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https://www.readbyqxmd.com/read/28822259/ambient-air-pollution-temperature-and-kawasaki-disease-in-shanghai-china
#1
Zhijing Lin, Xia Meng, Renjie Chen, Guoying Huang, Xiaojing Ma, Jingjing Chen, Min Huang, Meirong Huang, Yonghao Gui, Chen Chu, Fang Liu, Haidong Kan
Kawasaki disease (KD) is a kind of pediatric vasculitis of unknown etiology which mainly affects the development of coronary artery aneurysms. Few studies have explored the potential environmental risk factors on KD incidence. We performed a time-series analysis to investigate the associations between air pollution and temperature and KD in Shanghai, China. We collected daily-hospitalized KD patients that were admitted in major pediatric specialty hospitals located in the urban areas of Shanghai from 2001 to 2010...
August 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28822209/primary-culture-of-rat-aortic-vascular-smooth-muscle-cells-a-new-method
#2
Jufang Chi, Liping Meng, Sunlei Pan, Hui Lin, Xiaoya Zhai, Longbin Liu, Changzuan Zhou, Chengjian Jiang, Hangyuan Guo
BACKGROUND Developing a simple and efficient method of obtaining primary cultured VSMCs is necessary for basic cardiovascular research. MATERIAL AND METHODS The procedure of our new method mainly includes 6 steps: isolation of the aortic artery, removal of the fat tissue around the artery, separation of the media, cutting the media into small tissue blocks, transferring the tissue blocks to cell culture plates, and incubation until the cells reach confluence. The cells were identified as VSMCs by morphology and immunofluorescence...
August 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28822192/-taurine-affects-expression-of-icam-1-vcam-1-by-p38-pathway-in-hypoxic-endothelial-cells
#3
Xiao-Dan Zhang, Shu-Ya Zhao, Yun-Lin Li, Da-Ling Zhu, Ru Zhang, Jie-Jing Sheng, Shu-Jing Wang
To investigate the effect of taurine(Tau) on ICAM-1, VCAM-1 by p-p38 pathway in bovine pulmonary artery endothelial cells(PAECs) and explore its mechanism of action. Generation 4-12 cells in primary cultures of PAECs were used in experiments and divided into five groups: control group, hypoxia(hyp) group, inhibitor(SB203580) group, treatment(Tau) group, and treatment+inhibitor(SB+Tau) group. The concentration of Tau:100 mmol•L⁻¹; p38 inhibitor SB203580: 20 μmol•L⁻¹; and the treatment time was 12 h...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822163/-mechanism-of-treatment-effect-of-huanglian-huangqin-herb-pairs-on-cerebral-ischemia-rats-based-on-metabolomic-approach
#4
Hui-Ting Cao, Hua-Xu Zhu, Qi-Chun Zhang, Li-Wei Guo
The metabolic effect of Huanglian-Huangqin herb pairs on cerebral ischemia rats was studied by using metabolomic method. The rat model of ischemia reperfusion injury induced by introduction of transient middle cerebral artery occlusion (MCAO) followed by reperfusion. Ultra high performance liquid chromatography-series four pole time of flight mass spectrometry method(UPLC-Q-TOF/MS), Markerlynx software, and principal component analysis and partial least-squares discriminant analysis were used to analyze the different endogenous metabolites among the urine samples of sham rats, cerebral ischemia model rats, Huanglian groups (HL), Huangqin groups (HQ) and Huanglian-Huangqin herb pairs groups (LQ) was achieved, combined with accurate information about the endogenous metabolites level and secondary fragment ions, retrieval and identification of possible biological markers, metabolic pathway which build in MetPA database...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822160/-effects-of-active-components-group-of-xiaoxuming-decoction-on-brain-mitochondria-in-cerebral-ischemia-reperfusion-rats-during-early-recovery-period
#5
Xiao Du, Chang Lu, Xiao-Li He, Guan-Hua Du
To observe the effect of active components group of Xiaoxuming decoction (XXMD) on brain mitochondria in cerebral ischemia/reperfusion rats during early recovery period, and study its protective mechanism for nerves in cerebral ischemia/reperfusion rats during early recovery period. Cerebral ischemia model of middle cerebral artery occlusion in rats was established by suture method, and reperfusion was conducted 2 h later. The degree of cerebral ischemia in rats was evaluated by using Zea-Longa's standard grading method, and the model rats were randomly divided into model group, Xiaoxuming decoction active components low, medium and high dose groups and positive drug Ginaton group, with sham operated rats as control group...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822101/revisiting-the-logan-plot-to-account-for-non-negligible-blood-volume-in-brain-tissue
#6
Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin, Andrea Varrone
BACKGROUND: Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study, we seek to revisit the well-established Logan plot and derive alternative formulations that provide estimation of distribution volume ratios (DVRs) that are corrected for the signal originating from the vasculature...
