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pediatric hypercalcemia

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https://www.readbyqxmd.com/read/27832822/sarcoidosis-presenting-as-granulomatous-myositis-in-a-16-year-old-adolescent
#1
Amir B Orandi, Eric Eutsler, Cole Ferguson, Andrew J White, Maleewan Kitcharoensakkul
BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle. These organized collections of immune cells have important pathophysiologic action including cytokine production leading to inflammation as well as enzymatic conversion of cholecalciferol to calcitriol via 1-α hydroxylase. There are limited reports of isolated granulomatous myositis causing hypercalcemia in pediatric patients...
November 10, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27798933/a-pediatric-patient-with-a-cyp24a1-mutation-four-years-of-clinical-biochemical-and-imaging-follow-up
#2
Diana-Alexandra Ertl, Adalbert Raimann, Dagmar Csaicsich, Janina M Patsch, Franco Laccone, Gabriele Haeusler
BACKGROUND: A female infant was admitted to hospital due to failure to thrive. She presented hypercalcemia (4.09 mmol/L, normal range: 2.2-2.65 mmol/L), high 25-hydroxyvitamin D (283 nmol/L, normal range: 75-250 nmol/L), 1,25-dihydroxyvitamin D in the upper normal range, and low parathyroid hormone. Vitamin D intoxication was suspected. The patient had received routine rickets prophylaxis. METHODS: Williams-Beuren syndrome was genetically excluded. Sequencing of CYP24A1 showed 2 mutations: c...
November 1, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27744630/metabolic-risk-factors-in-pediatric-stone-formers-a-report-from-an-emerging-economy
#3
Kiran Imran, Mirza Naqi Zafar, Uzma Ozair, Sadia Khan, Syed Adibul Hasan Rizvi
The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demographics, blood and 24 h urine for calcium, magnesium, phosphate, uric acid, electrolytes and additional protein, citrate, ammonia and oxalate in urine. All reported values were two sided and statistical significance was considered at p value ≤0...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27683282/comparison-of-300-000-and-600-000%C3%A2-iu-oral-vitamin-d-bolus-for-vitamin-d-deficiency-in-young-children
#4
Jiyalal Harnot, Sanjay Verma, Sunit Singhi, Naveen Sankhyan, Naresh Sachdeva, Bhavneet Bharti
OBJECTIVE: To compare the efficacy and safety of 300,000 and 600,000 IU vitamin-D single-oral dose for the treatment of vitamin-D deficiency (VDD) in young children (3 mo - 3 y). METHODS: This double-blind randomized control trial (Clinical Trail Registration-CTRI/2012/05/002621) was conducted in the Pediatric out-patient department (OPD) at a tertiary-care referral hospital. Children (3 mo - 3 y) with clinical/radiological features suggestive of VDD were screened; those found to be having 25(OH)D below 15 ng/ml and meeting inclusion and exclusion criteria's were enrolled after taking informed consent...
September 29, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27574996/hypercalcemia-in-patients-with-williams-beuren-syndrome
#5
Sampat Sindhar, Michael Lugo, Mark D Levin, Joshua R Danback, Benjamin D Brink, Eric Yu, Dennis J Dietzen, Amy L Clark, Carolyn A Purgert, Jessica L Waxler, Robert W Elder, Barbara R Pober, Beth A Kozel
OBJECTIVE: To evaluate the timing, trajectory, and implications of hypercalcemia in Williams-Beuren syndrome (WBS) through a multicenter retrospective study. STUDY DESIGN: Data on plasma calcium levels from 232 subjects with WBS aged 0-67.1 years were compared with that in controls and also with available normative data. Association testing was used to identify relevant comorbidities. RESULTS: On average, individuals with WBS had higher plasma calcium levels than controls, but 86...
