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Total body irradiation

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https://www.readbyqxmd.com/read/28545017/12-o-tetradecanoylphorbol-13-acetate-tpa-increases-murine-intestinal-crypt-stem-cell-survival-following-radiation-injury
#1
Yaojie Liang, Hongwei Zhou, Yibing Yao, Ailing Deng, Zhihong Wang, Boning Gao, Minhang Zhou, Yu Cui, Lili Wang, Lei Zhou, Bianhong Wang, Li Wang, Anqi Liu, Lanlan Qiu, Kun Qian, Yejian Lu, Wanping Deng, Xi Zheng, Zhengtao Han, Yonghui Li, Junzhong Sun
Radiation enteropathy is a common complication in cancer patients following radiation therapy. Thus, there is a need for agents that can protect the intestinal epithelium against radiation. 12-O-Tetradecanoylphorbol-13-acetate (TPA) has been shown to induce differentiation and/or apoptosis in multiple cell lines and primary cells. In the current report, we studied the function of TPA in radiation induced enteropathy in cultured rat intestinal epithelial cell line IEC-6 after ionizing radiation (IR) and in mice after high dose total-body gamma-IR (TBI)...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28538090/late-effects-in-pediatric-high-risk-neuroblastoma-survivors-after-intensive-induction-chemotherapy-followed-by-myeloablative-consolidation-chemotherapy-and-triple-autologous-stem-cell-transplants
#2
Amy E Armstrong, Karina Danner-Koptik, Shannon Golden, Jennifer Schneiderman, Morris Kletzel, Jennifer Reichek, Yasmin Gosiengfiao
Multimodal treatment in high-risk neuroblastoma has modestly improved survival; limited data exist on the late effects from these regimens. We report the sequelae of treatment incorporating 3 consecutive cycles of high-dose therapy and autologous stem cell transplants (ASCTs) without the use of total body irradiation (TBI). We reviewed the medical records of 61 patients treated on or following the Chicago Pilot 2 protocol between 1991 and 2008. Of the 25 patients who are alive (41%), 19 had near complete data to report...
May 23, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28532617/first-french-experiences-of-total-body-irradiations-using-helical-tomotherapy-%C3%A2
#3
R Sun, X Cuenca, R Itti, S Nguyen Quoc, J-P Vernant, J-J Mazeron, C Jenny, M Chea
PURPOSE: Dynamic conformal radiotherapy with helical TomoTherapy(®) (HT) offers a more quantitative paradigm for total body irradiation. Treatment planning, delivery, dose verification of the first French experiences of total body irradiation using helical TomoTherapy(®) are presented. MATERIALS AND METHODS: Patients planned for total body irradiation at our institution from February 2012 to May 2013 were reported. Total body irradiation consisted in a single fraction of 2Gy...
May 19, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28520453/-indeterminate-cell-histiocytosis-disappearance-of-skin-infiltration-following-electron-beam-therapy-and-an-application-of-2-chlorodeoxyadenosine-case-report
#4
Zdeněk Adam, Marta Ježová, Pavel Šlampa, Leoš Křen, Vladimír Vašků, Renata Koukalová, Zdeněk Řehák, Luděk Pour, Marta Krejčí, Zdeněk Král, Jiří Mayer
Indeterminate cell histiocytosis is a rare disease belonging to the group of malignant histiocytic diseases. The disease predominantly affects the skin. The disease appeared in the described patient at the age of 80 years. Morphs began to develop on the skin and rapidly spread over the whole body including the face. Only the hands and feet were left uncovered. The patients skin samples were taken from 2 sites for histological examination. The resulting conclusion was indeterminate cell histiocytosis. The treatment we chose was analogous to the procedures for Langerhans cell histiocytosis...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28515359/t-cell-progenitor-therapy-facilitated-thymopoiesis-depends-upon-thymic-input-and-continued-thymic-microenvironment-interaction
#5
Michelle J Smith, Dawn K Reichenbach, Sarah L Parker, Megan J Riddle, Jason Mitchell, Kevin C Osum, Mahmood Mohtashami, Heather E Stefanski, Brian T Fife, Avinash Bhandoola, Kristin A Hogquist, Georg A Holländer, Juan Carlos Zúñiga-Pflücker, Jakub Tolar, Bruce R Blazar
Infusion of in vitro-derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell-deficient (Rag1-/-) marrow with WT in vitro-generated proTs, limiting mature T cell development to infused proTs. ProTs within the host thymus led to a significant increase in thymic epithelial cells (TECs) by day 21 after transplant, increasing actively cycling TECs...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28511709/incorporation-of-high-dose-131-i-metaiodobenzylguanidine-treatment-into-tandem-high-dose-chemotherapy-and-autologous-stem-cell-transplantation-for-high-risk-neuroblastoma-results-of-the-smc-nb-2009-study
#6
Ji Won Lee, Sanghoon Lee, Hee Won Cho, Youngeun Ma, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Eun Joo Cho, Suk-Koo Lee, Do Hoon Lim
BACKGROUND: In our previous SMC NB-2004 study of patients with high-risk neuroblastomas, which incorporated total-body irradiation (TBI) with second high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT), the survival rate was encouraging; however, short- and long-term toxicities were significant. In the present SMC NB-2009 study, only TBI was replaced with (131)I-meta-iodobenzylguanidine (MIBG) treatment in order to reduce toxicities. METHODS: From January 2009 to December 2013, 54 consecutive patients were assigned to receive tandem HDCT/auto-SCT after nine cycles of induction chemotherapy...
