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Demoralization

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https://www.readbyqxmd.com/read/28840375/frizzled-5-a-high-affinity-receptor-for-secreted-frizzled-related-protein-2-activation-of-nuclear-factor-of-activated-t-cells-c3-signaling-to-promote-angiogenesis
#1
Yuri K Peterson, Patrick Nasarre, Ingrid V Bonilla, Eleanor Hilliard, Jennifer Samples, Thomas A Morinelli, Elizabeth G Hill, Nancy Klauber-DeMore
Secreted frizzled-related protein 2 (SFRP2) is a pro-angiogenic factor expressed in the vasculature of a wide variety of human tumors, and modulates angiogenesis via the calcineurin-dependent nuclear factor of activated T-cells cytoplasmic 3 (NFATc3) pathway in endothelial cells. However, until now, SFRP2 receptor for this pathway was unknown. In the present study, we first used amino acid alignments and molecular modeling to demonstrate that SFRP2 interaction with frizzled-5 (FZD5) is typical of Wnt/FZD family members...
August 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28801849/bevacizumab-in-colorectal-cancer-current-role-in-treatment-and-the-potential-of-biosimilars
#2
REVIEW
Lee S Rosen, Ira A Jacobs, Ronald L Burkes
Colorectal cancer (CRC) is a leading cause of tumor-related morbidity and mortality worldwide, with mortality most often attributable to metastatic disease. Bevacizumab, a humanized monoclonal antibody targeting vascular endothelial growth factor, has a significant role in the treatment of metastatic CRC (mCRC). However, patient access to bevacizumab may be limited in some regions or circumstances, owing to factors related to insurance coverage, reimbursement, patient out-of-pocket costs, or availability. As a result, outcomes for patients with mCRC may be worsened...
August 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28789725/demoralization-in-medical-illness-feasibility-and-acceptability-of-a-pilot-educational-intervention-for-inpatient-oncology-nurses
#3
Benjamin W Brewer, Jennifer M Caspari, Jean Youngwerth, Leigh Nathan, Izaskun Ripoll, Alison Heru
OBJECTIVE: Demoralization is a common problem among medical inpatients with such serious health problems as cancer. An awareness of this syndrome, a knowledge of what defines it, and a plan for how to intervene are limited among nursing teams. Nurses are uniquely poised to efficiently provide brief interventions that address demoralization in their patients. To our knowledge, there are no interventions that train nurses to distinguish and treat demoralization in their patients. The objective of the present study was to determine the acceptability, feasibility, and impact of a novel educational intervention for nurses...
August 9, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28756579/evaluation-of-effects-of-an-operational-multidisciplinary-team-on-antibiotic-use-in-the-medium-to-long-term-at-a-french-university-hospital
#4
Béatrice Demoré, Pauline Humbert, Emmanuelle Boschetti, Sibylle Bevilacqua, Isabelle Clerc-Urmès, Thierry May, Céline Pulcini, Nathalie Thilly
Background Antibiotic-resistant bacteria are a major public health problem throughout the world. In 2006, in accordance with the national guidelines for antibiotic use, the CHRU of Nancy created an operational multidisciplinary antibiotic team at one of its sites. In 2011, a cluster-controlled trial showed that the operational multidisciplinary antibiotic team (the intervention) had a favourable short-term effect on antibiotic use and costs. Objective Our objective was to determine whether these effects continued over the medium to long term (that is, 2-7 years after creation of the operational multidisciplinary antibiotic team, 2009-2014)...
July 29, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28753076/the-burden-of-psychosocial-morbidity-related-to-cancer-patient-and-family-issues
#5
Rosangela Caruso, Mara Giulia Nanni, Michelle B Riba, Silvana Sabato, Luigi Grassi
With cancer incidence increasing over time, attention to the burden of related psychiatric and psychosocial consequences of the disease and treatment is a major topic for both cancer patients and their caregivers. Among cancer patients, psychiatric (e.g. adjustment, anxiety, depressive disorders) and neuropsychiatric disorders (e.g. cognitive disorders secondary to treatment, delirium) have been shown to affect an average of 30-35% patients, with differences according to stage and type of cancer. Also other psychosocial syndromes (e...
July 28, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28752229/hope-modules-brief-psychotherapeutic-interventions-to-counter-demoralization-from-daily-stressors-of-chronic-illness
#6
James L Griffith
No abstract text is available yet for this article.
July 27, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28719923/-breaking-bad-news-to-cancer-patients-content-communication-preferences-and-psychological-distress
#7
Claudia Gebhardt, Claudia Gorba, Karin Oechsle, Sigrun Vehling, Uwe Koch, Anja Mehnert
Objectives Breaking bad news can be a very distressing situation for both patients and physicians. Physician communication behavior should therefore match patients' communication preferences. The aim of this study was to characterize the content of bad news from the patients' perspective. Patients' preferences for communication of bad news as well as the fit to communication behavior displayed by physicians were also investigated. Finally, consequences of a mismatch between patients' preferences and physician communication were investigated in relation to psychological distress in patients...
