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https://www.readbyqxmd.com/read/29784928/statistical-machine-learning-of-sleep-and-physical-activity-phenotypes-from-sensor-data-in-96-220-uk-biobank-participants
#1
Matthew Willetts, Sven Hollowell, Louis Aslett, Chris Holmes, Aiden Doherty
Current public health guidelines on physical activity and sleep duration are limited by a reliance on subjective self-reported evidence. Using data from simple wrist-worn activity monitors, we developed a tailored machine learning model, using balanced random forests with Hidden Markov Models, to reliably detect a number of activity modes. We show that physical activity and sleep behaviours can be classified with 87% accuracy in 159,504 minutes of recorded free-living behaviours from 132 adults. These trained models can be used to infer fine resolution activity patterns at the population scale in 96,220 participants...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29780977/modeling-interdependent-and-periodic-real-world-action-sequences
#2
Takeshi Kurashima, Tim Althoff, Jure Leskovec
Mobile health applications, including those that track activities such as exercise, sleep, and diet, are becoming widely used. Accurately predicting human actions in the real world is essential for targeted recommendations that could improve our health and for personalization of these applications. However, making such predictions is extremely difficult due to the complexities of human behavior, which consists of a large number of potential actions that vary over time, depend on each other, and are periodic...
April 2018: Proceedings of the International World-Wide Web Conference
https://www.readbyqxmd.com/read/29766257/the-impact-of-exercise-on-sleep-time-quality-and-disturbance-in-patients-with-rheumatoid-arthritis-a-study-protocol-for-a-pilot-randomised-controlled-trial
#3
Sean G McKenna, Alan E Donnelly, Bente A Esbensen, Alexander D Fraser, Norelee M Kennedy
Poor sleep is an issue for people with rheumatoid arthritis (RA), which may curtail their ability to function appropriately and reduce their activity levels. This paper describes a protocol for a pilot randomised controlled trial of an aerobic exercise intervention compared with exercise advice designed to improve sleep in people with RA. Objectives are to obtain reliable estimates regarding recruitment rates, participant retention and protocol adherence and to generate potential effect size estimates for a main trial...
May 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29761132/the-risk-factors-of-performance-based-early-frailty-in-midlife-and-older-age
#4
Matthew J Peterson
Background: Identifying impairments prior to onset of physical frailty may inform targeted interventions. An objective, clinically feasible early frailty measure, termed performance-based early frailty (PBEF) was developed, and antecedent and current risk factors were examined. Method: Data were from N = 104 participants of the Fels Longitudinal Study. PBEF was derived from age-specific cut points for time to complete five chair stands and walk four meters. "Pre-PBEF" and "PBEF" were defined as impairment in one or both measures, respectively...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29750549/does-breaking-up-prolonged-sitting-when-sleep-restricted-affect-postprandial-glucose-responses-and-subsequent-sleep-architecture-a-pilot-study
#5
Grace E Vincent, Sarah M Jay, Charli Sargent, Katya Kovac, Michele Lastella, Corneel Vandelanotte, Nicola D Ridgers, Sally A Ferguson
This pilot study investigated the impact of breaking up prolonged sitting with light-intensity walking on postprandial glucose responses and sleep architecture. In a randomized, counterbalanced, crossover design, six healthy males completed a sitting condition and an active condition (sitting interrupted with light-intensity walking) for three consecutive days, following 5-h sleep opportunities at night. Postprandial glucose response and sleep (time spent in all stages) was assessed. Breaking up prolonged sitting with light-intensity walking did not affect postprandial glucose responses in sleep-restricted participants; however a small increase (~9 min) in slow-wave sleep was observed...
May 11, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29747936/pulmonary-screening-in-subjects-after-the-fontan-procedure
#6
Deborah R Liptzin, Michael V Di Maria, Adel Younoszai, Michael R Narkewicz, Sarah L Kelly, Kelly R Wolfe, Livia A Veress
OBJECTIVES: To review the pulmonary findings of the first 51 patients who presented to our interdisciplinary single-ventricle clinic after undergoing the Fontan procedure. STUDY DESIGN: We performed an Institutional Review Board-approved retrospective review of 51 patients evaluated following the Fontan procedure. Evaluation included history, physical examination, pulmonary function testing, and 6-minute walk. Descriptive statistics were used to describe the population and testing data...
May 7, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29742443/fluorine-walk-the-impact-of-fluorine-in-quinolone-amides-on-their-activity-against-african-sleeping-sickness
#7
Michael Berninger, Christine Erk, Antje Fuß, Joseph Skaf, Ehab Al-Momani, Ina Israel, Martina Raschig, Paul Güntzel, Samuel Samnick, Ulrike Holzgrabe
Human African Trypanosomiasis, also known as African sleeping sickness, is caused by the parasitic protozoa of the genus Trypanosoma. If there is no pharmacological intervention, the parasites can cross the blood-brain barrier (BBB), inevitably leading to death of the patients. Previous investigation identified the quinolone amide GHQ168 as a promising lead compound having a nanomolar activity against T. b. brucei. Here, the role of a fluorine substitution at different positions was investigated in regard to toxicity, pharmacokinetics, and antitrypanosomal activity...
