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https://www.readbyqxmd.com/read/28890727/popliteal-artery-entrapment-or-chronic-exertional-compartment-syndrome
#1
Christopher Gaunder, Brandon McKinney, Jessica Rivera
Diagnosis of lower limb pain in an athlete can be a challenging task due to the variety of potential etiologies and ambiguity of presenting symptoms. Five of the most commonly encountered causes of limb pain in athletes are chronic exertional compartment syndrome (CECS), medial tibial stress syndrome (MTSS), tibial stress fractures, soleal sling syndrome, and popliteal artery entrapment syndrome (PAES). Of these, the least frequent but potentially most serious of the pathologies is PAES. With an incidence of less than 1% seen in living subject studies, the condition is rare...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28882773/shockwave-treatment-for-medial-tibial-stress-syndrome-in-military-cadets-a-single-blind-randomized-controlled-trial
#2
Santiago Gomez Garcia, Silvia Ramon Rona, Martha Claudia Gomez Tinoco, Mikhail Benet Rodriguez, Diego Mauricio Chaustre Ruiz, Francia Piedad Cardenas Letrado, África Lopez-Illescas Ruiz, Juan Maria Alarcon Garcia
Medial tibial stress syndrome (MTSS) is a common injury in athletes and soldiers. Several studies have demonstrated the effectiveness of extracorporeal shockwave treatment (ESWT) in athletes with MTSS. OBJECTIVE: To assess whether one session of focused ESWT is effective in the treatment of military cadets with MTSS. DESIGN: A randomized, prospective, controlled, single-blind, parallel-group clinical study. LEVEL OF EVIDENCE: Ib. SETTING: Military School of Cadets of the Colombian Army...
September 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28842109/treatment-of-medial-tibial-stress-syndrome-with-radial-soundwave-therapy-in-elite-athletes-current-evidence-report-on-two-cases-and%C3%A2-proposed-treatment-regimen
#3
Amol Saxena, Brian Fullem, Ludger Gerdesmeyer
Two case reports of high-level athletes with medial tibial stress syndrome (MTSS), 1 an Olympian with an actual stress fracture, are presented. Successful treatment included radial soundwave therapy, pneumatic leg braces, relative rest using an antigravity treadmill, and temporary foot orthoses. Radial soundwave therapy has a high level of evidence for treatment of MTSS. We also present recent evidence of the value of vitamin D assessment. Both patients had a successful outcome with minimal downtime. Finally, a suggested treatment regimen for MTSS is presented...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28717730/multicompartmental-trigeminal-schwannomas-dumbbell-tumors-revisited
#4
Abhishek Mahajan, Nilesh P Sable, Richa Vaish, Aliasgar Moiyadi, Supreeta Arya, Anil Keith D'Cruz
Multicompartmental trigeminal schwannomas (MTSs) are a rare and complex but treatable group of tumors. Herein, we describe the clinicoradiologic presentation of two patients with MTS. The two illustrated distinct case reports highlight the role of imaging and the outcome of two different types of MTS. The Discussion summarizes the literature to date, which will help the reader diagnose these tumors in a timely manner and manage them appropriately.
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28681148/effects-of-denosumab-treatment-on-bone-mineral-density-and-joint-destruction-in-patients-with-rheumatoid-arthritis
#5
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Naoko Koenuma, Mina Ishibashi, Shigeki Momohara
We aimed to investigate the efficacy of denosumab for rheumatoid arthritis (RA). This study enrolled 70 RA patients who received denosumab 60 mg subcutaneous injection at baseline and at 6 months. Bone mineral densities (BMD) of the lumbar spine, total hip, femoral neck, and hand were measured by dual energy X-ray absorptiometry. Changes in total modified Sharp score (mTSS), erosion (EN) score, and joint space narrowing score at baseline from 12 months before and at 12 months from baseline. The mean values of BMD of the lumbar spine, total hip, femoral neck, and hand significantly increased by 7...
