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Preserved ejection fraction heart failure

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https://www.readbyqxmd.com/read/28625377/one-year-mortality-outcomes-and-hospital-readmissions-of-patients-admitted-with-acute-heart-failure-data-from-the-trivandrum-heart-failure-registry-in-kerala-india
#1
Sivadasanpillai Harikrishnan, Ganapathi Sanjay, Anubha Agarwal, N Pratap Kumar, K Krishna Kumar, Charantharayil Gopalan Bahuleyan, Govindan Vijayaraghavan, Sunitha Viswanathan, Madhu Sreedharan, R Biju, N Rajalekshmi, Tiny Nair, Krishnan Suresh, Panniyammakal Jeemon
BACKGROUND: There are sparse data on outcomes of patients with heart failure (HF) from India. The objective was to evaluate hospital readmissions and 1-year mortality outcomes of patients with HF in Kerala, India. METHODS: We followed 1,205 patients enrolled in the Trivandrum Heart Failure Registry for 1 year. A trained research nurse contacted each participant every 3 months using a structured questionnaire which included hospital readmission and mortality information...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624653/giant-ring-mitochondria-in-a-patient-with-heart-failure-and-cerebral-white-matter-disease-due-to-mt-tl1-mitochondrial-gene-mutation
#2
Brian A Houston, Daniel P Judge, Emily Brown, Marc Halushka, Lili A Barouch
BACKGROUND: The presence of giant ring mitochondria on endomyocardial biopsy is rarely reported and does not have a well-defined differential diagnosis. METHODS: We report the case of a 54-year-old man with heart failure with preserved ejection fraction and left ventricular hypertrophy, initially thought to have an infiltrative cardiomyopathy. RESULTS: The patient was found to have extensive vacuolization caused by the presence of giant ring mitochondria on endomyocardial biopsy...
June 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28624483/biomarker-profiles-of-acute%C3%A2-heart%C3%A2-failure%C3%A2-patients-with-a%C3%A2-mid-range-ejection%C3%A2-fraction
#3
Jasper Tromp, Mohsin A F Khan, Robert J Mentz, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G F Cleland, Michael M Givertz, Daniel M Bloomfield, Dirk J van Veldhuisen, Hans L Hillege, Adriaan A Voors, Peter van der Meer
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a reduced ejection fraction [HFrEF]) and preserved (heart failure with a preserved ejection fraction [HFpEF]) ejection fraction. BACKGROUND: Limited data are available on biomarker profiles in acute HFmrEF. METHODS: A panel of 37 biomarkers from different pathophysiological domains (e...
May 31, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28620053/exercise-training-improve-cardiac-autonomic-control-cardiac-function-and-arrhythmogenesis-in-rats-with-preserved-ejection-fraction-heart-failure
#4
David C Andrade, Alexis Arce-Alvarez, Camilo Toledo, Hugo S Diaz, Claudia Lucero, Harold D Schultz, Noah J Marcus, Rodrigo Del Rio
Chronic heart failure is characterized by autonomic imbalance, cardiac dysfunction and arrhythmogenesis. It has been shown that exercise training (ExT) improves central nervous system oxidative stress, autonomic control and cardiac function in heart failure with reduced ejection fraction (HFrEF), however to date no comprehensive studies have addressed the effects of ExT, if any, on oxidative stress in brainstem cardiovascular areas, cardiac autonomic balance, arrhythmogenesis and cardiac function in heart failure with preserved ejection fraction (HFpEF)...
