keyword
MENU ▼
Read by QxMD icon Read
search

memory and anaesthesia

keyword
https://www.readbyqxmd.com/read/27914975/techniques-for-chronic-monitoring-of-brain-activity-in-freely-moving-sheep-using-wireless-longitudinal-eeg-recording
#1
N Perentos, A U Nicol, A Q Martins, J E Stewart, P Taylor, A J Morton
BACKGROUND: Large mammals with complex central nervous systems offer new possibilities for translational research into basic brain function. Techniques for monitoring brain activity in large mammals, however, are not as well developed as they are in rodents. NEW METHOD: We have developed a method for chronic monitoring of electroencephalographic (EEG) activity in unrestrained sheep. We describe the methods for behavioural training prior to implantation, surgical procedures for implantation, a protocol for reliable anaesthesia and recovery, methods for EEG data collection, as well as data pertaining to suitability and longevity of different types of electrodes...
November 30, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27842634/a-review-of-the-peri-operative-management-of-paediatric-burns-identifying-adverse-events
#2
H Rode, C Brink, K Bester, M P Coleman, T Baisey, R Martinez
BACKGROUND: Burn injuries are common in poverty-stricken countries. The majority of patients with large and complex burns are referred to burn centres. Of the children who qualify for admission, according to burn admission criteria, about half require some kind of surgical procedure to obtain skin cover. These range from massive full-thickness fire burns to skin grafts for small, residual unhealed wounds. Burn anaesthetic procedures are of the most difficult to perform and are known for high complication rates...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27755648/anaesthetic-interventions-for-prevention-of-awareness-during-surgery
#3
REVIEW
Anthony G Messina, Michael Wang, Marshall J Ward, Chase C Wilker, Brett B Smith, Daniel P Vezina, Nathan Leon Pace
BACKGROUND: General anaesthesia is usually associated with unconsciousness. 'Awareness' is when patients have postoperative recall of events or experiences during surgery. 'Wakefulness' is when patients become conscious during surgery, but have no postoperative recollection of the period of consciousness. OBJECTIVES: To evaluate the efficacy of two types of anaesthetic interventions in reducing clinically significant awareness:- anaesthetic drug regimens; and- intraoperative anaesthetic depth monitors...
October 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27624061/the-effect-of-anaesthesia-on-the-infant-brain
#4
Andrew Davidson
Pre-clinical studies have consistently found that most general anaesthetics produce accelerated apoptosis in the developing brain. The effect has been seen in species ranging from the nematode to the non-human primate. A variety of other effects are also seen. There is also some evidence that animals exposed to anaesthesia are at increased risk of deficits in memory and learning. The effects are only seen with prolonged exposure. There are numerous problems in translating these findings to human clinical scenarios...
September 10, 2016: Early Human Development
https://www.readbyqxmd.com/read/27572468/naringenin-pre-treatment-inhibits-neuroapoptosis-and-ameliorates-cognitive-impairment-in-rats-exposed-to-isoflurane-anesthesia-by-regulating-the-pi3-akt-pten-signalling-pathway-and-suppressing-nf-%C3%AE%C2%BAb-mediated-inflammation
#5
Fu-Zhou Hua, Jun Ying, Jing Zhang, Xi-Feng Wang, Yan-Hui Hu, Ying-Ping Liang, Qin Liu, Guo-Hai Xu
The volatile anaesthetic isoflurane is one of the most frequently employed general anaesthetics in neonates, children and adults. Accumulating evidence demonstrated that exposure to anaesthetics is associated with widespread neurodegeneration and cognitive impairment. Thus, the identification and development of compounds capable of preventing or reducing these adverse effects is of great clinical importance. For this purpose, the present study aimed to assess the effects of a flavonoid, naringenin, on isoflurane-induced neuroapoptosis and cognitive impairment...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27569857/hippocampal-and-striatal-m1-muscarinic-acetylcholine-receptors-are-down-regulated-following-bilateral-vestibular-loss-in-rats
#6
Phillip Aitken, Alice Benoit, Yiwen Zheng, Bruno Philoxene, Anne Le Gall, Pierre Denise, Stephane Besnard, Paul F Smith
Permanent vestibular loss has detrimental effects on the hippocampus, resulting in a disruption to spatial learning and memory, hippocampal theta rhythm and place cell field spatial coherence. Little is known about the vestibular system-related hippocampal cholinergic transmission. Since the pharmacological blockade of muscarinic acetylcholine (ACh) receptors within the hippocampus produces deficits in learning and memory, we hypothesized that ACh receptors may at least partly support the integration of vestibular input...
