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Lung bronchoscopy

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https://www.readbyqxmd.com/read/28932591/a-case-of-tuberculosis-reactivation-suspected-of-cancer-progression-during-oral-tyrosine-kinase-inhibitor-treatment-in-a-patient-diagnosed-as-non-small-cell-lung-cancer
#1
Hwa Young Lee, Jin Woo Kim, Chang Dong Yeo
We report a first case of a patient experiencing reactivation of pulmonary tuberculosis (TB) during treatment of oral tyrosine kinase inhibitor (TKI) with non-small cell lung cancer (NSCLC). A 44-year-old male patient visited the hospital with cough. He had been treated with erlotinib (oral TKI) for 8 months after being diagnosed as NSCLC with sensitive epidermal growth factor receptor mutation in our clinic. At initial chest imaging, the patient had fibroatelectatic calcified granuloma in the right upper lobe (RUL) apex as well as 1...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932570/the-technique-of-endoscopic-airway-tumor-treatment
#2
REVIEW
Simone Scarlata, Lello Fuso, Gabriele Lucantoni, Francesco Varone, Daniele Magnini, Raffaele Antonelli Incalzi, Gianni Galluccio
More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in advanced cancerous lesions and cure of early lung cancer. Bronchoscopic management is also indicated for all those patients suffering from benign or minimally invasive neoplasm who are not suitable for surgery due to their clinical conditions...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28914826/pulmonary-alveolar-proteinosis-a-case-report
#3
Luis Alberto Concepción-Urteaga, Luis Alejandro Rodríguez-Hidalgo, Jorge Luis Cornejo-Portella, Oscar Neri Alquizar-Horna, Daniel Anderson Aguilar-Villanueva, Marcio José Concepción-Zavaleta, Mario Gustavo Azañero-Luján
INTRODUCTION: Pulmonary alveolar proteinosis is a rare, diffuse interstitial lung disease, characterized by alveolar obstruction due to the accumulation of pulmonary surfactant. CLINICAL PRESENTATION: A 30-year-old male with progressively worsening dyspnea and non-productive cough for one year. He was a sugar cane plantation worker and had prior recurrent respiratory infections. Physical exam revealed cyanosis, and bilateral coarse and fine rales. Chest computed tomography showed diffuse crazy paving pattern...
September 14, 2017: Medwave
https://www.readbyqxmd.com/read/28913160/pancoast-tumor-approach-through-oesophagus
#4
Eritjan Tashi, Perlat Kapisyzi, Daniela Xhemalaj, Alma Andoni, Ilir Peposhi
Patient with Pancoast Tumor usually present in advanced stage of the disease which requires chemotherapy and radiotherapy as options of treatment. Histologic confirmation is a key for further treatment of these patients. Normally in bronchoscopy the lesion can't be visualised and in result making biopsy difficult to perform. Transthoracic biopsy through computed tomography poses anatomic difficulties and not always the pulmonary lesion can be reached. We report a case of pancoast tumor in a 68 year old male who presented with left arm pain and upper lobe increased density mass in chest x ray...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28906034/small-airway-disease-a-different-phenotype-of-early-stage-copd-associated-with-biomass-smoke-exposure
#5
Dongxing Zhao, Yumin Zhou, Changbin Jiang, Zhuxiang Zhao, Fang He, Pixin Ran
BACKGROUND AND OBJECTIVE: Chronic exposure to biomass smoke (BS) can significantly compromise pulmonary function and lead to chronic obstructive pulmonary disease (COPD). To determine whether BS exposure induces a unique phenotype of COPD from an early stage, with different physiopathological features compared with COPD associated with smoking (cigarette-smoke (CS) COPD), we assessed the physiopathology of early COPD associated with BS exposure (BS COPD) by incorporating spirometry, high-resolution computed tomography (HRCT) imaging, bronchoscopy and pathological examinations...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28904436/strongyloid-hyperinfection-in-a-patient-with-immunocompromised-chronic-kidney-disease
#6
S Hedau, V P Reddy, S D Mondhe, J V Devana
