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https://www.readbyqxmd.com/read/28228160/assessment-of-lymphatic-filariasis-prior-to-re-starting-mass-drug-administration-campaigns-in-coastal-kenya
#1
Sammy M Njenga, Henry M Kanyi, Faith M Mutungi, Collins Okoyo, Hadley S Matendechero, Rachel L Pullan, Katherine E Halliday, Simon J Brooker, C Njeri Wamae, Joyce K Onsongo, Kimberly Y Won
BACKGROUND: Lymphatic filariasis (LF) is a debilitating disease associated with extensive disfigurement and is one of a diverse group of diseases referred to as neglected tropical diseases (NTDs) which mainly occur among the poorest populations. In line with global recommendations to eliminate LF, Kenya launched its LF elimination programme in 2002 with the aim to implement annual mass drug administration (MDA) in order to interrupt LF transmission. However, the programme faced financial and administrative challenges over the years such that sustained annual MDA was not possible...
February 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28218274/trapping-of-ivermectin-by-a-pentameric-ligand-gated-ion-channel-upon-open-to-closed-isomerization
#2
Nurit Degani-Katzav, Moshe Klein, Moran Har-Even, Revital Gortler, Ruthi Tobi, Yoav Paas
Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting membrane hyperpolarization that inhibit neural excitation in nematodes. Although IVM activates the C. elegans heteromeric GluClα/β receptor, it cannot activate a homomeric receptor composed of the C. elegans GluClβ subunits...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217582/detection-of-anti-filarial-antibody-among-hydrocele-patients-living-in-an-endemic-area-for-filariasis
#3
Amit Kumar Singh, Loveleena Agarwal, Krishna Lakhmani, Chandrim Sengupta, Ravinder Pal Singh
BACKGROUND: The knowledge of the current prevalence of lymphatic filariasis and its transmission will be helpful in its elimination. Thus, the present study is aimed to determine its prevalence among hydrocele patients which is a common presentation in chronically infected cases. MATERIALS AND METHODS: One hundred patients suffering from hydrocele admitted to the surgical ward were included in the study. Blood samples were collected from the patients during the day hours for the detection of anti-filarial antibody and during night hours to detect the presence of microfilaria by smear examination...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216723/future-research-priorities-for-morbidity-control-of-lymphedema
#4
S R Narahari, Madhur Guruprasad Aggithaya, Christine Moffatt, T J Ryan, Vaughan Keeley, B Vijaya, P Rajendran, S B Karalam, S Rajagopala, N K Kumar, K S Bose, K V Sushma
BACKGROUND: Innovation in the treatment of lower extremity lymphedema has received low priority from the governments and pharmaceutical industry. Advancing lymphedema is irreversible and initiates fibrosis in the dermis, reactive changes in the epidermis and subcutis. Most medical treatments offered for lymphedema are either too demanding with a less than satisfactory response or patients have low concordance due to complex schedules. A priority setting partnership (PSP) was established to decide on the future priorities in lymphedema research...
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28215143/identifying-the-main-mosquito-species-in-the-taiwan-strait-using-dna-barcoding
#5
Bo Gao, Yiliang Fang, Jianqing Zhang, Rongquan Wu, Baohai Xu, Lianhui Xie
Mosquitoes can transmit many types of viruses such West Nile virus and Zika virus and are responsible for virus-causing diseases including malaria, Dengue fever, yellow fever, lymphatic filariasis, and Japanese B encephalitis. On January 19, 2016, the first case of Zika virus infection was identified in Taiwan, which presents the need for studying the mosquito species in the Taiwan Strait and evaluating the risk of the outbreak of this infection. In this study, we collected a total of 144 specimens from 42 mosquito specimens belonging to 9 genera from both sides of the Taiwan Strait during 2013 and 2014...
