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https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#1
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28299710/high-resolution-microultrasound-%C3%AE-us-investigation-of-the-gastrointestinal-gi-tract
#2
Thineskrishna Anbarasan, Christine E M Démoré, Holly Lay, Mohammed R S Sunoqrot, Romans Poltarjonoks, Sandy Cochran, Benjamin F Cox
High resolution, microultrasound (μUS) scanning of the gastrointestinal (GI) tract has potential as an important transmural imaging modality to aid in diagnosis. Operating at higher frequencies than conventional clinical ultrasound instruments, μUS is capable of providing scanned images of the GI tract with higher resolution. To investigate the use of μUS for this application, a phantom which is cost effective, within ethical guidelines and, most importantly, similar in histology to the human GI tract is necessary...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28279121/high-demoralization-in-a-minority-of-oophorectomized-brca1-2-mutation-carriers-influences-quality-of-life
#3
Marieke Arts-de Jong, Cor A J DeJong, Rosella P Hermens, David W Kissane, Leon M Massuger, Nicoline Hoogerbrugge, Judith B Prins, Joanne A deHullu
INTRODUCTION: Demoralization is a relatively neglected issue in which low morale and poor coping result from a stressor such as familial cancer risk. Female BRCA1/2 mutation carriers are highly susceptible for developing breast and ovarian cancer. The aim of this study was to evaluate demoralization in oophorectomized BRCA1/2 mutation carriers and its relation to quality of life. METHODS: This cross-sectional study examined 288 oophorectomized BRCA1/2 mutation carriers using the following standardized self-report measures: Demoralization Scale, EORTC Quality of Life Questionnaire-C30, State-Trait Anxiety Inventory and the Cancer Worry Scale...
March 10, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28265859/new-cancer-pain-treatment-options
#4
REVIEW
Kenneth D Candido, Teresa M Kusper, Nebojsa Nick Knezevic
PURPOSE OF REVIEW: Cancer pain is often incapacitating and discouraging to patients; is demoralizing to family members and care takers; and is taxing and difficult to subdue for the pain specialists. The consequences of implementing suboptimal treatment are far-reaching; therefore, effective treatment methods are in a great demand. The face of cancer pain management has changed in considerable ways, and interventional procedures have become an integral part of providing multimodal analgesia in cancer pain treatment...
February 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28263003/the-factor-structure-and-use-of-the-demoralization-scale-ds-it-in-italian-cancer-patients
#5
Luigi Grassi, Anna Costantini, David Kissane, Serena Brunetti, Rosangela Caruso, Giulia Piazza, Paolo Marchetti, Silvana Sabato, Maria Giulia Nanni
BACKGROUND: Demoralization is a commonly observed syndrome in cancer patients, deserving to be carefully assessed in cross-cultural contexts. AIMS: To examine the factor structure, concurrent and divergent validity of the Italian version of the Demoralization Scale (DS-IT) in cancer patients. METHODS: The sample included 194 Italian cancer outpatients who were assessed by using the DS-IT and the Diagnostic Criteria of Psychosomatic Research-demoralization module (DCPR/D) to examine demoralization...
March 6, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28255855/meeting-disorders
#6
Joel Yager, Jeffrey W Katzman
OBJECTIVE: Although meetings are central to organizational work, considerable time devoted to meetings in Academic Health Centers appears to be unproductively spent. The primary purposes of this article are to delineate and describe Meeting Disorders, pathological processes resulting in these inefficient and ineffective scenarios, and Meeting Fatigue Disorder (MFD), a clinical syndrome. The paper also offers preliminary approaches to remedies. METHODS: The authors integrate observations made during tens of thousands of hours in administrative meetings in academic medical settings with information in the literature regarding the nature, causes and potential interventions for dysfunctional groups and meetings...
March 2, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28166861/effect-of-dignity-therapy-on-end-of-life-psychological-distress-in-terminally-ill-portuguese-patients-a-randomized-controlled-trial
#7
Miguel Julião, Fátima Oliveira, Baltazar Nunes, António Vaz Carneiro, António Barbosa
OBJECTIVE: Dignity therapy (DT) is a brief form of psychotherapy developed for patients living with a life-limiting illness that has demonstrated efficacy in treating several dimensions of end-of-life psychological distress. Our aim was to determine the influence of DT on demoralization syndrome (DS), the desire for death (DfD), and a sense of dignity (SoD) in terminally ill inpatients experiencing a high level of distress in a palliative care unit. METHOD: A nonblinded phase II randomized controlled trial was conducted with 80 patients who were randomly assigned to one of two groups: the intervention group (DT + standard palliative care [SPC]) or the control group (SPC alone)...