Strongyloid hyperinfection is seen in immunocompromised individuals with underlying lung disease. The use of immunosuppressive drugs is an important risk factor. We report a case of IgA nephropathy with crescent, started on glucocorticoid and mycophenolate mofetil. He presented with bilateral lung opacities with breathlessness. As the breathlessness was not improving, despite adequate ultrafiltration, bronchoscopy was done. Bronchoalveolar lavage fluid examination showed the presence of strongyloid larvae, which was later demonstrated in stool also...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28900554/primary-epithelioid-angiosarcoma-of-lung-radiologic-and-clinicopathologic-correlation
#7
Fung Him Ng, San Ming Yu, Ophelia Ka Heng Wai, James Chi Sang Chan
Primary pulmonary angiosarcoma is extremely rare. It is often characterized by a clinically indolent course and delayed diagnosis. To date, there have been <20 cases reported. By far, little article correlates the clinical presentation, the imaging findings with the pathology. The authors present a case of middle-aged gentleman with primary pulmonary epithelioid angiosacroma which we initially thought as tuberculosis (TB) infection. A 60-year-old gentleman, with a history of 6 months on and off blood stained sputum, was admitted for an episode of massive hemoptysis...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28891836/feasibility-and-safety-of-flexible-bronchoscopy-performed-via-tracheal-tubes-in-patients-with-tracheostomies-a-retrospective-single-center-experience
#8
Gustavo Ferrer, Chi Chan Lee, Sameer Shaharyar, Osman Perez, Molly Moor, Frank Gomez, Fanny Tse, Hamid Feiz, Mauricio Danckers
BACKGROUND: Flexible bronchoscopy (FB) is commonly performed to assess, diagnose, and treat patients with respiratory disease, and is typically performed via transnasal or transoral approaches. FB can be performed via tracheal tubes in patients with tracheostomies; however, the safety and technical feasibility has not been established. The present study evaluates the safety and feasibility of performing FB via tracheal tubes. MATERIALS AND METHODS: A total of 45 patients underwent 56 procedures involving FB via tracheal tubes at a single institution from November 2013 to November 2014 and were included in this retrospective case series...
September 7, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28889136/electro-navigational-bronchoscopy-for-bilateral-peripheral-lung-lesions-a-case-report
#9
A H Faisal, A W Sopian, H Tidi
Electromagnetic navigational bronchoscopy (ENB), one of the methods of navigational bronchoscopy is an advanced diagnostic tool allowing tissue sampling at the lung peripheries which were previously accessible only by computed tomography (CT) guidance or video-assisted thoracoscopic surgery (VATS). We report a 53-year-old man who presented with a cough and dyspnea with constitutional symptoms for one month. CT thorax revealed multiple bilateral peripheral lung nodules and there were no endobronchial lesions on flexible bronchoscopy...
August 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28886329/a-case-of-igg4-related-retroperitoneal-fibrosis-with-multiple-involvement
#10
Y-K Zheng, N-Y Gu, J Wu, X Fang, C Zhang, Q-Y Li
To increase awareness of IgG4-related retroperitoneal fibrosis (IgG4-RRPF) and reduce clinical misdiagnosis. We report a 79-year-old man with multiple organs involvement of IgG4-RRPF, who developed right lower extremity edema, hemoptysis and fever. The abdomen computed tomography (CT) scan image showed lymph nodes enlargement. The positron emission tomography/CT scan image showed pancreatic malignancy with multiple nodal lymph node metastasis, lung fibroblast proliferation, and right lung apex bullae. The chest CT scan image showed pulmonary multiple lymph nodes with calcification in the mediastinum...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28877936/alterations-in-bronchial-airway-microrna-expression-for-lung-cancer-detection
#11
Ana B Pavel, Joshua D Campbell, Gang Liu, David A Elashoff, Steven M Dubinett, Kate Smith, Duncan Whitney, Marc E Lenburg, Avrum E Spira
We have previously shown that gene-expression alterations in normal-appearing bronchial epithelial cells can serve as a lung cancer detection biomarker in smokers. Given that microRNAs regulate airway gene-expression responses to smoking, we evaluated whether microRNA-expression is also altered in the bronchial epithelium of smokers with lung cancer. Using epithelial brushings from the mainstem bronchus of patients undergoing bronchoscopy for suspected lung cancer (as part of the AEGIS-1/2 clinical trials), we profiled microRNA-expression via small-RNA sequencing from 347 current and former smokers for which gene-expression data was also available...