February 17, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28208221/increased-fas-ligand-expression-of-peripheral-b-1-cells-correlated-with-cd4-t-cell-apoptosis-in-filarial-infected-patients
#6
Rashmi Mishra, Santosh K Panda, Prakash K Sahoo, Bal, A K Satapathy
Cellular hypo responsiveness observed during helminth infections are attributed to factors like Antigen presenting cells (APC) dysfunction, increased Interleukin-10(IL-10), regulatory T cells and induction of CD4(+) T (Th) cell apoptosis.. Increased Fas ligand (FasL) expression on the surface of B-1 cells and induction of apoptosis of Th cells by FasL expressing B-1 cells due to helminth infection was demonstrated in murine model of helminth infection where as profile of FasL expression, Th cell apoptosis and correlation between these two populations of cells in clinical filariasis remain unknown...
February 16, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28207792/partnering-for-impact-integrated-transmission-assessment-surveys-for-lymphatic-filariasis-soil-transmitted-helminths-and-malaria-in-haiti
#7
Alaine Kathryn Knipes, Jean Frantz Lemoine, Franck Monestime, Carl R Fayette, Abdel N Direny, Luccene Desir, Valery E Beau de Rochars, Thomas G Streit, Kristen Renneker, Brian K Chu, Michelle A Chang, Kimberly E Mace, Kimberly Y Won, Patrick J Lammie
BACKGROUND: Since 2001, Haiti's National Program for the Elimination of Lymphatic Filariasis (NPELF) has worked to reduce the transmission of LF through annual mass drug administration with diethylcarbamazine and albendazole. The NPELF reached full national coverage with MDA for LF in 2012, and by 2014, a total of 14 evaluation units (48 communes) had met WHO eligibility criteria to conduct LF transmission assessment surveys (TAS) to determine whether prevalence had been reduced to below a threshold, such that transmission is assumed to be no longer sustainable...
February 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28199317/colorimetric-tests-for-diagnosis-of-filarial-infection-and-vector-surveillance-using-non-instrumented-nucleic-acid-loop-mediated-isothermal-amplification-nina-lamp
#8
Catherine B Poole, Zhiru Li, Andy Alhassan, Dylan Guelig, Steven Diesburg, Nathan A Tanner, Yinhua Zhang, Thomas C Evans, Paul LaBarre, Samuel Wanji, Robert A Burton, Clotilde K S Carlow
Accurate detection of filarial parasites in humans is essential for the implementation and evaluation of mass drug administration programs to control onchocerciasis and lymphatic filariasis. Determining the infection levels in vector populations is also important for assessing transmission, deciding when drug treatments may be terminated and for monitoring recrudescence. Immunological methods to detect infection in humans are available, however, cross-reactivity issues have been reported. Nucleic acid-based molecular assays offer high levels of specificity and sensitivity, and can be used to detect infection in both humans and vectors...
2017: PloS One
https://www.readbyqxmd.com/read/28182075/coexistence-of-microfilaria-with-metastatic-adenocarcinomatous-deposit-from-breast-in-axillary-lymph-node-cytology-a-rare-association
#9
Nibedita Sahoo, Arpita Saha, Pritinanda Mishra
Filariasis is a global social health problem of tropical and sub tropical countries like India. W.bancrofti accounts for 95% of cases of lymphatic filariasis. Microfilaria in cytosmears are a rare finding. We report a case of 55 year old female presented with right axillary swelling with ipsilateral breast lump. Cytosmears from the lymph node aspirate showed metastatic adenocarcinomatous deposits and a bunch of microfilariae surrounding the tumor cells and the aspirate from the breast shows ductal carcinoma...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28181472/circulating-microfilariae-in-haematological-malignancies-do-they-have-a-role-in-pathogenesis
#10
L S Kerketta, K Ghosh
Filariasis is very common in tropical countries. It is endemic in the coastal areas of India. We report four cases of haematological malignancy where peripheral blood and bone marrow smears did not show any microfilariae but conventional cytogenetic preparations from all the four cases showed the presence of parasites. Their morphology confirmed the diagnosis of all cases as bancroftian filariasis. Therefore all types of cytogenetic preparations should be screened carefully in the endemic areas along the coastal zones of India for the presence of this parasite...
February 9, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28168955/breast-filariasis
#11
Ángel Pareja López, Sara M López Saro, Víctor J López Molero, María Del Mar Rico Morales, Miguel A Lorenzo Campos
No abstract text is available yet for this article.