May 16, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28508830/dosimetric-verification-of-dose-calculation-algorithm-in-the-lung-during-total-marrow-irradiation-using-helical-tomotherapy
#7
Ewelina Konstanty, Julian Malicki, Katarzyna Łagodowska, Anna Kowalik
INTRODUCTION: Treatment of proliferative diseases of the hematopoietic system involves, in most cases, chemotherapy combined with radiation therapy, which is intended to provide adequate immunosuppressant. Conventionally, total body irradiation (TBI) was used; however, total marrow irradiation (TMI) performed with helical tomotherapy (HT) has been proposed as an alternative, with the aim of delivering the highest dose in the target area (skeleton bone). PURPOSE: The purpose of this study is to evaluate the accuracy of the dose calculation algorithm for the lung in TMI delivered with HT...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28506845/ex-vivo-mesenchymal-precursor-cell-expanded-cord-blood-transplantation-following-reduced-intensity-conditioning-regimens-improves-time-to-neutrophil-recovery
#8
Rohtesh S Mehta, Rima M Saliba, Kai Cao, Indreshpal Kaur, Katy Rezvani, Julianne Chen, Amanda Olson, Simrit Parmar, Nina Shah, David Marin, Amin Alousi, Chitra Hosing, Uday Popat, Partow Kebriaei, Richard Champlin, Marcos de Lima, Donna Skerrett, Elizabeth Burke, Elizabeth J Shpall, Betul Oran
We previously showed the safety of using cord blood (CB) expanded ex vivo in cocultures with allogeneic mesenchymal precursor cells (MPC) after myeloablative conditioning with faster recovery of neutrophils and platelets compared with historical controls. Herein, we report the transplant outcomes of 27 patients with hematologic cancers who received one CB unit ex vivo expanded with MPCs in addition to an unmanipulated CB (MPC group) after reduced intensity conditioning (RIC). The results in this group were compared with 51 historical controls who received two unmanipulated CB units (control group)...
May 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28495643/humoral-immune-reconstitution-kinetics-following-allogeneic-hematopoietic-stem-cell-transplantation-in-children-a-maturation-block-of-igm-memory-b-cells-may-lead-to-impaired-antibody-immune-reconstitution
#9
Hisham Abdel-Azim, Amro Elshoury, Kris M Mahadeo, Robertson Parkman, Neena Kapoor
Although T cell immune reconstitution following allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been well studied, long-term B cell immune reconstitution remains less characterized. We evaluated humoral immune reconstitution among 71-pediatric allo-HSCT recipients. While tetanus toxoid (TT) antibody levels were normal at 1-year post allo-HSCT, anti-polysaccharide carbohydrate (PRP) antibodies remained persistently low for up to 5-years. While naive B cell counts normalized by 6-months, IgM memory B cell deficiency persisted for up to 2-years (P=0...
