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Frank B Hu

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https://www.readbyqxmd.com/read/29219149/global-aetiology-and-epidemiology-of-type-2-diabetes-mellitus-and-its-complications
#1
REVIEW
Yan Zheng, Sylvia H Ley, Frank B Hu
Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life...
December 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29212779/longitudinal-analysis-of-genetic-susceptibility-and-body-mass-index-throughout-adult-life
#2
Mingyang Song, Yan Zheng, Lu Qi, Frank B Hu, Andrew T Chan, Edward L Giovannucci
Little is known about the genetic influence on body mass index (BMI) trajectory throughout adulthood. We created a genetic risk score (GRS) comprising 97 adult BMI-associated variants among 9,971 women and 6,405 men of European ancestry. Serial measures of BMI were assessed from ages 18 (women) or 21 (men) to 85 years. We also examined BMI change in early (from age 18 or 21 to 45), middle (from age 45 to 65), and late adulthood (from age 65 to 80). GRS was positively associated with BMI across all ages, with stronger associations in women than in men...
December 6, 2017: Diabetes
https://www.readbyqxmd.com/read/29211904/associations-between-genetic-variants-associated-with-body-mass-index-and-trajectories-of-body-fatness-across-the-life-course-a-longitudinal-analysis
#3
Mingyang Song, Yan Zheng, Lu Qi, Frank B Hu, Andrew T Chan, Edward L Giovannucci
Background: The genetic associations with trajectories of body fatness over the life course remain unknown. Methods: We used a group-based modelling approach to identify trajectories of body fatness from age 5 years up to 65 for 7277 women from the Nurses' Health Study and 4645 men from the Health Professionals Follow-up Study. We created a genetic risk score (GRS) based on 97 variants associated with adulthood body mass index (BMI) and estimated its association with trajectories using logistic regression...
December 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29206988/group-based-trajectory-of-body-shape-from-ages-5-to-55-years-and-cardiometabolic-disease-risk-in-2-us-cohorts
#4
Yan Zheng, Mingyang Song, JoAnn E Manson, Edward L Giovannucci, Frank B Hu
The association of adiposity across the life span with cardiometabolic risk is not completely delineated. We used a group-based modeling approach to identify distinct trajectories of body shape from ages 5 years to 55 years among 84,792 women from the Nurses' Health Study (1976-2010) and 37,706 men from the Health Professionals Follow-up Study (1986-2010) and assessed the associations between these trajectories and incidence of type 2 diabetes and cardiovascular disease (CVD) during a 17-year follow-up period...
December 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29158191/association-between-coffee-intake-after-diagnosis-of-colorectal-cancer-and-reduced-mortality
#5
Yang Hu, Ming Ding, Chen Yuan, Kana Wu, Stephanie A Smith-Warner, Frank B Hu, Andrew T Chan, Jeffrey A Meyerhardt, Shuji Ogino, Charles S Fuchs, Edward L Giovannucci, Mingyang Song
BACKGROUND & AIMS: Few studies have examined the association between coffee intake and survival after diagnosis of colorectal cancer (CRC). We performed a prospective study to investigate the association between coffee intake after a diagnosis of CRC and mortality. METHODS: We collected data from the Nurses' Health Study (1984-2012) and Health Professionals Follow-up Study (1986-2012), following 1599 patients diagnosed with stage 1 or 2 CRC. CRC was reported on questionnaires and ascertained by review of medical records and pathology reports; intake of food and beverages was determined from responses to semi-quantitative food frequency questionnaires...
