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https://www.readbyqxmd.com/read/29318552/beyond-the-proteolytic-activity-examining-the-functional-relevance-of-the%C3%A2-ancillary-domains-using-tri-dimensional-3d-spheroid-invasion-assay
#1
Erico Tosoni Costa, Anamaria Aranha Camargo
In this chapter, we describe a straightforward protocol to generate multicellular tumor spheroids (MTSs) and evaluate the role of specific genes in regulating cell invasiveness in real-time and tridimensional (3D) matrices. This approach provides advantages over other conventional invasion assays by offering intimate cell-cell and cell-ECM contacts and by mimicking the pathophysiological characteristics observed in tumor microenvironments (e.g., microregional gradients in glucose and O2 concentrations and metabolic and proliferative tumor heterogeneity)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29312834/joint-damage-is-amplified-in-rheumatoid-arthritis-patients-with-positive-thyroid-autoantibodies
#2
Yu-Lan Chen, Jian-Zi Lin, Ying-Qian Mo, Jin-Jian Liang, Qian-Hua Li, Cheng-Jing Zhou, Xiu-Ning Wei, Jian-Da Ma, Ze-Hong Yang, Dong-Hui Zheng, Lie Dai
Background: Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated with rheumatoid arthritis (RA) because AITD and RA both involve autoimmunity. However, few data are available on the incidence of TAbs in Chinese RA patients, and studies on the association between TAbs and joint damage as well as synovitis in RA patients remain sparse...
2018: PeerJ
https://www.readbyqxmd.com/read/29307020/gross-total-resection-of-pituitary-adenomas-after-endoscopic-vs-microscopic-transsphenoidal-surgery-a-meta-analysis
#3
REVIEW
Reem D Almutairi, Ivo S Muskens, David J Cote, Mark D Dijkman, Vasileios K Kavouridis, Erin Crocker, Kholoud Ghazawi, Marike L D Broekman, Timothy R Smith, Rania A Mekary, Hasan A Zaidi
BACKGROUND: Microscopic transsphenoidal surgery (mTSS) is a well-established method to address adenomas of the pituitary gland. Endoscopic transsphenoidal surgery (eTSS) has become a viable alternative, however. Advocates suggest that the greater illumination, panoramic visualization, and angled endoscopic views afforded by eTSS may allow for higher rates of gross total tumor resection (GTR). The aim of this meta-analysis was to determine the rate of GTR using mTSS and eTSS. METHODS: A meta-analysis of the literature was conducted using PubMed, EMBASE, and Cochrane databases through July 2017 in accordance with PRISMA guidelines...
January 6, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29238405/the-effect-of-a-running-task-on-muscle-shear-elastic-modulus-of-posterior-lower-leg
#4
Shuhei Ohya, Masatoshi Nakamura, Takafumi Aoki, Daichi Suzuki, Takanori Kikumoto, Emi Nakamura, Wataru Ito, Ryo Hirabayashi, Tomoya Takabayashi, Mutsuaki Edama
Background: Medial tibial stress syndrome (MTSS) is one of the most common causes of exercise-related leg pain in runners. Because stopping training due to pain from MTSS could decrease the athlete's competitiveness, it is necessary to construct MTSS prevention and treatment programs. However, the effect of running, which is believed to cause MTSS, on shear elastic modulus of the posterior lower leg is unclear. Therefore, the purpose of this study was to investigate the effect of 30 min of running on shear elastic modulus of the posterior lower leg in healthy subjects...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29233157/medical-student-intervention-to-promote-effective-nicotine-dependence-and-tobacco-healthcare-mind-the-gap-single-centre-feasibility-randomised-trial-results
#5
Anusha Kumar, Kenneth D Ward, Lisa Mellon, Miriam Gunning, Sinead Stynes, Anne Hickey, Ronán Conroy, Shane MacSweeney, David Horan, Liam Cormican, Seamus Sreenan, Frank Doyle
BACKGROUND: Although brief cessation advice from healthcare professionals increases quit rates, smokers typically do not get this advice during hospitalisation, possibly due to resource issues, lack of training and professionals' own attitudes to providing such counselling. Medical students are a potentially untapped resource who could deliver cessation counselling, while upskilling themselves and changing their own attitudes to delivering such advice in the future; however, no studies have investigated this...
