keyword
https://read.qxmd.com/read/38513434/local-delivery-of-stem-cell-spheroids-with-protein-polyphenol-self-assembling-armor-to-improve-myocardial-infarction-treatment-via-immunoprotection-and-immunoregulation
#1
JOURNAL ARTICLE
Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which showed significantly enhanced therapeutic efficacy by actively manipulating the hostile pathological MI microenvironment and enabling versatile functionality, including protecting the donor cells from host immune clearance, remodeling the ROS microenvironment and stimulating MSC's pro-healing paracrine secretion...
March 8, 2024: Biomaterials
https://read.qxmd.com/read/37954462/stem-cell-based-therapy-and-cell-free-therapy-as-an-alternative-approach-for-cardiac-regeneration
#2
REVIEW
Iwona Deszcz
The World Health Organization reports that cardiovascular diseases (CVDs) represent 32% of all global deaths. The ineffectiveness of conventional therapies in CVDs encourages the development of novel, minimally invasive therapeutic strategies for the healing and regeneration of damaged tissue. The self-renewal capacity, multilineage differentiation, lack of immunogenicity, and immunosuppressive properties of mesenchymal stem cells (MSCs) make them a promising option for CVDs. However, growing evidence suggests that myocardial regeneration occurs through paracrine factors and extracellular vesicle (EV) secretion, rather than through differentiation into cardiomyocytes...
2023: Stem Cells International
https://read.qxmd.com/read/37394586/sox17-mediated-lpar4-expression-plays-a-pivotal-role-in-cardiac-development-and-regeneration-after-myocardial-infarction
#3
JOURNAL ARTICLE
Jin-Woo Lee, Choon-Soo Lee, HyunJu Son, Jaewon Lee, Minjun Kang, Jinho Chai, Hyun-Jai Cho, Hyo-Soo Kim
Lysophosphatidic acid receptor 4 (LPAR4) exhibits transient expression at the cardiac progenitor stage during pluripotent stem cell (PSC)-derived cardiac differentiation. Using RNA sequencing, promoter analyses, and a loss-of-function study in human PSCs, we discovered that SRY-box transcription factor 17 (SOX17) is an essential upstream factor of LPAR4 during cardiac differentiation. We conducted mouse embryo analyses to further verify our human PSC in vitro findings and confirmed the transient and sequential expression of SOX17 and LPAR4 during in vivo cardiac development...
July 3, 2023: Experimental & Molecular Medicine
https://read.qxmd.com/read/37025170/cellular-heterogeneity-and-stem-cells-of-vascular-endothelial-cells-in-blood-vessel-formation-and-homeostasis-insights-from-single-cell-rna-sequencing
#4
REVIEW
Taku Wakabayashi, Hisamichi Naito
Vascular endothelial cells (ECs) that constitute the inner surface of blood vessels are essential for new vessel formation and organ homeostasis. ECs display remarkable phenotypic heterogeneity across different organs and the vascular tree during angiogenesis and homeostasis. Recent advances in single cell RNA sequencing (scRNA-seq) technologies have allowed a new understanding of EC heterogeneity in both mice and humans. In particular, scRNA-seq has identified new molecular signatures for arterial, venous and capillary ECs in different organs, as well as previously unrecognized specialized EC subtypes, such as the aerocytes localized in the alveolar capillaries of the lung...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/36965699/cellular-reprogramming-of-fibroblasts-in-heart-regeneration
#5
REVIEW
Congwu Chi, Kunhua Song
Myocardial infarction causes the loss of cardiomyocytes and the formation of cardiac fibrosis due to the activation of cardiac fibroblasts, leading to cardiac dysfunction and heart failure. Unfortunately, current therapeutic interventions can only slow the disease progression. Furthermore, they cannot fully restore cardiac function, likely because the adult human heart lacks sufficient capacity to regenerate cardiomyocytes. Therefore, intensive efforts have focused on developing therapeutics to regenerate the damaged heart...
