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https://www.readbyqxmd.com/read/28214189/economic-assessment-of-rotavirus-vaccination-in-saudi-arabia
#1
Amal Y A Al-Aidaroos, Baudouin Standaert, Kinga Meszaros, Atef M Shibl
In the Kingdom of Saudi Arabia (KSA), rotavirus universal mass vaccination has been introduced in 2013, however, there is limited information available on the economic benefit and the epidemiological impact of the programme to date. We used a Markov cohort model to evaluate and compare the economic value of rotavirus vaccination with no vaccination in a birth cohort of 562,428 infants. This lifetime analysis considered the societal perspective. Model input was obtained through consensus of local experts after two rounds of evaluation of the proposed estimates...
February 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28192751/ameliorative-potential-of-linagliptin-and-or-calcipotriol-on-bleomycin-induced-lung-fibrosis-in-vivo-and-in-vitro-study
#2
Ahmed M Kabel, Maaly A Abd Elmaaboud, Aliaa Atef, Mohammed H Baali
Pulmonary fibrosis is a serious medical problem that may significantly compromise respiratory functions. The aim of this work was to study the effect of linagliptin and/or calcipotriol on bleomycin-induced pulmonary fibrosis and to explore the possible mechanisms underlying this effect. One hundred and twenty male C57BL/6 mice were divided into 6 equal groups as follows: control group; bleomycin group; bleomycin+carboxymethylcellulose group; bleomycin+linagliptin group; bleomycin+calcipotriol group and bleomycin+linagliptin+calcipotriol group...
February 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28167508/hypoxia-causes-down-regulation-of-dicer-in-hepatocellular-carcinoma-which-is-required-for-up-regulation-of-hypoxia-inducible-factor-1%C3%AE-and-epithelial-mesenchymal-transition
#3
Ahmed Atef Ibrahim, Christian Schmithals, Eric Kowarz, Verena Köberle, Bianca Kakoschky, Thomas Pleli, Otto Kollmar, Scarlett Nitsch, Oliver Waidmann, Fabian Finkelmeier, Stefan Zeuzem, Horst-Werner Korf, Tobias Schmid, Andreas Weigert, Bernd Kronenberger, Rolf Marschalek, Albrecht Piiper
PURPOSE: A role of Dicer, which converts precursor miRNAs to mature miRNAs, in the tumor-promoting effect of hypoxia is currently emerging in some tumor entities. Its role in hepatocellular carcinoma (HCC) is unknown. EXPERIMENTAL DESIGN: HepG2 and Huh-7 cells were stably transfected with an inducible Dicer expression vector and were exposed to hypoxia/normoxia. HepG2-Dicer xenografts were established in nude mice; hypoxic areas and Dicer were detected in HCC xenografts and HCCs from mice with endogenous hepatocarcinogenesis; epithelial mesenchymal transition (EMT) markers were analyzed by immunohistochemistry or by immunoblotting...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28163844/effect-of-entonox-on-reducing-the-need-for-pethidine-and-the-relevant-fetal-and-maternal-complications-for-painless-labor
#4
Alireza Sharifian Attar, Atefe Shirinzadeh Feizabadi, Lida Jarahi, Laya Shirinzadeh Feizabadi, Shima Sheybani
BACKGROUND: Pain relief during labour is one of the major concerns in obstetrics; severe labor pain causes fear of the next pregnancy, and interferes with the mother's family relationship. OBJECTIVE: The aim of this study was to evaluate the analgesic effects of Entonox during labor on reducing the need for pethidine (Meperidine) and fetal-maternal complications. METHODS: This double-blind randomized clinical trial was conducted on pregnant women who were candidates for vaginal delivery in Educational Hospitals of Mashhad University of Medical Sciences, Iran between January 2014 and November 2015...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28162861/effect-of-omegaven-on-mast-cell-concentration-in-diabetic-wound-healing
#5
Saeid Babaei, Hadi Ansarihadipour, Mahmoodreza Nakhaei, Mohammadreza Darabi, Parvindokht Bayat, Mohammadhassan Sakhaei, Maryam Baazm, Atefe Mohammadhoseiny
Diabetic wound healing is a complicated process. In all over the world 15% of 200 million diabetic people suffer from diabetic foot problems. Mast cells are known to participate in three phases of wound healing: the inflammatory reaction, angiogenesis and extracellular-matrix reabsorption. The inflammatory reaction is mediated by released histamine and arachidonic acid metabolites. Omega-3 fatty acids alter proinflammatory cytokine production during wound healing which affects the presence of inflammatory cells in wound area as well, but how this events specifically influences the presence of mast cells in wound healing is not clearly understood...
