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https://www.readbyqxmd.com/read/29148536/characterization-of-foreign-materials-in-paraffin-embedded-pathological-specimens-using-in-situ-multi-elemental-imaging-with-laser-spectroscopy
#1
Benoit Busser, Samuel Moncayo, Florian Trichard, Vincent Bonneterre, Nicole Pinel, Frédéric Pelascini, Philippe Dugourd, Jean-Luc Coll, Michel D'Incan, Julie Charles, Vincent Motto-Ros, Lucie Sancey
Pathologists typically encounter many disparate exogenous materials in clinical specimens during their routine histopathological examinations, especially within the skin, lymph nodes, and lungs. These foreign substances may be free extracellular deposits or induce several clinical abnormalities or histopathological patterns. However, pathologists almost never investigate or report the chemical nature of exogenous metals in clinical specimens due to a lack of convenient and available technologies. In this paper, a novel strategy based on laser-induced breakdown spectroscopy (LIBS) technology is evaluated for in situ multi-elemental tissue imaging...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29148196/umbilicus-and-its-extensive-clinical-repertoire
#2
Spencer W Beasley
The umbilicus is involved in a wide range of abnormalities in infants and children. The most severe are evident at birth and include exomphalos (omphalocele) and gastroschisis, both of which can be life-threatening but are easy to diagnose. Exomphalos is often associated with other congenital abnormalities, whereas the associated problems in gastroschisis are largely confined to the gut. Infection of the umbilicus in the neonate presents as omphalitis. The causes of a moist umbilicus following separation of the umbilical stump are multiple, from the relatively minor umbilical granuloma or ectopic bowel mucosa to the more significant patent urachus that leaks urine...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29147077/application-of-breast-ultrasound-elastography-to-differentiate-intracapsular-collection-from-silicone-induced-granuloma-of-breast-implant-capsule-complementarily-to-contrast-enhanced-breast-magnetic-resonance-imaging
#3
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Decio Roveda, Vilmar Marques de Oliveira
Background: To determine whether there is correlation between magnetic resonance imaging (MRI) findings and breast elastography to differentiate seroma/hematoma from silicone-induced granuloma of breast implant capsule (SIGBIC). Methods: Prospective study of 99 patients with breast implants submitted to breast MRI during the period from February 1 to May 1, 2017. Patients who present MRI findings of seroma/hematoma or SIGBIC were submitted to a complementary ultrasound elastography study to evaluate the correlation of the results...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29146061/sarcoid-like-granulomas-in-renal-cell-carcinoma-the-houston-methodist-hospital-experience
#4
Komal Arora, Mukul K Divatia, Luan Truong, Steven S Shen, Alberto G Ayala, Jae Y Ro
Sarcoid-like (SL) granulomas have been previously described in association with malignant tumors. These granulomas appear to be tumor-related but are not indicative of systemic sarcoidosis, and hence are referred to as SL reactions. These SL reactions can be seen within the primary tumor, its vicinity, or in uninvolved sites such as the spleen, bone marrow, skin, and/or regional lymph nodes draining the tumor. It is a widely held view that SL granulomas are caused by soluble antigenic factors, shed by tumor cells or released due to tumor necrosis...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29145499/clinical-tool-for-disease-phenotyping-in-granulomatous-lung-disease
#5
Lori J Silveira, Matthew Strand, Michael V Van Dyke, Margaret M Mroz, Anna V Faino, Dana M Dabelea, Lisa A Maier, Tasha E Fingerlin
BACKGROUND: Exposure to beryllium may lead to granuloma formation and fibrosis in those who develop chronic beryllium disease (CBD). Although disease presentation varies from mild to severe, little is known about CBD phenotypes. This study characterized CBD disease phenotypes using longitudinal measures of lung function. METHODS: Using a case-only study of 207 CBD subjects, subject-specific trajectories over time were estimated from longitudinal pulmonary function and exercise-tolerance tests...
2017: PloS One
https://www.readbyqxmd.com/read/29144832/postoperative-complications-of-dermis-fat-autografts-in-the-anophthalmic-socket
#6
Victoria Starks, Suzanne K Freitag
Reconstruction of the anophthalmic socket allows the use of an ocular prosthesis and rehabilitation of facial appearance. Dermis-fat grafting is one option in volume augmentation of the anophthalmic socket and presents unique benefits, including increased surface area within the socket and the ability to grow with pediatric patients. Postoperative complications of this procedure are relatively common. Minor complications, such as graft hirsutism, keratinization, and conjunctival cysts or granulomas, are managed easily by observation or simple intervention...
