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memory and anesthesia

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https://www.readbyqxmd.com/read/29614089/hippocampal-protein-kinase-d1-is-necessary-for-dhpg-induced-learning-and-memory-impairments-in-rats
#1
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
BACKGROUND: Understanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons by application of (S)-3,5-Dihydroxyphenylglycine (DHPG) causes the regulated internalization of N-methyl-D-aspartate receptors (NMDARs), which subsequently activates protein kinase D1 (PKD1). Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs...
2018: PloS One
https://www.readbyqxmd.com/read/29610572/effectiveness-of-bilateral-superficial-cervical-plexus-block-as-part-of-postoperative-analgesia-for-patients-undergoing-thyroidectomy-in-empress-zewditu-memorial-hospital-addis-ababa-ethiopia
#2
Zemedu Aweke, Wosenyeleh A Sahile, Sileshi Abiy, Nugusu Ayalew, Adugna A Kassa
Introduction: The pain after thyroid surgery is considered of moderate intensity and short duration. Most trials showed significant reduction in pain intensity and severity of pain in patients for whom bilateral superficial cervical plexus block (BSCPB) was done. Objective: To assess the postoperative analgesic effect of BSCPB for thyroid surgery. Methods: Sixty six euthyroid patients were recruited and assigned to two groups (33 patients each)...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29599834/improvement-of-postoperative-cognitive-dysfunction-and-attention-network-function-of-patients-with-ischemic-cerebrovascular-disease-via-dexmedetomidine
#3
Jingchao Zhang, Guoliang Wang, Fangxiang Zhang, Qian Zhao
The protective effect of dexmedetomidine on cognitive dysfunction and decreased attention network function of patients with ischemic cerebrovascular disease after stenting was investigated. Fifty-eight patients with ischemic cerebrovascular disease undergoing stenting in Guizhou Provincial People's Hospital were selected and randomly divided into control group (n=29) and dexmedetomidine group (n=29). The dexmedetomidine group was treated with dexmedetomidine before induced anesthesia, while the control group was given the same dose of normal saline; and the normal volunteers of the same age were selected as the normal group (n=29)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29578002/inhibition-of-microrna-34a-protects-against-propofol-anesthesia-induced-neurotoxicity-and-cognitive-dysfunction-via-the-mapk-erk-signaling-pathway
#4
Guang Feng Li, Su Jing Zhuang, Guang Cai Li
AIM: To investigate the protective effect of microRNA-34a (miR-34a) on propofol-induced neurotoxicity and cognitive dysfunction. METHODS: After SH-SY5Y cells were treated with propofol to induce neurotoxicity, microRNA-34a mimics and inhibitors were transfected into the cells. The expression of apoptosis-related genes and the proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Sprague-Dawley (SD) rats received intraperitoneal injections of propofol, and were treated with microRNA-34a mimics and lentivirus-mediated microRNA-34a inhibitors...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29545833/microrna-383-upregulation-protects-against-propofol-induced-hippocampal-neuron-apoptosis-and-cognitive-impairment
#5
Xinlei Wang, Guoyou Ding, Wei Lai, Shiwen Liu, Jun Shuai
Anesthesia-induced cognitive impairment is a recognized clinical phenomenon. The present study aimed to investigate the effect of microRNA-383 (miR-383) expression on propofol-induced learning and memory impairment. In total, 48 male Sprague-Dawley rats (weight, 250±10 g) were randomly divided into four groups (n=12 each): Control group, and three groups of rats that were anesthetized with propofol for 6 h and untreated (propofol model group), treated with a constructed lentivirus vector expressing miR-383 mimics (mimic + propofol group), or treated with miR-383 scramble (scramble + propofol group)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29502203/amantadine-attenuates-sepsis-induced-cognitive-dysfunction-possibly-not-through-inhibiting-toll-like-receptor-2
#6
Wei Xing, Pinjie Huang, Yang Lu, Weian Zeng, Zhiyi Zuo
Amantadine has been shown to reduce anesthesia and surgery-induced neuroinflammation and cognitive dysfunction. It is known that sepsis can impair brain function. We determined whether amantadine-attenuated sepsis-induced neuroinflammation and dysfunction of learning and memory and whether toll-like receptors (TLRs) play a role in the effects. Six- to eight-week-old mice were subjected to cecal ligation and puncture (CLP). Amantadine at 30 mg/kg/day was injected intraperitoneally for 3 days. CU-CPT22, a TLR1/TLR2 inhibitor, at 3 mg/kg/day was injected intraperitoneally for 2 days...
March 3, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29486082/use-of-a-novel-memory-aid-to-educate-perioperative-team-members-on-proper-patient-positioning-technique
#7
Kaitlen O Woodfin, Corey Johnson, Renee Parker, Caroline Mikach, Molly Johnson, Susan P McMullan
Interdisciplinary collaboration is key to safe surgical positioning. Although the surgical procedure dictates the patient's position, surgeons, anesthesia care providers, intraoperative nurses, and ancillary staff members must work together to achieve the goal of safe positioning. Correct patient positioning includes the provision of adequate access to the surgical site for the surgeon and surgical assistants. Surgical positions may put the patient at risk of injury. Understanding human anatomy, including the nerves commonly affected by each surgical position, can help the surgical team prevent accidental and irreversible patient injury...