November 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27394135/mutational-spectrum-of-cyp24a1-gene-in-a-cohort-of-italian-patients-with-idiopathic-infantile-hypercalcemia
#6
Maddalena Gigante, Luisa Santangelo, Sterpeta Diella, Gianluca Caridi, Lucia Argentiero, Maria Michela D''Alessandro, Marida Martino, Emma Diletta Stea, Gianluigi Ardissino, Vincenza Carbone, Silvana Pepe, Domenico Scrutinio, Silvio Maringhini, Gian Marco Ghiggeri, Giuseppe Grandaliano, Mario Giordano, Loreto Gesualdo
BACKGROUND/AIMS: Loss-of-function mutations in the CYP24A1 gene, which encodes the vitamin D-24 hydroxylase, have been recognized as a cause of elevated 1,25-dihydroxyvitamin D concentrations, hypercalcemia, hypercalciuria, nephrocalcinosis and nephrolithiasis in infants and adults. As only a case report describing 2 adult patients has been reported in Italian population, we report here the mutation analysis of CYP24A1 gene in an Italian cohort of 12 pediatric and adult patients with idiopathic infantile hypercalcemia (IIH)...
2016: Nephron
https://www.readbyqxmd.com/read/27339816/p210-bcr-abl1-positive-pediatric-b-lineage-acute-lymphoblastic-leukemia-presenting-with-hypercalcemia
#7
Karthik Bommannan, Sidharth Totadri, Man Updesh Singh Sachdeva, Shano Naseem, Amita Trehan, Neelam Varma
No abstract text is available yet for this article.
June 24, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26761480/severe-hypercalcemia-as-a-form-of-acute-lymphoblastic-leukemia-presentation-in-children
#8
Andreia Luís Martins, Marta Moniz, Pedro Sampaio Nunes, Clara Abadesso, Helena Cristina Loureiro, Ximo Duarte, Helena Isabel Almeida
Hypercalcemia is a rare metabolic disorder in children and is potentially fatal. It has a wide differential diagnosis, including cancer. Here, we report the case of a previously healthy 3-year-old who was admitted to the emergency room with fatigue, hyporeactivity, fever and limping gait that had evolved over 5 days and that was progressively worsening. On examination the patient was unconscious (Glasgow coma score: 8). Laboratory tests indicated severe hypercalcemia (total calcium 21.39mg/dL, ionized calcium 2...
October 2015: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/26650250/parathyroid-cancer-in-the-pediatric-patient
#9
REVIEW
Jesse T Davidson, Catherine G Lam, Rose B McGee, Armita Bahrami, Alicia Diaz-Thomas
CONTEXT: Parathyroid carcinoma is exceedingly rare in children. We describe a case of parathyroid cancer in a young female who was originally classified as benign and managed surgically. Upon her diagnosis with malignancy, concurrent with metastatic lung involvement, she was referred for medical and surgical palliation to control her symptomatic hypercalcemia. We briefly review published childhood cases, consider the challenges in differentiating malignant from benign hyperparathyroidism in this age group, and discuss the association of CDC73 mutations with parathyroid carcinoma...
January 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26594832/toxic-metabolic-risk-factors-in-pediatric-pancreatitis-recommendations-for-diagnosis-management-and-future-research
#10
Sohail Z Husain, Veronique Morinville, John Pohl, Maisam Abu-El-Haija, Melena D Bellin, Steve Freedman, Peter Hegyi, Melvin B Heyman, Ryan Himes, Chee Y Ooi, Sarah J Schwarzenberg, Danielle Usatin, Aliye Uc
Pancreatitis in children can result from metabolic and toxic risk factors, but the evidence linking these factors is sparse. We review the evidence for association or causality of these risk factors in pancreatitis, discuss management strategies, and their rationale. We conducted a review of the pediatric pancreatitis literature with respect to the following risk factors: hyperlipidemia, hypercalcemia, chronic renal failure, smoking exposure, alcohol, and medications. Areas of additional research were identified...