April 30, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29737195/illness-representations-of-multiple-chronic-conditions-and-self-management-behaviors-in-older-adults-a-pilot-study
#8
Allison R Heid, Rachel Pruchno, Maureen Wilson-Genderson
This article explores the intraindividual variability in illness representations of people with multiple chronic conditions and examines how representations of hypertension and arthritis are associated with self-management. Intraclass correlations determined the proportion of within-person variability in illness representations including Timeline, Consequences, Personal Control, and Timeline-Cyclical for 25 adults aged 64 and older. Within-person consistency across illnesses was present for Timeline and Timeline-Cyclical, but variability across illnesses in Personal Control and Consequences...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29731622/chronic-obstructive-pulmonary-disease-severity-and-its-association-with-obstructive-sleep-apnea-syndrome-impact-on-cardiac-autonomic-modulation-and-functional-capacity
#9
Katiany Thays Lopes Zangrando, Renata Trimer, Luiz Carlos Soares de Carvalho, Guilherme Peixoto Tinoco Arêas, Flávia Cristina Rossi Caruso, Ramona Cabiddu, Meliza Goi Roscani, Fabíola Paula Galhardo Rizzatti, Audrey Borghi-Silva
Background: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. Subjects and methods: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29730614/evaluation-of-the-association-between-sleep-duration-and-tooth-loss-among-korean-adults-data-from-the-korean-national-health-and-nutrition-examination-survey-knhanes-2012-2014
#10
Kyungdo Han, Jun-Beom Park
OBJECTIVES: This study assessed the association between sleep duration and tooth loss using nationally representative data. In this study, a cross-sectional analysis was performed using multivariable logistic regression analysis models. SETTING: The present study analysed data from the Korean National Health and Nutrition Examination Survey between 2012 and 2014. PARTICIPANTS: A total of 14 675 respondents over 19 years old without missing values were included in this study...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29720934/reticulospinal-systems-for-tuning-motor-commands
#11
REVIEW
Robert M Brownstone, Jeremy W Chopek
The pontomedullary reticular formation (RF) is a key site responsible for integrating descending instructions to execute particular movements. The indiscrete nature of this region has led not only to some inconsistencies in nomenclature, but also to difficulties in understanding its role in the control of movement. In this review article, we first discuss nomenclature of the RF, and then examine the reticulospinal motor command system through evolution. These command neurons have direct monosynaptic connections with spinal interneurons and motoneurons...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29701640/wearable-sensors-and-the-assessment-of-frailty-among-vulnerable-older-adults-an-observational-cohort-study
#12
Javad Razjouyan, Aanand D Naik, Molly J Horstman, Mark E Kunik, Mona Amirmazaheri, He Zhou, Amir Sharafkhaneh, Bijan Najafi
Background: The geriatric syndrome of frailty is one of the greatest challenges facing the U.S. aging population. Frailty in older adults is associated with higher adverse outcomes, such as mortality and hospitalization. Identifying precise early indicators of pre-frailty and measures of specific frailty components are of key importance to enable targeted interventions and remediation. We hypothesize that sensor-derived parameters, measured by a pendant accelerometer device in the home setting, are sensitive to identifying pre-frailty...
April 26, 2018: Sensors
https://www.readbyqxmd.com/read/29682064/awake-craniotomy-with-noninvasive-brain-mapping-by-3-tesla-functional-magnetic-resonance-imaging-for-excision-of-low-grade-glioma-a-case-of-a-young-patient-from-pakistan
#13
Atta Ul Aleem Bhatti, Nasir Khan Jakhrani, Maria Adnan Parekh
The past few years have seen increasing support for gross total resection in the management of low-grade gliomas (LGGs), with a greater extent of resection correlated with better overall survival, progression-free survival, and time to malignant transformation. There is consistent evidence in literature supporting extent of safe resection as a good prognostic indicator as well as positively affecting seizure control, symptomatic relief in pressure symptoms, and longer progression-free and total survival. The operative goal in most LGG cases is to maximize the extent of resection for these benefits while avoiding postoperative neurologic deficits...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#14
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29655809/acute-limb-ischemia-in-an-8-year-old-patient-case-report
#15
Young Erben, Samuel M Miller, Brandon J Sumpio, Brian J Dillon, Alfred I Lee, Peter Blume, Bauer E Sumpio, Carlos Mena-Hurtado
We report the case of an 8-year-old patient with a history of nephrotic syndrome (NS), who presented to the emergency department (ED) with right foot pain. The patient's mother described intermittent pain that woke her son from sleep and was accompanied by the foot turning purple and becoming cold to touch. Physical exam revealed capillary refill of over ten seconds in the right and less than two seconds in the left foot. Ankle-brachial indices (ABI) were 0.0 on the right and 0.96 on the left. The patient was admitted and started on therapeutic intravenous heparin...
