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Frank B Hu

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https://www.readbyqxmd.com/read/29049820/association-of-history-of-gestational-diabetes-with-long-term-cardiovascular-disease-risk-in-a-large-prospective-cohort-of-us-women
#1
Deirdre K Tobias, Jennifer J Stuart, Shanshan Li, Jorge Chavarro, Eric B Rimm, Janet Rich-Edwards, Frank B Hu, JoAnn E Manson, Cuilin Zhang
Importance: Previous studies identify gestational diabetes (GD) as a risk factor for intermediate markers of cardiovascular disease (CVD) risk; however, few are prospective, evaluate hard CVD end points, or account for shared risk factors including body weight and lifestyle. Objective: To prospectively evaluate history of GD in relation to incident CVD risk. Design, Setting, and Participants: The Nurses' Health Study II (NHS II) is an observational cohort study of US female nurses established in 1989, with ongoing follow-up...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29046327/time-trends-of-dietary-and-lifestyle-factors-and-their-potential-impact-on-diabetes-burden-in-china
#2
Yanping Li, Dong D Wang, Sylvia H Ley, Malik Vasanti, Annie Green Howard, Yuna He, Frank B Hu
OBJECTIVE: To examine the secular trends in risk factors, estimate their impact on type 2 diabetes burden from 1991 to 2011, and project trends in the next 20 years. RESEARCH DESIGN AND METHODS: Risk factor distributions were based on data from the China Health and Nutrition Survey 1991-2011. Diabetes cases attributable to all nonoptimal levels of each risk factor were estimated by applying the comparative risk assessment method. RESULTS: In 2011, high BMI was the leading individual attributable factor for diabetes cases in China responsible for 43...
October 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038315/adiposity-dysmetabolic-traits-and-earlier-onset-of-female-puberty-in-adolescent-offspring-of-women-with-gestational-diabetes-mellitus-a-clinical-study-within-the-danish-national-birth-cohort
#3
Louise G Grunnet, Susanne Hansen, Line Hjort, Camilla M Madsen, Freja B Kampmann, Anne Cathrine B Thuesen, Charlotta Granstrømi, Marin Strøm, Ekaterina Maslova, Ruth Frikke-Schmidt, Peter Damm, Jorge E Chavarro, Frank B Hu, Sjurdur F Olsen, Allan Vaag
OBJECTIVE: Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS: We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipids levels; and conducted a DEXA scan in a subset of the cohort...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038146/use-of-metabolomics-in-improving-assessment-of-dietary-intake
#4
REVIEW
Marta Guasch-Ferré, Shilpa N Bhupathiraju, Frank B Hu
BACKGROUND: Nutritional metabolomics is rapidly evolving to integrate nutrition with complex metabolomics data to discover new biomarkers of nutritional exposure and status. CONTENT: The purpose of this review is to provide a broad overview of the measurement techniques, study designs, and statistical approaches used in nutrition metabolomics, as well as to describe the current knowledge from epidemiologic studies identifying metabolite profiles associated with the intake of individual nutrients, foods, and dietary patterns...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29032079/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled-analysis-of-individual-level-data-for-39%C3%A2-740-adults-from-20-prospective-cohort-studies
#5
Jason H Y Wu, Matti Marklund, Fumiaki Imamura, Nathan Tintle, Andres V Ardisson Korat, Janette de Goede, Xia Zhou, Wei-Sin Yang, Marcia C de Oliveira Otto, Janine Kröger, Waqas Qureshi, Jyrki K Virtanen, Julie K Bassett, Alexis C Frazier-Wood, Maria Lankinen, Rachel A Murphy, Kalina Rajaobelina, Liana C Del Gobbo, Nita G Forouhi, Robert Luben, Kay-Tee Khaw, Nick Wareham, Anya Kalsbeek, Jenna Veenstra, Juhua Luo, Frank B Hu, Hung-Ju Lin, David S Siscovick, Heiner Boeing, Tzu-An Chen, Brian Steffen, Lyn M Steffen, Allison Hodge, Gudny Eriksdottir, Albert V Smith, Vilmunder Gudnason, Tamara B Harris, Ingeborg A Brouwer, Claudine Berr, Catherine Helmer, Cecilia Samieri, Markku Laakso, Michael Y Tsai, Graham G Giles, Tarja Nurmi, Lynne Wagenknecht, Matthias B Schulze, Rozenn N Lemaitre, Kuo-Liong Chien, Sabita S Soedamah-Muthu, Johanna M Geleijnse, Qi Sun, William S Harris, Lars Lind, Johan Ärnlöv, Ulf Riserus, Renata Micha, Dariush Mozaffarian
BACKGROUND: The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. METHODS: We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes...