September 6, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28877801/using-electromagnetic-navigation-bronchoscopy-and-dye-injection-to-aid-in-video-assisted-lung-resection
#12
Jordan Brown, Thomas J Lee, Theresa Joiner, William Wrightson
Small (2 cm) peripheral lung lesions and ground glass opacities remain a difficult subset of lung lesions for the diagnosis and management of lung cancer. Surgical biopsy is more difficult for these lesions because intraoperative localization has to be made without the aid of direct visualization or manual palpation. Electromagnetic navigation bronchoscopy can be used in the operating room to identify a small peripheral lesion and marked using an injection of methylene blue, which can be seen on the visceral pleura of the lung...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28875147/protected-sampling-is-preferable-in-bronchoscopic-studies-of-the-airway-microbiome
#13
Rune Grønseth, Christine Drengenes, Harald G Wiker, Solveig Tangedal, Yaxin Xue, Gunnar Reksten Husebø, Øistein Svanes, Sverre Lehmann, Marit Aardal, Tuyen Hoang, Tharmini Kalananthan, Einar Marius Hjellestad Martinsen, Elise Orvedal Leiten, Marianne Aanerud, Eli Nordeide, Ingvild Haaland, Inge Jonassen, Per Bakke, Tomas Eagan
The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with small-volume lavage (SVL) through the working channel, protected bronchoalveolar lavage (PBAL) and bilateral protected specimen brush (PSB) sampling. Subjects also provided an oral wash (OW) sample, and negative control samples were gathered for each bronchoscopy procedure. DNA encoding bacterial 16S ribosomal RNA was sequenced and bioinformatically processed to cluster into operational taxonomic units (OTU), assign taxonomy and obtain measures of diversity...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28868011/esophagobronchial-fistula-in-a-patient-with-squamous-cell-carcinoma-of-the-lung-a-case-report
#14
Taichi Ozeki, Michiko Asano, Nobukazu Fujimoto, Jun Nishimura, Kenji Takada, Yosuke Miyamoto, Yasuko Fuchimoto, Sae Wada, Shinji Ozaki, Takumi Kishimoto
A 73-year-old man was referred to our hospital after a 2-week history of bloody sputum and cough. Computed tomography (CT) images of the chest showed a mass grouped with mediastinal lymph nodes, and bronchoscopy showed a projecting mass in the right main bronchus. After a transbronchial biopsy, the patient was diagnosed with squamous cell carcinoma (T4N2M0 stage IIIB). The patient was treated with systemic chemotherapy, consisting of cisplatin (40 mg/m(2), days 1 and 8) and docetaxel (30 mg/m(2), days 1 and 8), and concurrent thoracic irradiation at a daily dose of 2 Gy...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28866847/successful-conservative-management-of-an-anastomotic-airway-dehiscence-at-the-left-main-bronchus-following-bilateral-cadaveric-lung-transplantation
#15
Ryo Miyata, Toyofumi F Chen-Yoshikawa, Masatsugu Hamaji, Fumiaki Gochi, Hideki Motoyama, Toshi Menju, Akihiro Aoyama, Toshihiko Sato, Makoto Sonobe, Hiroshi Date
There is a dearth of data on management of anastomotic airway dehiscence following lung transplantation. Herein we report a case of successful conservative management of an anastomotic airway dehiscence after cadaveric donor lung transplantation. A 41-year-old woman with primary ciliary dyskinesia underwent cadaveric bilateral lung transplantation without cardiopulmonary bypass. On the postoperative day 25, left pneumothorax developed and bronchoscopy demonstrated a localized anastomotic dehiscence at the left main bronchus...
