keyword
https://read.qxmd.com/read/38527461/effects-of-onabotulinum-toxin-a-injection-on-sexual-function-in-women-with-refractory-interstitial-cystitis-bladder-pain-syndrome-a-prospective-study
#1
JOURNAL ARTICLE
Murat Can Karaburun, Eralp Kubilay, Derya Öztuna, Mehmet İlker Gökçe, Evren Süer, Ömer Gülpınar
OBJECTIVES: To determine the effect of intravesical onabotulinum toxin-A (BoNT-A) treatment on sexual functions in female patients with refractory interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: Female patients with IC/BPS refractory to previous treatments were included in the study between January 2020 and April 2022. Patients were treated with the trigone-sparing injection (Group 1) or trigone-included injection (Group 2) techniques. 100 Units of BoNT-A was applied submucosally on 20 different points...
March 2024: Lower Urinary Tract Symptoms
https://read.qxmd.com/read/38526326/identification-of-key-pathways-and-mrnas-in-interstitial-cystitis-bladder-pain-syndrome-treatment-with-quercetin-through-bioinformatics-analysis-of-mrna-sequence-data
#2
JOURNAL ARTICLE
Guang Wang, Pei Li, Si-Wei Su, Rui Xu, Zi-Ye Huang, Tong-Xin Yang, Jiong-Ming Li
BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition with painful bladder. At present, the pathogenesis of IC/BPS is still unknown. Quercetin (QCT) is a kind of natural flavonoid with wide sources and multiple biological activities. The purpose of this study was to explore the effects of QCT on mRNA expression and related regulatory signal pathways in IC model rats. METHODS: LL-37 was used to induce the IC/BPS model rats. 20 mg/kg QCT was injected intraperitoneally into IC/BPS rats...
March 22, 2024: Aging
https://read.qxmd.com/read/38515245/psychosexological-correlates-of-372-women-with-vulvodynia-overactive-pelvic-floor-postcoital-cystitis-and-interstitial-cystitis
#3
JOURNAL ARTICLE
Noemi Ricucci, Elena Colonnello, Erika Limoncin, Daniele Mollaioli, Andrea Sansone, Emmanuele A Jannini, Giacomo Ciocca
BACKGROUND: Among the plethora of urogynecological conditions possibly affecting women, some of them, less explored, have significant impacts on sexological and psychological health, with a mutual influence. AIM: The aim of this study was to investigate the sexological and psychological correlates of four urogynecological pathologies in a sample of women of childbearing age: overactive pelvic floor, vulvodynia, postcoital cystitis, and interstitial cystitis. Women cured of these conditions were also included, to assess the same aspects after the remission of physical symptoms...
March 21, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38507059/combination-of-urinary-biomarkers-and-machine-learning-models-provided-a-higher-predictive-accuracy-to-predict-long-term-treatment-outcomes-of-patients-with-interstitial-cystitis-bladder-pain-syndrome
#4
JOURNAL ARTICLE
Jia-Fong Jhang, Wan-Ru Yu, Wan-Ting Huang, Hann-Chorng Kuo
PURPOSE: To identify predictive factors for satisfactory treatment outcome of the patients with IC/BPS using urine biomarkers and machine-learning models. METHODS: The IC/BPS patients were prospectively enrolled and provide urine samples. The targeted analytes included inflammatory cytokines, neurotrophins, and oxidative stress biomarkers. The patients with overall subjective symptom improvement of ≥ 50% were considered to have satisfactory results...
March 20, 2024: World Journal of Urology
https://read.qxmd.com/read/38505153/intravesical-instillation-of-platelet-rich-plasma-for-treatment-of-interstitial-cystitis-bladder-pain-syndrome-a-pilot-study
#5
JOURNAL ARTICLE
Ahmed S El Hefnawy, Mohamed Attya Ahmed Hasan, Esam El Sawy, Mohamed Abdel-Razik, Nasr El-Tabey
OBJECTIVE: The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma (PRP) to treat interstitial cystitis/bladder pain syndrome (IC/BPS). MATERIALS AND METHODS: Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH. A pilot study involving 21 female patients with IC/BPS was conducted, and 6 weekly doses of autologous PRP (50 mL) were administered. Patients were followed up at the 2nd, 4th, 8th, and 12th weeks after terminating instillation...
