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SIR-Spheres Microspheres

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https://www.readbyqxmd.com/read/27876284/calculation-of-tumour-and-normal-tissue-biological-effective-dose-in-90-y-liver-radioembolization-with-different-dosimetric-methods
#1
Elena Gallio, Elisa Richetta, Monica Finessi, Michele Stasi, Riccardo Emanuele Pellerito, Gianni Bisi, Roberto Ropolo
PURPOSE: Radioembolization with (90)Y microspheres is an effective treatment for unresectable liver tumours. Two types of microspheres are available: resin (SIR-Spheres®) and glass (Theraspheres®). The aim of this study is to compare biological effective dose (BED) values obtained with three different dosimetric methods. METHODS: 29 HCC patients were included in this study: 15 were treated with resin(mean injected activity 1.5GBq, range 0.8-2.7GBq) and 14 with glass microspheres (2...
November 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27821083/single-administration-of-selective-internal-radiation-therapy-versus-continuous-treatment-with-sorafenib-in-locally-advanced-hepatocellular-carcinoma-sirvenib-study-protocol-for-a-phase-iii-randomized-controlled-trial
#2
Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew, Pierce K H Chow
BACKGROUND: Approximately 20 % of hepatocellular carcinoma (HCC) patients diagnosed in the early stages may benefit from potentially curative ablative therapies such as surgical resection, transplantation or radiofrequency ablation. For patients not eligible for such options, prognosis is poor. Sorafenib and Selective Internal Radiation Therapy (SIRT) are clinically proven treatment options in patients with unresectable HCC, and this study aims to assess overall survival following either SIRT or Sorafenib therapy for locally advanced HCC patients...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27390539/yttrium-90-selective-internal-radiation-therapy-with-glass-microspheres-for-hepatocellular-carcinoma-current-and-updated-literature-review
#3
REVIEW
Edward Wolfgang Lee, Lourdes Alanis, Sung-Ki Cho, Sammy Saab
Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27155761/failure-mode-and-effects-analysis-in-a-dual-product-microsphere-brachytherapy-environment
#4
Kelly Cooper Younge, Choonik Lee, Jean M Moran, Mary Feng, Paula Novelli, Joann I Prisciandaro
PURPOSE: We performed a failure mode and effects analysis (FMEA) during the addition of a new microspheres product into our existing microsphere brachytherapy program to identify areas for safety improvements. METHODS AND MATERIALS: A diverse group of team members from the microsphere program participated in the project to create a process map, identify and score failure modes, and discuss programmatic changes to address the highest ranking items. We developed custom severity ranking scales for staff- and institution-related failure modes to encompass possible risks that may exist outside of patient-based effects...
March 16, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/26712330/standardisation-of-90-y-and-determination-of-calibration-factors-for-90-y-microspheres-resin-for-the-npl-secondary-ionisation-chamber-and-a-capintec-crc-25r
#5
Kelley M Ferreira, Andrew J Fenwick, Arzu Arinc, Lena C Johansson
The use of (90)Y resin microspheres (SIR-Spheres® microspheres) in Nuclear Medicine has dramatically increased in recent years due to its favourable outcome in the treatment of liver cancer and liver metastases (Rajekar et al., 2011). The measurement of administered activity before and residual activity after treatment in radionuclide calibrators is required to determine total activity delivered to the patient. In comparison with External Beam Radiotherapy (EBRT) where administered doses are often know to within ±5%, the actual administered activity in nuclear medicine procedures may only be known to within ±20% and subsequent dose calculations can result in even larger uncertainties (Fenwick et al...
March 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/26651176/investigation-of-the-response-variability-of-ionization-chambers-for-the-standard-transfer-of-sir-spheres-%C3%A2
#6
C Thiam, C Bobin, V Lourenço, V Chisté, M-N Amiot, X Mougeot, D Lacour, F Rigoulay, L Ferreux
The present paper addresses the calibration of well-type ionization chambers (ICs) used at LNE-LNHB as standard transfer instruments to calibrate hospitals in the case of SIR-Spheres(®)(90)Y resin microspheres (Sirtex, Australia). Developed for interventional oncology, this radiopharmaceutical is directly injected in the liver for cancer treatment via a selective internal radiation therapy. The present work was carried out in the framework of the European project "Metrology for molecular radiotherapy" (MetroMRT)...