June 15, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28616536/nt-probnp-and-diastolic-left-ventricular-function-in-patients-with-marfan-syndrome
#5
Petra Gehle, Peter N Robinson, Frank Heinzel, Frank Edelmann, Mustafa Yigitbasi, Felix Berger, Volkmar Falk, Burkert Pieske, Ernst Wellnhofer
AIMS: Subclinical diastolic dysfuntion in patients with preclinical heart failure with preserved ejection fraction (HFpEF) has been demonstrated in patients with Marfan syndrome (MFS). We investigated the relationship between diastolic dysfunction and NT-proBNP levels in patients with MFS. METHODS AND RESULTS: NT-proBNP, C-reactive protein (CRP) and diastolic function were assessed in 217 patients with MFS (31 ± 16 y, 110 f. and in 339 patients referred for suspected MFS in whom the diagnosis was ruled out according to the Ghent nosology (30 ± 15 y, 154 f)...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28615366/significance-of-ischemic-heart-disease-in-patients-with-heart-failure-and-preserved-midrange-and-reduced-ejection-fraction-a-nationwide-cohort-study
#6
Ola Vedin, Carolyn S P Lam, Angela S Koh, Lina Benson, Tiew Hwa Katherine Teng, Wan Ting Tay, Oscar Ö Braun, Gianluigi Savarese, Ulf Dahlström, Lars H Lund
BACKGROUND: The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF <40%) is well established, but its pathogenic and prognostic significance in HF with midrange (HFmrEF; EF 40%-50%) and preserved EF (HFpEF; EF ≥50%) has been much less explored. METHODS AND RESULTS: We evaluated 42 987 patients from the Swedish Heart Failure Registry with respect to baseline IHD, outcomes (IHD, HF, cardiovascular events, and all-cause death), and EF change during a median follow-up of 2...
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28611129/microvascular-paradigm-in-heart-failure-with-preserved-ejection-fraction-a-quest-for-proof-of-concept
#7
EDITORIAL
Mark T Waddingham, Walter J Paulus
No abstract text is available yet for this article.
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28611124/endothelial-senescence-contributes-to-heart-failure-with-preserved-ejection-fraction-in-an-aging-mouse-model
#8
Andreas B Gevaert, Hadis Shakeri, Arthur J Leloup, Cor E Van Hove, Guido R Y De Meyer, Christiaan J Vrints, Katrien Lemmens, Emeline M Van Craenenbroeck
BACKGROUND: Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate the role of cellular senescence in HFpEF development. METHODS AND RESULTS: Senescence-accelerated mice (SAM, n=18) and control mice with normal senescence (n=15) were fed normal chow or a high-fat, high-salt diet (WD)...
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28611096/thymosin-beta-4-is-elevated-in-women-with-heart-failure-with-preserved-ejection-fraction
#9
Chester L Drum, Warren K Y Tan, Siew-Pang Chan, Leroy S Pakkiri, Jenny P C Chong, Oi-Wah Liew, Tze-Pin Ng, Lieng-Hsi Ling, David Sim, Kui-Toh G Leong, Daniel P S Yeo, Hean-Yee Ong, Fazlur Jaufeerally, Raymond C C Wong, Ping Chai, Adrian F Low, Pia Davidsson, Mathias Liljeblad, Ann-Sofi Söderling, Li-Ming Gan, Ratan V Bhat, Kristy Purnamawati, Carolyn S P Lam, A Mark Richards
BACKGROUND: Thymosin beta-4 (TB4) is an X-linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF), and its relationship with other cardiovascular biomarkers. We sought to evaluate circulating TB4 in HF patients with preserved (HFpEF) or reduced (HFrEF) ejection fraction compared to non-HF controls. METHODS AND RESULTS: TB4 was measured using a liquid chromatography and mass spectrometry assay in age- and sex-matched HFpEF (n=219), HFrEF (n=219) patients, and controls (n=219) from a prospective nationwide study...
June 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28606099/pulmonary-hemodynamics-and-effects-of-phosphodiesterase-type-5-inhibition-in-heart-failure-a-meta-analysis-of-randomized-trials
#10
In-Chang Hwang, Yong-Jin Kim, Jun-Bean Park, Yeonyee E Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Goo-Yeong Cho, Dae-Won Sohn
BACKGROUND: Previous studies suggested that phosphodiesterase 5 inhibitors (PDE5i) have a beneficial effect in patients with heart failure (HF), although the results were inconsistent. We performed a meta-analysis to evaluate the effect of PDE5i in HF patients, and investigated the relationship between PDE5i effects and pulmonary hemodynamics. METHOD: We searched PubMed, EMBASE and the Cochrane Library for randomized controlled trials (RCTs) that compared PDE5i with placebo in HF with reduced ejection fraction (HFrEF) or HF with preserved EF (HFpEF)...
