Jeffrey W Priest, James P Kwon, Joel M Montgomery, Caryn Bern, Delynn M Moss, Amanda R Freeman, Cara C Jones, Michael J Arrowood, Kimberly Y Won, Patrick J Lammie, Robert H Gilman, Jan R Mead
Cryptosporidium infection is commonly observed among children and immunocompromised individuals in developing countries, but large-scale outbreaks of disease among adults have not been reported. In contrast, outbreaks of cryptosporidiosis in the United States and Canada are increasingly common among patients of all ages. Thus, it seems likely that residents of regions where Cryptosporidium is highly endemic acquire some level of immunity, while residents of the developed world do not. A new immunodominant Cryptosporidium parvum antigen in the 15- to 17-kDa size range was identified as the Cryptosporidium parvum 60S acidic ribosomal protein P2 (CpP2)...
June 2010: Clinical and Vaccine Immunology: CVI