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Demoralization

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https://www.readbyqxmd.com/read/29323522/demoralization-and-embitterment
#1
Maria Giulia Nanni, Rosangela Caruso, Silvana Sabato, Luigi Grassi
OBJECTIVE: Individuals may experience a wide range of psychological reactions in response to negative life events. Even if events that threaten life have been always played a central role in research, recent studies have outlined that experiences, considered exceptional but part of the human existence (e.g., divorce, unemployment, or chronic illness) may also lead individuals to experience enduring emotional states of suffering. Demoralization has been substantially described as an important condition occurring in response to stressful events, while a recent interest is growing on embitterment as a common reaction...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29312613/dysregulated-connexin-43-in-her2-positive-drug-resistant-breast-cancer-cells-enhances-proliferation-and-migration
#2
Elizabeth S Yeh, Christina J Williams, Carly Bess Williams, Ingrid V Bonilla, Nancy Klauber-DeMore, Stephanie L Phillips
Connexin 43 (Cx43) is a gap junction protein whose function in the development of breast cancer and in breast cancer progression remains unclear. Evidence suggests that Cx43 (GJA1) mRNA and protein expression is altered in breast tumors. However, reports indicate both increased and decreased Cx43 levels in human breast cancer samples. Studies also suggest that loss of Cx43 regulated gap junction intercellular communication is a common feature of breast malignancies that potentially correlates with histological stage...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283986/stigma-and-suicide
#3
Sabina Kučukalić, Abdulah Kučukalić
Suicide is one of the major mental health problems in the world. It is estimated that one million suicide are committed per year and that after every suicide six people from the surrounding suffer or develop major life changes. After suicide survivors are at higher risk of developing major psychological changes and suicidal ideations as well. They go through the complicated process of grief which is specifically characterized by the felling of guilt, shame, denial and anger. The griefing process, more often than in other causes of death, doesn't integrate but is complicated with prolonged grief...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29251694/existential-distress-and-meaning-focused-interventions-in-cancer-survivorship
#4
Sigrun Vehling, Rebecca Philipp
PURPOSE OF REVIEW: Cancer can challenge fundamental assumptions about security, controllability and life priorities, which may lead to clinically relevant existential distress. We review recent studies on the prevalence of existential distress in cancer survivors, its distinctness from other distress concepts and interventions to address cancer-specific existential challenges. We further describe psychological mechanisms that may underlie change resulting from such interventions. RECENT FINDINGS: One-third to one-half of cancer survivors experienced existential fears and concerns related to reduced control, identity and uncertainty about the future...
December 14, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29247405/impact-of-depression-and-demoralization-on-blood-pressure-control-in-african-americans-with-hypertension-findings-from-the-triumph-trial
#5
Emanuela Offidani, Giada Benasi, Mary E Charlson, Joseph E Ravenell, Carla Boutin-Foster
BACKGROUND: African Americans develop hypertension earlier and have worse cardiovascular outcomes than Caucasians. Accumulating evidence suggests that psychological distress may play a role in the observed racial differences in hypertension. Several studies have investigated the relationship between depression and hypertension while little is still known about the role of demoralization. METHODS: Using data from the Trial Using Motivational Interviewing, Positive Affect, and Self-affirmation in African Americans with Hypertension (TRIUMPH), logistic regression models were used to estimate differences in blood pressure control at 12 months among participants with demoralization, depression, and both conditions...
December 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29237326/a-chamber-of-errors-adaptation-to-assess-pharmaceutical-assistants-knowledge-in-chemotherapy-preparation
#6
C Loboda, J Vigneron, C Mulot, I May, B Demore
French preparation guidelines state that pharmacy staff who manipulate cytotoxic drugs have to follow specific training. In order to assess the pharmaceutical assistants' skills and knowledge, we developed a "Cytotoxic Preparation Centralized Unit (CPCU) of errors," derived from the Canadian concept of "Chamber of horrors." A table listing 20 mistakes to track down was created and each pharmaceutical assistant spent 20 min in the "CPCU of errors" with the pharmacist, who wrote down the spotted mistakes in real time...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29237051/pharmacist-participation-in-antimicrobial-stewardship-in-australian-and-french-hospitals-a-cross-sectional-nationwide-survey
#7
Naomi Weier, Gianpiero Tebano, Nathalie Thilly, Béatrice Demoré, Céline Pulcini, Syed Tabish R Zaidi
Background: Hospital pharmacists are an integral part of antimicrobial stewardship (AMS) programmes globally. Currently, little is known as to how hospital pharmacists see their role and involvement within the AMS framework. Objectives: To assess the current level of involvement of Australian and French hospital pharmacists in AMS programmes and identify barriers limiting their involvement in AMS. Methods: Hospital pharmacists throughout Australia and France were invited to participate in a nationwide online survey throughout March-May 2016...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29202493/health-related-quality-of-life-and-mental-health-in-primary-aldosteronism-a-systematic-review
#8
Marieke S Velema, Aline H de Nooijer, Vivian W G Burgers, Ad R M M Hermus, Henri J L M Timmers, Jacques W M Lenders, Olga Husson, Jaap Deinum
The aim of this review was to determine the impact of primary aldosteronism on health-related quality of life (HRQoL) and mental health. We performed a systematic literature search up to July 2017 in six electronic databases. First, we screened the articles derived from this search based on title and abstract. Second, the selected studies were systematically reviewed and checked for our predefined inclusion criteria. The search yielded 753 articles, of which 15 studies met our inclusion criteria. Untreated patients with primary aldosteronism showed an impaired physical and mental HRQoL as compared to the general population...