November 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29145952/nut-consumption-and-risk-of-cardiovascular-disease
#6
MULTICENTER STUDY
Marta Guasch-Ferré, Xiaoran Liu, Vasanti S Malik, Qi Sun, Walter C Willett, JoAnn E Manson, Kathryn M Rexrode, Yanping Li, Frank B Hu, Shilpa N Bhupathiraju
BACKGROUND: The associations between specific types of nuts, specifically peanuts and walnuts, and cardiovascular disease remain unclear. OBJECTIVES: The authors sought to analyze the associations between the intake of total and specific types of nuts and cardiovascular disease, coronary heart disease, and stroke risk. METHODS: The authors included 76,364 women from the Nurses' Health Study (1980 to 2012), 92,946 women from the Nurses' Health Study II (1991 to 2013), and 41,526 men from the Health Professionals Follow-Up Study (1986 to 2012) who were free of cancer, heart disease, and stroke at baseline...
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29140419/dietary-glutamine-glutamate-and-mortality-two-large-prospective-studies-in-us-men-and-women
#7
Wenjie Ma, Yoriko Heianza, Tao Huang, Tiange Wang, Dianjianyi Sun, Yan Zheng, Frank B Hu, Kathryn M Rexrode, JoAnn E Manson, Lu Qi
Background: Emerging studies have related circulating glutamine metabolites to various chronic diseases such as cardiovascular disease and cancer; diet is the major source of nutrients involved in glutamine metabolism. However, it remains unknown whether dietary intakes of glutamine, glutamate,and their ratio are related to total and cause-specific mortality. Methods: We followed 74 082 women from the Nurses' Health Study (1984-2012) and 42 303 men from the Health Professionals Follow-up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline...
November 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29127271/whole-grain-consumption-and-risk-of-ischemic-stroke-results-from-2-prospective-cohort-studies
#8
Juan Juan, Gang Liu, Walter C Willett, Frank B Hu, Kathryn M Rexrode, Qi Sun
BACKGROUND AND PURPOSE: Higher intake of whole grains may exert cardiometabolic benefits, although findings on stroke risk are inconclusive. The potentially differential effects of individual whole grain foods on ischemic stroke have not been examined. METHODS: We analyzed whole grain consumption in relation to ischemic stroke among 71 750 women from the Nurses' Health Study and 42 823 men from the Health Professionals Follow-up Study who were free of cardiovascular disease, diabetes mellitus, and cancer at baseline (1984 and 1986, respectively) through 2010 using a Cox proportional hazards model...
November 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29110742/development-and-validation-of-anthropometric-prediction-equations-for-lean-body-mass-fat-mass-and-percent-fat-in-adults-using-the-national-health-and-nutrition-examination-survey-nhanes-1999-2006
#9
Dong Hoon Lee, NaNa Keum, Frank B Hu, E John Orav, Eric B Rimm, Qi Sun, Walter C Willett, Edward L Giovannucci
Quantification of lean body mass and fat mass can provide important insight into epidemiological research. However, there is no consensus on generalisable anthropometric prediction equations to validly estimate body composition. We aimed to develop and validate practical anthropometric prediction equations for lean body mass, fat mass and percent fat in adults (men, n 7531; women, n 6534) from the National Health and Nutrition Examination Survey 1999-2006. Using a prediction sample, we predicted each of dual-energy X-ray absorptiometry (DXA)-measured lean body mass, fat mass and percent fat based on different combinations of anthropometric measures...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29097515/adiposity-and-genetic-factors-in-relation-to-triglycerides-and-triglyceride-rich-lipoproteins-in-the-women-s-genome-health-study
#10
Shafqat Ahmad, Samia Mora, Paul W Franks, Marju Orho-Melander, Paul M Ridker, Frank B Hu, Daniel I Chasman
BACKGROUND: Previous results from Scandinavian cohorts have shown that obesity accentuates the effects of common genetic susceptibility variants on increased tri-glycerides (TG). Whether such interactions are present in the US population and further selective for particular TG-rich lipoprotein subfractions is unknown. METHODS: We examined these questions using body mass index (BMI) and waist circumference (WC) among women of European ancestry from the Women's Genome Health Study (WGHS) (n = 21840 for BMI; n = 19313 for WC)...