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29650506/evaluating-the-validity-of-current-mainstream-wearable-devices-in-fitness-tracking-under-various-physical-activities-comparative-study
#16
Junqing Xie, Dong Wen, Lizhong Liang, Yuxi Jia, Li Gao, Jianbo Lei
BACKGROUND: Wearable devices have attracted much attention from the market in recent years for their fitness monitoring and other health-related metrics; however, the accuracy of fitness tracking results still plays a major role in health promotion. OBJECTIVE: The aim of this study was to evaluate the accuracy of a host of latest wearable devices in measuring fitness-related indicators under various seminatural activities. METHODS: A total of 44 healthy subjects were recruited, and each subject was asked to simultaneously wear 6 devices (Apple Watch 2, Samsung Gear S3, Jawbone Up3, Fitbit Surge, Huawei Talk Band B3, and Xiaomi Mi Band 2) and 2 smartphone apps (Dongdong and Ledongli) to measure five major health indicators (heart rate, number of steps, distance, energy consumption, and sleep duration) under various activity states (resting, walking, running, cycling, and sleeping), which were then compared with the gold standard (manual measurements of the heart rate, number of steps, distance, and sleep, and energy consumption through oxygen consumption) and calculated to determine their respective mean absolute percentage errors (MAPEs)...
April 12, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29643758/prevalence-of-supplement-use-in-recreationally-active-kazakhstan-university-students
#17
Denis Vinnikov, Zhanna Romanova, Anar Dushpanova, Karashash Absatarova, Zhazira Utepbergenova
Background: Little is known about the supplements use and recreational sport practices in Kazakhstan university students. Therefore, the aim of this study was to ascertain supplements use prevalence and their predictors in this population. Methods: Cross-sectional survey of both undergraduate and graduate level students was completed in 2017 et al.-Farabi Kazakh National University, the largest higher institution in the country, from almost all Schools. A 45-item questionnaire was used to record physical activity, supplements use, lifestyle attributes (smoking, alcohol, sleep, etc...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29623146/low-back-pain-among-medical-students-in-belgrade-serbia-a-cross-sectional-study
#18
Isidora Vujcic, Nemanja Stojilovic, Eleonora Dubljanin, Nebojsa Ladjevic, Ivana Ladjevic, Sandra Sipetic-Grujicic
Aim: To examine the prevalence of low back pain, to identify self-perceived triggers of low back pain, and to investigate the impact of perceived pain on the daily activities and mood among medical students. Methods: This cross-sectional study enrolled 459 fourth year students at the Faculty of Medicine in Belgrade during December 2014. The anonymous questionnaire was used for data collection. In data analysis, the chi-square test and t -test were used. Results: The lifetime prevalence of low back pain was 75...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29599945/a-digital-compressed-sensing-based-energy-efficient-single-spot-bluetooth-ecg-node
#19
Kan Luo, Zhipeng Cai, Keqin Du, Fumin Zou, Xiangyu Zhang, Jianqing Li
Energy efficiency is still the obstacle for long-term real-time wireless ECG monitoring. In this paper, a digital compressed sensing- (CS-) based single-spot Bluetooth ECG node is proposed to deal with the challenge in wireless ECG application. A periodic sleep/wake-up scheme and a CS-based compression algorithm are implemented in a node, which consists of ultra-low-power analog front-end, microcontroller, Bluetooth 4.0 communication module, and so forth. The efficiency improvement and the node's specifics are evidenced by the experiments using the ECG signals sampled by the proposed node under daily activities of lay, sit, stand, walk, and run...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29596010/whole-body-vibration-on-people-with-sequelae-of-polio
#20
Carolyn P Da Silva, C Lauren Szot, Natasha deSa
PURPOSE: The purpose was to explore the feasibility of whole body vibration (WBV) on polio survivors with/without post-polio syndrome (PPS) by studying its effects on walking speed (10-m walk test), endurance (2-min walk test), pain severity/interference (Brief Pain Inventory [BPI]), sleep quality (Pittsburg Sleep Quality Index), fatigue (Fatigue Severity Scale), leg strength (manual muscle testing and hand-held dynamometry), and muscle cramping (written logs). METHODS: Fifteen individuals completed the study, participating in eight sessions in two 4-week blocks...
March 29, 2018: Physiotherapy Theory and Practice
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