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https://www.readbyqxmd.com/read/28319567/treatment-of-biliary-stricture-after-live-donor-liver-transplantation-with-combined-metal-and-plastic-stent-%C3%A4-nsertion-a-feasibility-and-safety-study
#1
Erkan Parlak, Aydin Seref Koksal, Ahmet Tarik Eminler, Bilal Toka, Mustafa Ihsan Uslan
BACKGROUND: Fully covered-self expandable metal stents (Fc-SEMSs) have a challenging use in the treatment of anastomosis strictures (ASs) after live donor liver transplantation (LDLT) because they can occlude secondary branch biliary ducts when placed above the biliary bifurcation. In this study we evaluated the technical feasibility and safety of combining Fc-SEMSs with plastic stent(s) inserted to the secondary branch biliary ducts for the treatment of ASs after LDLT. METHODS: The study group included 22 patients (12 men, aged 51±11 years) with anastomotic biliary stricture after LDLT...
March 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28318929/biomarkers-in-diagnosis-and-therapy-of-oral-squamous-cell-carcinoma-a-review-of-the-literature
#2
Sebastian Blatt, Maximilian Krüger, Thomas Ziebart, Keyvan Sagheb, Eik Schiegnitz, Elisabeth Goetze, Bilal Al-Nawas, Andreas Max Pabst
Oral squamous cell carcinoma (OSCC) represents the sixth most common cancer, accounting for 2-4% of all malignancies worldwide. The overall survival rate of less than 60% remains generally poor, with prognosis heavily relying on the TNM staging system. Tumor size as well as the presence and extent of lymph node metastases are widely recognized as the most important predictors. However, the underlying mechanisms that lead to an aggressive phenotype are not yet fully understood. Therefore, possible biomarkers are much in need to predict prognosis, to help individualize therapy approaches, and to overcome possible resistance mechanisms...
February 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318501/sorafenib-use-for-recurrent-hepatocellular-cancer-after-resection-or-transplantation-observations-from-a-us-regional-analysis-of-the-gideon-registry
#3
Robert C G Martin, Elizabeth Bruenderman, Allen Cohn, Bilal Piperdi, Rebecca Miksad, Jean-Francois Geschwind, Alec Goldenberg, Arun Sanyal, Ellen Zigmont, Svetlana Babajanyan, Pamela Foreman, Parvez Mantry, Brendan McGuire, Pierre Gholam
Treatment of unresectable recurrent hepatocellular carcinoma (HCC) in patients who recur after resection or orthotopic liver transplantation (OLT) remains a clinical challenge. One option is sorafenib, although little is known about its safety and tolerance in this unique patient population; therefore, we analyzed patients who underwent prior surgical resection and/or OLT and were treated with sorafenib in US cohort of GIDEON registry. In US, 645 patients were enrolled; 553 for intent to treat and 563 for safety...
November 18, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28316005/purification-kinetic-and-thermodynamic-characteristics-of-an-exo-polygalacturonase-from-penicillium-notatum-with-industrial-perspective
#4
Faiza Amin, Haq Nawaz Bhatti, Muhammad Bilal, Muhammad Asgher
An extracellular exo-polygalacturonase (exo-PG) produced by Penicillium notatum was purified (3.07-folds) by ammonium sulfate fractionation, ion exchange, and gel filtration chromatography. Two distinct isoforms of the enzyme, namely exo-PGI and exo-PGII, were identified during column purification with molecular weights of 85 and 20 kDa, respectively, on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The enzyme displayed its optimum activity at pH 6.0 and 50 °C and was found to be stable in the slightly acidic pH (ranging from 4...
March 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28299761/comparison-of-percutaneous-nephrolithotomy-and-retrograde-intrarenal-surgery-in-treating-20-40-mm-renal-stones
#5
Gokhan Atis, Meftun Culpan, Eyup Sabri Pelit, Cengiz Canakci, Ismail Ulus, Bilal Gunaydin, Asif Yildirim, Turhan Caskurlu
PURPOSE: To compare the outcomes of percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) in treating renal stones between 20 and 40 mm in diameter. MATERIALS AND METHODS: 146 patients, who were treated with RIRS and 146 patients, who were treated with PCNL for renal stones between 20 and 40 mm in diameter were compared retrospectively using a matched-pair analysis. The operative and post-operative outcomes of both groups were analyzed retrospectively...
March 16, 2017: Urology Journal
https://www.readbyqxmd.com/read/28296984/implant-stability-and-bone-characteristics-in-free-fibula-flaps-used-for-jaw-reconstruction-a-prospective-cohort-study
#6
Vinay V Kumar, Ullash Kumar, Vijay Pillai, Vinotha Ponnusamy, Bilal Al-Nawas, Moni A Kuriakose
PURPOSE: The primary objective of this prospective cohort study was to evaluate primary and secondary implant stability values of implants placed into healed free fibula-reconstructed mandibles. The secondary objective was to investigate whether a correlation existed between primary implant stability and the quantity of cortical bone-implant contact and of cortical fibular bone in contact with the implants. MATERIALS AND METHODS: The study participants are patients enrolled in a registered trial (No...
