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https://www.readbyqxmd.com/read/28934562/the-enduring-legacy-of-250-years-of-pharmacology-in-edinburgh
#1
John S Kelly, Angus V P Mackay
Two hundred fifty years ago, the University of Edinburgh appointed Francis Home to the first chair of materia medica, the accumulated knowledge of materials used in healing. Francis Home and his colleagues were determined to improve the quality of medical training in Edinburgh by introducing a final examination and compiling a catalog of medicines validated by the Royal College of Physicians of Edinburgh. The catalog, known as the Edinburgh Pharmacopoeia, was a great success, partly due to the orderly nature of its contents, its routine editing to eliminate worthless entries, and the introduction of new treatments whose preparation was precisely documented...
September 13, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28930278/literature-review-of-research-on-chronic-pain-and-yoga-in-military-populations
#2
REVIEW
Shari Miller, Susan Gaylord, Alex Buben, Carrie Brintz, Kristine Rae Olmsted, Nakisa Asefnia, Michael Bartoszek
Background: Although yoga is increasingly being provided to active duty soldiers and veterans, studies with military populations are limited and effects on chronic pain are largely unknown. We reviewed the existing body of literature and provide recommendations for future research. Methods: We conducted a literature review of electronic databases (PubMed, PsychINFO, Web of Science, Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index-Science, and Conference Proceedings Citation Index-Social Science & Humanities)...
September 1, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28925963/on-the-role-of-processing-parameters-in-producing-recycled-aluminum-aa6061-based-metal-matrix-composite-mmc-alr-prepared-using-hot-press-forging-hpf-process
#3
Azlan Ahmad, Mohd Amri Lajis, Nur Kamilah Yusuf
Solid-state recycling, which involves the direct recycling of scrap metal into bulk material using severe plastic deformation, has emerged as a potential alternative to the conventional remelting and recycling techniques. Hot press forging has been identified as a sustainable direct recycling technique that has fewer steps and maintains excellent material performance. An experimental investigation was conducted to explore the hardness and density of a recycled aluminum-based metal matrix composite by varying operating temperature and holding time...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28925884/prevention-and-treatment-for-chemotherapy-induced-peripheral-neuropathy-therapies-based-on-cipn-mechanisms
#4
Lang-Yue Hu, Wen-Li Mi, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Ying
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible adverse effect of many antineoplastic agents, among which sensory abnormities are common and the most suffering issues. The pathogenesis of CIPN has not been completely understood, and strategies for CIPN prevention and treatment are still open problems for medicine. OBJECTIVES: The objective of this paper is to review the mechanism-based therapies against sensory abnormities in CIPN...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28922212/equity-of-physical-characteristics-between-adolescent-males-and-females-participating-in-single-or-mixed-gender-sport
#5
L M Krause, G A Naughton, A C Benson, S Tibbert
PURPOSE: Policies on single or mixed sex junior sports participation continue to be challenged publically and legally. Often challenges relate to perceptions of size and performance variability between adolescent males and females, yet the evidence base behind these challenges lacks recent review and rigor. METHODS: Physical performance was compared between males and females from two groups of younger (<13 years, n = 109, 67% females, 33% males) and older (>13 years, n = 108, 43% females, 57% males) adolescents...
September 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28917030/the-role-of-intra-session-exercise-sequence-in-the-interference-effect-a-systematic-review-with-meta-analysis
#6
REVIEW
Lee Eddens, Ken van Someren, Glyn Howatson
BACKGROUND: There is a necessity for numerous sports to develop strength and aerobic capacity simultaneously, placing a significant demand upon the practice of effective concurrent training methods. Concurrent training requires the athlete to perform both resistance and endurance exercise within a training plan. This training paradigm has been associated with an 'interference effect', with attenuated strength adaptation in comparison to that following isolated resistance training. The effectiveness of the training programme rests on the intricacies of manipulating acute training variables, such as exercise sequence...
