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carvedilol v.s bisoprolol

R Endo, U Bahrudin, T Notsu, S Tanno, T Onohara, S Yamaguchi, N Ikeda, B Surastri, Y Nakayama, H Ninomiya, Y Shirayoshi, Y Inagaki, K Yamamoto, A Yoshida, I Hisatome
BACKGROUND: Besides its antiarrhythmic action, carvedilol has an activity to suppress cardiac tissue damage. However, it is unknown whether it has any effect on cellular apoptosis and ion channel remodelling. PURPOSE: To know whether carvedilol has any effect on apoptosis and ion channel remodeling of HL-1 cells expressing E334K MyBPC, and comparing it with bisoprolol. METHOD: We examined effects of carvedilol and bisoprolol on the levels of pro- and anti-apoptotic proteins and ion channels as well as apoptosis of HL-1 cells transfected with E334K MyBPC using Western blot and flow cytometry...
March 2016: Drug Research
J Wikstrand, H Wedel, D Castagno, J J V McMurray
AIMS: The four pivotal beta-blocker trials in heart failure (HF) had different inclusion criteria, making comparison difficult without patient stratifying. The aim of this study was to compare, in similar patients, the effects of bisoprolol, metoprolol controlled release/extended release (CR/XL), carvedilol and nebivolol on (i) total mortality, (ii) all-cause mortality or hospitalization due to cardiovascular causes (time to first event), (iii) all-cause mortality or hospitalization because of HF and (iv) tolerability, defined as discontinuation of randomized treatment...
February 2014: Journal of Internal Medicine
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