Hongxin Liang, Yong Zheng, Zekai Huang, Jinchi Dai, Lintong Yao, Daipeng Xie, Duo Chen, Hongrui Qiu, Huili Wang, Hao Li, Jinhang Leng, Ziming Tang, Dongkun Zhang, Haiyu Zhou
PURPOSE: The research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness. Specifically, there is a gap in comprehending the influence of CD47 on the tumor immune microenvironment, particularly in relation to CD8 + T cells. Our study aims to elucidate the prognostic and immunological relevance of CD47 to enhance insights into its prospective utilities in immunotherapeutic interventions. METHODS: Differential gene expression analysis, prognosis assessment, immunological infiltration evaluation, pathway enrichment analysis, and correlation investigation were performed utilizing a combination of R packages, computational algorithms, diverse datasets, and patient cohorts...
May 8, 2024: Discover. Oncology