March 2024: Current Urology
https://read.qxmd.com/read/38469652/the-sub-urothelial-durvalumab-injection-1-subdue-1-trial-first-in-human-trial-in-patients-with-bladder-cancer
#6
JOURNAL ARTICLE
Dickon Hayne, Katherine Ong, Nicole Swarbrick, Steve P McCombie, Andrew Moe, Cynthia Hawks, Pravin Viswambaram, Ciara Conduit, Elizabeth Liow, Lisa Spalding, Jayne Lim, Thomas Ferguson, Katie Meehan, Ian D Davis, Andrew D Redfern
OBJECTIVES: To assess the safety of sub-urothelial injection of durvalumab and examine the impact on tissue and circulating immune cell populations. PATIENTS AND METHODS: The patients were chemotherapy and immunotherapy naïve (bacille Calmette-Guérin allowed) with non-metastatic muscle-invasive bladder cancer or non-muscle-invasive bladder cancer planned for radical cystectomy (RC). The study was a Phase Ib 3 + 3 dose-escalation design with sub-urothelial injection of durvalumab at three pre-determined doses (25, 75, 150 mg) diluted in 25 mL normal saline, injected at 25 locations (25 × 1 mL injections), at least 2 weeks before RC...
March 12, 2024: BJU International
https://read.qxmd.com/read/38460003/association-between-chronic-prostatitis-and-the-subsequent-benign-prostatic-hyperplasia-a-population-based-national-cohort-study
#7
JOURNAL ARTICLE
Tsung-Yen Lin, I-Hung Chen, Han-Yu Weng, Yu-Chiao Lin, Chien-Hui Ou, Chung-Yi Li, Yu-Sheng Cheng
PURPOSE: To explore the association between chronic prostatitis (CP) and the subsequent development of benign prostatic hyperplasia (BPH). METHODS: Data analyzed were medical claims of Taiwan's National Health Insurance program. From 2010 to 2017, 3571 patients ≧20 years with CP diagnosed by certified urologists were enrolled. Patients with past BPH diagnosis and diagnosis of prostate cancer, inguinal hernia, interstitial cystitis, and urethritis in the past and within one year after the first CP diagnosis were excluded...
March 9, 2024: World Journal of Urology
https://read.qxmd.com/read/38445489/preliminary-analysis-of-stimulation-parameters-for-sacral-neuromodulation-in-different-indications-a-multi-center-retrospective-cohort-study-from-china
#8
JOURNAL ARTICLE
Lingfeng Meng, Zehao Yan, Xinhao Wang, Yaoguang Zhang, Zhikai Zhu, Wen Zhu, Qing Ling, Xiaoke Sun, Yinjun Gu, Jianwei Lv, Yan Li
BACKGROUND: Sacral neuromodulation (SNM) is an effective approach for treating lower urinary tract dysfunction (LUTD), and stimulation programming is essential for successful treatment. However, research on SNM programming for various indications is limited. Thus, we aimed to determine whether there were differences in the stimulation parameters for different SNM indications and the appropriate programming recommendations. MATERIALS AND METHODS: Clinical data were retrospectively collected from patients with LUTD who underwent SNM and completed internal pulse generator (IPG) implantation...
March 4, 2024: International Journal of Surgery
https://read.qxmd.com/read/38441011/identification-of-plac8-as-a-potential-biomarker-for-the-diagnosis-of-interstitial-cystitis
#9
JOURNAL ARTICLE
Zhilei Zhang, Mingwei Xu, Xiangyan Zhang, Fei Xie, Xiaofei Zhang, Peng Li
BACKGROUND: Interstitial cystitis is a diagnosis of exclusion due to the complexity of its etiology and pathology, which is a chronic disease with an unknown etiology. To our knowledge, few studies were performed to identify predictive biomarkers for interstitial cystitis. OBJECTIVE: This study aimed to identify and validate potential biomarkers for interstitial cystitis (IC). METHODS: The interstitial cystitis datasets were retrieved from the Gene Expression Omnibus (GEO) database...
March 4, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38422486/a-randomized-controlled-pilot-trial-of-telemedicine-delivered-cognitive-behavioral-therapy-tailored-for-interstitial-cystitis-bladder-pain-syndrome
#10
JOURNAL ARTICLE
Lindsey C McKernan, Trey McGonigle, Simon N Vandekar, Leslie J Crofford, David A Williams, Daniel J Clauw, Stephen Bruehl, Blythe A Corbett, Roger R Dmochowski, Elizabeth G Walsh, Anna Grace Kelly, Susanna L Sutherland, Erin L Connors, Anna Ryden, William Stuart Reynolds
No abstract text is available yet for this article.
