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https://www.readbyqxmd.com/read/29149303/changes-in-cytokine-filarial-antigen-and-dna-levels-associated-with-adverse-events-following-treatment-of-lymphatic-filariasis
#1
Britt J Andersen, Jessica Kumar, Kurt Curtis, Nelly Sanuku, Samson Satofan, Christopher L King, Peter U Fischer, Gary J Weil
Background: Mild to moderate adverse events (AEs) are common after treatment of lymphatic filariasis (LF) and pose a major challenge for the global LF elimination program. We studied changes in cytokine levels and filarial worm components in plasma of subjects with and without AEs following treatment of LF. Methods: Participants (N=24) were hospitalized and monitored for AEs following treatment. Cytokines (27), filarial DNA, circulating filarial antigen (CFA), and immune complexes were measured in plasma samples collected before and after treatment...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29141764/potential-role-for-flubendazole-in-limiting-filariasis-transmission-observations-of-microfilarial-sensitivity
#2
Maeghan O'Neill, Jelil Abdel Njouendou, Michael Dzimianski, Erica Burkman, Patrick Chouna Ndongmo, Jonas A Kengne-Ouafo, Samuel Wanji, Andrew Moorhead, Charles D Mackenzie, Timothy G Geary
Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration. Studies in animal models and one trial in patients infected with Onchocerca volvulus revealed that FLBZ elicits minimal effects on microfilariae (mf). Severe complications after ivermectin (IVM) treatment of patients with high Loa loa microfilaraemia are of great concern. We examined the potential of FLBZ to rapidly kill L. loa mf, the phenomenon proposed to underlie the complications. Mf of L. loa were exposed to FLBZ, its reduced metabolite, albendazole, or IVM in vitro...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141759/cell-type-specific-immunomodulation-induced-by-helminthes-effect-on-metainflammation-insulin-resistance-and-type-2-diabetes
#3
Vivekanandhan Aravindhan, Gowrishankar Anand
Recent epidemiological studies have documented an inverse relationship between the decreasing prevalence of helminth infections and the increasing prevalence of metabolic diseases ("metabolic hygiene hypothesis"). Chronic inflammation leading to insulin resistance (IR) has now been identified as a major etiological factor for a variety of metabolic diseases other than obesity and Type-2 diabetes (metainflammation). One way by which helminth infections such as filariasis can modulate IR is by inducing a chronic, nonspecific, low-grade, immune suppression mediated by modified T-helper 2 (Th2) response (induction of both Th2 and regulatory T cells) which can in turn suppress the proinflammatory responses and promote insulin sensitivity (IS)...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141750/use-of-a-novel-portable-three-dimensional-scanner-to-measure-limb-volume-and-circumference-in-patients-with-filarial-lymphedema
#4
Channa Yahathugoda, Michael J Weiler, Ramakrishna Rao, Lalindi De Silva, J Brandon Dixon, Mirani V Weerasooriya, Gary J Weil, Philip J Budge
The World Health Organization's Global Program to Eliminate Lymphatic Filariasis (LF) has reduced LF transmission worldwide, but millions remain affected by filarial lymphedema. Tools for clinically monitoring lymphedema in developing nations are limited. We tested a novel, portable, infrared three-dimensional (3D) scanner against water displacement (WD) and tape measurement of limb circumference (TMLC) among patients with filarial leg lymphedema in Galle, Sri Lanka. Outcomes were accuracy and reproducibility of scanner measurements...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141050/differential-immunomodulation-in-human-monocytes-versus-macrophages-by-filarial-cystatin
#5
Gopinath Venugopal, Marion Mueller, Susanne Hartmann, Svenja Steinfelder
Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive...
2017: PloS One
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#6
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29122006/single-nucleotide-polymorphisms-in-the-angiogenic-and-lymphangiogenic-pathways-are-associated-with-lymphedema-caused-by-wuchereria-bancrofti
#7
Linda Batsa Debrah, Anna Albers, Alexander Yaw Debrah, Felix F Brockschmidt, Tim Becker, Christine Herold, Andrea Hofmann, Jubin Osei-Mensah, Yusif Mubarik, Holger Fröhlich, Achim Hoerauf, Kenneth Pfarr
BACKGROUND: Lymphedema (LE) is a chronic clinical manifestation of filarial nematode infections characterized by lymphatic dysfunction and subsequent accumulation of protein-rich fluid in the interstitial space-lymphatic filariasis. A number of studies have identified single nucleotide polymorphisms (SNPs) associated with primary and secondary LE. To assess SNPs associated with LE caused by lymphatic filariasis, a cross-sectional study of unrelated Ghanaian volunteers was designed to genotype SNPs in 285 LE patients as cases and 682 infected patients without pathology as controls...
November 9, 2017: Human Genomics
https://www.readbyqxmd.com/read/29118654/overview-of-pacelf-the-pacific-programme-for-the-elimination-of-lymphatic-filariasis
#8
EDITORIAL
Kazuyo Ichimori, Patricia M Graves
No abstract text is available yet for this article.
