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https://www.readbyqxmd.com/read/27876284/calculation-of-tumour-and-normal-tissue-biological-effective-dose-in-90-y-liver-radioembolization-with-different-dosimetric-methods
#1
Elena Gallio, Elisa Richetta, Monica Finessi, Michele Stasi, Riccardo Emanuele Pellerito, Gianni Bisi, Roberto Ropolo
PURPOSE: Radioembolization with (90)Y microspheres is an effective treatment for unresectable liver tumours. Two types of microspheres are available: resin (SIR-Spheres®) and glass (Theraspheres®). The aim of this study is to compare biological effective dose (BED) values obtained with three different dosimetric methods. METHODS: 29 HCC patients were included in this study: 15 were treated with resin(mean injected activity 1.5GBq, range 0.8-2.7GBq) and 14 with glass microspheres (2...
November 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27390539/yttrium-90-selective-internal-radiation-therapy-with-glass-microspheres-for-hepatocellular-carcinoma-current-and-updated-literature-review
#2
REVIEW
Edward Wolfgang Lee, Lourdes Alanis, Sung-Ki Cho, Sammy Saab
Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27182686/impact-of-the-activity-calculation-method-used-in-transarterial-radioembolization-a-dosimetric-comparison-between-90y-sirsphere-and-90y-therasphere-therapy
#3
Ashish K Jha, Sneha Mithun, Nilendu C Purandare, Sneha A Shah, Archi Agrawal, Suyash S Kulkarni, Nitin Shetty, Venkatesh Rangarajan
PURPOSE: Transarterial radioembolization is used to treat primary and secondary liver malignancies. Two commercially available drugs are utilized for the purpose. The aim of our study is to compare the radiation dose delivered to the tumor by these drugs. MATERIALS AND METHODS: This study included 86 patients (M : F - 7.6 : 1, median age=50.5 years), 46 patients were treated by Y-TheraSphere and 42 patients were treated by Y-SIRSphere. Activity administered in Y-TheraSphere and Y-SIRSphere was calculated using a modified partition model and a modified body surface area model, respectively...
September 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27155761/failure-mode-and-effects-analysis-in-a-dual-product-microsphere-brachytherapy-environment
#4
Kelly Cooper Younge, Choonik Lee, Jean M Moran, Mary Feng, Paula Novelli, Joann I Prisciandaro
PURPOSE: We performed a failure mode and effects analysis (FMEA) during the addition of a new microspheres product into our existing microsphere brachytherapy program to identify areas for safety improvements. METHODS AND MATERIALS: A diverse group of team members from the microsphere program participated in the project to create a process map, identify and score failure modes, and discuss programmatic changes to address the highest ranking items. We developed custom severity ranking scales for staff- and institution-related failure modes to encompass possible risks that may exist outside of patient-based effects...
March 16, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/26133627/-90-y-pet-imaging-exploring-limitations-and-accuracy-under-conditions-of-low-counts-and-high-random-fraction
#5
Thomas Carlier, Kathy P Willowson, Eugene Fourkal, Dale L Bailey, Mohan Doss, Maurizio Conti
PURPOSE: (90)Y -positron emission tomography (PET) imaging is becoming a recognized modality for postinfusion quantitative assessment following radioembolization therapy. However, the extremely low counts and high random fraction associated with (90)Y -PET may significantly impair both qualitative and quantitative results. The aim of this work was to study image quality and noise level in relation to the quantification and bias performance of two types of Siemens PET scanners when imaging (90)Y and to compare experimental results with clinical data from two types of commercially available (90)Y microspheres...