February 3, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28155014/molecular-xenomonitoring-mx-and-transmission-assessment-survey-tas-of-lymphatic-filariasis-elimination-in-two-villages-menoufyia-governorate-egypt
#12
M A Moustafa, M M I Salamah, H S Thabet, R A Tawfik, M M Mehrez, D M Hamdy
Lymphatic filariasis (LF) is focally endemic in Egypt where the female mosquito, Culex pipiens, is responsible for its transmission. The aim of the study was to investigate the impact of implementation of the 13th round of MDA in two Egyptian villages in the Menoufyia Governorate area after failing the transmission assessment survey (TAS) in 2005 using two methods, and to decide whether it is safe to stop MDA in these, as well as in similar implementation units (IUs). To achieve this aim, both the immunochromatographic card test (ICT) and molecular xenomonitoring (MX) techniques were employed...
February 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28146557/costs-of-transmission-assessment-surveys-to-provide-evidence-for-the-elimination-of-lymphatic-filariasis
#13
Molly A Brady, Rachel Stelmach, Margaret Davide-Smith, Jim Johnson, Bolivar Pou, Joseph Koroma, Kingsley Frimpong, Angela Weaver
BACKGROUND: To reach the global goal of elimination of lymphatic filariasis as a public health problem by 2020, national programs will have to implement a series of transmission assessment surveys (TAS) to determine prevalence of the disease by evaluation unit. It is expected that 4,671 surveys will be required by 2020. Planning in advance for the costs associated with these surveys is essential to ensure that the required resources are available for this essential program activity. METHODOLOGY AND FINDINGS: Retrospective cost data was collected from reports from 13 countries which implemented a total of 105 TAS surveys following a standardized World Health Organization (WHO) protocol between 2012 and 2014...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28141812/the-significant-scale-up-and-success-of-transmission-assessment-surveys-tas-for-endgame-surveillance-of-lymphatic-filariasis-in-bangladesh-one-step-closer-to-the-elimination-goal-of-2020
#14
A K M Shamsuzzaman, Rouseli Haq, Mohammad J Karim, Motasim B Azad, A S M Sultan Mahmood, Abul Khair, Muhammad Mujibur Rahman, Israt Hafiz, K D Ramaiah, Charles D Mackenzie, Hayley E Mableson, Louise A Kelly-Hope
BACKGROUND: Bangladesh had one of the highest burdens of lymphatic filariasis (LF) at the start of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) with an estimated 70 million people at risk of infection across 34 districts. In total 19 districts required mass drug administration (MDA) to interrupt transmission, and 15 districts were considered low endemic. Since 2001, the National LF Programme has implemented MDA, reduced prevalence, and been able to scale up the WHO standard Transmission Assessment Survey (TAS) across all endemic districts as part of its endgame surveillance strategy...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28126462/exploring-genetic-variation-in-haplotypes-of-the-filariasis-vector-culex-quinquefasciatus-diptera-culicidae-through-dna-barcoding
#15
Chithravel Vadivalagan, Pushparaj Karthika, Kadarkarai Murugan, Chellasamy Panneerselvam, Paola Del Serrone, Giovanni Benelli
Culex quinquefasciatus (Diptera: Culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. In urban and semi-urban Asian countries, Cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. In the African region, it vectors the Rift Valley fever virus, while in the USA it transmits West Nile, St. Louis encephalitis and Western equine encephalitis virus. In this study, DNA barcoding was used to explore the genetic variation of Cx. quinquefasciatus populations from 88 geographical regions...
January 23, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28120100/molecular-identification-and-phylogenetic-analysis-of-wuchereria-bancrofti-from-human-blood-samples-in-egypt
#16
Iman R Abdel-Shafi, Eman Y Shoieb, Samar S Attia, José M Rubio, Thuy-Huong Ta-Tang, Ayman A El-Badry
Lymphatic filariasis (LF) is a serious vector-borne health problem, and Wuchereria bancrofti (W.b) is the major cause of LF worldwide and is focally endemic in Egypt. Identification of filarial infection using traditional morphologic and immunological criteria can be difficult and lead to misdiagnosis. The aim of the present study was molecular detection of W.b in residents in endemic areas in Egypt, sequence variance analysis, and phylogenetic analysis of W.b DNA. Collected blood samples from residents in filariasis endemic areas in five governorates were subjected to semi-nested PCR targeting repeated DNA sequence, for detection of W...
