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https://www.readbyqxmd.com/read/29889105/dexmedetomidine-prevents-excessive-%C3%AE-aminobutyric-acid-type-a-receptor-function-after-anesthesia
#1
Dian-Shi Wang, Kirusanthy Kaneshwaran, Gang Lei, Fariya Mostafa, Junhui Wang, Irene Lecker, Sinziana Avramescu, Yu-Feng Xie, Nathan K Chan, Alejandro Fernandez-Escobar, Junsung Woo, Darren Chan, Amy J Ramsey, Jeremy M Sivak, C Justin Lee, Robert P Bonin, Beverley A Orser
BACKGROUND: Postoperative delirium is associated with poor long-term outcomes and increased mortality. General anesthetic drugs may contribute to delirium because they increase cell-surface expression and function of α5 subunit-containing γ-aminobutyric acid type A receptors, an effect that persists long after the drugs have been eliminated. Dexmedetomidine, an α2 adrenergic receptor agonist, prevents delirium in patients and reduces cognitive deficits in animals. Thus, it was postulated that dexmedetomidine prevents excessive function of α5 γ-aminobutyric acid type A receptors...
June 8, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29870425/ect-a-new-look-at-an-old-friend
#2
Pavan Kumar Kadiyala, Lakshmi Deepthi Kadiyala
PURPOSE OF REVIEW: Electroconvulsive therapy (ECT) as a treatment option in psychiatry is advancing day by day. This review discusses new advancements in ECT with regards to anesthetic variables, stimulus, and response variables along with their impact on clinical outcomes. RECENT FINDINGS: Anesthetic variables influence clinical efficacy and patient tolerance of ECT. Although etomidate or a ketamine-propofol combination may be the first choice for many clinicians, the search for ideal induction agent continues...
June 4, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29867602/cognitive-and-neurophysiological-recovery-following-electroconvulsive-therapy-a-study-protocol
#3
Ben J A Palanca, Hannah R Maybrier, Angela M Mickle, Nuri B Farber, R Edward Hogan, Emma R Trammel, J Wylie Spencer, Donald D Bohnenkamp, Troy S Wildes, ShiNung Ching, Eric Lenze, Mathias Basner, Max B Kelz, Michael S Avidan
Electroconvulsive therapy (ECT) employs the elective induction of generalizes seizures as a potent treatment for severe psychiatric illness. As such, ECT provides an opportunity to rigorously study the recovery of consciousness, reconstitution of cognition, and electroencephalographic (EEG) activity following seizures. Fifteen patients with major depressive disorder refractory to pharmacologic therapy will be enrolled (Clinicaltrials.gov, NCT02761330). Adequate seizure duration will be confirmed following right unilateral ECT under etomidate anesthesia...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29802440/-patient-endangerment-due-to-device-diversity-discussion-of-a-risk-factor-based-on-the-results-of-two-surveys-of-german-hospitals
#4
K Lange, A Brinker, M Nowak, C Zöllner, W Lauer
BACKGROUND: The Federal Institute for Drugs and Medical Devices (BfArM) was notified of an event in which it was not possible to sufficiently ventilate a patient suffering a severe asthma attack. It turned out that the ventilation pressures used by the device for pressure-controlled ventilation were below the values set by the user, which the user was not aware of. The ventilation pressures chosen by the user exceeded the preset alarm limits of the ventilator. This pressure and alarm management significantly differed from that of other ventilators used in the hospital...
May 25, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29793130/anxiety-memories-and-coping-in-patients-undergoing-intracranial-tumor-surgery
#5
Tom J van Ark, Markus Klimek, Peter de Smalen, Arnaud J P E Vincent, Robert Jan Stolker
OBJECTIVES: The diagnosis and the surgical removal of a brain tumor can have serious impact on the quality of life of a patient. The question rises, whether having more or just less memories of the procedure is better for coping with such an event. Furthermore, for preoperative information of future patients it is important to know how patients process their emotions and memories. The primary objective of this study was to investigate the link between preoperative anxiety, the perioperative experience and the quantity and quality of postoperative memories in patients who underwent intracranial tumor surgery...
July 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29781223/delayed-injury-of-hippocampal-interneurons-after-neonatal-hypoxia-ischemia-and-therapeutic-hypothermia-in-a-murine-model
#6
Raul Chavez-Valdez, Paul Emerson, Janasha Goffigan-Holmes, Alfredo Kirkwood, Lee J Martin, Frances J Northington
Delayed hippocampal injury and memory impairments follow neonatal hypoxia-ischemia (HI) despite the use of therapeutic hypothermia (TH). Death of hippocampal pyramidal cells occurs acutely after HI, but characterization of delayed cell death and injury of interneurons (INs) is unknown. We hypothesize that injury of INs after HI is: i) asynchronous to that of pyramidal cells, ii) independent of injury severity, and iii) unresponsive to TH. HI was induced in C57BL6 mice at p10 with unilateral right carotid ligation and 45 min of hypoxia (FiO2 =0...