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29116890/a-test-and-not-treat-strategy-for-onchocerciasis-in-loa-loa-endemic-areas
#9
Joseph Kamgno, Sébastien D Pion, Cédric B Chesnais, Matthew H Bakalar, Michael V D'Ambrosio, Charles D Mackenzie, Hugues C Nana-Djeunga, Raceline Gounoue-Kamkumo, Guy-Roger Njitchouang, Philippe Nwane, Jules B Tchatchueng-Mbouga, Samuel Wanji, Wilma A Stolk, Daniel A Fletcher, Amy D Klion, Thomas B Nutman, Michel Boussinesq
Background Implementation of an ivermectin-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis has been delayed in Central Africa because of the occurrence of serious adverse events, including death, in persons with high levels of circulating Loa loa microfilariae. The LoaScope, a field-friendly diagnostic tool to quantify L. loa microfilariae in peripheral blood, enables rapid, point-of-care identification of persons at risk for serious adverse events. Methods A test-and-not-treat strategy was used in the approach to ivermectin treatment in the Okola health district in Cameroon, where the distribution of ivermectin was halted in 1999 after the occurrence of fatal events related to L...
November 8, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29114130/phylogenetic-study-based-on-28s-rrna-gene-sequencing-of-wuchereria-bancrofti-isolated-from-the-filaria-endemic-areas-of-bankura-district-west-bengal-india
#10
Soumendranath Chatterjee, Swapan Kumar Rudra, Syed Afrin Azmi, Raktima Bandyopadhyay
Lymphatic filariasis is one of the major public health concern in India, and Bankura district of West Bengal is one of the main filaria prone area of the country. Wuchereria bancrofti is the causative organism and Culex quinquefasciatus is the main vector of lymphatic filariasis in India. In the present study, infection and infectivity rate of filarial vector C. quinquefasciatus were determined. The molecular characterization, DNA fingerprinting and phylogenetic analysis of W. bancrofti was done. In the study area, overall vector infection and infectivity rates were 4...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29098868/chemical-composition-and-insecticidal-activity-of-the-essential-oil-from-helichrysum-faradifani-endemic-to-madagascar
#11
Giovanni Benelli, Roman Pavela, Rianasoambolanoro Rakotosaona, Emmanuel Randrianarivo, Marcello Nicoletti, Filippo Maggi
Helichrysum faradifani (Asteraceae) is a perennial shrub growing in rocky and sandy places of Madagascar. The plant is used in the Malagasy traditional medicine as a wound-healing agent, disinfectant and for the treatment of syphilis, diarrhea, cough and headache. In the present work, we analysed the chemical composition of the essential oil distilled from the aerial parts of H. faradifani by GC-MS and evaluated its insecticidal activity against 2nd, 3rd and 4th instar larvae of the lymphatic filariasis vector Culex quinquefasciatus by acute toxicity assays...
November 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29084213/reassessment-of-areas-with-persistent-lymphatic-filariasis-nine-years-after-cessation-of-mass-drug-administration-in-sri-lanka
#12
Ramakrishna U Rao, Sandhya D Samarasekera, Kumara C Nagodavithana, Tharanga D M Dassanayaka, Manjula W Punchihewa, Udaya S B Ranasinghe, Gary J Weil
BACKGROUND: Sri Lanka was one of the first countries to initiate a lymphatic filariasis (LF) elimination program based on WHO guidelines. The Anti-Filariasis Campaign provided 5 annual rounds of mass drug administration (MDA) with diethylcarbamazine plus albendazole in all 8 endemic districts from 2002-2006. Microfilaremia (Mf) prevalences have been consistently <1% in all sentinel and spot-check sites since 2006, and all evaluation units passed school-based transmission assessment surveys (TAS) in 2013...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29080508/exploration-of-antifilarial-activity-of-gold-nanoparticle-against-human-and-bovine-filarial-parasites-a-nanomedicinal-mechanistic-approach
#13
Priya Roy, Swadhin K Saha, Prajna Gayen, Pranesh Chowdhury, Santi P Sinha Babu
The present work seeks to explore the antifilarial activity of biopolymer functionalized gold nanoparticles (AuNPs) against human filarial parasite (Wuchereria bancrofti) through Nrf2 signaling for the first time. A natural polymer, chitosan is used along with Terminalia chebula extract to synthesize AuNPs following the principles of green chemistry. The probable mode of action of AuNPs as filaricidal agent has been investigated in detail using model filarial parasite, Setaria cervi (bovine parasite). Biopolymers inspired AuNPs exhibit superior antifilarial activity against both human and bovine filarial parasites, and are able to induce oxidative stress and apoptotic cell death in filarial parasites mediated through mitochondria...