July 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28674273/septal-membrane-localization-by-c-terminal-amphipathic-%C3%AE-helices-of-mind-in-bacillus-subtilis-mutant-cells-lacking-minj-or-diviva
#6
Kazuki Ishikawa, Satoshi Matsuoka, Hiroshi Hara, Kouji Matsumoto
The Min system, which inhibits assembly of the cytokinetic protein FtsZ, is largely responsible for positioning the division site in rod-shaped bacteria. It has been reported that MinJ, which bridges DivIVA and MinD, is targeted to the cell poles by an interaction with DivIVA, and that MinJ in turn recruits MinCD to the cell poles. MinC, however, is located primarily at active division sites at the mid-cell when expressed from its native promoter. Surprisingly, we found that B. subtilis MinD is located at nascent septal membranes and at an asymmetric site on lateral membranes between nascent septal membranes in filamentous cells lacking MinJ or DivIVA...
June 30, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28666080/a-phase-iii-study-evaluating-continuation-tapering-and-withdrawal-of-certolizumab-pegol-after-one-year-of-therapy-in-patients-with-early-rheumatoid-arthritis
#7
Michael E Weinblatt, Clifton O Bingham, Gerd-Rüdiger Burmester, Vivian P Bykerk, Daniel E Furst, Xavier Mariette, Désirée van der Heijde, Ronald van Vollenhoven, Brenda VanLunen, Cécile Ecoffet, Christopher Cioffi, Paul Emery
OBJECTIVE: In disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) who had achieved sustained low disease activity (a Disease Activity Score in 28 joints using the erythrocyte sedimentation rate of ≤3.2 at both week 40 and week 52) after 1 year of treatment with certolizumab pegol (CZP) at a standard dose (200 mg every 2 weeks plus optimized methotrexate [MTX]), we evaluated whether continuation of CZP treatment at a standard dose or at a reduced frequency (200 mg every 4 weeks plus MTX) was superior to stopping CZP (placebo plus MTX) in maintaining low disease activity for 1 additional year...
June 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28657583/epidermal-growth-factor-receptor-signaling-enhances-the-proinflammatory-effects-of-staphylococcus-aureus-gamma-toxin-on-the-mucosa
#8
Aaron N Gillman, Laura M Breshears, Charles K Kistler, Patrick M Finnegan, Victor J Torres, Patrick M Schlievert, Marnie L Peterson
Staphylococcus aureus (S. aureus) produces many different exotoxins including the gamma-toxins, HlgAB and HlgCB. Gamma-toxins form pores in both leukocyte and erythrocyte membranes, resulting in cell lysis. The genes encoding gamma-toxins are present in most strains of S. aureus, and are commonly expressed in clinical isolates recovered from menstrual Toxic Shock Syndrome (mTSS) patients. This study set out to investigate the cytotoxic and proinflammatory effects of gamma-toxins on vaginal epithelial surfaces...
June 28, 2017: Toxins
https://www.readbyqxmd.com/read/28613961/school-based-multi-tiered-systems-of-support-mtss-an-introduction-to-mtss-for-neuropsychologists
#9
Danielle Wexler
When completing pediatric neuropsychological evaluations, it is important for clinicians to incorporate data from children's school environments. Today, the educational data available to neuropsychologists have resulted from the utilization of multi-tiered systems of support (MTSS) within schools; however, practitioners may lack knowledge and/or training in this school-based approach to assessment and intervention. Better understanding of MTSS may aid pediatric neuropsychologists in their interpretation and use of educational data commonly provided by schools...
June 14, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28581815/biomechanical-factors-associated-with-achilles-tendinopathy-and-medial-tibial-stress-syndrome-in-runners
#10
James Becker, Stanley James, Robert Wayner, Louis Osternig, Li-Shan Chou
BACKGROUND: There is disagreement in the literature regarding whether the excessive excursion or velocity of rearfoot eversion is related to the development of 2 common running injuries: Achilles tendinopathy (AT) and medial tibial stress syndrome (MTSS). An alternative hypothesis suggests that the duration of rearfoot eversion may be an important factor. However, the duration of eversion has received relatively little attention in the biomechanics literature. HYPOTHESIS: Runners with AT or MTSS will demonstrate a longer duration of eversion but not greater excursion or velocity of eversion compared with healthy controls...
