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Interstitial Cystitis

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https://www.readbyqxmd.com/read/29341502/advances-in-intravesical-therapy-for-bladder-pain-syndrome-bps-interstitial-cystitis-ic
#1
REVIEW
En Meng, Yu-Chao Hsu, Yao-Chi Chuang
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life. The etiology of IC/BPS remains unclear, and its cause may be multifactorial. Diagnosis of IC/BPS is based on clinical features, and the possibility of other conditions must be ruled out first. Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used for IC/BPS, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT-A)...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29336927/efficacy-and-safety-of-sacral-and-percutaneous-tibial-neuromodulation-in-non-neurogenic-lower-urinary-tract-dysfunction-and-chronic-pelvic-pain-a-systematic-review-of-the-literature
#2
REVIEW
Manuela Tutolo, Enrico Ammirati, John Heesakkers, Thomas M Kessler, Kenneth M Peters, Tina Rashid, Karl-Dietrich Sievert, Michele Spinelli, Giacomo Novara, Frank Van der Aa, Dirk De Ridder
CONTEXT: Neuromodulation is considered in patients with non-neurogenic lower urinary tract dysfunction (LUTD) not responsive to conservative treatment. OBJECTIVE: To systematically review the available studies on efficacy and safety of sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) in non-neurogenic LUTDs not responsive to conservative treatments. EVIDENCE ACQUISITION: A literature research was conducted in PubMed/Medline and Scopus, restricted to articles in English, published between January 1998 and June 2017, with at least 20 patients and 6 mo of follow-up...
January 11, 2018: European Urology
https://www.readbyqxmd.com/read/29331031/comparative-study-of-efficacy-and-safety-between-bladder-body-and-trigonal-intravesical-onabotulinumtoxina-injection-in-the-treatment-of-interstitial-cystitis-refractory-to-conventional-treatment-a-prospective-randomized-clinical-trial
#3
Yuan-Hong Jiang, Jia-Fong Jhang, Cheng-Ling Lee, Hann-Chorng Kuo
PURPOSE: Intravesical onabotulinumtoxinA (BoNT-A) injection can relieve symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS). However, the therapeutic efficacy of different injection sites is not well known. This study compared therapeutic efficacy and safety between bladder body and trigonal BoNT-A injection. MATERIALS AND METHODS: Patients were randomly treated with 100U of BoNT-A in 10 mL saline injected into 20 bladder body sites or 10 trigonal sites...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#4
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29315774/extent-of-hunner-lesions-the-relationships-with-symptom-severity-and-clinical-parameters-in-hunner-type-interstitial-cystitis-patients
#5
Yoshiyuki Akiyama, Aya Niimi, Akira Nomiya, Yukio Yamada, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
AIMS: To assess the clinical impact of Hunner lesions in patients with Hunner type interstitial cystitis (HIC). METHODS: The clinical records of 94 HIC patients who underwent their first hydrodistension (with lesion fulguration) were retrospectively reviewed. At surgery, the extent of each lesion was classified in terms of the relative involvement for the whole-bladder luminal surface; we defined four grades of involvement: <10%, 10-24%, 25-49%, and ≥50%; and two grades of severity: <25% (focal) and ≥25% (extensive)...
January 9, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29307733/safety-and-feasibility-of-intravesical-instillation-of-botulinum-toxin-a-in-hydrogel-based-slow-release-delivery-system-in-interstitial-cystitis-bladder-pain-syndrome-patients-a-pilot-study
#6
Yishai H Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok, Kobi Stav
OBJECTIVE: To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours. METHODS: A single intravesical instillation of 200U BTX-A premixed with 40ml TC-3 Gel was delivered to the bladder...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29299202/the-role-of-tsg-6-and-uroplakin-iii-in-bladder-pain-syndrome-interstitial-cystitis-in-rats-and-humans
#7
Yi-Song Lv, Rui Gao, Qing-Ming Lin, Tao Jiang, Qin Chen, Song-Xi Tang, Hou-Ping Mao, Hui-Liang Zhou, Lin-Sheng Cao
Objectives: We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods: Expression of TSG-6 and uroplakin III was determined by immuno- histochemistry of bladder biopsy samples from control human subjects and patients with verified BPS/IC...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29298474/current-pharmacologic-approaches-in-painful-bladder-research-an-update
#8
REVIEW
Karl-Erik Andersson, Lori Birder
The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest success. A contributing factor to the low efficacy is the lack of phenotyping the patients. Individualized treatment based on is desirable, but further phenotype categorization is needed...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29297205/cyclophosphamide-for-connective-tissue-disease-associated-interstitial-lung-disease
#9
REVIEW
Hayley Barnes, Anne E Holland, Glen P Westall, Nicole Sl Goh, Ian N Glaspole
BACKGROUND: Approximately one-third of individuals with interstitial lung disease (ILD) have associated connective tissue disease (CTD). The connective tissue disorders most commonly associated with ILD include scleroderma/systemic sclerosis (SSc), rheumatoid arthritis, polymyositis/dermatomyositis, and Sjögren's syndrome. Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of life, and death...
