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Resident myocardial stem cells

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https://www.readbyqxmd.com/read/27591224/tnf-receptor-signaling-inhibits-cardiomyogenic-differentiation-of-cardiac-stem-cells-and-promotes-a-neuroadrenergic-like-fate
#1
Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Qianhong Li, Steven P Jones, Aruni Bhatnagar, Roberto Bolli, Sumanth D Prabhu
Despite expansion of resident cardiac stem cells (CSCs; c-kit(+)Lin(-)) after myocardial infarction, endogenous repair processes are insufficient to prevent adverse cardiac remodeling and heart failure (HF). This suggests that the microenvironment in post-ischemic and failing hearts compromises CSC regenerative potential. Inflammatory cytokines, such as tumor necrosis factor-α (TNF), are increased after infarction and in HF; whether they modulate CSC function is unknown. As the effects of TNF are specific to its two receptors (TNFRs), we tested the hypothesis that TNF differentially modulates CSC function in a TNFR-specific manner...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27516007/bringing-cardiac-stem-cell-therapy-from-bench-to-bedside-lessons-from-the-past-and-future-perspectives
#2
Miruna Mihaela Micheu, Alexandru Scafa-Udrişte, Maria DorobanŢu
Findings in the cardiology field from the last three decades of the 20th century were ruled by the theory that the heart is a post-mitotic organ, incapable to regenerate. Recent studies have brought evidences regarding the existence of some cells residing in the adult heart, having stem properties. These cardiac stem cells (CSCs) govern myocardial homeostasis and repair by differentiating into new cardiomyocytes, smooth muscle cells and vascular endothelial cells and also by releasing proangiogenic and procardiogenic cytokines...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27453275/mesenchymal-stem-cell-derived-exosomes-a-novel-potential-therapeutic-avenue-for-cardiac-regeneration
#3
S Safari, F Malekvandfard, S Babashah, A Alizadehasl, M Sadeghizadeh, M Motavaf
Coronary artery diseases (CADs) represent a significant cause of death worldwide. During recent decades the rate of cardiovascular mortality has been declined as a result of modern medicine and surgery. However, despite the fact that cardiac cells, including cardiomyocytes (CMCs), vascular smooth muscle cells (VSMC) and vascular endothelial cells (VEC), can be regenerated by cardiac adult stem cell, the regenerative capacity of these cells are limited and inadequate to functionally regenerate heart damaged tissue...
2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27345618/bone-marrow-is-a-reservoir-for-cardiac-resident-stem-cells
#4
Na Liu, Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, Zongjin Li
Resident cardiac stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and have a significant function in myocardial homeostasis and injury. However, the distribution, origin, homing and possible therapeutic benefits of CSCs are still under discussion. Here we investigated whether bone marrow (BM) stem cells could contribute to repopulating the pool of CSCs in heart. The engraftment of BM cells in heart was detected at a low level after BM transplantation (BMT) and ischemia/reperfusion (I/R) could increase BM cells engraftment but not significant...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27341741/challenges-to-success-in-heart-failure-cardiac-cell-therapies-in-patients-with-heart-diseases
#5
Hidemasa Oh, Hiroshi Ito, Shunji Sano
Heart failure remains the leading cause of death worldwide, and is a burgeoning problem in public health due to the limited capacity of postnatal hearts to self-renew. The pathophysiological changes in injured hearts can sometimes be manifested as scar formation or myocardial degradation, rather than supplemental muscle regeneration to replenish lost tissue during the healing processes. Stem cell therapies have been investigated as a possible treatment approach for children and adults with potentially fatal cardiovascular disease that does not respond to current medical therapies...