July 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28716619/attachment-insecurity-in-advanced-cancer-patients-psychometric-properties-of-the-german-version-of-the-brief-experiences-in-close-relationships-scale-ecr-m16-g
#8
Philipp Rebecca, Vehling Sigrun, Scheffold Katharina, Grünke Britta, Härter Martin, Mehnert Anja, Schulz-Kindermann Frank, Lo Christopher
CONTEXT: Attachment insecurity refers to difficulty in trusting and relying on others in times of need. Its underlying factors attachment anxiety and attachment avoidance have been empirically associated with impaired coping in advanced cancer, and therefore should be considered in individually tailored medical and psychosocial treatment. OBJECTIVES: To evaluate the psychometric properties of the German translation of the Brief Experiences in Close Relationships Scale (ECR-M16-G)...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28647552/clinical-utility-of-the-patient-health-questionnaire-9-in-the-assessment-of-major-depression-after-broad-spectrum-traumatic-brain-injury
#9
Jacobus Donders, Adriene Pendery
OBJECTIVE: To determine the predictive validity of the Patient Health Questionnaire-9 (PHQ-9) when screening for symptoms of depression after traumatic brain injury. DESIGN: Retrospective analysis of data collected as part of routine clinical outpatient care over a period of 30 months. SETTING: Regional rehabilitation facility. PARTICIPANTS: Persons (N=137) with mild to severe traumatic brain injury who were referred for neuropsychological evaluation within 1 to 12 months...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28622810/exploratory-examination-of-the-utility-of-demoralization-as-a-diagnostic-specifier-for-adjustment-disorder-and-major-depression
#10
D W Kissane, I Bobevski, P Gaitanis, J Brooker, N Michael, C Lethborg, G Richardson, P Webster, C Hempton
OBJECTIVE: Demoralization, a state of lowered morale and poor coping, has a prevalence of 13-18% among patients with advanced cancer. We surveyed clinicians' perspectives of the utility of "with demoralization" as a diagnostic specifier for adjustment and depressive disorders. METHOD: Using comparative clinical vignettes in a field survey, clinicians from a range of disciplines were asked their perception of the utility of diagnosis and treatment options. Response frequencies were compared using Cochran's Q and McNemar's tests, with sensitivity and specificity rated against expert rankings of diagnosis...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28534181/assessing-decision-making-capacity-for-do-not-resuscitate-requests-in-depressed-patients-how-to-apply-the-communication-and-appreciation-criteria
#11
Benjamin D Brody, Ellen C Meltzer, Diana Feldman, Julie B Penzner, Janna S Gordon-Elliot
The Patient Self Determination Act (PSDA) of 1991 brought much needed attention to the importance of advance care planning and surrogate decision-making. The purpose of this law is to ensure that a patient's preferences for medical care are recognized and promoted, even if the patient loses decision-making capacity (DMC). In general, patients are presumed to have DMC. A patient's DMC may come under question when distortions in thinking and understanding due to illness, delirium, depression or other psychiatric symptoms are identified or suspected...
May 22, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28488207/depressive-spectrum-disorders-in-cancer-diagnostic-issues-and-intervention-a-critical-review
#12
REVIEW
Rosangela Caruso, Maria GiuliaNanni, Michelle B Riba, Silvana Sabato, Luigi Grassi
Depressive spectrum disorders, including major depression, persistent depression, minor and sub-syndromal depression, and other forms of depressive conditions, such as demoralization, are among the most common psychiatric consequences of cancer patients, affecting up to 60% of patients. In spite of the negative effects and the burden for cancer patients and their families, these disorders often remain under-recognized and undertreated. The present review aims at summarizing the relevant data concerning the diagnostic challenges within the depressive spectrum disorders among cancer patients...
June 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28472548/the-association-of-demoralization-with-mental-disorders-and-suicidal-ideation-in-patients-with-cancer
#13
Sigrun Vehling, David W Kissane, Christopher Lo, Heide Glaesmer, Tim J Hartung, Gary Rodin, Anja Mehnert
BACKGROUND: Demoralization refers to a state in which there is a perceived inability to cope, that is associated with a sense of disheartenment and a loss of hope and meaning. This study investigated the co-occurrence versus independence of demoralization with mental disorders and suicidal ideation to evaluate its features as a concept of distress in the context of severe illness. METHODS: In a cross-sectional sample of 430 mixed cancer patients, we assessed demoralization with the Demoralization Scale (DS); the 4-week prevalence of mood, anxiety, and adjustment disorders and suicidal ideation with the standardized Composite International Diagnostic Interview-Oncology (CIDI-O); and depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9)...
