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https://www.readbyqxmd.com/read/28804661/imported-asymptomatic-bancroftian-filariasis-discovered-from-a-plasmodium-vivax-infected-patient-a-case-report-from-singapore
#1
Jean-Marc Chavatte, Roland Jureen
Human lymphatic filariasis is a vector-borne disease mainly caused by the parasitic nematode Wuchereria bancrofti and transmitted worldwide within the tropical and subtropical regions. Singapore was once endemic for bancroftian filariasis but recent reports are scarce and the disease is nearly forgotten. The case report presented here reports the incidental hospital laboratory finding of an asymptomatic microfilaremia in a relapsing Plasmodium vivax imported case during a malaria treatment follow-up appointment...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28794687/prevalence-and-risk-factors-associated-with-lymphatic-filariasis-in-american-samoa-after-mass-drug-administration
#2
Shaun P Coutts, Jonathan D King, Molisamoa Pa'au, Saipale Fuimaono, Joseph Roth, Mary Rose King, Patrick J Lammie, Colleen L Lau, Patricia M Graves
BACKGROUND: In 2000, American Samoa had 16.5% prevalence of lymphatic filariasis (LF) antigenemia. Annual mass drug administration (MDA) was conducted using single-dose albendazole plus diethylcarbamazine from 2000 to 2006. This study presents the results of a 2007 population-based PacELF C-survey in all ages and compares the adult filarial antigenemia results of this survey to those of a subsequent 2010 survey in adults with the aim of improving understanding of LF transmission after MDA...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28793168/how-frank-hawking-dm-and-table-salt-helped-eliminate-lymphatic-filariasis-from-china
#3
Justin D Arnold, Saurabh Singh
No abstract text is available yet for this article.
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28789852/recombinant-calponin-of-human-filariid-brugia-malayi-secondary-structure-and-immunoprophylactic-potential
#4
Shiv K Verma, Ashish Arora, P Kalpana Murthy
In the search for potential vaccine candidates for the control of human lymphatic filariasis, we recently identified calponin-like protein, that regulates actin/myosin interactions, in a proinflammatory fraction F8 (45.24-48.64kDa) of Brugia malayi adult worms. In the present study, the gene was cloned, expressed, and the recombinant Calponin of B. malayi (r-ClpBm) was prepared and characterized. r-ClpBm bears homology with OV9M of Onchocerca volvulus, a non-lymphatic filariid that causes loss of vision and cutaneous pathology...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28765489/embryonal-carcinoma-presenting-as-a-calcified-solitary-testicular-mass-on-ultrasound
#5
Daniel Gerber, Henry Collier Wright, Rachael D Sussman, Lambros Stamatakis
A 24-year-old man presented with a 2-week history of a painless right testicular mass; ultrasound demonstrated a dense, solitary calcified mass. The patient elected observation after further workup showed no evidence of metastasis.A repeat ultrasound 3 months later showed interval growth and the patient underwent right radical orchiectomy. Pathology was consistent with pure embryonal carcinoma of the testis. Calcified testicular masses are typically benign but do carry a differential of spermatic granuloma, large-cell calcifying Sertoli cell tumour, trauma, tuberculosis, filariasis, calcified Leydig cell tumour and burned-out testicular tumour...
July 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28764165/ocular-dirofilariasis-a-rare-case-from-mumbai-india
#6
Sachee Agrawal, Rahul Agrawal, Jayanthi Shastri
Dirofilariasis is a worldwide zoonotic filariasis. Human dirofilariasis is a zoonotic infection most commonly caused by Dirofilariarepens. Dirofilariasis, caused by Dirofilaria repens, has been reported to occur widely throughout Asia, Europe, and Africa. It has not been widely recognized in India; however, several cases have been reported in the last few years. Ease and frequency of international travel has probably contributed to the increase in the number of cases. There is probably a focus of human infection with D...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28756911/the-current-status-of-molecular-xenomonitoring-for-lymphatic-filariasis-and-onchocerciasis
#7
REVIEW
Nils Pilotte, Thomas R Unnasch, Steven A Williams
The capacity of vector insect surveillance to provide estimates of pathogen prevalence and transmission potential has long been recognized within the global communities tasked with eliminating lymphatic filariasis (LF), the underlying cause of elephantiasis and hydrocele, and onchocerciasis (river blindness). Initially restricted to the practice of dissection, the potential of vector monitoring has grown due to the advent of molecular methods capable of increasing the sensitivity and throughput of testing. However, despite such advancement, operational research gaps remain...