May 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28490987/stereotactic-body-radiation-therapy-for-liver-metastasis-the-linac-based-greater-poland-cancer-centre-practice
#10
Magdalena Fundowicz, Marta Adamczyk, Anna Kołodziej-Dybaś
AIM: The main purpose of this work is to give a technical description and present the properties of the liver SBRT protocol implemented in the Greater Poland Cancer Centre (GPCC) in Poznan, Poland. BACKGROUND: Stereotactic body radiation therapy (SBRT) for liver metastasis is a non-invasive therapeutic option which enables irradiation of a small target in the body with a high dose. MATERIALS AND METHODS: This study presents details of our linac-based liver SBRT protocol...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490983/institutional-experience-in-the-treatment-of-colorectal-liver-metastases-with-stereotactic-body-radiation-therapy
#11
Alejandra Méndez Romero, Fatma Keskin-Cambay, Rob M van Os, Joost J Nuyttens, Ben J M Heijmen, Jan N M IJzermans, Cornelis Verhoef
AIM: To investigate whether the impact of dose escalation in our patient population represented an improvement in local control without increasing treatment related toxicity. MATERIALS AND METHODS: A cohort of consecutive patients with colorectal liver metastases treated with stereotactic body radiation therapy (SBRT) between December 2002 and December 2013 were eligible for this study. Inclusion criteria were a Karnofsky performance status ≥80% and, according to the multidisciplinary tumor board, ineligibility for surgery or radiofrequency ablation...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490978/radiobiology-of-stereotactic-body-radiation-therapy-sbrt
#12
REVIEW
Miquel Macià I Garau
Recent advances in the technology of radiotherapy have enabled the development of new therapeutic modalities that deliver radiation with very high accuracy, reduced margins and high dose conformation, allowing the reduction of healthy tissue irradiated and therefore minimizing the risk of toxicity. The next step was to increase the total tumor dose using conventional fractionation (which remains the best way to relatively radioprotect healthy tissues when large volumes are treated) or to use new fractionation schemes with greater biological effectiveness...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28489465/effects-of-phototherapy-plus-physical-training-on-metabolic-profile-and-quality-of-life-in-postmenopausal-women
#13
Fernanda Rossi Paolillo, Audrey Borghi-Silva, Ross Arena, Nivaldo Antonio Parizotto, Cristina Kurachi, Vanderlei Salvador Bagnato
A cluster of metabolic abnormalities are markedly higher among postmenopausal women. The present study evaluated the effects of infrared-light-emitting diode (LED) during treadmill training on multiple metabolic markers, body fat, dietary habits and quality of life in postmenopausal women. Forty five postmenopausal women aged 50 to 60 years were randomly assigned to one of three groups; thirty women successfully completed the full study. The three groups were: (i) the LED group, which performed treadmill training associated with phototherapy (n=10); (ii) the exercise group, which carried out treadmill training only (n=10) and; (iii) the sedentary group, which neither performed physical training nor underwent phototherapy (n=10)...
May 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28487142/risk-factors-for-recurrent-pneumonia-in-post-irradiated-patients-with-nasopharyngeal-carcinoma
#14
Jing-Jie Wang, Rong-San Jiang, Ting-Ting Yen, Kai-Li Liang
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a common cancer in eastern Asia. Chemoradiotherapy is the main treatment modality for NPC. Dysphagia and aspiration is not uncommon in post-irradiated NPC patients. The purpose of this study was to investigate the risk factors for recurrent pneumonia and the prognosis. METHODS: A retrospective chart review was conducted from January 2004 to December 2014. NPC patients who had been hospitalized for pneumonia in the study hospital were enrolled...
May 6, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28480860/-research-of-intestinal-microflora-in-the-rats-following-the-internal-and-external-irradiation
#15
Y Kairkhanova, N Chaizhunusоva, M Urazalin, V Stepanenko, M Hоshi
The aim of the research was comparative investigation of the quantitative and qualitative composition of large intestinal microflora following internal (by dispersed powdered 56Mn) and internal exposure of Wistar rats. Ten weeks-old male Wistar rats were used. Rats were divided into four groups: L-56Mn group with 12 rats, H-56Mn with ten rats, 60Co group with nine rats and control group with nine rats. L-56Mn and H-56Mn groups were exposed to two different doses of 56MnO2 powder. 60Co group received 2 Gy of external 60Co γ-ray whole body irradiation...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28467754/metabolomic-analysis-of-mice-exposed-to-gamma-radiation-reveals-a-systemic-understanding-of-total-body-exposure
#16
Srujana Golla, Jaya Prakash Golla, Kristopher W Krausz, Soumen K Manna, Cedric Simillion, Diren Beyoğlu, Jeffrey R Idle, Frank J Gonzalez
Diagnostic markers are needed for accidental or deliberate radiation exposure that could cause acute and chronic radiation toxicity. Biomarkers of temporal, dose-dependent, aging-attenuated and multiple radiation exposures have been previously described by others. However, the physiological origin and biochemical networks that generate these biomarkers and their association at the molecular level have yet to be explored. Hence, the discovery and identification of total-body-irradiation-induced tissue specific biomarkers remains an enormous challenge within radiation biodosimetry research...