August 18, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28822090/radial-artery-spasm-should-we-worry
#7
EDITORIAL
Steven B Backman
No abstract text is available yet for this article.
August 18, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28822077/increased-serum-levels-of-fetuin-b-in-patients-with-coronary-artery-disease
#8
Kefu Zhu, Yuming Wang, Pengqin Shu, Qinyi Zhou, Jinzhou Zhu, Wenjing Zhou, Changqing Du, Chenkai Xu, Xiaowei Liu, Lijiang Tang
BACKGROUND: Recent evidence indicates a pivotal role for fetuin B, one of the cystatin superfamily of cysteine protease inhibitors, in the pathogenesis of metabolic diseases. This study investigated whether serum fetuin B levels are associated with the presence of coronary artery disease. METHODS: Serum fetuin B levels were assessed in 87 patients with coronary artery disease (41 with acute coronary syndromes and 46 with stable angina pectoris) and 87 healthy controls using an enzyme-linked immunosorbent assay...
August 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28822022/eryptosis-and-oxidative-damage-in-hypertensive-and-dyslipidemic-patients
#9
Carmen Elisa Pinzón-Díaz, José Víctor Calderón-Salinas, Margarita Marcela Rosas-Flores, Gerardo Hernández, Alicia López-Betancourt, Martha Angélica Quintanar-Escorza
Arterial hypertension is a disease that often coexists with dyslipidemia. Both disorders can produce oxidative stress. Studies in vivo and in vitro have proven that oxidative stress can induce an increment of the erythrocyte apoptosis (eryptosis), through the rise of free intracellular calcium concentration ([Ca(2+)]i). Higher levels of eryptosis have not been described in patients with hypertension, dyslipidemia, or both combined. This study involved 81 men between 26 and 50 years old, assorted into four groups: normotensive with and without dyslipidemia, and hypertensive with and without dyslipidemia...
August 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28821962/influence-of-aerobic-fitness-on-vasoreactivity-in-young-men
#10
Preston L Bell, Edward T Kelley, Stephanie M McCoy, Daniel P Credeur
Previous work has demonstrated a direct relationship between aerobic fitness and vasodilatory function (i.e., flow-mediated dilation; FMD); however, the relation between aerobic fitness and vasoconstrictor responsiveness (i.e., low flow-mediated constriction; L-FMC), and the overall vasoactive range (FMD + L-FMC) is unclear. PURPOSE: To test the hypothesis that L-FMC and the overall vasoactive range (FMD + L-FMC) will be related to aerobic fitness in young, healthy men. METHODS: Twenty men (age: 23 ± 5 years) were recruited, and divided evenly into a higher (HF) vs...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28821961/postmortem-evaluation-of-cholesterol-triglyceride-and-apolipoprotein-levels
#11
Charlotte Girard, Maria Pia Scarpelli, Camilla Tettamanti, Cristian Palmiere
Cholesterol and triglyceride levels have been analyzed in the forensic setting and their values correlated with atherosclerotic lesions found at autopsy and histology. Nevertheless, the results of these investigations have provided diverging information on postmortem molecule stability and postmortem measurement reliability. The aim of this study was to determine triglycerides, total cholesterol, low-density and high-density lipoprotein cholesterol, apolipoprotein B100, and apolipoprotein A-I in antemortem and postmortem serum samples in a series of cases (N = 10, including cardiac and noncardiac deaths) that underwent forensic investigations and had both samples available, measure the same molecules in postmortem serum from femoral blood and pericardial and pleural fluids (N = 39, including cardiac and noncardiac deaths), and evaluate whether different levels of these molecules could be observed in cases characterized by different degrees of coronary artery atherosclerosis (N = 39, including cardiac and noncardiac deaths)...