May 21, 2018: Hippocampus
https://www.readbyqxmd.com/read/29776428/evidence-of-the-impact-of-systemic-inflammation-on-neuroinflammation-from-a-non-bacterial-endotoxin-animal-model
#7
Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang
BACKGROUND: Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without any pathogen, to characterize these changes and their responses to anti-inflammatory treatment in the intermediate term. METHODS: In a two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected to sevoflurane anesthesia alone or to a laparotomy...
May 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29761010/central-cholinergic-system-mediates-working-memory-deficit-induced-by-anesthesia-surgery-in-adult-mice
#8
Xiao Zhang, Xuliang Jiang, Lili Huang, Weitian Tian, Xuemei Chen, Xiyao Gu, Weifeng Yu, Jie Tian, Diansan Su
Background: Postoperative cognitive dysfunction (POCD) is consistently associated with increased morbidity and mortality, which has become a major concern of patients and caregivers. Although POCD occurs mainly in aged patients, it happens at any age. Previous studies demonstrated that anesthesia/surgery had no effects on reference memory of adult mice. However, whether it impairs working memory remains unclear. Working memory deficit would result in many deficits of executive function...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29755332/neurofeedback-and-the-neural-representation-of-self-lessons-from-awake-state-and-sleep
#9
Andreas A Ioannides
Neurofeedback has been around for half a century, but despite some promising results it is not yet widely appreciated. Recently, some of the concerns about neurofeedback have been addressed with functional magnetic resonance imaging and magnetoencephalography adding their contributions to the long history of neurofeedback with electroencephalography. Attempts to address other concerns related to methodological issues with new experiments and meta-analysis of earlier studies, have opened up new questions about its efficacy...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29752843/propofol-anesthesia-exposure-and-nonaversive-memory-retrieval-and-the-expression-of-molecules-involved-in-memory-process-in-the-dorsal-hippocampus-in-peripubertal-rats
#10
Željko Pavković, Desanka Milanović, Sabera Ruždijić, Selma Kanazir, Vesna Pešić
BACKGROUND: The effects of anesthetic drugs on postoperative cognitive function in children are not well defined and have not been experimentally addressed. AIMS: The present study aimed to examine the influence of propofol anesthesia exposure on nonaversive hippocampus-dependent learning and biochemical changes involved in memory process in the dorsal hippocampus, in peripubertal rats as the rodent model of periadolescence. METHODS: The intersession spatial habituation and the novel object recognition tasks were used to assess spatial and nonspatial, nonaversive hippocampus-dependent learning...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29747622/postoperative-dental-morbidity-in-children-following-dental-treatment-under-general-anesthesia
#11
Yu-Hsuan Hu, Aileen Tsai, Li-Wei Ou-Yang, Li-Chuan Chuang, Pei-Ching Chang
BACKGROUND: General anesthesia has been widely used in pediatric dentistry in recent years. However, there remain concerns about potential postoperative dental morbidity. The goal of this study was to identify the frequency of postoperative dental morbidity and factors associated with such morbidity in children. METHODS: From March 2012 to February 2013, physically and mentally healthy children receiving dental treatment under general anesthesia at the Department of Pediatric Dentistry of the Chang Gung Memorial Hospital in Taiwan were recruited...
May 10, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29731813/sevoflurane-induced-memory-impairment-in-the-postnatal-developing-mouse-brain
#12
Zhijun Lu, Jihui Sun, Yichun Xin, Ken Chen, Wen Ding, Yujia Wang
The aim of the present study was to confirm that sevoflurane induces memory impairment in the postnatal developing mouse brain and determine its mechanism of action. C57BL/6 mice 7 days old were randomly assigned into a 2.6% sevoflurane (n=68), a 1.3% sevoflurane (n=68) and a control (n=38) group. Blood gas analysis was performed to evaluate hypoxia and respiratory depression during anesthesia in 78 mice. Measurements for expression of caspase-3 by immunohistochemistry, cleavage of poly adenosine diphosphate-ribose polymerase (PARP) by western blotting, as well as levels of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor type 2 (Ntrk2), pro-BDNF, p75 neurotrophin receptor (p75NTR) and protein kinase B (PKB/Akt) by enzyme-linked immunosorbent assay were performed in the hippocampus of 12 mice from each group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29725829/involvement-of-acute-neuroinflammation-in-postoperative-delirium-like-cognitive-deficits-in-rats
#13
Takashi Kawano, Daiki Yamanaka, Bun Aoyama, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Atsushi Nishigaki, Hideki Iwata, Fabricio M Locatelli, Masataka Yokoyama
PURPOSE: The purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats. METHODS: Adult and aged rats were randomly assigned to one of three groups: control, isoflurane anesthesia alone, and isoflurane anesthesia with abdominal surgery. On either postoperative day 2 (early phase) or 7 (late phase), all rats were tested for trace and context fear memory retention after acquisition of trace fear conditioning...