December 9, 2016: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28161377/aggressive-angiomyxoma-of-the-penis-the-first-case-report-in-a-9-month-old-infant
#6
Mohamed Atef Mohamed Ahmed, Mohamed Ahmed Uehelie, Abdihamid Mohamed Ali Rage, Ahmed Mohey, Yasser A Noureldin
Aggressive angiomyxoma (AA) is a rare, benign, mesenchymal tumour of the pelvis and perineum. It usually occurs in females at reproductive age. However, rare cases have been reported in male children. We present the first case of aggressive angiomyxoma in the penis of a 9-month-old Somalian boy. The infant presented with large, nodular penile mass. The diagnosis was confirmed following complete surgical removal and histopathological examination. Over 6-month follow-up period, no recurrence was noticed. Therefore, we recommend complete surgical removal of the mass with wide safety margin and long-term follow-up is recommended for the cases of AA...
February 1, 2017: Urology
https://www.readbyqxmd.com/read/28131376/molecular-evidence-of-tick-borne-hemoprotozoan-parasites-theileria-ovis-and-babesia-ovis-and-bacteria-in-ticks-and-blood-from-small-ruminants-in-northern-algeria
#7
Atef Aouadi, Hamza Leulmi, Mehdi Boucheikhchoukh, Ahmed Benakhla, Didier Raoult, Philippe Parola
Using qPCR, standard PCR and/or sequencing, we investigated the presence of tick-associated microorganisms in ticks and blood from sheep and goats from Souk Ahras, Algeria. Borrelia theileri, was detected in (7/120, 5.8%) blood from sheep and (13/120, 10.8%) goats. Anaplasma ovis was screened in (38/73, 52%) Rhipicephalus bursa and (5/22, 22.7%) R. turanicus and in (74/120, 61.7%), (65/120, 54.2%) blood of sheep and goats respectively. Coxiella burnetii tested positive in R. bursa (4/73, 5.5%) and (7/120, 5...
February 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28127611/liquid-identification-by-using-a-micro-electro-mechanical-interdigital-transducer
#8
ThuHang Bui, Bruno Morana, Atef Akhnoukh, Trinh Chu Duc, Pasqualina M Sarro
A surface-acoustic-mode aluminum nitride (AlN) transducer is utilized to determine the type of liquid dropped on the propagation path. It is based on tracking the shrinking droplet radius and observing stagnant liquid molecules during and after the liquid evaporation process. The device configuration is suitable to test small amounts of liquids, in the microliter range. According to both mass loading and physical property mechanisms, eight samples of liquids, isopropanol (IPA), ethanol (ETH), deionized-water (DW), tap water (TW), heptane (HEP), propylene glycol monomethyl ether acetate (PGMEA), hexamethyldisilazane (HMDS) and acetone (ACE), which have different equilibrium vapor pressures, molecular weights and boiling points, are accurately detected...
January 27, 2017: Analyst
https://www.readbyqxmd.com/read/28120151/the-ying-and-yang-of-adenosine-a1-and-a2a-receptors-on-erk1-2-activation-in-a-rat-model-of-global-cerebral-ischemia-reperfusion-injury
#9
Reham M Atef, Azza M Agha, Abdel-Rahman A Abdel-Rhaman, Noha N Nassar
Adenosine impacts cerebral ischemia reperfusion (IR) through the inhibitory A1 and the excitatory A2 receptors. The present study aimed at investigating the contrasting role of pERK1/2 in mediating adenosine A1R (protective) versus A2AR (deleterious) effects in IR. Male Wistar rats subjected to bilateral carotid occlusion (45 min) followed by reperfusion (24 h) exhibited increased pERK1/2 activity, downstream from DAG pathway, along with increases in hippocampal glutamate, c-Fos, NF-κB, TNF-α, iNOS, TBARS, cytochrome c, caspase-3, BDNF, Nrf2, and IL-10 contents...