September 2, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28861333/successful-treatment-of-limited-stage-small-cell-lung-cancer-in-the-right-mainstem-bronchus-by-a-combination-of-chemotherapy-and-argon-plasma-coagulation
#16
Takayuki Takeda, Hideki Itano, Mayumi Takeuchi, Yurika Nishimi, Masahiko Saitoh, Sorou Takeda
The current standard-of-care treatment for patients with limited-stage small-cell lung cancer (SCLC) is concurrent chemoradiotherapy for local and systemic control. However, standard-of-care treatment strategies have not been established for those with limited-stage SCLC who have a history of thoracic radiotherapy due to concerns with complications associated with radiation overdose. A 37-year-old male developed an aspergilloma in the postoperative left thoracic space after he was treated with concurrent chemoradiotherapy for mediastinal type lung adenocarcionoma and subsequent left upper lobectomy for heterochronous dual adenocarcinoma...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28860145/the-respiratory-tract-microbial-biogeography-in-alcohol-use-disorder
#17
Derrick R Samuelson, Ellen L Burnham, Vincent J Maffei, R William Vandivier, Eugene E Blanchard, Judd E Shellito, Meng Luo, Christopher M Taylor, David A Welsh
RATIONALE: Individuals with alcohol use disorders (AUDs) are at an increased risk of pneumonia and acute respiratory distress syndrome. Data of the lung microbiome in the setting of AUDs are lacking. The objective of this study was to determine the microbial biogeography of the upper and lower respiratory tract in individuals with AUDs compared to non-AUD subjects. MATERIALS AND METHODS: Gargle, protected bronchial brush, and bronchoalveolar lavage specimens were collected during research bronchoscopies...
August 31, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28859661/triple-synchronous-primary-lung-cancer-a-case-report-and-review-of-the-literature
#18
Muhammad Kashif, Puvanalingam Ayyadurai, Luong Thanha, Misbahuddin Khaja
BACKGROUND: Multiple primary lung cancer may present in synchronous or metachronous form. Synchronous multiple primary lung cancer is defined as multiple lung lesions that develop at the same time, whereas metachronous multiple primary lung cancer describes multiple lung lesions that develop at different times, typically following treatment of the primary lung cancer. Patients with previously treated lung cancer are at risk for developing metachronous lung cancer, but with the success of computed tomography and positron emission tomography, the ability to detect both synchronous and metachronous lung cancer has increased...
September 1, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28846557/cytomegalovirus-viral-load-in-bronchoalveolar-lavage-to-diagnose-lung-transplant-associated-cmv-pneumonia
#19
Isabelle Paula Lodding, Hans Henrik Schultz, Jens-Ulrik Jensen, Nikolai Kirkby, Michael Perch, Claus Andersen, Jens D Lundgren, Martin Iversen
BACKGROUND: The diagnostic yield for cytomegalovirus (CMV) PCR viral load in Bronchoalveolar Lavage (BAL) or in plasma to diagnose CMV pneumonia in lung transplant recipients remains uncertain, and was investigated in a large cohort of consecutive lung transplant recipients. METHODS: Bronchoscopies within the first year of lung transplantation with CMV detectable in BAL by PCR (ie, viral load ≥273 IU/mL) were included (66 recipients; 145 bronchoscopies); at each bronchoscopy episode 2 independent experts reviewed clinical and laboratory information to determine whether the patient at that time fulfilled the criteria for CMV pneumonia per current international recommendations...
August 24, 2017: Transplantation
https://www.readbyqxmd.com/read/28844207/a-novel-presentation-of-mycobacterium-avium-complex-in-a-recipient-of-a-lung-transplant-a-case-report
#20
Leah Cohen, Jeannette Guarner, William R Hunt
BACKGROUND: Lung transplantation remains an important potential therapeutic option for end-stage lung disease. It can improve quality of life and in some cases be a life-lengthening therapy. Despite the possible benefits, there are also many potential complications following transplantation. Here we describe a novel presentation of nontuberculous mycobacterium manifesting as an endobronchial mass developing 4 years after lung transplantation. CASE PRESENTATION: A 66-year-old African-American woman presented with progressive dyspnea, cough, and persistent wheezing of 2 months' duration...
August 28, 2017: Journal of Medical Case Reports
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