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Interstitial Cystitis

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https://www.readbyqxmd.com/read/29137981/umbilical-cord-derived-mesenchymal-stem-cells-alleviated-inflammation-and-inhibited-apoptosis-in-interstitial-cystitis-via-akt-mtor-signaling-pathway
#1
Juncong Xie, Bolong Liu, Jialiang Chen, Yuancheng Xu, Hailun Zhan, Fei Yang, Wenbiao Li, Xiangfu Zhou
Interstitial cystitis (IC) is a bladder syndrome characterized by pelvic pain and urinary frequency without infection or other identifiable pathology. There are no effective treatments to cure IC. This study investigated the effects of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection on IC rat model. Furthermore, we used a coculture system to find the possible molecular mechanism on the human uroepithelial cells (SV-HUC-1), which was the cell model of IC. A rat model of IC was established via systemic injection with cyclophosphamide (CYP) and a cell model of IC was induced by being exposed to tumor necrosis factor (TNF)-α (10 ng/ml)...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29132932/apoptotic-effect-as-biomarker-of-disease-severity-and-follow-up-in-interstitial-cystitis
#2
C Di Capua-Sacoto, A Sanchez-Llopis, J E Oconnor, A Martinez-Romero, J L Ruiz-Cerdá
OBJECTIVE: To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis. MATERIAL AND METHODS: A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynaecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analysed...
November 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29118019/acyloxyacyl-hydrolase-modulates-pelvic-pain-severity
#3
Wenbin Yang, Ryan E Yaggie, Mingchen C Jiang, Charles N Rudick, Joseph D Done, Charles J Heckman, John M Rosen, Anthony J Schaeffer, David J Klumpp
Chronic pelvic pain causes significant patient morbidity and is a bane to clinicians. Using a murine neurogenic cystitis model that recapitulates key aspects of interstitial cystitis/bladder pain syndrome (IC), we recently showed that pseudorabies virus (PRV) induces severe pelvic allodynia in BALB/c mice, relative to C57BL/6 mice. Here, we report that a quantitative trait locus (QTL) analysis of PRV-induced allodynia in F2CxB progeny identified a polymorphism on chromosome 13, rs6314295, significantly associated with allodynia (LOD=3...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29106051/treatment-of-chronic-refractory-neuropathic-pelvic-pain-with-high-frequency-10-kilohertz-spinal-cord-stimulation
#4
Thomas Simopoulos, Jason Yong, Jatinder S Gill
Chronic non-malignant pain perceived in the pelvic region commonly presents as a diagnostic challenge and is often difficult to manage. Treatment options are delayed as well as limited. The prevalence in the United States and the United Kingdom has been estimated to range from 14.7 % to 24% respectively (1, 2). Common chronic pelvic pain syndromes include interstitial cystitis, chronic prostatitis, coccygodynia, vulvodynia, chronic proctalgia, and pudendal neuralgia. This article is protected by copyright. All rights reserved...
November 6, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29065222/digital-quantitative-analysis-of-mast-cell-infiltration-in-interstitial-cystitis
#5
Yoshiyuki Akiyama, Daichi Maeda, Teppei Morikawa, Aya Niimi, Akira Nomiya, Yukio Yamada, Yasuhiko Igawa, Akiteru Goto, Masashi Fukayama, Yukio Homma
AIMS: To evaluate the significance of mast cell infiltration in interstitial cystitis (IC) by comparison with equally inflamed controls using a digital quantification technique. METHODS: Bladder biopsy specimens from 31 patients with Hunner type IC and 38 patients with non-Hunner type IC were analyzed. Bladder biopsy specimens from 37 patients without IC, including 19 non-specific chronic cystitis ("non-IC cystitis") specimens and 18 non-inflamed bladder ("normal bladder") specimens, were used as controls...