December 2016: Hippocampus
https://www.readbyqxmd.com/read/27502769/the-post-anaesthesia-n-acetylcysteine-cognitive-evaluation-panacea-trial-study-protocol-for-a-randomised-controlled-trial
#7
David R Skvarc, Olivia M Dean, Linda K Byrne, Laura J Gray, Kathryn Ives, Stephen E Lane, Matthew Lewis, Cameron Osborne, Richard Page, Douglas Stupart, Alyna Turner, Michael Berk, Andrew J Marriott
BACKGROUND: Some degree of cognitive decline after surgery occurs in as many as one quarter of elderly surgical patients, and this decline is associated with increased morbidity and mortality. Cognition may be affected across a range of domains, including memory, psychomotor skills, and executive function. Whilst the exact mechanisms of cognitive change after surgery are not precisely known, oxidative stress and subsequent neuroinflammation have been implicated. N-acetylcysteine (NAC) acts via multiple interrelated mechanisms to influence oxidative homeostasis, neuronal transmission, and inflammation...
2016: Trials
https://www.readbyqxmd.com/read/27501155/cognitive-decline-in-the-elderly-after-surgery-and-anaesthesia-results-from-the-oxford-project-to-investigate-memory-and-ageing-optima-cohort
#8
D Patel, A D Lunn, A D Smith, D J Lehmann, K L Dorrington
Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) years, of whom 109 had moderate or major surgery during a median (IQR) follow-up of 4.1 (2.0-7.6) years. Cognitive decline was more rapid in people who on recruitment were: older, p = 0.0003; male, p = 0.027; had worse cognition, p < 0.0001; or carried the ε4 allele of apoliprotein E (APOEε4), p = 0...
October 2016: Anaesthesia
https://www.readbyqxmd.com/read/27252027/ketamine-alone-or-combined-with-midazolam-or-dexmedetomidine-does-not-affect-anxiety-like-behaviours-and-memory-in-adult-wistar-rats
#9
Ana Magalhães, Ana Valentim, Carlos Venâncio, Mariana Pereira, Pedro Melo, Teresa Summavielle, Luis Antunes
Ketamine administration has been associated with controversial behavioural impairments and psychotic episodes. Even though ketamine alone and in combination with midazolam or dexmedetomidine are frequently used in laboratory animals, the side-effects of such protocols are not well known. Therefore, our aim was to evaluate the effects of ketamine alone and in combination with midazolam or dexmedetomidine on emotional reactivity, as well as the effects on learning and memory in adult rats at least 48 h after anaesthesia...
June 1, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27147542/inhibiting-nadph-oxidase-protects-against-long-term-memory-impairment-induced-by-neonatal-sevoflurane-exposure-in-mice
#10
Z Sun, M Satomoto, Y U Adachi, H Kinoshita, K Makita
BACKGROUND: Neonatal exposure to anaesthetics such as sevoflurane has been reported to result in behavioural deficits in rodents. However, while oxidative injury is thought to play an underlying pathological role, the mechanisms of neurotoxicity remain unclear. In the present study, we investigated whether the NADPH oxidase inhibitor apocynin protects against long-term memory impairment produced by neonatal sevoflurane exposure in mice. METHODS: Postnatal day six mice were divided into four groups; (1) non-anaesthesia, (2) intraperitoneal apocynin (50 mg kg(-1)) treatment, (3) 3% sevoflurane exposure for 6 h, and (4) apocynin treatment combined with sevoflurane exposure...
July 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27031602/non-human-primates-in-neuroscience-research-the-case-against-its-scientific-necessity
#11
REVIEW
Jarrod Bailey, Kathy Taylor
Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial human benefit. Here we review these claims of benefit, specifically in neuroscience, and show that: a) there is a default assumption of their human relevance and benefit, rather than robust evidence; b) their human relevance and essential contribution and necessity are wholly overstated; c) the contribution and capacity of non-animal investigative methods are greatly understated; and d) confounding issues, such as species differences and the effects of stress and anaesthesia, are usually overlooked...
March 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/26994383/prefrontal-left-dominant-hemisphere-gamma-and-delta-oscillators-in-general-anaesthesia-with-volatile-anaesthetics-during-open-thoracic-surgery
#12
Beata Saniova, Michal Drobny, Eva Drobna, Julian Hamzik, Erika Bakosova, Martin Fischer
OBJECTIVES: The main objective was to indicate sufficient general anaesthesia (GA) inhibition for negative experience rejection in GA. PATIENTS AND METHODS: We investigated the group of patients (n = 17, mean age 63.59 years, 9 male--65.78 years, 8 female - 61.13 years) during GA in open thorax surgery and analyzed EEG signal by power spectrum (pEEG) delta (DR), and gamma rhythms (GR). EEG was performed: OPO - the day before surgery and in surgery phases OP1-OP5 during GA...
2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/26888959/post-traumatic-amnesia-and-confusional-state-hazards-of-retrospective-assessment
#13
REVIEW
Daniel Friedland, Michael Swash
Retrospective assessment of post-traumatic amnesia (PTA) must take into account factors other than traumatic brain injury (TBI) which may impact on memory both at the time of injury and subsequent to the injury. These include analgesics, anaesthesia required for surgery, and the development of acute or post-traumatic stress disorder. This is relevant in clinical and medicolegal settings. Repeated assessments of the post-injury state, involving tests for continuing amnesia, risk promoting recall of events suggested by the examiner, or generating confabulations...
