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https://www.readbyqxmd.com/read/28193514/microrna-301a-promotes-intestinal-inflammation-and-colitis-associated-cancer-development-by-inhibiting-btg1
#1
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A), compared to tissues from patients without IBD. We studied the mechanisms of MIR301A in progression of IBD in human tissues and mice. METHODS: We isolated intestinal epithelial cells (IECs) from colon biopsy samples of 153 patients with different stages of IBD activity, 6 patients with colitis-associated cancer (CAC), and 35 healthy individuals (controls), enrolled in the study in Shanghai, China...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28183228/btg3-overexpression-suppresses-the-proliferation-and-invasion-in-epithelial-ovarian-cancer-cell-by-regulating-akt-gsk3%C3%AE-%C3%AE-catenin-signaling
#2
Qi An, Yan Zhou, Chao Han, Yubing Zhou, Feng Li, Duolu Li
Epithelial ovarian cancer (EOC) is the leading cause of cancer-related death among all the gynecological malignancies of the female genital system, and its incidence and mortality rates continue to rise. B-cell translocation gene 3 (BTG3) plays an important role in the occurrence and development of numerous cancers. However, the role of BTG3 in EOC remains poorly understood. In this study, we aimed to investigate the biological role and potential molecular mechanism of BTG3 in EOC. We found that BTG3 protein expression was significantly lower in human EOC cell lines...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/27981534/the-anxiolitic-effects-of-btg1640-and-btg1675a-on-ultrasonic-isolation-calls-and-locomotor-activity-of-rat-pups
#3
M Niculescu, R Cagiano, M Caprio, S Damian, E Boia, D Vermesan, M Tattoli, H Haragus
OBJECTIVE: The aim of the present study was to evaluate the anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A in comparison with diazepam. MATERIALS AND METHODS: We evaluated the ultrasonic distress emission in both sexes of neonatal rat pups (which seems to be a sensitive indicator of the rat emotional reactivity and represents a valuable tool to screen compounds with expected anxiolytic properties) and the locomotor activity in 30-day old rat pups...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27940367/the-b-cell-translocation-gene-1-cgbtg1-identified-in-oyster-crassostrea-gigas-exhibit-multiple-functions-in-immune-response
#4
Rui Liu, Qi Cheng, Xiudan Wang, Hao Chen, Weilin Wang, Huan Zhang, Lingling Wang, Linsheng Song
B-cell translocation gene 1 (BTG1) is a member of the anti-proliferative gene family, which plays important roles in regulation of cell cycle. In the present study, a B-cell translocation gene 1 molecule homologue (designed CgBTG1) are identified and characterized in oyster Crassostrea gigas. CgBTG1 contains a conserved BTG domain with Box A and Box B motifs, and it shares high similarities with both BTG1 and BTG2 proteins in vertebrates. CgBTG1 mRNA is predominantly expressed in hemocytes, and its expression level in hemocytes is significantly up-regulated at 6 h (5...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27697946/estimating-cigarette-tax-avoidance-and-evasion-evidence-from-a-national-sample-of-littered-packs
#5
Dianne C Barker, Shu Wang, David Merriman, Andrew Crosby, Elissa A Resnick, Frank J Chaloupka
INTRODUCTION: A number of recent studies document the proportion of all cigarette packs that are 'contraband' using discarded packs to measure tax avoidance and evasion, which we call tax non-compliance. To date, academic studies using discarded packs focused on relatively small geographical areas such as a city or a neighbourhood. METHODS: We visited 160 communities across 38 US states in 2012 and collected data from littered cigarette packs as part of the State and Community Tobacco Control (SCTC) Research Initiative and the Bridging the Gap Community Obesity Measures Project (BTG-COMP)...
October 2016: Tobacco Control
https://www.readbyqxmd.com/read/27686221/a-novel-reference-security-model-with-the-situation-based-access-policy-for-accessing-ephr-data
#6
Prosanta Gope, Ruhul Amin
Electronic Patient Health Record (EPHR) systems may facilitate a patient not only to share his/her health records securely with healthcare professional but also to control his/her health privacy, in a convenient and easy way even in case of emergency. In order to fulfill these requirements, it is greatly desirable to have the access control mechanism which can efficiently handle every circumstance without negotiating security. However, the existing access control mechanisms used in healthcare to regulate and restrict the disclosure of patient data are often bypassed in case of emergencies...
