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https://www.readbyqxmd.com/read/27910820/4d-bioprinting-the-next-generation-technology-for-biofabrication-enabled-by-stimuli-responsive-materials
#1
Yi-Chen Li, Yu Shrike Zhang, Ali Akpek, Su Ryon Shin, Ali Khademhosseini
Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, 4D bioprinting aims to create dynamic 3D patterned biological structures that can transform their shapes or behavior under various stimuli. In this review, we highlight the potential use of various stimuli-responsive materials for 4D printing and their extension into biofabrication...
December 2, 2016: Biofabrication
https://www.readbyqxmd.com/read/27898010/applications-of-alginate-based-bioinks-in-3d-bioprinting
#2
REVIEW
Eneko Axpe, Michelle L Oyen
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27862956/high-throughput-fabrication-and-modular-assembly-of-3d-heterogeneous-microscale-tissues
#3
Wenguang Yang, Haibo Yu, Gongxin Li, Yuechao Wang, Lianqing Liu
3D hydrogel microstructures that encapsulate cells have been used in broad applications in microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances in microstructure assembly, such as bioprinting, magnetic assembly, microfluidics, and acoustics, have enabled the construction of designed 3D tissue structures with spatially organized cells in vitro. However, a bottleneck exists that still hampers the application of microtissue structures, due to a lack of techniques that combined high-throughput fabrication and flexible assembly...
November 11, 2016: Small
https://www.readbyqxmd.com/read/27819188/feasibility-of-3-d-bioprinting-with-a-modified-desktop-3d-desktop-printer
#4
Todd Goldstein, Lee P Smith, Alex Krush, Kevin Mercadante, Dan Lagalante, Casey Epstein, John A Schwartz, David Zeltsman, Daniel Anthony Grande
Numerous studies have shown the capabilities of 3D printing for use in the medical industry. At the time of this publication, basic home desktop 3-D printer kits can cost as little as $300, while medical-specific 3D bioprinters can cost upwards of $300,000. The purpose of this study was to show how a commercially available desktop 3D printer could be modified to bioprint an engineered poly-L-lactic acid (PLLA) scaffold containing viable chondrocytes in a bioink. Our bioprinter was used to create a living 3D functional tissue-engineered cartilage scaffold...
November 7, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27818910/biologically-inspired-smart-release-system-based-on-3d-bioprinted-perfused-scaffold-for-vascularized-tissue-regeneration
#5
Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang
A critical challenge to the development of large-scale artificial tissue grafts for defect reconstruction is vascularization of the tissue construct. As an emerging tissue/organ manufacturing technique, 3D bioprinting offers great precision in controlling the internal architecture of a scaffold with preferable mechanical strength and printing complicated microstructures comparable to native tissue. However, current bioprinting techniques still exhibit difficulty in achieving biomimetic nano resolution and cooperating with bioactive spatiotemporal signals...
August 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27786234/applications-of-3d-printing-in-cardiovascular-diseases
#6
REVIEW
Andreas A Giannopoulos, Dimitris Mitsouras, Shi-Joon Yoo, Peter P Liu, Yiannis S Chatzizisis, Frank J Rybicki
3D-printed models fabricated from CT, MRI, or echocardiography data provide the advantage of haptic feedback, direct manipulation, and enhanced understanding of cardiovascular anatomy and underlying pathologies. Reported applications of cardiovascular 3D printing span from diagnostic assistance and optimization of management algorithms in complex cardiovascular diseases, to planning and simulating surgical and interventional procedures. The technology has been used in practically the entire range of structural, valvular, and congenital heart diseases, and the added-value of 3D printing is established...
October 27, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27785150/applications-of-3d-printing-in-healthcare
#7
Helena Dodziuk
3D printing is a relatively new, rapidly expanding method of manufacturing that found numerous applications in healthcare, automotive, aerospace and defense industries and in many other areas. In this review, applications in medicine that are revolutionizing the way surgeries are carried out, disrupting prosthesis and implant markets as well as dentistry will be presented. The relatively new field of bioprinting, that is printing with cells, will also be briefly discussed.
September 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/27770218/3d-cell-culturing-and-possibilities-for-myometrial-tissue-engineering
#8
Minoo Heidari Kani, Eng-Cheng Chan, Roger C Young, Trent Butler, Roger Smith, Jonathan W Paul
Research insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. The use of traditional culturing methods limits the exploration of complex uterine functions, such as cell interactions, connectivity and contractile behaviour, as it fails to mimic the three-dimensional (3D) nature of uterine cell interactions in vivo. Animal models are an option, however, use of these models is constrained by ethical considerations as well as translational limitations to humans...
