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https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#1
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29676107/-expert-consensus-on-prescription-comment-of-chinese-traditional-patent-medicine-for-promoting-the-rational-use-of-drugs-in-beijing
#2
Rui Jin, Kui-Jun Zhao, Gui-Ming Guo, Bing Zhang, Yu-Guang Wang, Chun-Miao Xue, Yi-Heng Yang, Li-Xia Wang, Guo-Hui Li, Jin-Fa Tang, Li-Xing Nie, Xiang-Lin Zhang, Ting-Ting Zhao, Yi Zhang, Can Yan, Suo-Zhong Yuan, Lu-Lu Sun, Xing-Zhong Feng, Dan Yan
With the growth of number of Chinese patent medicines and clinical use, the rational use of Chinese medicine is becoming more and more serious. Due to the complexity of Chinese medicine theory and the uncertainty of clinical application, the prescription review of Chinese patent medicine always relied on experience in their respective, leading to the uncontrolled of clinical rational use. According to the traditional Chinese medicine (TCM) theory and characteristics of the unique clinical therapeutics, based on the practice experience and expertise comments, our paper formed the expert consensus on the prescription review of Chinese traditional patent medicine for promoting the rational use of drugs in Beijing...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#3
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29671355/hdac-inhibitors-a-2013-2017-patent-survey
#4
Micaela Faria Freitas, Muriel Cuendet, Philippe Bertrand
Zinc-dependent histone deacetylases (HDAC) inhibitors represent an important class of biologically active compounds with four of them approved by the FDA. A wide range of molecules has been reported for applications in several human diseases.Area covered: This review covers recent efforts in the synthesis and applications of HDAC inhibitors from 2013-2017.Expert opinion: HDAC inhibitors represent an important class of biologically active compounds for single or combination therapies. The current synthetic methodologies are oriented towards selective HDAC isoforms to achieve better therapeutic effects...
April 19, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29663292/the-potential-role-of-sglt2-inhibitors-in-the-treatment-of-type-1-diabetes-mellitus
#5
Hadi Fattah, Volker Vallon
Type 1 diabetes mellitus is a difficult disease to treat due to the relative paucity of therapeutic options other than injectable insulin. The latter, however, can induce hypoglycemia, which has been linked to enhanced cardiovascular risk. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-hyperglycemic medications that do not increase the hypoglycemia risk and are US Food and Drug Administration (FDA) approved in type 2 diabetes mellitus. SGLT2 inhibitors may also be of benefit in type 1 diabetic patients, in addition to insulin, although they have not yet been approved for this indication...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29649907/farnesoid-x-receptor-modulators-2014-present-a-patent-review
#6
Valentina Sepe, Eleonora Distrutti, Stefano Fiorucci, Angela Zampella
The nuclear receptor FXR regulates the expression of genes involved in bile acids, glucose and lipid homeostasis. For its role as guardian of metabolism, FXR has been identified a promising pharmacological target in liver bile acid and lipid accumulation, such as cholestasis and non-alcoholic fatty liver disease (NAFLD). The field of FXR research is extremely competitive with a large number of patents and articles published in the last decades identifying promising hit compounds. Areas covered. The present review summarizes recent patent activity (2014-to date) filing for synthetic and natural FXR ligands, including bile acid derivatives and non-steroidal compounds, alongside their in vitro and in vivo efficacy as well as their therapeutic applications...
April 13, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#7
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29620651/treatment-of-giant-cavernous-aneurysm-in-an-elderly-patient-via-extracranial-intracranial-saphenous-vein-bypass-graft-in-a-hybrid-operating-room-a-case-report
#8
Can Xin, Jianjian Zhang, Zhengwei Li, Zhongwei Xiong, Bangkun Yang, Xiaolin Wu, Hao Wang, Yichun Zou, Rongqing Wu, Wenyuan Zhao, Jincao Chen
RATIONALE: Extracranial-intracranial saphenous vein bypass (EC-IC SVB) remains indispensable for treating giant cavernous aneurysms. We report an unusual case of a giant cavernous aneurysm in an elderly patient treated with EC-IC SVB in a hybrid operating room. Immediately following proximal ligation of the internal carotid artery (ICA), she suffered an acute intraoperative encephalocele. PATIENT CONCERNS: A 71-year-old woman had suffered from severe headache and double vision for 4 months...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29611489/nanocarriers-for-the-effective-treatment-of-cervical-cancer-research-advancements-and-patent-analysis
#9
Nida Akhtar, Kamla Pathak
BACKGROUND: Cervical cancer being the cancer of cervix is caused by the aberrant cell growth that acquires an ability to spread/ invade to other body parts as well. It has been reported to be the second most commonest cause of death and cancer as well among women. Based on the severity of the disease, treatment aspect needs to be explored more in order to overcome the limitations acquired by conventional treatment. Recently, nanocarriers based drug delivery systems including liposomes, nanofibres, metallic NPs, polymeric NPs, dendrimers, polymeric micelles, antibody-drug conjugates etc...