February 27, 2024: Pain
https://read.qxmd.com/read/38415918/mir-9-enriched-mesenchymal-stem-cells-derived-exosomes-prevent-cystitis-induced-bladder-pain-via-suppressing-tlr4-nlrp3-pathway-in-interstitial-cystitis-mice
#11
JOURNAL ARTICLE
Xiangrong Cui, Xingyu Bi, Xiuping Zhang, Zhiping Zhang, Qin Yan, Yanni Wang, Xia Huang, Xueqing Wu, Xuan Jing, Hongwei Wang
BACKGROUND: Inflammatory response of central nervous system is an important component mechanism in the bladder pain of interstitial cystitis/bladder pain syndrome (IC/BPS). Exosomes transfer with microRNAs (miRNA) from mesenchymal stem cell (MSCs) might inhibit inflammatory injury of the central nervous system. Herein, the purpose of our study was to explore the therapeutic effects by which extracellular vesicles (EVs) derived from miR-9-edreched MSCs in IC/BPS and further investigate the potential mechanism to attenuate neuroinflammation...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38406570/cystoscopic-characteristic-findings-of-interstitial-cystitis-and-clinical-implications
#12
REVIEW
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory bladder disease of unknown etiology, characterized by bladder pain and frequency urgency symptoms. Based on the cystoscopic findings after hydrodistention under anesthesia, the phenotype of IC/BPS includes no glamerulation, characteristic glomerulation, and with Hunner's lesion. IC is specifically defined if there are characteristic Hunner's lesion appeared in cystoscopy or after hydrodistention. If there are glomerulations without Hunner's lesion, BPS should be considered...
2024: Tzu chi medical journal
https://read.qxmd.com/read/38398405/inflammatory-complications-in-chronic-granulomatous-disease
#13
REVIEW
Alexandros Grammatikos, Andrew R Gennery
Chronic granulomatous disease (CGD) is a rare inborn error of immunity that typically manifests with infectious complications. As the name suggest though, inflammatory complications are also common, often affecting the gastrointestinal, respiratory, urinary tracts and other tissues. These can be seen in all various types of CGD, from X-linked and autosomal recessive to X-linked carriers. The pathogenetic mechanisms underlying these complications are not well understood, but are likely multi-factorial and reflect the body's attempt to control infections...
February 15, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397003/the-model-of-interstitial-cystitis-for-evaluating-new-molecular-strategies-of-interstitial-regeneration-in-humans
#14
REVIEW
Elisabetta Mormone, Antonio Cisternino, Lorenzo Capone, Eugenio Caradonna, Andrea Sbarbati
Given the recent evidence in the clinical application of regenerative medicine, mostly on integumentary systems, we focused our interests on recent bladder regeneration approaches based on mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and hyaluronic acid (HA) in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) in humans. IC/BPS is a heterogeneous chronic disease with not-well-understood etiology, characterized by suprapubic pain related to bladder filling and urothelium dysfunction, in which the impairment of immunological processes seems to play an important role...
February 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395078/robotic-simple-cystectomy-as-a-last-resort-for-antibiotic-recalcitrant-recurrent-urinary-tract-infections-in-women
#15
JOURNAL ARTICLE
Caitlin E Carlton, Alana L Christie, Bonnie C Prokesch, Tze-Chen Chao, Maude E Carmel, Gary E Lemack, Ramy Goueli, Vitaly Margulis, Philippe E Zimmern
OBJECTIVES: To report a series of women with antibiotic-recalcitrant recurrent urinary tract infections (rUTI) managed with robotic simple cystectomy and ileal conduit urinary diversion. METHODS: Following Institutional Review Board approval, all female patients who underwent robotic cystectomy for rUTI between 2011-2021 were identified from a prospectively-maintained internal database at a tertiary care center. Exclusion criteria included interstitial cystitis, neurogenic bladder, urinary tract neoplasm, or congenital abnormality...
