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memory and anaesthesia

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https://www.readbyqxmd.com/read/29920356/clitoria-ternatea-l-rootextract-ameliorated-the-cognitive-and-hippocampal-long-term-potentiation-deficits-induced-by-chronic-cerebral-hypoperfusion-in-the-rat
#1
Thenmoly Damodaran, Byorn Wei Liang Tan, Ping Liao, Surash Ramanathan, Lim Gin Keat, Zurina Hassan
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea L. (CT), commonly known as Butterfly pea, is used in Indian Ayurvedic medicine to promote brain function and treat mental disorders. Root of CT has been proven to enhance memory, but its role in an animal model of chronic cerebral hypoperfusion (CCH), which has been considered as a major cause of brain disorders, has yet to be explored. AIM OF THE STUDY: To assess the motor and cognitive effects of acute oral administration of CT root methanolic extract and hippocampal long-term plasticity in the CA1 region of the CCH rat model...
June 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29886761/paeonol-attenuates-isoflurane-anaesthesia-induced-hippocampal-neurotoxicity-via-modulation-of-jnk-erk-p38mapk-pathway-and-regulates-histone-acetylation-in-neonatal-rat
#2
Haiyan Jin, Minyan Wang, Jiangmei Wang, Hongmin Cao, Wanting Niu, Lizhong Du
OBJECTIVE: Volatile anaesthetic such as isoflurane causes widespread neurodegeneration in the developing animal brains and also induces cognitive impairments. Paeonol, is a plant-derived phenolic compound possessing numerous bioactive properties. The study investigates the neuroprotective effects of paeonol against isoflurane-induced neurodegeneration and cognitive disturbances in neonatal rats. METHODS: Paeonol (50, 100 and 150 mg/kg body weight/ day) was given orally to separate groups of neonatal rats from postnatal day 3 (P3) to P21 and were exposed to isoflurane (0...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29848652/flexible-memory-controls-sperm-competition-responses-in-male-drosophila-melanogaster
#3
J Rouse, K Watkinson, A Bretman
Males of many species use social cues to predict sperm competition (SC) and tailor their reproductive strategies, such as ejaculate or behavioural investment, accordingly. While these plastic strategies are widespread, the underlying mechanisms remain largely unknown. Plastic behaviour requires individuals to learn and memorize cues associated with environmental change before using this experience to modify behaviour. Drosophila melanogaster respond to an increase in SC threat by extending mating duration after exposure to a rival male...
May 30, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29649504/tau-pathology-and-neurochemical-changes-associated-with-memory-dysfunction-in-an-optimised-murine-model-of-global-cerebral-ischaemia-a-potential-model-for-vascular-dementia
#4
Sabah Khan, Nadira Y Yuldasheva, Trevor F C Batten, Alasdair R Pickles, Katherine A B Kellett, Sikha Saha
Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to lack of clinically relevant models that are highly reproducible. Here, we have optimised a murine model of global cerebral ischaemia with multiple markers to determine brain pathology, neurochemistry and correlated memory deficits in these animals. Cerebral ischaemia in mice was induced by bilateral common carotid artery occlusion...
April 9, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29621842/repetitive-transcranial-magnetic-stimulation-in-the-treatment-of-depression
#5
Saxby Pridmore, William Pridmore
BACKGROUND: Transcranial magnetic stimulation (TMS)is a treatment for major depressive disorder that is otherwise resistant to treatment. Although world-leading research in TMS has been conducted in Australia, where it has had some availability for two decades, there is limited familiarity with the treatment in the general medical community. Availability, however, is increasing. OBJECTIVE: The aim of this article is to inform general practitioners of some scientific and practical aspects of TMS treatment...
March 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29576116/persistent-alteration-in-behavioural-reactivity-to-a-mild-social-stressor-in-rhesus-monkeys-repeatedly-exposed-to-sevoflurane-in-infancy
#6
J Raper, J C De Biasio, K L Murphy, M C Alvarado, M G Baxter
BACKGROUND: Socio-emotional development is the expression and management of emotions, which in non-human primates can be examined using responses toward increasing levels of threat. Damage to the limbic system alters socio-emotional development in primates. Thus, neuronal and glial cell loss caused by exposure to general anaesthesia early in infancy might also impact socio-emotional development. We recently reported that repeated sevoflurane exposure in the first month of life alters emotional behaviours at 6 months of age and impairs visual recognition memory after the first year of life in rhesus monkeys...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29546387/hospitalisation-and-surgery-are-there-hidden-cognitive-consequences-evidence-from-the-irish-longitudinal-study-on-ageing-tilda
#7
Helen O' Brien, Neil O' Leary, Siobhan Scarlett, Celia O' Hare, Rose Anne Kenny
Background: the dramatic shift in the global population demographic has led to increasing numbers of older people undergoing hospitalisation and surgical procedures. Objectives: to determine whether hospitalisation or hospitalisation with surgery under general anaesthesia is associated with poorer cognitive performance in adults over the age of 50. Methods: cognitive function in the domains of global cognition, memory and executive function was assessed in 8,023 individuals at waves 1 and 2 of The Irish Longitudinal Study on Ageing (TILDA), 2 years apart...
