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https://www.readbyqxmd.com/read/29348597/author-correction-short-course-high-dose-rifampicin-achieves-wolbachia-depletion-predictive-of-curative-outcomes-in-preclinical-models-of-lymphatic-filariasis-and-onchocerciasis
#1
Ghaith Aljayyoussi, Hayley E Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A N Cook, Andrew Steven, Raman Sharma, Ana F Guimaraes, Rachel H Clare, Andrew Cassidy, Kelly L Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D Turner, Mark J Taylor, Stephen A Ward
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334340/identification-of-anti-filarial-leads-against-aspartate-semialdehyde-dehydrogenase-of-wolbachia-endosymbiont-of-brugia-malayi-combined-molecular-docking-and-molecular-dynamics-approaches
#2
Dhamodharan Prabhu, Sundaraj Rajamanikandan, Mathimaran Amala, Surekha Kanagarajan, Jeyaraman Jeyakanthan
Lymphatic filariasis is a debilitating vector borne parasitic disease that infects human lymphatic system by nematode Brugia malayi. Currently available anti-filarial drugs are effective only on the larval stages of parasite. So far, no effective drugs are available for humans to treat filarial infections. In this regard, aspartate semialdehyde dehydrogenase (ASDase) in lysine biosynthetic pathway from Wolbachia endosymbiont Brugia malayi represents an attractive therapeutic target for the development of novel anti-filarial agents...
January 15, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29331268/the-population-biology-and-transmission-dynamics-of-loa-loa
#3
REVIEW
Charles Whittaker, Martin Walker, Sébastien D S Pion, Cédric B Chesnais, Michel Boussinesq, María-Gloria Basáñez
Endemic to Central Africa, loiasis - or African eye worm (caused by the filarial nematode Loa loa) - affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public health relevance because it impedes mass drug administration-based interventions against onchocerciasis and lymphatic filariasis in co-endemic areas. Recent research has challenged this conception, demonstrating excess mortality associated with high levels of infection, implying that loiasis warrants attention as an intrinsic public health problem...
January 10, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29330277/bancroftian-filariasis-associated-with-male-sterility
#4
Dwijesh Kumar Panda, Devi Prasad Mohapatra
No abstract text is available yet for this article.
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29324858/mapping-the-geographical-distribution-of-podoconiosis-in-cameroon-using-parasitological-serological-and-clinical-evidence-to-exclude-other-causes-of-lymphedema
#5
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29318998/travel-related-parasitic-infections-in-travellers-to-southeast-asia-and-western-pacific-countries
#6
Eylem Akdur Öztürk, Ayşegül Ünver
In the last decades, there has been a significant increase in international human mobility with increase in the prosperity, travel possibilities, and number of refugees. In the first half of 2016, the Asian continent showed the fastest growth in the number of tourists. Such increase is seen due to the interest in Asian history, culture, and cuisine. In the globalizing world, human mobility causes changes in the epidemiology of diseases and the spread of various infections across continents. Parasitic infections that may pose a risk for travellers to the Asia-Pacific are malaria, leishmaniasis, filariasis, foodborne trematode infections, schistosomiasis, soil-transmitted infections, and tourist diarrhea...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29310700/a-cross-sectional-study-of-the-filarial-and-leishmania-co-endemicity-in-two-ecologically-distinct-settings-in-mali
#7
Moussa Brema Sangare, Yaya Ibrahim Coulibaly, Siaka Yamoussa Coulibaly, Michel Emmanuel Coulibaly, Bourama Traore, Ilo Dicko, Ibrahim Moussa Sissoko, Sibiry Samake, Sekou Fantamady Traore, Thomas Bruce Nutman, Jesus Gilberto Valenzuela, Ousmane Faye, Shaden Kamhawi, Fabiano Oliveira, Roshanak Tolouei Semnani, Seydou Doumbia
BACKGROUND: Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) and Leishmania major parasites in two ecologically distinct areas of Mali, the Kolokani district (villages of Tieneguebougou and Bougoudiana) in North Sudan Savanna area, and the district of Kolondieba (village of Boundioba) in the South Sudan Savanna area...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29310051/lc-ms-ms-method-for-simultaneous-determination-of-diethylcarbamazine-albendazole-and-albendazole-metabolites-in-human-plasma-application-to-a-clinical-pharmacokinetic-study
#8
Yashpal S Chhonker, Constant Edi, Daryl J Murry
Combination therapy with anti-filarial drugs is now widely used for treatment of lymphatic filariasis. A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous quantitation of diethylcarbamazine (DEC), albendazole (ABZ) and albendazole metabolites in human plasma. Separation and detection of analytes were achieved on a reversed phase column (Acquity UPLC®BEH C18 column (100 × 2.1 mm, 1.7 μm) with gradient elution using 0...
