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https://www.readbyqxmd.com/read/28443941/knowledge-attitudes-and-perceptions-regarding-lymphatic-filariasis-study-on-systematic-noncompliance-with-mass-drug-administration
#1
Silvia Cabral, Cristine Bonfim, Rosalira Oliveira, Paula Oliveira, Terezinha Guimarães, Eduardo Brandão, Ana Maria Aguiar-Santos, Zulma Medeiros
The aim of this study was to investigate the epidemiological characteristics, antigenic profile, perceptions, attitudes and practices of individuals who have been systematically non-compliant in mass drug administration (MDA) campaigns targeting lymphatic filariasis, in the municipality of Olinda, State of Pernambuco, Northeastern Brazil. A pretested questionnaire was used to obtain information on socioenvironmental demographics, perceptions of lymphatic filariasis and MDA, and reasons for systematic noncompliance with treatment...
April 20, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28434401/ivermectin-to-reduce-malaria-transmission-i-pharmacokinetic-and-pharmacodynamic-considerations-regarding-efficacy-and-safety
#2
REVIEW
Carlos Chaccour, Felix Hammann, N Regina Rabinovich
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28432603/immunoprophylaxis-of-multi-antigen-peptide-map-vaccine-for-human-lymphatic-filariasis
#3
Christiana Immanuel, Aparnaa Ramanathan, Malathi Balasubramaniyan, Vishal Kishor Khatri, Nitin Purushottam Amdare, Donthamsetty Nageswara Rao, Maryada Venkata Rami Reddy, Kaliraj Perumal
Human lymphatic filariasis, the parasitic disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, is ranked as the second most complex clinical condition leading to permanent and long-term disability. The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T and B cell epitopes as the constituents of a single immunogen. Here, we report on the design, chemical synthesis, and immunoprophylaxis of three epitopes that have been identified from promising vaccine candidates reported in our previous studies, constructed as MAP on an inert lysine core for human lymphatic filariasis in Jird model...
April 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28426656/the-role-of-omics-in-the-quest-to-eliminate-human-filariasis
#4
REVIEW
Sara Lustigman, Alexandra Grote, Elodie Ghedin
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28416397/monitoring-thermal-and-chemical-unfolding-of-brugia-malayi-calreticulin-using-fluorescence-and-circular-dichroism-spectroscopy
#5
Sunita Yadav, Smita Gupta, Jitendra Kumar Saxena
Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible for prevention of host classical complement pathway activation via its interaction with first component C1q of the human host. Therefore, BmCRT is an essential protein for parasite survival and an important drug target to fend filariasis. In the present study, we have carried out a systamatic biophysical characterization of BmCRT protein. Unfolding of BmCRT was found to be non-cooperative two-state process in the presence of both denaturant GdmCl and urea...
April 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28415554/phytosynthesis-of-silver-nanoparticles-using-aqueous-leaf-extracts-of-lippia-citriodora-antimicrobial-larvicidal-and-photocatalytic-evaluations
#6
Elias E Elemike, Damian C Onwudiwe, Anthony C Ekennia, Richard C Ehiri, Nnaemeka J Nnaji
Nanoscience and nanotechnology represent new and enabling platforms that promise to provide broad range of novel and improved technologies for environmental, biological and other scientific applications. This study reports the synthesis of silver nanoparticles mediated by aqueous leaf extract of Lippia citriodora at two different temperatures of 50°C and 90°C. The synthesis of colloidal silver nanoparticles (AgNPs) was monitored by the use of UV-visible spectroscopy at different temperatures and time intervals...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28406927/application-of-a-household-based-molecular-xenomonitoring-strategy-to-evaluate-the-lymphatic-filariasis-elimination-program-in-tamil-nadu-india
#7
Swaminathan Subramanian, Purushothaman Jambulingam, Brian K Chu, Candasamy Sadanandane, Venkatesan Vasuki, Adinarayanan Srividya, Mohamed S Mohideen AbdulKader, Kaliannagounder Krishnamoorthy, Harikishan K Raju, Sandra J Laney, Steven A Williams, Ralph H Henderson
BACKGROUND: The monitoring and evaluation of lymphatic filariasis (LF) has largely relied on the detection of antigenemia and antibodies in human populations. Molecular xenomonitoring (MX), the detection of parasite DNA/RNA in mosquitoes, may be an effective complementary method, particularly for detecting signals in low-level prevalence areas where Culex is the primary mosquito vector. This paper investigated the application of a household-based sampling method for MX in Tamil Nadu, India...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28388682/a-low-technology-emanator-treated-with-the-volatile-pyrethroid-transfluthrin-confers-long-term-protection-against-outdoor-biting-vectors-of-lymphatic-filariasis-arboviruses-and-malaria