May 3, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29694662/technique-of-localizing-the-central-sulcus-under-awaking-anesthesia-for-treatmeat-of-gliomas-in-or-near-motor-areas
#14
Wan Yi, Shujun Xu, Xingang Li, Xiangyu Ma
AIM: This study aimed to study the protective effect of intraoperative awakening and central sulcus location on motor function for patients with gliomas located in motor areas. METHODS: A total of 68 patients with gliomas in motor areas were intubated with a laryngeal mask and rapidly underwent craniotomy without scalp clips and awakening, followed by localization of the central sulcus by somatosensory evoked potential. To protect brain function, we resected the greatest degree of tumor as possible and then finished the close-skull under an awakened state or general anesthesia...
April 6, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#15
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion (BCCAo)-induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anaesthesia to induce VaD. The rats were subjected to Morris water maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby escape latency time, time spent in target quadrant and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#16
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
August 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29614089/hippocampal-protein-kinase-d1-is-necessary-for-dhpg-induced-learning-and-memory-impairments-in-rats
#17
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
BACKGROUND: Understanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons by application of (S)-3,5-Dihydroxyphenylglycine (DHPG) causes the regulated internalization of N-methyl-D-aspartate receptors (NMDARs), which subsequently activates protein kinase D1 (PKD1). Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs...
2018: PloS One
https://www.readbyqxmd.com/read/29610572/effectiveness-of-bilateral-superficial-cervical-plexus-block-as-part-of-postoperative-analgesia-for-patients-undergoing-thyroidectomy-in-empress-zewditu-memorial-hospital-addis-ababa-ethiopia
#18
Zemedu Aweke, Wosenyeleh A Sahile, Sileshi Abiy, Nugusu Ayalew, Adugna A Kassa
Introduction: The pain after thyroid surgery is considered of moderate intensity and short duration. Most trials showed significant reduction in pain intensity and severity of pain in patients for whom bilateral superficial cervical plexus block (BSCPB) was done. Objective: To assess the postoperative analgesic effect of BSCPB for thyroid surgery. Methods: Sixty six euthyroid patients were recruited and assigned to two groups (33 patients each)...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29599834/improvement-of-postoperative-cognitive-dysfunction-and-attention-network-function-of-patients-with-ischemic-cerebrovascular-disease-via-dexmedetomidine
#19
Jingchao Zhang, Guoliang Wang, Fangxiang Zhang, Qian Zhao
The protective effect of dexmedetomidine on cognitive dysfunction and decreased attention network function of patients with ischemic cerebrovascular disease after stenting was investigated. Fifty-eight patients with ischemic cerebrovascular disease undergoing stenting in Guizhou Provincial People's Hospital were selected and randomly divided into control group (n=29) and dexmedetomidine group (n=29). The dexmedetomidine group was treated with dexmedetomidine before induced anesthesia, while the control group was given the same dose of normal saline; and the normal volunteers of the same age were selected as the normal group (n=29)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29578002/inhibition-of-microrna-34a-protects-against-propofol-anesthesia-induced-neurotoxicity-and-cognitive-dysfunction-via-the-mapk-erk-signaling-pathway
#20
Guang Feng Li, Zhi Bing Li, Su Jing Zhuang, Guang Cai Li
AIM: To investigate the protective effect of microRNA-34a (miR-34a) on propofol-induced neurotoxicity and cognitive dysfunction. METHODS: After SH-SY5Y cells were treated with propofol to induce neurotoxicity, microRNA-34a mimics and inhibitors were transfected into the cells. The expression of apoptosis-related genes and the proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Sprague-Dawley (SD) rats received intraperitoneal injections of propofol, and were treated with microRNA-34a mimics and lentivirus-mediated microRNA-34a inhibitors...
May 14, 2018: Neuroscience Letters
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