October 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26848276/neuroprotective-effects-against-pocd-by-photobiomodulation-evidence-from-assembly-disassembly-of-the-cytoskeleton
#14
REVIEW
Ann D Liebert, Roberta T Chow, Brian T Bicknell, Euahna Varigos
Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia and surgery in elderly patients. While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheimer's disease. Anesthetics have been implicated in POCD, as has neuroinflammation, as indicated by cytokine inflammatory markers. Photobiomodulation (PBM) is an effective treatment for a number of conditions, including inflammation. PBM also has a direct effect on microtubule disassembly in neurons with the formation of small, reversible varicosities, which cause neural blockade and alleviation of pain symptoms...
2016: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/26789130/the-root-canal-treatment-of-a-dilacerated-mandibular-premolar-using-a-novel-instrumentation-approach-a-case-report
#15
A Chaniotis, C Filippatos
To report on a novel method to instrument a dilacerated double curved mandibular premolar SUMMARY: A 45-year-old female was referred suffering from diffuse pain emanating from the mandibular right quadrant. The second premolar (tooth 45) was diagnosed with symptomatic irreversible pulpitis. The radiographic examination revealed a dilacerated s-shaped root configuration, with 2 severe curvatures of less than 2 mm radius. Under local anaesthesia and rubber dam isolation, a glide path was created until a size 10 K-file reached working length...
January 20, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/26665203/-the-risk-of-general-anaesthesia-and-sedation-in-the-older-people
#16
REVIEW
M A E M Oomens, L H D Booij, J A Baart
Temporary memory problems and aggravation of pre-existing memory disorders may occur after treatment under general anaesthesia. A frequency of postoperative cognition disorders between 10 and 50% has been identified in the literature. Risk factors for the occurrence of postoperative memory disorders are advanced age, low level of education, intellectual comorbidity, the onset of dementia and other neurodegenerative disorders, existing sleep disorders and the experience of postoperative pain. The morphological changes seen in the brain after general anaesthesia are similar to the changes occurring in Alzheimer's disease...
December 2015: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/26489663/study-protocol-for-the-randomised-controlled-trial-ketamine-augmentation-of-ect-to-improve-outcomes-in-depression-ketamine-ect-study
#17
RANDOMIZED CONTROLLED TRIAL
Liam Trevithick, R Hamish McAllister-Williams, Andrew Blamire, Tim Branton, Ross Clark, Darragh Downey, Graham Dunn, Andrew Easton, Rebecca Elliott, Clare Ellwell, Katherine Hayden, Fiona Holland, Salman Karim, Jo Lowe, Colleen Loo, Rajesh Nair, Timothy Oakley, Antony Prakash, Parveen K Sharma, Stephen R Williams, Ian M Anderson
BACKGROUND: There is a robust empirical evidence base supporting the acute efficacy of electroconvulsive therapy (ECT) for severe and treatment resistant depression. However, a major limitation, probably contributing to its declining use, is that ECT is associated with impairment in cognition, notably in anterograde and retrograde memory and executive function. Preclinical and preliminary human data suggests that ketamine, used either as the sole anaesthetic agent or in addition to other anaesthetics, may reduce or prevent cognitive impairment following ECT...
October 21, 2015: BMC Psychiatry
https://www.readbyqxmd.com/read/26174293/memory-and-awareness-in-anaesthesia
#18
EDITORIAL
J Kurata, H C Hemmings
No abstract text is available yet for this article.
July 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/26083842/-waking-up-during-general-anaesthesia
#19
REVIEW
Ronald D L Akkerman, Johannes T A Knape
Awareness with recall is defined as 'both conscious experience and memory of events during surgery'. Perceptions of sound, pain or paralysis and assimilation of these in the memory can lead to post-traumatic stress disorder. Prospective studies report an incidence of 0.1-1%. Risk factors include those circumstances that result in under-dosing of anaesthetic agents relative to the patient's specific requirement. A lack of reliable monitoring of depth of anaesthesia is a result of our limited knowledge of the effect of anaesthetics on consciousness and memory...
2015: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/26067401/paper-or-plastic-simulation-based-evaluation-of-two-versions-of-a-cognitive-aid-for-managing-pediatric-peri-operative-critical-events-by-anesthesia-trainees-evaluation-of-the-society-for-pediatric-anesthesia-emergency-checklist
#20
LETTER
Scott C Watkins, Shilo Anders, Anna Clebone, Elisabeth Hughes, Laura Zeigler, Vikram Patel, Yaping Shi, Matthew S Shotwell, Matthew McEvoy, Matthew B Weinger
Cognitive aids (CA), including emergency manuals and checklists, are tools designed to assist users in prioritizing and performing complex tasks during time sensitive, high stress situations (Marshall in Anesth Analgesia 117(5):1162-1171, 2013; Marshall and Mehra in Anaesthesia 69(7):669-677, 2014). The society for pediatric anesthesia (SPA) has developed a series of emergency checklists tailored for use by pediatric perioperative teams that cover a wide range of intraoperative critical events (Shaffner et al...
June 2016: Journal of Clinical Monitoring and Computing
keyword
keyword
55069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"