June 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28603587/heart-failure-after-myocardial-infarction-in-the-era-of-primary-percutaneous-coronary-intervention-mechanisms-incidence-and-identification-of-patients-at-risk
#11
REVIEW
Thomas J Cahill, Rajesh K Kharbanda
Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years HF has been recognised as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to translate into clinical therapies. Primary percutaneous coronary intervention (PPCI) has driven improved early survival after MI, but its impact on the incidence of downstream HF is debated. The effects of PPCI are confounded by the changing epidemiology of MI and HF, with an ageing patient demographic, an increasing proportion of non-ST-elevation myocardial infarction, and the recognition of HF with preserved ejection fraction...
May 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28602367/heart-failure-with-preserved-ejection-fraction-in-older-adults
#12
REVIEW
Bharathi Upadhya, Dalane W Kitzman
Most elderly patients, particularly women, who have heart failure, have a preserved ejection fraction. Patients with this syndrome have severe symptoms of exercise intolerance, frequent hospitalizations, and increased mortality. Despite the importance of heart failure with preserved ejection fraction (HFpEF), the understanding of its pathophysiology is incomplete, and optimal treatment remains largely undefined. Unlike the management of HFrEF, there is a paucity of large evidence-based trials demonstrating morbidity and mortality benefit for the treatment of HFpEF...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28602364/diagnosis-and-management-of-heart-failure-in-older-adults
#13
REVIEW
Gurusher Panjrath, Ali Ahmed
Aging is characterized by heterogeneity, both in health and illness. Older adults with heart failure often have preserved ejection fraction and atypical and delayed clinical manifestations. After diagnosis of heart failure is established, a cause should be sought. The patient's comorbidities may provide clues. An elevated jugular venous pressure is the most reliable clinical sign of fluid volume overload and should be carefully evaluated. Left ventricular ejection fraction must be determined to assess prognosis and guide therapy...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28601914/left-ventricular-ejection-fraction-as-therapeutic-target-is-it-the-ideal-marker
#14
REVIEW
V Katsi, G Georgiopoulos, A Laina, E Koutli, J Parissis, C Tsioufis, P Nihoyannopoulos, D Tousoulis
Heart failure (HF) consists the fastest growing clinical cardiac disease. HF patients are categorized on the basis of underlying left ventricular ejection fraction (LVEF) into HF with preserved EF (HFpEF), reduced LVEF (HFrEF), and mid-range LVEF (HFmrEF). While LVEF is the most commonly used surrogate marker of left ventricular (LV) systolic function, the implementation of two-dimensional echocardiography in estimating this parameter imposes certain caveats on current HF classification. Most importantly, LVEF could fluctuate in repeated measurements or even recover after treatment, thus blunting the borders between proposed categories of HF and enabling upward classification of patients...
June 10, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28600367/development-and-validation-of-a-risk-stratification-model-for-prediction-of-disability-and-hospitalisation-in-patients-with-heart-failure-a-study-protocol
#15
Luis García-Olmos, Francisco Rodríguez-Salvanés, Maurice Batlle-Pérez, Río Aguilar-Torres, Carlos Porro-Fernández, Alfredo García-Cabello, Montserrat Carmona, Sergio Ruiz-Alonso, Sofía Garrido-Elustondo, Ángel Alberquilla, Luis María Sánchez-Gómez, Ricardo Sánchez de Madariaga, Elena Monge-Navarrete, Luis Benito-Ortiz, Nicolás Baños-Pérez, Amaya Simón-Puerta, Ana Belén López Rodríguez, Miguel Ángel Martínez-Álvarez, María Ángeles Velilla-Celma, María Isabel Bernal-Gómez
BACKGROUND: Chronic heart failure (CHF) reduces quality of life and causes hospitalisation and death. Identifying predictive factors of such events may help change the natural history of this condition. AIM: To develop and validate a stratification system for classifying patients with CHF, according to their degree of disability and need for hospitalisation due to any unscheduled cause, over a period of 1 year. METHODS AND ANALYSIS: Prospective, concurrent, cohort-type study in two towns in the Madrid autonomous region having a combined population of 1 32 851...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28599827/late-detection-of-left-ventricular-dysfunction-using-two-dimensional-and-three-dimensional-speckle-tracking-echocardiography-in-patients-with-history-of-nonsevere-acute-myocarditis
#16
