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https://www.readbyqxmd.com/read/28240572/fluoroquinolones-for-the-treatment-and-prevention-of-multidrug-resistant-tuberculosis
#1
T R Sterling
Although fluoroquinolones (FQs) play an important role in the treatment of multidrug-resistant tuberculosis (MDR-TB), there are several issues that need to be addressed to optimize their effectiveness and minimize toxicity. This includes identification of the optimal dose of FQs such as levofloxacin (LVX) and moxifloxacin, and the optimal role of FQs in combination with other anti-tuberculosis drugs, particularly those with overlapping toxicity, such as QT prolongation. While the ability of FQs to penetrate into cavities and granulomas is likely beneficial, suboptimal sensitivity of genotypic tests to detect FQ resistance could negatively affect treatment outcomes of FQ-containing regimens...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28239844/spectrum-and-clinical-variants-of-giant-cell-elastolytic-granuloma
#2
Wan-Ting Chen, Pa-Fan Hsiao, Yu-Hung Wu
BACKGROUND: Giant cell elastolytic granuloma, also known as annular elastolytic giant cell granuloma or actinic granuloma, is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas. OBJECTIVES: To clarify clinical characteristics based on case series observation. METHODS: We retrospectively reviewed patients who fulfilled the pathological diagnosis criteria for giant cell elastolytic granuloma seen at Mackay Memorial Hospital from 2000 to 2014...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28237146/is-routine-histopathological-examination-of-dacryocystorhinostomy-dacryocystectomy-specimens-necessary-a-tertiary-eye-hospital-experience
#3
Hind Alkatan, Majed Al-Qurashi
PURPOSE: Limited literature documenting the incidence of unsuspected malignant neoplasm among dacryocystorhinostomy/Dacryocystectomy (DCR/DCT) specimens is reviewed to determine if routine biopsy of all the patients undergoing such procedures is required. We are evaluating if sending lacrimal sac specimens for histopathological examination is necessary as a routine patient's care standard. STUDY DESIGN: This is a retrospective study of all lacrimal sac specimens received for histopathological examination in a tertiary eye hospital over a period of 12 years...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28235614/anti-inflammatory-activity-of-the-essential-oil-obtained-from-ocimum-basilicum-complexed-with-%C3%AE-cyclodextrin-%C3%AE-cd-in-mice
#4
Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Francisco Rafael Alves Santana Cesário, Fyama Ferreira E Castro, Thaís Rodrigues de Albuquerque, Maria Neyze Martins Fernandes, Bruno Anderson Fernandes da Silva, Lucindo José Quintans Júnior, Adriano Antunes de Sousa Araújo, Paula Dos Passos Menezes, Paula Santos Nunes, Isabella Gonçalves Matos, Henrique Douglas Melo Coutinho, Almir Goncalves Wanderley, Irwin Rose Alencar de Menezes
Cyclodextrins (CDs) are cyclic oligosaccharides can enhance the bioavailability of drugs. Ocimum basilicum is an aromatic plant found in Brazil used in culinary. The essential oil of this plant presents anti-edematogenic and anti-inflammatory activities in acute and chronic inflammation. The aim of this study was to investigate the anti-inflammatory effects of the essential oil obtained from O. basilicum complexed with β - cyclodextrin (OBEO/β-CD) in mice. The complexation with β-cyclodextrin (β-CD) was performed by different methods and analyzed by differential scanning calorimetry (DSC), thermogravimetry (TG) and scanning electron microscopy (SEM)...
February 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28231240/galectin-3-histone-deacetylases-and-hedgehog-signaling-possible-convergent-targets-in-schistosomiasis-induced-liver-fibrosis
#5
REVIEW
Felipe Leite de Oliveira, Katia Carneiro, José Marques Brito, Mariana Cabanel, Jonathas Xavier Pereira, Ligia de Almeida Paiva, Wingkin Syn, Neil C Henderson, Marcia Cury El-Cheikh
Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histone deacetylases (HDACs), and Hedgehog (Hh) signaling with macrophage activation during Th1/Th2 immune responses, fibrogranuloma reaction, and tissue repair during schistosomiasis. Gal-3 is highly expressed by liver macrophages (Kupffer cells) around Schistosoma eggs...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28229119/actinic-granuloma-presenting-as-tender-linear-plaques-on-the-lateral-fingers-in-a-patient-with-newly-diagnosed-esophageal-cancer
#6
Timothy C Michaelis, Jamie L Woodcock, Katherina Kobraei Basic
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28228088/aryl-heteroaryl-substituted-celecoxib-derivatives-as-cox-2-inhibitors-synthesis-anti-inflammatory-activity-and-molecular-docking-studies
#7
Golla Madhava, Katla Venkata Ramana, Saddala Madhu Sudhana, Devineni Subba Rao, Kuntrapakam Hema Kumar, Valluru Lokanatha, Asupatri Usha Rani, Chamarthi Naga Raju
BACKGROUND: Cyclooxygenase (COX-2) inhibitors have been developed to provide better anti-inflammatory and analgesic efficacy than those of traditional NSAIDs. Several compounds having selective COX-2 inhibitors such as SC-558, Celecoxib, Rofecoxib, Valdecoxib and Etoricoxib are marketed as new generation NSAIDs and block the production of prostaglandins (PGs) in inflammatory cells. New anti-inflammatory dynamic agents with improved potency and safety profile are still needed. OBJECTIVE: As a part of our continuation research work towards the synthesis of anti-inflammatory agents, the synthesis of N-substituted aryl/heteroaryl-pyrazole-1yl benzene sulfonamide (Celecoxib) derivatives, and evaluated their anti-inflammatory activity in both methods in vitro and in vivo, and molecular docking study on COX-2 enzyme will be discussed in this study...