October 11, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29025133/offspring-risk-of-obesity-in-childhood-adolescence-and-adulthood-in-relation-to-gestational-diabetes-mellitus-a-sex-specific-association
#6
Shanshan Li, Yeyi Zhu, Edwina Yeung, Jorge E Chavarro, Changzheng Yuan, Alison E Field, Stacey A Missmer, James L Mills, Frank B Hu, Cuilin Zhang
No abstract text is available yet for this article.
September 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024955/offspring-risk-of-obesity-in-childhood-adolescence-and-adulthood-in-relation-to-gestational-diabetes-mellitus-a-sex-specific-association
#7
Shanshan Li, Yeyi Zhu, Edwina Yeung, Jorge E Chavarro, Changzheng Yuan, Alison E Field, Stacey A Missmer, James L Mills, Frank B Hu, Cuilin Zhang
Background: Animal data suggest sexually dimorphic programming of obesity in response to altered intrauterine environment, but the longitudinal impact of gestational diabetes mellitus (GDM) on sex-specific risk of offspring obesity in humans is unclear. Methods: We conducted a prospective analysis of 15 009 US individuals (7946 female and 7063 male) from the Growing-Up Today Study, who were followed from 1996 (ages 9-14 years) through 2010. Height and weight from validated questionnaires were used to derive body mass index (BMI) at different ages...
August 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29020272/walking-pace-and-handgrip-strength-simple-measures-of-fitness-and-mortality-risk
#8
Anders Grøntved, Frank B Hu
No abstract text is available yet for this article.
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28980000/increased-indoleamine-2-3-dioxygenase-and-quinolinic-acid-expression-in-microglia-and-m%C3%A3-ller-cells-of-diabetic-human-and-rodent-retina
#9
Ping Hu, Nicholas H Hunt, Frank Arfuso, Lynn C Shaw, Mohammad Nasir Uddin, Meidong Zhu, Raj Devasahayam, Samuel J Adamson, Vicky L Benson, Tailoi Chan-Ling, Maria B Grant
Purpose: We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina of rats with T1D. Methods: Retinas from T1D (n = 7), T2D (n = 13), and 20 age-matched nondiabetic human donors and from T1D (n = 3) and control rats (n = 3) were examined using immunohistochemistry for IDO, QUIN, cluster of differentiation 39 (CD39), ionized calcium-binding adaptor molecule (Iba-1, for macrophages and microglia), Vimentin (VIM; for Müller cells), neuronal nuclei (NeuN; for neurons), and UEA1 lectin (for blood vessels)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28978672/magnesium-intake-quality-of-carbohydrates-and-risk-of-type-2-diabetes-results-from-three-u-s-cohorts
#10
Adela Hruby, Marta Guasch-Ferré, Shilpa N Bhupathiraju, JoAnn E Manson, Walter C Willett, Nicola M McKeown, Frank B Hu
OBJECTIVE: Magnesium intake is inversely associated with risk of type 2 diabetes in many observational studies, but few have assessed this association in the context of the carbohydrate quality of the diet. We hypothesized that higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of a poor-carbohydrate-quality diet characterized by low cereal fiber or high glycemic index (GI) or glycemic load (GL). RESEARCH DESIGN AND METHODS: In the Nurses' Health Study (NHS; 1984-2012, n = 69,176), NHS2 (1991-2013, n = 91,471), and the Health Professionals' Follow-Up Study (1986-2012, n = 42,096), dietary intake was assessed from food frequency questionnaires every 4 years...
