keyword
MENU ▼
Read by QxMD icon Read
search

Total body irradiation

keyword
https://www.readbyqxmd.com/read/29140165/improved-total-body-irradiation-survival-by-delivery-of-two-radiation-mitigators-that-target-distinct-cell-death-pathways
#1
Justin Steinman, Michael Epperly, Wen Hou, John Willis, Hong Wang, Renee Fisher, Bing Liu, Ivet Bahar, Travis McCaw, Valerian Kagan, Hulya Bayir, Jian Yu, Peter Wipf, Song Li, M Saiful Huq, Joel S Greenberger
The acute lethality of total-body irradiation (TBI) involves damage to multiple organs, including bone marrow and intestine. Ionizing radiation mitigators that are effective when delivered 24 h or later after TBI include the anti-apoptotic drug, JP4-039 and the anti-necroptotic drug, necrostatin-1. In contrast to effective delivery of JP4-039 at 24 h after TBI, necrostatin-1 is most effective when delivery is delayed until 48 h, a time that correlates with the elevation of necroptosis-inducing inflammatory cytokines and necroptosis-induced serine phosphorylation of receptor-interacting serine/threonine-protein kinase-3 (RIP3) in tissues...
November 15, 2017: Radiation Research
https://www.readbyqxmd.com/read/29125446/suprasellar-and-recurrent-pediatric-craniopharyngiomas-expanding-indications-for-the-extended-endoscopic-transsphenoidal-approach
#2
Andrew F Alalade, Elizabeth Ogando-Rivas, Jerome Boatey, Mark M Souweidane, Vijay K Anand, Jeffrey P Greenfield, Theodore H Schwartz
OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility in younger children, in recurrent and irradiated tumors, and in masses primarily located in the suprasellar region. The narrow corridor, incomplete pneumatization, and fear of hypothalamic injury have traditionally relegated this approach to application in older children with mostly cystic craniopharyngiomas centered in the sella...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29125192/long-term-outcomes-among-2-year-survivors-of-autologous-hematopoietic-cell-transplantation-for-hodgkin-and-diffuse-large-b-cell-lymphoma
#3
Regina M Myers, Brian T Hill, Bronwen E Shaw, Soyoung Kim, Heather R Millard, Minoo Battiwalla, Navneet S Majhail, David Buchbinder, Hillard M Lazarus, Bipin N Savani, Mary E D Flowers, Anita D'Souza, Matthew J Ehrhardt, Amelia Langston, Jean A Yared, Robert J Hayashi, Andrew Daly, Richard F Olsson, Yoshihiro Inamoto, Adriana K Malone, Zachariah DeFilipp, Steven P Margossian, Anne B Warwick, Samantha Jaglowski, Amer Beitinjaneh, Henry Fung, Kimberly A Kasow, David I Marks, Jana Reynolds, Keith Stockerl-Goldstein, Baldeep Wirk, William A Wood, Mehdi Hamadani, Prakash Satwani
BACKGROUND: Autologous hematopoietic cell transplantation (auto-HCT) is a standard therapy for relapsed classic Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL); however, long-term outcomes are not well described. METHODS: This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression-free for ≥2 years after auto-HCT for cHL or DLBCL between 1990 and 2008. The median age at auto-HCT was 40 years; the median follow-up was 10...
November 10, 2017: Cancer
https://www.readbyqxmd.com/read/29121114/cd4-levels-control-the-odds-of-induction-of-humoral-immune-responses-to-tracer-doses-of-therapeutic-antibodies
#4
Sharat Srinivasula, Erin Gabriel, Insook Kim, Paula DeGrange, Alexis St Claire, Candace Mallow, Robert E Donahue, Chang Paik, H C Lane, Michele Di Mascio
Rapidly increasing number of therapeutic antibodies are being repurposed to imaging probes for noninvasive diagnosis, as well as monitoring during treatment or disease recurrence. Though antibody-based imaging involves tracer doses (~3 log lower than therapeutic doses), and immune responses are severely reduced in patients with impaired immunity, formation of anti-tracer antibodies (ATA) has been observed hampering further diagnostic monitoring. Here, we explored the potential to develop humoral responses to intravenously administered tracer dose of a monoclonal antibody F(ab΄)2 fragment, and associated with host related immune measures in 49 rhesus macaques categorized into healthy (uninfected controls), SIV-progressors, SIV non-progressors, or total body irradiated (TBI)...
