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https://www.readbyqxmd.com/read/27846789/impact-of-breakthrough-pain-on-community-dwelling-cancer-patients-results-from-the-national-breakthrough-pain-study
#1
Nathaniel P Katz, Kavita L Gajria, Alicia C Shillington, Judith J Stephenson, Qing Harshaw
OBJECTIVE: To characterize cancer-related breakthrough pain (BTcP) among community-dwelling patients with cancer. METHODS: Data from the National Breakthrough Pain Study, a cross-sectional observational survey describing breakthrough pain (BTP) in the community, were analyzed for a subset of patients with BTcP. Eligible patients were community-dwelling adults with commercial insurance and insurance claims consistent with cancer and chronic pain who consented to a structured telephone interview...
December 5, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27824886/fatigue-in-type-2-diabetes-impact-on-quality-of-life-and-predictors
#2
Rupali Singh, Cynthia Teel, Carla Sabus, Patricia McGinnis, Patricia Kluding
Fatigue is a persistent symptom, impacting quality of life (QoL) and functional status in people with type 2 diabetes, yet the symptom of fatigue has not been fully explored. The purpose of this study was to explore the relationship between fatigue, QoL functional status and to investigate the predictors of fatigue. These possible predictors included body mass index (BMI), Hemoglobin A1C (HbA1C), sleep quality, pain, number of complications from diabetes, years since diagnosis and depression. Forty-eight individuals with type 2 diabetes (22 females, 26 males; 59...
2016: PloS One
https://www.readbyqxmd.com/read/27811855/effect-of-walking-on-circadian-rhythms-and-sleep-quality-of-patients-with-lung-cancer-a-randomised-controlled-trial
#3
Hui-Mei Chen, Chun-Ming Tsai, Yu-Chung Wu, Kuan-Chia Lin, Chia-Chin Lin
BACKGROUND: Sleep disturbances and poor rest-activity rhythms, which can reduce the quality of life, are highly prevalent among patients with lung cancer. METHODS: This trial investigated the effects of a 12-week exercise intervention including home-based walking exercise training and weekly exercise counseling on 111 lung cancer patients. Participants were randomly allocated to receive the intervention or usual-care. Outcomes included objective sleep (total sleep time, TST; sleep efficiency, SE; sleep onset latency, SOL; and wake after sleep onset, WASO), subjective sleep (Pittsburgh Sleep Quality Index, PSQI), and rest-activity rhythms (r24 and I<O)...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27809930/sleeping-habits-affect-access-to-host-by-chagas-disease-vector-triatoma-dimidiata
#4
Etienne Waleckx, Rafael Pasos-Alquicira, María Jesús Ramírez-Sierra, Eric Dumonteil
BACKGROUND: Chagas disease, caused by the parasite Trypanosoma cruzi, is mainly transmitted by blood-sucking bugs called triatomines. In the Yucatán Peninsula, Mexico, the main vector of T. cruzi is Triatoma dimidiata. While this species may colonize houses in other regions, it is mostly intrusive in Yucatán: it generally lives in sylvan and peridomestic areas, and frequently enters inside homes, likely attracted by potential vertebrate hosts, without establishing colonies. Bugs collected inside homes have a low nutritional status, suggesting that they cannot efficiently feed inside these houses...
November 3, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27797982/does-subjective-sleep-quality-improve-by-a-walking-intervention-a-real-world-study-in-a-japanese-workplace
#5
Hikaru Hori, Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Jun Nakamura
OBJECTIVES: The purpose of this study was to evaluate the impact of a 4-week walking intervention on subjective sleep quality. DESIGN: A prospective open-label study. PARTICIPANTS: A total of 490 healthy workers were included in the study. The 490 participants were divided into a group of 214 participants with exercise habits (exercising group, EG) and a group of 276 participants without exercise habits (non-EG). INTERVENTIONS: A walking intervention with a target of walking 10 000 steps daily for 4 weeks...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27783918/a-randomized-trial-of-long-term-oxygen-for-copd-with-moderate-desaturation
#6
(no author information available yet)
Background Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. Methods We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%)...
October 27, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27765468/memory-consolidation-in-sleep-disorders
#7
Nicola Cellini
In recent years sleep-related memory consolidation has become a central topic in the sleep research field. Several studies have shown that in healthy individuals sleep promotes memory consolidation. Notwithstanding this, the consequences of sleep disorders on offline memory consolidation remain poorly investigated. Research studies indicate that patients with insomnia, obstructive sleep apnea, and narcolepsy often exhibit sleep-related impairment in the consolidation of declarative and procedural information...