Thibault Caspar, Marie Fichot, Mickaël Ohana, Soraya El Ghannudi, Olivier Morel, Patrick Ohlmann
BACKGROUND: Acute myocarditis (AM) often involves the left ventricular (LV) subepicardium that might be displayed by cardiac magnetic resonance even late after the acute phase. In the absence of global or regional LV dysfunction, conventional transthoracic echocardiography (TTE) does not accurately identify tissue sequelae of AM. We sought to evaluate the diagnostic value of two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography to identify patients with a history of AM with preserved LV ejection fraction (LVEF)...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28597765/poor-survival-in-patients-with-scleroderma-and-pulmonary-hypertension-due-to-heart-failure-with-preserved-ejection-fraction
#17
Khalil I Bourji, Benjamin W Kelemen, Stephen C Mathai, Rachel L Damico, Todd M Kolb, Valentina Mercurio, Franco Cozzi, Ryan J Tedford, Paul M Hassoun
Pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) has been poorly studied in patients with systemic sclerosis (SSc). We sought to compare clinical characteristics and survival of SSc patients with PH-HFpEF (SSc-PH-HFpEF) versus pulmonary arterial hypertension (SSc-PAH). We hypothesized that patients with SSc-PH-HFpEF have a similar poor overall prognosis compared with patients with SSc-PAH when matched for total right ventricular load. The analysis included 117 patients with SSc-PH (93 with SSc-PAH versus 24 with SSc-PH-HFpEF) enrolled prospectively in the Johns Hopkins PH Registry...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28597497/right-ventricular-dysfunction-in-left-sided-heart-failure-with-preserved-versus-reduced-ejection-fraction
#18
Lena Bosch, Carolyn S P Lam, Lingli Gong, Siew Pang Chan, David Sim, Daniel Yeo, Fazlur Jaufeerally, Kui Toh Gerard Leong, Hean Yee Ong, Tze Pin Ng, Arthur Mark Richards, Fatih Arslan, Lieng H Ling
BACKGROUND: Right ventricular (RV) dysfunction is recognized as a major prognostic factor in left-sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with preserved (HFpEF) vs. reduced ejection fraction (HFrEF) is unclear. METHODS AND RESULTS: Right ventricular longitudinal strain (RVLS), tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) were determined by echocardiography in 657 age- and gender-matched groups of patients with HFpEF [left ventricular ejection fraction (LVEF) ≥50%; n=219] and HFrEF (LVEF <50%; n=219) and in controls without HF (n=219) from an Asian population-based cohort study...
June 8, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28592726/effect-of-dipeptidyl-peptidase-4-inhibitors-on-cardiovascular-outcome-and-cardiac-function-in-patients-with-diabetes-and-heart-failure%C3%A3-insights-from-the-ibaraki-cardiac-assessment-study-heart-failure-icas-hf-registry
#19
Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizu, Isao Nishi, Yoshie Hamada-Harimura, Tomoko Machino-Ohtsuka, Kimi Sato, Seika Sai, Akinori Sugano, Kenichi Obara, Kazutaka Aonuma
BACKGROUND: Although experimental animal studies report many pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP-4i), their prognostic value has not been demonstrated in clinical trials.Methods and Results:Among 838 prospectively enrolled heart failure (HF) patients hospitalized for acute decompensated HF, 79 treated with DPP-4i were compared with 79 propensity score-matched non-DPP-4i diabetes mellitus (DM) patients. The primary endpoint was all-cause mortality; the secondary endpoint was a composite of cardiovascular death and hospitalization...
June 6, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28588021/accelerometer-measured-daily-activity-in-heart-failure-with-preserved-ejection-fraction-clinical-correlates-and-association-with-standard-heart-failure-severity-indices
#20
David Snipelisky, Jacob Kelly, James A Levine, Gabriel A Koepp, Kevin J Anstrom, Steven E McNulty, Rosita Zakeri, G Michael Felker, Adrian F Hernandez, Eugene Braunwald, Margaret M Redfield
BACKGROUND: Daily physical activity assessed by accelerometers represents a novel method to assess the impact of interventions on heart failure (HF) patients' functional status. We hypothesized that daily activity varies by patient characteristics and correlates with established measures of HF severity in HF with preserved ejection fraction. METHODS AND RESULTS: In this ancillary study of the NEAT-HFpEF trial (Nitrate's Effects on Activity Tolerance in HF With Preserved Ejection Fraction), average daily accelerometer units (ADAU) and hours active per day were assessed during a 14-day period before starting isosorbide mononitrate or placebo (n=110)...
June 2017: Circulation. Heart Failure
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