May 1, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29468634/cognitive-decline-in-the-middle-aged-after-surgery-and-anaesthesia-results-from-the-wisconsin-registry-for-alzheimer-s-prevention-cohort
#8
L C Bratzke, R L Koscik, K J Schenning, L R Clark, M A Sager, S C Johnson, B P Hermann, K J Hogan
Surgery and anaesthesia might affect cognition in middle-aged people without existing cognitive dysfunction. We measured memory and executive function in 964 participants, mean age 54 years, and again four years later, by when 312 participants had had surgery and 652 participants had not. Surgery between tests was associated with a decline in immediate memory by one point (out of a maximum of 30), p = 0.013: memory became abnormal in 77 out of 670 participants with initially normal memory, 21 out of 114 (18%) of whom had had surgery compared with 56 out of 556 (10%) of those who had not, p = 0...
May 2018: Anaesthesia
https://www.readbyqxmd.com/read/29461008/propofol-exposure-during-early-gestation-impairs-learning-and-memory-in-rat-offspring-by-inhibiting-the-acetylation-of-histone
#9
Jiamei Lin, Shengqiang Wang, Yunlin Feng, Weihong Zhao, Weilu Zhao, Foquan Luo, Namin Feng
Propofol is widely used in clinical practice, including non-obstetric surgery in pregnant women. Previously, we found that propofol anaesthesia in maternal rats during the third trimester (E18) caused learning and memory impairment to the offspring rats, but how about the exposure during early pregnancy and the underlying mechanisms? Histone acetylation plays an important role in synaptic plasticity. In this study, propofol was administered to the pregnant rats in the early pregnancy (E7). The learning and memory function of the offspring were tested by Morris water maze (MWM) test on post-natal day 30...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29452811/effects-on-adult-cognitive-function-after-neonatal-exposure-to-clinically-relevant-doses-of-ionising-radiation-and-ketamine-in-mice
#10
S Buratovic, B Stenerlöw, S Sundell-Bergman, A Fredriksson, H Viberg, T Gordh, P Eriksson
BACKGROUND: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model. METHODS: Male mice were exposed to a single dose of ketamine (7...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29260313/post-operative-cognitive-decline-pocd-after-gynaecologic-surgery-current-opinions-and-future-applications
#11
Cristina Zarbo, Michela Brivio, Agostino Brugnera, Chiara Malandrino, Gaetano Trezzi, Massimo Rabboni, Emi Bondi, Angelo Compare, Luigi Frigerio
OBJECTIVE: Postoperative cognitive decline (POCD) is known to occur quite frequently after a cardiac surgery, especially in older population. Few studies specifically focused on its incidence and characteristics in gynecological setting. METHODS: Current opinions and future applications of POCD studies in gynecological setting have been discussed. RESULT: There are still many questions and issues about POCD in gynecological setting that remain unanswered as well as numerous research fields that have not been still explored...
