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pediatric hyperkalemia

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https://www.readbyqxmd.com/read/27826711/safety-of-enalapril-in-infants-admitted-to-the-neonatal-intensive-care-unit
#1
Lawrence C Ku, Kanecia Zimmerman, Daniel K Benjamin, Reese H Clark, Christoph P Hornik, P Brian Smith
Enalapril is used to treat hypertension and congestive heart failure in infants. However, enalapril is not labeled for neonates, and safety data in infants are sparse. To evaluate the safety of enalapril in young infants, we conducted a retrospective cohort study of infants who were exposed to enalapril in the first 120 days of life and were cared for in 348 neonatal intensive care units from 1997 to 2012. We determined the proportion of exposed infants who developed adverse events, including death, hypotension requiring pressors, hyperkalemia, and elevated serum creatinine...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27704256/achieving-remission-of-proteinuria-in-childhood-ckd
#2
Piero Ruggenenti, Paolo Cravedi, Antonietta Chianca, MariaRosa Caruso, Giuseppe Remuzzi
BACKGROUND: A multidrug treatment strategy that targets urinary proteins with an angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) up-titrated to the respective maximum tolerated dose combined with intensified blood pressure (BP) control has been found to prevent renal function loss in adults with proteinuric nephropathies. Herein, we investigated the effects of this treatment protocol in the pediatric patient population. METHODS: From May 2002 to September 2014 we included in this observational, longitudinal, cohort study 20 consecutive children with chronic nephropathies and 24-h proteinuria of >200 mg who had received ramipril and losartan up-titrated to the respective maximum approved and tolerated doses [mean (standard deviation) dose:2...
October 4, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27639857/hyperkalemia-in-young-children-blood-pressure-checked
#3
Richard Hollander, Geert Mortier, Koen van Hoeck
: Hyperkalemia in young children is a rare phenomenon and in many cases caused by hemolysis in the specimen due to difficulties in obtaining a sample. However, hyperkalemia can also be a sign of a rare Mendelian syndrome known as familial hyperkalemic hypertension or pseudohypoaldosteronism type II. This disease is characterized by hyperkalemia, hypertension, and mild hyperchloremic metabolic acidosis (with normal anion gap) despite normal glomerular filtration. Full recovery of these abnormalities with thiazide diuretics is essential not to miss the diagnosis of this syndrome...
September 17, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27362851/decreasing-iv-potassium-in-pediatric-cardiac-intensive-care-quality-improvement-project
#4
Leslie A Rhodes, Kevin M Wall, Staci L Abernathy, Ashley B Moellinger, Santiago Borasino, Jeffrey A Alten
OBJECTIVES: IV potassium supplementation is commonly used in the pediatric cardiovascular ICU. However, concentrated IV potassium chloride doses can lead to life-threatening complications. We report results of a quality improvement project aimed at decreasing concentrated IV potassium chloride exposure. DESIGN: Retrospective evaluation of a quality improvement project aimed at reducing IV potassium chloride exposure. SETTING: Pediatric cardiac ICU...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27215929/treatment-of-pediatric-hyperkalemia-with-sodium-polystyrene-sulfonate
#5
Ji Lee, Brady S Moffett
OBJECTIVE: To describe the safety and efficacy of sodium polystyrene sulfonate (SPS) in pediatric patients with acute hyperkalemia. METHODS: A retrospective chart review of all patients less than 18 years of age administered SPS for acute hyperkalemia at Texas Children's Hospital between 2011 and 2014. RESULTS: Our cohort consisted of 156 patients (mean age 6.8 ± 6.1 years). The peak mean potassium concentration observed was 6.5 ± 0...
November 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27111691/anesthetic-management-of-877-pediatric-patients-undergoing-muscle-biopsy-for-neuromuscular-disorders-a-20-year-review
#6
Frederic Shapiro, Umeshkumar Athiraman, David J Clendenin, Monica Hoagland, Navil F Sethna
BACKGROUND: The objectives are to review the anesthetic management and anesthetic-related adverse events in patients undergoing muscle biopsy for a broad spectrum of neuromuscular disorders (NMD). AIM: The study aims to assess the hypothesis that perceived awareness of potential anesthesia-induced hyperkalemia and MH in patients with NMD reduces the frequency of such events. METHODS: A 20-year retrospective review of 877 consecutive patients undergoing muscle biopsy to establish diagnoses of NMD has been performed...
July 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26936515/novel-mutations-in-the-cyp11b2-gene-causing-aldosterone-synthase-deficiency
#7
Niu Li, Juan Li, Yu Ding, Tingting Yu, Yongnian Shen, Qihua Fu, Yiping Shen, Xiaodong Huang, Jian Wang
Aldosterone synthase deficiency (ASD) is a rare, autosomal recessive inherited disease. Mutations in the CYP11B2 gene are responsible for the occurrence of ASD, and the clinical manifestations of ASD vary with age. Affected infants may develop symptoms of mineralocorticoid deficiency, including clinical presentation with frequent vomiting, a variable degree of hyponatremia, hyperkalemia, and metabolic acidosis combined with poor growth, which are easily confused with several other endocrine genopathies, including pseudohypoaldosteronism type 1 and congenital adrenal hyperplasia...
