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https://www.readbyqxmd.com/read/28632486/randomized-noncomparative-phase-ii-trial-of-early-switch-from-docetaxel-to-cabazitaxel-or-vice-versa-with-integrated-biomarker-analysis-in-men-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer
#1
Emmanuel S Antonarakis, Scott T Tagawa, Giuseppe Galletti, Daniel Worroll, Karla Ballman, Marie Vanhuyse, Guru Sonpavde, Scott North, Costantine Albany, Che-Kai Tsao, John Stewart, Atef Zaher, Ted Szatrowski, Wei Zhou, Ada Gjyrezi, Shinsuke Tasaki, Luigi Portella, Yang Bai, Timothy B Lannin, Shalu Suri, Conor N Gruber, Erica D Pratt, Brian J Kirby, Mario A Eisenberger, David M Nanus, Fred Saad, Paraskevi Giannakakou
Purpose The TAXYNERGY trial ( ClinicalTrials.gov identifier: NCT01718353) evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance to taxanes in men with chemotherapy-naïve, metastatic, castration-resistant prostate cancer. Patients and Methods Patients were randomly assigned 2:1 to docetaxel or cabazitaxel. Men who did not achieve ≥ 30% prostate-specific antigen (PSA) decline by cycle 4 (C4) switched taxane. The primary clinical endpoint was confirmed ≥ 50% PSA decline versus historical control (TAX327)...
June 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28620762/using-raman-spectroscopy-in-studying-the-effect-of-propylene-glycol-oleic-acid-and-their-combination-on-the-rat-skin
#2
Eman Atef, Njoud Altuwaijri
The permeability enhancement effect of oleic acid (OA) and propylene glycol (PG) as well as their (1:1 v/v) combined mixture was studied using rat skin. The percutaneous drug administration is a challenge and an opportunity for drug delivery. To date, there is limited research that illustrates the mechanism of penetration enhancers and their combinations on the skin. This project aims to explore the skin diffusion and penetration enhancement of PG, OA, and a combination of PG-OA (1:1 v/v) on rat skin and to identify the potential synergistic effect of the two enhancers utilizing Raman spectroscopy...
June 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28611261/non-neoplastic-portal-vein-thrombosis-in-hcv-cirrhosis-patients-is-it-an-immuno-inflammatory-disorder
#3
Mona Abu El-Makarem, Atef El-Akad, Moustafa Elian, Tahra Sherif, Ragaa El-Shaheed, Aliaa Abd El Fatah, Douaa Sayed, Rania Bakry, Aisha Mahmoud
BACKGROUND AND AIMS: Portal vein thrombosis (PVT) is a critical complication in cirrhotic patients. We explored the role of the activated factor VII-antithrombin (FVIIa-AT) complex and enhanced monocytic tissue factor (TF) expression in the development and prediction of non-neoplastic PVT in cirrhotic patients. MATERIAL AND METHODS: A total of 30 HCV-cirrhosis patients were included in our study. They were compared to 35 cirrhotic patients without PVT, 15 non-cirrhotic patients with PVT, and 15 healthy controls...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28601053/species-identification-and-prevalence-of-house-dust-mites-as-respiratory-allergen-in-kindergartens-of-the-bandar-abbas-city
#4
Moussa Soleimani-Ahmadi, Mehdi Zare, Seyyed Mohammad Abtahi, Atefe Khazeni
The aim of this study was to identify the species and prevalence of house dust mites (HDMs) in kindergartens in Bandar Abbas, south of Iran. In this study 10 kindergartens were selected randomly in five areas of Bandar Abbas. Two dust samples were collected from each sampling place with a vacuum cleaner. Mites were isolated and mounted in Hoyer's medium and identified using a morphology-based key. In total, 1758 mites were collected and identified, whichconsisted of five species: Dermatophagoides pteronyssinus (31...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28598310/in-vitro-activities-of-vancomycin-and-linezolid-against-biofilm-producing-methicillin-resistant-staphylococci-species-isolated-from-catheter-related-bloodstream-infections-from-an-egyptian-tertiary-hospital
#5
Asmaa A Hashem, Noha M Abd El Fadeal, Atef S Shehata
PURPOSE: Catheter-related bloodstream infections (CRBSIs) are among the most common hospital-acquired infections. We aimed to survey methicillin resistance, biofilm production and susceptibility to vancomycin, linezolid and other antibiotics for staphylococci isolated from CRBSIs. METHODOLOGY: Fifty-eight isolates [20 S. aureus and 38 coagulase-negative staphylococci (CoNS; 20 Staphylococcusepidermidis, nine Staphylococcushaemolyticus, three Staphylococcusschleiferi, two Staphylococcuswarneri and four Staphylococcuslugdunensis)] were tested for methicillin resistance by cefoxitin disk diffusion and detection of the mecA gene by PCR; biofilm-forming ability using Congo red agar and tissue culture plate methods; susceptibility to ciprofloxacin, clindamycin, cotrimoxazole, erythromycin, gentamicin, linezolid, rifampicin and tetracycline; and MIC determination for vancomycin...