July 27, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28749939/a-novel-rapid-test-for-detecting-antibody-responses-to-loa-loa-infections
#8
Bijan Pedram, Valérie Pasquetto, Papa M Drame, Yongchang Ji, Maria J Gonzalez-Moa, Richard K Baldwin, Thomas B Nutman, Marco A Biamonte
Ivermectin-based mass drug administration (MDA) programs have achieved remarkable success towards the elimination of onchocerciasis and lymphatic filariasis. However, their full implementation has been hindered in Central Africa by the occurrence of ivermectin-related severe adverse events (SAEs) in a subset of individuals with high circulating levels of Loa loa microfilariae. Extending MDA to areas with coincident L. loa infection is problematic, and inexpensive point-of-care tests for L. loa are acutely needed...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28749759/criteria-to-stop-mass-drug-administration-for-lymphatic-filariasis-have-been-achieved-throughout-plateau-and-nasarawa-states-nigeria
#9
Abel Eigege, Darin S Evans, Gregory S Noland, Emmanuel Davies, John Umaru, Solomon E Adelamo, Bulus Mancha, Jonathan D King, Emmanuel S Miri, Bridget Okoeguale, Emily P Griswold, Frank O Richards
Nigeria has the largest population at risk for lymphatic filariasis (LF) in Africa. This study used a transmission assessment survey (TAS) to determine whether mass drug administration (MDA) for LF could stop in 21 districts, divided into four evaluation units (EUs), of Plateau and Nasarawa States, Nigeria, after 8-12 years of annual albendazole-ivermectin treatment. A total of 7,131 first- and second-year primary school children (approximately 6-7 years old) were tested for LF antigen by immunochromatographic test (ICT) from May to June 2012...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28742098/pathological-manifestations-in-lymphatic-filariasis-correlate-with-lack-of-inhibitory-properties-of-igg4-antibodies-on-ige-activated-granulocytes
#10
Ulrich F Prodjinotho, Charlotte von Horn, Alex Y Debrah, Linda Batsa Debrah, Anna Albers, Laura E Layland, Achim Hoerauf, Tomabu Adjobimey
Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibody was shown in different models to exhibit immunosuppressive properties. How IgG4 affects the etiopathology of lymphatic filariasis (LF) is however not well characterized. Here we investigate the impact of plasma and affinity-purified IgG/IgG4 fractions from endemic normals (EN) and LF infected pathology patients (CP), asymptomatic microfilaraemic (Mf+) and amicrofilaraemic (Mf-) individuals on IgE/IL3 activated granulocytes...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723904/impact-of-mass-drug-administration-for-elimination-of-lymphatic-filariasis-in-nepal
#11
Chet Raj Ojha, Basant Joshi, Khagendra Prakash Kc, Shyam Prakash Dumre, Keshav Kumar Yogi, Bandana Bhatta, Tulasi Adhikari, Kathryn Crowley, Babu Ram Marasini
BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease transmitted by mosquitoes. Nepal has implemented a national effort to eliminate LF by 2020 through mass drug administration (MDA) using diethylcarbamazine (DEC) and albendazole (ALB). We assessed the impact of MDAs on LF in selected districts of Nepal after the recommended six MDA rounds had been completed. METHODOLOGY AND PRINCIPAL FINDINGS: Baseline surveys were conducted in seven districts and mapping data were used as baseline in the other three districts before starting MDA in 2009...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28722622/side-benefits-of-mass-drug-administration-for-lymphatic-filariasis-on-strongyloides-stercoralis-prevalence-on-pemba-island-tanzania
#12
Beatrice Barda, Marco Albonico, Dora Buonfrate, Shaali M Ame, Said Ali, Benjamin Speich, Jennifer Keiser