April 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26586073/acute-kidney-injury-in-a-child-a-case-of-munchausen-syndrome-by-proxy
#8
Mukta Mantan, Dhulika Dhingra, Aditi Gupta, Gulshan Rai Sethi
Renal and urologic problems in pediatric condition falsification (PCF) or Munchausen by proxy (MSP) can result in serious diagnostic dilemma. Symptoms of hematuria, pyuria and recurrent urinary tract infections have occasionally been described. However, MSP presenting as azotemia has not been previously reported. We describe the case of an unfortunate boy who had to undergo unnecessary hemodialysis for persistent hyperkalemia and azotemia before a final diagnosis of the falsification of investigations by the parents was made...
November 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26181299/comparatively-evaluating-medication-preparation-sequences-for-treatment-of-hyperkalemia-in-pediatric-cardiac-arrest-a-prospective-randomized-simulation-based-study
#9
RANDOMIZED CONTROLLED TRIAL
Amy M Arnholt, Jordan M Duval-Arnould, LeAnn M McNamara, Michael A Rosen, Karambir Singh, Elizabeth A Hunt
OBJECTIVES: To determine whether time to prepare IV medications for hyperkalemia varied by 1) drug, 2) patient weight, 3) calcium salt, and 4) whether these data support the Advanced Cardiac Life Support recommended sequence. DESIGN: Prospective randomized simulation-based study. SETTING: Single pediatric tertiary medical referral center. SUBJECTS: Pediatric nurses and adult or pediatric pharmacists. INTERVENTIONS: Subjects were randomized to prepare medication doses for one of four medication sequences and stratified by one of three weight categories representative of a neonate/infant, child, or adult-sized adolescent: 4, 20, and 50 kg...
September 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25968047/safety-of-octreotide-in-hospitalized-infants
#10
Daniela Testoni, Christoph P Hornik, Megan L Neely, Qinghong Yang, Ann W McMahon, Reese H Clark, P Brian Smith
BACKGROUND: Octreotide is used off-label in infants for treatment of chylothorax, congenital hyperinsulinism, and gastrointestinal bleeding. The safety profile of octreotide in hospitalized infants has not been described; we sought to fill this information gap. METHODS: We identified all infants exposed to at least 1 dose of octreotide from a cohort of 887,855 infants discharged from 333 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012...
July 2015: Early Human Development
https://www.readbyqxmd.com/read/25806675/use-and-safety-of-erythromycin-and-metoclopramide-in-hospitalized-infants
#11
Jessica E Ericson, Christopher Arnold, Jomani Cheeseman, Jordan Cho, Sarah Kaneko, Ele'na Wilson, Reese H Clark, Daniel K Benjamin, Vivian Chu, P Brian Smith, Christoph P Hornik
OBJECTIVE: Prokinetic medications are used in premature infants to promote motility and decrease time to full enteral feeding. Erythromycin and metoclopramide are the most commonly used prokinetic medications in the neonatal intensive care unit (NICU), but their safety profile is not well defined. METHODS: We conducted a large retrospective cohort study using data from 348 NICUs managed by the Pediatrix Medical Group. All of the infants exposed to ≥1 dose of erythromycin, metoclopramide, or both, from a cohort of 8,87,910 infants discharged between 1997 and 2012 were included...
September 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25734786/a-survey-demonstrating-lack-of-consensus-on-the-sequence-of-medications-for-treatment-of-hyperkalemia-among-pediatric-critical-care-providers
#12
Nnenna O Chime, Xun Luo, LeAnn McNamara, Akira Nishisaki, Elizabeth A Hunt
OBJECTIVE: Hyperkalemia is one of the reversible causes of cardiac arrest in children. The Advanced Cardiovascular Life Support guidelines have specific recommendations on the choice and sequence of medications for treatment of life-threatening hyperkalemia. However, the Pediatric Advanced Life Support guidelines have no specific treatment recommendations. The objective of this study was to measure the extent to which opinions diverge among pediatricians on the choice and sequence of medication administration in the management of hyperkalemia during cardiac arrest...
June 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25727836/-malignant-hyperthermia-syndrome-case-report
#13
Pedro Taffarel, Fernando Koffman, Andrea Zifferman, Sebastián Degiuseppe, Alejandro Mansilla, Marcelo Darduin, Marcelo Acerenza
Malignant hyperthermia syndrome is a family myopathy of pharmacogenetic nature, which appears as a skeletal muscle hypercatabolic syndrome linked to anesthesia. The incidence in pediatrics is 1 event per 10 000 surgeries. The clinical picture may have a rapid onset associated with succinylcholine, or a late onset related to inhalation agents. The clinical picture includes tachycardia, hyperthermia, hypercapnia, acidosis, muscle rigidity, hyperkalemia, renal failure and arrhythmia. Mortality without specific treatment is of 80% and drops to 7% with the use of dantrolene sodium...