October 4, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28976079/pre-pregnancy-habitual-intake-of-vitamin-d-from-diet-and-supplements-in-relation-to-risk-of-gestational-diabetes-mellitus-a-prospective-cohort-study
#11
Wei Bao, Yiqing Song, Kimberly A Bertrand, Deirdre K Tobias, Sjurdur F Olsen, Jorge E Chavarro, James L Mills, Frank B Hu, Cuilin Zhang
BACKGROUND: Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the impact of vitamin D intake either from diet or from supplements on the development of gestational diabetes mellitus (GDM) remains unknown. We prospectively examined the association of pre-pregnancy habitual intake of vitamin D from diet and supplements with risk of incident GDM in a well-established cohort. METHODS: We included 21,356 singleton pregnancies from 15,225 women in the Nurses' Health Study II cohort...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28963102/comprehensive-metabolomic-profiling-and-incident-cardiovascular-disease-a-systematic-review
#12
REVIEW
Miguel Ruiz-Canela, Adela Hruby, Clary B Clish, Liming Liang, Miguel A Martínez-González, Frank B Hu
BACKGROUND: Metabolomics is a promising tool of cardiovascular biomarker discovery. We systematically reviewed the literature on comprehensive metabolomic profiling in association with incident cardiovascular disease (CVD). METHODS AND RESULTS: We searched MEDLINE and EMBASE from inception to January 2016. Studies were eligible if they pertained to adult humans; followed an agnostic and/or comprehensive approach; used serum or plasma (not urine or other biospecimens); conducted metabolite profiling at baseline in the context of examining prospective disease; and included myocardial infarction, stroke, and/or CVD death in the CVD outcome definition...
September 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28949355/hierarchical-and-chemical-space-partitioning-in-new-intermetallic-borides-mni21b20-m-in-sn
#13
Frank R Wagner, Qiang Zheng, Roman Gumeniuk, David Bende, Yurii Prots, Matej Bobnar, Dong-Li Hu, Ulrich Burkhardt, Yuri Grin, Andreas Leithe-Jasper
The compounds MNi21B20 (M = In, Sn) have been synthesized and their cubic crystal structure determined (space group Pm3[combining macron]m, lattice parameters a = 7.1730(1) Å and a = 7.1834(1) Å, respectively). The structure can be described as a hierarchical partitioning of space based on a reo-e net formed by Ni3 species with large cubical, cuboctahedral and rhombicuboctahedral voids being filled according to [Ni1@Ni38], [M@Ni312], and [Ni26@B20@Ni324], respectively. The [Ni6@B20] motif inside the rhombicuboctahedral voids features an empty [Ni6] octahedron surrounded by a [B20] cage recently described in E2Ni21B20 (E = Zn, Ga)...
October 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28938710/hormone-therapy-use-and-risk-of-chronic-disease-in-the-nurses-health-study-a-comparative-analysis-with-the-women-s-health-initiative
#14
COMPARATIVE STUDY
Shilpa N Bhupathiraju, Francine Grodstein, Bernard A Rosner, Meir J Stampfer, Frank B Hu, Walter C Willett, JoAnn E Manson
Observational studies and randomized controlled trials of menopausal hormone therapy (HT) and chronic disease risk appear to have divergent results for cardiovascular disease. However, differences may be related to a modifying effect of age, time since menopause, and HT formulation. In the Nurses' Health Study (NHS) (enrolling during 1980-1994 and following participants until 2002), we investigated associations between the use of oral conjugated equine estrogens (CEE) (0.625 mg/day) plus medroxyprogesterone acetate (MPA) (<10 mg/day) or oral CEE alone and cardiovascular disease, cancer, all-cause mortality, and other major endpoints among postmenopausal women, aged 50-79 years at HT initiation...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28888344/plasma-retinol-binding-protein-4-levels-and-the-risk-of-ischemic-stroke-among-women
#15
Pamela M Rist, Monik C Jiménez, Shelley S Tworoger, Frank B Hu, JoAnn E Manson, Qi Sun, Kathryn M Rexrode
BACKGROUND: Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women. METHODS: We performed a nested case-control study among women enrolled in the Nurses' Health Study who provided blood samples between 1989 and 1990 and were free of prior stroke and cancer...
