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https://www.readbyqxmd.com/read/28532397/a-systematic-review-of-factors-that-shape-implementation-of-mass-drug-administration-for-lymphatic-filariasis-in-sub-saharan-africa
#1
Adam Silumbwe, Joseph Mumba Zulu, Hikabasa Halwindi, Choolwe Jacobs, Jessy Zgambo, Rosalia Dambe, Mumbi Chola, Gershom Chongwe, Charles Michelo
BACKGROUND: Understanding factors surrounding the implementation process of mass drug administration for lymphatic filariasis (MDA for LF) elimination programmes is critical for successful implementation of similar interventions. The sub-Saharan Africa (SSA) region records the second highest prevalence of the disease and subsequently several countries have initiated and implemented MDA for LF. Systematic reviews have largely focused on factors that affect coverage and compliance, with less attention on the implementation of MDA for LF activities...
May 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28527817/lymphatic-filariasis-elimination-efforts-in-rufiji-south-eastern-tanzania-decline-in-circulating-filarial-antigen-prevalence-in-young-school-children-after-twelve-rounds-of-mass-drug-administration-and-utilization-of-long-lasting-insecticide-treated-nets
#2
Clarer Jones, Billy Ngasalla, Yahya A Derua, Donath Tarimo, Mwelecele N Malecela
BACKGROUND: Lymphatic filariasis (LF) is a parasitic infection transmitted by mosquito vectors and in sub Saharan Africa it is caused by nematode Wuchereria bancrofti. The disease has been targeted for global elimination by using annual mass drug administration (MDA) strategy. On the other hand, vector control is known to play important complementary role to the MDAs in reducing LF transmission. We report the findings of the effect of MDA and ITNs intervention implemented in endemic area of south-eastern Tanzania METHODS: A cross-sectional study for W...
May 17, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28525982/blood-meal-induced-regulation-of-the-chemosensory-gene-repertoire-in-the-southern-house-mosquito
#3
Tanvi Taparia, Rickard Ignell, Sharon Rose Hill
BACKGROUND: The southern house mosquito, Culex quinquefasciatus, is one of the most prevalent vectors of lymphatic filariasis and flavivirus-induced encephalitis. Its vectorial capacity is directly affected by its reproductive feeding behaviors, such as host seeking, blood feeding, resting, and egg laying. In mosquitoes, these gonotrophic behaviors are odor-mediated and regulated following blood feeding. Immediately after a blood meal, female mosquitoes show reduced olfactory responsiveness and flight activity, as they enter a resting state...
May 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28507911/filariasis-orchitis-differential-for-acute-scrotum-pathology
#4
Karmon M Janssen, Cornelia J Willis, Mark Anderson, Mary S Gelnett, Emily L Wickersham, Timothy C Brand
Granulomatous Orchitis secondary to lymphatic filiarisis is a rare diagnosis within the United States. We report a case of a 22yo Male from Sri Lanka, with a new onset scrotal swelling and palpable right testicular mass. Ultrasound identified a 1 cm right testicular mass with signs of tunica albuginea invasion. A right inguinal radical orchiectomy was performed and pathology showed Filarial orchitis. This report describes the detailed history, physical exam, and diagnostic workup and treatment options for a rare entity for acute scrotal pathology...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28505314/diversity-of-mosquitoes-diptera-culicidae-attracted-to-human-subjects-in-rubber-plantations-secondary-forests-and-villages-in-luang-prabang-province-northern-lao-pdr
#5
Julie-Anne A Tangena, Phoutmany Thammavong, Naritsara Malaithong, Thavone Inthavong, Phuthasone Ouanesamon, Paul T Brey, Steve W Lindsay
The impact of the rapid expansion of rubber plantations in South-East Asia on mosquito populations is uncertain. We compared the abundance and diversity of adult mosquitoes using human-baited traps in four typical rural habitats in northern Lao PDR: secondary forests, immature rubber plantations, mature rubber plantations, and villages. Generalized estimating equations were used to explore differences in mosquito abundance between habitats, and Simpson's diversity index was used to measure species diversity...
May 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28493966/improving-drug-delivery-strategies-for-lymphatic-filariasis-elimination-in-urban-areas-in-ghana
#6
Nana-Kwadwo Biritwum, Bertha Garshong, Bright Alomatu, Dziedzom K de Souza, Margaret Gyapong, Dominique Kyelem
The Global Program to Eliminate Lymphatic Filariasis (GPELF) advocates for the treatment of entire endemic communities, in order to achieve its elimination targets. LF is predominantly a rural disease, and achieving the required treatment coverage in these areas is much easier compared to urban areas that are more complex. In Ghana, parts of the Greater Accra Region with Accra as the capital city are also endemic for LF. Mass Drug Administration (MDA) in Accra started in 2006. However, after four years of treatment, the coverage has always been far below the 65% epidemiologic coverage for interrupting transmission...