August 18, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28821949/electromagnetically-navigated-in-situ-fenestration-of-aortic-stent-grafts-pilot-animal-study-of-a-novel-fenestrated-evar-approach
#12
Tobias Penzkofer, Hong-Sik Na, Peter Isfort, Christoph Wilkmann, Sabine Osterhues, Andreas Besting, Christoph Hänisch, Stefan Bisplinghoff, Johannes Jansing, Sylvie von Werder, Jorge Gooding, Mathias de la Fuente, Andreas H Mahnken, Catherine Disselhorst-Klug, Thomas Schmitz-Rode, Christiane Kuhl, Philipp Bruners
PURPOSE: Assess electromagnetically guided in situ fenestration of juxtarenal aortic stent grafts in an in vivo model. METHODS: Using a newly developed electromagnetic guidance system together with a modified, electromagnetically guidable catheter with steerable tip, an electromagnetically trackable guidewire and a custom in situ fenestrateable stent graft, a series of seven animal experiments was performed. In a swine model, stent grafts were placed juxtarenally, covering the renal arteries...
August 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28821915/risk-and-outcomes-of-fracture-in-peripheral-arterial-disease-patients-two-nationwide-cohort-studies
#13
F-L Liu, C-S Lin, C-C Yeh, C-C Shih, Y-G Cherng, C-H Wu, T-L Chen, C-C Liao
Using national insurance claims data of Taiwan, we found that patients with peripheral arterial disease (PAD) had increased risk of fracture during the follow-up period of 2000-2013. History of PAD was also associated with adverse outcomes in hospitalized fracture patients. Prevention strategies were needed in this susceptible population. INTRODUCTION: Limited information was available on the association between PAD and fracture. The purpose of this study is to evaluate fracture risk and post-fracture outcomes in patients with PAD...
August 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28821815/epac1-deficient-mice-have-bleeding-phenotype-and-thrombocytes-with-decreased-gpib%C3%AE-expression
#14
Gyrid Nygaard, Lars Herfindal, Kathrine S Asrud, Ronja Bjørnstad, Reidun K Kopperud, Eystein Oveland, Frode S Berven, Lene Myhren, Erling A Hoivik, Turid Helen Felli Lunde, Marit Bakke, Stein O Døskeland, Frode Selheim
Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1(-/-) mice, but not Epac2(-/-) mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The Epac1(-/-) mice had deficient in vitro secondary hemostasis. Quantitative comprehensive proteomics analysis revealed that Epac1(-/-) mouse platelets (thrombocytes) had unbalanced expression of key components of the glycoprotein Ib-IX-V (GPIb-IX-V) complex, with decrease of GP1bβ and no change of GP1bα...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821752/hybrid-nitric-oxide-donor-and-its-carrier-for-the-treatment-of-peripheral-arterial-diseases
#15
Duong Q Le, Aneetta E Kuriakose, Dat X Nguyen, Kytai T Nguyen, Suchismita Acharya
Nitric oxide (NO) has been known to promote physiological angiogenesis to treat peripheral arterial diseases (PAD) by increasing the vascular endothelial growth factor (VEGF) level in endothelial cells (ECs) and preventing platelet adherence and leukocyte chemotaxis. However, the ongoing ischemic event during peripheral ischemia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion. Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs against hydrogen peroxide-induced oxidative stress...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821715/invasive-trophoblast-promote-stromal-fibroblast-decidualization-via-profilin-1-and-alox5
#16
