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pediatric hyponatremia

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https://www.readbyqxmd.com/read/27916376/factors-predictive-of-complicated-appendicitis-in-children
#1
Xuan-Binh D Pham, Veronica F Sullins, Dennis Y Kim, Blake Range, Amy H Kaji, Christian M de Virgilio, Steven L Lee
BACKGROUND: The ability to predict whether a child has complicated appendicitis at initial presentation may influence clinical management. However, whether complicated appendicitis is associated with prehospital or inhospital factors is not clear. We also investigate whether hyponatremia may be a novel prehospital factor associated with complicated appendicitis. MATERIALS AND METHODS: A retrospective review of all pediatric patients (≤12 y) with appendicitis treated with appendectomy from 2000 to 2013 was performed...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27888815/acute-diarrhoea-induced-by-rotavirus-in-children-hospitalysed-in-provincial-hospital-for-infectious-diseases-in-bydgoszcz-in-2014-year
#2
Beata Smok, Katarzyna Zieniewicz-Cieślik, Ewa Smukalska, Małgorzata Pawłowska
OBJECTIVE: The aim of the present study was to describe the epidemiology and course of rotavirus infection in children hospitalized at the T. Browicz Provincial Hospital for Infectious Diseases in Bydgoszcz, Poland in 2014 year. INTRODUCTION: Rotavirus infection is responsible for over 2 millions hospitalizations per year among children under 5 year old. Rotavirus gastroenterocolitis is one of the most common cause of severe dehydration, electrolyte disturbances and metabolic acidosis, leading to 400-600 thousand deaths per year in children younger than 5 years of age worldwide...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27836006/mycoplasma-pneumoniae-associated-mild-encephalitis-encephalopathy-with-a-reversible-splenial-lesion-report-of-two-pediatric-cases-and-a-comprehensive-literature-review
#3
Norishi Ueda, Satoshi Minami, Manabu Akimoto
BACKGROUND: No literature review exists on Mycoplasma pneumoniae-associated mild encephalitis/encepharopathy with a reversible splenial lesion (MERS). METHODS: M.pneumoniae-associated MERS cases were searched till August 2016 using PubMed/Google for English/other-language publications and Ichushi ( http://www.jamas.or.jp/ ) for Japanese-language publications. Inclusion criteria were children fulfilling definition for encephalitis, M.pneumoniae infection, and neuroimaging showing hyperintensity in the splenium of the corpus callosum (SCC) alone (type I) or SCC/other brain areas (type II)...
November 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27829716/association-of-hyponatremia-with-in-hospital-outcomes-in-infective-endocarditis-a-5-year-review-from-an-indian-intensive-care-unit
#4
Saraschandra Vallabhajosyula, Muralidhar D Varma, Shashaank Vallabhajosyula, Saarwaani Vallabhajosyula
Hyponatremia is commonly noted with cardiovascular disorders, but its role in infective endocarditis (IE) is limited to being a marker of increased morbidity in IE patients with intravenous drug use. This was a 5-year retrospective review from an Indian Intensive Care Unit (ICU). Patients >18 years with IE and available serum sodium levels were included in the study. Pediatric and pregnant patients were excluded from the study. Hyponatremia was defined as admission sodium <135 mmol/L. Detailed data were abstracted from the medical records...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27769855/acute-intermittent-porphyria-in-children-a-case-report-and-review-of-the-literature
#5
Manisha Balwani, Preeti Singh, Anju Seth, Ekta Malik Debnath, Hetanshi Naik, Dana Doheny, Brenden Chen, Makiko Yasuda, Robert J Desnick
Acute Intermittent Porphyria (AIP), an autosomal dominant inborn error of heme metabolism, typically presents in adulthood, most often in women in the reproductive age group. There are limited reports on the clinical presentation in children, and in contrast to the adults, most of the reported pediatric cases are male. While acute abdominal pain is the most common presenting symptom in children, seizures are commonly seen and may precede the diagnosis of AIP. As an example, we report a 9year old developmentally normal pre-pubertal boy who presented with acute abdominal pain, vomiting and constipation followed by hyponatremia, seizures, weakness and neuropathy...