June 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28594327/different-tcr-induced-t-lymphocyte-responses-are-potentiated-by-stiffness-with-variable-sensitivity
#6
Michael Saitakis, Stéphanie Dogniaux, Christel Goudot, Nathalie Bufi, Sophie Asnacios, Mathieu Maurin, Clotilde Randriamampita, Atef Asnacios, Claire Hivroz
T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4(+) T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa)...
June 8, 2017: ELife
https://www.readbyqxmd.com/read/28590397/normal-nasopharyngeal-measurement-by-computed-tomography-in-adult
#7
Mohammad Waheed El-Anwar, Atef Hamed Ali, Ismail Elnashar, Inas M Elfiki, Ayman F Ahmed, Ghada Abdulmonaem
BACKGROUND: This study aims to investigate the detailed computed tomography (CT) measurement of the nasopharynx (NP) in normal adult detecting mean of its dimension and relation of that measurement to that of the sphenoid sinus. METHODOLOGY/PRINCIPAL: A normal paranasal CT scan and a straight nasal septum of 128 individuals (256 sphenoid sinuses) were included in the study. Axial images were acquired with multiplanar reformates to obtain delicate details in coronal and sagittal planes for all subjects...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28589248/quercetin-and-tin-protoporphyrin-attenuate-hepatic-ischemia-reperfusion-injury-role-of-ho-1
#8
Yara Atef, Hassan M El-Fayoumi, Yousra Abdel-Mottaleb, Mona F Mahmoud
Ischemia reperfusion (IR) injury occurs in many clinical situations such as organ transplantation and hepatectomies resulting in oxidative stress and immune activation. Heme oxygenase-1(HO-1) is the rate-limiting step in the heme-degradation pathway and has a critical cytoprotective role. Induction of HO-1 improves liver I/R injury. Quercetin, a plant pigment (flavonoid), is an antioxidant and HO-1 inducer. Tin protoporphyrin (SnPP) is a HO-1 inhibitor. This study was designed to investigate the protective effect of quercetin in hepatic I/R injury and the role of HO-1...
June 6, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28579346/combined-spontaneous-bacterial-empyema-and-peritonitis-in-cirrhotic-patients-with-ascites-and-hepatic-hydrothorax
#9
Anwar Mohamed, Mohammed Atef, Ayman Alsebaey, Mahmoud Musa Elhabshy, Mohsen Salama
BACKGROUND AND STUDY AIMS: Spontaneous bacterial empyema (SBEM) is an underestimated condition in patients with ascites and hepatic hydrothorax with a high mortality. This study aimed to find whether spontaneous bacterial peritonitis (SBP) is a prerequisite for SBEM. PATIENTS AND METHODS: 3000 HCV-related cirrhotic patients with ascites and hydrothorax were screened for the presence of SBP (ascitic fluid neutrophils >250/mm(3)) and SBEM (positive pleural fluid culture and neutrophils >250/mm(3) or negative pleural fluid culture and neutrophils >500/mm(3) with no evidence of pneumonia/parapneumonic effusion on chest radiograph or CT)...
June 1, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28574805/the-development-of-fviii-inhibitors-in-relation-to-il10-gene-polymorphism-in-hemophilia-a-egyptian-pediatric-patients
#10
Hoda Sadek, Ilham Youssry, Nihal Salah Eldeen Ibrahim, Amany Ahmed Abou-Elalla, Gehad Atef, Somaia Mohammed Mousa
BACKGROUND: Development of inhibitors against Factor VIII (FVIII) in hemophilia A patients is a serious complication of therapy. Many cytokines, including interleukin-10 (IL10), may affect inhibitor development; however, literature data are not sufficient to prove this association. The aim of this study was to investigate the relation between FVIII inhibitor formation and IL10-1082A/G polymorphism among Egyptian hemophiliacs. METHODS: Patients were screened for FVIII inhibitors using the Bethesda method...