December 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29218652/metastasis-suppressor-1-mtss1-expression-is-associated-with-reduced-in-vivo-metastasis-and-enhanced-patient-survival-in-lung-adenocarcinoma
#6
Matthew D Taylor, Oana Bollt, Soumya C Iyer, Gavin P Robertson
Metastasis suppressor 1 (MTSS1) has been shown to be a metastasis suppressor in a number of cancers. However, its role in lung adenocarcinoma is largely unknown. To evaluate the significance of MTSS1 expression on lung adenocarcinoma metastatic properties, the gain or loss of MTSS1 in in vivo and in vitro experiments were employed. Using an in vivo orthotopic mouse xenograft model mimicking human disease progression, stable overexpression of MTSS1 in lung adenocarcinoma cells resulted in a significant decrease in metastatic burden...
December 7, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29145309/short-term-effects-of-sports-taping-on-navicular-height-navicular-drop-and-peak-plantar-pressure-in-healthy-elite-athletes-a-within-subject-comparison
#7
RANDOMIZED CONTROLLED TRIAL
Taegyu Kim, Jong-Chul Park
Medial tibial stress syndrome (MTSS) is one of the most common exercise-induced leg pain. The navicular drop (ND) was identified as a risk factor for MTSS. This study aimed to evaluate the short-term effects of sports taping applied to the supporting lower leg during sitting, standing, walking, and jogging to restrict the ND in healthy elite athletes.Twenty-four healthy elite athletes without a history of exercise-induced pain or injuries in the lower limbs participated in this study (median age: 21.00 years; 1st--3rd quartiles; 19...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29138986/secukinumab-in-active-rheumatoid-arthritis-after-anti-tnf%C3%AE-therapy-a-randomized-double-blind-placebo-controlled-phase-3-study
#8
Hasan Tahir, Atul Deodhar, Mark Genovese, Tsutomu Takeuchi, Jacob Aelion, Filip Van den Bosch, Sibylle Haemmerle, Hanno B Richards
INTRODUCTION: 'REASSURE' (NCT01377012), a phase 3 study, evaluated the efficacy and safety of secukinumab in patients with active rheumatoid arthritis (RA) who had an inadequate response to, or intolerance of, tumor necrosis factor inhibitors (TNF-inhibitors). METHODS: A total of 637 patients were randomized (1:1:1) to receive intravenous secukinumab 10 mg/kg (baseline, weeks 2 and 4) followed by subcutaneous secukinumab 150 mg or 75 mg every 4 weeks (starting from week 8) or placebo at the same dosing schedule...
December 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29122474/predicting-individual-risk-for-medial-tibial-stress-syndrome-in-navy-recruits
#9
Cameron Garnock, Jeremy Witchalls, Phil Newman
OBJECTIVES: Quantifying individual risk for medial tibial stress syndrome (MTSS) is valuable due to the high prevalence, substantial financial and service costs, and lengthy recovery time of the condition. Identification of those at risk is a key first step in prevention of the condition. This study aimed to test a suite of best evidence risk factors in a cohort of Navy recruits and to develop a predictive model for individuals at risk of MTSS. DESIGN: Prospective cohort study of Navy recruits undergoing initial training METHODS: A prospective cohort design, this study screened recruits by assessing gender, MTSS history, years of running experience, orthotic use, BMI, navicular drop, ankle plantarflexion and hip external rotation at the beginning of basic training...
October 23, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29080511/influence-of-outdoor-running-fatigue-and-medial-tibial-stress-syndrome-on-accelerometer-based-loading-and-stability
#10
Kurt H Schütte, Stefan Seerden, Rachel Venter, Benedicte Vanwanseele
Medial tibial stress syndrome (MTSS) is a common overuse running injury with pathomechanics likely to be exaggerated by fatigue. Wearable accelerometry provides a novel alternative to assess biomechanical parameters continuously while running in more ecologically valid settings. The purpose of this study was to determine the influence of outdoor running fatigue and MTSS on both dynamic loading and dynamic stability derived from trunk and tibial accelerometery. Runners with (n=14) and without (n=16) history of MTSS performed an outdoor fatigue run of 3200m...
