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colitis microscopic

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https://www.readbyqxmd.com/read/28215538/over-90-of-cases-of-microscopic-colitis-can-be-diagnosed-by-performing-a-short-colonoscopy
#1
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Jean François Boivin, Bruno Lesgourgues, Mathieu Yver, Laurent Costes, I Abd Alsamad, Joel Cucherousset, Claire Charpignon, Hélène Guyot, Bénédicte Lambaré, Jean-Michel Ghilain, Valérie Calès, Stéphanie de Montigny-Lenhardt, Guy Bellaïche, Alexandre Pariente, Stéphane Nahon
AIMS: To determinate the topographical distribution of key diagnostic histological features of lymphocytic colitis (LC) and collagenous colitis (CC) and to establish what correlations may exist between the histological findings and the causes and severity of MC. PATIENTS AND METHODS: Patients with MC were included in a prospective multicentre French study from September 2010 to October 2012. MC was diagnosed by performing total colonoscopy with multiple biopsies of the rectum and colon collected in separate jars and analyzed separately for each site (descending and sigmoid colon, transverse colon, ascending colon)...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28175211/p720-use-of-proton-pump-inhibitors-associated-with-a-markedly-increased-risk-of-microscopic-colitis
#2
O Bonderup, G Lauge Nielsen, M Dall, A Pottegård, J Hallas
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175032/p234-recent-trends-in-microscopic-colitis-demographics-clinical-features-and-outcomes-in-a-portuguese-cohort
#3
M Silva, A Peixoto, S Lopes, A C-R Nunes, F Magro, G Macedo
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173087/p696-ambient-air-quality-as-risk-factor-for-microscopic-colitis-a-geographic-information-system-study
#4
B P M Verhaegh, E M Beijnens, T R A van den Heuvel, D Goudkade, M P Zeegers, T S Nawrot, A A M Masclee, D M A E Jonkers, M J Pierik
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172765/p737-early-life-microbial-exposure-lifestyle-and-comorbidity-as-risk-factors-for-microscopic-colitis-a%C3%A2-case-control-study
#5
B P M Verhaegh, D M A E Jonkers, M J Pierik, A A M Masclee, D Goudkade
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172750/op016-potential-role-of-bile-acid-receptor-fxr-in-microscopic-colitis
#6
C Palmela, J Torres, P Gomes de Sena, M P Costa Santos, C Gouveia, M H Oliveira, C M P Rodrigues, M Cravo, P Borralho
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172605/p713-possible-explanations-of-the-marked-differences-in-the-incidence-of-microscopic-colitis-between-denmark-and-sweden
#7
S Davidson, L Munck, L Vigren, P Engel, K Sjöberg
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168580/the-incidence-of-microscopic-colitis-microscopic-no-more
#8
EDITORIAL
Nicole M Gentile, Eugene F Yen
No abstract text is available yet for this article.
February 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28159515/local-enema-treatment-to-inhibit-folh1-gcpii-as-a-novel-therapy-for-inflammatory-bowel-disease
#9
Abhijit A Date, Rana Rais, Taarika Babu, Jairo Ortiz, Pranjali Kanvinde, Ajit G Thomas, Sarah C Zimmermann, Alexandra J Gadiano, Gilad Halpert, Barbara S Slusher, Laura M Ensign
Here we evaluate the potential for local administration of a small molecule FOLH1/GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) as a novel treatment for inflammatory bowel disease (IBD). We found that FOLH1/GCPII enzyme activity was increased in the colorectal tissues of mice with TNBS-induced colitis, and confirmed that 2-PMPA inhibited FOLH1/GCPII enzyme activity ex vivo. In order to maximize local enema delivery of 2-PMPA, we studied the effect of vehicle tonicity on the absorption of 2-PMPA in the colon...
January 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28138449/budesonide-related-iatrogenic-cushing-s-syndrome-in-microscopic-colitis
#10
Kartikeya Tripathi, Thomas Dunzendorfer
Budesonide is the treatment of choice for microscopic colitis because of its excellent risk to benefit ratio. It is a potent, well-absorbed corticosteroid, but because of a high rate of first-pass metabolism in the liver, its systemic bioavailability is low. It has fewer corticosteroid-related adverse effects than prednisone, and adrenal suppression is considered to be rare. We present a middle-aged woman with lymphocytic colitis whose symptoms responded to budesonide but developed budesonide-related iatrogenic Cushing's syndrome...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28128877/endoscopic-findings-of-ipilimumab-induced-colitis
#11
Tatsunori Satoh, Kazuya Ohno, Takafumi Kurokami
Ipilimumab is a fully humanized monoclonal antibody targeting inhibitory cytotoxic T-lymphocyte-associated antigen-4 on T cells, thereby enhancing antitumor immunity.(1) While ipilimumab has significant therapeutic benefit, it induces hypersensitivity reactions in some targeted organs. Ipilimumab-induced colitis (IiC) is one such hypersensitivity reaction, clinically manifesting as colitis.(2) Colonoscopy is helpful in diagnosing IiC. The macroscopic and microscopic features of IiC include friable erythematous mucosa and ulcers with an absent vascular pattern...