February 21, 2024: Urology
https://read.qxmd.com/read/38393152/intravesical-botulinum-toxin-injection-plus-hydrodistention-is-more-effective-in-patients-with-bladder-pain-predominant-interstitial-cystitis-bladder-pain-syndrome
#16
JOURNAL ARTICLE
Wan-Ru Yu, Jia-Fong Jhang, Hann-Chorng Kuo
Intravesical botulinum toxin A (BoNT-A) injections are included in the interstitial cystitis/bladder pain syndrome (IC/BPS) treatment guidelines. However, the IC phenotype suitable for treatment with BoNT-A has not been clarified. Therefore, we identified the factors influencing treatment outcomes for intravesical BoNT-A injections in patients with non-Hunner IC/BPS (NHIC). This retrospective study included patients with NHIC who underwent 100 U BoNT-A intravesical injections over the past two decades. Six months after treatment, treatment outcomes were assessed using the Global Response Assessment (GRA)...
February 1, 2024: Toxins
https://read.qxmd.com/read/38391841/quality-of-life-and-treatment-modalities-in-patients-with-interstitial-cystitis-the-patients-perspective
#17
JOURNAL ARTICLE
Charlotte van Ginkel, Frank Martens, Mathilde Scholtes, John Heesakkers, Dick A W Janssen
BACKGROUND: Quality of life (QoL)-based outcomes are hardly incorporated into interstitial cystitis/bladder pain syndrome (IC/BPS) guidelines, because studies are limited and outdated. Therefore, guidelines might not reflect the current clinical situation accurately. Secondly, guidelines suggest using a multimodal approach for BPS/IC management, but data on the patient-perceived efficacy of these therapies are limited. The aim of this study is to investigate the perception of IC/BPS patients of their QoL, to determine which treatments they have received, and to examine how they evaluate the efficacy of these various (alternative) therapies...
February 13, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38381928/understanding-the-sleep-pain-relationship-in-patients-with-interstitial-cystitis-bladder-pain-syndrome
#18
JOURNAL ARTICLE
Alexandra A Kelly, Krista Jones, Olivia Pineau, J Curtis Nickel, Jessica Rose, Robert Moldwin, Christopher Doiron, Claus Riedl, Mauro Cervigni, Jean Wyndaele, Dean A Tripp
INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pelvic pain condition with critical symptoms of urinary urgency and frequency, persistent bladder-related pain, and reduced quality of life. Poor quality sleep can lead to significant disturbances in daily life and increased pain in IC/BPS patients. Resilience, depressive symptoms, and pain catastrophizing have univariate associations with sleep and pain in IC/BPS, suggesting they may be mechanisms in this sleep and pain relationship...
February 15, 2024: Canadian Urological Association Journal
https://read.qxmd.com/read/38381414/pentosan-polysulfate-sodium-causes-diminished-function-and-subtle-morphological-changes-in-retina-and-rpe-of-mice
#19
JOURNAL ARTICLE
Preston E Girardot, Xian Zhang, Nan Zhang, Kevin J Donaldson, Micah A Chrenek, Jana T Sellers, Andrew J Feola, Jack Papania, John M Nickerson, Nieraj Jain, Jeffrey H Boatright
PURPOSE: There are numerous reports of a distinctive maculopathy in adults exposed to pentosan polysulfate sodium (PPS), a drug prescribed to treat bladder discomfort associated with interstitial cystitis. We tested whether PPS treatment of mice injures RPE or retina to provide insight into the etiology of the human condition. METHODS: Mice were fed PPS-supplemented chow over 14 months. RPE and retinal function was assessed by electroretinography (ERG) regularly...
February 1, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38376547/therapeutic-effects-of-af219-on-interstitial-cystitis-bladder-pain-syndrome-induced-by-cyclophosphamide-or-water-avoidance-stress-in-rats
#20
JOURNAL ARTICLE
Ibrahim Erkut Avci, Kerem Teke, Semil Selcen Gocmez, Murat Kasap, Gurler Akpinar, Busra Yaprak Bayrak, Gulsen Celebi, Mehmet Sarihan, Tijen Utkan, Cuneyd Ozkurkcugil
INTRODUCTION AND HYPOTHESIS: To evaluate the effect of AF219, a P2X3 receptor antagonist, in animal models of interstitial cystitis/bladder pain syndrome (IC/BPS) induced by cyclophosphamide (CYP) or water avoidance stress (WAS). METHODS: Thirty-two adult female Wistar albino rats were used in each IC/BPS model. Assessment of nociception and anxiety and severity of inflammation in the bladder were assessed by behavioral experiments and histopathological examinations respectively...
February 20, 2024: International Urogynecology Journal
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