September 25, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27752878/treatment-of-rem-sleep-behavior-disorder
#8
REVIEW
Youngsin Jung, Erik K St Louis
REM sleep behavior disorder (RBD) is a common parasomnia disorder affecting between 1 and 7 % of community-dwelling adults, most frequently older adults. RBD is characterized by nocturnal complex motor behavior and polysomnographic REM sleep without atonia. RBD is strongly associated with synucleinopathy neurodegeneration. The approach to RBD management is currently twofold: symptomatic treatment to prevent injury and prognostic counseling and longitudinal follow-up surveillance for phenoconversion toward overt neurodegenerative disorders...
November 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27749546/high-prevalence-of-known-and-unknown-pulmonary-diseases-in-patients-with-claudication-during-exercise-oximetry-a-retrospective-analysis
#9
Christophe Colas-Ribas, Isabelle Signolet, Samir Henni, Mathieu Feuillloy, Frédéric Gagnadoux, Pierre Abraham
The prevalence of pulmonary disease in patients with peripheral artery disease (PAD) has not been extensively studied. Recent evidence has shown that ∼20% of the patients have an atypical chest transcutaneous oxygen pressure (TcpO2) pattern during exercise, which suggests walking-induced hypoxemia. The main objectives of this study were to: (1) describe in a retrospective way the characteristics of the patients suffering from claudication, who attended a treadmill testing in our laboratory, (2) assess the prevalence of known or unknown pulmonary disease...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27718407/a-template-model-of-embodiment-while-dreaming-proposal-of-a-mini-me
#10
Judith Koppehele-Gossel, Ansgar Klimke, Karin Schermelleh-Engel, Ursula Voss
Dreams are usually centered around a dream self capable of tasks generally impossible in waking, e.g. flying or walking through walls. Moreover, the bodily dream self appears relatively stable and insensitive to changes of the embodied wake self, raising the question of whether and to what extent the dream self is embodied. To further explore its determinants, we tested whether the dream self would be affected by either pre-sleep focused attention to a body part or by its experimental alteration during the day...
November 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/27676759/impact-of-fatigue-on-postural-control-in-quiet-standing-in-fibromyalgia
#11
Jacques Vaillant, Perrine Revillet, Anne-Marie Sevenier, Robert Juvin
OBJECTIVE: Fibromyalgia fatigue was described as an overwhelming feeling of tiredness that is not relieved by sleep or rest and is often not in proportion to the effort realized. In fibromyalgia syndrome (FMS), the fatigue has an important functional impact, often limiting the activities of daily living, can induce a state of deconditioning, and causing disturbance of locomotion, whose reasons are not fully understood. The aims of this study was to evaluate the postural performance in quite standing of FMS patients, and to compare them to a control group, and to assess the influence on the posture of a fatigue induced by a short walk...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676746/impaired-control-of-gait-in-patients-with-severe-obstructive-sleep-apnea-is-reversed-by-continuous-positive-airway-pressure-treatment
#12
Sébastien Baillieul, Dominic Perennou, Mathieu Marillier, Jean-Louis Pépin, Samuel Vergès, Bernard Wuyam
OBJECTIVE: Obstructive sleep apnea (OSA) is now widely seen as a major public health issue with widespread societal consequences. In addition to an increased stroke risk, OSA leads to cerebral consequences including cognitive deficits that impair quality of life and daily functioning. In a recent uncontrolled study, moderate-to-severe OSA have been associated with higher stride time variability (STV), reflecting poor gait control (Celle, Annweiler et al., 2014). STV is a clinical marker of cortical gait control linked with cognitive performance and cerebral integrity (Beauchet, Annweiler et al...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27642150/-pulmonary-complications-of-sickle-cell-disease-in-children
#13
T Pincez, L Calamy, Z Germont, A Lemoine, A-A Lopes, A Massiot, J Tencer, C Thivent, A Hadchouel
Acute and chronic pulmonary complications are frequent in sickle cell disease (SCD), with different spectrum and characteristics in children and adults. Chronic hypoxia is frequent and plays a role in several respiratory complications in SCD. Furthermore, hypoxia has been associated with a higher risk of cerebral ischemia. Despite differing oxygen affinity between hemoglobin A and S, standard pulse oximetry was shown to be accurate in diagnosing hypoxia in SCD patients. Whereas acute hypoxia management is similar to non-SCD patients, chronic hypoxia treatment is mainly based on a transfusion program rather than long-term oxygen therapy...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27640358/phenotype-differentiation-of-foxg1-and-mecp2-disorders-a-new-method-for-characterization-of-developmental-encephalopathies
#14
Mandy Ma, Heather R Adams, Laurie E Seltzer, William B Dobyns, Alex R Paciorkowski
OBJECTIVE: To differentiate developmental encephalopathies by creating a novel quantitative phenotyping tool. STUDY DESIGN: We created the Developmental Encephalopathy Inventory (DEI) to differentiate disorders with complex multisystem neurodevelopmental symptoms. We then used the DEI to study the phenotype features of 20 subjects with FOXG1 disorder and 11 subjects with MECP2 disorder. RESULTS: The DEI identified core domains of fine motor and expressive language that were severely impaired in both disorders...