January 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28112972/sulforaphane-protects-against-sodium-valproate-induced-acute-liver-injury
#10
Entsar A Nazmy, Omar A El-Khouly, Hoda Atef, Eman Said
Drug-induced hepatotoxicity is one of the most commonly encountered obstacles in the field of medical practice. Sodium valproate (VPA) is among many drugs with reported hepatotoxic effects. Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies. The current investigation sheds light on the potential hepatoprotective effect of SFN against VPA-induced liver injury in rats. Twice daily VPA (700 mg/kg, i.p.) for 7 days induced significant biochemical alterations and hepatic histopathological damage...
November 1, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28099759/usefulness-of-the-who-c-model-to-optimize-the-cesarean-delivery-rate-in-a-tertiary-hospital-setting
#11
Hany Abdel-Aleem, Atef Darwish, Ahmad A Abdelaleem, Manal Mansur
OBJECTIVE: To assess use of the C-Model in a tertiary hospital setting in terms of its validity and utility for optimizing the cesarean delivery (CD) rate. METHODS: A prospective observational study included women admitted for delivery at a university teaching hospital in Assiut, Egypt, in 2015. The women were asked about the demographic and obstetric information needed to calculate the probability of CD using the WHO C-Model. A receiver operating characteristic (ROC) curve comparing the predicted and observed CD rates was constructed...
January 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28093543/intestinal-parasite-infections-and-accuracy-of-direct-thin-and-thick-smear-formol-ether-sedimentation-centrifugal-flotation-and-mini-flotac-techniques-among-patients-with-gastrointestinal-tract-disorders-from-the-greater-cairo-region-egypt
#12
Atef H Hussein, Samia M Rashed, Ibrahim A El-Hayawan, Nagwa S Ali, Eman A Abou Ouf, Amira T Ali
The aim of the present study was to assess the frequency of intestinal parasitic infection among patients with gastrointestinal tract disorders from the Greater Cairo region, Egypt. In addition, a comparison was made of the accuracy of direct thin and thick smear, formol-ether sedimentation (FEC), centrifugal flotation (CF), and mini-FLOTAC techniques in the diagnosis of infection. Out of 100 patients, the overall prevalence of parasitic infection was 51%. Only 6% had dual infection. Giardia lamblia was the most common parasite (26%), followed by Hymenolepis nana (20%), Entamoeba coli (8%), and Enterobius vermicularis (3%)...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28090101/a-novel-mathematical-model-for-determining-faculty-workload
#13
Leo R Fitzpatrick, Carol Millette-Snodgrass, Eman Atef
Objective. To develop a mathematical model for determining faculty workload at a college of pharmacy with a team-based learning curriculum. Methods. Using faculty provided data, our model calculated activity and weighted means in teaching, scholarship and service. Subsequently, these data were used to develop departmental and institutional workload models. Results. For the pharmaceutical and biomedical sciences department, percent faculty activity mean values were greatest for service followed by teaching and scholarship...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28053566/protective-effect-of-olive-and-juniper-leaves-extracts-on-nephrotoxicity-induced-by-thioacetamide-in-male-mice
#14
Atef M Al-Attar, Ali A Alrobai, Daklallah A Almalki
This study, for the first time, evaluates the effect of olive and juniper leaves extracts and their combination on thioacetamide (TAA)-induced nephrotoxicity in male mice. The experimental mice were divided into eight groups. Group 1 was served as control. Group 2 was exposed to TAA. Group 3 was treated with TAA and olive leaves extract. Group 4 was subjected to TAA and juniper leaves extract. Group 5 was exposed to TAA and olive and juniper leaves extracts. Groups 6, 7 and 8 were treated with olive, juniper, and olive and juniper leaves extracts respectively...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28050757/implication-of-nrf2-ho-1-pathway-in-the-coloprotective-effect-of-coenzyme-q10-against-experimentally-induced-ulcerative-colitis