2017: PloS One
https://www.readbyqxmd.com/read/29100905/post-transplant-cyclophosphamide-ptcy-as-sole-gvhd-prophylaxis-is-feasible-in-patients-undergoing-peripheral-blood-stem-cell-transplantation-for-severe-aplastic-anaemia-using-matched-sibling-donors
#5
Biju George, Nisham Pn, Anup J Devasia, Uday Kulkarni, Anu Korula, Kavitha M Lakshmi, Aby Abraham, Alok Srivastava, Vikram Mathews
High-dose cyclophosphamide (PTCY) following allogeneic hematopoietic cell transplantation (HSCT) has been shown to be effective in preventing graft-versus-host disease (GVHD) following HLA-matched bone marrow transplantation. We performed a phase II study of PTCY given at 50 mg/kg IV on days 3 and 4 as sole GVHD prophylaxis following HSCT for severe aplastic anemia (SAA) receiving G-CSF-mobilized peripheral blood stem cell (PBSC) grafts from HLA-matched related donors following conditioning with fludarabine, cyclophosphamide and single dose Total Body Irradiation (TBI)...
October 31, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29097738/pharmacologically-induced-reversible-hypometabolic-state-mitigates-radiation-induced-lethality-in-mice
#6
Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Jharna Ray, Prem Kumar Indraganti
Therapeutic hypothermia has proven benefits in critical care of a number of diseased states, where inflammation and oxidative stress are the key players. Here, we report that adenosine monophosphate (AMP) triggered hypometabolic state (HMS), 1-3 hours after lethal total body irradiation (TBI) for a duration of 6 hours, rescue mice from radiation-induced lethality and this effect is mediated by the persistent hypothermia. Studies with caffeine and (6)N-cyclohexyladenosine, a non-selective antagonist and a selective agonist of adenosine A1 receptor (A1AR) respectively, indicated the involvement of adenosine receptor (AR) signaling...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095431/double-versus-single-intensive-phototherapy-with-leds-in-treatment-of-neonatal-hyperbilirubinemia
#7
M L Donneborg, P K Vandborg, B M Hansen, M Rodrigo-Domingo, F Ebbesen
OBJECTIVE: We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes. STUDY DESIGN: Eighty-three infants with gestational age ⩾33 weeks and uncomplicated hyperbilirubinemia were randomized to either double (n=41) or single phototherapy (n=42) for 24 h. The mean irradiance was 64.8 μW cm(-2) nm(-1) from above and 39 μW cm(-2) nm(-1) from below...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29082594/verification-of-junction-dose-between-vmat-arcs-of-total-body-irradiation-using-a-sun-nuclear-arccheck-phantom
#8
Colm T Morrison, Kirsty L Symons, Simon J Woodings, Michael J House
A volumetric modulated arc therapy (VMAT) approach to total body irradiation (TBI) has recently been introduced at our institution. The planning target volume (PTV) is divided into separate sub-volumes, each being treated with 2 arcs with their own isocentre. Pre-treatment quality assurance of beams is performed on a Sun Nuclear ArcCHECK diode array. Measurement of junction regions between VMAT arcs with separate isocentres has previously been performed with point dose ionization chamber measurements, or with films...
October 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29082212/impact-of-prolonged-fraction-delivery-time-modelling-stereotactic-body-radiation-therapy-with-high-dose-hypofractionation-on-the-killing-of-cultured-achn-renal-cell-carcinoma-cell-line
#9
M Khorramizadeh, A Saberi, Ma Tahmasebi-Birgani, P Shokrani, A Amouhedari
INTRODUCTION: Stereotactic body radiotherapy delivers hypofractionated irradiation with high dose per fraction through complex treatment techniques. The increased complexity leads to longer dose delivery times for each fraction. The purpose of this study is to investigate the impact of prolonged fraction delivery time with high-dose hypofractionation on the killing of cultured ACHN cells. METHODS AND MATERIALS: The radiobiological characteristics and repair half-time of human ACHN renal cell carcinoma cell line were studied with clonogenic assays...