January 2018: Gait & Posture
https://www.readbyqxmd.com/read/28968793/52-week-results-of-the-phase-3-randomized-study-comparing-sb4-with-reference-etanercept-in-patients-with-active-rheumatoid-arthritis
#11
RANDOMIZED CONTROLLED TRIAL
Paul Emery, Jirí Vencovský, Anna Sylwestrzak, Piotr Leszczynski, Wieslawa Porawska, Asta Baranauskaite, Vira Tseluyko, Vyacheslav M Zhdan, Barbara Stasiuk, Roma Milasiene, Aaron Alejandro Barrera Rodriguez, Soo Yeon Cheong, Jeehoon Ghil
Objective: To compare the 52-week efficacy and safety of SB4 [an etanercept biosimilar] with reference etanercept (ETN) in patients with active RA. Methods: In a phase 3, randomized, double-blind, multicentre study, patients with moderate to severe RA despite MTX treatment were randomized to receive 50 mg/week of s.c. SB4 or ETN up to week 52. Efficacy assessments included ACR response rates, 28-joint DAS, Simplified and Clinical Disease Activity Indices and changes in the modified total Sharp score (mTSS)...
December 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28954794/the-effectiveness-of-extracorporeal-shockwave-therapy-in-common-lower-limb-conditions-a-systematic-review-including-quantification-of-patient-rated-pain-reduction
#12
REVIEW
Vasileios Korakakis, Rodney Whiteley, Alexander Tzavara, Nikolaos Malliaropoulos
OBJECTIVE: To evaluate extracorporeal shockwave therapy (ESWT) in treating Achilles tendinopathy (AT), greater trochanteric pain syndrome (GTPS), medial tibial stress syndrome (MTSS), patellar tendinopathy (PT) and proximal hamstring tendinopathy (PHT). DESIGN: Systematic review. ELIGIBILITY CRITERIA: Randomised and non-randomised studies assessing ESWT in patients with AT, GTPS, MTSS, PT and PHT were included. Risk of bias and quality of studies were evaluated...
September 27, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28890727/popliteal-artery-entrapment-or-chronic-exertional-compartment-syndrome
#13
Christopher Gaunder, Brandon McKinney, Jessica Rivera
Diagnosis of lower limb pain in an athlete can be a challenging task due to the variety of potential etiologies and ambiguity of presenting symptoms. Five of the most commonly encountered causes of limb pain in athletes are chronic exertional compartment syndrome (CECS), medial tibial stress syndrome (MTSS), tibial stress fractures, soleal sling syndrome, and popliteal artery entrapment syndrome (PAES). Of these, the least frequent but potentially most serious of the pathologies is PAES. With an incidence of less than 1% seen in living subject studies, the condition is rare...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28882773/shockwave-treatment-for-medial-tibial-stress-syndrome-in-military-cadets-a-single-blind-randomized-controlled-trial
#14
Santiago Gomez Garcia, Silvia Ramon Rona, Martha Claudia Gomez Tinoco, Mikhail Benet Rodriguez, Diego Mauricio Chaustre Ruiz, Francia Piedad Cardenas Letrado, África Lopez-Illescas Ruiz, Juan Maria Alarcon Garcia
Medial tibial stress syndrome (MTSS) is a common injury in athletes and soldiers. Several studies have demonstrated the effectiveness of extracorporeal shockwave treatment (ESWT) in athletes with MTSS. OBJECTIVE: To assess whether one session of focused ESWT is effective in the treatment of military cadets with MTSS. DESIGN: A randomized, prospective, controlled, single-blind, parallel-group clinical study. LEVEL OF EVIDENCE: Ib. SETTING: Military School of Cadets of the Colombian Army...
October 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28842109/treatment-of-medial-tibial-stress-syndrome-with-radial-soundwave-therapy-in-elite-athletes-current-evidence-report-on-two-cases-and%C3%A2-proposed-treatment-regimen
#15
Amol Saxena, Brian Fullem, Ludger Gerdesmeyer
Two case reports of high-level athletes with medial tibial stress syndrome (MTSS), 1 an Olympian with an actual stress fracture, are presented. Successful treatment included radial soundwave therapy, pneumatic leg braces, relative rest using an antigravity treadmill, and temporary foot orthoses. Radial soundwave therapy has a high level of evidence for treatment of MTSS. We also present recent evidence of the value of vitamin D assessment. Both patients had a successful outcome with minimal downtime. Finally, a suggested treatment regimen for MTSS is presented...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28717730/multicompartmental-trigeminal-schwannomas-dumbbell-tumors-revisited
#16
Abhishek Mahajan, Nilesh P Sable, Richa Vaish, Aliasgar Moiyadi, Supreeta Arya, Anil Keith D'Cruz
Multicompartmental trigeminal schwannomas (MTSs) are a rare and complex but treatable group of tumors. Herein, we describe the clinicoradiologic presentation of two patients with MTS. The two illustrated distinct case reports highlight the role of imaging and the outcome of two different types of MTS. The Discussion summarizes the literature to date, which will help the reader diagnose these tumors in a timely manner and manage them appropriately.
