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https://www.readbyqxmd.com/read/28207961/muscle-stiffness-of-posterior-lower-leg-in-runners-with-a-history-of-medial-tibial-stress-syndrome
#1
Junya Saeki, Masatoshi Nakamura, Sayaka Nakao, Kosuke Fujita, Ko Yanase, Noriaki Ichihashi
Previous history of medial tibial stress syndrome (MTSS) is a risk factor for MTSS relapse, which suggests that there might be some physical factors that are related to MTSS development in runners with a history of MTSS. The relationship between MTSS and muscle stiffness can be assessed in a cross-sectional study that measures muscle stiffness in subjects with a history of MTSS, who do not have pain at the time of measurement, and in those without a history of MTSS. The purpose of this study was to compare the shear elastic modulus, which is an index of muscle stiffness, of all posterior lower leg muscles of subjects with a history of MTSS and those with no history and investigate which muscles could be related to MTSS...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28199814/baricitinib-versus-placebo-or-adalimumab-in-rheumatoid-arthritis
#2
RANDOMIZED CONTROLLED TRIAL
Peter C Taylor, Edward C Keystone, Désirée van der Heijde, Michael E Weinblatt, Liliana Del Carmen Morales, Jaime Reyes Gonzaga, Sergey Yakushin, Taeko Ishii, Kahaku Emoto, Scott Beattie, Vipin Arora, Carol Gaich, Terence Rooney, Douglas Schlichting, William L Macias, Stephanie de Bono, Yoshiya Tanaka
Background Baricitinib is an oral, reversible inhibitor of the Janus kinases JAK1 and JAK2 that may have therapeutic value in patients with rheumatoid arthritis. Methods We conducted a 52-week, phase 3, double-blind, placebo- and active-controlled trial in which 1307 patients with active rheumatoid arthritis who were receiving background therapy with methotrexate were randomly assigned to one of three regimens in a 3:3:2 ratio: placebo (switched to baricitinib after 24 weeks), 4 mg of baricitinib once daily, or 40 mg of adalimumab (an anti-tumor necrosis factor α monoclonal antibody) every other week...
February 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28179260/medial-tibial-stress-syndrome-can-be-diagnosed-reliably-using-history-and-physical-examination
#3
M Winters, E W P Bakker, M H Moen, C C Barten, R Teeuwen, A Weir
BACKGROUND: The majority of sporting injuries are clinically diagnosed using history and physical examination as the cornerstone. There are no studies supporting the reliability of making a clinical diagnosis of medial tibial stress syndrome (MTSS). AIM: Our aim was to assess if MTSS can be diagnosed reliably, using history and physical examination. We also investigated if clinicians were able to reliably identify concurrent lower leg injuries. METHODS: A clinical reliability study was performed at multiple sports medicine sites in The Netherlands...
February 8, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28177479/external-validation-of-the-motivation-to-stop-scale-mtss-findings-from-the-international-tobacco-control-itc-netherlands-survey
#4
Karin Hummel, Jamie Brown, Marc C Willemsen, Robert West, Daniel Kotz
No abstract text is available yet for this article.
February 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28168776/treatment-outcomes-and-prognostic-factors-of-feline-splenic-mast-cell-tumors-a-multi-institutional-retrospective-study-of-64-cases
#5
B J Evans, D O'Brien, S D Allstadt, T P Gregor, K U Sorenmo
BACKGROUND: Mast cell tumors (MCT) are common splenic tumors in cats, but there is limited information on treatment outcomes of cats with this disease. MATERIALS AND METHODS: This retrospective study evaluated treatment outcomes in 64 cats with splenic MCT. Cats were categorized into the following treatment groups: splenectomy (A, n = 20); splenectomy with chemotherapy (B, n = 20); chemotherapy alone (C, n = 15); or supportive care (D, n = 9). RESULTS: Median tumor specific survival (MTSS) was: 856, 853, 244, 365 days for groups A, B, C, and D, respectively...