October 24, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29057994/effects-of-herpes-simplex-virus-vectors-encoding-poreless-trpv1-or-protein-phosphatase-1%C3%AE-in-a-rat-cystitis-model-induced-by-hydrogen-peroxide
#6
S Takai, T Majima, B Reinhart, W F Goins, Y Funahashi, M Gotoh, P Tyagi, J C Glorioso, N Yoshimura
Enhanced afferent excitability is considered to be an important pathophysiological basis of interstitial cystitis/bladder pain syndrome (IC/BPS). In addition, transient receptor potential vanilloid-1 (TRPV1) receptors are known to be involved in afferent sensitization. Animals with hydrogen peroxide (HP)-induced cystitis have been used as a model exhibiting pathologic characteristics of chronic inflammatory condition of the bladder. This study investigated the effect of gene therapy with replication-defective herpes simplex virus (HSV) vectors encoding poreless TRPV1 (PL) or protein phosphatase 1 α (PP1α), a negative regulator of TRPV1, using a HP-induced rat model of cystitis...
October 20, 2017: Gene Therapy
https://www.readbyqxmd.com/read/29048741/diagnostic-value-of-urinary-cxcl10-as-a-biomarker-for-predicting-hunner-type-interstitial-cystitis
#7
Aya Niimi, Yasuhiko Igawa, Naoki Aizawa, Toshiki Honma, Akira Nomiya, Yoshiyuki Akiyama, Jun Kamei, Tetsuya Fujimura, Hiroshi Fukuhara, Yukio Homma
AIM: To investigate the feasibility of chemokines and cytokines potentially elevated in the bladder tissue of Hunner type interstitial cystitis (HIC) as urinary markers for distinguishing HIC from non-Hunner type interstitial cystitis (NHIC) METHODS: Urine specimens were collected from 41 HIC patients, 25 NHIC patients, and 31 healthy volunteers (control). The supernatants of urine specimens were subjected to ELISA kits for measurements of 10 cytokines and chemokines, whose gene expression was known to be elevated in HIC bladder tissue...
October 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29044760/development-of-novel-and-non-invasive-diagnostic-markers-for-lower-urinary-tract-symptoms-using-urothelial-cells-in-voided-urine
#8
Hiroshi Shimura, Takahiko Mitsui, Sachiko Tsuchiya, Tatsuya Miyamoto, Tatsuya Ihara, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuki Imai, Takanori Mochizuki, Masayuki Takeda
OBJECTIVES: We evaluated the association between lower urinary tract symptoms (LUTS) and the expression of connexin (Cx) and transient receptor potential (TRP) channel on urothelial cells non-invasively collected from voided urine in humans. METHODS: A total of 55 patients (36 males and 19 females, median age: 71 years old), who were followed up at University of Yamanashi Hospital, were enrolled in the present study. Urothelial cells were collected from voided urine of patients, and the mRNA expression of each subtype of Cxs and TRP channels was measured using quantitive real-time reverse transcription polymerase chain reaction...
October 17, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29034266/bladder-pain-in-an-ll-37-interstitial-cystitis-and-painful-bladder-syndrome-model
#9
Wanjian Jia, Austin J Schults, Mark Martin Jensen, Xiangyang Ye, Jeremiah A Alt, Glenn D Prestwich, Siam Oottamasathien
Our goal was to evaluate the pain response in an LL-37 induced murine model for interstitial cystitis/painful bladder syndrome (IC/PBS). In particular, we sought to characterize the dose dependence, time-course, and relationship of LL-37 induced bladder inflammation and pain. The IC/PBS model was induced in C57Bl/6 mice by instilling 50 μL of LL-37, an immunomodulatory human cathelicidin (anti-microbial peptide), in the bladder for 1 hr. Pain responses were measured using von Frey filaments (0.04 gm to 4.0 gm) before and after LL-37 instillation...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29031769/intra-trigonal-onabotulinum-toxin-a-improves-bladder-symptoms-and-quality-of-life-in-bladder-pain-syndrome-interstitial-cystitis-patients-a-pilot-single-centre-randomized-double-blind-placebo-controlled-trial
#10
R Pinto, D Costa, A Morgado, P Pereira, A Charrua, J Silva, F Cruz
PURPOSE: To compare efficacy and safety of trigonal injections of onabotulinumtoxinA and saline in Bladder Pain Syndrome/Interstitial Cystitis patients. MATERIALS AND METHODS: This phase II study enrolled women with Bladder Pain Syndrome/Interstitial Cystitis >6months and pain ≥4 in 0-10 visual analogue scale, refractory to common treatment. OnabotulinumtoxinA 100U (n=10) or saline (placebo, n=9), were administered as 10 trigonal injections of 1ml. Primary end-point was change from baseline in pain intensity reported at week 12...