October 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29078351/albendazole-and-antibiotics-synergize-to-deliver-short-course-anti-wolbachia-curative-treatments-in-preclinical-models-of-filariasis
#14
Joseph D Turner, Raman Sharma, Ghaith Al Jayoussi, Hayley E Tyrer, Joanne Gamble, Laura Hayward, Richard S Priestley, Emma A Murphy, Jill Davies, David Waterhouse, Darren A N Cook, Rachel H Clare, Andrew Cassidy, Andrew Steven, Kelly L Johnston, John McCall, Louise Ford, Janet Hemingway, Stephen A Ward, Mark J Taylor
Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-day period. Here we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the filarial endosymbiont Wolbachia, a proven macrofilaricide target, which reduces treatment from several weeks to 7 days in preclinical models. ABZ had negligible effects on Wolbachia but synergized with minocycline or rifampicin (RIF) to deplete symbionts, block embryogenesis, and stop microfilariae production...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29074038/protection-of-the-house-against-chagas-disease-dengue-leishmaniasis-and-lymphatic-filariasis-a-systematic-review
#15
REVIEW
Olaf Horstick, Silvia Runge-Ranzinger
In light of the recent Zika virus outbreak, vector control has received renewed interest. However, which interventions are efficacious and community effective and how to best deliver them remains unclear. Following PRISMA guidelines, we did a systematic review to assess evidence for applied vector control interventions providing protection against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis at the household level. We searched for published literature and grey literature between Jan 1, 1980, and Nov 30, 2015, and updated our search on April 2, 2017, using databases including the Cochrane, Embase, LILACS, PubMed, Web of Science, and WHOLIS...
October 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29067894/mansonella-ozzardi-and-its-vectors-in-the-new-world-an-update-with-emphasis-on-the-current-situation-in-haiti
#16
C P Raccurt
Mansonella ozzardi (Nematoda: Onchocercidae) is a little studied filarial nematode. This human parasite, transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and blackflies (genus Simulium), is endemic to the Neotropical regions of the New World. With a patchy geographical distribution from southern Mexico to north-western Argentina, human infection with M. ozzardi is highly prevalent in some of the Caribbean islands, along riverine communities in the Amazon Basin, and on both sides of the border between Bolivia and Argentina...
October 25, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29065795/antifilarial-activity-of-caffeic-acid-phenethyl-ester-on-brugia-pahangi-in-vitro-and-in-vivo
#17
Nazeh M Al-Abd, Zurainee Mohamed Nor, Quazim O Junaid, Marzida Mansor, M S Hasan, Mustafa Kassim
Lymphatic filariasis (LF) is a vector borne disease caused by parasitic worms such as Wuchereria bancrofti, Brugia malayi and B. timori, which are transmitted by mosquitoes. Current therapeutics to treat LF are mainly microfilarcidal, and lack activity against adult worms. This set back, poses a challenge for the control and elimination of filariasis. Thus, in this study the activities of caffeic acid phenethyl ester (CAPE) against the filarial worm B. pahangi and its bacterial endosymbiont, Wolbachia were evaluated...
October 25, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/29064364/translating-research-into-reality-elimination-of-lymphatic-filariasis-from-haiti
#18
Patrick J Lammie, Mark L Eberhard, David G Addiss, Kimberly Y Won, Madsen Beau de Rochars, Abdel N Direny, Marie Denise Milord, Jack Guy Lafontant, Thomas G Streit
Research provides the essential foundation of disease elimination programs, including the global program to eliminate lymphatic filariasis (GPELF). The development and validation of new diagnostic tools and intervention strategies, critical steps in the evolution of GPELF, required a global effort. Lymphatic filariasis research in Haiti involved many partners and was directly linked to the development of the national elimination program and to the success achieved to date. Ongoing research efforts involving many partners will continue to be important in resolving the challenges faced by the program today in its final efforts to achieve elimination...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29063617/ivermectin-and-its-target-molecules-shared-and-unique-modulation-mechanisms-of-ion-channels-and-receptors-by-ivermectin
#19
I-Shan Chen, Yoshihiro Kubo
Ivermectin (IVM) is an antiparasitic drug that is used worldwide and rescues hundreds of millions of people from onchocerciasis and lymphatic filariasis. It was discovered by Satoshi Ōmura and William C. Campbell, to whom the 2015 Nobel Prize in Physiology or Medicine was awarded. It kills parasites by activating glutamate-gated Cl(-) channels, and it also targets several ligand-gated ion channels and receptors, including Cys-loop receptors, P2X4 receptors and fernesoid X receptors. Recently, we found that IVM also activates a novel target, the G-protein-gated inwardly rectifying K(+) channel, and also identified the structural determinant for the activation...
October 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29062192/hydrophilic-nanosilica-as-a-new-larvicidal-and-molluscicidal-agent-for-controlling-of-major-infectious-diseases-in-egypt
#20
Marwa M Attia, Soliman M Soliman, Mahmoud A Khalf
AIM: This research was conducted to evaluate the molluscicidal and mosquitocidal efficacy of silica nanoparticles in the eradication of the larvae and pupa of malaria and filariasis vector as well as vectors of rift-valley fever virus (Culex pipiens); Schistosoma mansoni vector and Biomphlaria alexandrina (snail and egg masses). MATERIALS AND METHODS: Hydrophilic nanosilica particles (NSPs) were characterized using transmission electron microscope during the preliminary part of the study; the stages were exposed to upgrade concentrations of NSP from 50 to 1200 ppm each for 24-36 h exposure time...
September 2017: Veterinary World
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