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https://www.readbyqxmd.com/read/30024967/the-spinal-nr2br-erk2-pathway-as-a-target-for-the-central-sensitization-of-collagen-induced-arthritis-pain
#1
Yingming Xu, Kui Zhang, Jinlin Miao, Peng Zhao, Minghua Lv, Jia Li, Xianghui Fu, Xing Luo, Ping Zhu
OBJECTIVE: Pain management is a huge challenge in the treatment of rheumatoid arthritis (RA), and central sensitization is reportedly involved in the development of pain. The current study was undertaken to explore the possible role of N-methyl-D-aspartate receptors (NMDARs) in the spinal mechanism of central sensitization in RA using a collagen-induced arthritis (CIA) model. METHODS: Mechanical hypersensitivity was assessed in C57BL/6 mice, before and after the induction of CIA via administration of chick type II collagen...
2018: PloS One
https://www.readbyqxmd.com/read/30024591/the-study-on-pathological-mechanism-and-solution-method-for-spinal-cord-ischemia-reperfusion-injury
#2
Y-D Fan, M-L Zhu, D Geng, K Zhou, G-J Du, Z-L Wang
OBJECTIVE: We aimed at investigating the pathological mechanism changing of injury during reperfusion injury, reperfusion time correlation and compliance, finding the blood supply and improving the secondary damage. MATERIALS AND METHODS: A total of 180 patients who underwent a surgical procedure and that received normal saline intraperitoneally immediately after the patients' aortic occlusions were investigated. Patients were divided in three groups. Experimental conditions and programs were designed for various approaches...
July 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30024518/comparison-of-clinical-and-radiological-outcomes-between-modified-gallie-graft-fusion-wiring-technique-and-posterior-cervical-screw-constructs-for-type-ii-odontoid-fractures
#3
Hui Wang, Rui Xue, Lumei Wu, Wenyuan Ding, Lei Ma
The aim of this study was to compare clinical and radiological outcomes between modified Gallie graft fusion-wiring technique and posterior cervical screw constructs for Type II odontoid fractures, and hope to provide references in decision making and surgical planning for both spinal surgeons and surgically treated patients.This is a retrospective study. By retrieving the medical records from January 2005 to July 2015 in our hospital, 53 Type II odontoid fracture patients were reviewed. According to the instrumentation type, patients were divided into 2 groups: Wiring group and Screw group...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30024455/influence-of-the-montage-of-stimulation-electrodes-for-intraoperative-neuromonitoring-during-orthopedic-spine-surgery
#4
Hanneke I Berends, Henricus L Journée
PURPOSE: In transcranial electrical stimulation, induced motor evoked potentials (MEPs) are influenced by the montage of stimulation electrodes. Differences are to be examined between coronal and sagittal stimulation. METHODS: Forty-five patients with idiopathic scoliosis were included. Coronal and sagittal montages were obtained by electrode placement at C3C4 and Cz'F using large contact electrodes. Corkscrew and short needle electrodes were additionally placed at C3C4 in five patients...
July 16, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/30024204/moving-forward-on-the-journey-spirituality-and-family-resilience-after-spinal-cord-injury
#5
Kate Fiona Jones, Pat Dorsett, Grahame Simpson, Lynne Briggs
PURPOSE/OBJECTIVE: The aim of this exploratory study was to consider how spirituality (encompassing meaning, hope and purpose), may facilitate family resilience after spinal cord injury (SCI) over time. Research Method/Design: A qualitative, longitudinal study design was adopted. Semistructured interviews were conducted with 10 family dyads (consisting of the individual with SCI and a nominated family member) on 2 occasions, 6 months apart. A thematic analysis was conducted. RESULTS: Participants reported drawing upon a range of different sources of spirituality, including religious faith, the natural world, inner strength, and meaningful connectedness with others...
