James L J Coleman, Margaret A Mouat, Jianxin Wu, Nikola Jancovski, Jaspreet K Bassi, Andrea Y Chan, David T Humphreys, Nadine Mrad, Ze-Yan Yu, Tony Ngo, Siiri Iismaa, Cristobal G Dos Remedios, Michael P Feneley, Andrew M Allen, Robert M Graham, Nicola J Smith
BACKGROUND: Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and detectable as mRNA in the heart and kidney. GPR37L1 ablation was reported to cause hypertension and left ventricular hypertrophy, and thus, we sought to further define the role of GPR37L1 in blood pressure homeostasis. METHODS: We investigated the cardiovascular effects of GPR37L1 using wild-type (GPR37L1wt/wt ) and null (GPR37L1KO/KO ) mice established on a C57BL/6J background, both under baseline conditions and during AngII infusion...
April 6, 2018: Biology of Sex Differences