March 23, 2023: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/36567768/human-pluripotent-stem-cell-derived-cardiomyocytes-align-under-cyclic-strain-when-guided-by-cardiac-fibroblasts
#6
JOURNAL ARTICLE
Dylan Mostert, Bart Groenen, Leda Klouda, Robert Passier, Marie-Jose Goumans, Nicholas A Kurniawan, Carlijn V C Bouten
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiomyocytes (CMs) and cardiac fibroblasts (cFBs)] and the extracellular matrix (ECM). Upon ischemic injury, the anisotropic tissue is replaced by disorganized scar tissue, resulting in loss of coordinated contraction. Efforts to re-establish tissue anisotropy in the injured myocardium are hampered by a lack of understanding of how CM and/or cFB structural organization is affected by the two major physical cues inherent in the myocardium: ECM organization and cyclic mechanical strain...
December 2022: APL Bioengineering
https://read.qxmd.com/read/36339573/endogenous-reparative-pluripotent-muse-cells-with-a-unique-immune-privilege-system-hint-at-a-new-strategy-for-controlling-acute-and-chronic-inflammation
#7
REVIEW
Yasumasa Kuroda, Yo Oguma, Kerrigan Hall, Mari Dezawa
Multilineage-differentiating stress enduring (Muse) cells, non-tumorigenic endogenous pluripotent stem cells, reside in the bone marrow (BM), peripheral blood, and connective tissue as pluripotent surface marker SSEA-3(+) cells. They express other pluripotent markers, including Nanog, Oct3/4, and Sox2 at moderate levels, differentiate into triploblastic lineages, self-renew at a single cell level, and exhibit anti-inflammatory effects. Cultured mesenchymal stromal cells (MSCs) and fibroblasts contain several percent of SSEA-3(+)-Muse cells...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36299872/human-embryonic-stem-cell-derived-endothelial-cell-product-injection-attenuates-cardiac-remodeling-in-myocardial-infarction
#8
JOURNAL ARTICLE
Ana-Mishel Spiroski, Ian R McCracken, Adrian Thomson, Marlene Magalhaes-Pinto, Mukesh K Lalwani, Kathryn J Newton, Eileen Miller, Cecile Bénézech, Patrick Hadoke, Mairi Brittan, Joanne C Mountford, Abdelaziz Beqqali, Gillian A Gray, Andrew H Baker
Background: Mechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct evidence of preservation of functional myocardium. Aim: The aim of the study was to investigate tissue remodeling in the infarcted heart following human embryonic stem cell-derived endothelial cell product (hESC-ECP) therapy. Materials and methods: Following coronary artery ligation (CAL) to induce cardiac ischemia, we investigated infarct size at 1 day post-injection in media-injected controls (CALM, n = 11), hESC-ECP-injected mice (CALC, n = 10), and dead hESC-ECP-injected mice (CALD, n = 6); echocardiography-based functional outcomes 14 days post-injection in experimental (CALM, n = 13; CALC, n = 17) and SHAM surgical mice ( n = 4); and mature infarct size (CALM and CALC, both n = 6)...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36217495/exosomes-and-exosomal-cargos-a-promising-world-for-ventricular-remodeling-following-myocardial-infarction
#9
REVIEW
Jiacheng Fang, Yuxuan Zhang, Delong Chen, Yiyue Zheng, Jun Jiang
Exosomes are a pluripotent group of extracellular nanovesicles secreted by all cells that mediate intercellular communications. The effective information within exosomes is primarily reflected in exosomal cargos, including proteins, lipids, DNAs, and non-coding RNAs (ncRNAs), the most intensively studied molecules. Cardiac resident cells (cardiomyocytes, fibroblasts, and endothelial cells) and foreign cells (infiltrated immune cells, cardiac progenitor cells, cardiosphere-derived cells, and mesenchymal stem cells) are involved in the progress of ventricular remodeling (VR) following myocardial infarction (MI) via transferring exosomes into target cells...