June 21, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27298624/differentiation-associated-microrna-alterations-in-mouse-heart-derived-sca-1-cd31-and-sca-1-cd31-cells
#6
Qiong Wu, Jinxi Zhan, Yun Li, Xiaoxia Wang, Lu Xu, Juan Yu, Shiming Pu, Zuping Zhou
Cardiac resident stem/progenitor cells (CSC/CPCs) are critical to the cellular and functional integrity of the heart because they maintain myocardial cell homeostasis. Several populations of CSC/CPCs have been identified based on expression of different stem cell-associated antigens. Sca-1(+) cells in the cardiac tissue may be the most common CSC/CPCs. However, they are a heterogeneous cell population and, in transplants, clinicians might transplant more endothelial cells, cardiomyocytes, or other cells than stem cells...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27222265/from-bone-marrow-to-cardiac-atrial-appendage-stem-cells-for-cardiac-repair-a-review
#7
REVIEW
Marc Hendrikx, Yanick Fanton, Leen Willems, Annick Daniels, Jeroen Declercq, Severina Windmolders, Karen Hensen, Remco Koninckx, Luc Jamaer, Jasperina Dubois, Dagmara Dilling-Boer, Jos Vandekerkhof, Filip Hendrikx, Eric Bijnens, Nick Heuts, Boris Robic, Virginie Bito, Marcel Ameloot, Paul Steels, Jean-Luc Rummens
Traditionally the heart is considered a terminally differentiated organ. However, at the beginning of this century increased mitotic activity was reported in ischemic and idiopathic dilated cardiomyopathy hearts, compared to healthy controls, underscoring the potential of regeneration after injury. Due to the presence of adult stem cells in bone marrow and their purported ability to differentiate into other cell lineages, this cell population was soon estimated to be the most suited candidate for cardiac regeneration...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27109964/first-evidence-of-cardiac-stem-cells-from-the-left-ventricular-apical-tip-in-patients-with-left-ventricular-assist-device-implantation
#8
M Cameli, F M Righini, S Sparla, D Tacchini, A Dokollari, C G Sassi, C Di Tommaso, V Curci, S Censini, E Incampo, F Cassano, G Droandi, S Bernazzali, M Focardi, F Ietta, L Sartiani, R Romagnoli, G Marotta, A Mugelli, L Paulesu, G Sani, P Tanganelli, M Maccherini, S Mondillo
BACKGROUND: Recent studies have challenged the dogma that the adult heart is a postmitotic organ and raise the possibility of the existence of resident cardiac stem cells (CSCs). Our study aimed to explore if these CSCs are present in the "ventricular tip" obtained during left ventricular assist device (LVAD) implantation from patients with end-stage heart failure (HF) and the relationship with LV dysfunctional area extent. METHODS: Four consecutive patients with ischemic cardiomyopathy and end-stage HF submitted to LVAD implantation were studied...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27056755/edaravone-promotes-activation-of-resident-cardiac-stem-cells-by-transplanted-mesenchymal-stem-cells-in-a-rat-myocardial-infarction-model
#9
Guang-Wei Zhang, Tian-Xiang Gu, Xue-Jun Sun, Chunyue Wang, Xun Qi, Xiao-Bing Wang, Jesse Li-Ling
OBJECTIVE: To explore the effect of edaravone on bone marrow mesenchymal stem cells (BMSCs) transplanted to treat acute myocardial infarction (AMI) and the underlying mechanism. METHODS: After pretreatment or treatment with edaravone under conditions of deep hypoxia and serum deprivation, the rat BMSCs were evaluated for reactive oxygen species (ROS), Akt pathway, apoptosis, migration, and paracrine function mediating cardiac stem cell (CSC) activation. Edaravone-pretreated BMSCs, control-released edaravone, and BMSCs were respectively transplanted into a rat AMI model...
August 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26903387/harnessing-the-secretome-of-cardiac-stem-cells-as-therapy-for-ischemic-heart-disease
#10
REVIEW
Ramin Khanabdali, Ayeshah A Rosdah, Gregory J Dusting, Shiang Y Lim
Adult stem cells continue to promise opportunities to repair damaged cardiac tissue. However, precisely how adult stem cells accomplish cardiac repair, especially after ischemic damage, remains controversial. It has been postulated that the clinical benefit of adult stem cells for cardiovascular disease results from the release of cytokines and growth factors by the transplanted cells. Studies in animal models of myocardial infarction have reported that such paracrine factors released from transplanted adult stem cells contribute to improved cardiac function by several processes...