May 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28486498/migratory-phase-of-litomosoides-sigmodontis-filarial-infective-larvae-is-associated-with-pathology-and-transient-increase-of-s100a9-expressing-neutrophils-in-the-lung
#7
Gregory Karadjian, Frédéric Fercoq, Nicolas Pionnier, Nathaly Vallarino-Lhermitte, Emilie Lefoulon, Adélaïde Nieguitsila, Sabine Specht, Leo M Carlin, Coralie Martin
Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in humans and L. sigmodontis, a well-established model of filariasis in mice. L. sigmodontis L3 migrate to the pleural cavity where they moult into L4 around day 9 and into male and female adult worms around day 30. Little is known of the early phase of the parasite life cycle, after the L3 is inoculated in the dermis by the vector and enters the afferent lymphatic vessels and before the moulting processes in the pleural cavity...
May 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28481947/brugia-malayi-microfilariae-adhere-to-human-vascular-endothelial-cells-in-a-c3-dependent-manner
#8
Jan-Hendrik Schroeder, David McCarthy, Tadge Szestak, Darren A Cook, Mark J Taylor, Alister G Craig, Charlotte Lawson, Rachel A Lawrence
Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance in the peripheral blood follows a circadian periodicity and reaches a peak when the mosquito is most likely to feed. For the remaining hours, the majority of Mf sequester in the lung capillaries. This circadian phenomenon has been widely reported and is likely to maximise parasite fitness and optimise transmission potential...
May 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28459012/stage-specific-antibody-response-against-two-larval-stages-of-brugia-malayi-in-different-clinical-spectra-of-brugian-filariasis
#9
Praveen Kumar Tripathi, Ramesh Chander Mahajan, Nancy Malla, Naveen Kumar, Shailja Misra Bhattacharya, Ranganatha Krishna Shinoy, Abhishek Mewara, Rakesh Sehgal
CONTEXT: T-cell hypo-responsiveness in microfilaria (Mf) carriers against the microfilarial stage antigen of Brugia malayi has been described, but no study has been carried out to assess antibody dynamics against stage-specific antigens. AIM: The work was carried out with the aim to assess stage-specific antibody responses against L3 and microfilarial stage antigens in brugian filariasis in an endemic area. SETTING AND DESIGN: Patients with different clinical spectra of brugian filariasis were recruited to evaluate antibody responses to brugian antigens...
January 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/28458073/community-directed-mass-drug-administration-is-undermined-by-status-seeking-in-friendship-networks-and-inadequate-trust-in-health-advice-networks
#10
Goylette F Chami, Andreas A Kontoleon, Erwin Bulte, Alan Fenwick, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Over 1.9 billion individuals require preventive chemotherapy through mass drug administration (MDA). Community-directed MDA relies on volunteer community medicine distributors (CMDs) and their achievement of high coverage and compliance. Yet, it is unknown if village social networks influence effective MDA implementation by CMDs. In Mayuge District, Uganda, census-style surveys were conducted for 16,357 individuals from 3,491 households in 17 villages. Praziquantel, albendazole, and ivermectin were administered for one month in community-directed MDA to treat Schistosoma mansoni, hookworm, and lymphatic filariasis...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28457226/commentary-restarting-ntd-programme-activities-after-the-ebola-outbreak-in-liberia
#11
Brent C Thomas, Karsor Kollie, Benjamin Koudou, Charles Mackenzie
It is widely known that the recent Ebola Virus Disease (EVD) in West Africa caused a serious disruption to the national health system, with many of ongoing disease focused programmes, such as mass drug administration (MDA) for onchocerciasis (ONC), lymphatic filariasis (LF) and schistosomiasis (SCH), being suspended or scaled-down. As these MDA programmes attempt to restart post-EVD it is important to understand the challenges that may be encountered. This commentary addresses the opinions of the major health sectors involved, as well as those of community members, regarding logistic needs and challenges faced as these important public health programmes consider restarting...
May 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28453850/a-novel-ligand-of-toll-like-receptor-4-from-the-sheath-of-wuchereria-bancrofti-microfilaria-induces-proinflammatory-response-in-macrophages
#12
Suprabhat Mukherjee, Sandip Mukherjee, Tushar K Maiti, Samir Bhattacharya, Santi P Sinha Babu
Background.: Lymphatic filariasis, frequently caused from Wuchereria bancrofti infection, is endemic in several parts of the globe and responsible for human health problems and socioeconomic loss to a large extent. Inflammatory consequences originating from host-parasite interaction play a major role in the disease pathology and allied complications. The identity of the key mediator of this process is yet unknown in filarial research. Methods.: Microfilarial protein (MfP) was isolated from the sheath of W...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28443941/knowledge-attitudes-and-perceptions-regarding-lymphatic-filariasis-study-on-systematic-noncompliance-with-mass-drug-administration
#13
Silvia Cabral, Cristine Bonfim, Rosalira Oliveira, Paula Oliveira, Terezinha Guimarães, Eduardo Brandão, Ana Maria Aguiar-Santos, Zulma Medeiros
The aim of this study was to investigate the epidemiological characteristics, antigenic profile, perceptions, attitudes and practices of individuals who have been systematically non-compliant in mass drug administration (MDA) campaigns targeting lymphatic filariasis, in the municipality of Olinda, State of Pernambuco, Northeastern Brazil. A pretested questionnaire was used to obtain information on socioenvironmental demographics, perceptions of lymphatic filariasis and MDA, and reasons for systematic noncompliance with treatment...
