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https://www.readbyqxmd.com/read/29331278/impact-of-treatment-with-a-protein-tyrosine-kinase-inhibitor-genistein-on-acute-and-chronic-experimental-schistosoma-mansoni-infection
#1
Maysa Mohamed Kamel Sobhy, Soheir Sayed Mahmoud, Shaimaa Helmy El-Sayed, Enas Mohamed Ali Rizk, Amira Raafat, Mohamed Sherif Ismail Negm
Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease...
January 10, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29329619/hepatic-fibropoiesis-in-dogs-naturally-infected-with-leishmania-leishmania-infantum-treated-with-liposome-encapsulated-meglumine-antimoniate-and-allopurinol
#2
R S Castro, I F G de Amorim, R A Pereira, S M Silva, L J Pinheiro, A J W Pinto, E G Azevedo, C Demicheli, M M V Caliari, D M Mosser, M S M Michalick, Frédéric J G Frezard, Wagner L Tafuri
Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol separately and in combination. Six treatment groups were defined: meglumine antimoniate encapsulated in nanometric liposomes (LMA), allopurinol (ALLOP); liposome-encapsulated meglumine antomoniate combined with allopurinol (LMA+ALLOP); empty liposomes (LEMP); empty liposomes combined with allopurinol (LEMP+ALLOP) and saline...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29328553/skin-colored-papules-on-the-elbows-with-a-granuloma-annulare-like-histological-pattern
#3
Julia Liersch, Christina Rohdenburg, Carla Duckheim, Jörg Schaller
No abstract text is available yet for this article.
January 12, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29326526/localized-gingival-overgrowths-a-report-of-six-cases
#4
Sohini Banerjee, T K Pal
Localized gingival overgrowths are commonly encountered in our day-to-day clinical practice and often present a diagnostic dilemma to the clinicians. These lesions vary depending on the location, site, extent, histology, and/or etiopathology. Although most of the localized gingival enlargements represent the reactive lesion to plaque accumulation, the differential diagnosis ranges from peripheral fibroma to pyogenic granuloma to peripheral fibroma with ossification and/or calcification, peripheral giant cell granuloma, etc...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29324063/granulomatous-lung-inflammation-is-nanoparticle-type-dependent
#5
Yves Pacheco, Marine Ponchon, Serge Lebecque, Alain Calender, Jean François Bernaudin, Dominique Valeyre, Marc Iglarz, Daniel S Strasser, Rolf Studer, Diego Freti, Toufiq Renno, Abederrazzaq Bentaher
BACKGROUND: Nanoparticles are increasingly suspected as a strong etiologic factor of granuloma formation. AIM OF THE STUDY: The aim of our study was to compare lung inflammatory response and histology changes following exposure of mice to two widely used nanoparticles: carbon nanotubes (MWCNT) and cadmium-based nanoparticles (QDOT705) in an attempt to better our understanding of granulomatous inflammation. MATERIALS AND METHODS: Various groups of mice were included: control mice and mice that were intranasally instilled with QDOT or MWCNT...
January 11, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29323072/orofacial-granulomatosis-a-disease-or-a-concealed-warning
#6
Priya Anil Bhagde, Jyoti D Bhavthankar, Mandakini Mandale
Granulomatosis is any condition characterized by the formation of multiple nodules or granulomas in the soft tissues. Differential diagnosis for orofacial region includes a wide spectrum of diseases, but most of these lesions present histopathologically as noncaseating granulomas, giving a nonspecific depiction and leading to a diagnostic impasse. In the absence of any diagnosable entity, the disease is labelled as "orofacial granulomatosis". A nine-year-old girl child reported with recurrent gingival enlargement and persistent macrochelia which histopathologically presented as noncaseating granulomas...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322121/silicone-granuloma-associated-with-pectoral-muscle-involvement-after-ruptured-breast-implant-a-novel-case-report
#7
Türkan İkizceli, Gökçe Gülşen, İlker Akın
In this study, an unusual case of a patient who was previously operated on a ruptured breast implant following silicone granuloma associated with pectoral muscle involvement is reported. A 72-year-old woman had undergone breast augmentation surgery when she was 52-year-old and silicone implant rupture 10 years later. After 10 years of ruptured silicone implant, her mammography showed diffuse, multiple high-density nodules in the left breast. The pectoral muscle was significantly hypertrophic. The magnetic resonance imaging showed that the pectoral muscle was quite hypertrophic and had heterogeneous enhancement...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29322116/efficiency-of-imaging-modalities-in-male-breast-disease-can-ultrasound-give-additional-information-for-assessment-of-gynecomastia-evolution
#8
Özgür Sarıca, A Nedim Kahraman, Enis Öztürk, Memik Teke
Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia. Materials and Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29321844/foreign-body-reaction-with-granuloma-following-achilles-tendon-reconstruction-with-the-lars-ligament
#9
Joshua Henry, Alistar J Konarski, Leena Joseph, Anand Pillai
Ligament reconstruction with the LARS ligament has been a popular choice owing to its low-complication rates compared with previously commercially available grafts. The non-active nature of the implant also meant that there were no foreign body reactions that had been described with other synthetic grafts. We describe the first reported case of a granulomatous foreign body reaction in a LARS ligament Achilles tendon graft and a technique to reconstruct the tendon following its excision.