June 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28520766/transcriptomic-analysis-of-salt-stress-responsive-genes-in-rhazya-stricta
#11
Nahid H Hajrah, Abdullah Y Obaid, Ahmed Atef, Ahmed M Ramadan, Dhivya Arasappan, Charllotte A Nelson, Sherif Edris, Mohammed Z Mutwakil, Alawia Alhebshi, Nour O Gadalla, Rania M Makki, Madgy A Al-Kordy, Fotouh M El-Domyati, Jamal S M Sabir, Mohammad A Khiyami, Neil Hall, Ahmed Bahieldin, Robert K Jansen
Rhazya stricta is an evergreen shrub that is widely distributed across Western and South Asia, and like many other members of the Apocynaceae produces monoterpene indole alkaloids that have anti-cancer properties. This species is adapted to very harsh desert conditions making it an excellent system for studying tolerance to high temperatures and salinity. RNA-Seq analysis was performed on R. stricta exposed to severe salt stress (500 mM NaCl) across four time intervals (0, 2, 12 and 24 h) to examine mechanisms of salt tolerance...
2017: PloS One
https://www.readbyqxmd.com/read/28504292/microstructure-degradation-of-ni-cgo-anodes-for-solid-oxide-fuel-cells-after-long-operation-time-using-3d-reconstructions-by-fib-tomography
#12
Atef Zekri, Martin Knipper, Jürgen Parisi, Thorsten Plaggenborg
Solid oxide fuel cells (SOFCs) are electrochemical conversion devices, which essentially consist of two porous electrodes separated by a dense, oxide ion conducting electrolyte. The performance and the durability of SOFCs strongly depend on the electrode microstructure. In this paper, the impact of a relatively long exposure time (up to 20 000 h) under realistic operation terms (temperature (T) = 850 °C, current density (J) = 190-250 mA cm(-2)) in the kinetics of microstructural degradation are investigated for porous nickel (Ni)/ceria gadolinium oxide (CGO) anodes, to understand the microstructural evolution in SOFC cermet anodes...
May 31, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28496486/chemical-composition-and-antimicrobial-activities-of-essential-oils-of-some-coniferous-plants-cultivated-in-egypt
#13
Taghreed A Ibrahim, Atef A El-Hela, Hala M El-Hefnawy, Areej M Al-Taweel, Shagufta Perveen
Family Cupressaceae is the largest coniferous plant family. Essential oils of many species belonging to family Cupressaceae are known to have several biological activities specially antimicrobial activity. The essential oils from aerial parts of Calocedrus decurrens Torr., Cupressus sempervirens stricta L. and Tetraclinis articulata (Vahl) Mast. were prepared by hydrodistillation. The chemical composition of the essential oils has been elucidated by gas chromatography-mass spectroscopy analysis. The prepared essential oils were examined against selected species of Gram-positive, Gram-negative bacteria and Candida species...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28490971/chemoprotective-effect-of-omega-3-fatty-acids-on-thioacetamide-induced-hepatic-fibrosis-in-male-rats
#14
Atef M Al-Attar, Hayfa A Al-Rethea
The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA) in male rats. The experimental animals were divided into four groups. The first group was received saline solution and served as control. The second group was given 250 mg/kg body weight of TAA. The third group was treated with omega-3 fatty acids and TAA. The fourth group was given saline solution and supplemented with omega-3 fatty acids. Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28484648/the-effectiveness-of-pre-and-postoperative-infliximab-in-controlling-beh%C3%A3-et-s-disease-posterior-uveitis-in-patients-undergoing-vitrectomy-a-preliminary-study
#15
Hossam El Din Mohamed Khalil, Heba A El Gendy, Hala Ahmed Raafat, Hazem Effat Haroun, Tamer Atef Gheita, Hossam Mahmoud Bakir
Purpose. To evaluate the short-term effectiveness of infliximab in controlling ocular manifestations in Behçet's Disease (BD) patients candidate for pars plana vitrectomy, if given in a regimen before and after the planned procedure. Patients and Methods. 30 eyes of 27 adult male BD patients with a mean age of 35.56 yrs presented with refractory posterior uveitis not responding to immunosuppressive drugs and candidate for vitrectomy were included. Infliximab was given in a dose of 5 mg/kg intravenous infusion once every two weeks for 3 treatment sessions before the intended vitrectomy followed by 3 treatment sessions at two-week intervals, after vitrectomy...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28469688/significance-of-abnormal-myocardial-perfusion-scans-in-candidates-for-orthotopic-liver-transplantation
#16
Atefe Esmaili, Saeed Farzanefar, Alireza Emami-Ardakani, Mehrshad Abbasi
Background: The implications of cardiac risk stratification before orthotopic liver transplantation (OLT) are not well established. We studied the usefulness of myocardial perfusion imaging (MPI) in this scenario. Methods: MPI data of 24 patients (9 females), candidates of OLT, were collected. They underwent MPI as part of their preoperative risk assessment. MPIs were interpreted by 2 nuclear physicians, who had access to clinical data, scan, and semi-quantification results (i.e., quantitative perfusion single-photon emission tomography (SPECT) [QPS] and quantitative gated SPECT [QGS])...