February 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28225950/diabetes-mellitus-and-the-skin
#8
Adriana Lucia Mendes, Helio Amante Miot, Vidal Haddad
Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225101/macrophage-infiltration-of-electrospun-polyester-fibers
#9
Shen Liu, Hua Chen, Tianyi Wu, Guoqing Pan, Cunyi Fan, Yaozeng Xu, Wenguo Cui
Electrospun fibrous polylactide (PLA) membranes have been widely used for peritendinous anti-adhesion, but their degradation may lead to granuloma formation triggered by macrophages as the result of a foreign body reaction. To understand and solve this problem in peritendinous anti-adhesion, the effects of electrospun fibrous PLA membranes (PLA-M) and the mechanism by which macrophages elicit a foreign body reaction should be elaborated. Thus, the purpose of this study was to evaluate the ability of PLA-M and ibuprofen (IBU)-loaded fibrous PLA membranes (IBU/PLA-M) to prevent adhesion/granuloma formation around the tendon, and to understand the mechanism of macrophage infiltration...
February 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28224227/-exceptional-pacemaker-complication-in-still-s-disease
#10
Salma Haj Kheder, Thomas Hummel, Heike Majewski, Rafael Jimènez, Alexander Wutzler
CASE REPORT: A 49-year-old man with Still's disease presented with a rash above his pacemaker scar. In 2012, there was a replacement of the generator in which the position was changed from subpectoral to subcutaneous. A revision operation was performed after the local finding became worse, turning from a granuloma to a macula. THERAPY: During surgery, a superficial position of the leads was revealed. Both leads and generator were removed with great effort from the granulation tissue...
February 21, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28223750/tumor-necrosis-factor-alpha-blocker-induced-erythrodermic-sarcoidosis-in-with-juvenile-rheumatoid-arthritis-a-case-report-and-review-of-the-literature
#11
Su-Kyung Park, Pyung-Han Hwang, Seok-Kweon Yun, Han-Uk Kim, Jin Park
The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy and review previous studies of cutaneous sarcoidosis. A 6-year-old Korean girl who had been suffering from juvenile rheumatoid arthritis presented with generalized erythematous skin eruption involving more than about 90% of her body surface area...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223152/pathological-findings-and-prognosis-in-a-large-prospective-cohort-of-chronic-hypersensitivity-pneumonitis
#12
Ping Wang, Kirk D Jones, Anatoly Urisman, Brett M Elicker, Thomas Urbania, Kerri A Johannson, Deborah Assayag, Joyce Lee, Paul J Wolters, Harold R Collard, Laura L Koth
BACKGROUND: The ability of specific histopathological features to predict mortality or lung transplant in chronic hypersensitivity pneumonitis patients is unknown. METHODS: Patients with chronic hypersensitivity pneumonitis diagnosed by surgical lung biopsy were identified from an ongoing longitudinal cohort. The surgical lung biopsy slides were evaluated prospectively by an experienced thoracic pathologist using a standardized checklist to differentiate the major pathologic patterns and score the presence of specific histopathological features...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28221114/mycobacterium-tuberculosis-infection-in-free-roaming-wild-asian-elephant
#13
Basavegowdanadoddi Marinaik Chandranaik, Beechagondahalli Papanna Shivashankar, Kunigal Srinivasa Umashankar, Poojappa Nandini, Papanna Giridhar, Somenahalli Munivenkatappa Byregowda, Basavegowdanadoddi Marinaik Shrinivasa
Postmortem examination of a wild Asian elephant at Rajiv Gandhi National Park, India, revealed nodular lesions, granulomas with central caseation, and acid-fast bacilli in the lungs. PCR and nucleotide sequencing confirmed the presence of Mycobacterium tuberculosis. This study indicates that wild elephants can harbor M. tuberculosis that can become fatal.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28220943/sonographic-appearance-of-a-cholesterol-granuloma-mimicking-breast-cancer
#14
Young-Seon Kim, Jung Min Chang
A breast cholesterol granuloma is a rare benign condition that can be a pitfall in diagnosing breast cancer. We describe a cholesterol granuloma in the breast mimicking breast cancer on sonography. The mass was confirmed to be a cholesterol granuloma through a core needle biopsy, but an excisional biopsy was eventually performed due to suspicious sonographic appearance and histopathological examination of the specimen confirmed the diagnosis. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound, 2017.