March 2018: AORN Journal
https://www.readbyqxmd.com/read/29459369/the-nucleus-reuniens-controls-long-range-hippocampo-prefrontal-gamma-synchronization-during-slow-oscillations
#8
Maëva Ferraris, Antoine Ghestem, Ana F Vicente, Lauriane Nallet-Khosrofian, Christophe Bernard, Pascale P Quilichini
Gamma oscillations are involved in long-range coupling of distant regions which support various cognitive operations. Here we show in adult male rats that synchronized bursts of gamma oscillations bind the hippocampus (HPC) and prefrontal cortex (mPFC) during slow oscillations and slow wave sleep, a brain state that is central for consolidation of memory traces. These gamma bursts entrained the firing of the local HPC and mPFC neuronal populations. Neurons of the nucleus reuniens (NR), which is a structural and functional hub between HPC and mPFC, demonstrated a specific increase in their firing prior to gamma burst onset, suggesting their involvement in HPC-mPFC binding...
February 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29452136/neuroprotective-effects-of-valproic-acid-on-brain-ischemia-are-related-to-its-hdac-and-gsk3-inhibitions
#9
Monalisa Ribeiro Silva, Alyne Oliveira Correia, Gabriel Cabral Alencar Dos Santos, Lucas Leimig Telles Parente, Keicy Parente de Siqueira, Danielly Gonçalves Sombra Lima, Jonathan Almeida Moura, Ana Elisa da Silva Ribeiro, Roberta Oliveira Costa, Daniel Luna Lucetti, Elaine Cristina Pereira Lucetti, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders. The objective was to evaluate the neuroprotective effects of VA on a brain ischemia model. The groups of male Wistar rats were: SO (sham-operated), ischemic and ischemic treated with VA (25, 50 and 100 mg/kg, p.o.). After anesthesia with ketamine and xilazine, the animals were subjected to clamping of carotid arteries (30 min) and reperfusion. Except for the carotid clamping, the SO group was submitted to the same procedure...
February 13, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29439328/impact-of-total-knee-arthroplasty-with-general-anesthesia-on-brain-networks-cognitive-efficiency-and-ventricular-volume-predict-functional-connectivity-decline-in-older-adults
#10
Haiqing Huang, Jared Tanner, Hari Parvataneni, Mark Rice, Ann Horgas, Mingzhou Ding, Catherine Price
 Using resting state functional magnetic resonance imaging (RS-fMRI), we explored: 1) pre- to post-operative changes in functional connectivity in default mode, salience, and central executive networks after total knee arthroplasty (TKA) with general anesthesia, and 2) the contribution of cognitive/brain reserve metrics these resting state functional declines. Individuals age 60 and older electing unilateral total knee arthroplasty (TKA; n = 48) and non-surgery peers with osteoarthritis (n = 45) completed baseline cognitive testing and baseline and post-surgery (post-baseline, 48-h post-surgery) brain MRI...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29410165/mid-gestational-sevoflurane-exposure-inhibits-fetal-neural-stem-cell-proliferation-and-impairs-postnatal-learning-and-memory-function-in-a-dose-dependent-manner
#11
Yuan Wang, Shaowei Yin, Hang Xue, Yating Yang, Nan Zhang, Ping Zhao
Advancements in fetal intervention procedures have led to increases in the number of pregnant women undergoing general anesthesia during the second trimester-a period characterized by extensive proliferation of fetal neural stem cells (NSCs). However, few studies have investigated the effects of mid-gestational sevoflurane exposure on fetal NSC proliferation or postnatal learning and memory function. In the present study, pregnant rats were randomly assigned to a control group (C group), a low sevoflurane concentration group (2%; L group), a high sevoflurane concentration group (3...
January 31, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29345054/isoflurane-anesthesia-in-aged-mice-and-effects-of-a1-adenosine-receptors-on-cognitive-impairment
#12
Chun-Long Zuo, Chun-Man Wang, Jin Liu, Ting Shen, Jiang-Ping Zhou, Xin-Rui Hao, Yi-Zhao Pan, Hua-Cheng Liu, Qing-Quan Lian, Han Lin
AIMS: Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed to the POCD occurrence through A1 adenosine receptor (A1AR) in aged mice. METHODS: We assessed cognitive function of mice with Morris water maze (MWM) and then measured expression level of two AD biomarkers (P-tau and Aβ) and a subtype of the NMDA receptor (NR2B) in aged wild-type (WT) and homozygous A1 adenosine receptor (A1AR) knockout (KO) mice at baseline and after they were exposed to isoflurane (1...