March 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/26315830/predictive-value-of-99mtc-maa-spect-for-90y-labeled-resin-microsphere-distribution-in-radioembolization-of-primary-and-secondary-hepatic-tumors
#7
Harun Ilhan, Anna Goritschan, Philipp Paprottka, Tobias F Jakobs, Wolfgang P Fendler, Andrei Todica, Peter Bartenstein, Marcus Hacker, Alexander R Haug
UNLABELLED: This study analyzed the predictive value of (99m)Tc-labeled macroaggregated albumin ((99m)Tc-MAA) SPECT for (90)Y-labeled resin microsphere therapy (radioembolization) by comparing uptake on pretherapeutic (99m)Tc-MAA SPECT with uptake on posttherapeutic (90)Y-bremsstrahlung SPECT. METHODS: We included 502 patients (55% male; mean age ± SD, 62 ± 11 y) who underwent radioembolization between 2005 and 2013 because of primary or secondary liver malignancies (colorectal cancer [n = 195, 38...
November 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26133627/-90-y-pet-imaging-exploring-limitations-and-accuracy-under-conditions-of-low-counts-and-high-random-fraction
#8
Thomas Carlier, Kathy P Willowson, Eugene Fourkal, Dale L Bailey, Mohan Doss, Maurizio Conti
PURPOSE: (90)Y -positron emission tomography (PET) imaging is becoming a recognized modality for postinfusion quantitative assessment following radioembolization therapy. However, the extremely low counts and high random fraction associated with (90)Y -PET may significantly impair both qualitative and quantitative results. The aim of this work was to study image quality and noise level in relation to the quantification and bias performance of two types of Siemens PET scanners when imaging (90)Y and to compare experimental results with clinical data from two types of commercially available (90)Y microspheres...
July 2015: Medical Physics
https://www.readbyqxmd.com/read/26129385/we-g-bra-09-microsphere-brachytherapy-failure-mode-and-effects-analysis-in-a-dual-vendor-environment
#9
K C Younge, C I Lee, M Feng, P Novelli, J M Moran, J I Prisciandaro
PURPOSE: To improve the safety and quality of a dual-vendor microsphere brachytherapy program with failure mode and effects analysis (FMEA). METHODS: A multidisciplinary team including physicists, dosimetrists, a radiation oncologist, an interventional radiologist, and radiation safety personnel performed an FMEA for our dual-vendor microsphere brachytherapy program employing SIR-Spheres (Sirtex Medical Limited, Australia) and Theraspheres (BTG, England). We developed a program process tree and step-by-step instructions which were used to generate a comprehensive list of failure modes...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128591/mo-ab-201-03-the-alphabet-soup-of-regulatory-compliance-being-prepared-for-inspections
#10
L Kroger
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128589/mo-ab-201-01-regulatory-compliance-and-safety-with-new-radiotherapies-spheres-and-ra-223
#11
L Phillips
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128588/mo-ab-201-02-the-rso-and-the-rsc-challenges-and-opportunities
#12
C Dimock
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128587/mo-ab-201-00-radiation-safety-officer-update
#13
(no author information available yet)
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/25941769/cost-effectiveness-of-selective-internal-radiation-therapy-using-yttrium-90-resin-microspheres-in-treating-patients-with-inoperable-colorectal-liver-metastases-in-the-uk
#14
B Pennington, R Akehurst, H Wasan, B Sangro, A S Kennedy, K Sennfält, L Bester
OBJECTIVE: Selective internal radiation therapy (SIRT) using SIR-Spheres(®) (90)Y-labeled resin microspheres has been shown to be a well-tolerated, effective treatment in patients with inoperable liver-dominant chemotherapy-refractory metastatic colorectal cancer (mCRC). This study estimated the cost-effectiveness of (90)Y-resin microspheres compared to best supportive care (BSC) from a UK perspective. METHODS: Survival data from a comparative retrospective cohort study was analyzed and used in a state-transition cost-effectiveness model, using quality-adjusted life years (QALYs) gained as the measure of effectiveness...
