Laura A Wortinger, Anne-Kristin Stavrum, Alexey A Shadrin, Attila Szabo, Sondre Høeg Rukke, Stener Nerland, Runar Elle Smelror, Kjetil Nordbø Jørgensen, Claudia Barth, Dimitrios Andreou, Melissa A Weibell, Srdjan Djurovic, Ole A Andreassen, Marianne Thoresen, Gianluca Ursini, Ingrid Agartz, Stephanie Le Hellard
Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these two disorders. Newborns who experienced perinatal asphyxia have suffered reduced oxygen delivery to the brain around the time of birth, which increases the risk of later psychiatric diagnosis. This study aimed to investigate DNA methylation in blood cells for associations with a history of perinatal asphyxia, a neurologically harmful condition occurring within the biological environment of birth...
January 8, 2024: Translational Psychiatry