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28681148/effects-of-denosumab-treatment-on-bone-mineral-density-and-joint-destruction-in-patients-with-rheumatoid-arthritis
#17
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Naoko Koenuma, Mina Ishibashi, Shigeki Momohara
We aimed to investigate the efficacy of denosumab for rheumatoid arthritis (RA). This study enrolled 70 RA patients who received denosumab 60 mg subcutaneous injection at baseline and at 6 months. Bone mineral densities (BMD) of the lumbar spine, total hip, femoral neck, and hand were measured by dual energy X-ray absorptiometry. Changes in total modified Sharp score (mTSS), erosion (EN) score, and joint space narrowing score at baseline from 12 months before and at 12 months from baseline. The mean values of BMD of the lumbar spine, total hip, femoral neck, and hand significantly increased by 7...
July 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28674273/septal-membrane-localization-by-c-terminal-amphipathic-%C3%AE-helices-of-mind-in-bacillus-subtilis-mutant-cells-lacking-minj-or-diviva
#18
Kazuki Ishikawa, Satoshi Matsuoka, Hiroshi Hara, Kouji Matsumoto
The Min system, which inhibits assembly of the cytokinetic protein FtsZ, is largely responsible for positioning the division site in rod-shaped bacteria. It has been reported that MinJ, which bridges DivIVA and MinD, is targeted to the cell poles by an interaction with DivIVA, and that MinJ in turn recruits MinCD to the cell poles. MinC, however, is located primarily at active division sites at mid-cell when expressed from its native promoter. Surprisingly, we found that Bacillus subtilis MinD is located at nascent septal membranes and at an asymmetric site on lateral membranes between nascent septal membranes in filamentous cells lacking MinJ or DivIVA...
October 18, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28666080/a-phase-iii-study-evaluating-continuation-tapering-and-withdrawal-of-certolizumab-pegol-after-one-year-of-therapy-in-patients-with-early-rheumatoid-arthritis
#19
RANDOMIZED CONTROLLED TRIAL
Michael E Weinblatt, Clifton O Bingham, Gerd-Rüdiger Burmester, Vivian P Bykerk, Daniel E Furst, Xavier Mariette, Désirée van der Heijde, Ronald van Vollenhoven, Brenda VanLunen, Cécile Ecoffet, Christopher Cioffi, Paul Emery
OBJECTIVE: In disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) who had achieved sustained low disease activity (a Disease Activity Score in 28 joints using the erythrocyte sedimentation rate of ≤3.2 at both week 40 and week 52) after 1 year of treatment with certolizumab pegol (CZP) at a standard dose (200 mg every 2 weeks plus optimized methotrexate [MTX]), we evaluated whether continuation of CZP treatment at a standard dose or at a reduced frequency (200 mg every 4 weeks plus MTX) was superior to stopping CZP (placebo plus MTX) in maintaining low disease activity for 1 additional year...
October 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28657583/epidermal-growth-factor-receptor-signaling-enhances-the-proinflammatory-effects-of-staphylococcus-aureus-gamma-toxin-on-the-mucosa
#20
Aaron N Gillman, Laura M Breshears, Charles K Kistler, Patrick M Finnegan, Victor J Torres, Patrick M Schlievert, Marnie L Peterson
Staphylococcus aureus (S. aureus) produces many different exotoxins including the gamma-toxins, HlgAB and HlgCB. Gamma-toxins form pores in both leukocyte and erythrocyte membranes, resulting in cell lysis. The genes encoding gamma-toxins are present in most strains of S. aureus, and are commonly expressed in clinical isolates recovered from menstrual Toxic Shock Syndrome (mTSS) patients. This study set out to investigate the cytotoxic and proinflammatory effects of gamma-toxins on vaginal epithelial surfaces...
June 28, 2017: Toxins
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