August 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/26820972/generation-and-characterization-of-human-cardiac-resident-and-non-resident-mesenchymal-stem-cell
#11
Baskar Subramani, Sellamuthu Subbannagounder, Sekar Palanivel, Chithra Ramanathanpullai, Sivakumar Sivalingam, Azhari Yakub, Manjunath SadanandaRao, Arivudainambi Seenichamy, Ashok Kumar Pandurangan, Jun Jie Tan, Rajesh Ramasamy
Despite the surgical and other insertional interventions, the complete recuperation of myocardial disorders is still elusive due to the insufficiency of functioning myocardiocytes. Thus, the use of stem cells to regenerate the affected region of heart becomes a prime important. In line with this human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have gained considerable interest due to their potential use for mesodermal cell based replacement therapy and tissue engineering. Since MSCs are harvested from various organs and anatomical locations of same organism, thus the cardiac regenerative potential of human cardiac-derived MSCs (hC-MSCs) and human umbilical cord Wharton's Jelly derived MSC (hUC-MSCs) were tested concurrently...
October 2016: Cytotechnology
https://www.readbyqxmd.com/read/26662989/microrna-and-cardiac-regeneration
#12
Massimiliano Gnecchi, Federica Pisano, Riccardo Bariani
Heart diseases are a very common health problem in developed as well as developing countries. In particular, ischemic heart disease and heart failure represent a plague for the patients and for the society. Loss of cardiac tissue after myocardial infarction or dysfunctioning tissue in nonischemic cardiomyopathies may result in cardiac failure. Despite great advancements in the treatment of these diseases, there is a substantial unmet need for novel therapies, ideally addressing repair and regeneration of the damaged or lost myocardium...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26515110/resident-c-kit-cells-in-the-heart-are-not-cardiac-stem-cells
#13
Nishat Sultana, Lu Zhang, Jianyun Yan, Jiqiu Chen, Weibin Cai, Shegufta Razzaque, Dongtak Jeong, Wei Sheng, Lei Bu, Mingjiang Xu, Guo-Ying Huang, Roger J Hajjar, Bin Zhou, Anne Moon, Chen-Leng Cai
Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By targeting the c-kit locus with multiple reporter genes in mice, we find that c-kit expression rarely co-localizes with the expression of the cardiac progenitor and myogenic marker Nkx2...
October 30, 2015: Nature Communications
https://www.readbyqxmd.com/read/26426466/aging-effects-on-cardiac-progenitor-cell-physiology
#14
REVIEW
Marcello Rota, Polina Goichberg, Piero Anversa, Annarosa Leri
Cardiac aging has been confounded by the concept that the heart is a postmitotic organ characterized by a predetermined number of myocytes, which is established at birth and largely preserved throughout life until death of the organ and organism. Based on this premise, the age of cardiac cells should coincide with that of the organism; at any given time, the heart would be composed of a homogeneous population of myocytes of identical age. The discovery that stem cells reside in the heart and generate cardiac cell lineages has imposed a reconsideration of the mechanisms implicated in the manifestations of the aging myopathy...
October 2015: Comprehensive Physiology
https://www.readbyqxmd.com/read/26280107/identification-of-cardiac-stem-cells-within-mature-cardiac-myocytes
#15
Galina Belostotskaya, Alexey Nevorotin, Michael Galagudza
Cardiac stem cells are described in a number of mammalian species including humans. Cardiac stem cell clusters consisting of both lineage-negative and partially committed cells are generally identified between contracting cardiac myocytes. In the present study, c-kit(+), Sca(+), and Isl1(+) stem cells were revealed to be located inside the sarcoplasm of cardiac myocytes in myocardial cell cultures derived from newborn, 20-, and 40-day-old rats. Intracellularly localized cardiac stem cells had a coating or capsule with a few pores that opened into the host cell sarcoplasm...
