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radiotherapy for carcinoma prostate

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https://www.readbyqxmd.com/read/28424830/-when-is-a-nonsurgical-approach-possible-for-metastatic-primary-tumors-and-lymph-node-metastases-of-the-urinary-bladder-and-prostate
#1
R Fietkau
For metastatic carcinomas of the urinary bladder and prostate, systemic therapy is of primary importance. Due to technological advances in radiation oncology such as stereotactic radiotherapy, intensity-modulated radiotherapy, interstitial radiotherapy, and the combination of radiotherapy and chemotherapy, pelvic irradiation can nowadays be carried out effectively and without the risk of major side effects. New data from other tumor entities and retrospective analyses suggest that the use of these technologies can lead to a clinical benefit in terms of improvement in quality of life, local control, and overall survival...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28403777/potential-molecular-targets-of-ampelopsin-in-prevention-and-treatment-of-cancers
#2
Xianjuan Kou, Jingjing Fan, Ning Chen
Cancers have increasing threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28314541/risk-of-subsequent-primary-kidney-cancer-after-another-malignancy-a-population-based-study
#3
Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of kidney cancer as a second malignant neoplasm following the diagnosis of other common malignancies are rare. This clinical scenario has been evaluated within the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: The SEER-9 database (1973-2013) was queried using the SEER*Stat program to determine the standardized incidence ratios (SIRs) of kidney cancer development following each one of 10 common invasive malignancies (colorectal, breast, prostate, lung, thyroid, corpus uteri, urinary bladder, kidney/renal pelvis, cutaneous melanoma, and non-Hodgkin lymphoma)...
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28299284/integral-dose-based-inverse-optimization-may-reduce-side-effects-in-radiotherapy-of-prostate-carcinoma
#4
Ivaylo B Mihaylov
PURPOSE: The purpose of this work is to apply a novel inverse optimization approach, based on utilization of quantitative imaging information in the optimization function, to prostate carcinoma. MATERIALS AND METHODS: This new inverse optimization algorithm relies upon quantitative information derived from computed tomography (CT) imaging studies. The Hounsfield numbers of the CT voxels are converted to physical density, which in turn is used to calculate voxel mass and the corresponding integral dose, by summation over the product of dose and mass in each dose voxel...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28191295/small-cell-carcinoma-of-the-prostate-in-an-elderly-patient-a-case-report-and-review-of-the-literature
#5
Dale Alan Whitaker, Daniel H Miller, Niveditha Jagadesh, Gerald W Strong, Lauren Hintenlang, William B Schenk, Gregory A Broderick, Katherine S Tzou, Steven J Buskirk
Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation therapy, androgen deprivation therapy, or prostatectomy...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28116853/utility-of-68-ga-prostate-specific-membrane-antigen-positron-emission-tomography-in-diagnosis-and-response-assessment-of-recurrent-renal-cell-carcinoma
#6
Shankar Siva, Jason Callahan, David Pryor, Jarad Martin, Nathan Lawrentschuk, Michael S Hofman
INTRODUCTION: Prostate specific membrane antigen (PSMA) positron emission tomography (PET) is an emerging imaging modality in prostate cancer. However, (68) Ga-PSMA-PET may also have diagnostic utility in the setting of renal cell carcinoma (RCC). We investigate the differential role of (18) F-fluorodeoxyglucose (FDG) and PSMA-PET/CT scanning in patients with oligometastatic RCC. In particular, we focus on the utility of PSMA-PET for diagnostic evaluation of isolated or limited metastases planned for local surgery or radiation, as well as the potential utility of PSMA-PET for therapeutic response assessment in patients receiving stereotactic ablative body radiotherapy (SABR)...