October 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29025381/adenovirus-infection-as-a-cause-of-fever-of-unknown-origin-and-allograft-dysfunction-in-a-kidney-transplant-recipient
#11
Michelle Saliba, Hala Kfoury Assouf, Souodod Abbas, Pierre Abi Hanna, Gaby Kamel, Antoine Barbari
With the recent introduction of more potent modern immunosuppressive regimens in solid-organ transplant, new types of viral infections such as adenovirus are emerging as a potential cause for graft dysfunction and loss. We report a case of 41-year-old male patient with end-stage renal disease from recurrent kidney stones who underwent kidney transplant from a deceased 12-year-old female donor. He developed adenoviral infection with acute cystitis, microscopic hematuria, and necrotizing interstitial nephritis associated with graft dysfunction within the first month of the postoperative period...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28990698/psychosocial-co-morbidities-in-interstitial-cystitis-bladder-pain-syndrome-ic-bps-a-systematic-review
#12
REVIEW
Lindsey C McKernan, Colin G Walsh, William S Reynolds, Leslie J Crofford, Roger R Dmochowski, David A Williams
AIMS: Psychosocial factors amplify symptoms of Interstitial Cystitis (IC/BPS). While psychosocial self-management is efficacious in other pain conditions, its impact on an IC/BPS population has rarely been studied. The objective of this review is to learn the prevalence and impact of psychosocial factors on IC/BPS, assess baseline psychosocial characteristics, and offer recommendations for assessment and treatment. METHOD: Following PRISMA guidelines, primary information sources were PubMed including MEDLINE, Embase, CINAHL, and GoogleScholar...
October 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28983523/glycoamino-acid-analogues-of-the-thomsen-friedenreich-tumor-associated-carbohydrate-antigen-synthesis-and-evaluation-of-novel-antiproliferative-factor-glycopeptides
#13
Maqbool A Siddiqui, Shailesh Ambre, Susan K Keay, Jeffrey M Rhyne, Chen-Ou Zhang, Joseph J Barchi
Glycoamino acid analogues of the Thomsen-Friedenreich antigen disaccharide, where the 4' and 4″ hydroxyl groups were substituted with fluorine or hydrogen, were synthesized and incorporated into the asialylated antiproliferative factor (as-APF), a biologically active form of APF, a glycopeptide found in the urine of patients with interstitial cystitis. Various strategies were employed to incorporate the fluorine atom at the 4-positions of either the galactose or N-acetylgalactosamine unit of the disaccharide antigen, based on stereochemistry and reactivity...