January 24, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28110082/acute-larvicidal-toxicity-of-five-essential-oils-pinus-nigra-hyssopus-officinalis-satureja-montana-aloysia-citrodora-and-pelargonium-graveolens-against-the-filariasis-vector-culex-quinquefasciatus-synergistic-and-antagonistic-effects
#17
Giovanni Benelli, Roman Pavela, Angelo Canale, Kevin Cianfaglione, Giampiero Ciaschetti, Fabio Conti, Marcello Nicoletti, Sengottayan Senthil-Nathan, Heinz Mehlhorn, Filippo Maggi
Mosquito vector control is facing a number of important and timely challenges, mainly due to the rapid development of pesticide resistance and environmental concerns. In this scenario, screening of botanical resources for their mosquitocidal activity may offer effective and eco-friendly tools against Culicidae vectors. Culex quinquefasciatus Say (Diptera: Culicidae) is a vector of lymphatic filariasis and of dangerous arboviral diseases, such as West Nile and St. Louis encephalitis. In this study, the chemical composition of five essential oils obtained from different plants, namely Pinus nigra J...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/28103243/the-socioeconomic-benefit-to-individuals-of-achieving-the-2020-targets-for-five-preventive-chemotherapy-neglected-tropical-diseases
#18
William K Redekop, Edeltraud J Lenk, Marianne Luyendijk, Christopher Fitzpatrick, Louis Niessen, Wilma A Stolk, Fabrizio Tediosi, Adriana J Rijnsburger, Roel Bakker, Jan A C Hontelez, Jan H Richardus, Julie Jacobson, Sake J de Vlas, Johan L Severens
BACKGROUND: Lymphatic filariasis (LF), onchocerciasis, schistosomiasis, soil-transmitted helminths (STH) and trachoma represent the five most prevalent neglected tropical diseases (NTDs). They can be controlled or eliminated by means of safe and cost-effective interventions delivered through programs of Mass Drug Administration (MDA)-also named Preventive Chemotherapy (PCT). The WHO defined targets for NTD control/elimination by 2020, reinforced by the 2012 London Declaration, which, if achieved, would result in dramatic health gains...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28092103/species-differences-in-hepatic-biotransformation-of-the-anthelmintic-drug-flubendazole
#19
M L Maté, T Geary, C Mackenzie, C Lanusse, G Virkel
Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic used in pigs, poultry, and humans. It has been proposed as a candidate for development for use in elimination programmes for lymphatic filariasis and onchocerciasis in humans. Moreover, FLBZ has shown promise in cancer chemotherapy, particularly for neuroblastoma. This work investigated the hepatic carbonyl-reducing pathway of FLBZ in different species, including humans. Microsomal and cytosolic fractions were obtained from sheep, cattle, pig, hen, rat, and human liver...
January 16, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28070010/low-level-of-hepatitis-b-virus-infection-in-children-20-years-after-initiation-of-infant-vaccination-program-in-wallis-and-futuna
#20
Lorenzo Pezzoli, Jean Pierre Mathelin, Karen Hennessey, Padmasiri Eswara-Aratchige, Jayaprakash Valiakolleri, Sung Hye Kim
The prevalence of hepatitis B virus (HBV) in Wallis and Futuna (WAF) was one of the highest in the Pacific and was the driving factor for introducing hepatitis B (HepB) vaccination in 1992 and HepB birth dose (HepB-BD) in 2006. Using transmission assessment survey (TAS) as a survey platform for eliminating lymphatic filariasis (LF), we assessed HBV surface antigen (HBsAg) seroprevalence, HepB vaccination coverage, and its timeliness among schoolchildren in WAF. From one finger prick of all registered fourth and fifth grade students, we tested HBsAg and filariasis antigen simultaneously, and estimated HepB vaccination coverage and timeliness by reviewing students' immunization cards...
January 9, 2017: American Journal of Tropical Medicine and Hygiene
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