July 2015: Medical Physics
https://www.readbyqxmd.com/read/26129385/we-g-bra-09-microsphere-brachytherapy-failure-mode-and-effects-analysis-in-a-dual-vendor-environment
#6
K C Younge, C I Lee, M Feng, P Novelli, J M Moran, J I Prisciandaro
PURPOSE: To improve the safety and quality of a dual-vendor microsphere brachytherapy program with failure mode and effects analysis (FMEA). METHODS: A multidisciplinary team including physicists, dosimetrists, a radiation oncologist, an interventional radiologist, and radiation safety personnel performed an FMEA for our dual-vendor microsphere brachytherapy program employing SIR-Spheres (Sirtex Medical Limited, Australia) and Theraspheres (BTG, England). We developed a program process tree and step-by-step instructions which were used to generate a comprehensive list of failure modes...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128591/mo-ab-201-03-the-alphabet-soup-of-regulatory-compliance-being-prepared-for-inspections
#7
L Kroger
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128589/mo-ab-201-01-regulatory-compliance-and-safety-with-new-radiotherapies-spheres-and-ra-223
#8
L Phillips
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128588/mo-ab-201-02-the-rso-and-the-rsc-challenges-and-opportunities
#9
C Dimock
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128587/mo-ab-201-00-radiation-safety-officer-update
#10
(no author information available yet)
UNLABELLED: The role of the Radiation Safety Officer at a medical facility can be complicated. The complexity of the position is based on the breadth of services provided at the institution and the nature of the radioactive materials license. Medical practices are constantly changing and the use of ionizing radiation continues to rise in this area. Some of the newer medical applications involving radiation have unique regulatory and safety issues that must be addressed. Oversight of the uses of radiation start at the local level (radiation safety officer, radiation safety committee) and are heavily impacted by outside agencies (i...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26112387/radioembolization-of-hepatocarcinoma-with-90-y-glass-microspheres-development-of-an-individualized-treatment-planning-strategy-based-on-dosimetry-and-radiobiology
#11
C Chiesa, M Mira, M Maccauro, C Spreafico, R Romito, C Morosi, T Camerini, M Carrara, S Pellizzari, A Negri, G Aliberti, C Sposito, S Bhoori, A Facciorusso, E Civelli, R Lanocita, B Padovano, M Migliorisi, M C De Nile, E Seregni, A Marchianò, F Crippa, V Mazzaferro
PURPOSE: The aim of this study was to optimize the dosimetric approach and to review the absorbed doses delivered, taking into account radiobiology, in order to identify the optimal methodology for an individualized treatment planning strategy based on (99m)Tc-macroaggregated albumin (MAA) single photon emission computed tomography (SPECT) images. METHODS: We performed retrospective dosimetry of the standard TheraSphere® treatment on 52 intermediate (n = 17) and advanced (i...
October 2015: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/25937772/transcatheter-embolization-therapy-in-liver-cancer-an-update-of-clinical-evidences
#12
REVIEW
Yì-Xiáng J Wáng, Thierry De Baere, Jean-Marc Idée, Sébastien Ballet
Transarterial chemoembolization (TACE) is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization. Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma (HCC) patients who cannot receive potentially curative therapies such as transplantation, resection or percutaneous ablation. TACE for liver cancer has been proven to be useful in local tumor control, to prevent tumor progression, prolong patients' life and control patient symptoms...
April 2015: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/25769582/radioembolization-using-yttrium-90-microspheres-as-bridging-and-downstaging-treatment-for-unresectable-hepatocellular-carcinoma-before-liver-transplantation-initial-single-center-experience
#13
M R Abdelfattah, M Al-Sebayel, D Broering, H Alsuhaibani
INTRODUCTION: HCC is the sixth most common malignancy worldwide and is the third most common cause of cancer related mortality. Moreover, the incidence of HCC is increasing. Surgical treatments for HCC including resection and/or transplantation provide the best curative outcomes in early stages. Unfortunately, many patients present at an advanced stage. Currently, locoregional therapies have an emerging role in the management of HCC for bridging to liver transplantation and for downstaging the disease to within transplant criteria...
March 2015: Transplantation Proceedings
https://www.readbyqxmd.com/read/25761642/status-of-colorectal-cancer-devices-present-scenario
#14
REVIEW
Shammy Chandel, Reyhan Akhtar, Pooja Sarotra, Bikash Medhi
PURPOSE: The purpose of this study was the colonoscopic detection and removal of neoplasia from the colorectum to prevent the development of colorectal cancer. METHOD: Various online medical databases were searched such as PubMed, ACS, NCI, NIH, WHO, etc. for relevant publications and clinical trials for new developments in colonoscopic devices that are intended for diagnostic visualization and therapeutic interventions of the digestive tract. RESULT: HD colon and I-Scan both has shown to increase the detection of sporadic adenomas with high quality...
June 2015: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/25678490/personalized-dosimetry-with-intensification-using-90y-loaded-glass-microsphere-radioembolization-induces-prolonged-overall-survival-in-hepatocellular-carcinoma-patients-with-portal-vein-thrombosis
#15
Etienne Garin, Yan Rolland, Julien Edeline, Nicolas Icard, Laurence Lenoir, Sophie Laffont, Habiba Mesbah, Mathias Breton, Laurent Sulpice, Karim Boudjema, Tanguy Rohou, Jean-Luc Raoul, Bruno Clement, Eveline Boucher
UNLABELLED: The objective of this study was to evaluate the response rate and survival of hepatocellular carcinoma portal vein thrombosis (PVT) patients treated with (90)Y-loaded glass microspheres using a personalized dosimetry and intensification concept. METHODS: The microspheres were administered to 41 hepatocellular carcinoma PVT patients (main = 12; lobar/segmental = 29). (99m)Tc-macroaggregated albumin SPECT/CT quantitative analysis was used to calculate the tumor dose (TD), healthy injected liver dose (HILD), and injected liver dose (ILD)...