February 7, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27922222/delving-into-the-details-implementing-multitiered-k-3-reading-supports-in-high-priority-schools
#6
Michael D Coyne, Ashley Oldham, Kaitlin Leonard, Darci Burns, Nicholas Gage
Although there is widespread agreement about the practices associated with multitiered systems of support (MTSS) frameworks in beginning reading, we often underestimate the systems and infrastructure that schools need to implement and sustain these practices. The real work of developing these systems often happens in the detailed-oriented and often messy world of schedules, routines, meetings, and materials. The purpose of this article is to describe a K-3 reading initiative where school teams serving high percentages of students at risk for reading difficulties "delved into the details" to work to overcome the complexities inherent in implementing multitiered reading supports in high priority schools...
December 2016: New Directions for Child and Adolescent Development
https://www.readbyqxmd.com/read/27919205/achieving-simplified-disease-activity-index-remission-in-patients-with-active-rheumatoid-arthritis-is-associated-with-subsequent-good-functional-and-structural-outcomes-in-a-real-world-clinical-setting-under-a-treat-to-target-strategy
#7
Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). METHODS: In this multicenter, prospective cohort study, T2T was implemented in rheumatoid arthritis (RA) patients with moderate-to-high disease activity. SDAI or clinical disease activity index (CDAI) was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity (LDA)...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846756/simplified-disease-activity-index-remission-at-month-6-is-an-independent-predictor-of-functional-and-structural-remissions-at-month-12-during-abatacept-treatment-in-patients-with-rheumatoid-arthritis-a-multi-center-prospective-cohort-study-in-japan
#8
Hayato Yamazaki, Fumio Hirano, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Mari Kihara, Waka Yokoyama, Takahiko Sugihara, Kenji Nagasaka, Hiroyuki Hagiyama, Yoshinori Nonomura, Ryoko Sakai, Michi Tanaka, Ryuji Koike, Toshihiro Nanki, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To evaluate association of clinical remission at month 6 with functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis (RA). METHODS: This 12-month prospective, multicenter cohort study enrolled 168 patients with RA who started abatacept. Outcomes were assessed using composite measures, quality of life indices, and the van der Heijde-modified total Sharp score (mTSS). The logistic regression analysis was applied to identify factors associated with outcomes and their odds ratios (OR) with 95% confidence interval (95% CI)...
December 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27835043/risk-factors-for-medial-tibial-stress-syndrome-in-active-individuals-an-evidence-based-review
#9
REVIEW
Zachary K Winkelmann, Dustin Anderson, Kenneth E Games, Lindsey E Eberman
Reference/Citation: Hamstra-Wright KL, Bliven KC, Bay C. Risk factors for medial tibial stress syndrome in physically active individuals such as runners and military personnel: a systematic review and meta-analysis. Br J Sports Med. 2015;49(6):362-369. CLINICAL QUESTION: What factors put physically active individuals at risk to develop medial tibial stress syndrome (MTSS)? DATA SOURCES: The authors performed a literature search of CINAHL, the Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE from each database's inception to July 2013...
December 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27830955/relationship-between-roentgenographic-joint-destruction-in-the-hands-and-functional-disorders-among-patients-with-rheumatoid-arthritis
#10
Tetsuro Yasui, Hiroyuki Oka, Yasunori Omata, Yuho Kadono, Sakae Tanaka
OBJECTIVES: Although a relationship between joint destruction and functional disorders seems apparent in patients with rheumatoid arthritis (RA), it has not been well proven in the literature. The aims of this study were to clarify the relationship between roentgenographic joint destruction in the hands and functional disorders in patients with RA, and to explore the appropriate assessment measures for functional disorders. METHODS: Cross-sectional data of the Genant-modified Total Sharp Score (Genant-mTSS), Health Assessment Questionnaire-Disability Index (HAQ-DI), Disabilities of the Arm, Shoulder, and Hand (DASH), and Michigan Hand Outcomes Questionnaire (MHQ) were collected from 50 consecutive RA patients and analyzed...