March 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28293153/susceptibility-profile-of-methicillin-resistant-staphylococcus-aureus-to-linezolid-in-clinical-isolates
#7
Ali Shariq, Syed Bilal Tanvir, Atif Zaman, Salman Khan, Armeena Anis, Misha Aftab Khan, Sumaira Ahmed
OBJECTIVE: To determine the resistance and sensitivity pattern of methicillin-resistant Staphylococcus aureus (MRSA) isolates to linezolid (LZD) along with its prevalence in a tertiary care hospital of Karachi, Pakistan. MATERIALS AND METHODS: A cross-sectional study was carried out. This study lasted for about 1 year. Prevalence and sensitivity of LZD, vancomycin, and oxacillin was tested against isolates of MRSA. RESULTS: Out of total 369 specimens 165 were found to be MRSA making the prevalence in our study 44...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28291584/clinical-safety-and-activity-of-pembrolizumab-in-patients-with-malignant-pleural-mesothelioma-keynote-028-preliminary-results-from-a-non-randomised-open-label-phase-1b-trial
#8
Evan W Alley, Juanita Lopez, Armando Santoro, Anne Morosky, Sanatan Saraf, Bilal Piperdi, Emilie van Brummelen
BACKGROUND: Malignant pleural mesothelioma is a highly aggressive cancer with poor prognosis and few treatment options following progression on platinum-containing chemotherapy. We assessed the safety and efficacy of pembrolizumab (an anti-programmed cell death receptor 1 [PD-1] antibody) in advanced solid tumours expressing programmed cell death ligand 1 (PD-L1) and report here on the interim analysis of the malignant pleural mesothelioma cohort. METHODS: Previously treated patients with PD-L1-positive malignant pleural mesothelioma were enrolled from 13 centres in six countries...
March 10, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28286721/functional-outcome-after-decompressive-craniectomy-in-patients-with-dominant-or-non-dominant-malignant-middle-cerebral-infarcts
#9
Bilal Kamal Alam, Ahmed S Bukhari, Salman Assad, Pir Muhammad Siddique, Haider Ghazanfar, Muhammad Junaid Niaz, Maryam Kundi, Saima Shah, Maimoona Siddiqui
BACKGROUND:  The use of decompressive craniectomy (DC) has been studied in the setting of different conditions, including traumatic brain injury, subarachnoid hemorrhage, and malignant middle cerebral artery (MCA) infarction. The rationale of this study is to determine the functional outcome after DC in patients with malignant MCA infarcts. METHODS:  A longitudinal cohort study was performed based on patients diagnosed with malignant MCA territory infarction admitted to the Neurosurgery Department of a tertiary care hospital in Islamabad, Pakistan between July 2015 and November 2016...
January 26, 2017: Curēus
https://www.readbyqxmd.com/read/28282098/bayesian-network-as-a-support-tool-for-rapid-query-of-the-environmental-multimedia-distribution-of-nanomaterials
#10
Muhammad Bilal, Haven Liu, Rong Liu, Yoram Cohen
An approach is presented describing the development of a Bayesian network (BN) based tool for rapid assessment of the distribution of engineered nanomaterials (ENMs). The methodology was demonstrated via the construction of a BN model for estimating the exposure concentrations of nanomaterials (BN-nanoExpo) based on simulation data derived from a mechanistic multimedia compartmental fate and transport model. The results of simulations of the distribution of six ENMs in eight different regions were generated for a broad range of geographical and meteorological parameters as well as ENM release rates to the air, water and soil major compartments...
March 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28277062/platelet-function-testing-in-cardiac-surgery-a-comparative-study-of-electrical-impedance-aggregometry-and-thromboelastography
#11
Bilal H Kirmani, Robert Ian Johnson, Seema Agarwal
Point of care platelet function tests are increasingly used to assess drug-related platelet inhibition prior to cardiac surgery. Numerous devices are available including Thromboelastography (TEG(®) PlateletMapping™). The latest generation TEG(®) - the TEG(®) 6 - has recently been released incorporating a cartridge-based system with a PlateletMapping cartridge. In this study, the performance of the TEG(®) 6 PlateletMapping was compared to that of Multiple Electrode Aggregometry (MEA) performed with the Multiplate™...
February 21, 2017: Platelets
https://www.readbyqxmd.com/read/28272605/thermo-acoustofluidic-separation-of-vesicles-based-on-cholesterol-content
#12
Ata Dolatmoradi, Elnaz Mirtaheri, Bilal El-Zahab
Biomechanical properties of cells such as cellular stiffness have been increasingly considered as biomarkers for diseases. For instance, stiffness of cancer cells has been correlated to the malignant potential in certain cell lines. In cells, the cholesterol content plays a crucial role in determining stiffness. Changes in the cholesterol content in cellular membranes can be an indication of pathological disorders. Acoustophoresis as a separation and diagnostic tool is well positioned to help in the separation and diagnosis of cells taking advantage of its unique separation criteria of density and compressibility...