October 21, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27767258/design-and-printing-strategies-in-3d-bioprinting-of-cell-hydrogels-a-review
#9
Jia Min Lee, Wai Yee Yeong
Bioprinting is an emerging technology that allows the assembling of both living and non-living biological materials into an ideal complex layout for further tissue maturation. Bioprinting aims to produce engineered tissue or organ in a mechanized, organized, and optimized manner. Various biomaterials and techniques have been utilized to bioprint biological constructs in different shapes, sizes and resolutions. There is a need to systematically discuss and analyze the reported strategies employed to fabricate these constructs...
October 21, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27766838/3d-bioprinting-a-cell-laden-bone-matrix-for-breast-cancer-metastasis-study
#10
Xuan Zhou, Wei Zhu, Margaret Nowicki, Shida Miao, Haitao Cui, Benjamin Holmes, Robert I Glazer, Lijie Grace Zhang
Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts and human bone marrow mesenchymal stem cells (MSCs)). A tabletop stereolithography 3D bioprinter was employed to fabricate a series of bone matrices consisting of osteoblasts or MSCs encapsulated in gelatin methacrylate (GelMA) hydrogel with nanocrystalline hydroxyapatite (nHA)...
October 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27733321/human-hepatocytes-loaded-in-3d-bioprinting-generate-mini-liver
#11
Cheng Zhong, Hai-Yang Xie, Lin Zhou, Xiao Xu, Shu-Sen Zheng
BACKGROUND: Because of an increasing discrepancy between the number of potential liver graft recipients and the number of organs available, scientists are trying to create artificial liver to mimic normal liver function and therefore, to support the patient's liver when in dysfunction. 3D printing technique meets this purpose. The present study was to test the feasibility of 3D hydrogel scaffolds for liver engineering. METHODS: We fabricated 3D hydrogel scaffolds with a bioprinter...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27725720/bioprinting-of-3d-convoluted-renal-proximal-tubules-on-perfusable-chips
#12
Kimberly A Homan, David B Kolesky, Mark A Skylar-Scott, Jessica Herrmann, Humphrey Obuobi, Annie Moisan, Jennifer A Lewis
Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within an extracellular matrix and housed in perfusable tissue chips, allowing them to be maintained for greater than two months. Their convoluted tubular architecture is circumscribed by proximal tubule epithelial cells and actively perfused through the open lumen...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725343/3d-bioprinted-glioma-stem-cells-for-brain-tumor-model-and-applications-of-drug-susceptibility
#13
Xingliang Dai, Cheng Ma, Qing Lan, Tao Xu
Glioma is still difficult to treat because of its high malignancy, high recurrence rate, and high resistance to anticancer drugs. An alternative method for research of gliomagenesis and drug resistance is to use in vitro tumor model that closely mimics the in vivo tumor microenvironment. In this study, we established a 3D bioprinted glioma stem cell model, using modified porous gelatin/alginate/fibrinogen hydrogel that mimics the extracellular matrix. Glioma stem cells achieved a survival rate of 86.92%, and proliferated with high cellular activity immediately following bioprinting...
October 11, 2016: Biofabrication
https://www.readbyqxmd.com/read/27722710/bioprinted-thrombosis-on-a-chip
#14
Yu Shrike Zhang, Farideh Davoudi, Philipp Walch, Amir Manbachi, Xuan Luo, Valeria Dell'Erba, Amir K Miri, Hassan Albadawi, Andrea Arneri, Xiaoyun Li, Xiaoying Wang, Mehmet Remzi Dokmeci, Ali Khademhosseini, Rahmi Oklu
Pathologic thrombosis kills more people than cancer and trauma combined; it is associated with significant disability and morbidity, and represents a major healthcare burden. Despite advancements in medical therapies and imaging, there is often incomplete resolution of the thrombus. The residual thrombus can undergo fibrotic changes over time through infiltration of fibroblasts from the surrounding tissues and eventually transform into a permanent clot often associated with post-thrombotic syndrome. In order to understand the importance of cellular interactions and the impact of potential therapeutics to treat thrombosis, an in vitro platform using human cells and blood components would be beneficial...
