quality of life. Diagnosis is based upon characteristic histologic findings of the colonic mucosa. This review focuses on the current approach to evaluation and management of patients with microscopic colitis. RECENT FINDINGS: Although the incidence of microscopic colitis has been increasing over time, recent epidemiological studies show stabilization at 21...
February 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28246536/effects-of-herb-partitioned-moxibustion-on-the-mirna-expression-profiles-in-colon-from-rats-with-dss-induced-ulcerative-colitis
#15
Yan Huang, Zhe Ma, Yun-Hua Cui, Hong-Sheng Dong, Ji-Meng Zhao, Chuan-Zi Dou, Hui-Rong Liu, Jing Li, Huan-Gan Wu
Objective. This study explored the mechanism of herb-partitioned moxibustion (HM) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) from the miRNA perspective. Methods. Rats were randomly divided into 3 groups [normal control (NC) group, UC model (UC) group, and herb-partitioned moxibustion (UCHM) group]. The UC and UCHM groups were administered 4% DSS for 7 days. The UCHM group received HM at the Tianshu (bilateral, ST25). The effect of HM on UC was observed and the miRNA expression profile in the colon tissues was analyzed...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28244237/usefulness-of-confocal-laser-endomicroscopy-to-diagnose-ulcerative-colitis-associated-neoplasia
#16
Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Dai Yoshida, Hyuga Yamada, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda
Chromoendoscopy, narrow-band imaging (NBI), and confocal laser endomicroscopy (CLE) have been introduced in ulcerative colitis (UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we performed probe-based CLE (pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI...
February 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28215538/over-90-of-cases-of-microscopic-colitis-can-be-diagnosed-by-performing-a-short-colonoscopy
#17
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Jean François Boivin, Bruno Lesgourgues, Mathieu Yver, Laurent Costes, I Abd Alsamad, Joel Cucherousset, Claire Charpignon, Hélène Guyot, Bénédicte Lambaré, Jean-Michel Ghilain, Valérie Calès, Stéphanie de Montigny-Lenhardt, Guy Bellaïche, Alexandre Pariente, Stéphane Nahon
AIMS: To determinate the topographical distribution of key diagnostic histological features of lymphocytic colitis (LC) and collagenous colitis (CC) and to establish what correlations may exist between the histological findings and the causes and severity of MC. PATIENTS AND METHODS: Patients with MC were included in a prospective multicentre French study from September 2010 to October 2012. MC was diagnosed by performing total colonoscopy with multiple biopsies of the rectum and colon collected in separate jars and analyzed separately for each site (descending and sigmoid colon, transverse colon, ascending colon)...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28175211/p720-use-of-proton-pump-inhibitors-associated-with-a-markedly-increased-risk-of-microscopic-colitis
#18
O Bonderup, G Lauge Nielsen, M Dall, A Pottegård, J Hallas
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175032/p234-recent-trends-in-microscopic-colitis-demographics-clinical-features-and-outcomes-in-a-portuguese-cohort
#19
M Silva, A Peixoto, S Lopes, A C-R Nunes, F Magro, G Macedo
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173087/p696-ambient-air-quality-as-risk-factor-for-microscopic-colitis-a-geographic-information-system-study
#20
B P M Verhaegh, E M Beijnens, T R A van den Heuvel, D Goudkade, M P Zeegers, T S Nawrot, A A M Masclee, D M A E Jonkers, M J Pierik
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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