September 15, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28912730/diagnosis-of-swimming-induced-pulmonary-edema-a-review
#7
REVIEW
Hannes Grünig, Pantelis T Nikolaidis, Richard E Moon, Beat Knechtle
Swimming induced pulmonary edema (SIPE) is a complication that can occur during exercise with the possibility of misdiagnosis and can quickly become life threatening; however, medical literature infrequently describes SIPE. Therefore, the aim of this review was to analyse all individual cases diagnosed with SIPE as reported in scientific sources, with an emphasis on the diagnostic pathways and the key facts resulting in its diagnosis. Due to a multifactorial and complicated pathophysiology, the diagnosis could be difficult...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28912674/a-mechanistic-understanding-of-axon-degeneration-in-chemotherapy-induced-peripheral-neuropathy
#8
REVIEW
Yusuke Fukuda, Yihang Li, Rosalind A Segal
Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several anti-neoplastic agents. CIPN typically presents with neuropathic pain, numbness of distal extremities, and/or oversensitivity to thermal or mechanical stimuli. This adverse side effect often requires a reduction in chemotherapy dosage or even discontinuation of treatment...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28911261/out-of-the-frying-pan-and-into-the-fire-damage-associated-molecular-patterns-and-cardiovascular-toxicity-following-cancer-therapy
#9
Nicole S Klee, Cameron G McCarthy, Patricia Martinez-Quinones, R Clinton Webb
Cardio-oncology is a new and rapidly expanding field that merges cancer and cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer therapy; in fact, it is the second leading cause of death in cancer survivors after recurrent cancer. It has been well documented that many cancer chemotherapeutic agents cause cardiovascular toxicity. Nonetheless, the underlying cause of cancer therapy-induced cardiovascular toxicity is largely unknown. In this review, we discuss the potential role of damage-associated molecular patterns (DAMPs) as an underlying contributor to cancer therapy-induced cardiovascular toxicity...
September 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28905677/ethical-tensions-a-qualitative-systematic-review-of-new-graduate-perceptions
#10
Tori Hazelwood, Carolyn M Murray, Amy Baker, Mandy Stanley
BACKGROUND: New graduate transition into the workforce is challenging and can involve managing ethical tensions. Ethical tensions cause new graduates to doubt their capabilities due to their lack of experience. To support new graduates, we need to know what these ethical tensions are. OBJECTIVES: To explore the ethical tensions perceived to occur in practice for new graduate health professionals. RESEARCH DESIGN: This qualitative systematic review involved a search of five databases (Medline, EMBASE, AMED, CINAHL and Scopus) which resulted in the retrieval of 3554 papers...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28905258/is-biomedical-research-protected-from-predatory-reviewers
#11
Aceil Al-Khatib, Jaime A Teixeira da Silva
Authors endure considerable hardship carrying out biomedical research, from generating ideas to completing their manuscripts and submitting their findings and data (as is increasingly required) to a journal. When researchers submit to journals, they entrust their findings and ideas to editors and peer reviewers who are expected to respect the confidentiality of peer review. Inherent trust in peer review is built on the ethical conduct of authors, editors and reviewers, and on the respect of this confidentiality...
September 13, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28904001/kv3-channels-enablers-of-rapid-firing-neurotransmitter-release-and-neuronal-endurance
#12
REVIEW
Leonard K Kaczmarek, Yalan Zhang
The intrinsic electrical characteristics of different types of neurons are shaped by the K(+) channels they express. From among the more than 70 different K(+) channel genes expressed in neurons, Kv3 family voltage-dependent K(+) channels are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. In general, the four Kv3 channels Kv3.1-Kv3.4 share the property of activating and deactivating rapidly at potentials more positive than other channels...
October 1, 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28899117/book-review-l-inqui%C3%A3-tude-permanente-enduring-concern-l-inqui%C3%A3-tude-permanente-enduring-concern-by-de-m-uzan-michel-paris-gallimard-2015-192-pp-%C3%A2-17-50
#13
Dominique Scarfone
No abstract text is available yet for this article.
April 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28887796/enabling-work-occupational-therapy-interventions-for-persons-with-occupational-injuries-and-diseases-a-scoping-review
#14
REVIEW
Alexa Jane T Blas, Kenneth Matthew B Beltran, Pauline Gail V Martinez, Daryl Patrick G Yao
Purpose This review aims to map the scope of published research on occupational therapy (OT) interventions and pertinent work and work-related outcomes for persons with occupational injuries and diseases. Methods The scoping review adapted Arksey and O'Malley's framework. Six electronic databases were searched. Ancestral search was also done on five systematic reviews. The search was conducted from September 2015 to October 2015. Interventions and outcomes were coded using the International Classification of Functioning, Disability and Health Core Set for Vocational Rehabilitation to plot trends...