January 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28469305/a-novel-composite-two-stage-urethroplasty-for-complex-penile-strictures-a-multicenter-experience
#17
Pankaj M Joshi, Guido Barbagli, Vikram Batra, Sandesh Surana, Atef Hamouda, Salvatore Sansalone, Dimitris Costi, Massimo Lazzeri, Craig Hunter, Devang J Desai, Fabio Castiglione, Sanjay B Kulkarni
INTRODUCTION: Complex penile strictures are usually repaired using a two-stage urethroplasty. Buccal mucosal graft (BMG) placed in the first stage can have a significant contraction rate, which may require a subsequent revision surgery. We describe a composite two-stage penile urethroplasty using BMG for patients of complex penile strictures who have some salvageable urethral plate. METHODS: Within a multi-institutional cohort, 82 patients underwent a two-stage urethroplasty for complex stricture of the penile urethra...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28462854/characterization-of-carbapenemases-esbls-and-plasmid-mediated-quinolone-determinants-in-carbapenem-insensitive-escherichia-coli-and-klebsiella-pneumoniae-in-riyadh-hospitals
#18
Mohamed H Al-Agamy, Abduelah Aljallal, Hesham H Radwan, Atef M Shibl
The main objective of this work was to characterize carbapenemases, extended-spectrum β-lactamases (ESBLs), and plasmid-mediated quinolone resistance (PMQR) among carbapenem-insensitive Klebsiella pneumoniae and Escherichia coli clinical isolates which were isolated from three hospitals in Riyadh. Thirty-one carbapenem-insensitive isolates (21 K. pneumoniae and 10 E. coli) were recovered from March 2014 to May 2014. Susceptibility testing and phenotypic detection tests were used to characterize the classes of β-lactamases...
April 24, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28462398/the-frequency-of-gonorrheal-and-chlamydial-infections-in-zanjanian-women-in-2013-2014
#19
Behnaz Molaei, Farnaz Mohmmadian, Maryam Eftekhar, Robabeh Hatami, Atefe Tirkan, Mahsa Kiani
BACKGROUND: Chlamydia trachomatis and Neisseria gonorrhoeae are the most prevalent bacterial sexually transmitted diseases in women. OBJECTIVE: The purpose of this study was to investigate the prevalence of gonorrheal and chlamydial infections and determination of related risk factors in married women with vaginal discharge attending gynecological outpatient department (OPD) in Zanjan in 2013-2014. MATERIALS AND METHODS: In this cross sectional study, 100 married women aged 18-49 years with vaginal discharge were evaluated for signs and symptoms of gonococcal and chlamydial infections...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28438121/leg-elevation-decreases-the-incidence-of-post-spinal-hypotension-in-cesarean-section-a-randomized-controlled-trial
#20
Ahmed Hasanin, Ahmed Aiyad, Ahmed Elsakka, Atef Kamel, Reham Fouad, Mohamed Osman, Ali Mokhtar, Sherin Refaat, Yasmin Hassabelnaby
BACKGROUND: Maternal hypotension is a common complication after spinal anesthesia for cesarean section (CS). In this study we investigated the role of leg elevation (LE) as a method for prevention of post-spinal hypotension (PSH) for cesarean section. METHODS: One hundred and fifty full term parturients scheduled for CS were included in the study. Patients were randomized into two groups: Group LE (leg elevation group, n = 75) and group C (Control group, n = 75)...
April 24, 2017: BMC Anesthesiology
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