January 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29344658/microrna-188-3p-is-involved-in-sevoflurane-anesthesia-induced-neuroapoptosis-by-targeting-mdm2
#13
Lei Wang, Mengliang Zheng, Shuishui Wu, Zhiqiang Niu
Sevoflurane is a commonly used inhalation anesthetic. Sevoflurane-induced neuroapoptosis and cognitive impairments in animals are widely reported, however, the underlying molecular mechanisms remain largely unknown. The results of the present study demonstrated that sevoflurane anesthesia induced spatial memory impairments in rats, as determined by the Morris water maze test. Mechanistically, the current study demonstrated that sevoflurane administration significantly enhanced the expression of microRNA (miR)‑188‑3p...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29335389/checklist-in-colorectal-surgery-proposal-of-experts-of-the-polish-club-of-coloproctology-and-national-consultant-in-general-surgery
#14
Tomasz Banasiewicz, Łukasz Krokowicz, Piotr Richter, Adam Dziki, Piotr Krokowicz, Zbigniew Lorenc, Marek Szczepkowski, Michał Drews, Grzegorz Wallner
A checklist is a collection of information that helps reduce the risk of failure due to limitations in human memory and attention. In surgery, the first Surgical Safety Checklist (SSC), created under the supervision of WHO (World Health Organization), was established in 2007 and covers three stages related to the patient's stay in the operating theater and operation: 1. Prior to initiation (induction) of anesthesia; 2. before cutting the skin; 3. before the patient leaves the operating room Colorectal surgery is particularly at high risk for complications and relatively high mortality...
December 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29325538/influence-of-isoflurane-exposure-in-pregnant-rats-on-the-learning-and-memory-of-offsprings
#15
Wei Huang, Yunxia Dong, Guangyi Zhao, Yuan Wang, Jingjing Jiang, Ping Zhao
BACKGROUND: About 2% of pregnant women receive non-obstetric surgery under general anesthesia each year. During pregnancy, general anesthetics may affect brain development of the fetus. This study aimed to investigate safe dosage range of isoflurane. METHODS: Forty-eight SpragueDawley (SD) pregnant rats were randomly divided into 3 groups and inhaled 1.3% isoflurane (the Iso1 group), 2.0% isoflurane (the Iso2 group) and 50% O2 alone (the control group) for 3 h, respectively...
January 11, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29303789/sevoflurane-blocks-the-induction-of-long-term-potentiation-when-present-during-but-not-when-present-only-before-the-high-frequency-stimulation
#16
Jinyang Liu, Lie Yang, Daisy Lin, James E Cottrell, Ira S Kass
BACKGROUND: This study tests the hypothesis that sevoflurane blocks long-term potentiation only if it is present during the high-frequency stimulation that induces long-term potentiation. METHODS: Long-term potentiation, an electrophysiologic correlate of memory, was induced by high-frequency stimulation and measured as a persistent increase in the field excitatory postsynaptic potential slope in the CA1 region. RESULTS: Long-term potentiation was induced in the no sevoflurane group (171 ± 58% vs...
March 2018: Anesthesiology
https://www.readbyqxmd.com/read/29288070/neonatal-erythropoietin-mitigates-impaired-gait-social-interaction-and-diffusion-tensor-imaging-abnormalities-in-a-rat-model-of-prenatal-brain-injury
#17
Shenandoah Robinson, Christopher J Corbett, Jesse L Winer, Lindsay A S Chan, Jessie R Maxwell, Christopher V Anstine, Tracylyn R Yellowhair, Nicholas A Andrews, Yirong Yang, Laurel O Sillerud, Lauren L Jantzie
Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these children. Moreover, the mechanisms of perinatal brain injury that result in functional deficits and imaging abnormalities in the mature brain are poorly defined, limiting the potential to target interventions to those who may benefit most...
April 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29279051/early-gestational-exposure-to-isoflurane-causes-persistent-cell-loss-in-the-dentate-gyrus-of-adult-male-rats
#18
Arvind Palanisamy, Gregory Crosby, Deborah J Culley
BACKGROUND: Our previous research showed that 4 h of maternal anesthesia with isoflurane during early gestation in pregnant rats leads to a deficit in spatial memory of adult male offspring. Because spatial memory is predominantly a hippocampally-mediated task, we asked the question if early gestational exposure to isoflurane affects development of the hippocampus in the offspring. FINDINGS: Previously behaviorally characterized adult male rats that were exposed to isoflurane during second trimester were sacrificed at 4 months of age (N = 10 and 13, control and isoflurane groups, respectively) for quantitative histology of hippocampal subregions...
December 26, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29259553/indication-of-cognitive-change-and-associated-risk-factor-after-thoracic-surgery-in-the-elderly-a-pilot-study
#19
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects ( n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29225748/multiple-exposures-of-sevoflurane-during-pregnancy-induces-memory-impairment-in-young-female-offspring-mice
#20
Woosuk Chung, Seunghwan Yoon, Yong Sup Shin
Background: Earlier studies have reported conflicting results regarding long-term behavioral consequences after anesthesia during the fetal period. Previous studies also suggest several factors that may explain such conflicting data. Thus, we examined the influence of age and sex on long-term behavioral consequences after multiple sevoflurane exposures during the fetal period. Methods: C57BL/6J pregnant mice received oxygen with or without sevoflurane for 2 hours at gestational day (GD) 14-16...
December 2017: Korean Journal of Anesthesiology
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