2015: Cell Cycle
https://www.readbyqxmd.com/read/26187727/transplantation-of-adipose-tissue-mesenchymal-cells-conjugated-with-vegf-releasing-microcarriers-promotes-repair-in-murine-myocardial-infarction
#16
Rosalinda Madonna, Lyubomir Petrov, Maria Anna Teberino, Lamberto Manzoli, Jean-Pierre Karam, Francesca Vera Renna, Peter Ferdinandy, Claudia N Montero-Menei, Seppo Ylä-Herttuala, Raffaele De Caterina
RATIONALE: Engraftment and survival of transplanted stem or stromal cells in the microenvironment of host tissues may be improved by combining such cells with scaffolds to delay apoptosis and enhance regenerative properties. AIMS: We examined whether poly(lactic-co-glycolic acid) pharmacologically active microcarriers (PAMs) releasing vascular endothelial growth factor (VEGF) enhance survival, differentiation, and angiogenesis of adipose tissue-mesenchymal stromal cells (AT-MSCs)...
October 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/26184084/cardiac-repair-with-a-novel-population-of-mesenchymal-stem-cells-resident-in-the-human-heart
#17
Yuan Zhang, Priyadharshini Sivakumaran, Andrew E Newcomb, Damián Hernandez, Nicole Harris, Ramin Khanabdali, Guei-Sheung Liu, Darren J Kelly, Alice Pébay, Alex W Hewitt, Andrew Boyle, Richard Harvey, Wayne A Morrison, David A Elliott, Gregory J Dusting, Shiang Y Lim
Cardiac resident stem cells (CRSCs) hold much promise to treat heart disease but this remains a controversial field. Here, we describe a novel population of CRSCs, which are positive for W8B2 antigen and were obtained from adult human atrial appendages. W8B2(+) CRSCs exhibit a spindle-shaped morphology, are clonogenic and capable of self-renewal. W8B2(+) CRSCs show high expression of mesenchymal but not hematopoietic nor endothelial markers. W8B2(+) CRSCs expressed GATA4, HAND2, and TBX5, but not C-KIT, SCA-1, NKX2...
October 2015: Stem Cells
https://www.readbyqxmd.com/read/26165749/isolation-and-characterization-of-cardiogenic-stem-like-cardiac-precursors-from-heart-samples-of-patients-with-congenital-heart-disease
#18
Zaniar Ghazizadeh, Sadaf Vahdat, Faranak Fattahi, Hananeh Fonoudi, Gholamreza Omrani, Maziar Gholampour, Nasser Aghdami
AIMS: Regenerative therapies based on resident human cardiac progenitor cells (hCPCs) are a promising alternative to medical treatments for patients with myocardial infarction. However, hCPCs are rare in human heart and finding efficient source and proper surface marker for isolation of these cells would make them a good candidate for therapy. MAIN METHODS: We have isolated 5.34∗10(6)±2.04∗10(5)/g viable cells from 35 heart tissue samples of 23 patients with congenital heart disease obtained during their heart surgery along with 6 samples from 3 normal subjects during cardiac biopsy...
September 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/26094634/thymosin-%C3%AE-4-multiple-functions-in-protection-repair-and-regeneration-of-the-mammalian-heart
#19
REVIEW
Sveva Bollini, Paul R Riley, Nicola Smart
INTRODUCTION: Despite recent improvements in interventional medicine, cardiovascular disease still represents the major cause of morbidity worldwide, with myocardial infarction being the most common cardiac injury. This has sustained the development of several regenerative strategies based on the use of stem cells and tissue engineering approaches in order to achieve cardiac repair and regeneration by enhancing coronary neovascularization, modulating acute inflammation and supporting myocardial regeneration to provide new functional muscle...
2015: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/26033604/stimulation-of-proliferation-and-differentiation-of-rat-resident-myocardial-cells-with-apoptotic-bodies-of-cardiomyocytes
#20
A I Tyukavin, G B Belostotskaya, T A Golovanova, M M Galagudza, E A Zakharov, N V Burkova, D Yu Ivkin, A A Karpov
Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart...
May 2015: Bulletin of Experimental Biology and Medicine
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