April 2, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29611470/polymeric-immunonanoparticles-mediated-cancer-therapy-versatile-nanocarriers-for-cell-specific-cargo-delivery
#10
Namdev L Dhas, Ritu R Kudarha, Niyati S Acharya, Sanjeev R Acharya
The major drawback with conventional therapeutic approaches for cancer therapy is decreased efficacy and redundant therapy associated toxicity and side effects causing increased patient discomfort. With the aim of minimizing these limitations, a vast amount of attention has been given to targeted nanocarrier-based drug delivery systems that possess a several-fold advantage over conventional therapy. Increased research in targeted nanoparticulate systems has led to the development of immunonanoparticles with enhanced efficacy and targeting efficiency along with decreased drug-resistant cancer- and dose-related toxicity...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29602258/patent-foramen-ovale-pfo-closure-versus-medical-therapy-for-prevention-of-recurrent-stroke-in-patients-with-prior-cryptogenic-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Anthony K Akobeng, Ibtihal Abdelgadir, Younes Boudjemline, Ziyad M Hijazi
OBJECTIVES: We performed a systematic review and meta-analysis of randomized controlled trials to assess the effect of closure of a patent foramen ovale (PFO) compared with medical therapy for the prevention of stroke in patients with prior cryptogenic stroke. BACKGROUND: The role of PFO closure in reducing risk of stroke in patients with prior cryptogenic stroke has been controversial. METHODS: We searched PubMed, Embase, CINAHL, and CENTRAL for randomized trials investigating PFO closure versus medical therapy...
March 30, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29589551/recent-patents-on-polymeric-nanoparticles-for-cancer-therapy
#12
Parijat Pandey, Harish Dureja
BACKGROUND: Cancer is a major problem which has claimed so many lives throughout the world. Though anumber of resources have been utilized for development of cancer therapeutics, no effective cure has been found so far. OBJECTIVE: Therefore, the need for looking at evolving technologieshas become very important to get a solution for this problem. Among these, nanotechnology has got so much popularity and became feasible in the past few years. Nanotechnology is presentlyused as a most preferable drug delivery platform for cancer therapy...
March 27, 2018: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/29580939/non-pharmacological-management-of-a-hemodynamically-significant-patent-ductus-arteriosus
#13
A Smith, P J McNamara, A F El-Khuffash
The association between the patent ductus arteriosus (PDA) and neonatal morbidity, mortality and poor neurodevelopmental outcome in later childhood has been the focus of intense debate for decades. The lack of evidence supporting therapeutic strategies aimed at achieving PDA closure has led to the widespread adoption of conservative management aimed at mitigating the impact of shunt volume without achieving ductal closure. In this article, we review this management approach, describe the supportive evidence and potential complications associated with this strategy...
March 16, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29570428/intravascular-cooling-catheter-related-venous-thromboembolism-after-hypothermia-a-case-report-and-review-of-the-literature
#14
Xuan Wang, Brian T Moy, Brett J Hiendlmayr, Felix Krainski, W Lane Duvall, Antonio B Fernandez
Fifty-four year-old man with recent history of myocardial infarction and a percutaneous coronary intervention who suffered a ventricular fibrillation arrest at home. He was resuscitated in the field. His heart rhythm was in atrial fibrillation. The cardiac catheterization showed a patent stent from his previous myocardial infarction and no new occlusions. He subsequently underwent hypothermia protocol using the Alsius CoolGard 3000 Temperature Control System and Icy Catheter. Heparin drip was started for atrial fibrillation 36 hours after catheter insertion and became therapeutic 2 hours before the end of cooling maintenance phase...