December 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29308790/corrigendum-minocycline-as-a-re-purposed-anti-wolbachia-macrofilaricide-superiority-compared-with-doxycycline-regimens-in-a-murine-infection-model-of-human-lymphatic-filariasis
#9
Raman Sharma, Ghaith Aljayyoussi, Hayley E Tyrer, Joanne Gamble, Laura Hayward, Ana F Guimaraes, Jill Davies, David Waterhouse, Darren A N Cook, Laura J Myhill, Rachel H Clare, Andrew Cassidy, Andrew Steven, Kelly L Johnston, Louise Ford, Joseph D Turner, Stephen A Ward, Mark J Taylor
This corrects the article DOI: 10.1038/srep23458.
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29300732/combinations-of-registered-drugs-reduce-treatment-times-required-to-deplete-wolbachia-in-the-litomosoides-sigmodontis-mouse-model
#10
Sabine Specht, Kenneth M Pfarr, Sandra Arriens, Marc P Hübner, Ute Klarmann-Schulz, Marianne Koschel, Sonja Sternberg, Coralie Martin, Louise Ford, Mark J Taylor, Achim Hoerauf
Filarial parasites can be targeted by antibiotic treatment due to their unique endosymbiotic relationship with Wolbachia bacteria. This finding has led to successful treatment strategies in both, human onchocerciasis and lymphatic filariasis. A 4-6 week treatment course using doxycycline results in long-term sterility and safe macrofilaricidal activity in humans. However, current treatment times and doxycycline contraindications in children and pregnant women preclude widespread administration of doxycycline in public health control programs; therefore, the search for shorter anti-wolbachial regimens is a focus of ongoing research...
January 4, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29289559/geographical-distribution-and-species-identification-of-human-filariasis-and-onchocerciasis-in-bioko-island-equatorial-guinea
#11
Thuy-Huong Ta, Laura Moya, Justino Nguema, Pilar Aparicio, María Miguel Oteo, Gema Cenzual, Isabel Canorea, Marta Lanza, Agustín Benito, James Lee Crainey, José Miguel Rubio
Human filariae are vector-borne parasites and the causative agents of various diseases, including human onchocerciasis and lymphatic filariasis. Onchocerciasis causes a spectrum of cutaneous and ophthalmologic manifestations (including blindness) and has long been a major public health problem in Bioko Island (Equatorial Guinea). Bioko Island has been included in the WHO's Onchocerciasis Control Program since 1987. In Bioko Island, the specificity and sensitivity of clinical Onchocerca volvulus diagnosis is key...
December 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29259652/cytomorphological-spectrum-of-epididymal-nodules-an-institution-s-experience
#12
Jyotsna Naresh Bharti, Biswajit Dey, Jenna Bhattacharya, Shyama Jain
Background: Epididymal lesions are uncommon in clinical practice. Few case series has been described in the literature documenting the role of cytology in the evaluation of epididymal nodules. This study was undertaken to analyze the cytomorphology of epididymal nodules and to evaluate role of fine-needle aspiration biopsy (FNAB) in early definitive diagnosis of epididymal nodules. Materials and Methods: A total of seventy cases of epididymal nodules were aspirated over a period of 6 years in the Department of Pathology...
2017: CytoJournal
https://www.readbyqxmd.com/read/29250727/green-synthesis-of-silver-nanoparticles-using-holarrhena-antidysenterica-l-wall-bark-extract-and-their-larvicidal-activity-against-dengue-and-filariasis-vectors
#13
Dinesh Kumar, Gaurav Kumar, Veena Agrawal
The present study was carried out to evaluate the larvicidal potential of methanol, hexane, acetone, chloroform, and aqueous bark extracts of Holarrhena antidysenterica (L.) Wall. and silver nanoparticles (AgNPs) synthesized using aqueous bark extract against the third instar larvae of Aedes aegypti L. and Culex quinquefasciatus Say. AgNPs were prepared by adding 10 ml of aqueous bark extract in 90 ml of 1 mM silver nitrate (AgNO3) solution. After 5 min of mixing, a change in color from yellow to dark brown occurred indicating the synthesis of AgNPs...
December 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29234183/lymph-node-enlargement-in-neck-filariasis-as-a-rare-cause-a-case-report
#14
Rindu Raveendran
Lymphatic filariasis is endemic to tropical countries and is the most common cause of acquired lymphedema in the world. Wuchereria bancrofti is the main etiological agent responsible. While the presentation of filariasis in limbs is common, isolated presentation as a single enlarged lymph node in the neck is very rare. We describe a 48-year-old Indian woman, who presented with a hard lymph node in the neck. There was no other significant lymph node enlargement. The overlying skin was erythematous, and no other findings were present on examination...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29227197/moderating-factors-in-tissue-tonometry-and-bioimpedance-spectroscopy-measures-in-the-lower-extremity-of-healthy-young-people-in-australia-and-myanmar
#15
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Expected values for tissue tonometry and bioimpedance spectroscopy (BIS) in the lower extremity of young people have not been established. These measures are commonly used to assess tissue changes in adult, breast cancer-related lymphedema of the arm. In tropical regions, identification of tissue changes in the lower limbs related to lymphatic filariasis is required; hence expected values and factors contributing to variation in tissue tonometry and BIS in two tropical populations were investigated...