March 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28271018/hepatitis-c-serosorting-among-people-who-inject-drugs-in-rural-puerto-rico
#13
Ian Duncan, Ric Curtis, Juan Carlos Reyes, Roberto Abadie, Bilal Khan, Kirk Dombrowski
Due to the high cost of treatment, preventative measures to limit Hepatitis C (HCV) transmission among people who inject drugs (PWID) are encouraged by many public health officials. A key one of these is serosorting, where PWID select risk partners based on concordant HCV status. Research on the general U.S. population by Smith et al. (2013) found that knowledge of one's own HCV status facilitated serosorting behaviors among PWID, such that respondents with knowledge of their own status were more likely to ask potential partners about their status prior to sharing risk...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28271015/lactate-based-optical-screening-of-dengue-virus-infection-in-human-sera-using-raman-spectroscopy
#14
Muhammad Bilal, Rahat Ullah, Saranjam Khan, Hina Ali, Muhammad Saleem, Mushtaq Ahmed
This study presents the screening of dengue virus (DENV) infection in human blood sera based on lactate concentration using Raman spectroscopy. A total of 70 samples, 50 from confirmed DENV infected patients and 20 from healthy volunteers have been used in this study. Raman spectra of all these samples have been acquired in the spectral range from 600 cm(-1) to 1800 cm(-1) using a 532 nm laser as an excitation source. Spectra of all these samples have been analyzed for assessing the biochemical changes resulting from infection...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28269074/complex-network-analysis-of-resting-state-fmri-of-the-brain
#15
Abdul Rauf Anwar, Muhammad Yousaf Hashmy, Bilal Imran, Muhammad Hussnain Riaz, Sabtain Muhammad Muntazir Mehdi, Makii Muthalib, Stephane Perrey, Gunther Deuschl, Sergiu Groppa, Muthuraman Muthuraman
Due to the fact that the brain activity hardly ever diminishes in healthy individuals, analysis of resting state functionality of the brain seems pertinent. Various resting state networks are active inside the idle brain at any time. Based on various neuro-imaging studies, it is understood that various structurally distant regions of the brain could be functionally connected. Regions of the brain, that are functionally connected, during rest constitutes to the resting state network. In the present study, we employed the complex network measures to estimate the presence of community structures within a network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266608/human-amniotic-fluid-contaminants-alter-thyroid-hormone-signalling-and-early-brain-development-in-xenopus-embryos
#16
Jean-Baptiste Fini, Bilal B Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A Demeneix
Thyroid hormones are essential for normal brain development in vertebrates. In humans, abnormal maternal thyroid hormone levels during early pregnancy are associated with decreased offspring IQ and modified brain structure. As numerous environmental chemicals disrupt thyroid hormone signalling, we questioned whether exposure to ubiquitous chemicals affects thyroid hormone responses during early neurogenesis. We established a mixture of 15 common chemicals at concentrations reported in human amniotic fluid. An in vivo larval reporter (GFP) assay served to determine integrated thyroid hormone transcriptional responses...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260351/trifecta-of-complications-post-ercp-it-can-happen
#17
Thanh-Truc LE, Mohammad Bilal, Sreeram Parupudi
No abstract text is available yet for this article.
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28248822/mucous-membrane-pemphigoid-causing-central-airway-obstruction
#18
Bilal A Jalil, Yara G Abdou, Stephanie A Rosen, Tarek Dammad
Mucous membrane pemphigoid (MMP) is a rare variant of the skin disease pemphigoid, which predominantly involves the mucous membranes. This rare autoimmune disease that infrequently affects the respiratory tract is characterized by subepithelial blister formation that may result in scarring. Immunopathologic examination of mucous membranes reveals the deposition of immunoglobulins and complement within the subepithelial basement membrane. We describe a patient with undiagnosed MMP, with a near-fatal presentation of central airway obstruction causing acute respiratory distress...
February 28, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28245550/ar-signaling-in-breast-cancer
#19
REVIEW
Bilal Rahim, Ruth O'Regan
Androgen receptor (AR, a member of the steroid hormone receptor family) status has become increasingly important as both a prognostic marker and potential therapeutic target in breast cancer. AR is expressed in up to 90% of estrogen receptor (ER) positive breast cancer, and to a lesser degree, human epidermal growth factor 2 (HER2) amplified tumors. In the former, AR signaling has been correlated with a better prognosis given its inhibitory activity in estrogen dependent disease, though conversely has also been shown to increase resistance to anti-estrogen therapies such as tamoxifen...
February 24, 2017: Cancers
https://www.readbyqxmd.com/read/28244160/risk-and-blood-borne-virus-testing-among-men-who-inject-image-and-performance-enhancing-drugs-sydney-australia
#20
Rachel Rowe, Israel Berger, Bilal Yaseen, Jan Copeland
INTRODUCTION AND AIMS: Needle and syringe program (NSP) workers have highlighted that people who inject image and performance enhancing drugs (IPED) in Australia are a younger and more culturally and linguistically diverse (CALD) group compared with other groups who inject drugs. Previous research has found riskier injecting practices and faster Hepatitis C acquisition rates among people who are new to injecting drugs and self-identify with CALD backgrounds, compared with their Anglo-Australian counterparts...
February 28, 2017: Drug and Alcohol Review
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