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https://www.readbyqxmd.com/read/28904727/post-ivermectin-encephalopathy-in-senegal-a-case-report
#1
Daniel Gams Massi, Mohamed Lelouma Mansare, Mariétou Traoré, Moustapha Ndiaye, Amadou Gallo Diop, Mouhamadou Mansour Ndiaye
Ivermectin is an ant parasitic drug used for combating onchocerciasis and lymphatic filariasis. It works by inhibiting the function of neurons and muscles, thus causing paralysis of microfilariae. Side effects of this drug have been reported including post-ivermectin encephalopathy requiring emergency care in hospital. We report the case of a 35 years old patient living in rural areas of Senegal who presented two days after a mistake in administration of a second dose of ivermectin, headaches, altered consciousness and bilateral blindness...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28892473/a-multi-center-field-study-of-two-point-of-care-tests-for-circulating-wuchereria-bancrofti-antigenemia-in-africa
#2
Cédric B Chesnais, Naomi-Pitchouna Awaca-Uvon, Fatoma K Bolay, Michel Boussinesq, Peter U Fischer, Lincoln Gankpala, Aboulaye Meite, François Missamou, Sébastien D Pion, Gary J Weil
BACKGROUND: The Global Programme to Eliminate Lymphatic Filariasis uses point-of-care tests for circulating filarial antigenemia (CFA) to map endemic areas and for monitoring and evaluating the success of mass drug administration (MDA) programs. We compared the performance of the reference BinaxNOW Filariasis card test (ICT, introduced in 1997) with the Alere Filariasis Test Strip (FTS, introduced in 2013) in 5 endemic study sites in Africa. METHODOLOGY: The tests were compared prior to MDA in two study sites (Congo and Côte d'Ivoire) and in three sites that had received MDA (DRC and 2 sites in Liberia)...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28891597/12-month-longitudinal-parasitological-assessment-of-lymphatic-filariasis-positive-individuals-impact-of-bi-annual-treatment-with-ivermectin-and-albendazole
#3
John N Kanamitie, Collins S Ahorlu, Joseph Otchere, Fred Aboagye-Antwi, Bethel Kwansa-Bentum, Daniel A Boakye, Nana-Kwadwo Biritwum, Michael D Wilson, Dziedzom K de Souza
OBJECTIVE: Mass drug Administration (MDA) for the control of Lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections, and formulatingn appropriate strategies to control LF in these areas of persistent transmission. MATERIALS AND METHODS: In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana...
September 11, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28882174/molecular-phylogeny-of-anopheles-hyrcanus-group-members-based-on-its2-rdna
#4
Yuan Fang, Wen-Qi Shi, Yi Zhang
BACKGROUND: The Anopheles hyrcanus group includes 25 species, and is widely distributed in the Oriental and Palaearctic regions. Several species within this group are vectors of malaria, lymphatic filariasis and Japanese encephalitis. It is difficult or impossible to identify cryptic species based on their morphological characteristics, with some closely related species of the Hyrcanus Group have similar adult morphological characteristics. Thus, their molecular identification has been an important complementary method to traditional morphological taxonomy...