2022: International Journal of Nanomedicine
https://read.qxmd.com/read/36056383/oct4-cooperates-with-c-myc-to-improve-mesenchymal-to-endothelial-transition-and-myocardial-repair-of-cardiac-resident-mesenchymal-stem-cells
#10
JOURNAL ARTICLE
Lan Zhao, Jianshuo Wang, Pengzhen Wang, Zhanyu Deng, Jin Cui, Weiguang Huang, Shaoheng Zhang
BACKGROUND: Cardiac-resident mesenchymal stem cells (cMSCs) can exhibit fibrotic, proinflammatory, and proangiogenic phenotype in response to myocardial ischemia (Isch). How their phenotypic fate decisions are determined remains poorly understood. Here, we demonstrate that the cooperation of Oct4 and c-Myc in cMSCs creates a preferable mesenchymal-to-endothelial transition (MEndoT) to promote angiogenesis and consequent myocardial repair. METHODS: We collected MSCs from cardiac and peripheral blood of rat with left ventricular Isch (LV Isch) 30 days after myocardial infarction (MI) or sham operation...
September 2, 2022: Stem Cell Research & Therapy
https://read.qxmd.com/read/35563050/structural-and-functional-support-by-left-atrial-appendage-transplant-to-the-left-ventricle-after-a-myocardial-infarction
#11
JOURNAL ARTICLE
Jussi V Leinonen, Päivi Leinikka, Miikka Tarkia, Milla Lampinen, Avishag K Emanuelov, Ronen Beeri, Esko Kankuri, Eero Mervaala
The left atrial appendage (LAA) of the adult heart has been shown to contain cardiac and myeloid progenitor cells. The resident myeloid progenitor population expresses an array of pro-regenerative paracrine factors. Cardiac constructs have been shown to inhibit deleterious remodeling of the heart using physical support. Due to these aspects, LAA holds promise as a regenerative transplant. LAAs from adult mT/mG mice were transplanted to the recipient 129X1-SvJ mice simultaneously as myocardial infarction (MI) was performed...
April 22, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35038037/oskm-mediated-reversible-reprogramming-of-cardiomyocytes-regenerates-injured-myocardium
#12
JOURNAL ARTICLE
Gregory Farber, Jiandong Liu, Li Qian
Cellular reprogramming has rapidly become a promising methodology to generate new cardiomyocytes from non-cardiomyocyte cell types. Using the transient expression of OSKM factors, Chen et al. demonstrate a unique reprogramming strategy involving the modulation of the resident adult cardiomyocyte identity to an immature proliferative state (Science 373:1537-40, 2021). This OSKM-mediated reversion results in the adoption by adult murine cardiomyocytes of a transcriptional profile similar to cardiomyocytes found in developing hearts, as well as increased proliferative capacity of these reprogrammed cardiomyocytes compared to mature cardiomyocytes...
January 17, 2022: Cell Regeneration
https://read.qxmd.com/read/34955067/feline-hypertrophic-cardiomyopathy-reduced-microvascular-density-and-involvement-of-cd34-interstitial-cells
#13
JOURNAL ARTICLE
Josep M Monné Rodríguez, Sonja Fonfara, Udo Hetzel, Anja Kipar
The sequence of pathological events in feline hypertrophic cardiomyopathy (fHCM) is still largely unknown, although we know that fHCM is characterized by interstitial remodeling in a macrophage-driven pro-inflammatory environment and that myocardial ischemia might contribute to its progression. This study aimed to gain further insights into the structural changes associated with interstitial remodeling in fHCM with special focus on the myocardial microvasculature and the phenotype of the interstitial cells...
December 27, 2021: Veterinary Pathology
https://read.qxmd.com/read/34812500/cardiomyocyte-gsk-3%C3%AE-deficiency-induces-cardiac-progenitor-cell-proliferation-in-the-ischemic-heart-through-paracrine-mechanisms
#14
JOURNAL ARTICLE
Ayesha M Yusuf, Rizwan Qaisar, Abaher O Al-Tamimi, Manju Nidagodu Jayakumar, James R Woodgett, Walter J Koch, Firdos Ahmad
Cardiomyopathy is an irreparable loss and novel strategies are needed to induce resident cardiac progenitor cell (CPC) proliferation in situ to enhance the possibility of cardiac regeneration. Here, we sought to identify the potential roles of glycogen synthase kinase-3β (GSK-3β), a critical regulator of cell proliferation and differentiation, in CPC proliferation post-myocardial infarction (MI). Cardiomyocyte-specific conditional GSK-3β knockout (cKO) and littermate control mice were employed and challenged with MI...