December 11, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29225962/tlr-specific-immune-responses-against-helminth-infections
#16
REVIEW
Sivaprakasam Rajasekaran, Rajamanickam Anuradha, Ramalingam Bethunaickan
Despite marked improvement in the quality of lives across the globe, more than 2 million individuals in socioeconomically disadvantaged environments remain infected by helminth (worm) parasites. Owing to the longevity of the worms and paucity of immunologic controls, these parasites survive for long periods within the bloodstream, lymphatics, and gastrointestinal tract resulting in pathologic conditions such as anemia, cirrhosis, and lymphatic filariasis. Despite infection, an asymptomatic state may be maintained by the host immunoregulatory environment, which involves multiple levels of regulatory cells and cytokines; a breakdown of this regulation is observed in pathological disease...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29224979/perceptions-knowledge-attitudes-and-practices-for-the-prevention-and-control-of-lymphatic-filariasis-in-conakry-republic-of-guinea
#17
Bernard L Kouassi, Aboulaye Barry, Kathrin Heitz-Tokpa, Stefanie J Krauth, Andre Goépogui, Mamadou S Baldé, Oumar Barry, Marie L Niamey, Moses J Bockarie, Benjamin G Koudou, Jürg Utzinger
Little is known about the perceptions, attitudes and practices of lymphatic filariasis in Conakry, Republic of Guinea. Yet, such knowledge is important for an optimal design and implementation of setting-specific prevention and control measures. We conducted a cross-sectional study using a mixed methods approach. Qualitative data related to people's general experience with lymphatic filariasis, their perception of the causes of the disease, the onset of elephantiasis, care-seeking behaviour and the socioeconomic impact of lymphatic filariasis were collected by in-depth interviews with 85 respondents...
December 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29211746/review-of-the-factors-influencing-the-motivation-of-community-drug-distributors-towards-the-control-and-elimination-of-neglected-tropical-diseases-ntds
#18
Alison Krentel, Margaret Gyapong, Shruti Mallya, Nana Yaa Boadu, Mary Amuyunzu-Nyamongo, Mariana Stephens, Deborah A McFarland
BACKGROUND: Community drug distributors or neglected tropical disease (NTD) volunteers have played a crucial role in ensuring the success of mass drug administration (MDA) programs using preventive chemotherapy (PC) for lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and soil transmitted helminths. In recent years however, a noticeable decline in motivation of some of these volunteers has been perceived, potentially negatively impacting the success of these programs. Potential hypotheses for this change in motivation include the long duration of many MDA programs, the change in sociocultural environments as well as the changes to the programs over time...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29206992/seroprevalence-of-lymphatic-filariasis-among-migrant-workers-in-peninsular-malaysia
#19
Rahmah Noordin, Siti Nursheena Mohd Zain, Muhammad Hafiznur Yunus, Norhidayu Sahimin
Background: Malaysia aims to eliminate lymphatic filariasis (LF) by the year 2020, thus the potential threat of LF from migrant workers needs to be investigated. Methods: Brugian and bancroftian filariasis among 484 migrant workers from six countries were investigated using rapid tests based on detection of specific IgG4 antibodies against BmR1 (Brugia Rapid) and BmSXP recombinant antigens. Results: The seroprevalence of brugian filariasis was very low; however, bancroftian filariasis was notable among workers from India, Nepal and Myanmar...
December 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29202080/a-practical-approach-for-scaling-up-the-alternative-strategy-for-the-elimination-of-lymphatic-filariasis-in-loa-loa-endemic-countries-developing-an-action-plan
#20
Louise A Kelly-Hope, Michelle C Stanton, Honorat G M Zouré, Boniface E Kinvi, Alexei Mikhailov, Afework Tekle, Jonathan D King
Background: Lymphatic filariasis (LF) is a vector-borne parasitic disease that is being targeted for elimination through mass drug administration (MDA). The co-distribution of Loa loa in Central Africa poses a significant barrier to the expansion of the MDA due to risk of severe adverse events (SAEs) associated with the drug ivermectin that is routinely used. National LF programmes are yet to significantly scale up in co-endemic areas and need a practical approach to make preliminary decisions based on the mapping status and potential treatment strategies...
2017: Global Health Research and Policy
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