July 19, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/30024201/qualitative-study-of-barriers-and-facilitators-to-cigarette-smoking-after-spinal-cord-injury
#6
Lee Saunders, Susan Newman, Richard Aust, James S Krause
OBJECTIVE: Persons with spinal cord injury (SCI) have been shown to have rates of smoking as high as or higher than the general population. As those with SCI are at increased risk for negative health outcomes and early mortality, smoking can be especially dangerous. Our purpose was to assess barriers and facilitators of smoking cessation as defined by those with SCI. METHOD: Participants ( N = 30) were identified through a state surveillance registry ( n = 27) and volunteers from the statewide SCI Association ( n = 3)...
July 19, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/30024052/what-is-the-utility-of-urodynamics-including-ambulatory-and-24-h-monitoring-in-predicting-upper-urinary-tract-damage-in-neuro-urological-patients-and-other-lower-urinary-tract-dysfunction-ici-rs-2017
#7
REVIEW
Angie Rantell, Yutao Lu, Marcio A Averbeck, Jasmin K Badawi, Kevin Rademakers, Tufan Tarcan, Linda Cardozo, Jens C Djurhuus, David Castro-Diaz
AIMS: This article focuses on how, and if, urodynamics can help to identify which kidneys are in danger of deteriorating in function and also gives recommendations for future research. METHODS: At the International Consultation on Incontinence-Research Society (ICI-RS) in 2017, a multi-disciplinary group presented a literature search of what is known about the utility of Urodynamics, including ambulatory, and 24 h monitoring, in predicting upper urinary tract damage in neuro-urological patients and other lower urinary tract dysfunctions...
July 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/30023578/favorable-biological-responses-of-neural-cells-and-tissue-interacting-with-graphene-oxide-microfibers
#8
Ankor González-Mayorga, Elisa López-Dolado, María C Gutiérrez, Jorge E Collazos-Castro, M Luisa Ferrer, Francisco Del Monte, María C Serrano
Neural tissue engineering approaches show increasing promise for the treatment of neural diseases including spinal cord injury, for which an efficient therapy is still missing. Encouraged by both positive findings on the interaction of carbon nanomaterials such as graphene with neural components and the necessity of more efficient guidance structures for neural repair, we herein study the potential of reduced graphene oxide (rGO) microfibers as substrates for neural growth in the injured central neural tissue...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/30022929/region-specific-effects-of-immunotherapy-with-antibodies-targeting-%C3%AE-synuclein-in-a-transgenic-model-of-synucleinopathy
#9
Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson, Fredrik Eriksson, Jessica Sigvardson, Werner Poewe, Gregor K Wenning, Eva Nordström, Nadia Stefanova
Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders. Therefore, targeting α-synuclein species represents an important candidate therapeutic approach. Our aim was to analyze the biological effects of passive immunization targeting α-synuclein and to identify the possible underlying mechanisms in a transgenic mouse model of oligodendroglial α-synucleinopathy...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30022115/label-free-multiphoton-microscopy-reveals-relevant-tissue-changes-induced-by-alginate-hydrogel-implantation-in-rat-spinal-cord-injury
#10
Roberta Galli, Kerim H Sitoci-Ficici, Ortrud Uckermann, Robert Later, Magda Marečková, Maria Koch, Elke Leipnitz, Gabriele Schackert, Edmund Koch, Michael Gelinsky, Gerald Steiner, Matthias Kirsch
The development of therapies promoting recovery after spinal cord injury is a challenge. Alginate hydrogels offer the possibility to develop biocompatible implants with mechanical properties tailored to the nervous tissue, which could provide a permissive environment for tissue repair. Here, the effects of non-functionalized soft calcium alginate hydrogel were investigated in a rat model of thoracic spinal cord hemisection and compared to lesioned untreated controls. Open field locomotion tests were employed to evaluate functional recovery...
July 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30021888/selective-neuronal-silencing-using-synthetic-botulinum-molecules-alleviates-chronic-pain-in-mice
#11
Maria Maiarù, Charlotte Leese, Michelangelo Certo, Irene Echeverria-Altuna, Antonina S Mangione, Jason Arsenault, Bazbek Davletov, Stephen P Hunt
Chronic pain is a widespread debilitating condition affecting millions of people worldwide. Although several pharmacological treatments for relieving chronic pain have been developed, they require frequent chronic administration and are often associated with severe adverse events, including overdose and addiction. Persistent increased sensitization of neuronal subpopulations of the peripheral and central nervous system has been recognized as a central mechanism mediating chronic pain, suggesting that inhibition of specific neuronal subpopulations might produce antinociceptive effects...