April 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26540764/nephrolithiasis-and-nephrocalcinosis-in-children-metabolic-and-genetic-factors
#11
REVIEW
Velibor Tasic, Zoran Gucev
Diagnosis and management of pediatric nephrolithiasis/nephrocalcinosis is a very complex and challenging task for every pediatrician. It is based on correct. disease history taking, which may guide to the mode of inheritance (dominant, recessive, x-linked). Ethnicity and consanguinity should also be investigated since they predispose to high prevalence of certain disorders. One should always begin with cheap and available screening tests. Herein we will review clinical, biochemical, metabolic and genetic characteristics of the inherited diseases which lead to nephrolithiasis/nephrocalcinosis, such as: idiopathic hypercalciuria, renal hypophosphatemia, renal tubular acidosis, idiopathic infantile hypercalcemia, Dent disease, familial hypomagnesemia with hypercalciuria and nephrocalcinosis, hypocitraturia, cystinuria, primary hyperoxaluria and renal hypouricemia...
September 2015: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/26430336/calcium-homeostasis-disorder-during-and-after-neonatal-extracorporeal-membrane-oxygenation
#12
Jerome Rambaud, Isabelle Guellec, Julia Guilbert, Pierre-Louis Léger, Sylvain Renolleau
BACKGROUND AND AIMS: Extracorporeal membrane oxygenation (ECMO) is used during pediatric resuscitation in case of refractory hypoxemia or septic shock under maximum therapy. Previous studies describe calcium homeostasis dysregulation. The aim of this study was to confirmed of calcium homeostasis dysregulation in neonates under ECMO and supposed news explanation. SUBJECTS AND METHODS: From November 2012 to July 2013, we performed a prospective single center observational study...
September 2015: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26213611/case-report-pulmonary-alveolar-calcification-as-a-result-of-severe-hypercalcemia-due-to-acute-lymphoblatic-leukemia
#13
Jose Colleti Junior, Eliana Carla Armelin Benites, Gustavo Spadaccia Dos Santos Fernandes, Norberto Antonio Freddi, Walter Koga, Werther Brunow de Carvalho
Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL)...
2015: F1000Research
https://www.readbyqxmd.com/read/26196201/pilot-study-evaluating-efficacy-of-2-regimens-for-hypovitaminosis-d-repletion-in-pediatric-inflammatory-bowel-disease
#14
RANDOMIZED CONTROLLED TRIAL
Robert Z Simek, Jarod Prince, Sana Syed, Cary G Sauer, Bernadette Martineau, Tanya Hofmekler, Alvin J Freeman, Archana Kumar, Barbara O McElhanon, Bess T Schoen, Gayathri Tenjarla, Courtney McCracken, Thomas R Ziegler, Vin Tangpricha, Subra Kugathasan
OBJECTIVES: Vitamin D is critical for skeletal health; hypovitaminosis D is common in pediatric inflammatory bowel disease (IBD), yet optimal repletion therapy is not well studied. We aimed to conduct a pilot trial comparing the efficacy of 2 vitamin D regimens of weekly dosing for the repletion of hypovitaminosis D in pediatric IBD. METHODS: Subjects identified from our IBD clinic with 25-hydroxyvitamin D (25[OH]D) concentrations <30 ng/mL were randomized to 10,000 (n = 18) or 5000 (n = 14) IU of oral vitamin D3/10 kg body weight per week for 6 weeks...
February 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25831028/primary-hyperparathyroidism-an-uncommon-cause-of-hip-pain
#15
Muhammad Waseem, Evelyn Erickson, Samuel Agyare, Mushtaq A Godil
Hip pain is a common complaint in a pediatric emergency department. The causes of hip pain are diverse and generally include traumatic and infectious causes. We report a case of hip pain caused by deep soft tissue infection associated with hypercalcemia and primary hyperparathyroidism. Atypical presentation of primary hyperparathyroidism may result in a delay in diagnosis.