December 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29155291/measuring-the-psychosocial-dimensions-of-quality-of-life-in-advanced-cancer-patients-psychometrics-of-the-german-quality-of-life-at-the-end-of-life-cancer-psychosocial-qual-ec-p-questionnaire
#9
Britta Grünke, Rebecca Philipp, Sigrun Vehling, Katharina Scheffold, Martin Härter, Karin Oechsle, Frank Schulz-Kindermann, Anja Mehnert, Christopher Lo
CONTEXT: Quality of life is a central focus of care in advanced cancer. Specialized instruments, such as the QUAL-EC, may be useful to assess psychosocial issues associated with quality of life unique to this population. OBJECTIVES: To evaluate the measurement of the psychosocial dimensions of quality of life using the German translation of the QUAL-EC-Cancer-Psychosocial Questionnaire (QUAL-EC-P), including factor structure and psychometrics. METHODS: 183 patients with advanced cancer from the University Medical Center Hamburg-Eppendorf and University Medical Center Leipzig completed the QUAL-EC-P...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29079383/surgery-type-and-psychosocial-factors-contribute-to-poorer-weight-loss-outcomes-in-persons-with-a-body-mass-index-greater-than-60-kg-m-2
#10
Ryan J Marek, Gail A Williams, Samantha H Mohun, Leslie J Heinberg
BACKGROUND: The current investigation aims to predict 3-year postoperative percent total weight loss among a sample of bariatric surgery patients with super-super obesity. OBJECTIVE: Previous research implies that persons with presurgical super-super obesity (body mass index [BMI] ≥60 kg/m(2)) tend to have poorer loss outcomes compared with those with a lower presurgical BMI after bariatric surgery. SETTING: Cleveland Clinic, Bariatric & Metabolic Institute, Cleveland, OH...
September 14, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28991597/protective-factors-of-demoralization-among-cancer-patients-in-taiwan-an-age-matched-and-gender-matched-study
#11
Yu-Chi Li, Chung-Han Ho, Hsiu-Hung Wang
PURPOSE: This study aimed to explore the protective factors of demoralization in cancer patients via investigation of cancer patients' demographic and disease characteristics. METHODS: This was a cross-sectional descriptive study. We used a structured questionnaire, which contained items on demographic and disease characteristics, as well as the Demoralization Scale Mandarin Version (DS-MV), with a cutoff of 30 or more indicating high demoralization. Data were analyzed with age-matched and gender-matched conditional logistic regression analysis...
September 2017: Asian Nursing Research
https://www.readbyqxmd.com/read/28960534/factors-associated-with-demoralization-syndrome-in-patients-before-and-after-cardiac-surgery
#12
Hsiu-Yun Liao, Chaw-Chi Chiu, Ying-Ying Ko, Hsing-Mei Chen
AIMS AND OBJECTIVES: This paper sought to investigate the incidence of and contributors to demoralization syndrome among patients before and after cardiac surgery. BACKGROUND: Demoralization syndrome is a common but neglected phenomenon in nursing practice. Patients who require cardiac surgery experience demoralization syndrome more often than they experience depression. DESIGN: A prospective correlational design was applied. METHODS: A convenience sample of 76 participants undergoing cardiac surgery was recruited from the cardiovascular wards of two medical centres in Taiwan...
September 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28932053/management-of-squamous-cell-carcinoma-of-the-maxillary-sinus
#13
Kanva Ramasanjeevaiah Jnanadev, H S Sheethal, H S Suraj, K B Rudresh
Surgical management of malignant tumors disfigures and demoralizes individuals. Management of such patients requires concern humane approach, meticulous planning and judicious management of a case. It is the responsibility of a dentist to restore the lost function, speech and esthetics. This clinical case report signifies the role of the dentist starting from diagnosis, presurgical phase, surgical phase and postsurgical phase of a patient diagnosed with squamous cell carcinoma of the right maxilla.
