Read by QxMD icon Read

osteoporosis and spinal cord injury

Hai-Juan Liu, Hua Yan, Jun Yan, Hao Li, Liang Chen, Li-Ren Han, Xiao-Fei Yang
Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in SCI rats, we investigated the expression of neurokinin-1 receptors (NK1R) in BMSC-OB and the effects of SP on bone formation by development of BMSC-OB cultures. Sixty young male Sprague-Dawley rats were randomized into two groups: SHAM and SCI...
2016: PloS One
X Yang, D Hao, H Zhang, B Liu, M Yang, B He
: Treatment with hydrogen sulfide mitigates spinal cord injury-induced sublesional bone loss, possibly through abating oxidative stress, suppressing MMP activity, and activating Wnt/β-catenin signaling. INTRODUCTION: Spinal cord injury (SCI)-induced sublesional bone loss represents the most severe osteoporosis and is resistant to available treatments to data. The present study was undertaken to explore the therapeutic potential of hydrogen sulfide (H2S) against osteoporosis in a rodent model of motor complete SCI...
September 3, 2016: Osteoporosis International
L R Morse, N Nguyen, R A Battaglino, A J Guarino, D R Gagnon, R Zafonte, E Garshick
: We identified a protective bone effect at the knee with lipophilic statin use in individuals with chronic spinal cord injury. Lipophilic statin users gained bone at the knee compared to non-users and wheelchair users lost bone compared to walkers. Ambulation and or statins may be effective osteogenic interventions in chronic spinal cord injury (SCI). INTRODUCTION: SCI increases the risk of osteoporosis and low-impact fractures, particularly at the knee. However, during the chronic phase of SCI, the natural history and factors associated with longitudinal change in bone density remain poorly characterized...
July 13, 2016: Osteoporosis International
Antonio Leone, Marzia Marino, Claudia Dell'Atti, Viola Zecchi, Nicola Magarelli, Cesare Colosimo
The ankylosed spine is prone to fracture even after minor trauma due to its changed biomechanical properties. The two central features of ankylosing spondylitis (AS) that promote the pathological remodeling of the spine are inflammation and new bone formation. AS is also associated with osteoporosis that is attributed to an uncoupling of the bone formation and bone resorption processes. Therefore, bone resorption occurs and promotes weakening of the spine as well as increased risk of vertebral fractures which can be hugely different in terms of clinical relevance...
October 2016: Rheumatology International
Eziamaka C Okafor, Rajiv Gupta, David Estrada, J Andrew Taylor, Can Ozan Tan
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
DA-An Zhou, Yue Ning Deng, Lei Liu, Jian Jun Li
The present study aimed to investigate the effect of traditional Chinese kidney reinforcing and marrow-beneficial medicine (KRMB) on the prevention and treatment of abnormal bone metabolism and osteoporosis (OP) resulting from spinal cord injury (SCI). Rat models of OP following SCI were surgically established. The rats were randomly divided into five groups: Normal; sham operation + KRMB; normal + KRMB; SCI + KRMB; and SCI model group. Bone mineral density (BMD), and the expression of bone gamma-carboxyglutamic-acid containing protein (BGP), hepcidin mRNA and bone sialoprotein (BSP) were recorded at 1, 2, 4, 6, 8 and 10 weeks after the operation...
July 2016: Experimental and Therapeutic Medicine
F Kandziora, P Schleicher, K J Schnake, M Reinhold, B Aarabi, C Bellabarba, J Chapman, M Dvorak, M Fehlings, R Grossman, C K Kepler, C Öner, R Shanmuganathan, L R Vialle, A R Vaccaro
Optimal treatment of injuries to the thoracolumbar spine is based on a detailed analysis of instability, as indicated by injury morphology and neurological status, together with significant modifying factors. A classification system helps to structure this analysis and should also provide guidance for treatment. Existing classification systems, such as the Magerl classification, are complex and do not include the neurological status, while the TLICS system has been accused of over-simplifying the influence of fracture morphology and instability...