Strongyloides stercoralis, although endemic in many countries, is not included in helminth control programs. Few data are available on the prevalence and morbidity linked to this infection. We compared data from two studies conducted in 1998 and 2013 on Pemba Island, Tanzania, involving 525 and 509 schoolchildren, respectively. In 1998, the diagnostic method used was Harada Mori, whereas in 2013 diagnosis was made by both Koga agar plate and Baermann methods. The prevalence registered was 41% in 1998 and 7% in 2013...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28715466/the-antenna-transcriptome-changes-in-mosquito-anopheles-sinensis-pre-and-post-blood-meal
#13
Qian Chen, Di Pei, Jianyong Li, Chengyu Jing, Wenjian Wu, Yahui Man
Antenna is the main chemosensory organ in mosquitoes. Characterization of the transcriptional changes after blood meal, especially those related to chemoreception, may help to explain mosquito blood sucking behavior and to identify novel targets for mosquito control. Anopheles sinensis is an Asiatic mosquito species which transmits malaria and lymphatic filariasis. However, studies on chemosensory biology in female An. sinensis are quite lacking. Here we report a transcriptome analysis of An. sinensis female antennae pre- and post- blood meal...
2017: PloS One
https://www.readbyqxmd.com/read/28708825/lymphatic-filariasis-patient-identification-in-a-large-urban-area-of-tanzania-an-application-of-a-community-led-mhealth-system
#14
Upendo Mwingira, Maria Chikawe, Wilfred Lazarus Mandara, Hayley E Mableson, Cecilia Uisso, Irene Mremi, Alpha Malishee, Mwele Malecela, Charles D Mackenzie, Louise A Kelly-Hope, Michelle C Stanton
BACKGROUND: Lymphatic filariasis (LF) is best known for the disabling and disfiguring clinical conditions that infected patients can develop; providing care for these individuals is a major goal of the Global Programme to Eliminate LF. Methods of locating these patients, knowing their true number and thus providing care for them, remains a challenge for national medical systems, particularly when the endemic zone is a large urban area. METHODOLOGY/PRINCIPLE FINDINGS: A health community-led door-to-door survey approach using the SMS reporting tool MeasureSMS-Morbidity was used to rapidly collate and monitor data on LF patients in real-time (location, sex, age, clinical condition) in Dar es Salaam, Tanzania...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28662054/first-evidence-of-lymphatic-filariasis-transmission-interruption-in-cameroon-progress-towards-elimination
#15
Hugues C Nana-Djeunga, Magellan Tchouakui, Guy R Njitchouang, Jules B Tchatchueng-Mbougua, Philippe Nwane, André Domche, Jean Bopda, Stève Mbickmen-Tchana, Julie Akame, Ann Tarini, Emilienne Epée, Benjamin D Biholong, Yaobi Zhang, Jean J Tougoue, Achille Kabore, Flobert Njiokou, Joseph Kamgno
BACKGROUND: Lymphatic filariasis (LF) is among the 10 neglected tropical diseases targeted for control or elimination by 2020. For LF elimination, the World Health Organization (WHO) has proposed a comprehensive strategy including (i) interruption of LF transmission through large-scale annual treatment (or mass drug administration (MDA)) of all eligible individuals in endemic areas, and (ii) alleviation of LF-associated suffering through morbidity management and disability prevention...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28647380/-lymphedema-of-the-lower-limbs-initial-manifestation-of-gastric-linitis-plastica
#16
S Nguyen, D Ouvrier, D Massalou, P Viau, A Chevallier, S Patouraux, T Passeron, J-P Lacour, H Montaudié
BACKGROUND: Primary lymphedemas are constitutional abnormalities of the lymphatic system. Secondary lymphedemas occur after damage to the lymphatic system, mainly after cancer treatments or tumour mass compression. There are many other causes, including filariasis, which is nonetheless very rare in France. PATIENTS AND METHODS: A 52-year-old man presented with a two-month history of increased size of the left leg. He was asymptomatic and in good general condition...