November 23, 2021: Journal of Cellular Physiology
https://read.qxmd.com/read/34794691/basic-and-translational-research-in-cardiac-repair-and-regeneration-jacc%C3%A2-state-of-the-art%C3%A2-review
#15
REVIEW
Jianyi Zhang, Roberto Bolli, Daniel J Garry, Eduardo Marbán, Philippe Menasché, Wolfram-Hubertus Zimmermann, Timothy J Kamp, Joseph C Wu, Victor J Dzau
This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors' own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes...
November 23, 2021: Journal of the American College of Cardiology
https://read.qxmd.com/read/34623174/novel-mechanisms-of-exosome-mediated-phagocytosis-of-dead-cells-in-injured-heart
#16
JOURNAL ARTICLE
Mallikarjun Patil, Sherin Saheera, Praveen K Dubey, Asher Kahn-Krell, Prem Kumar Govindappa, Sarojini Singh, Sultan Tousif, Qinkun Zhang, Hind Lal, Jianyi Zhang, Gangjian Qin, Prasanna Krishnamurthy
[Figure: see text].
November 12, 2021: Circulation Research
https://read.qxmd.com/read/34502175/combinational-therapy-of-cardiac-atrial-appendage-stem-cells-and-pyridoxamine-the-road-to-cardiac-repair
#17
JOURNAL ARTICLE
Lize Evens, Hanne Beliën, Sarah D'Haese, Sibren Haesen, Maxim Verboven, Jean-Luc Rummens, Annelies Bronckaers, Marc Hendrikx, Dorien Deluyker, Virginie Bito
Myocardial infarction (MI) occurs when the coronary blood supply is interrupted. As a consequence, cardiomyocytes are irreversibly damaged and lost. Unfortunately, current therapies for MI are unable to prevent progression towards heart failure. As the renewal rate of cardiomyocytes is minimal, the optimal treatment should achieve effective cardiac regeneration, possibly with stem cells transplantation. In that context, our research group identified the cardiac atrial appendage stem cells (CASCs) as a new cellular therapy...
August 27, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34502068/non-coding-rnas-in-stem-cell-regulation-and-cardiac-regeneration-current-problems-and-future-perspectives
#18
REVIEW
Victor Schweiger, Ena Hasimbegovic, Nina Kastner, Andreas Spannbauer, Denise Traxler, Mariann Gyöngyösi, Julia Mester-Tonczar
Although advances in rapid revascularization strategies following acute myocardial infarction (AMI) have led to improved short and long-term outcomes, the associated loss of cardiomyocytes and the subsequent remodeling result in an impaired ventricular function that can lead to heart failure or death. The poor regenerative capacity of the myocardium and the current lack of effective regenerative therapies have driven stem cell research in search of a possible solution. One approach involves the delivery of stem cells to the site of injury in order to stimulate repair response...
August 25, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34480804/bidirectional-relationship-between-cardiac-extracellular-matrix-and-cardiac-cells-in-ischemic-heart-disease
#19
JOURNAL ARTICLE
Hyun-Ji Park, Kenneth J De Jesus Morales, Sruti Bheri, Brandon P Kassouf, Michael E Davis
Ischemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsulate the cells in a matrix or three-dimensional construct, so as to provide structural support and better mimic the cells' physiological microenvironment during administration...
September 4, 2021: Stem Cells
https://read.qxmd.com/read/34440467/intracellular-development-of-resident-cardiac-stem-cells-an-overlooked-phenomenon-in-myocardial-self-renewal-and-regeneration
#20
JOURNAL ARTICLE
Galina Belostotskaya, Dmitry Sonin, Michael Galagudza
At present, the approaches aimed at increasing myocardial regeneration after infarction are not available. The key question is the identity of cells capable of producing functional cardiac myocytes (CMs), replenishing those lost during ischemia. With identification of resident cardiac stem cells (CSCs), it has been supposed that this cell population may be crucial for myocardial self-renewal and regeneration. In the last few years, the focus has been shifted towards another concept, implying that new CMs are produced by dedifferentiation and proliferation of mature CMs...
July 21, 2021: Life
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