January 24, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28047007/we-de-bra-03-construction-of-an-ultrasound-guidance-platform-for-image-guided-radiotherapy-with-the-intent-to-treat-transitional-cell-carcinoma
#7
J Sick, N Rancilio, C Fulkerson, P LaPetina, J Poulson, D Knapp, K Stantz
PURPOSE: Ultrasound (US) is a noninvasive, nonradiographic imaging technique with high spatial and temporal resolution that can be used for localizing soft-tissue structures and tumors in real-time during radiotherapy (inter- and intra-fraction). A detailed methodology integrating 3D-US within RT is presented. This method is easier to adopt into current treatment protocol than current US based systems and reduces user variability for image acquisition, thus eliminating transducer induced changes that limit CT planning system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046495/tu-h-campus-tep3-02-in-situ-dose-painting-using-gold-nanoparticles-released-from-cylindrically-shaped-fiducials-during-external-beam-radiation-therapy
#8
R Mueller, Y Hao, J Hesser, W Ngwa
PURPOSE: Recent studies have shown that the presence of Gold Nanoparticles (GNPs) in tumor tissue can lead to significant dose enhancement (DE) during External Beam Radiation Therapy (EBRT). In this in-silico study we investigate EBRT with in-situ dose painting using GNPs released from cylindrically shaped GNP-loaded fiducials. METHODS: Reported Biologically Target/Tumor Volumes (BTVs) for 12 prostate carcinoma patients were employed in this study. Distribution of the GNPs after burst release from the fiducial (1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27895678/prostate-brachytherapy-in-ghana-our-initial-experience
#9
James Edward Mensah, Joel Yarney, Verna Vanderpuye, Evans Akpakli, Samuel Tagoe, Evans Sasu
PURPOSE: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. MATERIAL AND METHODS: A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27822951/rectal-neuroendocrine-neoplasia-a-rare-tumour
#10
Marina de Benito Sanz, Javier Santos Fernández, Mª Henar Núñez Rodríguez
Colorectal neuroendocrine tumours are rare A 78 year old man with a history of hypertension, heart disease, pacemakers, prostate adenocarcinoma.On examination for rectal bleeding, a colonoscopy was performed and at 5 cm of the anal margin a 28 mm ulcerated neoformation was found.An echo-endoscopy revealed infiltration of the muscular layer with an area of loss in the cleavage plane loss and fraying of the perirectal fat infiltration suggestive of infiltration (T3). They no lymph nodes or metastasis were identified by CAT...
January 15, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27790587/immunohistochemical-expression-of-cyclin-b1-in-epithelial-hyperplasia-dysplasia-and-oral-squamous-cell-carcinomas-a-comparative-study
#11
Kochli Channappa Niranjan, Amsavardani Tayaar, G S Kumar, Rekha Krishnapillai, Kaveri Hallikeri, Santosh Hunasgi
INTRODUCTION: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis. AIM: Over expression of Cyclin B1, has been reported more recently in breast, colon, prostate, oral and esophageal carcinomas. Thus, the aim of the present study was to examine the expression of Cyclin B1 in hyperplasia, dysplasia and Oral Squamous Cell Carcinomas (OSCC)...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27720536/pathophysiology-and-contributing-factors-in-postprostatectomy-incontinence-a-review
#12
REVIEW
John Heesakkers, Fawzy Farag, Ricarda M Bauer, Jaspreet Sandhu, Dirk De Ridder, Arnulf Stenzl
CONTEXT: The incidence and awareness of postprostatectomy incontinence (PPI) has increased during the past few years, probably because of an increase in prostate cancer surgery. Many theories have been postulated to explain the pathophysiology of PPI. OBJECTIVE: The current review scrutinizes various pathophysiologic mechanisms underlying the occurrence of PPI. EVIDENCE ACQUISITION: A search was conducted on PubMed and EMBASE for publications on PPI...
June 2017: European Urology
https://www.readbyqxmd.com/read/27720534/systematic-review-on-the-fate-of-the-remnant-urothelium-after-radical-cystectomy
#13
REVIEW
Georgios Gakis, Peter C Black, Bernard H Bochner, Stephen A Boorjian, Arnulf Stenzl, George N Thalmann, Wassim Kassouf
CONTEXT: Urothelial carcinoma is considered a pan-urothelial disease. As such, the remnant urothelium in the upper urinary tract and urethra following radical cystectomy (RC) remains at risk for secondary urothelial tumors (SUTs). OBJECTIVE: To describe the incidence, diagnosis, treatment, and outcomes of patients with SUTs after RC. EVIDENCE ACQUISITION: A systematic search was conducted using PubMed database according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to identify studies between 1970 and 2016 reporting on malignant diseases of the urothelium after RC for bladder cancer...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27634567/squamous-cell-carcinoma-of-the-scrotum-after-brachytherapy-and-external-beam-radiotherapy-for-prostate-cancer-case-report-and-review-of-the-literature
#14
Zachary A Glaser, Matthew White, Elizabeth McKinley, Jeffrey S Glaser
No abstract text is available yet for this article.