October 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27716641/a-versatile-method-for-combining-different-biopolymers-in-a-core-shell-fashion-by-3d-plotting-to-achieve-mechanically-robust-constructs
#15
Ashwini Rahul Akkineni, Tilman Ahlfeld, Anja Lode, Michael Gelinsky
Three-dimensional extrusion of two different biomaterials in a core/shell (c/s) fashion has gained much interest in the last couple of years as it allows for fabricating constructs with novel and interesting properties. We now demonstrate that combining high concentrated (16.7 wt%) alginate hydrogels as shell material with low concentrated, soft biopolymer hydrogels as core leads to mechanically stable and robust 3D scaffolds. Alginate, chitosan, gellan gum, gelatin and collagen hydrogels were utilized successfully as core materials-hydrogels which are too soft for 3D plotting of open-porous structures without an additional mechanical support...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27716628/a-comparison-of-different-bioinks-for-3d-bioprinting-of-fibrocartilage-and-hyaline-cartilage
#16
Andrew C Daly, Susan E Critchley, Emily M Rencsok, Daniel J Kelly
Cartilage is a dense connective tissue with limited self-repair capabilities. Mesenchymal stem cell (MSC) laden hydrogels are commonly used for fibrocartilage and articular cartilage tissue engineering, however they typically lack the mechanical integrity for implantation into high load bearing environments. This has led to increased interested in 3D bioprinting of cell laden hydrogel bioinks reinforced with stiffer polymer fibres. The objective of this study was to compare a range of commonly used hydrogel bioinks (agarose, alginate, GelMA and BioINK™) for their printing properties and capacity to support the development of either hyaline cartilage or fibrocartilage in vitro...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27710832/bioprinting-3d-microfibrous-scaffolds-for-engineering-endothelialized-myocardium-and-heart-on-a-chip
#17
Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Su-Ryon Shin, Kai Zhu, Zahra Goli-Malekabadi, Julio Aleman, Cristina Colosi, Fabio Busignani, Valeria Dell'Erba, Colin Bishop, Thomas Shupe, Danilo Demarchi, Matteo Moretti, Marco Rasponi, Mehmet Remzi Dokmeci, Anthony Atala, Ali Khademhosseini
Engineering cardiac tissues and organ models remains a great challenge due to the hierarchical structure of the native myocardium. The need of integrating blood vessels brings additional complexity, limiting the available approaches that are suitable to produce integrated cardiovascular organoids. In this work we propose a novel hybrid strategy based on 3D bioprinting, to fabricate endothelialized myocardium. Enabled by the use of our composite bioink, endothelial cells directly bioprinted within microfibrous hydrogel scaffolds gradually migrated towards the peripheries of the microfibers to form a layer of confluent endothelium...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27694985/3d-bioprinting-matrices-with-controlled-pore-structure-and-release-function-guide-in-vitro-self-organization-of-sweat-gland
#18
Nanbo Liu, Sha Huang, Bin Yao, Jiangfan Xie, Xu Wu, Xiaobing Fu
3D bioprinting matrices are novel platforms for tissue regeneration. Tissue self-organization is a critical process during regeneration that implies the features of organogenesis. However, it is not clear from the current evidences whether 3D printed construct plays a role in guiding tissue self-organization in vitro. Based on our previous study, we bioprinted a 3D matrix as the restrictive niche for direct sweat gland differentiation of epidermal progenitors by different pore structure (300-μm or 400-μm nozzle diameters printed) and reported a long-term gradual transition of differentiated cells into glandular morphogenesis occurs within the 3D construct in vitro...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27689939/three-dimensional-direct-cell-bioprinting-for-tissue-engineering
#19
Saime Burce Ozler, Ezgi Bakirci, Can Kucukgul, Bahattin Koc
Bioprinting is a relatively new technology where living cells with or without biomaterials are printed layer-by-layer in order to create three-dimensional (3D) living structures. In this article, novel bioprinting methodologies are developed to fabricate 3D biological structures directly from computer models using live multicellular aggregates. Multicellular aggregates made out of at least two cell types from fibroblast, endothelial and smooth muscle cells are prepared and optimized. A novel bioprinting approach is proposed in order to continuously extrude cylindrical multicellular aggregates through the bioprinter's glass microcapillaries...
September 30, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27658612/bioink-properties-before-during-and-after-3d-bioprinting
#20
Katja Hölzl, Shengmao Lin, Liesbeth Tytgat, Sandra Van Vlierberghe, Linxia Gu, Aleksandr Ovsianikov
Bioprinting is a process based on additive manufacturing from materials containing living cells. These materials, often referred to as bioink, are based on cytocompatible hydrogel precursor formulations, which gel in a manner compatible with different bioprinting approaches. The bioink properties before, during and after gelation are essential for its printability, comprising such features as achievable structural resolution, shape fidelity and cell survival. However, it is the final properties of the matured bioprinted tissue construct that are crucial for the end application...
2016: Biofabrication
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