September 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29079283/consolidative-radiotherapy-after-autologous-stem-cell-transplantation-for-relapsed-or-refractory-diffuse-large-b-cell-lymphoma
#10
Brendan G Coutu, Christopher T Wilke, Jianling Yuan, Qing Cao, Matthew R Vernon, Chung Lee, Veronika Bachanova, Kathryn E Dusenbery
INTRODUCTION: We evaluated the role of consolidative radiotherapy (RT) for patients undergoing high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). MATERIALS AND METHODS: We reviewed the medical records of 72 consecutive patients who had undergone ASCT for relapsed or refractory DLBCL at our institution from 2006 to 2014. Pretransplant conditioning consisted of HDC and total body irradiation...
September 20, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29063809/thoracic-gamma-irradiation-induced-obesity-in-c57bl-6-female-mice
#11
Steven B Zhang, Shanmin Yang, Zhenhuan Zhang, Amy Zhang, Mei Zhang, Liangjie Yin, Katherine Casey-Sawicki, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff
PURPOSE: To investigate the late effects of thoracic region irradiation (TRI) on mouse body weight. MATERIALS AND METHODS: Female C57BL/6 mice were divided into nonirradiated, 5 Gy total body irradiation, 9 Gy sub-total body irradiation, and 12.5 Gy thoracic region irradiation (TRI) groups. Changes in mouse weight were monitored every other week at similar time points for 12 months. The anatomical characteristics of abdominal visceral fat distribution were recorded, and mitochondrial DNA copy number in the hearts and livers and lipid metabolic signaling in the liver were analyzed...
October 24, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29061536/total-body-irradiation-is-safe-and-similarly-effective-to-chemotherapy-only-conditioning-in-autologous-stem-cell-transplantation-for-mantle-cell-lymphoma-patients
#12
Yolanda D Tseng, Philip A Stevenson, Ryan D Cassaday, Andrew Cowan, Brian G Till, Mazyar Shadman, Solomon A Graf, Ralph Ermoian, Stephen D Smith, Leona A Holmberg, Oliver W Press, Ajay K Gopal
Autologous stem cell transplant (ASCT) consolidation has become a standard approach for patients with mantle cell lymphoma (MCL), yet there is little consensus on the role of total body irradiation (TBI) as part of high-dose transplant conditioning. We analyzed 75 consecutive MCL patients that underwent ASCT at our institution between 2001-2011 with either TBI-based (n=43) or carmustine, etoposide, cytarabine, melphalan (n=32; BEAM) high-dose conditioning. Most patients (97%) had chemosensitive disease and were transplanted in first remission (89%)...
October 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29037020/factors-associated-with-pulmonary-toxicity-after-myeloablative-conditioning-using-fractionated-total-body-irradiation
#13
Hwa Kyung Byun, Hong In Yoon, Jaeho Cho, Hyun Ju Kim, Yoo Hong Min, Chuhl Joo Lyu, June-Won Cheong, Jin Seok Kim, Hyo Sun Kim, Soo-Jeong Kim, Andrew Jihoon Yang, Byung Min Lee, Won Hee Lee, Joongyo Lee, Ki Jung Ahn, Chang-Ok Suh
PURPOSE: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. MATERIALS AND METHODS: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035281/young-endothelial-cells-revive-aging-blood
#14
Vivian Y Chang, Christina M Termini, John P Chute
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice...
October 16, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29024236/mesenchymal-stromal-cell-derived-extracellular-vesicles-provide-long-term-survival-after-total-body-irradiation-without-additional-hematopoietic-stem-cell-support
#15
Jill-Sandra Schoefinius, Bärbel Brunswig-Spickenheier, Thomas Speiseder, Sabrina Krebs, Ursula Just, Claudia Lange
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived mesenchymal stromal cells (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The transplantation of mMSC-derived EV into lethally irradiated mice resulted in long-term survival but no improvement in short-term reconstitution of the recipients. Importantly, the radiation rescue was efficient without additional hematopoietic support...
