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Sonja Sulkava, Hanna M Ollila, Jukka Alasaari, Sampsa Puttonen, Mikko Härmä, Katriina Viitasalo, Alexandra Lahtinen, Jaana Lindström, Auli Toivola, Raimo Sulkava, Mika Kivimäki, Jussi Vahtera, Timo Partonen, Kaisa Silander, Tarja Porkka-Heiskanen, Tiina Paunio
STUDY OBJECTIVES: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift work. METHODS: We assessed intolerance to shift work with job-related exhaustion symptoms in shift workers using the emotional exhaustion subscale of the Maslach Burnout Inventory - General Survey, and carried out a genome-wide association study (GWAS) using Illumina's Human610-Quad BeadChip (n = 176)...
October 10, 2016: Sleep
E A Haapala, A Viitasalo, T Venäläinen, A-M Eloranta, J Ågren, V Lindi, T A Lakka
AIM: Polyunsaturated fatty acids are essential nutrients for the normal development of the brain. We investigated the associations between plasma polyunsaturated fatty acids and cognition in normal weight and overweight children. METHODS: The study recruited 386 normal weight children and 58 overweight children aged six to eight years and blood samples were drawn after a 12-hour fast. We assessed plasma polyunsaturated fatty acids using gas chromatography, cognition using Raven's Coloured Progressive Matrices, and overweight and obesity using the age-specific and sex-specific cut-offs from the International Obesity Task Force...
December 2016: Acta Paediatrica
Taisa M Venäläinen, Anna M Viitasalo, Ursula S Schwab, Aino-Maija Eloranta, Eero A Haapala, Henna P Jalkanen, Vanessa Df de Mello, David E Laaksonen, Virpi I Lindi, Jyrki J Ågren, Timo A Lakka
BACKGROUND: Evidence on the effects of lifestyle interventions on plasma fatty acid composition in children is limited. OBJECTIVE: We investigated the effects of a dietary and physical activity intervention on plasma fatty acid composition of cholesteryl esters (CEs) and phospholipids and estimated desaturase and elongase activities in children. DESIGN: We conducted a 2-y controlled dietary and physical activity intervention based on Finnish nutrition and physical activity recommendations in a population sample of 506 children aged 6-8 y...
October 2016: American Journal of Clinical Nutrition
Viitasalo Anna, Eloranta Aino-Maija, Atalay Mustafa, Romeo Stefano, Pihlajamäki Jussi, Lakka Timo A
BackgroundWe studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of non-alcoholic fatty liver disease among adults. We also investigated the associations of a genetic risk score combining information from the MBOAT7, PNPLA3 and TM6SF2 polymorphisms with plasma ALT.MethodsWe performed a 2-year follow-up study in 467 Caucasian children aged 6-9 years, genotyped the MBOAT7, PNPLA3 and TM6SF2 polymorphisms, calculated a genetic risk score from these polymorphisms (scored 0-3) and assessed plasma ALT...
July 13, 2016: Pediatric Research
Linnea Äärelä, Samuli Nurminen, Laura Kivelä, Heini Huhtala, Markku Mäki, Anna Viitasalo, Katri Kaukinen, Timo Lakka, Kalle Kurppa
BACKGROUND: The prevalence and factors associated with transaminasemia in celiac disease are poorly known. AIMS: To investigate these issues in paediatric celiac patients and controls. METHODS: Alanine aminotransferase (ALT) was studied in 150 children with untreated celiac disease, 161 disease controls and 500 population-based controls. The association between ALT and clinical and histological variables and the effect of a gluten-free diet were investigated in celiac patients...
September 2016: Digestive and Liver Disease
Niina Lintu, Kai Savonen, Anna Viitasalo, Tuomo Tompuri, Jussi Paananen, Mika P Tarvainen, Timo Lakka
BACKGROUND: There are few studies on determinants of cardiorespiratory fitness (CRF) among girls and boys separately in population samples of children. METHODS: We therefore investigated the determinants of CRF, assessed by maximal workload per height using allometric scaling, in a population sample of 162 girls and 177 boys aged 6 to 8 years. We used automated bootstrap feature selection and linear regression models. RESULTS: The strongest determinants of CRF among girls were maximal heart rate (HR; standardized regression coefficient [β] = 0...
November 2016: Journal of Physical Activity & Health
Anu Vierola, Anna Liisa Suominen, Virpi Lindi, Anna Viitasalo, Tiina Ikävalko, Niina Lintu, Juuso Väistö, Jari Kellokoski, Matti Närhi, Timo A Lakka
UNLABELLED: We investigated the cross-sectional associations of sedentary behavior, physical activity, cardiorespiratory fitness, and body fat content with pain conditions in prepubertal children. The participants were a population sample of 439 children aged 6 to 8 years. Sedentary behavior, physical activity, and pain conditions were assessed using questionnaires, cardiorespiratory fitness using maximal cycle ergometer test, and body fat percentage using dual-energy X-ray absorptiometry...