April 2015: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/25660135/acute-peritoneal-dialysis-in-african-pediatric-area-experience-of-pediatric-nephrology-unit-of-yopougon-university-hospital-abidjan-c%C3%A3-te-d-ivoire
#14
Gnenefoly Diarrassouba, Laurence Adonis-Koffy, Ekou Niamien, Jean Baptiste Yaokreh, Pessa Albert Coulibaly
INTRODUCTION: Acute kidney injury (AKI) is a diagnostic emergency threatening patients in a major way. Pediatric renal extra purification methods are limited in African countries due to the nonavailability of resources. Peritoneal dialysis (PD) seems to be the modality that is the most practiced for children with acute renal failure (ARF). METHODOLOGY: We conducted a retrospective study on 5 years of records of children from 1 month to 15 years who have suffered an ARF and benefited from PD while being treated at the pediatric nephrology unit of the Chu of Yopougon...
2015: Blood Purification
https://www.readbyqxmd.com/read/25613362/sodium-bicarbonate-use-during-in-hospital-pediatric-pulseless-cardiac-arrest-a-report-from-the-american-heart-association-get-with-the-guidelines-%C3%A2-resuscitation
#15
Tia T Raymond, Daniel Stromberg, William Stigall, Grant Burton, Arno Zaritsky
BACKGROUND: Despite limited recommendations for using sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR), we hypothesized that SB continues to be used frequently during pediatric in-hospital cardiac arrest (IHCA) and that its use varies by hospital-specific, patient-specific, and event-specific characteristics. METHODS: We analyzed 3719 pediatric (<18 years) index pulseless CPR events from the American Heart Association Get With The Guidelines-Resuscitation database from 1/2000 to 9/2010...
April 2015: Resuscitation
https://www.readbyqxmd.com/read/25547874/pediatric-anterior-visual-pathway-gliomas-trends-in-fluid-and-electrolyte-dynamics-and-their-management-nuances
#16
Devesh K Singh, Sanjay Behari, Awadhesh K Jaiswal, Rabi N Sahu, Arun K Srivastava, Anant Mehrotra, Preeti Dabadgaon
PURPOSE: Trends in pre- and postoperative fluid, electrolyte and osmolarity changes, and incidence of diabetes insipidus (DI) were assessed in pediatric patients with anterior visual pathway gliomas (AVPGs). METHODS: Thirty-three patients with AVPGs (age < 16 years) were divided into two groups: (1) no hypothalamic involvement [NHI; n = 17 (51.5 %) including optic (5, 15.2 %); chiasmal (5, 15.2 %); and optico-chiasmal (7, 21.2 %)] and (2) hypothalamic involvement [HI; n = 16 (48...
March 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/25511114/potential-drug-drug-interactions-in-infant-child-and-adolescent-patients-in-children-s-hospitals
#17
James Feinstein, Dingwei Dai, Wenjun Zhong, Jason Freedman, Chris Feudtner
BACKGROUND AND OBJECTIVES: Hospitalized infants, children, and adolescents are typically exposed to numerous distinct medications during inpatient admissions, increasing their risk of potential drug-drug interactions (PDDIs). We assessed the prevalence and characteristics of PDDI exposure of pediatric patients treated in children's hospitals. METHODS: This retrospective cohort study included patients <21 years old hospitalized in children's hospitals throughout the United States...
January 2015: Pediatrics
https://www.readbyqxmd.com/read/24725284/performance-of-anesthesia-residents-during-a-simulated-prone-ventricular-fibrillation-arrest-in-an-anesthetized-pediatric-patient
#18
Nancy M Tofil, Jennifer Dollar, Lynn Zinkan, Amber Q Youngblood, Dawn T Peterson, Marjorie L White, Timothy N Stooksberry, Seth A Jarrell, Collin King
BACKGROUND: Exposure to rare pediatric anesthesia emergencies varies depending on the residency program. Simulation can provide increased exposure to these rare events, improve performance of residents, and also aid in standardizing the curriculum. OBJECTIVE: The purpose of this study was to evaluate time to recognize and treat ventricular fibrillation in a pediatric prone patient and to expose learners to the difficulties of managing emergencies in prone patients...
September 2014: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/24447308/acidosis-and-hyperkalemia-caused-by-losartan-and-enalapril-in-pediatric-kidney-transplant-recipients
#19
Hale Sakallı, Esra Baskın, Umut Selda Bayrakcı, Gökhan Moray, Mehmet Haberal
OBJECTIVES: To evaluate the efficacy and safety of losartan and enalapril in pediatric kidney transplant recipients. MATERIALS AND METHODS: A retrospective review was performed in 31 pediatric kidney transplant recipients who were treated with losartan (50 mg/d, oral) for 1 to 6 months because of mild hypertension and persistent proteinuria. All patients were treated concurrently with enalapril (5 or 10 mg daily, oral), and 12 patients (39%) also were treated with amlodipine (5 or 10 mg daily, oral)...
August 2014: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/24405303/hyperkalemic-cardiac-arrest-in-pediatric-patients-undergoing-massive-transfusion-unplanned-emergencies
#20
EDITORIAL
Deborah Sesok-Pizzini, Mark-Alan Pizzini
No abstract text is available yet for this article.
January 2014: Transfusion
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