October 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/28993922/100%C3%A2-kgy-gamma-affected-microbial-communities-within-the-ancient-arctic-permafrost-under-simulated-martian-conditions
#16
Vladimir S Cheptsov, Elena A Vorobyova, Natalia A Manucharova, Mikhail V Gorlenko, Anatoli K Pavlov, Maria A Vdovina, Vladimir N Lomasov, Sergey A Bulat
This research aimed to investigate the viability and biodiversity of microbial communities within ancient Arctic permafrost after exposure to a gamma-radiation dose of 100 kGy at low temperature (- 50 °C), low pressure (1 Torr) and dehydration conditions. The main objective was to assess the possibility for long-term survival of Earth-bound microorganisms in the subsurface of Martian regolith or inside small space bodies at constant absorption and accumulation of the gamma radiation dose. Investigated microbial communities had shown high resistance to a simulated Martian environment...
November 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28993772/rescuing-self-transient-isolation-and-autologous-transplantation-of-bone-marrow-mitigates-radiation-induced-hematopoietic-syndrome-and-mortality-in-mice
#17
Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Prem Kumar Indraganti
The inflamed bone marrow niche shortly after total body irradiation (TBI) is known to contribute to loss of hematopoietic stem cells in terms of their number and function. In this study, autologous bone marrow transfer (AL-BMT) was evaluated as a strategy for mitigating hematopoietic form of the acute radiation syndrome by timing the collection phase (2 h after irradiation) and reinfusion (24 h after irradiation) using mice as a model system. Collection of bone marrow (BM) cells (0.5 × 10(6) total marrow cells) 2 h after lethal TBI rescued different subclasses of hematopoietic stem and progenitor cells (HSPCs) from the detrimental inflammatory and damaging milieu in vivo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28988743/fludarabine-based-reduced-intensity-regimen-for-matched-related-donor-hematopoietic-stem-cell-transplantation-in-acquired-severe-aplastic-anemia
#18
K M Ghanem, M A Kharfan-Dabaja, H El-Solh, N Harris, N Kreidieh, R Nehme, S A Muwakkit, R Saab, A Bazarbachi, M R Abboud
Different conditioning regimens have been evaluated in matched-related donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acquired severe aplastic anemia (SAA) with varying results. In this manuscript, we report our experience with fludarabine (120mg/m(2)), very low dose cyclophosphamide (1200mg/m(2)) and antithymocyte globulin (7.5mg/kg). Low dose total body irradiation (2Gy) was added to the conditioning regimen for patients older than 15 years. Nineteen patients (median age 23years) underwent transplant between 2008 and 2015...
September 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28988422/comparison-of-two-cytoreductive-regimens-for-%C3%AE-%C3%AE-t-cell-depleted-haploidentical-hsct-in-pediatric-malignancies-improved-engraftment-and-outcome-with-tbi-based-regimen
#19
Elad Jacoby, Nira Varda-Bloom, Gal Goldstein, Daphna Hutt, Chaim Churi, Helly Vernitsky, Amos Toren, Bella Bielorai
BACKGROUND: Graft manipulation using selective depletion of αβ-T cells provides a source of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) enriched in effector cells. We report our experience implementing this haplo-HSCT for high-risk malignancies in pediatric patients focusing on the conditioning regimen. PROCEDURE: We performed a retrospective study of patients who underwent T-cell receptor αβ-depleted haplo-HSCT for high-risk pediatric malignancies...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28985133/organ-doses-associated-with-partial-body-irradiation-with-2-5-bone-marrow-sparing-of-the-non-human-primate-a-retrospective-study
#20
C Prado, T J MacVittie, A W Bennett, A Kazi, A M Farese, K Prado
A partial-body irradiation model with approximately 2.5% bone marrow sparing (PBI/BM2.5) was established to determine the radiation dose-response relationships for the prolonged and delayed multi-organ effects of acute radiation exposure. Historically, doses reported to the entire body were assumed to be equal to the prescribed dose at some defined calculation point, and the dose-response relationship for multi-organ injury has been defined relative to the prescribed dose being delivered at this point, e.g...
October 6, 2017: Radiation Research
keyword
keyword
5515
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"