#8
Sheila B Ogoma, Arnold S Mmando, Johnson K Swai, Sebastian Horstmann, David Malone, Gerry F Killeen
BACKGROUND: The vapor phase of the volatile pyrethroid transfluthrin incapacitates mosquitoes and prevents them from feeding. Although existing emanator products for delivering volatile pyrethroids protect against outdoor mosquito bites, they are too short-lived to be practical or affordable for routine use in low-income settings. New transfluthrin emanators, comprised simply of treated hessian fabric strips, have recently proven highly protective against outdoor-biting vectors of lymphatic filariasis, arboviruses and malaria, but their full protective lifespan, minimum dose requirements, and range of protection have not previously been assessed...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28381279/loa-loa-vectors-chrysops-spp-perspectives-on-research-distribution-bionomics-and-implications-for-elimination-of-lymphatic-filariasis-and-onchocerciasis
#9
REVIEW
Louise Kelly-Hope, Rossely Paulo, Brent Thomas, Miguel Brito, Thomas R Unnasch, David Molyneux
BACKGROUND: Loiasis is a filarial disease caused Loa loa. The main vectors are Chrysops silacea and C. dimidiata which are confined to the tropical rainforests of Central and West Africa. Loiasis is a mild disease, but individuals with high microfilaria loads may suffer from severe adverse events if treated with ivermectin during mass drug administration campaigns for the elimination of lymphatic filariasis and onchocerciasis. This poses significant challenges for elimination programmes and alternative interventions are required in L...
April 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28372977/effect-of-3-years-of-biannual-mass-drug-administration-with-albendazole-on-lymphatic-filariasis-and-soil-transmitted-helminth-infections-a-community-based-study-in-republic-of-the-congo
#10
Sébastien D S Pion, Cédric B Chesnais, Gary J Weil, Peter U Fischer, François Missamou, Michel Boussinesq
BACKGROUND: The standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central Africa, because of the risk of serious adverse events in people with high Loa loa microfilaraemia. Thus, alternative strategies are needed. We investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in Republic of the Congo. METHODS: In 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in Republic of the Congo...
March 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28372976/elimination-of-lymphatic-filariasis-in-loa-loa-areas
#11
Antonio Montresor, Jonathan D King
No abstract text is available yet for this article.
March 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28369129/reaching-endpoints-for-lymphatic-filariasis-elimination-results-from-mass-drug-administration-and-nocturnal-blood-surveys-south-gujarat-india
#12
Anjali Modi, Sukesha Gamit, Bharat S Jesalpura, George Kurien, Jayendra K Kosambiya
BACKGROUND: Following the World Health Assembly resolution on Elimination of lymphatic filariasis (ELF) as a public health problem by the year 2020, a Global Program (GPELF) was launched in 1997 to help endemic countries to initiate national programs. The current strategy to interrupt transmission of LF, is administration of once-yearly, single-dose, two-drug regimen (Albendazole with Diethylcarbamazine (DEC) to be used in endemic areas with the goal of reaching 65% epidemiological coverage for 4-6 years...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28367033/microfilaria-in-pleural-fluid-cytology-a-rare-finding
#13
Subrata Pal, Kingshuk Bose, Abhishek Sharma, Mrinal Sikder
Lymphatic filariasis is endemic in India and Southeast Asia. Detection of microfilaria is infrequently reported during cytological evaluation of various lesions or body cavity fluids. Presence of microfilaria in pleural fluid cytology is very rare finding even in endemic areas. Few cases of accidental finding of microfilaria have been reported in association with malignant pleural effusion. But pleural effusion of filarial origin is extremely rare manifestation. Here we report a classical case of microfilaria in pleural fluid cytology...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28366168/measuring-the-physical-and-economic-impact-of-filarial-lymphoedema-in-chikwawa-district-malawi-a-case-control-study
#14
Michelle C Stanton, Masato Yamauchi, Square Z Mkwanda, Paul Ndhlovu, Dorothy Emmie Matipula, Charles Mackenzie, Louise A Kelly-Hope
BACKGROUND: Lymphatic filariasis (LF) is one of the primary causes of lymphoedema in sub-Saharan Africa, and has a significant impact on the quality of life (QoL) of those affected. In this paper we assess the relative impact of lymphoedema on mobility and income in Chikwawa district, Malawi. METHODS: A random sample of 31 people with lymphoedema and 31 matched controls completed a QoL questionnaire from which both an overall and a mobility-specific score were calculated...