November 10, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27779848/single-molecule-force-measurements-in-living-cells-reveal-a-minimally-tensioned-integrin-state
#11
Alice C Chang, Armen H Mekhdjian, Masatoshi Morimatsu, Aleksandra Kirillovna Denisin, Beth L Pruitt, Alexander R Dunn
Integrins mediate cell adhesion to the extracellular matrix and enable the construction of complex, multicellular organisms, yet fundamental aspects of integrin-based adhesion remain poorly understood. Notably, the magnitude of the mechanical load experienced by individual integrins within living cells is unclear, due principally to limitations inherent to existing techniques. Here we use Förster resonance energy transfer-based molecular tension sensors to directly measure the distribution of loads experienced by individual integrins in living cells...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27771440/heterologous-mitochondrial-targeting-sequences-can-deliver-functional-proteins-into-mitochondria
#12
Dana Marcus, Michal Lichtenstein, Natali Cohen, Rita Hadad, Tal Erlich-Hadad, Hagar Greif, Haya Lorberboum-Galski
Mitochondrial Targeting Sequences (MTSs) are responsible for trafficking nuclear-encoded proteins into mitochondria. Once entering the mitochondria, the MTS is recognized and cleaved off. Some MTSs are long and undergo two-step processing, as in the case of the human frataxin (FXN) protein (80aa), implicated in Friedreich's ataxia (FA). Therefore, we chose the FXN protein to examine whether nuclear-encoded mitochondrial proteins can efficiently be targeted via a heterologous MTS (hMTS) and deliver a functional protein into mitochondria...
December 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27729482/medial-tibial-stress-syndrome-in-active-individuals-a-systematic-review-and-meta-analysis-of-risk-factors
#13
Mark F Reinking, Tricia M Austin, Randy R Richter, Mary M Krieger
CONTEXT: Medial tibial stress syndrome (MTSS) is a common condition in active individuals and presents as diffuse pain along the posteromedial border of the tibia. OBJECTIVE: To use cross-sectional, case-control, and cohort studies to identify significant MTSS risk factors. DATA SOURCES: Bibliographic databases (PubMed, Scopus, CINAHL, SPORTDiscus, EMBASE, EBM Reviews, PEDRo), grey literature, electronic search of full text of journals, manual review of reference lists, and automatically executed PubMed MTSS searches were utilized...
October 11, 2016: Sports Health
https://www.readbyqxmd.com/read/27663201/is-radiographic-progression-in-modern-rheumatoid-arthritis-trials-still-a-robust-outcome-experience-from-tofacitinib-clinical-trials
#14
Robert B M Landewé, Carol A Connell, John D Bradley, Bethanie Wilkinson, David Gruben, Sander Strengholt, Désirée van der Heijde
BACKGROUND: The detection of statistically significant reductions in radiographic progression during clinical studies in patients with rheumatoid arthritis (RA) has become increasingly difficult over the past decade due to early-escape study designs and declining rates of progression in control-group patients. We investigated the impact of extremes of radiographic data (outliers) and baseline prognostic factors on detection of treatment effects, to provide guidance on future analysis of joint structural data in RA clinical trials...
September 23, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27640922/shockwave-treatment-for-medial-tibial-stress-syndrome-a-randomized-double-blind-sham-controlled-pilot-trial
#15
Phil Newman, Gordon Waddington, Roger Adams
OBJECTIVES: Up to 35% of runners develop medial tibial stress syndrome (MTSS) which often results in lengthy disruption to training and sometimes affects daily activities. There is currently no high quality evidence to support any particular intervention for MTSS. This study aims to investigate the effect of shockwave therapy for MTSS. DESIGN: A randomized, sham-controlled, pilot trial in a university-based health clinic including 28 active adults with MTSS. METHODS: Intervention included standard dose shockwave therapy for the experimental group versus sham dose for the control group, delivered during Week 1-3, 5 and 9...