November 16, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29144803/endocrine-manifestations-of-primary-hyperoxaluria
#7
Shatha Murad, Yuval Eisenberg
OBJECTIVE: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction. It is associated with urolithiasis and nephrocalcinosis which progress to ESRD and systemic oxalosis. As oxalate deposits in tissues, non-parathyroid hormone (nonPTH) mediated hypercalcemia, oxalate osteopathy, primary hypothyroidism and primary hypogonadism develop. In this review, we will present a case of PH1 and provide an overview of this clinical entity and its endocrine manifestations...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142355/severe-hypercalcemia-related-to-silicone-granulomas-as-discovered-by-fdg-pet
#8
Dana E Amiraian, Joseph M Accurso, Manoj K Jain
Silicone injected for cosmetic purposes can provoke an inflammatory granulomatous response. In turn, silicone granulomas can lead to hypercalcemia, which is a rare, though potentially life-threatening condition. Hypercalcemia is a nonspecific laboratory finding with many potential etiologies. It may be difficult for clinicians to diagnose silicone-induced hypercalcemia, since the history of cosmetic silicone injections may not be elicited from the patient. Positron emission tomography using F-18-fluorodeoxyglucose (FDG-PET) can be used to evaluate patients with unexplained hypercalcemia as a means of searching for an occult malignancy or granulomatous process...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141567/discovery-of-thiazole-based-bis-heterocyclic-system-for-anti-inflammatory-potential
#9
Amit S Tapkir, Sohan S Chitlange, Ritesh P Bhole
BACKGROUND: We have developed a new series of 36 substituted thiazole derivatives prepared via reaction of substituted benzothiazole-2-amine with substituted phenacyl bromide Objective: This study was aimed to develop and successfully evaluate anti-inflammatory activity of substituted thiazole derivatives. METHOD: A new series of 36 substituted thiazole derivatives was synthesized and derivatives were characterized by analytical and spectrometric methods like IR, MS, and 1H NMR...
November 14, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29140806/florid-granuloma-annulare-like-reaction-in-regional-lymph-nodes-after-regression-of-red-pigment-in-tattoos
#10
Michael D Carter, Jonathan Trites, Shelly A McNeil, Noreen N M Walsh, Martin J Bullock
A healthy 50-year-old woman had a tattoo performed on the posterior aspect of her neck and another on the dorsum of her left foot. Several weeks later, she noted redness, tenderness, and intense pruritis at both tattoo sites. Treatment with cephalexin and hydrocortisone cream was instituted, without success. Within a few months, the red, but not black, pigment had disappeared from both tattoos and was replaced by pale areas of scarring. Persistently enlarged left supraclavicular and suboccipital lymph nodes were excised 7 and 10 months after receipt of the tattoos, respectively...
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29140132/mediation-of-the-single-walled-carbon-nanotubes-induced-pulmonary-fibrogenic-response-by-osteopontin-and-tgf-%C3%AE-1
#11
Timur O Khaliullin, Elena R Kisin, Ashley R Murray, Naveena Yanamala, Michael R Shurin, Dmitriy W Gutkin, Liliya M Fatkhutdinova, Valerian E Kagan, Anna A Shvedova
PURPOSE OF THE STUDY: A number of in vivo studies have shown that pulmonary exposure to carbon nanotubes (CNTs) may lead to an acute local inflammatory response, pulmonary fibrosis, and granulomatous lesions. Among the factors that play direct roles in initiation and progression of fibrotic processes are epithelial-mesenchymal transition and myofibroblasts recruitment/differentiation, both mediated by transforming growth factor-β1 (TGF-β1). Yet, other contributors to TGF-β1 associated signaling, such as osteopontin (OPN) has not been fully investigated...
October 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29139157/seronegative-granulomatosis-with-polyangiitis-presenting-with-multiple-cranial-nerve-palsies
#12
Eunhye Lee, Jynkyun Park, Seung Hong Choi, Sung-Hye Park
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), is a rare systemic disease characterized by necrotizing granulomas and vasculitis that usually presents in the respiratory tract and renal system. Here, we report a case of anti-neutrophil cytoplasmic antibody (ANCA)-negative GPA with diagnostic difficulties. Neurologic involvement in GPA is not uncommon, with up to 50% of patients manifesting with neurologic defects; however, it is usually a late event. This patient was a 50-year-old man whose first manifestation was multiple neurologic defects without respiratory or renal symptoms...
November 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29138686/insights-into-the-pathogenesis-and-clinicopathological-spectrum-of-oral-vegetable-granuloma-case-series-with-literature-review
#13
Shankargouda Patil, Roopa S Rao, A Thirumal Raj, Pavithra Venkataswamy, Vanishree Haragannavar, Shwetha Nambiar, Dominic Augustine, Sowmya Samudrala Venkatesiah, Sachin Sarode, Gargi Sarode
No abstract text is available yet for this article.
September 15, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/29136050/granulomatous-pigmented-purpuric-dermatosis
#14
Adam Allan, David A Altman, Wei Su
Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histologic variant of pigmented purpuric dermatosis (PPD). It includes classic histology changes of PPD with superimposed granulomas. This variant is thought to be associated with hyperlipidemia and is found predominantly in individuals in the Far East; however, a review of the literature that included 26 documented cases of GPPD revealed these associations might be becoming less clear. We report a case of GPPD in an elderly white man who had an eruption involving the majority of the lower legs...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29134676/a-safety-and-immunogenicity-study-of-a-novel-subunit-plague-vaccine-in-cynomolgus-macaques
#15
Li Liu, Dong Wei, Zhe Qu, Li Sun, Yufa Miao, Yanwei Yang, Jinbiao Lu, Weixin Du, Bingxiang Wang, Bo Li
Plague has led to millions of deaths in history and outbreaks continue to the present day. The efficacy limitations and safety concerns of the existing killed whole cell and live-attenuated vaccines call for the development of new vaccines. In this study, we evaluated the immunogenicity and safety of a novel subunit plague vaccine, comprising native F1 antigen and recombinant V antigen. The cynomolgus macaques in low- and high-dose vaccine groups were vaccinated at weeks 0, 2, 4 and 6, at dose levels of 15 μg F1 + 15 μg rV and 30 μg F1 + 30 μg rV respectively...