February 7, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28150259/-the-relationship-between-pain-and-demoralization-in-cancer-patients
#8
Chia-Hui Lin, Chih-Tsan Wang
BACKGROUND: While patients with cancer commonly experience bodily pain, their perceptions of this pain may differ. Continually experiencing pain elicits a sense of helplessness and pessimism in these patients and exacerbates their perception of interpersonal alienation, which may cause the demoralization syndrome. In Taiwan, the rate of demoralization among patients with cancer is substantially higher than that in other countries. PURPOSE: The meaning of cancer pain is used as the mediating variable to investigate the relationship between the pain that is experienced by patients with cancer and their demoralization...
February 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28129100/demoralization-in-patients-with-substance-use-and-co-occurring-psychiatric-disorders
#9
Gerdien H De Weert-Van Oene, Wiebren Markus, David W Kissane, Cornelis A J De Jong
OBJECTIVE: In recent years, treatment of patients with substance use disorder has rekindled emphasis on recovery which, being a gradual process, starts with remoralization. In this study, we examine the level of demoralization throughout the treatment process for patients with comorbid substance dependence and psychiatric disorders. METHODS: 217 patients with co-occurring disorders and 179 community based individuals participated in this study. Demoralization was measured twice over one month as inpatient treatment happened...
January 27, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28125252/change-in-self-reported-personality-during-major-depressive-disorder-treatment-a-reanalysis-of-treatment-studies-from-a-demoralization-perspective
#10
Arjen Noordhof, Jan H Kamphuis, Martin Sellbom, Annemarie Eigenhuis, R Michael Bagby
Change in self-reported personality trait scores (especially Neuroticism and Extraversion) over the course of treatment for major depressive disorder (MDD) has been robustly demonstrated. We believe that these observed changes on personality trait scales may reflect reduction in demoralization rather than changes in personality per se. Data were combined from 3 archival samples: a randomized clinical trial and 2 naturalistic follow-up studies. All participants (N = 300) received either psychotherapy or psychopharmacological treatment...
January 26, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28118208/from-vitality-to-vital-exhaustion-and-other-states-of-tense-tiredness-a-new-biopsychosocial-risk-domain
#11
Alan Rozanski, Randy Cohen
Fatigue is a common prodromal symptom for various medical conditions, including acute myocardial infarction. Fatigue is also the core component of vital exhaustion, which consists of a specific triad: excessive fatigue, increased irritability, and feelings of demoralization. In this issue of Psychosomatic Medicine, Frestad and Prescott present a meta-analysis of 16 studies, involving 53,337 participants, which found vital exhaustion to be associated with an increased risk of incident coronary heart disease (CHD) and recurrent cardiac events among individuals with established CHD...
January 23, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28110051/reliability-of-self-reported-recent-antibiotic-use-among-the-general-population-a-cross-sectional-study
#12
B Demoré, D Le Govic, N Thilly, J-M Boivin, C Pulcini
OBJECTIVES: This study aimed at evaluating the reliability of self-reported recent antibiotic use, including ability to name the antibiotic, among pharmacy customers from the general population. METHODS: This cross-sectional observational study of adults took place in pharmacies in northeastern France from January to April 2016. Participants were asked if they had used any antibiotics in the preceding 4 months and if so, to name them. Their reports were compared with an electronic pharmacy dispensing record listing all of the medication dispensed to them in France...
January 19, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28065203/the-short-demoralization-scale-sds-a-new-tool-to-appraise-demoralization-in-palliative-care-patients
#13
Laura Galiana, David Rudilla, Amparo Oliver, Pilar Barreto
OBJECTIVE: The Demoralization Scale (DS) is the most widely used measure for assessing demoralization. Following the recent clamor for brief assessment tools, and taking into account that demoralization has proved to be a symptom that needs to be controlled and treated in the palliative care setting, a shorter scale is needed. The aim of the present research is to introduce and evaluate the Short Demoralization Scale (SDS). METHOD: We employed a cross-sectional design that included a survey of 226 Spanish palliative care patients from the Hospital General Universitario de Valencia...