September 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28878429/the-national-programme-to-eliminate-lymphatic-filariasis-from-ethiopia
#5
Belete Mengistu, Kebede Deribe, Fikreab Kebede, Sarah Martindale, Mohammed Hassan, Heven Sime, Charles Mackenzie, Abate Mulugeta, Mossie Tamiru, Mesfin Sileshi, Asrat Hailu, Teshome Gebre, Amha Fentaye, Biruck Kebede
Lymphatic filariasis (LF) is one of the most debilitating and disfiguring diseases common in Ethiopia and is caused by Wuchereria bancrofti. Mapping for LF has shown that 70 woredas (districts) are endemic and 5.9 million people are estimated to be at risk. The national government's LF elimination programme commenced in 2009 in 5 districts integrated with the onchocerciasis programme. The programme developed gradually and has shown significant progress over the past 6 years, reaching 100% geographical coverage for mass drug administration (MDA) by 2016...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28874207/evaluation-of-active-ingredients-and-larvicidal-activity-of-clove-and-cinnamon-essential-oils-against-anopheles-gambiae-sensu-lato
#6
Adelina Thomas, Humphrey D Mazigo, Alphaxard Manjurano, Domenica Morona, Eliningaya J Kweka
BACKGROUND: Mosquitoes are well-known vectors of many diseases including malaria and lymphatic filariasis. Uses of synthetic insecticides are associated with high toxicity, resistance, environmental pollution and limited alternative, effective synthetic insecticides. This study was undertaken to evaluate the larvicidal efficacy of clove and cinnamon essential oils against laboratory Anopheles gambiae (sensu stricto) and wild An. arabiensis larvae. METHODS: The standard WHO guideline for larvicides evaluation was used, and the GC-MS machine was used for active compounds percentage composition analysis and structures identification...
September 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28869696/comparison-and-functional-characterization-of-peripheral-blood-mononuclear-cells-isolated-from-filarial-lymphedema-and-endemic-normals-of-a-south-indian-population
#7
Abel Arul Nathan, Madhulika Dixit, Subash Babu, Anand Setty Balakrishnan
OBJECTIVE: The underlying problem in lymphatic filariasis is irreversible swelling of the limbs (lymphedema), which is a unique feature of lymphatic insufficiency. It is still unclear whether the natural ability of lymphatics to form functional lymphatic vasculature is achieved or attenuated in the lymphedemal pathology. Clinical studies have clearly shown that circulating lymphatic progenitors (CLPs), a subset of bone-marrow derived mononuclear cells (PBMCs), contribute to post-natal lymph vasculogenesis...
September 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28867846/integrated-morbidity-management-for-lymphatic-filariasis-and-podoconiosis-ethiopia
#8
Kebede Deribe, Biruck Kebede, Mossie Tamiru, Belete Mengistu, Fikreab Kebede, Sarah Martindale, Heven Sime, Abate Mulugeta, Biruk Kebede, Mesfin Sileshi, Asrat Mengiste, Scott McPherson, Amha Fentaye
PROBLEM: Lymphatic filariasis and podoconiosis are the major causes of tropical lymphoedema in Ethiopia. The diseases require a similar provision of care, but until recently the Ethiopian health system did not integrate the morbidity management. APPROACH: To establish health-care services for integrated lymphoedema morbidity management, the health ministry and partners used existing governmental structures. Integrated disease mapping was done in 659 out of the 817 districts, to identify endemic districts...
September 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28862791/efficacy-of-the-volatile-oil-from-water-celery-helosciadium-nodiflorum-apiaceae-against-the-filariasis-vector-culex-quinquefasciatus-the-housefly-musca-domestica-and-the-african-cotton-leafworm-spodoptera-littoralis
#9
Giovanni Benelli, Roman Pavela, Massimo Ricciutelli, Giulio Lupidi, Filippo Maggi
Water celery (Helosciadium nodiflorum, Apiaceae), is a common and invasive hydrophyte occurring in rivers and slow waters of Europe. In the past, it was consumed as a vegetable and spices, but currently it has mostly been abandoned. As a result, this plant produces an unexploited biomass occluding rivers and slow waters. With the aim to valorise water celery as an important biomass source for the development of botanical insecticides, in this work we investigated the inhibitory effects of the essential oil hydro-distilled from its aerial parts against larvae of the filariasis vector Culex quinquefasciatus, adults of the housefly Musca domestica, and larvae of the African cotton leafworm Spodoptera littoralis...
September 1, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28859850/il-4-5-signalling-plays-an-important-role-during-litomosoides-sigmodontis-infection-influencing-both-immune-system-regulation-and-tissue-pathology-in-the-thoracic-cavity
#10
Manuel Ritter, Ruth S Tamadaho, Judith Feid, Wenzel Vogel, Katharina Wiszniewsky, Sven Perner, Achim Hoerauf, Laura E Layland
Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune responses and pathology development, and thus the rodent model of Litomosoides sigmodontis can be used to unravel host-filaria interactions...