September 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28505163/anti-citrullinated-peptide-antibodies-are-the-strongest-predictor-of-clinically-relevant-radiographic-progression-in-rheumatoid-arthritis-patients-achieving-remission-or-low-disease-activity-a-post-hoc-analysis-of-a-nationwide-cohort-in-japan
#11
Tomohiro Koga, Akitomo Okada, Takaaki Fukuda, Toshihiko Hidaka, Tomonori Ishii, Yukitaka Ueki, Takao Kodera, Munetoshi Nakashima, Yuichi Takahashi, Seiyo Honda, Yoshiro Horai, Ryu Watanabe, Hiroshi Okuno, Toshiyuki Aramaki, Tomomasa Izumiyama, Osamu Takai, Taiichiro Miyashita, Shuntaro Sato, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Hideki Nakamura, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVES: To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) achieving remission or low disease activity (LDA) in clinical practice. METHODS: Using data from a nationwide, multicenter, prospective study in Japan, we evaluated 198 biological disease-modifying antirheumatic drug (bDMARD)-naïve RA patients who were in remission or had LDA at study entry after being treated with conventional synthetic DMARDs (csDMARDs)...
2017: PloS One
https://www.readbyqxmd.com/read/28472427/construct-and-predictive-validity-of-three-measures-of-intention-to-quit-smoking-findings-from-the-international-tobacco-control-itc-netherlands-survey
#12
Karin Hummel, Math J J M Candel, Gera E Nagelhout, Jamie Brown, Bas van den Putte, Daniel Kotz, Marc C Willemsen, Geoffrey T Fong, Robert West, Hein de Vries
Introduction: The aim of the study was to compare the construct validity and the predictive validity of three instruments to measure intention to quit smoking: a Stages of Change measure, the Motivation To Stop Scale (MTSS) and a Likert scale. We used the Theory of Planned Behaviour as theoretical framework. Methods: We used data from the International Tobacco Control (ITC) Netherlands Survey. We included smokers who participated in three consecutive survey waves (n=980)...
May 3, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28413452/ankle-and-toe-muscle-strength-characteristics-in-runners-with-a-history-of-medial-tibial-stress-syndrome
#13
Junya Saeki, Masatoshi Nakamura, Sayaka Nakao, Kosuke Fujita, Ko Yanase, Katsuyuki Morishita, Noriaki Ichihashi
BACKGROUND: A high proportion of flexor digitorum longus attachment is found at the posteromedial border of the tibia, which is the most common location of medial tibial stress syndrome (MTSS). Therefore, plantar flexion strength of the lesser toes could be related to MTSS; however, the relationship between MTSS and muscle strength of the hallux and lesser toes is not yet evaluated due to the lack of quantitative methods. This study investigated the muscle strength characteristics in runners with a history of MTSS by using a newly developed device to measure the muscle strength of the hallux, lesser toes, and ankle...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28404644/preprotein-mature-domains-contain-translocase-targeting-signals-that-are-essential-for-secretion
#14
Katerina E Chatzi, Marios Frantzeskos Sardis, Alexandra Tsirigotaki, Marina Koukaki, Nikolina Šoštarić, Albert Konijnenberg, Frank Sobott, Charalampos G Kalodimos, Spyridoula Karamanou, Anastassios Economou
Secretory proteins are only temporary cytoplasmic residents. They are typically synthesized as preproteins, carrying signal peptides N-terminally fused to their mature domains. In bacteria secretion largely occurs posttranslationally through the membrane-embedded SecA-SecYEG translocase. Upon crossing the plasma membrane, signal peptides are cleaved off and mature domains reach their destinations and fold. Targeting to the translocase is mediated by signal peptides. The role of mature domains in targeting and secretion is unclear...