2015: Journal of Medical Economics
https://www.readbyqxmd.com/read/25937772/transcatheter-embolization-therapy-in-liver-cancer-an-update-of-clinical-evidences
#15
REVIEW
Yì-Xiáng J Wáng, Thierry De Baere, Jean-Marc Idée, Sébastien Ballet
Transarterial chemoembolization (TACE) is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization. Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma (HCC) patients who cannot receive potentially curative therapies such as transplantation, resection or percutaneous ablation. TACE for liver cancer has been proven to be useful in local tumor control, to prevent tumor progression, prolong patients' life and control patient symptoms...
April 2015: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/25579458/primary-standardization-of-sir-spheres-based-on-the-dissolution-of-the-90-y-labeled-resin-microspheres
#16
V Lourenço, C Bobin, V Chisté, D Lacour, F Rigoulay, M Tapner, C Thiam, L Ferreux
The project "Metrology for molecular radiotherapy" is a collaborative European project initiated to bring together expertize in ionizing radiation metrology and nuclear medicine research. This project deals with the development of personalized dosimetry to individual patients who are undergoing molecular radiotherapy (also known as targeted radionuclide therapy). The general aim is to provide a metrological traceability to primary standards for individual dosimetry in the case of molecular radiotherapy. In particular, one objective is the standardization of (90)Y-labeled resin microspheres SIR-Spheres (Sirtex, Sydney, Australia) used for the treatment of liver cancer by radioembolization...
March 2015: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/25563137/evaluation-of-factors-affecting-tumor-response-and-survival-in-patients-with-primary-and-metastatic-liver-cancer-treated-with-microspheres
#17
Serkan Demirelli, Metin Erkilic, Ali Ozan Oner, Evrim Surer Budak, Seyda Gunduz, Ozhan Ozgur, Hakan Bozcuk, Hakki Timur Sindel, Adil Boz
OBJECTIVE: Radioembolization with the yttrium-90 (Y-90) microspheres is being used increasingly more often in the treatment of patients with primary or metastatic liver cancer. Although technetium-99m macroaggregated albumin (Tc-99m MAA) scintigraphy performed following diagnostic angiography has an important role in predicting the effectiveness of treatment and in dose estimation, the number of studies using quantitative assessment of Tc-99m MAA scintigraphy is limited in this field...
April 2015: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/25472660/radioembolisation-with-yttrium%C3%A2-90-microspheres-versus-sorafenib-for-treatment-of-advanced-hepatocellular-carcinoma-sarah-study-protocol-for-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Valérie Vilgrain, Mohamed Abdel-Rehim, Annie Sibert, Maxime Ronot, Rachida Lebtahi, Laurent Castéra, Gilles Chatellier
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, there are no head-to-head trials comparing radiation therapy with yttrium-90 microspheres and sorafenib in advanced HCC. The SARAH trial has been designed to compare the efficacy and safety of sorafenib therapy and RE using yttrium-90 resin microspheres (SIR-Spheres™; Sirtex Medical Limited, North Sydney, Australia) in patients with advanced HCC...
2014: Trials
https://www.readbyqxmd.com/read/25272027/90sr-content-in-90y-labeled-sir-spheres-and-zevalin
#19
John Metyko, William Erwin, John Poston, Sandra Jimenez
Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product...
November 2014: Health Physics
https://www.readbyqxmd.com/read/25186412/pet-optimization-for-improved-assessment-and-accurate-quantification-of-90y-microsphere-biodistribution-after-radioembolization
#20
Josep M Martí-Climent, Elena Prieto, César Elosúa, Macarena Rodríguez-Fraile, Inés Domínguez-Prado, Carmen Vigil, María J García-Velloso, Javier Arbizu, Iván Peñuelas, José A Richter
PURPOSE: 90Y-microspheres are widely used for the radioembolization of metastatic liver cancer or hepatocellular carcinoma and there is a growing interest for imaging 90Y-microspheres with PET. The aim of this study is to evaluate the performance of a current generation PET/CT scanner for 90Y imaging and to optimize the PET protocol to improve the assessment and the quantification of 90Y-microsphere biodistribution after radioembolization. METHODS: Data were acquired on a Biograph mCT-TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling...
September 2014: Medical Physics
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