August 30, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28835430/filarial-breast-lump
#11
Dwijesh Kumar Panda, Devi Prasad Mohapatra, Madhusmita Mohanty Mohapatra
Lymphatic filariasis is one of the most debilitating and disfiguring scourges among all diseases. This report presents a case of a woman with recurrent breast nodularity after being previously operated for a suspected breast neoplasm. We would like to highlight the issue of similar clinical presentation of a filarial breast lump and other breast lesions leading to inappropriate therapy.
August 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28833498/generation-and-selection-of-na%C3%A3-ve-fab-library-for-parasitic-antigen-anti-bmsxp-antibodies-for-lymphatic-filariasis
#12
Noorsharmimi Omar, Nurul Hamizah Hamidon, Muhammad Hafiznur Yunus, Rahmah Noordin, Yee Siew Choong, Theam Soon Lim
Phage display has been applied successfully as a tool for the generation of monoclonal antibodies (mAbs). Naive antibody libraries are unique as they are able to overcome several limitations associated with conventional mAb generation methods like the hybridoma technology. Here, we performed an in vitro selection and generation of Fab antibodies against Brugia malayi SXP protein (BmSXP), a recombinant antigen for the detection of lymphatic filariasis. We developed a naïve multi ethnic Fab antibody library with an estimated diversity of 2...
August 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28828575/improving-the-efficacy-of-a-prophylactic-vaccine-formulation-against-lymphatic-filariasis
#13
Nikhil Chauhan, Priyankana Banerjee, Vishal K Khatri, Andrew Canciamille, Jessica Gilles, Ramaswamy Kalyanasundaram
Mass drug administration (MDA) is the current strategy for interrupting the transmission of lymphatic filariasis (LF) infection and control of the disease in endemic areas. However, subject non-compliance has resulted in the presence of several "transmission hotspots" in the endemic regions threatening the reemergence of LF. This situation is further complicated by the fact that the drugs used in MDA are not effective against adult LF worms, a major concern for the control strategy. Thus, there is clearly a need for an effective and sustainable approach to control LF...
August 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28828375/community-based-field-implementation-scenarios-of-a-short-message-service-reporting-tool-for-lymphatic-filariasis-case-estimates-in-africa-and-asia
#14
Hayley E Mableson, Sarah Martindale, Michelle C Stanton, Charles Mackenzie, Louise A Kelly-Hope
BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease (NTD) targeted for global elimination by 2020. Currently there is considerable international effort to scale-up morbidity management activities in endemic countries, however there remains a need for rapid, cost-effective methods and adaptable tools for obtaining estimates of people presenting with clinical manifestations of LF, namely lymphoedema and hydrocele. The mHealth tool 'MeasureSMS-Morbidity' allows health workers in endemic areas to use their own mobile phones to send clinical information in a simple format using short message service (SMS)...