June 21, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28642878/the-complexity-of-zoonotic-filariasis-episystem-and-its-consequences-a-multidisciplinary-view
#17
REVIEW
Fernando Simón, Javier González-Miguel, Alicia Diosdado, Paula Josefina Gómez, Rodrigo Morchón, Vladimir Kartashev
Vector-borne transmitted helminthic zoonosis affects the health and economy of both developing and developed countries. The concept of episystem includes the set of biological, environmental, and epidemiological elements of these diseases in defined geographic and temporal scales. Dirofilariasis caused by different species of the genus Dirofilaria is a disease affecting domestic and wild canines and felines and man, transmitted by different species of culicid mosquitoes. This complexity is increased because Dirofilaria species harbor intracellular symbiont Wolbachia bacteriae, which play a key role in the embryogenesis and development of dirofilariae and in the inflammatory pathology of the disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28630586/surveillance-efforts-after-mass-drug-administration-to-validate-elimination-of-lymphatic-filariasis-as-a-public-health-problem-in-vanuatu
#18
Fasihah Taleo, George Taleo, Patricia M Graves, Peter Wood, Sung Hye Kim, Masayo Ozaki, Hayley Joseph, Brian Chu, Alex Pavluck, Aya Yajima, Wayne Melrose, Kazuyo Ichimori, Corinne Capuano
BACKGROUND: Vanuatu was formerly highly endemic for lymphatic filariasis (LF), caused by Wuchereria bancrofti and transmitted by Anopheles mosquitoes. After a baseline survey showing 4.8% antigen prevalence in 1998, the country conducted nationwide (in one implementation unit) annual mass drug administration (MDA) with albendazole and diethylcarbamazine citrate from 2000 to 2004 and achieved prevalence of 0.2% by 2006 in a representative nationwide cluster survey among all age groups...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28619504/kolaviron-shows-anti-proliferative-effect-and-down-regulation-of-vascular-endothelial-growth-factor-c-and-toll-like-receptor-2-in-wuchereria-bancrofti-infected-blood-lymphocytes
#19
Aliyu Muhammad, Audu Funmilola, Idowu A Aimola, Iliya S Ndams, Mairo H Inuwa, Andrew J Nok
The anti-proliferative effect and down regulation of vascular endothelial growth factor C and toll like receptor-2 by kolaviron on Wuchereria bancrofti infected peripheral blood lymphocytes were investigated. Blood were collected from consenting volunteers in Talata Mafara, Nigeria, between the hours of 10pm to 12am, and microscopically identified for microfilariae. W. bancrofti positive samples were cultured for 72h treated with Doxycycline (2μg/ml) and kolaviron (5μg/ml) in vitro. Mitotic index, expression of vascular endothelial growth factor-C (VEGF-c), toll like receptor-2 (TLR-2) were determined using standard procedures...
June 12, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28615988/identification-and-control-of-an-isolated-but-intense-focus-of-lymphatic-filariasis-on-satawal-island-federated-states-of-micronesia-in-2003
#20
Moses Pretrick, Wayne Melrose, Jean-Paul Chaine, Deon Canyon, Jaime Carron, Patricia M Graves, Richard S Bradbury
BACKGROUND: There is very limited data available on the prevalence of Bancroftian filariasis in the Federated States of Micronesia (FSM). Considerable attempts to eliminate the disease had occurred in the Pacific region by the year 2003, and the prevalence in FSM was thought to be sufficiently low that the region was considered non-endemic. However, a survey conducted in 2003 on an isolated atoll of FSM, Satawal Island, challenged that assumption. METHODS: Participants on Satawal Island were recruited and their blood tested for Wuchereria bancrofti antigen by the filariasis immunochromatographic test (ICT) card and circulating microfilaria by Knott's concentration technique...
2017: Tropical Medicine and Health
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