July 18, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30021515/increased-expression-of-the-cbl-family-of-e3-ubiquitin-ligases-decreases-interleukin-2-production-in-a-rat-model-of-peripheral-neuropathy
#12
Ji Seon Jeong, Ha Yeon Kim, Byung Seop Shin, Ae Ryoung Lee, Ji Hyun Yoon, Tae Soo Hahm, Ja Eun Lee
BACKGROUND: Interleukin 2 (IL-2) influences the development and severity of pain due to its antinociceptive and immunomodulatory effects. Its production is influenced by the increased expression of c-Cbl (Casitas B-lineage lymphoma proto-oncogene) and Cbl-b E3 ubiquitin ligases. We evaluated the effects on IL-2-mediated changes in c-Cbl and Cbl-b expression in a rat model of chronic neuropathic pain. METHODS: Peripheral neuropathy was induced in adult male Sprague-Dawley rats weighing 250-300 g by chronic spinal nerve ligation...
July 18, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30021049/establishing-an-organotypic-system-for-investigating-multimodal-neural-repair-effects-of-human-mesenchymal-stromal-stem-cells
#13
Devang K Thakor, Lei Wang, Darcy Benedict, Serdar Kabatas, Ross D Zafonte, Yang D Teng
Human mesenchymal stromal stem cells (hMSCs) hold regenerative medicine potential due to their availability, in vitro expansion readiness, and autologous feasibility. For neural repair, hMSCs show translational value in research on stroke, spinal cord injury (SCI), and traumatic brain injury. It is pivotal to establish multimodal in vitro systems to investigate molecular mechanisms underlying neural actions of hMSCs. Here, we describe a platform protocol on how to set up organotypic co-cultures of hMSCs (alone or polymer-scaffolded) with explanted adult rat dorsal root ganglia (DRGs) to determine neural injury and recovery events for designing implants to counteract neurotrauma sequelae...
July 18, 2018: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/30019701/fos-immunoreactivity-in-the-intermediolateral-nucleus-induced-by-tendon-vibration-of-the-m-triceps-surae-in-rats-pretreated-with-a-nitric-oxide-blocker-or-precursor
#14
Inna V Vereshchaka, Andriy V Maznychenko, Olena P Mankivska, Volodymyr O Maisky, Oleh V Vlasenko, Olexandr V Dovgan', Olga L Ocheretna, Tomasz Tomiak, Alexander I Kostyukov
We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7‑nitroindazole (7‑NI) or L‑arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c‑Fos immunoreactivity in the spinal neurons in three groups of rats (tendon‑vibrated, tendon‑vibrated + 7‑NI and tendon‑vibrated + LA)...
2018: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/30019689/evaluation-of-a-toolkit-for-standardizing-clinical-measures-of-muscle-tone
#15
Chris A McGibbon, Andrew Sexton, Glen Hughes, Adam Wilson, Melony Jones, Colleen O'Connell, Kim Parker, Catherine Adans-Dester, Anne O'Brien, Paolo Bonato
To evaluate a new portable toolkit for quantifying upper and lower extremity muscle tone in patients with upper motor neuron syndrome (UMNS).
 Design: Cross-sectional, multi-site, observational trial to test and validate a new technology.
 Setting: Neurorehabilitation clinics at tertiary care hospitals.
 Participants: Four cohorts UMNS patient, >6mo post acquired brain injury, spinal cord injury, multiple sclerosis and cerebral palsy, and a sample of healthy age-matched adult controls...