E M Menkhorst, M L Van Sinderen, K Rainczuk, C Cuman, A Winship, E Dimitriadis
During the establishment of pregnancy, extravillous trophoblast (EVT) must invade into the uterine decidua to facilitate decidual artery remodelling to create the placental blood supply. The local decidual environment is thought to regulate trophoblast invasion, however these interactions are poorly defined in humans. Recent evidence in women suggests impaired decidualization is associated with miscarriage and preeclampsia. Primary human endometrial stromal cells (HESC) and first trimester extravillous trophoblast (EVTs) were used to assess the effect of EVT-secreted factors on HESC decidualization, adhesion, proliferation and migration...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821620/arjunolic-acid-a-peroxisome-proliferator-activated-receptor-alpha-agonist-regresses-cardiac-fibrosis-by-inhibiting-non-canonical-tgf-%C3%AE-signaling
#17
Trisha Bansal, Emeli Chatterjee, Jasdeep Singh, Arjun Ray, Bishwajit Kundu, V Thankamani, Shantanu Sengupta, Sagartirtha Sarkar
Cardiac hypertrophy and associated heart fibrosis remain a major cause of death worldwide. Phytochemicals have gained attention as alternative therapeutics for managing cardiovascular diseases. These include the extract from the plant Terminalia arjuna which is a popular cardioprotectant and may prevent or slow progression of pathological hypertrophy to heart failure. Here, we investigated the mode of action of a principal bioactive T. arjuna compound, arjunolic acid (AA) in ameliorating hemodynamic load-induced cardiac fibrosis and identified its intracellular target...
August 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821435/model-based-population-pk-pd-analysis-of-furosemide-for-bp-lowering-effect-a-comparative-study-in-primary-and-secondary-hypertension
#18
Mahendra Shukla, Moustafa M A Ibrahim, Moon Jain, Swati Jaiswal, Abhisheak Sharma, Kashif Hanif, Jawahar Lal
Though numerous reports have demonstrated multiple mechanisms by which furosemide can exert its anti-hypertensive response. However, lack of studies describing PK-PD relationship for furosemide featuring its anti-hypertensive property has limited its usage as a blood pressure (BP) lowering agent. Serum concentrations and mean arterial BP were monitored following 40 and 80mgkg(-1) multiple oral dose of furosemide in spontaneously hypertensive rats (SHR) and DOCA-salt induced hypertensive (DOCA-salt) rats. A simultaneous population PK-PD relationship using Emax model with effect compartment was developed to compare the anti-hypertensive efficacy of furosemide in these rat models...
August 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28821174/veins-to-arteries
#19
Mark Nicholls
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28821170/esc-joint-working-groups-on-cardiovascular-surgery-and-the-cellular-biology-of-the-heart-position-paper-perioperative-myocardial-injury-and-infarction-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#20
Matthias Thielmann, Vikram Sharma, Nawwar Al-Attar, Heerajnarain Bulluck, Gianluigi Bisleri, Jeroen Jh Bunge, Martin Czerny, Péter Ferdinandy, Ulrich H Frey, Gerd Heusch, Johannes Holfeld, Petra Kleinbongard, Gudrun Kunst, Irene Lang, Salvatore Lentini, Rosalinda Madonna, Patrick Meybohm, Claudio Muneretto, Jean-Francois Obadia, Cinzia Perrino, Fabrice Prunier, Joost P G Sluijter, Linda W Van Laake, Miguel Sousa-Uva, Derek J Hausenloy
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
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