September 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28967359/the-role-of-centralised-pain-in-osteoarthritis
#14
REVIEW
Daniel J Clauw, Afton L Hassett
The mechanisms underlying chronic pain states, including osteoarthritis, differ from those underlying acute pain. In chronic pain states, central nervous system (CNS) factors often play a particularly prominent role. In many individuals with chronic pain, pain can occur with minimal or no evidence of ongoing nociceptive input. Medical subspecialties have applied a wide-range of labels to these pain conditions including fibromyalgia, irritable bowel syndrome and interstitial cystitis to name just a few. These same CNS processes can augment or magnify pain when there is ongoing nociceptive input, as in conditions such as osteoarthritis or autoimmune disorders...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28954463/comparison-of-5-different-rat-models-to-establish-a-standard-animal-model-for-research-into-interstitial-cystitis
#15
Phil Hyun Song, So Young Chun, Jae-Wook Chung, Yeon Yong Kim, Hyo Jung Lee, Jun Nyung Lee, Yun-Sok Ha, Eun Sang Yoo, Tae Gyun Kwon, Jeongshik Kim, Dae Hwan Kim, Bum Soo Kim
PURPOSE: We evaluated 5 different rat models using different agents in order to establish a standard animal model for interstitial cystitis (IC) in terms of the functional and pathologic characteristics of the bladder. METHODS: Five IC models were generated in 8-week-old female Sprague-Dawley rats via transurethral instillation of 0.1M hydrogen chloride (HCl) or 3% acetic acid (AA), intraperitoneal injection of cyclophosphamide (CYP) or lipopolysaccharide (LPS), or subcutaneous injection of uroplakin II (UPK2)...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28934076/delayed-urinary-symptoms-induced-by-ketamine
#16
María Robles-Martínez, Alfonso C Abad, Violeta Pérez-Rodríguez, Elena Ros-Cucurull, Abderraman Esojo, Carlos Roncero
One of the side-effects of ketamine abuse is genito-urinary damage. This report describes a case of a former ketamine user who presented with urinary symptoms associated with ketamine years after stopping consumption. This was a 26-year-old male with a history of ketamine abuse. He started treatment for alcohol dependence at age 19. He smoked marijuana daily and denied any other drug use. During the follow-up, urinary symptoms were evidenced (dysuria, frequency, urgency, incontinence, nocturia, hematuria, and suprapubic pain)...
September 21, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28912620/hormonal-contraception-and-the-development-of-autoimmunity-a-review-of-the-literature
#17
William V Williams
Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Based on this review, substantial evidence exists linking the use of combined oral contraceptives to a lower incidence of hyperthyroidism, an increase in multiple sclerosis, ulcerative colitis, Crohn's disease, Systemic Lupus Erythematosus, and interstitial cystitis...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28893174/antiproliferative-factor-apf-binds-specifically-to-sites-within-the-cytoskeleton-associated-protein-4-ckap4-extracellular-domain
#18
Burzin Chavda, Jun Ling, Thomas Majernick, Sonia Lobo Planey
BACKGROUND: Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis-a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelial cells and cancer cells in vitro, presumably by binding to its cellular receptor, cytoskeleton associated-protein 4 (CKAP4); however, the biophysical interaction of APF with CKAP4 has not been characterized previously. In this study, we used surface plasmon resonance (SPR) to explore the binding kinetics of the interaction of APF and as-APF (a desialylated APF analogue with full activity) to CKAP4...
September 11, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28887515/sacral-neuromodulation-for-refractory-bladder-pain-syndrome-interstitial-cystitis-a-global-systematic-review-and-meta-analysis
#19
Junpeng Wang, Yang Chen, Jiawei Chen, Guihao Zhang, Peng Wu
Bladder pain syndrome/interstitial cystitis (BPS/IC) is a common debilitating disease and there has not been consistently effective treatment. We aimed to evaluate all available literature regarding the efficacy and safety of sacral neuromodulation (SNM) for refractory BPS/IC. A comprehensive search of Pubmed, Web of Science and Cochrane Library through May 2016 was conducted. A total of 17 studies enrolling 583 patients were identified. Pooled analyses demonstrated that SNM was associated with great reduction in pelvic pain (weighted mean difference [WMD] -3...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886046/effects-of-water-avoidance-stress-on-peripheral-and-central-responses-during-bladder-filling-in-the-rat-a-multidisciplinary-approach-to-the-study-of-urologic-chronic-pelvic-pain-syndrome-mapp-research-network-study
#20
Zhuo Wang, Harriet H Chang, Yunliang Gao, Rong Zhang, Yumei Guo, Daniel P Holschneider, Larissa V Rodriguez
Stress plays a role in the exacerbation and possibly the development of functional lower urinary tract disorders. Chronic water avoidance stress (WAS) in rodents is a model with high construct and face validity to bladder hypersensitive syndromes, such as interstitial cystitis/bladder pain syndrome (IC/BPS), characterized by urinary frequency and bladder hyperalgesia and heightened stress responsiveness. Given the overlap of the brain circuits involved in stress, anxiety, and micturition, we evaluated the effects chronic stress has on bladder function, as well as its effects on regional brain activation during bladder filling...
2017: PloS One
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