September 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28887409/longitudinal-change-in-fasting-blood-glucose-and-myocardial-infarction-risk-in-a-population-without-diabetes
#16
Cheng Jin, Shuohua Chen, Anand Vaidya, Yuntao Wu, Zhijun Wu, Frank B Hu, Penny Kris-Etherton, Shouling Wu, Xiang Gao
OBJECTIVE: To examine the change in fasting blood glucose (FBG) during repeated assessments over time and its potential impact on the risk of developing myocardial infarction (MI). RESEARCH DESIGN AND METHODS: This prospective cohort study included 68,297 participants without diabetes (mean age 49 years) who were free of MI, stroke, and cancer prior to or in 2010 (baseline of the current analysis). FBG concentrations were measured in 2006, 2008, and 2010. The FBG trajectories during 2006-2010, the primary exposure of the current study, were identified by latent mixture modeling...
September 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28882871/independent-and-synergistic-associations-of-biomarkers-of-vitamin-d-status-with-risk-of-coronary-heart-disease
#17
Lu Qi, Wenjie Ma, Yoriko Heianza, Yan Zheng, Tiange Wang, Dianjianyi Sun, Eric B Rimm, Frank B Hu, Edward Giovannucci, Christine M Albert, Kathryn M Rexrode, JoAnn E Manson
OBJECTIVE: To comprehensively evaluate the independent associations and potential interactions of vitamin D-related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD). APPROACH AND RESULTS: We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses' Health Study during 20 years of follow-up (1990-2010)...
September 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28854932/a-healthy-approach-to-dietary-fats-understanding-the-science-and-taking-action-to-reduce-consumer-confusion
#18
REVIEW
Ann G Liu, Nikki A Ford, Frank B Hu, Kathleen M Zelman, Dariush Mozaffarian, Penny M Kris-Etherton
Consumers are often confused about nutrition research findings and recommendations. As content experts, it is essential that nutrition scientists communicate effectively. A case-study of the history of dietary fat science and recommendations is presented, summarizing presentations from an Experimental Biology Symposium that addressed techniques for effective scientific communication and used the scientific discourse of public understanding of dietary fats and health as an example of challenges in scientific communication...
August 30, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28814398/plasma-lipidomic-profiles-and-cardiovascular-events-in-a-randomized-intervention-trial-with-the-mediterranean-diet
#19
RANDOMIZED CONTROLLED TRIAL
Estefanía Toledo, Dong D Wang, Miguel Ruiz-Canela, Clary B Clish, Cristina Razquin, Yan Zheng, Marta Guasch-Ferré, Adela Hruby, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Luis Serra-Majem, Liming Liang, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]...
October 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28811361/chemoradiotherapy-resistance-in-colorectal-cancer-cells-is-mediated-by-wnt-%C3%AE-catenin-signaling
#20
Georg Emons, Melanie Spitzner, Sebastian Reineke, Janneke Möller, Noam Auslander, Frank Kramer, Yue Hu, Tim Beissbarth, Hendrik A Wolff, Margret Rave-Fränk, Elisabeth Heßmann, Jochen Gaedcke, B Michael Ghadimi, Steven A Johnsen, Thomas Ried, Marian Grade
Activation of Wnt/β-catenin signaling plays a central role in the development and progression of colorectal cancer. The Wnt-transcription factor, TCF7L2, is overexpressed in primary rectal cancers that are resistant to chemoradiotherapy and TCF7L2 mediates resistance to chemoradiotherapy. However, it is unclear whether the resistance is mediated by a TCF7L2 inherent mechanism or Wnt/β-catenin signaling in general. Here, inhibition of β-catenin by siRNAs or a small-molecule inhibitor (XAV-939) resulted in sensitization of colorectal cancer cells to chemoradiotherapy...
August 15, 2017: Molecular Cancer Research: MCR
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