November 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27606280/energy-expenditures-for-activities-of-daily-living-in-korean-young-adults-a-preliminary-study
#15
Kye Hee Cho, Woojin Song, Jungsoo Kim, Eun Ji Jung, Joonyoung Jang, Sang Hee Im, MinYoung Kim
OBJECTIVE: To investigate the energy expenditure (EE) of Korean young adults based on activities refined to a deskbound lifestyle. METHODS: Sixty-four healthy office workers aged between 25 and 46 years participated in this study. EE was expressed as metabolic equivalent of task (MET). Participants were evaluated in terms of their EE during physical activities of sleeping (n=22), typing (n=37), folding laundry (n=34), dishwashing (n=32), studying (n=18), mopping (n=35), walking (n=33), stair climbing (n=23), and running (n=29)...
August 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27594095/significance-of-the-zero-sum-principle-for-circadian-homeostatic-and-allostatic-regulation-of-sleep-wake-state-in-the-rat
#16
Richard Stephenson, Aimee M Caron, Svetlana Famina
Sleep-wake behavior exhibits diurnal rhythmicity, rebound responses to acute total sleep deprivation (TSD), and attenuated rebounds following chronic sleep restriction (CSR). We investigated how these long-term patterns of behavior emerge from stochastic short-term dynamics of state transition. Male Sprague-Dawley rats were subjected to TSD (1day×24h, N=9), or CSR (10days×18h TSD, N=7) using a rodent walking-wheel apparatus. One baseline day and one recovery day following TSD and CSR were analyzed. The implications of the zero sum principle were evaluated using a Markov model of sleep-wake state transition...
September 1, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27568890/the-effect-of-supplemental-oxygen-in-obesity-hypoventilation-syndrome
#17
Juan F Masa, Jaime Corral, Auxiliadora Romero, Candela Caballero, Joaquin Terán-Santos, Maria L Alonso-Álvarez, Teresa Gomez-Garcia, Mónica González, Soledad López-Martínez, Pilar De Lucas, José M Marin, Sergi Marti, Trinidad Díaz-Cambriles, Eusebi Chiner, Miguel Merchan, Carlos Egea, Ana Obeso, Babak Mokhlesi
STUDY OBJECTIVES: Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there is a paucity of data regarding its efficacy and safety. The objective of this study was to assess the medium-term treatment efficacy of adding supplemental oxygen therapy to commonly prescribed treatment modalities in OHS. METHODS: In this post hoc analysis of a previous randomized controlled trial, we studied 302 sequentially screened OHS patients who were randomly assigned to noninvasive ventilation, continuous positive airway pressure, or lifestyle modification...
October 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27553583/visual-signs-and-symptoms-of-corticobasal-degeneration
#18
REVIEW
Richard A Armstrong
Corticobasal degeneration is a rare, progressive neurodegenerative disease and a member of the 'parkinsonian' group of disorders, which also includes Parkinson's disease, progressive supranuclear palsy, dementia with Lewy bodies and multiple system atrophy. The most common initial symptom is limb clumsiness, usually affecting one side of the body, with or without accompanying rigidity or tremor. Subsequently, the disease affects gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs...
November 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27544835/sleep-disordered-breathing-and-nocturnal-hypoxemia-in-young-adults-with-sickle-cell-disease
#19
P L Whitesell, O Owoyemi, P Oneal, M Nouraie, E S Klings, A Rock, T A Mellman, T Berihun, J Lavella, R E Taylor, S P Perrine
Sleep-disordered breathing (SDB) is reported in up to 69% of adolescents and children with sickle cell disease (SCD) [1], but data regarding the prevalence of SDB in adults with SCD are limited. In order to obtain a preliminary assessment of the frequency and degree of sleep-related hypoxemia and potential associations with cardiovascular function in adults with SCD, we conducted overnight sleep studies, 6-min walk tests, echocardiograms, and hematologic and chemistry panels, calculated the Pittsburgh sleep quality index (PSQI), and conducted fatigue- and health-related quality-of-life measurement in 20 young adults with SCD visiting a sickle cell clinic for routine care...
June 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27531146/gait-disturbance-as-the-presenting-symptom-in-young-children-with-anti-nmda-receptor-encephalitis
#20
Anusha K Yeshokumar, Lisa R Sun, Jessica L Klein, Kristin W Baranano, Carlos A Pardo
This case series demonstrates a novel clinical phenotype of gait disturbance as an initial symptom in children <3 years old with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Anti-NMDAR encephalitis is one of the most common causes of encephalitis in children, more common than any of the viral encephalitides and the second most common autoimmune cause after acute disseminated encephalomyelitis. Anti-NMDAR encephalitis in children often presents with disrupted speech and sleep patterns followed by progression to motor dysfunction, dyskinesias, and seizures...
September 2016: Pediatrics
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