March 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27632881/atrophy-and-depigmentation-after-pretibial-corticosteroid-injection-for-medial-tibial-stress-syndrome-two-case-reports
#16
Miette F Loopik, Marinus Winters, Maarten H Moen
INTRODUCTION: No reports have been published on the results of corticosteroid injections for medial tibial stress syndrome (MTSS). CASE PRESENTATION: The authors present 2 cases of women with MTSS who showed atrophy and depigmentation of the skin after pretibial corticosteroid injections. Case 1 is an 18-y-old woman presenting with pain in her lower leg for 12 mo. No improvement was noticed after conservative treatment, so she received local injections with corticosteroids...
December 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27612357/short-term-results-of-a-rehabilitation-program-for-service-members-with-lower-leg-pain-and-the-evaluation-of-patient-characteristics
#17
Mariëtte Z Meulekamp, Wieteke Sauter, Marieke Buitenhuis, Agali Mert, Peter van der Wurff
INTRODUCTION: Lower leg pain (LLP), including medial tibial stress syndrome (MTSS) and chronic exertional compartment syndrome (CECS), remains a major problem for the military. OBJECTIVE: Evaluation of patient characteristics and short-term results of the rehabilitation program for service members used in the Military Rehabilitation Centre Aardenburg. METHODS: This retrospective study includes 161 service members of the Netherlands Armed Forces...
September 2016: Military Medicine
https://www.readbyqxmd.com/read/27607196/clinical-radiographic-and-functional-efficacy-of-abatacept-in-routine-care-for-rheumatoid-arthritis-patients-abatacept-leading-trial-for-ra-on-imaging-remission-altair-study
#18
Satoshi Kubo, Kazuhisa Nakano, Shingo Nakayamada, Shintaro Hirata, Shunsuke Fukuyo, Norifumi Sawamukai, Kazuyoshi Saito, Yoshiya Tanaka
OBJECTIVES: To investigate the efficacy and safety of abatacept for treating patients with rheumatoid arthritis (RA) in routine clinical practice and to determine the prognostic factors affecting clinical outcomes. METHODS: We performed a retrospective study of 194 RA patients treated with abatacept. Clinical outcomes at 1 year after the treatment were assessed. Joint damage was assessed by the van der Heijde-modified total Sharp score (mTSS). RESULTS: Of the 194 patients, abatacept was discontinued in 51 patients, resulting in a retention rate at week 52 of 73...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27566473/efficacy-and-safety-of-novel-high-frequency-multi-train-stimulation-for-recording-transcranial-motor-evoked-potentials-in-a-rat-model
#19
Tsuyoshi Deguchi, Shunji Tsutsui, Hiroki Iwahashi, Yukihiro Nakagawa, Munehito Yoshida
Recently, low-frequency multi-train stimulation (MTS) was shown to effectively enhance transcranial motor-evoked potentials (TcMEPs). In contrast, high- frequency double-train stimulation was reported to elicit a marked facilitation. The aim of this study was to evaluate the efficacy of high-frequency MTS in the augmentation of potentials. In addition, we investigated the safety of high-frequency MTS, behaviorally and histologically. TcMEPs were recorded from the triceps surae muscle in 38 rats. A multipulse stimulus was delivered repeatedly at different rates (2, 5, 10, 20, and 50 Hz), and was defined as MTS...
August 26, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27476374/are-ultrasonographic-findings-like-periosteal-and-tendinous-edema-associated-with-medial-tibial-stress-syndrome-a-case-control-study
#20
Marinus Winters, Paulien Bon, Sascha Bijvoet, Eric W P Bakker, Maarten H Moen
OBJECTIVES: Medial tibial stress syndrome (MTSS) is one of the most common sporting injuries. As of yet, the development of effective therapeutic interventions to treat MTSS is hindered by the fact that its pathology is unknown. Our aim was to explore the pathology of MTSS, by assessing whether the presence of MTSS is related to periosteal, bony or tendinous abnormalities in the lower leg. DESIGN: Case-control study. METHODS: Participants with MTSS and athletic control participants were recruited from the same (high-risk) base population...
July 18, 2016: Journal of Science and Medicine in Sport
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