January 9, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28045883/healing-through-words-jerome-frank-and-psychotherapy-at-johns-hopkins-the-phipps-centennial-lectures-the-jerome-frank-lecture
#14
Kay Redfield Jamison
This lecture, given to celebrate the centenary of the founding of the Henry Phipps Psychiatric Service at Johns Hopkins, focuses on the contributions of Jerome Frank to the understanding and practice of psychotherapy. It gives an overview of Professor Frank's ideas and work, puts them into the context of the history of psychotherapy research at Johns Hopkins, and discusses psychotherapy and demoralization in bipolar illness.
December 30, 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27909164/rapid-and-sustained-symptom-reduction-following-psilocybin-treatment-for-anxiety-and-depression-in-patients-with-life-threatening-cancer-a-randomized-controlled-trial
#15
Stephen Ross, Anthony Bossis, Jeffrey Guss, Gabrielle Agin-Liebes, Tara Malone, Barry Cohen, Sarah E Mennenga, Alexander Belser, Krystallia Kalliontzi, James Babb, Zhe Su, Patricia Corby, Brian L Schmidt
BACKGROUND: Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression. METHODS: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0...
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27897312/the-feasibility-of-micro-ultrasound-as-a-tool-to-image-peripheral-nerves
#16
A Chandra, R Eisma, P Felts, S Munirama, G A Corner, C E M Demore, G McLeod
Despite widespread use of ultrasound imaging to guide needle placement, the incidence of transient and permanent nerve damage as a complication of regional anaesthesia has not changed over the last decade. In view of the controversy surrounding intraneural injection there is a need to understand the structural changes caused by subepineural and subperineural needle penetration. Clinical ultrasound machines do not provide adequate anatomical resolution, and anaesthetists have difficulty judging the precise location of the needle tip relative to the epineurium...
November 29, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27884039/clarifying-the-links-of-conscientiousness-with-internalizing-and-externalizing-psychopathology
#17
Kristin Naragon-Gainey, Leonard J Simms
OBJECTIVE: Although Conscientiousness/disinhibition plays a substantial role in internalizing and externalizing psychopathology, the underlying mechanisms are not well understood. We aim to clarify facet-level associations and to examine whether (a) impairment mediates the link of Conscientiousness with internalizing and externalizing symptoms, and (b) demoralization (assessed via Neuroticism) accounts for their associations. METHOD: A total of 450 participants (Mage  = 42; primarily female and Caucasian) who reported current/recent psychiatric treatment completed two measures of domain- and facet-level traits (i...
November 24, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27884006/current-psychosomatic-practice
#18
Giovanni A Fava, Fiammetta Cosci, Nicoletta Sonino
Psychosomatic research has advanced over the past decades in dealing with complex biopsychosocial phenomena and may provide new effective modalities of patient care. Among psychosocial variables affecting individual vulnerability, course, and outcome of any medical disease, the role of chronic stress (allostatic load/overload) has emerged as a crucial factor. Assessment strategies include the Diagnostic Criteria for Psychosomatic Research. They are presented here in an updated version based on insights derived from studies carried out so far and encompass allostatic overload, type A behavior, alexithymia, the spectrum of maladaptive illness behavior, demoralization, irritable mood, and somatic symptoms secondary to a psychiatric disorder...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27878884/development-of-the-chinese-version-of-meaning-in-life-scale-for-cancer-patients-and-psychometric-evaluation
#19
Hao-Zhi Xia, Lei Gao, Yang Wang, Hui Song, Bao-Xin Shi
AIMS AND OBJECTIVES: To develop a Meaning in Life Scale for cancer patients in Chinese version and to test the validity and reliability. BACKGROUND: Meaning in life is a protective factor of psychological well-being and is negatively related to depression and demoralisation among cancer patients. The existing scales measuring meaning in life are mostly designed in English and there is no scale designed for Chinese cancer patients based on Chinese cultural background...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27854104/new-practical-approaches-to-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment
#20
REVIEW
Neil Majithia, Charles L Loprinzi, Thomas J Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program. Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to...
November 15, 2016: Oncology (Williston Park, NY)
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