September 8, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28885932/screening-for-complicated-grief-in-a-military-mental-health-clinic
#15
Eileen M Delaney, Kathryn J Holloway, Derek M Miletich, Jennifer A Webb-Murphy, Nicole M Lanouette
INTRODUCTION: Bereavement is one of the most common and stressful life experiences one can endure. Typical grief reactions follow a course of recovery in which individuals come to terms with the loss and resume functioning within weeks to months. However, for some, grief remains indefinitely distressing. Complicated Grief (CG) refers to significant chronic impairment that stems from bereavement. Military service members experience myriad factors that likely increase their risk for developing CG...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28882521/reliability-of-physical-functioning-tests-in-patients-with-low-back-pain-a-systematic-review
#16
REVIEW
Lenie Denteneer, Ulrike Van Daele, Steven Truijen, Willem De Hertogh, Jill Meirte, Gaetane Stassijns
OBJECTIVE: The aim of this study was to provide a comprehensive overview of physical functioning tests in patients with low back pain (LBP) and to investigate their reliability. DATA SOURCES: A systematic computerized search was finalized in four different databases on the 24th of June 2017: Pubmed, Web of Science, Embase and Medline. STUDY SELECTION: PRISMA guidelines were followed during all stages of this review. Clinical studies that investigate the reliability of physical functioning tests in patients with LBP were eligible...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28879571/risk-factors-for-non-contact-injury-in-adolescent-cricket-pace-bowlers-a-systematic-review
#17
REVIEW
Mitchell R L Forrest, Jeffrey J Hebert, Brendan R Scott, Stefano Brini, Alasdair R Dempsey
BACKGROUND: Adolescent cricket pace bowlers are prone to injury. Recognising the risk factors for non-contact injury in this population will aid future injury prevention strategies. OBJECTIVE: To identify the risk factors for non-contact injury in adolescent cricket pace bowlers. METHODS: We systematically searched PubMed, Cochrane Library, PEDro, SPORTDiscus, Embase, and the South African Journal of Sports Medicine to identify all experimental and observational studies reporting risk factors for non-contact injuries in pace bowlers (aged 12-19 years)...
September 6, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28878632/the-influence-of-regional-distribution-and-pharmacologic-specificity-of-gabaar-subtype-expression-on-anesthesia-and-emergence
#18
REVIEW
Iris Speigel, Edyta K Bichler, Paul S García
Anesthetics produce unconsciousness by modulating ion channels that control neuronal excitability. Research has shown that specific GABAA receptor (GABAAR) subtypes in particular regions of the central nervous system contribute to different hyperpolarizing conductances, and behaviorally to distinct components of the anesthetized state. The expression of these receptors on the neuron cell surface, and thus the strength of inhibitory neurotransmission, is dynamically regulated by intracellular trafficking mechanisms...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28878622/ganaxolone-a-new-treatment-for-neonatal-seizures
#19
REVIEW
Tamara Yawno, Suzie L Miller, Laura Bennet, Flora Wong, Jonathan J Hirst, Michael Fahey, David W Walker
Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce "de novo" injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of ganaxolone, a GABA(A) agonist neurosteroid, as a novel neonatal therapy. We discuss evidence that ganaxolone can provide both seizure control and neuroprotection with a high safety profile when administered early following birth-related hypoxia, and show evidence that it is likely to prevent or reduce the incidence of the enduring disabilities associated with preterm birth, cerebral palsy, and epilepsy...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28870627/endurance-exercise-improves-function-in-individuals-with-parkinson-s-disease-a-meta-analysis
#20
Alicia Flach, Lisa Jaegers, Mary Krieger, Emily Bixler, Patrick Kelly, Edward P Weiss, S Omar Ahmad
Current evidence has shown that exercise can reduce symptoms of Parkinson's disease (PD). However, previous studies indicated mixed results, possibly because of variability in terms of the nature of the exercise interventions. The purpose of this study was to perform a metaanalysis of current evidence from endurance exercise intervention studies for effects on the United Parkinson's Disease Rating Scale (UPDRS) in individuals with PD. A systematic literature search in six electronic databases was performed and two independent reviewers screened the title and abstract of 1106 records captured by the initial search...
September 1, 2017: Neuroscience Letters
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