February 21, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28219077/radiopathological-features-and-identification-of-mycobacterial-infections-in-granulomatous-nodules-resected-from-the-lung
#15
Yumi Sakakibara, Yoshimi Suzuki, Toshihide Fujie, Takumi Akashi, Tadatsune Iida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase
BACKGROUND: Pulmonary granulomas are sometimes resected because they resemble lung cancer and false-positive findings come through from positron emission tomography (PET) using 18fluorine-fluorodeoxyglucose (18F-FDG). Mycobacterial infection is a common cause of granulomas. OBJECTIVE: The purpose of this study was to evaluate the radiopathological features and the methods for identifying mycobacterial infections in granulomatous nodules resected from the lung. METHODS: Thirty-five solitary lesions resected because of suspected lung cancer were enrolled, including 22 nonfungal granulomatous lesions and 13 benign lesions as controls...
February 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28218266/crystal-nephropathies-mechanisms-of-crystal-induced-kidney-injury
#16
REVIEW
Shrikant R Mulay, Hans-Joachim Anders
Crystals can trigger a wide range of kidney injuries that can lead to acute kidney injury, chronic kidney disease, renal colic or nephrocalcinosis, depending on the localization and dynamics of crystal deposition. Studies of the biology of crystal handling by the kidney have shown that the formation of different crystals and other microparticles and the associated mechanisms of renal damage share molecular mechanisms, such as stimulation of the NLRP3 inflammasome or direct cytotoxicity through activation of the necroptosis signalling pathway...
February 20, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28217140/evaluation-of-polymerase-chain-reaction-in-space-occupying-lesions-of-liver-reported-as-granulomatous-inflammation-tuberculosis-on-fine-needle-aspiration-cytology
#17
Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
BACKGROUND: Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. OBJECTIVE: To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (TB) in cases reported as granulomatous inflammation/TB in liver lesions. MATERIALS AND METHODS: This was a retrospective study including a total of 17 cases of liver space-occupying lesions (SOLs) reported as granulomatous inflammation (n = 12) and TB (n = 5)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28216612/macrophages-mtorc1-drives-granulomas
#18
Lucy Bird
No abstract text is available yet for this article.
March 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28212670/characterization-of-schistosoma-japonicum-cp1412-protein-as-a-novel-member-of-the-ribonuclease-t2-molecule-family-with-immune-regulatory-function
#19
Xue-Dan Ke, Shuang Shen, Li-Jun Song, Chuan-Xin Yu, Mihoko Kikuchi, Kenji Hirayama, Hong Gao, Jie Wang, Xuren Yin, Yuan Yao, Qian Liu, Wei Zhou
BACKGROUND: Schistosome infection typically induces a polarized Th2 type host immune response. As egg antigen molecules play key roles in this immunoregulatory process, clarifying their functions in schistosomiasis would facilitate the development of vaccine and immunotherapeutic methods. Schistosoma japonicum (Sj) CP1412 (GenBank: AY57074.1) has been identified as a new member of the RNase T2 family with immune regulatory functions. METHODS: The expression plasmid Sj CP1412-pET28a was constructed and transformed into bacteria for production of recombinant Sj CP1412 protein (rSj CP1412) via IPTG induction...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28211877/fresh-frozen-amniotic-membrane-for-conjunctival-reconstruction-after-excision-of-neoplastic-and-presumed-neoplastic-conjunctival-lesions
#20
U Agraval, P Rundle, I G Rennie, S Salvi
PurposeSuspicious neoplastic conjunctival lesions often require wide excision with tumour-free margins, leaving significant conjunctival defects requiring reconstruction. In this study we report the results of using fresh frozen amniotic membrane grafts (AMG) after wide excision of potentially malignant lesions.MethodsRetrospective review of 53 patients; between January 2011 and April 2014. Conjunctival lesions were excised with a non-touch technique (2 mm margin) and sent for histopathological analysis. The surgical margins were treated with cryotherapy and a fresh frozen AMG was used to cover the defect...
February 17, 2017: Eye
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