May 2017: Radiation Research
https://www.readbyqxmd.com/read/28466154/spinal-cord-constraints-in-the-era-of-high-precision-radiotherapy-retrospective-analysis-of-62%C3%A2-spinal-paraspinal-lesions-with-possible-infringements-of-spinal-cord-constraints-within-a%C3%A2-minimal-volume
#17
Sebastian Zschaeck, Peter Wust, Reinhold Graf, Waldemar Wlodarczyk, Reinhard Schild, Alexander Henry Thieme, Mirko Weihrauch, Volker Budach, Pirus Ghadjar
OBJECTIVE: Current constraints aim to minimize the risk of radiation myelitis by the use of restrictive maximal spinal cord doses, commonly 50 Gy. However, several studies suggested that a dose-volume effect could exist. Based on these observations, we evaluated patients receiving potentially excessive doses to the spinal cord within minimal volumes. PATIENTS AND METHODS: Patients receiving radiotherapy between June 2010 and May 2015 using the Novalis(TM) (Varian, Palo Alto, CA, USA; Brainlab, Heimstetten, Germany) radiosurgery system were retrospectively analyzed...
May 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28463588/the-lactate-dehydrogenase-inhibitor-gossypol-inhibits-radiation-induced-pulmonary-fibrosis
#18
Jennifer L Judge, Shannon H Lacy, Wei-Yao Ku, Kristina M Owens, Eric Hernady, Thomas H Thatcher, Jacqueline P Williams, Richard P Phipps, Patricia J Sime, R Matthew Kottmann
Exposure of the lung to ionizing radiation that occurs in radiotherapy, as well as after accidental or intentional mass casualty incident can result in pulmonary fibrosis, which has few treatment options. Pulmonary fibrosis is characterized by an accumulation of extracellular matrix proteins that create scar tissue. Although the mechanisms leading to radiation-induced pulmonary fibrosis remain poorly understood, one frequent observation is the activation of the profibrotic cytokine transforming growth factor-beta (TGF-β)...
May 2, 2017: Radiation Research
https://www.readbyqxmd.com/read/28462895/irradiation-of-anatomically-defined-pelvic-subsites-and-acute-hematologic-toxicity-in-anal-cancer-patients-undergoing-chemoradiation
#19
Brent Rose, Devarati Mitra, Theodore S Hong, Kyung-Wook Jee, Andrzej Niemierko, Lorraine N Drapek, Lawrence S Blaszkowsky, Jill N Allen, Janet E Murphy, Jeffrey W Clark, David P Ryan, Jennifer Y Wo
PURPOSE: Chemoradiation for the treatment of anal cancer is known to cause significant hematologic toxicity (HT). We sought to investigate if radiation dose to specific pelvic subsites is associated with increased HT risk. METHODS AND MATERIALS: Forty-five patients with nonmetastatic anal cancer who received definitive chemoradiation with intensity modulated radiation therapy and concurrent mitomycin-C and 5-fluorouracil were studied. Total pelvic bone marrow (TBM) was divided into 3 subsites: lumbosacral bone marrow (LSBM), including the entire sacrum and L5 vertebral body; iliac bone marrow (IBM) extending from the iliac crests to the superior border of the femoral head; and lower pelvic bone marrow, including the pubic bones, ischia, acetabula, and proximal femurs...
March 23, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28458462/partial-lipodystrophy-in-patients-who-have-undergone-hematopoietic-stem-cell-transplantation-during-childhood-an-institutional-cross-sectional-survey
#20
Masanori Adachi, Yuji Oto, Koji Muroya, Junko Hanakawa, Yumi Asakura, Hiroaki Goto
Partial lipodystrophy (PD), a condition similar to metabolic syndrome without obesity, is one of the late complications of hematopoietic stem cell transplantation (HSCT) performed during childhood. We aimed to investigate the prevalence and risk factors of PD. A cross-sectional survey was performed in a children's hospital, targeting patients treated for a malignancy or hematological disorder, and who were disease-free for > 24 mo. PD was defined as gluteal lipoatrophy and lipohypertrophy of the cheeks or neck associated with diabetes and/or fatty liver disease...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
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