November 14, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29133635/is-the-distance-from-punctum-a-factor-in-the-anatomical-and-functional-success-of-canalicular-laceration-repairs
#16
Manpreet Singh, Natasha Gautam, Nitasha Ahir, Manpreet Kaur
PURPOSE: The aim is to analyze the influence of the location of lacrimal canalicular laceration over the eventual anatomical and functional success after surgery. METHODS: Retrospective, observational study of proximal canalicular laceration (PCL) and distal canalicular laceration (DCL) repairs by a single surgeon (MS). The distance between lacrimal punctum and the lateral canalicular lacerated end was defined as proximal (<6 mm) and distal (≥6 mm). The operation theater setup, microscopic magnified view, local adrenaline, and pigtail probe were used to locate the medial canalicular lacerated end...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29130033/danger-of-frustrated-sensors-role-of-toll-like-receptors-and-nod-like-receptors-in-aseptic-and-septic-inflammations-around-total-hip-replacements
#17
Michiaki Takagi, Yuya Takakubo, Jukka Pajarinen, Yasushi Naganuma, Hiroharu Oki, Masahiro Maruyama, Stuart B Goodman
The innate immune sensors, Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), can recognize not only exogenous pathogen-associated molecular patterns (PAMPs), but also endogenous molecules created upon tissue injury, sterile inflammation, and degeneration. Endogenous ligands are called damage-associated molecular patterns (DAMPs), and include endogenous molecules released from activated and necrotic cells as well as damaged extracellular matrix. TLRs and NLRs can interact with various ligands derived from PAMPs and DAMPs, leading to activation and/or modulation of intracellular signalling pathways...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29129226/measuring-bovine-%C3%AE-%C3%AE-t-cell-function-at-the-site-of-mycobacterium-bovis-infection
#18
Rachel A Rusk, Mitchell V Palmer, W Ray Waters, Jodi L McGill
Bovine γδ T cells are amongst the first cells to accumulate at the site of Mycobacterium bovis infection; however, their role in the developing lesion remains unclear. We utilized transcriptomics analysis, in situ hybridization, and a macrophage/γδ T cell co-culture system to elucidate the role of γδ T cells in local immunity to M. bovis infection. Transcriptomics analysis revealed that γδ T cells upregulated expression of several novel, immune-associated genes in response to stimulation with M. bovis antigen...
December 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29127573/eosinophilic-granulomatosis-with-polyangiitis-complicated-by-subarachnoid-hemorrhage-and-coronary-vasculitis-a-case-report-and-review-of-the-literature
#19
REVIEW
Shogo Matsuda, Shuzo Yoshida, Youhei Fujiki, Hidetoshi Satomi, Tohru Takeuchi, Yoshinobu Hirose, Shigeki Makino, Shigeki Arawaka
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by necrotizing vasculitis of small-sized vessels with extravascular granulomas and eosinophilic infiltration. The case of a 48-year-old Japanese woman with EGPA, who presented concurrently with subarachnoid hemorrhage (SAH) and coronary vasculitis, is reported. She initially presented with bronchial asthma, and then 8 months later she developed various symptoms caused by systemic eosinophilic vasculitis and was admitted to our hospital. Three days after admission, she started oral corticosteroid therapy, and her 2009 Five-Factor Score (FFS) was 0...
November 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29126438/therapeutic-effects-of-bone-marrow-derived-mononuclear-cells-from-healthy-or-silicotic-donors-on-recipient-silicosis-mice
#20
Helena D'Anunciação de Oliveira, Elga Bernardo Bandeira de Melo, Johnatas Dutra Silva, Jamil Zola Kitoko, Bianca Gutfilen, Thiago Barboza, Sergio Augusto Lopes de Souza, Christina Maeda Takiya, Patricia Rieken Macedo Rocco, Miquéias Lopes-Pacheco, Marcelo Marcos Morales
BACKGROUND: Administration of bone marrow mononuclear cells (BMMCs) modulates lung inflammation and fibrosis in experimental silicosis. However, no studies have evaluated whether silicosis affects the efficacy of autologous BMMCs treatment. We hypothesized that BMMCs obtained from healthy or silicotic mice may improve lung function, but they might affect the inflammatory and fibrotic processes differently in experimental silicosis. METHODS: C57BL/6 mice were randomly divided into control (C) and silicosis (SIL) groups...
November 10, 2017: Stem Cell Research & Therapy
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