Jeffrey R Singer, Emily G Blosser, Carlene L Zindl, Daniel J Silberger, Sean Conlan, Vincent A Laufer, Daniel DiToro, Clay Deming, Ranjit Kumar, Casey D Morrow, Julia A Segre, Michael J Gray, David A Randolph, Casey T Weaver
Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome, neonatal dysbiosis and LOS. Using a model of LOS, we found that components of the developing microbiome were both necessary and sufficient to prevent LOS. Maternal antibiotic exposure that eradicated or enriched transmission of Lactobacillus murinus exacerbated and prevented disease, respectively...
November 2019: Nature Medicine