August 20, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27553466/current-status-of-prostate-specific-membrane-antigen-targeting-in-nuclear-medicine-clinical-translation-of-chelator-containing-prostate-specific-membrane-antigen-ligands-into-diagnostics-and-therapy-for-prostate-cancer
#15
REVIEW
Clemens Kratochwil, Ali Afshar-Oromieh, Klaus Kopka, Uwe Haberkorn, Frederik L Giesel
The prostate-specific membrane antigen (PSMA) is expressed by approximately 90% of prostate carcinomas. The expression correlates with unfavorable prognostic factors, such as a high Gleason score, infiltrative growth, metastasis, and hormone-independence. The high specificity, especially in the undifferentiated stage, makes it an excellent target for diagnosis and therapy. Therefore, antibodies and small molecule inhibitors have been developed for imaging and therapy. In 2011 PSMA-11, a ligand that consists of the Glu-urea-motif and the chelator HBED-CC, which can be exclusively radiolabeled with (68)Ga for PET imaging, presented the clinical breakthrough for prostate cancer diagnostics...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27522247/prostate-cancer-outcomes-of-men-with-biopsy-gleason-score-6-and-7-without-cribriform-or-intraductal-carcinoma
#16
Charlotte F Kweldam, Intan P Kümmerlin, Daan Nieboer, Esther I Verhoef, Ewout W Steyerberg, Luca Incrocci, Chris H Bangma, Theodorus H van der Kwast, Monique J Roobol, Geert J van Leenders
AIM OF THE STUDY: Gleason score (GS) 3 + 4 = 7 prostate cancer patients with presence of cribriform or intraductal carcinoma (7(+)) have a worse disease-specific survival than those without. The aim of this study was to compare the clinicopathologic characteristics and patient outcomes of men with biopsy GS 3 + 4 = 7 without cribriform or intraductal carcinoma (7(-)) to those with GS 3 + 3 = 6. MATERIALS AND METHODS: We included all patients from the first screening round of the European Randomized Study of Screening for Prostate Cancer (1993-2000) with a revised GS ≤ 3 + 4 = 7 (n = 796) following the 2014 International Society of Urological Pathology criteria...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27461696/dosimetric-study-of-beam-angle-optimization-in-intensity-modulated-radiation-therapy-planning
#17
Arvind Kumar Shukla, Sanjeev Kumar, I S Sandhu, Arun S Oinam, Ranjit Singh, Rakesh Kapoor
PURPOSE: The quality of intensity-modulated radiotherapy (IMRT) highly depends on the choice of beam orientations and optimization algorithms used in the treatment planning. The present work reports dosimetric study of IMRT plans generated using preselected equiangular beam orientations (PSBO) and beam angle optimization (BAO) for the patients of prostate, head and neck, and esophagus carcinoma. MATERIALS AND METHODS: The computed tomography (CT) datasets of 30 patients treated with IMRT for prostate, head and neck, and esophagus carcinoma were selected...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27306777/hypofractionated-stereotactic-body-radiotherapy-in-low-and-intermediate-risk-prostate-carcinoma
#18
Hun Jung Kim, Jeong Hoon Phak, Woo Chul Kim
PURPOSE: Stereotactic body radiotherapy (SBRT) takes advantage of low α/β ratio of prostate cancer to deliver a large dose in few fractions. We examined clinical outcomes of SBRT using CyberKnife for the treatment of low- and intermediate-risk prostate cancer. MATERIALS AND METHODS: This study was based on a retrospective analysis of the 33 patients treated with SBRT using CyberKnife for localized prostate cancer (27.3% in low-risk and 72.7% in intermediate-risk)...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27299289/extrapulmonary-small-cell-carcinoma-of-the-seminal-vesicles-and-prostate-demonstrated-on-18f-fdg-positron-emission-tomography-computed-tomography
#19
Amir Iravani Tabrizipour, Lily Shen, Robert Mansberg, Bui Chuong
Extrapulmonary primary small cell carcinomas arising from the urogenital tract is infrequent. It can rarely arise from the prostate and even more rarely from the seminal vesicles. We present a 79-year-old male who was admitted due to acute renal failure with a history of radical radiotherapy for prostate adenocarcinoma 13 years ago. The prostate specific antigen level was not elevated. An abdominopelvic computed tomography (CT) scan showed markedly enlarged seminal vesicles causing bilateral ureteral obstruction and a mildly enlarged prostate...
February 5, 2016: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/27284452/gonadotropin-releasing-hormone-agonist-induced-pituitary-apoplexy
#20
Fergus Keane, Aoife M Egan, Patrick Navin, Francesca Brett, Michael C Dennedy
UNLABELLED: Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences. Drug-induced pituitary apoplexy is a rare but important consideration when evaluating patients with this presentation. We describe an unusual case of a patient with a known pituitary macroadenoma presenting with acute-onset third nerve palsy and headache secondary to tumour enlargement and apoplexy. This followed gonadotropin-releasing hormone (GNRH) agonist therapy used to treat metastatic prostate carcinoma...
2016: Endocrinology, Diabetes & Metabolism Case Reports
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