March 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29121298/human-neural-correlates-of-sevoflurane-induced-unconsciousness
#12
B J A Palanca, M S Avidan, G A Mashour
Sevoflurane, a volatile anaesthetic agent well-tolerated for inhalation induction, provides a useful opportunity to elucidate the processes whereby halogenated ethers disrupt consciousness and cognition. Multiple molecular targets of sevoflurane have been identified, complementing imaging and electrophysiologic markers for the mechanistically obscure progression from wakefulness to unconsciousness. Recent investigations have more precisely detailed scalp EEG activity during this transition, with practical clinical implications...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28969319/effects-of-propofol-and-surgery-on-neuropathology-and-cognition-in-the-3xtgad-alzheimer-transgenic-mouse-model
#13
F Mardini, J X Tang, J C Li, M J Arroliga, R G Eckenhoff, M F Eckenhoff
Background: Previous work suggests that anaesthesia and surgery amplify the pathology and cognitive impairment of animals made vulnerable via age or specific transgenes. We hypothesized that surgery under propofol anaesthesia, a widely used i.v. general anaesthetic, has minimal delayed cognitive and neuroinflammatory sequelae in a vulnerable mouse transgenic model. Methods: We conducted caecal ligation and excision surgery in cognitively presymptomatic (11-month-old) 3xTgAD mice under i...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28969308/inhibition-of-p75-neurotrophin-receptor-does-not-rescue-cognitive-impairment-in-adulthood-after-isoflurane-exposure-in-neonatal-mice
#14
J M Schilling, A Kassan, C Mandyam, M L Pearn, A Voong, G G Grogman, V B Risbrough, I R Niesman, H H Patel, P M Patel, B P Head
Background: Isoflurane is widely used for anaesthesia in humans. Isoflurane exposure of rodents prior to post-natal day 7 (PND7) leads to widespread neurodegeneration in laboratory animals. Previous data from our laboratory suggest an attenuation of apoptosis with the p75 neurotrophin receptor (p75NTR) inhibitor TAT-Pep5. We hypothesized that isoflurane toxicity leads to behavioural and cognitive abnormalities and can be rescued with pre-anaesthesia administration of TAT-Pep5. Methods: Neonatal mouse pups were pretreated with either TAT-Pep5 (25 μl, 10 μM i...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28752006/short-term-and-long-term-effects-of-dexamethasone-on-cognitive-dysfunction-induced-by-sevoflurane-in-adult-rats
#15
Tuğba Karaman, Serkan Karaman, Serkan Doğru, Hakan Tapar, Aynur Şahin, Mustafa Süren
OBJECTIVE: Postoperative cognitive dysfunction (POCD) is common after anaesthesia in elderly patients. However, it may appear in patients of all ages. The main pathogenesis of cognitive dysfunction remains unclear, although there is some evidence that brain inflammation may alter cognitive abilities. In the present study, we aim to evaluate short-term and long-term effects of dexamethasone on cognitive dysfunction induced by sevoflurane anaesthesia in adult rats. METHODS: Seven-month-old 30 male Wistar albino rats were randomised into three groups: sevoflurane group (exposure to sevoflurane), sevoflurane + dexamethasone group (exposure to sevoflurane and dexamethasone injection), and control group (exposure to 100% oxygen)...
June 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28673212/awareness-during-general-anaesthesia-in-the-first-4-000-incidents-reported-to-webairs
#16
K Leslie, M D Culwick, H Reynolds, J A Hannam, A F Merry
The aim of this study was to analyse the incidents related to awareness during general anaesthesia in the first 4,000 cases reported to webAIRS-an anaesthetic incident reporting system established in Australia and New Zealand in 2009. Included incidents were those in which the reporter selected "neurological" as the main category and "awareness/dreaming/nightmares" as a subcategory, those where the narrative report included the word "awareness" and those identified by the authors as possibly relevant to awareness...
July 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28575197/visual-recognition-memory-is-impaired-in-rhesus-monkeys-repeatedly-exposed-to-sevoflurane-in-infancy
#17
M C Alvarado, K L Murphy, M G Baxter
Background: Experimental studies in animals have shown that exposure to general anaesthesia in infancy can cause loss of cells in the central nervous system and long-term impairments in neurocognitive function. Some human epidemiological studies have shown increased risk of learning disability after repeated anaesthesia exposure in early childhood. Thus, we investigated in a highly translational rhesus monkey model, whether repeated exposure in infancy to the inhalation anaesthetic sevoflurane is associated with impaired visual recognition memory during the first two yr of life...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28558697/does-an-electronic-cognitive-aid-have-an-effect-on-the-management-of-severe-gynaecological-turp-syndrome-a-prospective-randomised-simulation-study
#18
RANDOMIZED CONTROLLED TRIAL
Michael St Pierre, Georg Breuer, Dieter Strembski, Christopher Schmitt, Bjoern Luetcke
BACKGROUND: Lack of familiarity with the content of current guidelines is a major factor associated with non-compliance by clinicians. It is conceivable that cognitive aids with regularly updated medical content can guide clinicians' task performance by evidence-based practices, even if they are unfamiliar with the actual guideline. Acute hyponatraemia as a consequence of TURP syndrome is a rare intraoperative event, and current practice guidelines have changed from slow correction to rapid correction of serum sodium levels...
May 30, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#19
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28349227/effects-of-bilateral-vestibular-deafferentation-in-rat-on-hippocampal-theta-response-to-somatosensory-stimulation-acetylcholine-release-and-cholinergic-neurons-in-the-pedunculopontine-tegmental-nucleus
#20
Phillip Aitken, Yiwen Zheng, Paul F Smith
Vestibular dysfunction has been shown to cause spatial memory impairment. Neurophysiological studies indicate that bilateral vestibular loss (BVL), in particular, is associated with an impairment of the response of hippocampal place cells and theta rhythm. However, the specific neural pathways through which vestibular information reaches the hippocampus are yet to be fully elucidated. The aim of the present study was to further investigate the hypothesised 'theta-generating pathway' from the brainstem vestibular nucleus to the hippocampus...
September 2017: Brain Structure & Function
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