January 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29288643/a-case-crossover-study-of-urologic-chronic-pelvic-pain-syndrome-flare-triggers-in-the-mapp-research-network
#10
Siobhan Sutcliffe, Thomas Jemielita, H Henry Lai, Gerald L Andriole, Catherine S Bradley, J Quentin Clemens, Robert Gallop, Thomas M Hooton, Karl J Kreder, John N Krieger, John W Kusek, Jennifer Labus, M Scott Lucia, Sean Mackey, Bruce D Naliboff, Nancy A Robinson, Larissa V Rodriguez, Alisa Stephens-Shields, Adrie van Bokhoven, Kathleen Y Wolin, Yan Yan, Claire C Yang, J Richard Landis, Graham A Colditz
PURPOSE: Although many factors have been proposed to trigger symptom exacerbations ("flares") in patients with interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, few studies have investigated these factors empirically. Therefore, we embedded a case-crossover study in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain longitudinal study to evaluate a range of patient-reported triggers. MATERIALS AND METHODS: Exposure to proposed triggers (diet, physical activities, sedentary behaviors, stress, sexual activities, infection-like symptoms, and allergies) was assessed by questionnaire a maximum of three times when participants reported flares and at three randomly-selected times...
December 27, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29283084/mirabegron-as-adjuvant-treatment-for-patients-with-interstitial-cystitis-bladder-pain-syndrome
#11
Michael Di Lena, Victoria Tolls, Kerri-Lynn Kelly, J Curtis Nickel
INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) patients represent a heterogeneous group with pain and urinary storage symptoms and varying responses to current treatment options. The novel beta-3 agonist, mirabegron, has been shown to improve storage symptoms of patients with bladder overactivity; however, its effect on symptoms in the IC/BPS population has yet to be studied. METHODS: Patients diagnosed at a single IC centre with IC/BPS undergoing standard therapy were treated with additional daily mirabegron 25 mg and seen in followup post-treatment...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29278234/diagnostic-and-treatment-guidelines-for-gastrointestinal-and-genitourinary-endometriosis
#12
Stacy Young, Megan Kennedy Burns, Lucia DiFrancesco, Azadeh Nezhat, Camran Nezhat
Endometriosis is commonly misdiagnosed, even among many experienced gynecologists. Gastrointestinal and genitourinary endometriosis is particularly difficult to diagnose, and is commonly mistaken for other pathologies, such as irritable bowel syndrome, interstitial cystitis, and even psychological disturbances. This leads to delays in diagnosis, mismanagement, and unnecessary testing. In this review, we will discuss the diagnosis and management of genitourinary and gastrointestinal endometriosis. Medical management may be tried first, but often fails in cases of urinary tract endometriosis...
December 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29277923/expression-of-programmed-death-ligand-1-on-bladder-tissues-is-detected-in-a-clinically-and-histologically-well-defined-interstitial-cystitis-cohort
#13
Yuke Chen, Wei Yu, Yang Yang, Yunxiang Xiao, Yun Cui, Jihong Duan, Qun He, Jie Jin, Shiliang Wu
OBJECTIVE: To investigate the expression of programmed death ligand-1 (PD-L1) in interstitial cystitis (IC). METHODS: We reviewed the data of IC patients underwent hydrodistension plus bladder biopsy. Follow-ups were performed. We assessed the degree of inflammation of the bladder wall on slides stained with hematoxylin and eosin (H&E). We performed immunohistochemistry for PD-L1 expression detection and for counting T lymphocytes and B lymphocytes. RESULTS: The present study included eight men and 32 women...
