Jamie L Inman, Yulun Wu, Liang Chen, Ella Brydon, Dhruba Ghosh, Kenneth H Wan, Jared De Chant, Lieselotte Obst-Huebl, Kei Nakamura, Corie Y Ralston, Susan E Celniker, Jian-Hua Mao, Peter H Zwart, Hoi-Ying N Holman, Hang Chang, James B Brown, Antoine M Snijders
Non-invasive methods of detecting radiation exposure show promise to improve upon current approaches to biological dosimetry in ease, speed, and accuracy. Here we developed a pipeline that employs Fourier transform infrared (FTIR) spectroscopy in the mid-infrared spectrum to identify a signature of low dose ionizing radiation exposure in mouse ear pinnae over time. Mice exposed to 0.1 to 2 Gy total body irradiation were repeatedly measured by FTIR at the stratum corneum of the ear pinnae. We found significant discriminative power for all doses and time-points out to 90 days after exposure...
March 13, 2024: Scientific Reports