January 27, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28121001/anti-inflammatory-effects-of-dioscorea-alata-l-anthocyanins-in-a-tnbs-induced-colitis-model
#12
Tao Chen, Shihui Hu, Haiwen Zhang, Qingfeng Guan, Yuhui Yang, Xuemei Wang
The purple yam, Dioscorea alata L., is an important source of starch, vitamins and polyphenols. Five different pigments from the purple tubers of this plant were separated by high-performance liquid chromatography-mass spectrometry, and the anthocyanin fraction (DACN) was collected. The anti-inflammatory effects of DACNs were investigated at different concentrations and compared with the standard colitis treatment, 5-aminosalicylic acid, in a trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model. Macro- and microscopic parameters including body weight change, disease activity index (DAI) and intestinal histology were used for the determination of the anti-inflammatory effects of DACNs...
January 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28119938/pseudomembranous-collagenous-colitis-a-case-of-not-so-microscopic-colitis
#13
Douglas Grunwald, Manisha Mehta, Sunil G Sheth
We present a 72-year-old male who developed progressive, watery diarrhea despite anti-motility agents. On colonoscopy, the mucosa was inflamed and covered with an exudate. Stool studies for Clostridium difficile and Escherichia coli were negative. Biopsies revealed pseudomembranous collagenous colitis, a rare form of microscopic colitis. His symptoms improved dramatically with budesonide therapy.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28101837/drug-exposure-and-the-risk-of-microscopic-colitis-a-critical-update
#14
Alfredo J Lucendo
A variety of luminal antigens, including a wide range of drugs, have been associated with the still little-known pathophysiology of microscopic colitis (MC), with variable evidence suggesting causality. This article aims to review the aspects related to drugs as potential triggers of MC; to discuss the most commonly identified associations between drugs and MC; and to analyze the limitations of the studies currently available. A literature search was performed in PubMed combining the search terms 'drug exposure', 'drug consumption', and 'risk factors' with 'microscopic colitis', 'lymphocytic colitis', and 'collagenous colitis', with no language restrictions...
January 18, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28070826/interaction-of-ethnicity-and-h-pylori-infection-in-the-occurrence-of-microscopic-colitis
#15
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies found that microscopic colitis is inversely associated with Helicobacter pylori infection and that microscopic colitis is characterized by a marked ethnic variation. AIM: The aim of the present study was to test whether an underlying ethnic variation of H. pylori infection is responsible for the ethnic variation of microscopic colitis. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA...
January 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28062871/-chronic-diarrhea-in-the-diabetic-a-review-of-the-literature
#16
Juan Sebastián Frías Ordoñez, William Otero Regino
The association of diarrhea with diabetes mellitus has been known for more than 70 years. In diabetic patients its prevalence is around 20%.Its clinical manifestations are diverse, and represents a diagnostic and therapeutic challenge.There are certain diagnoses of higher prevalence in diabetic patients than in the general population.The different related etiologies can be adequately diagnosed through the clinical history and complementary diagnostic tests.The medications used by the diabetic patient to manage their disease often cause chronic diarrhea, so the pharmacological background should be studied at the time of the study of diarrhea...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28050038/continuing-medical-education-questions-january-2017-diagnosis-and-management-of-microscopic-colitis
#17
REVIEW
Steven L Carpenter
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28050030/continuing-medical-education-january-2017-diagnosis-and-management-of-microscopic-colitis
#18
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28044228/reduced-il-37-production-increases-spontaneous-chemokine-expressions-in-colon-epithelial-cells
#19
Sezin Günaltay, Mohammed Ghiboub, Olof Hultgren, Elisabeth Hultgren Hörnquist
BACKGROUND AND AIM: Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is a common cause of chronic diarrhea. Previously, we showed enhanced chemokine productions in microscopic colitis patients, indicating dysregulated immune cell chemotaxis in the immunopathogenesis. We also showed decreased mRNA of IL-37, mainly regarded as an anti-inflammatory cytokine, in the colonic mucosa of these patients, potentially an important factor for the chronicity of the colitis...
January 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28040845/the-effect-of-sodium-valproate-on-acetic-acid-induced-colitis-in-rats
#20
Ali Najafi, Ehsan Motaghi, Mohammad Javad Hosseini, Masoumeh Ghasemi-Pirbaluti
Ulcerative colitis is a chronic recurrent disease with incomplete treatment options. The current article evaluated the effect of sodium valproate on acetic acid-induced ulcerative colitis in rats. Rats were randomly distributed into six groups including Sham group, colitis control group, sodium valproate treatment groups (50, 100 and 300 mg/kg, i.p.) and dexamethasone-treatment group. Dexamethasone was used as a reference drug. Colitis was induced by intracolonic instillation of 2 mL of 3% acetic acid solution...
February 2017: Inflammopharmacology
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