November 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27672505/tissue-and-serum-samples-of-patients-with-papillary-thyroid-cancer-with-and-without-benign-background-demonstrate-different-altered-expression-of-proteins
#7
Mardiaty Iryani Abdullah, Ching Chin Lee, Sarni Mat Junit, Khoon Leong Ng, Onn Haji Hashim
BACKGROUND: Papillary thyroid cancer (PTC) is mainly diagnosed using fine-needle aspiration biopsy. This most common form of well-differentiated thyroid cancer occurs with or without a background of benign thyroid goiter (BTG). METHODS: In the present study, a gel-based proteomics analysis was performed to analyse the expression of proteins in tissue and serum samples of PTC patients with (PTCb; n = 6) and without a history of BTG (PTCa; n = 8) relative to patients with BTG (n = 20)...
2016: PeerJ
https://www.readbyqxmd.com/read/27379194/frtl-5-rat-thyroid-cells-release-thyroglobulin-sequestered-in-exosomes-a-possible-novel-mechanism-for-thyroglobulin-processing-in-the-thyroid
#8
Pavel Vlasov, Sonia Q Doi, Donald F Sellitti
Exosomes are 30-100 nm, membrane-bound vesicles containing specific cellular proteins, mRNAs, and microRNAs that take part in intercellular communication between cells. A possible role for exosomes in thyroid function has not been fully explored. In the present study, FRTL-5 rat thyroid cells were grown to confluence and received medium containing either thyroid stimulating hormone (TSH), exogenous bovine thyroglobulin (bTg), or neither additive for 24 or 48 hours followed by collection of spent medium and ultracentrifugation to isolate small vesicles...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27259737/analysis-of-30-biallelic-indel-markers-using-the-investigator-dipplex-%C3%A2-kit
#9
Majid Bashir, Nur Haliza Bt Hassan
Insertion/deletion polymorphisms (INDELs) are a relatively new class of a DNA marker to be used in forensic casework; used most commonly as a supplementary method to STR-based typing. INDELs, like SNPs, are particularly useful for the analysis of highly degraded DNA as the amplicon sizes are typically below 160 bp; they can also be valuable as an additional tool to help resolve kinship cases, with the advantage over STRs that they do not have high mutation rates. INDELs have an advantage over SNPs in that they are length polymorphisms and so can be analyzed by simply measuring the length of the allele(s)...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27013511/a-multicenter-randomized-placebo-controlled-study-to-evaluate-the-efficacy-and-safety-of-varithena%C3%A2-polidocanol-endovenous-microfoam-1-for-symptomatic-visible-varicose-veins-with-saphenofemoral-junction-incompetence
#10
Kathleen Gibson, Lowell Kabnick
OBJECTIVES: A randomized, placebo-controlled, multicenter study was conducted to evaluate the safety and efficacy of polidocanol endovenous microfoam (1%, Varithena® [polidocanol injectable foam], BTG International Ltd.). METHODS: Patients (n = 77) with symptomatic, visible varicose veins were randomized to treatment with either Varithena 1% or placebo. RESULTS: Varithena provided greater mean changes from Baseline in patient-reported assessments of symptoms (e...
March 24, 2016: Phlebology
https://www.readbyqxmd.com/read/26992303/durability-of-treatment-effect-with-polidocanol-endovenous-microfoam-on-varicose-vein-symptoms-and-appearance-vanish-2
#11
Kenneth L Todd, David I Wright
OBJECTIVE: The objectives of this study were to assess the durability of response to treatment with polidocanol endovenous microfoam (Varithena; Provensis Ltd, a BTG International group company) and to assess the long-term safety of the study patients. METHODS: This report presents efficacy and safety data from the day after visit 5/week 8 (the primary end point of the study) through the 1-year study visit. As the approved dose concentration is 1%, this analysis focuses on those patients who were randomized to polidocanol endovenous microfoam 1% at study visit 2...