#15
Ahmed E Khodir, Hoda Atef, Eman Said, Hassan A ElKashef, Hatem A Salem
PURPOSE: Given the increased incidence of ulcerative colitis worldwide, the current study was designed to investigate the coloprotective potential of CoQ10 against experimentally induced ulcerative colitis (UC) and specify the implicated mechanisms. METHODS: Ulcerative colitis was induced by intracolonic instillation of [2 ml, 3% v/v acetic acid (AA)]. Rats in the different experimental groups received CoQ10 (10 or 30 and 100 mg/kg, orally) for eight consecutive days, either in a protective or curative regimen...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28027086/an-ambulatory-surgery-perioperative-surgical-home-in-kaiser-permanente-settings-practice-and-outcomes
#16
Chunyuan Qiu, Joseph Rinehart, Vu T Nguyen, Maxime Cannesson, Atef Morkos, Diana LaPlace, Narendra S Trivedi, Philip D Mercado, Zeev N Kain
BACKGROUND: The aim of this study is to describe the design, implementation, and associated outcome changes of a Perioperative Surgical Home (PSH) for patients undergoing ambulatory laparoscopic cholecystectomy in a Kaiser Permanente practice model. METHODS: A multidisciplinary planning committee of 15 individuals developed and implemented a new PSH program. A total of 878 subjects were included in the preimplementation period (T-fast), and 1082 patients were included in the postimplementation period (PSH) based on the date of their surgery...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28025965/pharmacokinetics-and-safety-of-nifedipine-gits-candesartan-fixed-dose-combination-in-subjects-with-hepatic-impairment%C3%A2
#17
Yuwang Liu, Michael-Friedrich Boettcher, Anja Schmidt, Sigrun Unger, Atef Halabi, Erich Brendel, Hartmut Blode
OBJECTIVE: To investigate the pharmacokinetic (PK) profiles and safety of nifedipine and candesartan after a single oral dose of nifedipine gastrointestinal therapeutic system (GITS) 30 mg/candesartan cilexetil 8 mg (N30/C8 mg) fixed-dose combination (FDC) in adults with mild to moderate hepatic impairment. METHODS: A phase I, single-center, non-randomized, non-controlled, non-blinded, observational study (N = 32). PK profiles for nifedipine and candesartan were assessed in patients with mild (Child-Pugh A; group 1) or moderate (Child-Pugh B; group 2) hepatic impairment and compared with age- and gender-matched healthy controls (groups 3 and 4) following a single dose of N30/C8 FDC...
December 27, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28002935/growth-performance-nutrients-digestibility-and-blood-metabolites-of-lambs-fed-diets-supplemented-with-probiotics-during-pre-and-post-weaning-period
#18
Atef M Saleem
Objective: Two experiments were conducted to evaluate the effects of inclusion of a commercial probiotic (PRO) contains a mixture of two strains of Pediococcus, Pediococcus acidilactici (1 x 106 cfu/g) and Pediococcus pentosaceus (1.3 x 106 cfu/g), with a dextrose as the carrier compound to a diet based on concentrate mixture and wheat straw on growth performance, digestibility, and blood metabolites of lambs during pre- and post-weaning period. Methods: In exp...
December 17, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27989978/simultaneous-occurrence-of-a-pituitary-adenoma-and-a-foramen-magnum-meningioma-case-report
#19
Atef Ben Nsir, Souhaiel Khalfaoui, Nejib Hattab
The coexistence of a pituitary adenoma and a meningioma is a rare event. In all previously reported cases, only 1 of these 2 tumors was symptomatic. We present the case of 61-year-old woman with no significant medical history who was treated for a simultaneously symptomatic pituitary nonfunctioning adenoma and foramen magnum meningioma. Such an association has not been reported previously.
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27973263/reviewing-the-economic-impact-of-extending-the-national-immunization-program-in-egypt
#20
M Atef, N Khataby
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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