July 2016: Journal of Pain: Official Journal of the American Pain Society
Anna Viitasalo, Aino-Maija Eloranta, Niina Lintu, Juuso Väistö, Taisa Venäläinen, Sanna Kiiskinen, Panu Karjalainen, Jaana Peltola, Eeva-Kaarina Lampinen, Eero A Haapala, Jussi Paananen, Ursula Schwab, Virpi Lindi, Timo A Lakka
OBJECTIVE: To investigate the effects of a long-term, individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet quality in children. METHODS: We carried out a 2-year intervention study in a population sample of 506 children aged 6-8years in Finland in 2007-2012. We allocated the participants at baseline in the intervention and control group. We assessed physical activity and sedentary behavior by questionnaires and diet by food records...
June 2016: Preventive Medicine
Tuomas V Kenttä, Bruce D Nearing, Kimmo Porthan, Jani T Tikkanen, Matti Viitasalo, Markku S Nieminen, Veikko Salomaa, Lasse Oikarinen, Antti Jula, Kimmo Kontula, Chris Newton-Cheh, Heikki V Huikuri, Richard L Verrier
BACKGROUND: Heterogeneity of depolarization and repolarization underlies the development of lethal arrhythmias. OBJECTIVE: We investigated whether quantification of spatial depolarization and repolarization heterogeneity identifies individuals at risk for sudden cardiac death (SCD). METHODS: Spatial R-, J-, and T-wave heterogeneity (RWH, JWH, and TWH, respectively) was analyzed using automated second central moment analysis of standard digital 12-lead electrocardiograms in 5618 adults (2588, 46% men; mean ± SEM age 50...
March 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Hanna Lantto, Tomi S Mikkola, Pauliina Tuomikoski, Matti Viitasalo, Heikki Väänänen, Anssi R A Sovijärvi, Petri Haapalahti
OBJECTIVE: Menopausal hot flushes are associated with elevated activity of the sympathetic nervous system and may be related to increased risk for cardiovascular events. Sympathetic activation may trigger severe arrhythmias by modulating cardiac repolarization. The aim of this study was to evaluate the impact of hot flushes on cardiac repolarization in postmenopausal women with and without hot flushes. METHODS: We assessed 150 recently postmenopausal healthy women-72 with hot flushes and 78 without hot flushes...
May 2016: Menopause: the Journal of the North American Menopause Society
A Viitasalo, J Ågren, T Venäläinen, J Pihlajamäki, J Jääskeläinen, A Korkmaz, M Atalay, T A Lakka
BACKGROUND: Irisin has been suggested to protect against overweight. There are no previous data on the association of plasma fatty acid (FA) composition with plasma irisin. OBJECTIVES: We studied the association of FA composition with plasma irisin in normal weight and overweight/obese children. METHODS: This cross-sectional study included pre-pubertal children (388 normal weight children and 55 overweight/obese children); 6-9 years of age, taking part in the Physical Activity and Nutrition in Children Study...
2016: Pediatric Obesity
A Veijalainen, T Tompuri, E A Haapala, A Viitasalo, N Lintu, J Väistö, T Laitinen, V Lindi, T A Lakka
Associations of cardiorespiratory fitness (CRF), physical activity (PA), sedentary behavior, and body fat percentage (BF%) with arterial stiffness and dilation capacity were investigated in 160 prepubertal children (83 girls) 6-8 years of age. We assessed CRF (watts/lean mass) by maximal cycle ergometer exercise test, total PA, structured exercise, unstructured PA, commuting to and from school, recess PA and total and screen-based sedentary behavior by questionnaire, BF% using dual-energy X-ray absorptiometry, and arterial stiffness and dilation capacity using pulse contour analysis...
August 2016: Scandinavian Journal of Medicine & Science in Sports
Niina Viitasalo, Jouko Nätti
OBJECTIVE: To investigate the association of perceived age discrimination at work with subsequent long-term sickness absence among Finnish employees. METHODS: A representative sample of Finnish employees (n = 6322) was merged with register-based follow-up data. A negative binomial model was used in the analysis of subsequent sickness absence days. RESULTS: Perceived age discrimination was associated to long-term sickness absence after controlling various background, work, and health-related factors...
July 2015: Journal of Occupational and Environmental Medicine
Raisa Turja, Kari K Lehtonen, Axel Meierjohann, Jenny-Maria Brozinski, Emil Vahtera, Anna Soirinsuo, Alexander Sokolov, Pauline Snoeijs, Hélène Budzinski, Marie-Hélène Devier, Laurent Peluhet, Jari-Pekka Pääkkönen, Markku Viitasalo, Leif Kronberg
Biological effects of wastewater treatment plant (WWTP) effluents were investigated in Baltic mussels (Mytilus trossulus) caged for one month 800m and 1100m from the WWTP discharge site and at a reference site 4km away. Significant antioxidant, genotoxic and lysosomal responses were observed close to the point of the WWTP discharge. Passive samplers (POCIS) attached to the cages indicated markedly higher water concentrations of various pharmaceuticals at the two most impacted sites. Modeling the dispersal of a hypothetical passive tracer compound from the WWTP discharge site revealed differing frequencies and timing of the exposure periods at different caging sites...