November 2, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29097389/duration-of-reproductive-life-span-age-at-menarche-and-age-at-menopause-are-associated-with-risk-of-cardiovascular-disease-in-women
#11
Sylvia H Ley, Yanping Li, Deirdre K Tobias, JoAnn E Manson, Bernard Rosner, Frank B Hu, Kathryn M Rexrode
BACKGROUND: Although the timing of menarche and menopause may be associated with cardiovascular disease (CVD), the entire reproductive life span has not been considered comprehensively as risk for CVD. We investigate the associations of reproductive life span duration and ages at menarche and menopause, induced by natural means or surgical bilateral oophorectomy, with incident CVD in women. METHODS AND RESULTS: Prospective cohort study of 73 814 Nurses' Health Study following participants without CVD, defined as incident coronary heart disease or stroke, from 1980 through 2012...
November 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29080862/plasma-metabolites-from-choline-pathway-and-risk-of-cardiovascular-disease-in-the-predimed-prevention-with-mediterranean-diet-study
#12
Marta Guasch-Ferré, Frank B Hu, Miguel Ruiz-Canela, Mònica Bulló, Estefanía Toledo, Dong D Wang, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramon Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Emilio Ros, Courtney Dennis, Liming Liang, Clary B Clish, Miguel A Martínez-González, Jordi Salas-Salvadó
BACKGROUND: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. METHODS AND RESULTS: We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29064788/plasma-metal-concentrations-and-incident-coronary-heart-disease-in-chinese-adults-the-dongfeng-tongji-cohort
#13
Yu Yuan, Yang Xiao, Wei Feng, Yiyi Liu, Yanqiu Yu, Lue Zhou, Gaokun Qiu, Hao Wang, Bing Liu, Kang Liu, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Chengwei Xu, Xiaomin Zhang, Meian He, Frank B Hu, An Pan, Tangchun Wu
BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex...
October 19, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29049820/association-of-history-of-gestational-diabetes-with-long-term-cardiovascular-disease-risk-in-a-large-prospective-cohort-of-us-women
#14
Deirdre K Tobias, Jennifer J Stuart, Shanshan Li, Jorge Chavarro, Eric B Rimm, Janet Rich-Edwards, Frank B Hu, JoAnn E Manson, Cuilin Zhang
Importance: Previous studies identify gestational diabetes (GD) as a risk factor for intermediate markers of cardiovascular disease (CVD) risk; however, few are prospective, evaluate hard CVD end points, or account for shared risk factors including body weight and lifestyle. Objective: To prospectively evaluate history of GD in relation to incident CVD risk. Design, Setting, and Participants: The Nurses' Health Study II (NHS II) is an observational cohort study of US female nurses established in 1989, with ongoing follow-up...
December 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29046327/time-trends-of-dietary-and-lifestyle-factors-and-their-potential-impact-on-diabetes-burden-in-china
#15
Yanping Li, Dong D Wang, Sylvia H Ley, Malik Vasanti, Annie Green Howard, Yuna He, Frank B Hu
OBJECTIVE: To examine the secular trends in risk factors, estimate their impact on type 2 diabetes burden from 1991 to 2011, and project trends in the next 20 years. RESEARCH DESIGN AND METHODS: Risk factor distributions were based on data from the China Health and Nutrition Survey 1991-2011. Diabetes cases attributable to all nonoptimal levels of each risk factor were estimated by applying the comparative risk assessment method. RESULTS: In 2011, high BMI was the leading individual attributable factor for diabetes cases in China responsible for 43...