March 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/25563137/evaluation-of-factors-affecting-tumor-response-and-survival-in-patients-with-primary-and-metastatic-liver-cancer-treated-with-microspheres
#16
Serkan Demirelli, Metin Erkilic, Ali Ozan Oner, Evrim Surer Budak, Seyda Gunduz, Ozhan Ozgur, Hakan Bozcuk, Hakki Timur Sindel, Adil Boz
OBJECTIVE: Radioembolization with the yttrium-90 (Y-90) microspheres is being used increasingly more often in the treatment of patients with primary or metastatic liver cancer. Although technetium-99m macroaggregated albumin (Tc-99m MAA) scintigraphy performed following diagnostic angiography has an important role in predicting the effectiveness of treatment and in dose estimation, the number of studies using quantitative assessment of Tc-99m MAA scintigraphy is limited in this field...
April 2015: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/25353006/determination-of-radiation-absorbed-dose-to-primary-liver-tumors-and-normal-liver-tissue-using-post-radioembolization-90-y-pet
#17
Shyam M Srinivas, Navin Natarajan, Joshua Kuroiwa, Sean Gallagher, Elie Nasr, Shetal N Shah, Frank P DiFilippo, Nancy Obuchowski, Bana Bazerbashi, Naichang Yu, Gordon McLennan
BACKGROUND: Radioembolization with Yttrium-90 ((90) Y) microspheres is becoming a more widely used transcatheter treatment for unresectable hepatocellular carcinoma (HCC). Using post-treatment (90) Y positron emission tomography/computerized tomography (PET/CT) scans, the distribution of microspheres within the liver can be determined and quantitatively assessed. We studied the radiation dose of (90) Y delivered to liver and treated tumors. METHODS: This retrospective study of 56 patients with HCC, including analysis of 98 liver tumors, measured and correlated the dose of radiation delivered to liver tumors and normal liver tissue using glass microspheres (TheraSpheres(®)) to the frequency of complications with modified response evaluation criteria in solid tumors (mRECIST)...
2014: Frontiers in Oncology
https://www.readbyqxmd.com/read/25272027/90sr-content-in-90y-labeled-sir-spheres-and-zevalin
#18
John Metyko, William Erwin, John Poston, Sandra Jimenez
Three different 90Y internally administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures atMD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize 90Y-labeled microspheres, while Zevalin is an 90Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from 90Y production methods. The 90Y in SIR-Spheres and Zevalin are produced from a 90Sr/90Y generator, which leaves measurable quantities of 90Sr in the final product...
November 2014: Health Physics
https://www.readbyqxmd.com/read/23927299/3d-inpatient-dose-reconstruction-from-the-pet-ct-imaging-of-90y-microspheres-for-metastatic-cancer-to-the-liver-feasibility-study
#19
E Fourkal, I Veltchev, M Lin, S Koren, J Meyer, M Doss, J Q Yu
PURPOSE: The introduction of radioembolization with microspheres represents a significant step forward in the treatment of patients with metastatic disease to the liver. This technique uses semiempirical formulae based on body surface area or liver and target volumes to calculate the required total activity for a given patient. However, this treatment modality lacks extremely important information, which is the three-dimensional (3D) dose delivered by microspheres to different organs after their administration...
August 2013: Medical Physics
https://www.readbyqxmd.com/read/23613103/boosted-selective-internal-radiation-therapy-with-90y-loaded-glass-microspheres-b-sirt-for-hepatocellular-carcinoma-patients-a-new-personalized-promising-concept
#20
E Garin, L Lenoir, J Edeline, S Laffont, H Mesbah, P Porée, L Sulpice, K Boudjema, M Mesbah, A Guillygomarc'h, E Quehen, M Pracht, J L Raoul, B Clement, Y Rolland, E Boucher
PURPOSE: To evaluate the impact of dosimetry based on MAA SPECT/CT for the prediction of response, toxicity and survival, and for treatment planning in patients with hepatocellular carcinoma (HCC) treated with (90)Y-loaded glass microspheres (TheraSphere®). METHODS: TheraSphere® was administered to 71 patients with inoperable HCC. MAA SPECT/CT quantitative analysis was used for the calculation of the tumour dose (TD), healthy injected liver dose (HILD), and total injected liver dose...
July 2013: European Journal of Nuclear Medicine and Molecular Imaging
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