August 15, 2015: Marine Pollution Bulletin
Mikael Koponen, Annukka Marjamaa, Anita Hiippala, Juha-Matti Happonen, Aki S Havulinna, Veikko Salomaa, Annukka M Lahtinen, Taina Hintsa, Matti Viitasalo, Lauri Toivonen, Kimmo Kontula, Heikki Swan
BACKGROUND: Inherited long-QT syndrome (LQTS) is associated with risk of sudden death. We assessed the clinical course and the fulfillment of current treatment strategies in molecularly defined pediatric LQTS type 1 and (LQT1) and type 2 (LQT2) patients. METHODS AND RESULTS: Follow-up data covering a mean of 12 years were collected for 316 genotyped LQT1 and LQT2 patients aged 0 to 18 years. No arrhythmic deaths occurred during the follow-up. Finnish KCNQ1 and KCNH2 founder mutations were associated with fewer cardiac events than other KCNQ1 and KCNH2 mutations (hazard ratio [HR], 0...
August 2015: Circulation. Arrhythmia and Electrophysiology
Eero A Haapala, Niina Lintu, Juuso Väistö, Leah E Robinson, Anna Viitasalo, Virpi Lindi, Timo A Lakka
OBJECTIVES: To investigate the independent and combined associations of cardiorespiratory performance (CP), neuromuscular performance (NP; including motor performance [MP]) and body fat percentage (BF%) with cognition in children. METHODS: The participants were 202 boys and 201 girls age 6-8 yr. Cardiorespiratory performance was assessed using maximal cycle ergometer test and was expressed as maximal workload per lean body mass. Neuromuscular performance score included muscle strength, speed, agility, balance, manual dexterity, and flexibility; and MP included speed and agility, balance, and manual dexterity...
October 2015: Medicine and Science in Sports and Exercise
Inese Huttunen, Heikki Lehtonen, Markus Huttunen, Vanamo Piirainen, Marie Korppoo, Noora Veijalainen, Markku Viitasalo, Bertel Vehviläinen
Climate change is expected to increase annual and especially winter runoff, shorten the snow cover period and therefore increase both nutrient leaching from agricultural areas and natural background leaching in the Baltic Sea catchment. We estimated the effects of climate change and possible future scenarios of agricultural changes on the phosphorus and nitrogen loading to the Baltic Sea from Finnish catchments. In the agricultural scenarios we assumed that the prices of agricultural products are among the primary drivers in the adaptation to climate change, as they affect the level of fertilization and the production intensity and volume and, hence, the modeled changes in gross nutrient loading from agricultural land...
October 1, 2015: Science of the Total Environment
Katri Hemiö, Sampsa Puttonen, Katriina Viitasalo, Mikko Härmä, Markku Peltonen, Jaana Lindström
OBJECTIVES: Over 20% of employees in Europe work in shifts. Shift work increases the risk for chronic diseases, but a healthy lifestyle may attenuate the adverse effect of shift work. The aim of this study was to explore food and nutrient intake differences between working time groups. METHODS: The participants were 1478 employees (55% of men) of an airline divided into three working time groups: day work (n=608), shift work without in-flight work (n=541) and in-flight work (n=329)...
July 2015: Occupational and Environmental Medicine
Anna Viitasalo, Mustafa Atalay, Jussi Pihlajamäki, Jarmo Jääskeläinen, Ayhan Korkmaz, Dorota Kaminska, Virpi Lindi, Timo A Lakka
BACKGROUND: There are no previous data on the association of PNPLA3 I148M polymorphism (rs738409) with circulating adipokines and myokines in children. SUBJECTS/METHODS: Subjects were a population sample of 481 Caucasian children aged 6-8 years. We assessed circulating levels of irisin together with IL-6, TNF-α, leptin, high molecular weight (HMW)-adiponectin, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) while the subjects were stratified according to PNPLA3 I148M variants...
July 2015: Metabolism: Clinical and Experimental
Tuomas Kenttä, Kimmo Porthan, Jani T Tikkanen, Heikki Väänänen, Lasse Oikarinen, Matti Viitasalo, Hannu Karanko, Maarit Laaksonen, Heikki V Huikuri
BACKGROUND: Early repolarization (ER) is defined as an elevation of the QRS-ST junction in at least two inferior or lateral leads of the standard 12-lead electrocardiogram (ECG). Our purpose was to create an algorithm for the automated detection and classification of ER. METHODS: A total of 6,047 electrocardiograms were manually graded for ER by two experienced readers. The automated detection of ER was based on quantification of the characteristic slurring or notching in ER-positive leads...
July 2015: Annals of Noninvasive Electrocardiology
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