July 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/30019432/changes-of-motor-corticobulbar-projections-following-different-lesion-types-affecting-the-central-nervous-system-in-adult-macaque-monkeys
#16
M Fregosi, A Contestabile, S Badoud, S Borgognon, J Cottet, J F Brunet, J Bloch, M E Schwab, E M Rouiller
Functional recovery from central nervous system injury is likely to be partly due to a rearrangement of neural circuits. In this context, the corticobulbar (corticoreticular) motor projections onto different nuclei of the Ponto-Medullary Reticular Formation (PMRF) were investigated in thirteen adult macaque monkeys after either, primary motor cortex injury (MCI) in the hand area, or spinal cord injury (SCI) or Parkinson's Disease-like lesions of the nigro-striatal dopaminergic system (PD). A subgroup of animals in both MCI and SCI groups was treated with neurite growth promoting anti-Nogo-A antibodies, whereas all PD animals were treated with autologous neural cell ecosystems (ANCE)...
July 18, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/30018938/synaptophysin-and-caspase-3-expression-on-lumbar-segments-of-spinal-cord-after-sensorimotor-restriction-during-early-postnatal-period-and-treadmill-training
#17
Felipe Stigger, Silvia Barbosa, Marília Rossato Marques, Ethiane Segabinazi, Otávio Américo Augustin, Matilde Achaval, Simone Marcuzzo
The purpose of the current study was to investigate whether locomotor stimulation training could have beneficial effects on spinal cord plasticity consequent to sensorimotor restriction (SR). Male Wistar rats were exposed to SR from postnatal day 2 (P2) to P28. Control and experimental rats underwent locomotor stimulation training in a treadmill from P31 to P52. The intensity of the synaptophysin and caspase-3 immunoreaction was determined on ventral horn of spinal cord. The synaptophysin immunoreactivity was lower in the ventral horn of sensorimotor restricted rats compared to controls animals and was accompanied by an increased caspase-3 immunoreactivity...
June 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30018920/applications-of-psychological-skills-training-for-paralympic-table-tennis-athletes
#18
Tae-Hee Lim, Chang-Yong Jang, David O'Sullivan, Hyunkyoung Oh
This study examined effects of psychological skills training (PST) for Korean national table tennis athletes with spinal cord injuries (SCI), who were training for the 2012 London Paralympics. Participants were three male table tennis players with level two SCI, and all participants attended a total of eight sessions of PST over a period of 3 months. The PST consisted of self-talk, imagery, cognitive reconstructing, and routine. To examine the effectiveness of mental coaching, the Test of Performance Strategies questionnaire was administered over three different periods of time: pre-PST, post-PST, and postcompetition...
June 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30018915/treadmill-exercise-with-bone-marrow-stromal-cells-transplantation-facilitates-neuroprotective-effect-through-bdnf-erk1-2-pathway-in-spinal-cord-injury-rats
#19
You-Mi Kim, Jun-Jang Jin, Sam-Jun Lee, Tae-Beom Seo, Eun-Sang Ji
Transplantation of bone marrow stromal cells (BMSCs) has been known as one of the effective therapeutic methods for functional recovery of spinal cord injury (SCI). Treadmill exercise also facilitates the functional recovery of SCI. Previously, we reported that combination of BMSCs transplantation with treadmill exercise potentiated the locomotor function in SCI rats. In the present study, we investigated whether recovery effect of BMSCs transplantation or treadmill exercise appears through the brain-derived neurotrophic factor (BDNF)-extracellular signal-regulated kinases 1/2 (ERK1/2) pathway...
June 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30018837/retrospondyloptosis-of-the-spine-secondary-to-nonaccidental-trauma
#20
T S Duffin, S W Thomas
Spinal fracture rates from NAT have been reported in <1-3% of spinal injury cases. We present a 13-month-old female who presented with signs of spinal cord injury and was found to have complete retrospondylolisthesis of T12 vertebra and multiple rib fractures in various stages of healing due to NAT. This case reports an extremely severe spinal injury due to NAT of which there are few in the literature and highlights the importance of suspicion of NAT when pediatric patients present with neurologic symptoms and spinal trauma without plausible mechanism of injury...
2018: Case Reports in Pediatrics
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