July 2015: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/26957489/a-multicenter-randomized-placebo-controlled-trial-of-endovenous-thermal-ablation-with-or-without-polidocanol-endovenous-microfoam-treatment-in-patients-with-great-saphenous-vein-incompetence-and-visible-varicosities
#12
Michael Vasquez, Antonios P Gasparis
OBJECTIVES: *Varithena 017 Investigator Group: Michael Vasquez, MD, Venous Institute of Buffalo, Amherst, NY; Antonios Gasparis, MD, Stony Brook University Medical Center, Stony Brook, NY; Kathleen Gibson, MD, Lake Washington Vascular, Bellevue, WA; James Theodore King, MD, Vein Clinics of America, Oakbrook Terrace, IL; Nick Morrison, MD, Morrison Vein Institute, Scottsdale, AZ; Girish Munavalli, MD, Dermatology, Laser & Vein Specialists of the Carolinas, Charlotte, NC; Eulogio J. Sanchez, MD, Batey Cardiovascular Center, Bradenton, FL...
March 7, 2016: Phlebology
https://www.readbyqxmd.com/read/26912148/btg2-bridges-pabpc1-rna-binding-domains-and-caf1-deadenylase-to-control-cell-proliferation
#13
Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion
While BTG2 plays an important role in cellular differentiation and cancer, its precise molecular function remains unclear. BTG2 interacts with CAF1 deadenylase through its APRO domain, a defining feature of BTG/Tob factors. Our previous experiments revealed that expression of BTG2 promoted mRNA poly(A) tail shortening through an undefined mechanism. Here we report that the APRO domain of BTG2 interacts directly with the first RRM domain of the poly(A)-binding protein PABPC1. Moreover, PABPC1 RRM and BTG2 APRO domains are sufficient to stimulate CAF1 deadenylase activity in vitro in the absence of other CCR4-NOT complex subunits...
2016: Nature Communications
https://www.readbyqxmd.com/read/26894603/crystal-structure-and-chemotherapeutic-efficacy-of-the-novel-compound-gallium-tetrachloride-betaine-against-breast-cancer-using-nanotechnology
#14
Ahmed Salem, Eman Noaman, Eman Kandil, Abdelfattah Badawi, Nihal Mostafa
The objective of this study was to investigate the antitumor efficacy of a novel synthesized compound, betaine gallium-tetrachloride (BTG), alone or combined with ZnO-nanoparticles (BTG + ZnO-NPs) on the incidence of 7, 12-dimethylbenz-anthrathene-induced mammary tumor in female rats. Crystal and molecular structure of the prepared BTG were identified using X-ray crystallography. In vitro study revealed BTG more cytotoxic than BTG + ZnO-NPs on human breast cancer (MCF-7) cell line. In vivo study demonstrated that the blood antioxidant status of tumor-bearing rats (DMBA group) was significantly lower than normal noticeable by a significant decrease in GSH content, GPx, SOD, and CAT activities associated with a significantly high MDA content...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26887657/asia-pacific-hematology-consortium-report-on-approach-to-multiple-myeloma-survey-results-from-the-6th-international-hematologic-malignancies-conference-bridging-the-gap-2015-beijing-china
#15
Jin Lu, Jian Hou, Kai-Yan Liu, Simrit Parmar, Adolfo De La Fuente, Börje Andersson, ChenHua Yan, Daobin Zhou, Daryl Tan, David Ritchie, Deipei Wu, Elizabeth Shpall, Ginna G Laport, JianYong Li, Jiong Hu, Lian Sheng Zhang, Michael Wang, Pankaj Malhotra, Qian Jiang, Yazhen Qin, Raymond Wong, Richard Champlin, Surapol Issaragrisil, Swaminathan Iyer, Vikram Mathews, Yu Wang, Yu Hu, Zhijian Xiao, Zonghong Shao, Rafael Rosengarten, Jon Steuernagle, Jun Huang Xiao, Robert Orlowski, Chor Sang Chim
The Asia-Pacific Hematology Consortium (APHCON), in partnership with MDRingTM, a mobile global physician education network, has initiated a detailed longitudinal study of physician knowledge and practice preferences in the Asia-Pacific sphere. The first dataset comes from a series of surveys answered by delegates at the APHCON Bridging The Gap (BTG) conference in Beijing in January, 2015. In this report we present our findings regarding diagnosis and treatment of multiple myeloma (MM). We aim to create a conduit for physicians in this region to share their experiences with the rest of the world, to identify areas of consensus and best practices, and to highlight opportunities for improvement in communication, education and patient care...