March 23, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29568659/primary-nocardia-infection-causing-a-fluorodeoxyglucose-avid-right-renal-mass-in-a-redo-lung-transplant-recipient
#15
Sreeja Biswas Roy, Mitchell D Ross, Pradnya D Patil, Richard Trepeta, Ross M Bremner, Tanmay S Panchabhai
Immunosuppression after lung transplantation may increase susceptibility to opportunistic infection and is associated with early and delayed deaths in lung transplant recipients. Factors that may predispose lung transplant recipients to opportunistic bacterial and fungal infections include prolonged corticosteroid use, renal impairment, treatment of acute rejection, and post-transplant diabetes mellitus. We present a unique case of a 63-year-old woman with diabetes mellitus who underwent redo lung transplantation...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29566578/aminobenzisoxazole-compounds-as-agonists-of-%C3%AE-7-nicotinic-acetylcholine-receptors-a-patent-evaluation-wo-2017027600
#16
Yang He, Jingshan Shen
alpha 7 subtype nicotinic acetylcholine receptor (α7 nAChR) ligands, that is, ligands that interact with the orthosteric or allosteric binding sites of α7 nAChR, hold great potential for several therapeutic applications. Numerous compounds have been designed targeting α7 nAChR but most of them cannot be used therapeutically for various reasons. Areas covered: The patent application describes a series of germinal substituted aminobenzisoxazole compounds as α7 nAChR ligands. These compounds were claimed as potential therapeutics for treating and/or improving cognitive function...
March 23, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29565037/circular-noncoding-rnas-as-potential-therapies-and-circulating-biomarkers-for-cardiovascular-diseases
#17
REVIEW
Ahmed S Bayoumi, Tatsuya Aonuma, Jian-Peng Teoh, Yao-Liang Tang, Il-Man Kim
Recent advancements in genome-wide analyses and RNA-sequencing technologies led to the discovery of small noncoding RNAs, such as microRNAs (miRs), as well as both linear long noncoding RNAs (lncRNAs) and circular long noncoding RNAs (circRNAs). The importance of miRs and lncRNAs in the treatment, prognosis and diagnosis of cardiovascular diseases (CVDs) has been extensively reported. We also previously reviewed their implications in therapies and as biomarkers for CVDs. More recently, circRNAs have also emerged as important regulators in CVDs...
March 22, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29559770/enhanced-gastric-therapeutic-effects-of-brucea-javanica-oil-and-its-gastroretentive-drug-delivery-system-compared-to-commercial-products-in-pharmacokinetics-study
#18
Yue Zhang, Liying Zhang, Qi Zhang, Xitong Zhang, Tong Zhang, Bing Wang
Background: Brucea javanica oil (BJO), a traditional Chinese herbal medicine, has a variety of pharmacological activities and several BJO-related patent drugs have been widely used in China. Purpose: The objective of this study was to evaluate the gastric therapeutic effects of self-made BJO and its pharmaceutical potential to formulate novel BJO gastroretentive floating bead by comparing with commercial products. Methods: BJO was extracted from the seeds of B...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29558289/therapeutic-potential-of-glycyrrhetinic-acids-a-patent-review-2010-2017
#19
Hidayat Hussain, Ivan R Green, Umair Shamraiz, Muhammad Saleem, Amin Badshah, Ghulam Abbas, Najeeb Ur Rehman, Muhammad Irshad
Glycyrrhetinic acids (GAs) viz., 18β-glycyrrhetinic acid and 18α-glycyrrhetinic acid, are oleanane-type triterpenes having a carboxylic acid group at C-30, and are extracted from the Chines herbal medicine licorice (Glycyrrhiza uralensis). Although the pharmacological properties of GAs have long been known, attention to them has greatly increased in recent times due to their cytotoxic activity. Areas Covered: This review represents the patents granted about natural and synthetic glycyrrhetinic acid analogs from January 2010 to December 2017, the advances made by research groups in conjunction with pharmaceutical companies in the discovery of new natural or synthetic glycyrrhetinic acid analogs...
March 20, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29558250/fatal-patent-troglostrongylosis-in-a-litter-of-kittens
#20
Donato Traversa, Leonardo Della Salda, Anastasia Diakou, Chiara Sforzato, Mariarita Romanucci, Antonio Frangipane di Regalbono, Raffaella Iorio, Valentina Colaberardino, Angela Di Cesare
Parasitic nematodes affecting the respiratory system of cats are gaining much attention in the scientific community and new knowledge has recently been acquired on their epizootiology, biology and clinical aspects. In particular, in the past few years, different studies have indicated that the metastrongyloid lungworm Troglostrongylus brevior can be vertically transmitted in cats, although information on its basic biology is still poor. The present paper describes a case of troglostrongylosis in a litter of three suckling kittens, with a focus on anatomo-pathological and biological features of the infection in two of these three animals...
March 20, 2018: Journal of Parasitology
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