February 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
Khalil Ahmad, Sumeera Matee, Saeed Bin Ayaz, Hussain Rashid Ihsan
PURPOSE: Ankylosing spondylitis affects the axial skeleton over many years, predisposing to osteoporosis and subsequent fractures. However, very rarely, it can be incidentally discovered in spinal cord injury cases. CASE REPORT: A 44-year-old male veteran who had previously been well and asymptomatic presented with paraparesis secondary to fractured dorsal vertebrae 10 and 11, following fall from a height. He had been referred to our institute for rehabilitation after surgical fixation of his vertebral fractures...
September 2015: Acta Neurologica Taiwanica
Dragana Kljajić, Fadilj Eminović, Milivoj Dopsaj, Dragan Pavlović, Sladjana Arsić, Jadranka Otašević
OBJECTIVES: Studying the quality of life of people with a spinal cord injury is of great importance as it allows the monitoring of both functioning and adaptation to disability. The aim of this study was to determine the difference between persons with a spinal cord injury involved in sports activities and those not involved in sports activities in relation to their quality of life and the presence of secondary health conditions (pressure ulcers, urinary infections, muscle spasms, osteoporosis, pain, kidney problems-infections, calculosis and poor circulation)...
June 1, 2016: Zdravstveno Varstvo
L M Giangregorio, J C Gibbs, B C Craven
Peripheral quantitative computed tomography (pQCT) can be used to examine bone strength outcomes and muscle size and fatty infiltration. Our research team and others have used it to examine bone loss after spinal cord injury (SCI). However, the high prevalence of restricted lower extremity range of motion, spasticity, edema, excessive muscle atrophy, or severe osteoporosis necessitates changes to standard protocols for screening, positioning during scan acquisition, and analysis methods. This manuscript outlines the challenges that we experienced using pQCT in individuals with SCI, and provides solutions, ones that may also be applicable when using pQCT in individuals with other chronic conditions or in older adults...
August 2016: Osteoporosis International
Farideh A Javid, Roger M Phillips, S Afshinjavid, Roberta Verde, Alessia Ligresti
Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of conventional chemotherapies, there is considerable merit in the development of cannabinoids as potential anticancer therapies...
March 15, 2016: European Journal of Pharmacology
Min Liu, Xianping Wu, Min Tong, Xiyu Wu, Jinping Zhou
STUDY DESIGN: Seventy-five SD rats were randomly assigned to four groups: sham-operated group (Sham, n = 15), complete spinal cord transection (CSCT, n = 20) group, hyperbaric oxygenation group 1 (HBO1, n = 20), and hyperbaric oxygenation group 2 (HBO2, n = 20). OBJECTIVE: The aim of this study was to analyze the impacts of ultra-early hyperbaric oxygen therapy on bone mass of rats with CSCT. SUMMARY OF BACKGROUND DATA: Treatment of patients with complete SCI is still an unresolved medical issue and needs to be further investigated...
July 15, 2016: Spine
Karen L Troy, Leslie R Morse
BACKGROUND: Spinal cord injury (SCI) is associated with a rapid loss of bone mass, resulting in severe osteoporosis and a 5- to 23-fold increase in fracture risk. Despite the seriousness of fractures in SCI, there are multiple barriers to osteoporosis diagnosis and wide variations in treatment practices for SCI-induced osteoporosis. METHODS: We review the biological and structural changes that are known to occur in bone after SCI in the context of promoting future research to prevent or reduce risk of fracture in this population...
2015: Topics in Spinal Cord Injury Rehabilitation
Tiao Lin, Wei Tong, Abhishek Chandra, Shao-Yun Hsu, Haoruo Jia, Ji Zhu, Wei-Ju Tseng, Michael A Levine, Yejia Zhang, Shi-Gui Yan, X Sherry Liu, Dongming Sun, Wise Young, Ling Qin
Spinal cord injury (SCI)-induced bone loss represents the most severe osteoporosis with no effective treatment. Past animal studies have focused primarily on long bones at the acute stage using adolescent rodents. To mimic chronic SCI in human patients, we performed a comprehensive analysis of long-term structural and mechanical changes in axial and appendicular bones in adult rats after SCI. In this experiment, 4-month-old Fischer 344 male rats received a clinically relevant T13 contusion injury. Sixteen weeks later, sublesional femurs, tibiae, and L4 vertebrae, supralesional humeri, and blood were collected from these rats and additional non-surgery rats for micro-computed tomography (µCT), micro-finite element, histology, and serum biochemical analyses...