January 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29321436/necrotizing-sarcoid-granulomatosis-with-natural-resolution-after-a-surgical-lung-biopsy
#10
Takayuki Shibata, Koichiro Takahashi, Masaru Uchida, Fumio Yamasaki, Michihiro Kawashima, Naoko Sueoka-Aragane
Necrotizing sarcoid granulomatosis (NSG) is a rare disease that is diagnosed based on pathological findings. We herein report the case of a 27-year-old man who had multiple nodular shadows in bilateral lung fields on chest radiography and elevated levels of C-reactive protein (CRP). The pathological evaluation of a lung biopsy specimen showed the infiltration of lymphocytes, granulomas with necrosis and granulomatous angiitis. He was therefore diagnosed with NSG. He has been followed without treatment, as his fever and CRP levels decreased immediately after the surgical lung biopsy...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321417/peripheral-ulcerative-keratitis-associated-with-granulomatosis-with-polyangiitis-emerging-despite-cyclophosphamide-successfully-treated-with-rituximab
#11
Yuya Fujita, Shoichi Fukui, Yushiro Endo, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Ryotaro Ueki, Masafumi Uematsu, Kaori Ishida, Kuniko Abe, Atsushi Kawakami
A 67-year-old Japanese man was diagnosed with granulomatosis with polyangiitis based on the presence of right maxillary sinusitis, proteinase 3 antineutrophil cytoplasmic antibody positivity, and right scleritis. A conjunctival biopsy specimen showed neutrophil-predominant infiltration around the vessels without granuloma. Because there was a risk of blindness, pulsed methylprednisolone and intravenous cyclophosphamide pulse therapy (IVCY) was started. However, it was ineffective, and peripheral ulcerative keratitis newly emerged...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29320774/how-many-passes-are-needed-for-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-sarcoidosis-a-prospective-multicenter-study
#12
Masahide Oki, Hideo Saka, Masahiko Ando, Harunori Nakashima, Akira Shiraki, Yasushi Murakami, Yoshihito Kogure, Chiyoe Kitagawa, Tatsuo Kato
BACKGROUND: While endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used as an initial diagnostic procedure for pathological confirmation of sarcoidosis, it is unclear how many passes are required to obtain diagnostic materials. OBJECTIVES: The aim of this study was to determine the number of needle passes needed for the diagnosis of stage I/II sarcoidosis using EBUS-TBNA. METHODS: At three institutions, 109 patients with suspected stage I/II sarcoidosis were recruited and underwent 6 passes of EBUS-TBNA for the main target lesion...