April 2015: Pediatric Emergency Care
https://www.readbyqxmd.com/read/25710805/mineral-metabolism-in-european-children-living-with-a-renal-transplant-a-european-society-for-paediatric-nephrology-european-renal-association-european-dialysis-and-transplant-association-registry-study
#16
Marjolein Bonthuis, Marco Busutti, Karlijn J van Stralen, Kitty J Jager, Sergey Baiko, Sevcan Bakkaloğlu, Nina Battelino, Maria Gaydarova, Bruno Gianoglio, Paloma Parvex, Clara Gomes, James G Heaf, Ludmila Podracka, Dafina Kuzmanovska, Maria S Molchanova, Tatiana E Pankratenko, Fotios Papachristou, György Reusz, Maria José Sanahuja, Rukshana Shroff, Jaap W Groothoff, Franz Schaefer, Enrico Verrina
BACKGROUND AND OBJECTIVES: Data on mineral metabolism in pediatric renal transplant recipients largely arise from small single-center studies. In adult patients, abnormal mineral levels are related to a higher risk of graft failure. This study used data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry to study the prevalence and potential determinants of mineral abnormalities, as well as the predictive value of a disturbed mineral level on graft survival in a large cohort of European pediatric renal transplant recipients...
May 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/25556556/critical-hypercalcemia-following-discontinuation-of-denosumab-therapy-for-metastatic-giant-cell-tumor-of-bone
#17
Nathan Gossai, Megan V Hilgers, Lynda E Polgreen, Emily G Greengard
We report a 14 year-old female with Giant Cell Tumor of Bone, successfully treated with denosumab, who developed critical hypercalcemia after completion of therapy. Five months after her last denosumab treatment, serum calcium rose to 16.5 mg/dL (normal 8.7-10.8 mg/dL), nearly double her prior level of 8.4 mg/dL while receiving denosumab. She required emergent intervention to treat her hypercalcemia, which was attributed to rebound osteoclast activity and osteopetrotic bone. Denosumab is widely used in adults and increasingly in pediatric oncology populations and our experience demonstrates the need for close monitoring for electrolyte derangements following discontinuation...
June 2015: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/25511115/rapid-normalization-of-vitamin-d-levels-a-meta-analysis
#18
J Dayre McNally, Klevis Iliriani, Supichaya Pojsupap, Margaret Sampson, Katie O'Hearn, Lauralyn McIntyre, Dean Fergusson, Kusum Menon
BACKGROUND: Vitamin D deficiency may represent a modifiable risk factor to improve outcome in severe illness. The efficacy of high-dose regimens in rapid normalization of vitamin D levels is uncertain. METHODS: We conducted a systematic review of pediatric clinical trials administering high-dose vitamin D to evaluate 25-hydroxyvitamin D (25[OH]D) response and characteristics associated with final 25(OH)D levels by using Medline, Embase, and the Cochrane Central Register of Controlled Trials, including reference lists of systematic reviews and eligible publications...
January 2015: Pediatrics
https://www.readbyqxmd.com/read/25376487/the-use-of-bisphosphonates-in-pediatrics
#19
REVIEW
Giampiero I Baroncelli, Silvano Bertelloni
Bisphosphonates are widely used for the prevention and treatment of osteoporosis in adulthood. In the last years, bisphosphonates have been increasingly used in pediatric patients for the treatment of a growing number of disorders associated with osteoporosis, resistant hypercalcemia or heterotopic calcifications. The use of bisphosphonates in pediatric patients has been proven safe; however, the risk of potential severe consequences into adulthood should be kept in mind. Well-defined criteria for bisphosphonates treatment in pediatric patients are not specified, therefore an accurate selection of patients who could benefit from bisphosphonates is mandatory...
2014: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/25188737/hypervitaminosis-a-causing-hypercalcemia-in-cystic-fibrosis-case-report-and-focused-review
#20
REVIEW
Khalid H Safi, Amy G Filbrun, Samya Z Nasr
Hypercalcemia is a rare complication of hypervitaminosis A. We report a pediatric patient with cystic fibrosis (CF) and pancreatic insufficiency who was found to have hypervitaminosis A causing hypercalcemia, complicated by nephrocalcinosis and renal impairment. The patient is a 4-year-old girl with pancreatic-insufficient CF, gastroesophageal reflux, oral aversion, and failure to thrive requiring gastrostomy tube placement. She was prescribed Source CF vitamins, but rarely received the full dose, due to emesis and intolerance...
October 2014: Annals of the American Thoracic Society
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