2015: Bone Research
Tejal Patel, Jamie Milligan, Joseph Lee
OBJECTIVE: To determine the frequency of medical problems, reason for referral/primary complaint, products used, medication-related problems, and polypharmacy in patients with spinal cord injury (SCI) seen at an interprofessional primary care mobility clinic. DESIGN: Retrospective review of medical records of patients with SCI for patient visits between August 2012 and March 2013. METHODS: Data were abstracted from medical records of patients with SCI...
April 8, 2016: Journal of Spinal Cord Medicine
Renato Varoto, Alberto Cliquet
Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetraplegics, cybertherapies toward lessening comorbidities such as cardiovascular diseases, osteoporosis, etc., and the production of new technology for upper and lower limb control. Functional electrical stimulation reflects a unique opportunity for bipedal gait to be achieved by paraplegics and tetraplegics...
October 2015: Artificial Organs
L Gifre, J Vidal, J L Carrasco, A Muxi, E Portell, A Monegal, N Guañabens, P Peris
UNLABELLED: Osteoporosis is a frequent complication related to spinal cord injury (SCI), and data on osteoporosis treatment after SCI is scarce. Treatment with denosumab increases lumbar and femoral BMD and decreases bone turnover markers in individuals with recent SCI. This drug may be a promising therapeutic option in SCI-related osteoporosis. INTRODUCTION: Osteoporosis development is a frequent complication related to SCI, especially at the sublesional level...
January 2016: Osteoporosis International
Delaram Varzi, Sylvie A F Coupaud, Mariel Purcell, David B Allan, Jennifer S Gregory, Rebecca J Barr
After spinal cord injury (SCI), bone loss in the paralysed limbs progresses at variable rates. Decreases in bone mineral density (BMD) in the first year range from 1% (slow) to 40% (rapid). In chronic SCI, fragility fractures commonly occur around the knee, with significant associated morbidity. Osteoporosis treatments await full evaluation in SCI, but should be initiated early and targeted towards patients exhibiting rapid bone loss. The potential to predict rapid bone loss from a single bone scan within weeks of a SCI was investigated using statistical shape modelling (SSM) of bone morphology, hypothesis: baseline bone shape predicts bone loss at 12-months post-injury at fracture-prone sites...
December 2015: Bone
Inanc Karapolat, Hale Uzumcugil Karapolat, Yesim Kirazli, Kazim Capaci, Yesim Akkoc, Kamil Kumanlioglu
[Purpose] This prospective longitudinal study evaluated the changes in bone metabolism markers and bone mineral density of spinal cord injury patients over 3 years. We also assessed the relationships among the bone mineral density, bone metabolism, and clinical data of spinal cord injury patients. [Subjects and Methods] We assessed the clinical data (i.e., immobilization due to surgery, neurological status, neurological level, and extent of lesion) in 20 spinal cord injury patients. Bone mineral density, and hormonal and biochemical markers of the patients were measured at 0, 6, 12, and 36 months...
May 2015: Journal of Physical Therapy Science
Dae-Jean Jo, Yong-Sang Kim, Sung-Min Kim, Ki-Tack Kim, Eun-Min Seo
OBJECT: Most thoracolumbar fractures have a good healing outcome with adequate treatment. However, posttraumatic thoracolumbar kyphosis can occur in a proportion of thoracolumbar fractures after inappropriate treatment, osteoporosis, or osteonecrosis of the vertebral body. There are several surgical options to correct posttraumatic thoracolumbar kyphosis, including anterior, posterior, and combined approaches, which are associated with varying degrees of success. The aim of this study was to assess the use of a modified closing wedge osteotomy for the treatment of posttraumatic thoracolumbar kyphosis and to evaluate the radiographic findings and clinical outcomes of patients treated using this technique...
October 2015: Journal of Neurosurgery. Spine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"