October 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038315/adiposity-dysmetabolic-traits-and-earlier-onset-of-female-puberty-in-adolescent-offspring-of-women-with-gestational-diabetes-mellitus-a-clinical-study-within-the-danish-national-birth-cohort
#16
Louise G Grunnet, Susanne Hansen, Line Hjort, Camilla M Madsen, Freja B Kampmann, Anne Cathrine B Thuesen, Charlotta Granstrømi, Marin Strøm, Ekaterina Maslova, Ruth Frikke-Schmidt, Peter Damm, Jorge E Chavarro, Frank B Hu, Sjurdur F Olsen, Allan Vaag
OBJECTIVE: Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS: We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipids levels; and conducted a DEXA scan in a subset of the cohort...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038146/use-of-metabolomics-in-improving-assessment-of-dietary-intake
#17
REVIEW
Marta Guasch-Ferré, Shilpa N Bhupathiraju, Frank B Hu
BACKGROUND: Nutritional metabolomics is rapidly evolving to integrate nutrition with complex metabolomics data to discover new biomarkers of nutritional exposure and status. CONTENT: The purpose of this review is to provide a broad overview of the measurement techniques, study designs, and statistical approaches used in nutrition metabolomics, as well as to describe the current knowledge from epidemiologic studies identifying metabolite profiles associated with the intake of individual nutrients, foods, and dietary patterns...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29032079/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled-analysis-of-individual-level-data-for-39%C3%A2-740-adults-from-20-prospective-cohort-studies
#18
Jason H Y Wu, Matti Marklund, Fumiaki Imamura, Nathan Tintle, Andres V Ardisson Korat, Janette de Goede, Xia Zhou, Wei-Sin Yang, Marcia C de Oliveira Otto, Janine Kröger, Waqas Qureshi, Jyrki K Virtanen, Julie K Bassett, Alexis C Frazier-Wood, Maria Lankinen, Rachel A Murphy, Kalina Rajaobelina, Liana C Del Gobbo, Nita G Forouhi, Robert Luben, Kay-Tee Khaw, Nick Wareham, Anya Kalsbeek, Jenna Veenstra, Juhua Luo, Frank B Hu, Hung-Ju Lin, David S Siscovick, Heiner Boeing, Tzu-An Chen, Brian Steffen, Lyn M Steffen, Allison Hodge, Gudny Eriksdottir, Albert V Smith, Vilmunder Gudnason, Tamara B Harris, Ingeborg A Brouwer, Claudine Berr, Catherine Helmer, Cecilia Samieri, Markku Laakso, Michael Y Tsai, Graham G Giles, Tarja Nurmi, Lynne Wagenknecht, Matthias B Schulze, Rozenn N Lemaitre, Kuo-Liong Chien, Sabita S Soedamah-Muthu, Johanna M Geleijnse, Qi Sun, William S Harris, Lars Lind, Johan Ärnlöv, Ulf Riserus, Renata Micha, Dariush Mozaffarian
BACKGROUND: The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. METHODS: We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes...
October 11, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29025133/offspring-risk-of-obesity-in-childhood-adolescence-and-adulthood-in-relation-to-gestational-diabetes-mellitus-a-sex-specific-association
#19
Shanshan Li, Yeyi Zhu, Edwina Yeung, Jorge E Chavarro, Changzheng Yuan, Alison E Field, Stacey A Missmer, James L Mills, Frank B Hu, Cuilin Zhang
No abstract text is available yet for this article.
September 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024955/offspring-risk-of-obesity-in-childhood-adolescence-and-adulthood-in-relation-to-gestational-diabetes-mellitus-a-sex-specific-association
#20
Shanshan Li, Yeyi Zhu, Edwina Yeung, Jorge E Chavarro, Changzheng Yuan, Alison E Field, Stacey A Missmer, James L Mills, Frank B Hu, Cuilin Zhang
Background: Animal data suggest sexually dimorphic programming of obesity in response to altered intrauterine environment, but the longitudinal impact of gestational diabetes mellitus (GDM) on sex-specific risk of offspring obesity in humans is unclear. Methods: We conducted a prospective analysis of 15 009 US individuals (7946 female and 7063 male) from the Growing-Up Today Study, who were followed from 1996 (ages 9-14 years) through 2010. Height and weight from validated questionnaires were used to derive body mass index (BMI) at different ages...
October 1, 2017: International Journal of Epidemiology
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