October 15, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27610358/use-of-hypotonic-maintenance-intravenous-fluids-and-hospital-acquired-hyponatremia-remain-common-in-children-admitted-to-a-general-pediatric-ward
#6
Shikha Shukla, Srikanta Basu, Michael L Moritz
AIM: To evaluate maintenance intravenous fluid-prescribing practices and the incidence of hospital-acquired hyponatremia in children admitted to a general pediatric ward. METHODS: This is a prospective observational study conducted over a 2-month period in children ages 2 months to 5 years who were admitted to a general pediatric ward and who were receiving maintenance intravenous fluids. The composition, rate, and duration of intravenous fluids were chosen at the discretion of the treating physician...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27603336/cerebral-salt-wasting-syndrome-in-a-child-with-wernicke-encephalopathy-treated-with-fludrocortisone-therapy-a-case-report
#7
Min Jeong Han, Soon Chul Kim, Chan Uhng Joo, Sun Jun Kim
RATIONALE FOR THIS CASE REPORT: Cerebral Salt-Wasting Syndrome (CSWS) is characterized by hyponatremia and sodium wasting in the urine. These conditions are triggered by various neurosurgical disorders such as subarachnoid hemorrhage, brain tumor, head injury, and brain surgery. To our knowledge, CSWS caused by Wernicke encephalopathy (WE) has been rarely reported. PRESENTING CONCERNS OF THE PATIENT: A 2-year-old male patient presented to our hospital due to a seizure attack...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27603309/sodium-disturbances-in-children-admitted-to-a-kenyan-hospital-magnitude-outcome-and-associated-factors
#8
Fredrick Ibinda, Hans-Christoph Zarnack, Charles R Newton
BACKGROUND: Perturbations of blood sodium are the most frequently encountered electrolyte disorder in sick children, and may influence fluid therapy. We examined the frequency of blood sodium perturbations, and factors and outcomes associated with hyponatremia in children admitted to a rural Kenyan hospital and investigated the risk factors associated with deaths in hyponatremic children. METHODS: Plasma sodium levels and other laboratory parameters were measured in children admitted to a rural Kenyan hospital...
2016: PloS One
https://www.readbyqxmd.com/read/27591118/reversible-splenial-lesion-syndrome-in-children-retrospective-study-and-summary-of-case-series
#9
Wen-Xiong Chen, Hong-Sheng Liu, Si-Da Yang, Si-Hui Zeng, Yuan-Yuan Gao, Zhi-Hong Du, Xiao-Jing Li, Hai-Sheng Lin, Hui-Ci Liang, Jian-Ning Mai
OBJECTIVE: To describe clinical features of reversible splenial lesion syndrome (RESLES) in children. METHODS: Retrospectively analyzed clinical features of RESLES in children and compared differences between severe and non-severe group, classified by clinical global impression-scale; summarized clinical features of children with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) from case series. RESULTS: 16 episodes of RESLES occurring in 15 Chinese children were analyzed, with 13 episodes having MERS and 3 episodes with epilepsy...
November 2016: Brain & Development
https://www.readbyqxmd.com/read/27507877/phase-i-study-of-selinexor-a-selective-inhibitor-of-nuclear-export-in-combination-with-fludarabine-and-cytarabine-in-pediatric-relapsed-or-refractory-acute-leukemia
#10
Thomas B Alexander, Norman J Lacayo, John K Choi, Raul C Ribeiro, Ching-Hon Pui, Jeffrey E Rubnitz
Purpose To characterize the toxicity, pharmacokinetics, and pharmacodynamics of selinexor, a selective inhibitor of nuclear export, when combined with fludarabine and cytarabine, in children with relapsed or refractory leukemia. Patients and Methods Eighteen patients with relapsed or refractory acute leukemia were enrolled in the SELHEM (Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome) clinical trial (NCT02212561). Selinexor, initially at 30 mg/m(2) per dose, was given orally on days 1, 3, 8, 10, 22, and 24 and was escalated according to a rolling-six design...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27478556/enteroviral-meningitis-in-neonates-and-children-of-mashhad-iran
#11
Mohammad Javad Ghabouli Shahroodi, Kiarash Ghazvini, Reza Sadeghi, Mohammad Saeed Sasan
BACKGROUND: The highest incidence of meningitis occurs during the neonatal period and (then) infancy. Although Bacterial agents are the most dangerous cause of neonatal and childhood meningitis yet viruses especially, enteroviruses (EV), are by far the most common cause of meningitis in this age group. OBJECTIVES: The aim of the current study was to evaluate the role of EVs in neonatal and childhood meningitis in the Mashhad city of Iran. MATERIALS AND METHODS: This was a descriptive study that was performed at Imam Reza hospital in a period of six months (March to September 2007), during which all of the cerebral spinal fluid (CSF) samples from the neonatal intensive care unit (NICU) and pediatrics ward were collected and real time-polymerase chain reaction (RT-PCR) for EVs was done on these samples...