July 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26853738/oriented-nucleation-of-both-ge-fresnoite-and-benitoite-bage4o9-during-the-surface-crystallisation-of-glass-studied-by-electron-backscatter-diffraction
#16
Wolfgang Wisniewski, Marek Patschger, Steliana Murdzheva, Christian Thieme, Christian Rüssel
Two glasses of the compositions 2 BaO - TiO2 - 2.75 GeO2 and 2 BaO - TiO2 -3.67 GeO2 (also known as BTG55) are annealed at temperatures from 680 to 970 °C to induce surface crystallization. The resulting samples are analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM) including electron backscatter diffraction (EBSD). Ge-Fresnoite (Ba2TiGe2O8, BTG) is observed at the immediate surface of all samples and oriented nucleation is proven in both compositions. After a very fast kinetic selection, the crystal growth of BTG into the bulk occurs via highly oriented dendrites where the c-axes are oriented perpendicular to the surface...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26841421/btg-ac-break-the-glass-access-control-model-for-medical-data-in-wireless-sensor-networks
#17
Htoo Maw, Hannan Xiao, Bruce Christianson, James Malcolm
Wireless Sensor Networks (WSNs) have recently attracted much interest in the research community because of their wide range of applications. An emerging application for WSNs involves their use in healthcare where they are generally termed Wireless Medical Sensor Networks (WMSNs). In a hospital, outfitting every patient with tiny, wearable, wireless vital sign sensors would allow doctors, nurses and other caregivers to continuously monitor the state of their patients. In such a scenario, patients are expected to be treated in reasonable time, so, an access control model is needed which will provide both real-time access to comprehensive medical records and detect unauthorised access to sensitive data...
December 22, 2015: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/26840354/effect-of-low-intensity-therapeutic-ultrasound-on-wound-healing-in-rats-subjected-to-third-degree-burns
#18
Rayanne Lisboa Mesquita, Pedro Iuri Castro da Silva, Simone Haru Sawaki de Melo e Silva, Kathlen Oliveira De Oliveira, Aldo José Fontes-Pereira, Jofre Jacob da Silva Freitas, Wagner Coelho De Albuquerque Pereira, Katia Simone Kietzer
PURPOSE: To determine the effectiveness of low-intensity therapeutic ultrasound (LITUS) on wound healing in rats with third-degree burns. METHODS: Twenty rats were divided into the Control Group that comprised four rats without third-degree burns that did not undergo LITUS, the Burned Group (BG), comprising eight rats with third-degree burns that did not undergo LITUS, and the Burned with Treatment Group (BTG), comprising eight rats with third-degree burns that were administered LITUS...
January 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/26738192/inference-of-nonlinear-gene-regulatory-networks-through-optimized-ensemble-of-support-vector-regression-and-dynamic-bayesian-networks
#19
Arinze Akutekwe, Huseyin Seker
Comprehensive understanding of gene regulatory networks (GRNs) is a major challenge in systems biology. Most methods for modeling and inferring the dynamics of GRNs, such as those based on state space models, vector autoregressive models and G1DBN algorithm, assume linear dependencies among genes. However, this strong assumption does not make for true representation of time-course relationships across the genes, which are inherently nonlinear. Nonlinear modeling methods such as the S-systems and causal structure identification (CSI) have been proposed, but are known to be statistically inefficient and analytically intractable in high dimensions...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26662055/tob1-is-expressed-in-developing-and-adult-gonads-and-is-associated-with-the-p-body-marker-dcp2
#20
Farnaz Shapouri, Shaghayegh Saeidi, Robb U de Iongh, Franca Casagranda, Patrick S Western, Eileen A McLaughlin, Jessie M Sutherland, Gary R Hime, Mary Familari
Tob1 is a member of the BTG/TOB family of proteins with established antiproliferative function. In Danio rerio and Xenopus laevis, the Tob1 gene is expressed from the one-cell stage through to early gastrula stages, followed in later development by discrete expression in many tissues including the notochord and somites. In both mouse and human, Tob1 is expressed in many adult tissues including the testis and ovary; however, the specific cell types are unknown. We examine Tob1 gene expression in mouse in developing germ cells and in sorted male germ cells (gonocytes, spermatogonia, pachytene spermatocytes and round spermatids) by reverse transcription and droplet digital polymerase chain reaction (RT-ddPCR) and in adult ovary and testis by immunofluorescence with anti-Tob1 protein staining...
May 2016: Cell and Tissue Research
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