April 3, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28358880/defining-brugia-malayi-and-wolbachia-symbiosis-by-stage-specific-dual-rna-seq
#15
Alexandra Grote, Denis Voronin, Tao Ding, Alan Twaddle, Thomas R Unnasch, Sara Lustigman, Elodie Ghedin
BACKGROUND: Filarial nematodes currently infect up to 54 million people worldwide, with millions more at risk for infection, representing the leading cause of disability in the developing world. Brugia malayi is one of the causative agents of lymphatic filariasis and remains the only human filarial parasite that can be maintained in small laboratory animals. Many filarial nematode species, including B. malayi, carry an obligate endosymbiont, the alpha-proteobacteria Wolbachia, which can be eliminated through antibiotic treatment...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28351683/oleanolic-acid-from-antifilarial-triterpene-saponins-of-dipterocarpus-zeylanicus-induces-oxidative-stress-and-apoptosis-in-filarial-parasite-setaria-digitata-in%C3%A2-vitro
#16
K S Senathilake, E H Karunanayake, S R Samarakoon, K H Tennekoon, E D de Silva, A Adhikari
Absence of a drug that kills adult filarial parasites remains the major challenge in eliminating human lymphatic filariasis (LF); the second leading cause of long-term and permanent disability. Thus, the discovery of novel antifilarial natural products with potent adulticidal activity is an urgent need. In the present study, methanol extracts of leaves, bark and winged seeds of Dipterocarpus zeylanicus (Dipterocarpaceae) were investigated for macro and microfilaricidal activity. Two antifilarial triterpene saponins were isolated from winged seed extracts by bioactivity guided chromatographic separation and identified using Nuclear Magnetic Resonance and mass spectroscopic analysis as oleanolic acid 3-O-β-D- glucopyranoside (1) (IC50 = 20...
March 27, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28342733/probing-intermolecular-interactions-in-a-diethylcarbamazine-citrate-salt-by-fast-mas-1-h-solid-state-nmr-spectroscopy-and-gipaw-calculations
#17
Tiago Venâncio, Lyege Magalhaes Oliveira, Javier Ellena, Nubia Boechat, Steven P Brown
Fast magic-angle spinning (MAS) NMR is used to probe intermolecular interactions in a diethylcarbamazine salt, that is widely used as a treatment against adult worms of Wuchereria bancrofti which cause a common disease in tropical countries named filariasis. Specifically, a dihydrogen citrate salt that has improved thermal stability and solubility as compared to the free form is studied. One-dimensional (1)H, (13)C and (15)N and two-dimensional (1)H-(13)C and (14)N-(1)H heteronuclear correlation NMR experiments under moderate and fast MAS together with GIPAW (CASTEP) calculations enable the assignment of the (1)H, (13)C and (14)N/(15)N resonances...
March 2, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28333930/fifteen-years-of-programme-implementation-for-the-elimination-of-lymphatic-filariasis-in-ghana-impact-of-mda-on-immunoparasitological-indicators
#18
Nana-Kwadwo Biritwum, Dziedzom K de Souza, Benjamin Marfo, Samuel Odoom, Bright Alomatu, Odame Asiedu, Abednego Yeboah, Tei E Hervie, Ernest O Mensah, Paul Yikpotey, Joseph B Koroma, David Molyneux, Moses J Bockarie, John O Gyapong
No abstract text is available yet for this article.
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28331047/ascension-island-a-survey-to-assess-the-presence-of-zika-virus-vectors
#19
G Bullivant, A F Martinou
BACKGROUND AND AIM: Following concerns regarding the spread of Zika virus, Joint Services Health Unit (Cyprus) were tasked to carry out a mosquito survey on the Ascension Island, South Atlantic. This was to determine if vectors of the virus such as Aedes aegypti and Aedes albopictus were introduced and established on the Island. METHODS: An extensive survey of residential areas and natural habitats was initiated in order to collect mosquito larvae and adults by methods such as larval sampling, adult trapping and human landing catches...
March 22, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28329346/posttreatment-reactions-after-single-dose-diethylcarbamazine-or-ivermectin-in-subjects-with-loa-loa-infection
#20
RANDOMIZED CONTROLLED TRIAL
Jesica A Herrick, Fanny Legrand, Raceline Gounoue, Godwin Nchinda, Céline Montavon, Jean Bopda, Steve Mbickmen Tchana, Bienvenu Etogo Ondigui, Konrad Nguluwe, Michael P Fay, Michelle Makiya, Simon Metenou, Thomas B Nutman, Joseph Kamgno, Amy D Klion
Background.: Severe adverse reactions have been observed in individuals with Loa loa infection treated with either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in Africa. In this study, posttreatment clinical and immunologic reactions were compared following single-dose therapy with DEC or IVM to assess whether these reactions have the same underlying pathophysiology...
April 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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