May 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27471737/suitable-intravenous-fluid-for-preventing-dysnatremia-in-children-with-gastroenteritis-a-randomized-clinical-trial
#12
Kioomars Golshekan, Hamidreza Badeli, Mahboube Miri, Maryam Mirzaie, Afagh Hassanzadeh Rad, Fatemeh Salamat, Sepideh Abdi Tazeabadi, Nahid Bidar, Kobra Blouki-Moghaddam, Houman Hashemian
INTRODUCTION: Gastroenteritis (GE) is one of the most common pediatric diseases. Hyponatremia commonly occurs by administering hypotonic fluids to GE and hospitalized children. Yet, there is no consensus on the ideal method of treatment. OBJECTIVES: we aimed to assess suitable intravenous (IV) fluid for preventing dysnatremia in children with GE. PATIENTS AND METHODS: This is a double blind randomized clinical trial, which was conducted on infants of 6 months up to 14 years children with GE...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27461484/hypotonic-fluid-reduce-serum-sodium-compared-to-isotonic-fluids-during-anesthesia-induction-in-pediatric-patients-undergoing-maxillofacial-surgery-type-of-infusion-affects-blood-electrolytes-and-glucose-an-observational-study
#13
Kentaro Ouchi, Kazuna Sugiyama
BACKGROUND: Reportedly, administration of hypotonic fluids containing 30.8-74 mEq/L sodium with 5 % glucose may lead to serious hyponatremia or hyperglycemia. In Japan, hypotonic fluids containing 90 mEq/L sodium with 2.6 % glucose are commonly used. We compared blood electrolyte balance and blood glucose concentration with the use of isotonic (140 mEq/L sodium with 1 % glucose) versus hypotonic fluids in pediatric patients. METHODS: We studied 77 children aged 5 months to 2 years who underwent oro-maxillofacial surgery and dental treatment under general anesthesia...
July 27, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27383523/mechanism-of-hyponatremia-in-community-acquired-pneumonia-does-b-type-natriuretic-peptide-play-a-causative-role
#14
Moran Hausman-Kedem, Shimon Reif, Dana Danino, Rona Limor, Zachary M Grinspan, Anat Yerushalmi-Feler, Amir Ben-Tov, Amir Birger
OBJECTIVE: Hyponatremia is a well-known sequela of community-acquired pneumonia (CAP). B-type natriuretic peptide (BNP) has a natriuretic effect and was found to be elevated in patients with CAP. We investigated whether BNP has a role in the pathophysiology of hyponatremia in pediatric CAP. METHODS: Serum and urine electrolytes and osmolality, as well as NT-pro-BNP (N-BNP), were obtained in 49 hospitalized pediatric patients with CAP (29 with hyponatremia, 20 with normal sodium levels...
May 31, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27352842/clinico%C3%A2-%C3%A2-laboratory-profile-of-scrub-typhus-an-emerging-rickettsiosis-in-india
#15
Dinesh Kumar Narayanasamy, Arul Kumaran Arunagirinathan, Revathi Krishna Kumar, V D Raghavendran
OBJECTIVE: To study the clinical and laboratory profile of pediatric scrub typhus in rural south India. METHODS: This is a descriptive study of the clinical and laboratory features of 117 children with IgM ELISA proven scrub typhus out of 448 children, who were admitted in the Pediatric ward of a tertiary care hospital, during the study period of November 2014 through March 2015. RESULTS: Fever was present in all 117 children, with mean duration of fever at admission as 9 d...