December 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29249972/pathophysiological-role-of-transient-receptor-potential-ankyrin-1-in-a-mouse-long-lasting-cystitis-model-induced-by-an-intravesical-injection-of-hydrogen-peroxide
#14
Shohei Oyama, Koji Dogishi, Mizuki Kodera, Masashi Kakae, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Chronic inflammatory bladder disorders, such as interstitial cystitis/bladder pain syndrome, are associated with poor quality of life. The exact pathological processes remain unclear, but accumulating evidence suggests that reactive oxidative species (ROS) are involved in urinary bladder disorders. Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model. However, the roles of TRPA1 in chronic inflammatory bladder are not fully understood...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29241263/systematic-review-of-oral-therapy-for-the-treatment-of-symptoms-of-bladder-pain-syndrome-the-brazilian-guidelines
#15
Thaís Guimarães Dos Santos, Isabela Albuquerque Severo de Miranda, Christiana Campani Nygaard, Lucas Schreiner, Rodrigo de Aquino Castro, Jorge Milhen Haddad
Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease that mainly affects women. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture, with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as "an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes...
December 14, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29240250/microrna-139-5p-inhibits-epithelial-mesenchymal-transition-and-fibrosis-in-post-menopausal-women-with-interstitial-cystitis-by-targeting-lpar4-via-the-pi3k-akt-signaling-pathway
#16
Chen Jiang, Zhen Tong, Wei-Lin Fang, Qi-Bo Fu, Yin-Jun Gu, Ting-Ting Lv, Dong-Ming Liu, Wei Xue, Jian-Wei Lv
The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed by HE, Masson and Picrosirius red staining. LPAR4 positive expression rate were determined by IHC. ELISA was performed to detect the levels of IL-6, IL-8, IL-10 and TNF-α. Rat IC models were randomized into seven different groups...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29232035/therapeutic-effects-of-endoscopic-ablation-in-hunner-type-interstitial-cystitis-patients
#17
Kwang Jin Ko, Hyunwoo Chung, Yoon Seok Suh, Sin Woo Lee, Tae Heon Kim, Kyu-Sung Lee
OBJECTIVES: To investigate the efficacy of endoscopic ablation of Hunner lesions (HLs) in patients with interstitial cystitis (IC) and to find predictors of early recurrence of HLs. MATERIALS AND METHODS: A prospective study was performed for Hunner type IC who underwent transurethral ablation. We repeated endoscopic ablation when symptoms and HLs recurred during the follow-up period. The primary endpoint was recurrence-free time. Secondary endpoints were a change of number of frequency, nocturia, and urgency episodes and changes in visual analogue scale for pain and other symptom indices at follow-up visits...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29225061/crowdsourcing-disease-biomarker-discovery-research-the-ip4ic-study
#18
Michael B Chancellor, Sarah N Bartolone, Andrew Veerecke, Laura E Lamb
PURPOSE: Biomarker discovery is limited by readily assessable, cost efficient, human samples available in large numbers that represent the entire heterogeneity of the disease. We developed a novel active participation crowdsourcing method to develop a Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines to discriminate Interstitial cystitis/bladder pain syndrome (IC/BPS) with Hunner's lesion (UIC) patients from controls and IC patients without Hunner's lesions...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29223727/urodynamic-characteristics-might-be-variable-in-bladder-pain-syndrome-interstitial-cystitis-patients-with-different-non-bladder-co-morbid-conditions
#19
Wei-Ming Cheng, Yu-Hua Fan, Alex T L Lin
BACKGROUND: The aim of the study was to identify the impact of non-bladder co-morbid conditions on the urodynamic characteristics of patients with bladder pain syndrome/interstitial cystitis. METHODS: Patients with bladder pain syndrome/interstitial cystitis completed the screening questionnaires for chronic fatigue syndrome, irritable bowel syndrome, fibromyalgia, temporo-mandibular disorders, multiple chemical sensitivities, tension/migraine headache, and localized myofascial pain disorder...
December 6, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29173267/treatment-effectiveness-in-interstitial-cystitis-bladder-pain-syndrome-do-patient-perceptions-align-with-efficacy-based-guidelines
#20
Avril Lusty, Elizabeth Kavaler, Kay Zakariasen, Victoria Tolls, J Curtis Nickel
INTRODUCTION: We sought to determine if patients' perceptions of success or failure of interstitial cystitis/bladder pain syndrome (IC/BPS) therapies proposed in treatment guidelines align with the evidence from available clinical trial treatment data. METHODS: A total of 1628 adult females with a self-reported diagnosis of IC completed a web-based survey in which patients described their perceived outcomes with the therapies they were exposed to. Previously published literature used in part to develop IC/BPS guidelines provided the clinical trial data outcomes...
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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