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28840375/frizzled-5-a-high-affinity-receptor-for-secreted-frizzled-related-protein-2-activation-of-nuclear-factor-of-activated-t-cells-c3-signaling-to-promote-angiogenesis
#14
Yuri K Peterson, Patrick Nasarre, Ingrid V Bonilla, Eleanor Hilliard, Jennifer Samples, Thomas A Morinelli, Elizabeth G Hill, Nancy Klauber-DeMore
Secreted frizzled-related protein 2 (SFRP2) is a pro-angiogenic factor expressed in the vasculature of a wide variety of human tumors, and modulates angiogenesis via the calcineurin-dependent nuclear factor of activated T-cells cytoplasmic 3 (NFATc3) pathway in endothelial cells. However, until now, SFRP2 receptor for this pathway was unknown. In the present study, we first used amino acid alignments and molecular modeling to demonstrate that SFRP2 interaction with frizzled-5 (FZD5) is typical of Wnt/FZD family members...
November 2017: Angiogenesis
https://www.readbyqxmd.com/read/28801849/bevacizumab-in-colorectal-cancer-current-role-in-treatment-and-the-potential-of-biosimilars
#15
REVIEW
Lee S Rosen, Ira A Jacobs, Ronald L Burkes
Colorectal cancer (CRC) is a leading cause of tumor-related morbidity and mortality worldwide, with mortality most often attributable to metastatic disease. Bevacizumab, a humanized monoclonal antibody targeting vascular endothelial growth factor, has a significant role in the treatment of metastatic CRC (mCRC). However, patient access to bevacizumab may be limited in some regions or circumstances, owing to factors related to insurance coverage, reimbursement, patient out-of-pocket costs, or availability. As a result, outcomes for patients with mCRC may be worsened...
October 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28789725/demoralization-in-medical-illness-feasibility-and-acceptability-of-a-pilot-educational-intervention-for-inpatient-oncology-nurses
#16
Benjamin W Brewer, Jennifer M Caspari, Jean Youngwerth, Leigh Nathan, Izaskun Ripoll, Alison Heru
OBJECTIVE: Demoralization is a common problem among medical inpatients with such serious health problems as cancer. An awareness of this syndrome, a knowledge of what defines it, and a plan for how to intervene are limited among nursing teams. Nurses are uniquely poised to efficiently provide brief interventions that address demoralization in their patients. To our knowledge, there are no interventions that train nurses to distinguish and treat demoralization in their patients. The objective of the present study was to determine the acceptability, feasibility, and impact of a novel educational intervention for nurses...
August 9, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28756579/evaluation-of-effects-of-an-operational-multidisciplinary-team-on-antibiotic-use-in-the-medium-to-long-term-at-a-french-university-hospital
#17
Béatrice Demoré, Pauline Humbert, Emmanuelle Boschetti, Sibylle Bevilacqua, Isabelle Clerc-Urmès, Thierry May, Céline Pulcini, Nathalie Thilly
Background Antibiotic-resistant bacteria are a major public health problem throughout the world. In 2006, in accordance with the national guidelines for antibiotic use, the CHRU of Nancy created an operational multidisciplinary antibiotic team at one of its sites. In 2011, a cluster-controlled trial showed that the operational multidisciplinary antibiotic team (the intervention) had a favourable short-term effect on antibiotic use and costs. Objective Our objective was to determine whether these effects continued over the medium to long term (that is, 2-7 years after creation of the operational multidisciplinary antibiotic team, 2009-2014)...
October 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28753076/the-burden-of-psychosocial-morbidity-related-to-cancer-patient-and-family-issues
#18
Rosangela Caruso, Mara Giulia Nanni, Michelle B Riba, Silvana Sabato, Luigi Grassi
With cancer incidence increasing over time, attention to the burden of related psychiatric and psychosocial consequences of the disease and treatment is a major topic for both cancer patients and their caregivers. Among cancer patients, psychiatric (e.g. adjustment, anxiety, depressive disorders) and neuropsychiatric disorders (e.g. cognitive disorders secondary to treatment, delirium) have been shown to affect an average of 30-35% patients, with differences according to stage and type of cancer. Also other psychosocial syndromes (e...
July 28, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28752229/hope-modules-brief-psychotherapeutic-interventions-to-counter-demoralization-from-daily-stressors-of-chronic-illness
#19
James L Griffith
No abstract text is available yet for this article.
July 27, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28719923/-breaking-bad-news-to-cancer-patients-content-communication-preferences-and-psychological-distress
#20
Claudia Gebhardt, Claudia Gorba, Karin Oechsle, Sigrun Vehling, Uwe Koch, Anja Mehnert
Objectives Breaking bad news can be a very distressing situation for both patients and physicians. Physician communication behavior should therefore match patients' communication preferences. The aim of this study was to characterize the content of bad news from the patients' perspective. Patients' preferences for communication of bad news as well as the fit to communication behavior displayed by physicians were also investigated. Finally, consequences of a mismatch between patients' preferences and physician communication were investigated in relation to psychological distress in patients...
July 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
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