November 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27253356/treatment-of-severe-hypervolemic-hyponatremia-in-a-child-with-pneumonia
#16
Teresa Genoni, Rossana Tenconi, Giuseppe Bertolozzi, Emanuela Anna Laicini, Giacomo Tardini, Federica Vianello, Ernesto Leva, Gregorio Paolo Milani, Emilio Filippo Fossali
A 21-month-old boy came to our attention because of pneumonia. His weight increased before presentation, and his blood test results showed hyponatremia (116 mEq/L), low plasma osmolarity (241 mOsm/L), and high urine osmolarity (435 mOsm/L). He was treated with 0.9% sodium chloride solution and intravenous furosemide, and sodium levels rose up to 135 mEq/L in 36 hours. No standard treatment is available for severe hyponatremia in children. The use of vaptans in pediatric patients is described in literature, but it lacks evidence about safety and effectiveness...
June 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27230223/describing-kawasaki-shock-syndrome-results-from-a-retrospective-study-and-literature-review
#17
Andrea Taddio, Eleonora Dei Rossi, Lorenzo Monasta, Serena Pastore, Alberto Tommasini, Loredana Lepore, Gabriele Bronzetti, Edoardo Marrani, Biancamaria D'Agata Mottolese, Gabriele Simonini, Rolando Cimaz, Alessandro Ventura
Kawasaki shock syndrome (KSS) is a rare manifestation of Kawasaki disease (KD) characterized by systolic hypotension or clinical signs of poor perfusion. The objectives of the study are to describe the main clinical presentation, echocardiographic, and laboratory findings, as well as the treatment options and clinical outcomes of KSS patients when compared with KD patients. This is a retrospective study. All children referred to two pediatric rheumatology units from January 1, 2012, to December 31, 2014, were enrolled...
May 26, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27125438/common-finding-of-mild-hyponatremia-in-children-evaluated-at-the-emergency-department-and-its-correlation-with-plasma-c-reactive-protein-values
#18
Dimitri Poddighe
BACKGROUND: In the context of infectious diseases, mild hyponatremia is supposed to be originated by a transient secretion of vasopressin mediated by non-osmotic stimuli. This study provides data supporting the view that mild hyponatremia during acute illnesses is related to a systemic inflammatory condition. METHODS: A total of 328 consecutive children (aged 3 months to 17 years) underwent blood testing at the Pediatric Emergency Department over a 2-month period and were retrospectively analyzed...
June 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27115479/methylphenidate-overdose-causing-secondary-polydipsia-and-severe-hyponatremia-in-an-8-year-old-boy
#19
Vanisha Patel, Ashwin Subramani Krishna, Cassandra Lefevre, Mildred Kaagaza, Michael Wittkamp
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is an increasingly common diagnosis of childhood that manifests with symptoms that affect cognitive, academic, behavioral, emotional, and social functioning. There are a multitude of pharmaceutical therapies to choose from when managing this condition, and though many studies on the safety and efficacy of these medications have been published, adverse effects still occur. CASE: This case discusses a previously healthy 8-year-old boy who had been prescribed 20-mg lisdexamfetamine dimesylate for ADHD however mistakenly took his brother's 36-mg methylphenidate extended-release tablets, resulting in hyperhidrosis, excessive thirst, polydipsia, and combative behavior that began within 3 hours of ingestion...
April 26, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27086496/la-crosse-encephalitis-an-adult-case-series
#20
Amy Lynn A Teleron, Brandon K Rose, David M Williams, Suzanne E Kemper, James E McJunkin
BACKGROUND: La Crosse viral encephalitis is well described in children, but to date, there are only 2 adult cases described in the literature. Despite the fact that pediatric infection can be life threatening and typically presents as a febrile meningoencephalitis often complicated by seizures and mental status changes, little is known about the presentation and course of adult infection. We report the largest case series of adult La Crosse encephalitis. METHODS: Inpatient data were reviewed between 2001 and 2012 to identify adults (≥18 years of age) with possible La Crosse encephalitis...
August 2016: American Journal of Medicine
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