2017: MHealth
https://www.readbyqxmd.com/read/28827998/molecular-cloning-and-characterization-of-protein-disulfide-isomerase-of-brugia-malayi-a-human-lymphatic-filarial-parasite
#15
Pravesh Verma, Pawan Kumar Doharey, Sunita Yadav, Ankur Omer, Poonam Singh, Jitendra Kumar Saxena
Lymphatic filariasis results in an altered lymphatic system and the abnormal enlargement of body parts, causing pain, serious disability and social stigma. Effective vaccines are still not available nowadays, drugs against the disease is required. Protein disulfide isomerase (PDI) is an essential catalyst of the endoplasmic reticulum which is involved in folding and chaperone activities in different biological systems. Here, we report the enzymatic characterization of a Brugia malayi Protein disulfide isomerase (BmPDI), which was expressed and purified from Escherichia coli BL21 (DE3)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28819487/an-evaluation-of-wb123-antibody-elisa-in-individuals-treated-with-ivermectin-and-albendazole-and-implementation-challenges-in-africa
#16
Dziedzom Komi de Souza, Irene Offei Owusu, Joseph Otchere, Michelle Adimazoya, Kwadwo Frempong, Collins Stephen Ahorlu, Daniel Adjei Boakye, Michael David Wilson
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818649/sequence-analysis-of-mtdna-coi-barcode-region-revealed-three-haplotypes-within-culex-pipiens-assemblage
#17
Mona Koosha, Mohammad Ali Oshaghi, Mohammad Mehdi Sedaghat, Hassan Vatandoost, Shahyad Azari-Hamidian, Mohammad Reza Abai, Ahmad Ali Hanafi-Bojd, Fatemeh Mohtarami
Members of the Culex (Culex) pipiens assemblage are known vectors of deadly encephalitides, periodic filariasis, and West Nile virus throughout the world. However, members of this assemblage are morphologically indistinguishable or hard to distinguish and play distinct roles in transmission of the diseases. The current study aimed to provide further evidence on utility of the two most popular nuclear (ITS2-rDNA) and mitochondrial (COI barcode region) genetic markers to identify members of the assemblage. Culex pipiens assemblage specimens from different climate zones of Iran were collected and identified to species level based on morphological characteristics...
August 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28814926/wuchereria-bancrofti-infection-at-four-primary-schools-and-surrounding-communities-with-no-previous-blood-surveys-in-northern-uganda-the-prevalence-after-mass-drug-administrations-and-a-report-on-suspected-non-filarial-endemic-elephantiasis
#18
Emmanuel Igwaro Odongo-Aginya, Alex Olia, Kilama Justin Luwa, Eiji Nagayasu, Anna Mary Auma, Geoffrey Egitat, Gerald Mwesigwa, Yoshitaka Ogino, Eisaku Kimura, Toshihiro Horii
BACKGROUND: A prevalence study of Wuchereria bancrofti infection was carried out in 2014 at 4 study sites in northern Uganda using antigen and microfilaria tests. Each study site consists of a primary school and surrounding communities. These sites are inside the filariasis endemic area and have been covered by mass drug administration under the national elimination programme. However, no prevalence study had been conducted there before the present study. Without information on past and present endemicity levels, our study was meant to be an independent third-party investigation to know the latest filariasis situation...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28811153/the-design-of-target-specific-antibodies-scfv-by-applying-de-novo-workflow-case-study-on-bmr1-antigen-from-brugia-malayi
#19
Bee Yin Khor, Theam Soon Lim, Rahmah Noordin, Yee Siew Choong
De novo approach was applied to design single chain fragment variable (scFv) for BmR1, a recombinant antigen from Bm17DIII gene which is the primary antigen used for the detection of anti-BmR1 IgG4 antibodies in the diagnostic of lymphatic filariasis. Three epitopes of the BmR1 was previously predicted form an ab initio derived three-dimensional structure. A collection of energetically favourable conformations was generated via hot-spot-centric approach. This resulted in a set of three different scFv scaffolds used to compute the high shape complementary conformations via dock-and-design approach with the predicted epitopes of BmR1...
July 19, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28804661/imported-asymptomatic-bancroftian-filariasis-discovered-from-a-plasmodium-vivax-infected-patient-a-case-report-from-singapore
#20
Jean-Marc Chavatte, Roland Jureen
Human lymphatic filariasis is a vector-borne disease mainly caused by the parasitic nematode Wuchereria bancrofti and transmitted worldwide within the tropical and subtropical regions. Singapore was once endemic for bancroftian filariasis but recent reports are scarce and the disease is nearly forgotten. The case report presented here reports the incidental hospital laboratory finding of an asymptomatic microfilaremia in a relapsing Plasmodium vivax imported case during a malaria treatment follow-up appointment...
2017: Case Reports in Infectious Diseases
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