May 1, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28207961/muscle-stiffness-of-posterior-lower-leg-in-runners-with-a-history-of-medial-tibial-stress-syndrome
#15
J Saeki, M Nakamura, S Nakao, K Fujita, K Yanase, N Ichihashi
Previous history of medial tibial stress syndrome (MTSS) is a risk factor for MTSS relapse, which suggests that there might be some physical factors that are related to MTSS development in runners with a history of MTSS. The relationship between MTSS and muscle stiffness can be assessed in a cross-sectional study that measures muscle stiffness in subjects with a history of MTSS, who do not have pain at the time of measurement, and in those without a history of MTSS. The purpose of this study was to compare the shear elastic modulus, which is an index of muscle stiffness, of all posterior lower leg muscles of subjects with a history of MTSS and those with no history and investigate which muscles could be related to MTSS...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28199814/baricitinib-versus-placebo-or-adalimumab-in-rheumatoid-arthritis
#16
RANDOMIZED CONTROLLED TRIAL
Peter C Taylor, Edward C Keystone, Désirée van der Heijde, Michael E Weinblatt, Liliana Del Carmen Morales, Jaime Reyes Gonzaga, Sergey Yakushin, Taeko Ishii, Kahaku Emoto, Scott Beattie, Vipin Arora, Carol Gaich, Terence Rooney, Douglas Schlichting, William L Macias, Stephanie de Bono, Yoshiya Tanaka
BACKGROUND: Baricitinib is an oral, reversible inhibitor of the Janus kinases JAK1 and JAK2 that may have therapeutic value in patients with rheumatoid arthritis. METHODS: We conducted a 52-week, phase 3, double-blind, placebo- and active-controlled trial in which 1307 patients with active rheumatoid arthritis who were receiving background therapy with methotrexate were randomly assigned to one of three regimens in a 3:3:2 ratio: placebo (switched to baricitinib after 24 weeks), 4 mg of baricitinib once daily, or 40 mg of adalimumab (an anti-tumor necrosis factor α monoclonal antibody) every other week...
February 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28179260/medial-tibial-stress-syndrome-can-be-diagnosed-reliably-using-history-and-physical-examination
#17
M Winters, E W P Bakker, M H Moen, C C Barten, R Teeuwen, A Weir
BACKGROUND: The majority of sporting injuries are clinically diagnosed using history and physical examination as the cornerstone. There are no studies supporting the reliability of making a clinical diagnosis of medial tibial stress syndrome (MTSS). AIM: Our aim was to assess if MTSS can be diagnosed reliably, using history and physical examination. We also investigated if clinicians were able to reliably identify concurrent lower leg injuries. METHODS: A clinical reliability study was performed at multiple sports medicine sites in The Netherlands...
February 8, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28177479/external-validation-of-the-motivation-to-stop-scale-mtss-findings-from-the-international-tobacco-control-itc-netherlands-survey
#18
Karin Hummel, Jamie Brown, Marc C Willemsen, Robert West, Daniel Kotz
No abstract text is available yet for this article.
February 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28168776/treatment-outcomes-and-prognostic-factors-of-feline-splenic-mast-cell-tumors-a-multi-institutional-retrospective-study-of-64-cases
#19
B J Evans, D O'Brien, S D Allstadt, T P Gregor, K U Sorenmo
BACKGROUND: Mast cell tumors (MCT) are common splenic tumors in cats, but there is limited information on treatment outcomes of cats with this disease. MATERIALS AND METHODS: This retrospective study evaluated treatment outcomes in 64 cats with splenic MCT. Cats were categorized into the following treatment groups: splenectomy (A, n = 20); splenectomy with chemotherapy (B, n = 20); chemotherapy alone (C, n = 15); or supportive care (D, n = 9). RESULTS: Median tumor specific survival (MTSS) was: 856, 853, 244, 365 days for groups A, B, C, and D, respectively...
February 7, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27922222/delving-into-the-details-implementing-multitiered-k-3-reading-supports-in-high-priority-schools
#20
Michael D Coyne, Ashley Oldham, Kaitlin Leonard, Darci Burns, Nicholas Gage
Although there is widespread agreement about the practices associated with multitiered systems of support (MTSS) frameworks in beginning reading, we often underestimate the systems and infrastructure that schools need to implement and sustain these practices. The real work of developing these systems often happens in the detailed-oriented and often messy world of schedules, routines, meetings, and materials. The purpose of this article is to describe a K-3 reading initiative where school teams serving high percentages of students at risk for reading difficulties "delved into the details" to work to overcome the complexities inherent in implementing multitiered reading supports in high priority schools...
December 2016: New Directions for Child and Adolescent Development
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