April 20, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28434401/ivermectin-to-reduce-malaria-transmission-i-pharmacokinetic-and-pharmacodynamic-considerations-regarding-efficacy-and-safety
#14
REVIEW
Carlos Chaccour, Felix Hammann, N Regina Rabinovich
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28432603/immunoprophylaxis-of-multi-antigen-peptide-map-vaccine-for-human-lymphatic-filariasis
#15
Christiana Immanuel, Aparnaa Ramanathan, Malathi Balasubramaniyan, Vishal Kishor Khatri, Nitin Purushottam Amdare, Donthamsetty Nageswara Rao, Maryada Venkata Rami Reddy, Kaliraj Perumal
Human lymphatic filariasis, the parasitic disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, is ranked as the second most complex clinical condition leading to permanent and long-term disability. The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T and B cell epitopes as the constituents of a single immunogen. Here, we report on the design, chemical synthesis, and immunoprophylaxis of three epitopes that have been identified from promising vaccine candidates reported in our previous studies, constructed as MAP on an inert lysine core for human lymphatic filariasis in Jird model...
April 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28426656/the-role-of-omics-in-the-quest-to-eliminate-human-filariasis
#16
REVIEW
Sara Lustigman, Alexandra Grote, Elodie Ghedin
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28416397/monitoring-thermal-and-chemical-unfolding-of-brugia-malayi-calreticulin-using-fluorescence-and-circular-dichroism-spectroscopy
#17
Sunita Yadav, Smita Gupta, Jitendra Kumar Saxena
Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible for prevention of host classical complement pathway activation via its interaction with first component C1q of the human host. Therefore, BmCRT is an essential protein for parasite survival and an important drug target to fend filariasis. In the present study, we have carried out a systamatic biophysical characterization of BmCRT protein. Unfolding of BmCRT was found to be non-cooperative two-state process in the presence of both denaturant GdmCl and urea...
April 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28415554/phytosynthesis-of-silver-nanoparticles-using-aqueous-leaf-extracts-of-lippia-citriodora-antimicrobial-larvicidal-and-photocatalytic-evaluations
#18
Elias E Elemike, Damian C Onwudiwe, Anthony C Ekennia, Richard C Ehiri, Nnaemeka J Nnaji
Nanoscience and nanotechnology represent new and enabling platforms that promise to provide broad range of novel and improved technologies for environmental, biological and other scientific applications. This study reports the synthesis of silver nanoparticles mediated by aqueous leaf extract of Lippia citriodora at two different temperatures of 50°C and 90°C. The synthesis of colloidal silver nanoparticles (AgNPs) was monitored by the use of UV-visible spectroscopy at different temperatures and time intervals...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28406927/application-of-a-household-based-molecular-xenomonitoring-strategy-to-evaluate-the-lymphatic-filariasis-elimination-program-in-tamil-nadu-india
#19
Swaminathan Subramanian, Purushothaman Jambulingam, Brian K Chu, Candasamy Sadanandane, Venkatesan Vasuki, Adinarayanan Srividya, Mohamed S Mohideen AbdulKader, Kaliannagounder Krishnamoorthy, Harikishan K Raju, Sandra J Laney, Steven A Williams, Ralph H Henderson
BACKGROUND: The monitoring and evaluation of lymphatic filariasis (LF) has largely relied on the detection of antigenemia and antibodies in human populations. Molecular xenomonitoring (MX), the detection of parasite DNA/RNA in mosquitoes, may be an effective complementary method, particularly for detecting signals in low-level prevalence areas where Culex is the primary mosquito vector. This paper investigated the application of a household-based sampling method for MX in Tamil Nadu, India...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28388682/a-low-technology-emanator-treated-with-the-volatile-pyrethroid-transfluthrin-confers-long-term-protection-against-outdoor-biting-vectors-of-lymphatic-filariasis-arboviruses-and-malaria
#20
Sheila B Ogoma, Arnold S Mmando, Johnson K Swai, Sebastian Horstmann, David Malone, Gerry F Killeen
BACKGROUND: The vapor phase of the volatile pyrethroid transfluthrin incapacitates mosquitoes and prevents them from feeding. Although existing emanator products for delivering volatile pyrethroids protect against outdoor mosquito bites, they are too short-lived to be practical or affordable for routine use in low-income settings. New transfluthrin emanators, comprised simply of treated hessian fabric strips, have recently proven highly protective against outdoor-biting vectors of lymphatic filariasis, arboviruses and malaria, but their full protective lifespan, minimum dose requirements, and range of protection have not previously been assessed...
April 2017: PLoS Neglected Tropical Diseases
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