September 1, 2017: Cancer
https://www.readbyqxmd.com/read/28425726/comparisons-between-the-minnesota-multiphasic-personality-inventory-adolescent-restructured-form-mmpi-a-rf-and-mmpi-a-in-adolescent-psychiatric-inpatients
#14
John M Stokes, David L Pogge, Robert P Archer
This study explored the association between the Minnesota Multiphasic Personality Inventory (MMPI)-Adolescent-Restructured Form (MMPI-A-RF) and the MMPI-Adolescent (MMPI-A) form in a sample of 3,516 adolescents receiving inpatient psychiatric treatment, including 2,798 adolescents meeting validity inclusion cutoffs for both measures. There was 92.5% agreement rate with respect to global identification of cases as valid or invalid and some empirical support for lowering interpretive cutoffs for validity scales on the MMPI-A-RF...
April 20, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28405941/public-knowledge-and-behaviours-concerning-antibiotic-use-and-resistance-in-france-a-cross-sectional-survey
#15
Béatrice Demoré, Lucie Mangin, Gianpiero Tebano, Céline Pulcini, Nathalie Thilly
PURPOSE: To evaluate knowledge and behaviours concerning antibiotics and bacterial resistance in the French population, and to identify the socio-demographic factors associated with a high level of such knowledge and appropriate behaviours. METHODS: A survey of the general population was conducted in 2015 in northeast France. The 44-item standardized questionnaire used comprised three parts, focusing on the assessment of knowledge, behaviours, and the collection of main socio-demographic characteristics of respondents (gender, age, having children, education level, and profession)...
August 2017: Infection
https://www.readbyqxmd.com/read/28388259/the-utility-of-mmpi-2-rf-scale-scores-in-the-differential-diagnosis-of-schizophrenia-and-major-depressive-disorder
#16
Tayla T C Lee, John R Graham, Paul A Arbisi
This study was designed to determine whether scores on selected Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) scales could be used to differentiate between individuals diagnosed with schizophrenia (SCZ) and major depressive disorder (MDD). The sample was drawn from 2 psychiatric inpatient hospitals and included data from 199 individuals with SCZ and 808 individuals with MDD. A series of multivariate analyses of variance, analyses of variance, and odds ratios were calculated to determine which MMPI-2-RF scales provide the best differentiation between individuals presenting with these 2 disorders...
April 7, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28365303/quasi-experimental-study-designs-series-paper-4-uses-and-value
#17
Till Bärnighausen, Peter Tugwell, John-Arne Røttingen, Ian Shemilt, Peter Rockers, Pascal Geldsetzer, John Lavis, Jeremy Grimshaw, Karen Daniels, Annette Brown, Jacob Bor, Jeffery Tanner, Arash Rashidian, Mauricio Barreto, Sebastian Vollmer, Rifat Atun
Quasi-experimental studies are increasingly used to establish causal relationships in epidemiology and health systems research. Quasi-experimental studies offer important opportunities to increase and improve evidence on causal effects: (i) they can generate causal evidence when randomized controlled trials are impossible; (ii) they typically generate causal evidence with a high degree of external validity; (iii) they avoid the threats to internal validity that arise when participants in non-blinded experiments change their behavior in response to the experimental assignment to either intervention or control arm (such as compensatory rivalry or resentful demoralization); (iv) they are often well-suited to generate causal evidence on long-term health outcomes of an intervention, as well as non-health outcomes such as economic and social consequences; and (v) they can often generate evidence faster and at lower cost than experiments and other intervention studies...
March 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#18
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28299710/high-resolution-microultrasound-%C3%AE-us-investigation-of-the-gastrointestinal-gi-tract
#19
Thineskrishna Anbarasan, Christine E M Démoré, Holly Lay, Mohammed R S Sunoqrot, Romans Poltarjonoks, Sandy Cochran, Benjamin F Cox
High resolution, microultrasound (μUS) scanning of the gastrointestinal (GI) tract has potential as an important transmural imaging modality to aid in diagnosis. Operating at higher frequencies than conventional clinical ultrasound instruments, μUS is capable of providing scanned images of the GI tract with higher resolution. To investigate the use of μUS for this application, a phantom which is cost effective, within ethical guidelines and, most importantly, similar in histology to the human GI tract is necessary...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28279121/high-demoralization-in-a-minority-of-oophorectomized-brca1-2-mutation-carriers-influences-quality-of-life
#20
Marieke Arts-de Jong, Cor A J DeJong, Rosella P Hermens, David W Kissane, Leon M Massuger, Nicoline Hoogerbrugge, Judith B Prins, Joanne A deHullu
INTRODUCTION: Demoralization is a relatively neglected issue in which low morale and poor coping result from a stressor such as familial cancer risk. Female BRCA1/2 mutation carriers are highly susceptible for developing breast and ovarian cancer. The aim of this study was to evaluate demoralization in oophorectomized BRCA1/2 mutation carriers and its relation to quality of life. METHODS: This cross-sectional study examined 288 oophorectomized BRCA1/2 mutation carriers using the following standardized self-report measures: Demoralization Scale, EORTC Quality of Life Questionnaire-C30, State-Trait Anxiety Inventory and the Cancer Worry Scale...
March 10, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
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