January 10, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29319778/granulomatous-intersticial-nephritis-secondary-to-sarcoidosis
#13
Tamires Teixeira Piraciaba, Carlos Alberto Balda, Luiz Antônio Ribeiro de Moura, Carlos Alberto de Castro Pereira, Gianna Mastroianni Kirsztajn
INTRODUCTION: Granulomatous interstitial nephritis is a rare condition, in which renal involvement is uncommon. Its etiology is variable, and may be medicinal, infectious or inflammatory origin. CASE REPORT: This is a 65-year-old male patient with renal lesions of unknown etiology, associated with hypercalcaemia. During the investigation, cardiac insufficiency with diastolic dysfunction and interstitial lung involvement on chest tomography were evidenced. Renal function (glomerular filtration rate) has partially improved with clinical measures...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29319141/the-use-of-67ga-scintigraphy-in-patients-with-sarcoidosis
#14
Ewa Malinowska, Anna Doboszyńska, Anna Śliwińska, John R Buscombe, Grzegorz Kulesza, Beata Moczulska, Jarosław B Ćwikła
Sarcoidosis is a systemic disease of unknown aetiology characterised by the formation of noncaseating granulomas in various organs and tissues. The various imaging modalities that are useful in the investigation of lesions, staging and establishing indications for treatment include: conventional radiography, CT, MRI, and scintigraphy with 67Ga, 201Tl, 99mTc sestamibi, and somatostatin receptor scintigraphy (SRS) as well as 18F-FDG-PET/CT. This paper discusses the most commonly used of the scintigraphic technique, gallium (67Ga) citrate) and its role in the evaluation and monitoring of patients with sarcoidosis...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29318713/hybrid-feature-extraction-techniques-for-microscopic-hepatic-fibrosis-classification
#15
Dalia S Ashour, Dina M Abou Rayia, Mohamed Maher Ata, Amira S Ashour, Mustafa M Abd Elnaby
Chronic liver diseases' hallmark is the fibrosis that results in liver function failure in advanced stages. One of the serious parasitic diseases affecting the liver tissues is schistosomiasis. Immunologic reactions to Schistosoma eggs leads to accumulation of collagen in the hepatic parenchyma causing fibrosis. Thus, monitoring and reporting the staging of the histopathological information related to liver fibrosis are essential for accurate diagnosis and therapy of the chronic liver diseases. Automated assessment of the microscopic liver tissue images is an essential process...
January 10, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29318643/malignancy-associated-generalized-perforating-granuloma-annulare
#16
R Satta, G Biondi, G M Puggioni, M A Montesu, F Rongioletti
No abstract text is available yet for this article.
January 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29318136/pleural-tuberculosis-medical-thoracoscopy-greatly-increases-the-diagnostic-accuracy
#17
Angelo Gianni Casalini, Pier Anselmo Mori, Maria Majori, Miriam Anghinolfi, Enrico Maria Silini, Letizia Gnetti, Federica Motta, Sandra Larini, Sara Montecchini, Roberta Pisi, Adriana Calderaro
Our objective was to evaluate the efficacy of a standardised work-up in the diagnosis of pleural tuberculosis (TB) that included fibreoptic bronchoscopy and medical thoracoscopy. A consecutive series of 52 pleural TB patients observed during the period 2001-2015 was evaluated retrospectively. 20 females, mean (range) age 39.7 (18-74) years, and 32 males, mean (range) age 45.75 (21-83) years, were included (28 non-EU citizens (53.8%)). The diagnosis of TB infections was established by identification (using stains, culture or molecular tests) of Mycobacterium tuberculosis in the pleura, sputum and/or bronchial specimens, or by evidence of caseous granulomas on pleural biopsies...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#18
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317853/real-time-observation-of-pathophysiological-processes-during-murine-experimental-schistosoma-japonicum-infection-using-high-resolution-ultrasound-imaging
#19
Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta, Shiro Iwanaga
Background: Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic lesions, the time-course kinetics of disease progression remains to be fully elucidated. Methods: The real-time process of the pathophysiology of schistosomiasis japonica from the early to late clinical phase was non-invasively observed in a murine experimental infection model using high-resolution ultrasonography...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29314333/programmed-cell-death-1-blockade-induced-cutaneous-sarcoid-like-epithelioid-granulomas-in-advanced-melanoma-a-case-report
#20
T Ogawa, Y Ishitsuka, K Iwamoto, H Koguchi-Yoshioka, R Tanaka, R Watanabe, Y Fujisawa, M Fujimoto
Sarcoidosis is a chronic, systemic inflammatory disorder of unknown etiology that is characterized by the formation of noncaseating granuloma in affected organs, most commonly the lung.1 In pulmonary sarcoidosis patients, the T helper 1 (Th1) cytokine profile of CD4+ as well as CD8+ T cells was demonstrated in bronchoalveolar lavage fluid.2 However, there has been no detailed description of a lymphocyte profile in cutaneous sarcoid-like epithelioid granulomas. Here, we report a case of sarcoid-like epithelioid granulomas induced by nivolumab in a patient with advanced melanoma and we performed functional lymphocyte analysis of the granuloma lesions...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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